ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.99968754
2	viral transcription (GO:0019083)	6.18879