ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein-cofactor linkage (GO:0018065)	7.57000645
2	neuron fate determination (GO:0048664)	6.60775701
3	cysteine metabolic process (GO:0006534)	6.52975718
4	homocysteine metabolic process (GO:0050667)	6.01290364
5	astrocyte differentiation (GO:0048708)	5.11444342
6	cardiac left ventricle morphogenesis (GO:0003214)	4.96401802
7	cell proliferation in forebrain (GO:0021846)	4.95212149
8	fucose catabolic process (GO:0019317)	4.65917359
9	L-fucose metabolic process (GO:0042354)	4.65917359
10	L-fucose catabolic process (GO:0042355)	4.65917359
11	serine family amino acid biosynthetic process (GO:0009070)	4.57281379
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.49776967
13	glutathione derivative metabolic process (GO:1901685)	4.18473286
14	glutathione derivative biosynthetic process (GO:1901687)	4.18473286
15	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.17833650
16	type B pancreatic cell development (GO:0003323)	4.13383613
17	histone mRNA catabolic process (GO:0071044)	4.10987569
18	estrogen biosynthetic process (GO:0006703)	4.06399693
19	basic amino acid transport (GO:0015802)	4.00262049
20	pituitary gland development (GO:0021983)	3.98170781
21	oxidative demethylation (GO:0070989)	3.96455812
22	proteasome assembly (GO:0043248)	3.95290988
23	intra-S DNA damage checkpoint (GO:0031573)	3.89642649
24	cranial nerve development (GO:0021545)	3.82779999
25	tongue development (GO:0043586)	3.79388784
26	otic vesicle formation (GO:0030916)	3.75373380
27	histone mRNA metabolic process (GO:0008334)	3.72165030
28	sulfur amino acid catabolic process (GO:0000098)	3.69499287
29	negative regulation of telomere maintenance (GO:0032205)	3.69138377
30	meiotic chromosome segregation (GO:0045132)	3.67805652
31	regulation of telomere maintenance via telomerase (GO:0032210)	3.65051044
32	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.62980672
33	chaperone-mediated protein transport (GO:0072321)	3.58554374
34	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.54172292
35	establishment of integrated proviral latency (GO:0075713)	3.47516717
36	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.45258535
37	ncRNA 3-end processing (GO:0043628)	3.40567455
38	prepulse inhibition (GO:0060134)	3.38948802
39	ribosomal large subunit biogenesis (GO:0042273)	3.31823984
40	behavioral response to ethanol (GO:0048149)	3.26449622
41	keratinocyte development (GO:0003334)	3.22992986
42	pattern specification involved in kidney development (GO:0061004)	3.21448953
43	telomere maintenance via telomerase (GO:0007004)	3.21313255
44	ATP synthesis coupled proton transport (GO:0015986)	3.20692407
45	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.20692407
46	radial glial cell differentiation (GO:0060019)	3.18101808
47	exogenous drug catabolic process (GO:0042738)	3.15538019
48	regulation of glutamate secretion (GO:0014048)	3.14131182
49	intestinal cholesterol absorption (GO:0030299)	3.12045634
50	ventricular system development (GO:0021591)	3.11025741
51	neuronal stem cell maintenance (GO:0097150)	3.06046200
52	female gonad development (GO:0008585)	3.03549483
53	prenylation (GO:0097354)	3.03322417
54	protein prenylation (GO:0018342)	3.03322417
55	epithelial cell fate commitment (GO:0072148)	3.02179729
56	RNA-dependent DNA replication (GO:0006278)	2.98479098
57	epithelial cilium movement (GO:0003351)	2.96692580
58	fucosylation (GO:0036065)	2.95878483
59	serine family amino acid metabolic process (GO:0009069)	2.95186605
60	presynaptic membrane assembly (GO:0097105)	2.94878622
61	isoprenoid biosynthetic process (GO:0008299)	2.94773599
62	spinal cord motor neuron differentiation (GO:0021522)	2.93591058
63	heart contraction (GO:0060047)	2.93339383
64	heart process (GO:0003015)	2.93339383
65	DNA double-strand break processing (GO:0000729)	2.92253236
66	hydrogen peroxide biosynthetic process (GO:0050665)	2.92116063
67	regulation of mitochondrial translation (GO:0070129)	2.89475866
68	glandular epithelial cell development (GO:0002068)	2.85198416
69	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.85030653
70	motile cilium assembly (GO:0044458)	2.83478022
71	negative regulation of astrocyte differentiation (GO:0048712)	2.78111928
72	neural tube formation (GO:0001841)	2.77369296
73	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.74307700
74	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.74307700
75	regulation of translation, ncRNA-mediated (GO:0045974)	2.74307700
76	cullin deneddylation (GO:0010388)	2.73869222
77	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.72354766
78	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.71318406
79	centriole replication (GO:0007099)	2.70266071
80	negative regulation of amino acid transport (GO:0051956)	2.70022660
81	negative regulation of epithelial to mesenchymal transition (GO:0010719)	2.69891398
82	fucose metabolic process (GO:0006004)	2.69148327
83	interferon-gamma secretion (GO:0072643)	2.68044383
84	omega-hydroxylase P450 pathway (GO:0097267)	2.67419114
85	positive regulation of vascular permeability (GO:0043117)	2.66635851
86	mRNA cleavage (GO:0006379)	2.65757571
87	reciprocal DNA recombination (GO:0035825)	2.65293181
88	reciprocal meiotic recombination (GO:0007131)	2.65293181
89	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.65284943
90	double-strand break repair via homologous recombination (GO:0000724)	2.65125631
91	water-soluble vitamin biosynthetic process (GO:0042364)	2.64991068
92	recombinational repair (GO:0000725)	2.61838387
93	artery smooth muscle contraction (GO:0014824)	2.61691628
94	labyrinthine layer development (GO:0060711)	2.61239874
95	protein K11-linked deubiquitination (GO:0035871)	2.60746685
96	response to pheromone (GO:0019236)	2.57296120
97	type B pancreatic cell proliferation (GO:0044342)	2.56719663
98	reactive oxygen species biosynthetic process (GO:1903409)	2.56280029
99	epoxygenase P450 pathway (GO:0019373)	2.55088391
100	regulation of timing of cell differentiation (GO:0048505)	2.54101039

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.19051504
2	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	4.07166835
3	AR_21572438_ChIP-Seq_LNCaP_Human	3.19809654
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.90744473
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.76911988
6	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.61520813
7	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.55288999
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.35732036
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26516091
10	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.16470842
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.15653223
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.10813037
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.10515309
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.01060848
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.93888415
16	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.88448942
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.86606509
18	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.85407323
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.84228855
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.81060722
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.78473462
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70597432
23	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.70443792
24	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.70051986
25	P300_19829295_ChIP-Seq_ESCs_Human	1.66258911
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.63893234
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.63861568
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.62860613
29	GBX2_23144817_ChIP-Seq_PC3_Human	1.59734791
30	VDR_22108803_ChIP-Seq_LS180_Human	1.58301317
31	AR_25329375_ChIP-Seq_VCAP_Human	1.57606507
32	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57178712
33	FUS_26573619_Chip-Seq_HEK293_Human	1.55576883
34	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.53772706
35	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.53772706
36	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.53772706
37	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.53362617
38	IGF1R_20145208_ChIP-Seq_DFB_Human	1.50966823
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45387476
40	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.41785357
41	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.40192899
42	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.38057895
43	TCF4_22108803_ChIP-Seq_LS180_Human	1.37873748
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35447167
45	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.34761532
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34295677
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.33629174
48	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32403801
49	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.31990655
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29943874
51	KDM2B_26808549_Chip-Seq_REH_Human	1.29029415
52	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.27580349
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27055437
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.27055437
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.26931420
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26203863
57	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.26002712
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.25637140
59	REST_21632747_ChIP-Seq_MESCs_Mouse	1.22980825
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22623538
61	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.22257514
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22128525
63	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21022603
64	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.19377244
65	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18519196
66	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17948086
67	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.17823334
68	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.16601911
69	AR_20517297_ChIP-Seq_VCAP_Human	1.16235800
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16141453
71	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.16040899
72	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.15759821
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15392037
74	PHF8_20622853_ChIP-Seq_HELA_Human	1.15037154
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14676018
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.14326733
77	EWS_26573619_Chip-Seq_HEK293_Human	1.12471630
78	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.11927505
79	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11292015
80	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11089751
81	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.10741508
82	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.10397480
83	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.09035558
84	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.08790728
85	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08299377
86	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.06799207
87	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05202494
88	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05068408
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02405082
90	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.01833993
91	ER_23166858_ChIP-Seq_MCF-7_Human	1.01074153
92	NCOR_22424771_ChIP-Seq_293T_Human	1.00486729
93	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.98864209
94	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.97478686
95	STAT3_18555785_ChIP-Seq_MESCs_Mouse	0.96359319
96	ELK1_19687146_ChIP-ChIP_HELA_Human	0.96339094
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95985813
98	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.94573964
99	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.94053184
100	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92189723

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	6.73957418
2	MP0003136_yellow_coat_color	5.32275422
3	MP0000566_synostosis	4.15957281
4	MP0010234_abnormal_vibrissa_follicle	3.01463537
5	MP0006292_abnormal_olfactory_placode	2.93879983
6	MP0003123_paternal_imprinting	2.84984831
7	MP0005408_hypopigmentation	2.69744993
8	MP0003011_delayed_dark_adaptation	2.62625191
9	MP0002638_abnormal_pupillary_reflex	2.51315870
10	MP0002938_white_spotting	2.31869265
11	MP0005647_abnormal_sex_gland	2.18225093
12	MP0005084_abnormal_gallbladder_morpholo	2.10965656
13	MP0008058_abnormal_DNA_repair	2.09361649
14	MP0002249_abnormal_larynx_morphology	2.09237338
15	MP0004185_abnormal_adipocyte_glucose	2.06225737
16	MP0005623_abnormal_meninges_morphology	2.00626782
17	MP0008875_abnormal_xenobiotic_pharmacok	1.97227872
18	MP0001764_abnormal_homeostasis	1.92731797
19	MP0001986_abnormal_taste_sensitivity	1.81519605
20	MP0008877_abnormal_DNA_methylation	1.79582135
21	MP0000631_abnormal_neuroendocrine_gland	1.78247113
22	MP0003718_maternal_effect	1.68131683
23	MP0000049_abnormal_middle_ear	1.67276960
24	MP0002796_impaired_skin_barrier	1.61232025
25	MP0002138_abnormal_hepatobiliary_system	1.58343294
26	MP0005377_hearing/vestibular/ear_phenot	1.54667784
27	MP0003878_abnormal_ear_physiology	1.54667784
28	MP0002254_reproductive_system_inflammat	1.54334986
29	MP0008872_abnormal_physiological_respon	1.48678385
30	MP0001485_abnormal_pinna_reflex	1.43815127
31	MP0004782_abnormal_surfactant_physiolog	1.42696522
32	MP0002396_abnormal_hematopoietic_system	1.42508724
33	MP0003890_abnormal_embryonic-extraembry	1.42179885
34	MP0001177_atelectasis	1.41782533
35	MP0003195_calcinosis	1.38971252
36	MP0004043_abnormal_pH_regulation	1.37376452
37	MP0010030_abnormal_orbit_morphology	1.34879440
38	MP0003787_abnormal_imprinting	1.33888317
39	MP0005646_abnormal_pituitary_gland	1.32696036
40	MP0002837_dystrophic_cardiac_calcinosis	1.32379870
41	MP0000778_abnormal_nervous_system	1.31836641
42	MP0000762_abnormal_tongue_morphology	1.29496147
43	MP0004147_increased_porphyrin_level	1.22695802
44	MP0005332_abnormal_amino_acid	1.22327742
45	MP0001666_abnormal_nutrient_absorption	1.19407866
46	MP0010094_abnormal_chromosome_stability	1.19348810
47	MP0000639_abnormal_adrenal_gland	1.14001784
48	MP0002277_abnormal_respiratory_mucosa	1.12479540
49	MP0000372_irregular_coat_pigmentation	1.11488209
50	MP0003186_abnormal_redox_activity	1.09363445
51	MP0003567_abnormal_fetal_cardiomyocyte	1.06996383
52	MP0003936_abnormal_reproductive_system	1.06330921
53	MP0002234_abnormal_pharynx_morphology	1.03857951
54	MP0005551_abnormal_eye_electrophysiolog	1.02803148
55	MP0001188_hyperpigmentation	1.02525647
56	MP0002928_abnormal_bile_duct	1.02273538
57	MP0005253_abnormal_eye_physiology	0.98642085
58	MP0002653_abnormal_ependyma_morphology	0.98222274
59	MP0000026_abnormal_inner_ear	0.97049886
60	MP0003121_genomic_imprinting	0.94313658
61	MP0005666_abnormal_adipose_tissue	0.93778204
62	MP0009053_abnormal_anal_canal	0.93723644
63	MP0002102_abnormal_ear_morphology	0.93271281
64	MP0006072_abnormal_retinal_apoptosis	0.91309408
65	MP0004215_abnormal_myocardial_fiber	0.91100109
66	MP0002067_abnormal_sensory_capabilities	0.88366904
67	MP0001293_anophthalmia	0.86900323
68	MP0005248_abnormal_Harderian_gland	0.85172329
69	MP0003122_maternal_imprinting	0.82698559
70	MP0003755_abnormal_palate_morphology	0.82521528
71	MP0003638_abnormal_response/metabolism_	0.80164392
72	MP0004142_abnormal_muscle_tone	0.78704628
73	MP0005501_abnormal_skin_physiology	0.78434755
74	MP0000955_abnormal_spinal_cord	0.78251889
75	MP0000467_abnormal_esophagus_morphology	0.76828216
76	MP0002932_abnormal_joint_morphology	0.76697036
77	MP0005319_abnormal_enzyme/_coenzyme	0.71822174
78	MP0000653_abnormal_sex_gland	0.70824890
79	MP0001186_pigmentation_phenotype	0.70816101
80	MP0005388_respiratory_system_phenotype	0.70159114
81	MP0002133_abnormal_respiratory_system	0.70159114
82	MP0005171_absent_coat_pigmentation	0.69423121
83	MP0002111_abnormal_tail_morphology	0.68471103
84	MP0003698_abnormal_male_reproductive	0.67111562
85	MP0002098_abnormal_vibrissa_morphology	0.65564201
86	MP0005197_abnormal_uvea_morphology	0.65525543
87	MP0003115_abnormal_respiratory_system	0.64470915
88	MP0009780_abnormal_chondrocyte_physiolo	0.63924601
89	MP0001486_abnormal_startle_reflex	0.63301040
90	MP0004742_abnormal_vestibular_system	0.62035267
91	MP0002210_abnormal_sex_determination	0.61772199
92	MP0008789_abnormal_olfactory_epithelium	0.61617383
93	MP0010678_abnormal_skin_adnexa	0.61415881
94	MP0001145_abnormal_male_reproductive	0.61315055
95	MP0002572_abnormal_emotion/affect_behav	0.61059377
96	MP0003937_abnormal_limbs/digits/tail_de	0.60631423
97	MP0000579_abnormal_nail_morphology	0.59241865
98	MP0009250_abnormal_appendicular_skeleto	0.58860459
99	MP0004885_abnormal_endolymph	0.57781627
100	MP0002557_abnormal_social/conspecific_i	0.57532675

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	5.22187895
2	Dyschromatopsia (HP:0007641)	5.19123588
3	Adrenal hypoplasia (HP:0000835)	4.67819478
4	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.13173481
5	Rib fusion (HP:0000902)	3.97480294
6	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.90076773
7	Abdominal situs inversus (HP:0003363)	3.79477896
8	Abnormality of abdominal situs (HP:0011620)	3.79477896
9	Aplastic anemia (HP:0001915)	3.69037249
10	Septo-optic dysplasia (HP:0100842)	3.68949638
11	Neuroendocrine neoplasm (HP:0100634)	3.64483412
12	Conjunctival hamartoma (HP:0100780)	3.61297745
13	Pheochromocytoma (HP:0002666)	3.50924705
14	Choroideremia (HP:0001139)	3.43690427
15	Central scotoma (HP:0000603)	3.35926125
16	Oral leukoplakia (HP:0002745)	3.19291246
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.18820021
18	Absent/shortened dynein arms (HP:0200106)	3.18820021
19	Thickened helices (HP:0000391)	3.16665582
20	Methylmalonic acidemia (HP:0002912)	3.09590465
21	Hypoplastic pelvis (HP:0008839)	3.04295243
22	Birth length less than 3rd percentile (HP:0003561)	2.94519909
23	True hermaphroditism (HP:0010459)	2.76908507
24	Chronic bronchitis (HP:0004469)	2.70406350
25	Hyperglycinemia (HP:0002154)	2.68683717
26	Vertebral hypoplasia (HP:0008417)	2.65126020
27	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	2.65126020
28	Abnormal ciliary motility (HP:0012262)	2.64722238
29	Optic nerve hypoplasia (HP:0000609)	2.59088067
30	Missing ribs (HP:0000921)	2.53254883
31	Hyperventilation (HP:0002883)	2.50441345
32	Pancreatic fibrosis (HP:0100732)	2.47896083
33	Abnormal respiratory motile cilium morphology (HP:0005938)	2.47402636
34	Abnormal respiratory epithelium morphology (HP:0012253)	2.47402636
35	Split foot (HP:0001839)	2.46376858
36	Constricted visual fields (HP:0001133)	2.44642461
37	Abnormality of the diencephalon (HP:0010662)	2.41425389
38	Hamartoma of the eye (HP:0010568)	2.40593750
39	Adenoma sebaceum (HP:0009720)	2.39836181
40	Angiofibromas (HP:0010615)	2.39836181
41	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.39205401
42	Palpitations (HP:0001962)	2.36406751
43	Hemivertebrae (HP:0002937)	2.35664380
44	Congenital malformation of the right heart (HP:0011723)	2.29385187
45	Double outlet right ventricle (HP:0001719)	2.29385187
46	Hypoproteinemia (HP:0003075)	2.28439646
47	Neoplasm of the peripheral nervous system (HP:0100007)	2.27997587
48	Esophageal atresia (HP:0002032)	2.22652084
49	Tinnitus (HP:0000360)	2.22216036
50	Abnormal respiratory motile cilium physiology (HP:0012261)	2.21676572
51	Patent foramen ovale (HP:0001655)	2.19046943
52	Sclerocornea (HP:0000647)	2.18361236
53	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.18306106
54	Prostate neoplasm (HP:0100787)	2.13264762
55	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.12949889
56	Absent epiphyses (HP:0010577)	2.12949889
57	Bone cyst (HP:0012062)	2.12326217
58	Arterial tortuosity (HP:0005116)	2.10585501
59	Hepatic necrosis (HP:0002605)	2.09687903
60	Irregular epiphyses (HP:0010582)	2.09475490
61	Progressive cerebellar ataxia (HP:0002073)	2.08232258
62	Neonatal respiratory distress (HP:0002643)	2.07416587
63	Furrowed tongue (HP:0000221)	2.07294484
64	High anterior hairline (HP:0009890)	2.06925236
65	Rhinitis (HP:0012384)	2.06498727
66	Gastrointestinal atresia (HP:0002589)	1.97304601
67	Abnormality of the carotid arteries (HP:0005344)	1.97298243
68	Tubular atrophy (HP:0000092)	1.96994341
69	Nasal polyposis (HP:0100582)	1.95532542
70	Exotropia (HP:0000577)	1.93616159
71	Stenosis of the external auditory canal (HP:0000402)	1.92657372
72	Abnormality of chromosome stability (HP:0003220)	1.92572329
73	Maternal diabetes (HP:0009800)	1.91452917
74	Methylmalonic aciduria (HP:0012120)	1.90184762
75	Triphalangeal thumb (HP:0001199)	1.88951636
76	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.88828962
77	Hepatocellular necrosis (HP:0001404)	1.86036141
78	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.85458091
79	Abnormality of midbrain morphology (HP:0002418)	1.85081838
80	Molar tooth sign on MRI (HP:0002419)	1.85081838
81	Genetic anticipation (HP:0003743)	1.82274908
82	Recurrent sinusitis (HP:0011108)	1.81896728
83	Type II lissencephaly (HP:0007260)	1.81363958
84	Abnormality of the fovea (HP:0000493)	1.80604622
85	Action tremor (HP:0002345)	1.80191944
86	Abnormality of serine family amino acid metabolism (HP:0010894)	1.77148210
87	Abnormality of glycine metabolism (HP:0010895)	1.77148210
88	Pancreatic cysts (HP:0001737)	1.75819183
89	Humeroradial synostosis (HP:0003041)	1.74839589
90	Synostosis involving the elbow (HP:0003938)	1.74839589
91	Neoplasm of head and neck (HP:0012288)	1.74726490
92	Esophageal neoplasm (HP:0100751)	1.74726490
93	Mitochondrial inheritance (HP:0001427)	1.73523345
94	Pendular nystagmus (HP:0012043)	1.72201608
95	Diaphragmatic weakness (HP:0009113)	1.71575694
96	Abnormality of vitamin B metabolism (HP:0004340)	1.71179491
97	Hyperglycinuria (HP:0003108)	1.71122024
98	Meningioma (HP:0002858)	1.71116987
99	Neoplasm of the rectum (HP:0100743)	1.69734626
100	Abolished electroretinogram (ERG) (HP:0000550)	1.69274970

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.67935041
2	MAP3K9	5.65101031
3	MAP3K13	5.54847873
4	ARAF	5.20140926
5	WEE1	3.40016947
6	LIMK1	2.87800880
7	VRK2	2.64873404
8	PLK4	2.60956677
9	MOS	2.51947766
10	RAF1	2.47572531
11	BRAF	2.32679210
12	NUAK1	2.21573129
13	BMPR1B	2.04189250
14	VRK1	1.95013113
15	KSR2	1.89708135
16	IRAK2	1.76053359
17	PAK2	1.61016801
18	NTRK3	1.60763146
19	YES1	1.60259737
20	IRAK1	1.50914317
21	TSSK6	1.49593334
22	PLK2	1.23031429
23	DMPK	1.21805111
24	EPHA3	1.18914735
25	EPHA4	1.18453695
26	ROCK2	1.14476421
27	STK16	1.06273729
28	PRKG2	1.03793450
29	DYRK2	1.02233255
30	TGFBR2	1.00051201
31	KSR1	0.99122847
32	MAPK15	0.96584993
33	TAOK3	0.91976168
34	PBK	0.91410163
35	NTRK2	0.90126710
36	NEK1	0.87840946
37	CDK3	0.84199854
38	CDC7	0.83448803
39	ABL2	0.81660244
40	MAPK13	0.80239051
41	ROCK1	0.79631962
42	ADRBK2	0.75334083
43	PASK	0.71165191
44	CAMKK2	0.67951469
45	ILK	0.65938797
46	PRKCG	0.65507416
47	MET	0.65053795
48	STK38L	0.64451008
49	CDC42BPA	0.64021144
50	TNIK	0.63328793
51	TLK1	0.57132885
52	MAP2K6	0.56859691
53	EIF2AK1	0.54123996
54	PRKCE	0.48127106
55	INSRR	0.47687337
56	GRK1	0.45645702
57	MAP2K1	0.44064838
58	MAP3K8	0.43176772
59	PRKCH	0.40763521
60	OXSR1	0.39814511
61	MST4	0.39264426
62	AKT3	0.37379790
63	PAK1	0.36740295
64	PTK2B	0.36738453
65	CAMK1D	0.34422658
66	PTK6	0.34390923
67	WNK3	0.32869495
68	MAP3K6	0.32388646
69	PRKACB	0.30780715
70	EPHA2	0.30685834
71	CAMK1G	0.30343760
72	PLK3	0.28447098
73	PRKCQ	0.27591480
74	PLK1	0.26466152
75	PRKD2	0.25695514
76	HIPK2	0.25354798
77	CAMK2D	0.23808720
78	PHKG1	0.23468756
79	PHKG2	0.23468756
80	ERBB4	0.22166159
81	CAMK2A	0.21798260
82	IGF1R	0.20675323
83	PDGFRB	0.19903083
84	PRKD3	0.19342256
85	FRK	0.19302773
86	MAP2K7	0.19164069
87	MINK1	0.18248288
88	NTRK1	0.17746155
89	STK39	0.16259551
90	ATM	0.12820505
91	CSNK2A2	0.12290920
92	PRKG1	0.11075635
93	CDK8	0.10961592
94	MAP3K12	0.09732181
95	PKN1	0.08626376
96	MAP3K1	0.08374424
97	MAP3K4	0.08262696
98	PDPK1	0.07581342
99	PRKCA	0.07420662
100	PRKCB	0.07045028

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.65594778
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.56293145
3	Selenocompound metabolism_Homo sapiens_hsa00450	3.39347502
4	Non-homologous end-joining_Homo sapiens_hsa03450	3.07797277
5	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.01151022
6	Homologous recombination_Homo sapiens_hsa03440	2.68784606
7	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.64048712
8	Propanoate metabolism_Homo sapiens_hsa00640	2.54947862
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.20466594
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.11521341
11	Glutathione metabolism_Homo sapiens_hsa00480	2.10146261
12	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.09554641
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.08238500
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.00595212
15	Sulfur relay system_Homo sapiens_hsa04122	1.97229042
16	Proteasome_Homo sapiens_hsa03050	1.80110771
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.64261355
18	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.61855761
19	Steroid biosynthesis_Homo sapiens_hsa00100	1.61676186
20	Chemical carcinogenesis_Homo sapiens_hsa05204	1.60409841
21	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.59688590
22	Folate biosynthesis_Homo sapiens_hsa00790	1.55400802
23	Parkinsons disease_Homo sapiens_hsa05012	1.51468364
24	Ribosome_Homo sapiens_hsa03010	1.50454887
25	Sulfur metabolism_Homo sapiens_hsa00920	1.45612899
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.40986219
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39697895
28	Fatty acid metabolism_Homo sapiens_hsa01212	1.35254274
29	Phototransduction_Homo sapiens_hsa04744	1.34962440
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.31058809
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.21317816
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.19510452
33	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.19096803
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.16264443
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.15603725
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.15357036
37	Protein export_Homo sapiens_hsa03060	1.15264209
38	Fatty acid degradation_Homo sapiens_hsa00071	1.08088810
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.05840984
40	Fatty acid elongation_Homo sapiens_hsa00062	1.05429485
41	RNA degradation_Homo sapiens_hsa03018	1.02433256
42	Fat digestion and absorption_Homo sapiens_hsa04975	1.00686552
43	Linoleic acid metabolism_Homo sapiens_hsa00591	1.00278521
44	RNA polymerase_Homo sapiens_hsa03020	1.00204935
45	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.98654630
46	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.95528033
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.94641158
48	PPAR signaling pathway_Homo sapiens_hsa03320	0.94081291
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90442897
50	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.90215319
51	Base excision repair_Homo sapiens_hsa03410	0.89515074
52	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.88552999
53	Pancreatic secretion_Homo sapiens_hsa04972	0.85888642
54	Huntingtons disease_Homo sapiens_hsa05016	0.84679639
55	Retinol metabolism_Homo sapiens_hsa00830	0.83489283
56	mRNA surveillance pathway_Homo sapiens_hsa03015	0.82282870
57	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79401372
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.78692153
59	Purine metabolism_Homo sapiens_hsa00230	0.74091040
60	Nicotine addiction_Homo sapiens_hsa05033	0.72659011
61	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.71277076
62	Metabolic pathways_Homo sapiens_hsa01100	0.67168854
63	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65840647
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.63523023
65	Alzheimers disease_Homo sapiens_hsa05010	0.60636790
66	Protein digestion and absorption_Homo sapiens_hsa04974	0.58582531
67	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56959572
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56401118
69	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55207277
70	Hippo signaling pathway_Homo sapiens_hsa04390	0.52623056
71	GABAergic synapse_Homo sapiens_hsa04727	0.49303289
72	RNA transport_Homo sapiens_hsa03013	0.48251572
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.47266858
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.46352771
75	Serotonergic synapse_Homo sapiens_hsa04726	0.44000388
76	Morphine addiction_Homo sapiens_hsa05032	0.43362314
77	Butanoate metabolism_Homo sapiens_hsa00650	0.42647014
78	Pyruvate metabolism_Homo sapiens_hsa00620	0.42308738
79	Insulin secretion_Homo sapiens_hsa04911	0.40318724
80	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.38379853
81	Nucleotide excision repair_Homo sapiens_hsa03420	0.34363279
82	Axon guidance_Homo sapiens_hsa04360	0.33928103
83	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.32985457
84	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.31963141
85	Long-term depression_Homo sapiens_hsa04730	0.31958505
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.29222861
87	Prion diseases_Homo sapiens_hsa05020	0.29142867
88	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.27837771
89	Vibrio cholerae infection_Homo sapiens_hsa05110	0.26594962
90	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.25148915
91	Melanoma_Homo sapiens_hsa05218	0.25064576
92	Renin-angiotensin system_Homo sapiens_hsa04614	0.24704807
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.24620416
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.23570548
95	Bile secretion_Homo sapiens_hsa04976	0.23103439
96	Gap junction_Homo sapiens_hsa04540	0.22276472
97	Salivary secretion_Homo sapiens_hsa04970	0.21827855
98	Alcoholism_Homo sapiens_hsa05034	0.21468570
99	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.21307743
100	Tight junction_Homo sapiens_hsa04530	0.18693678

KRT18P24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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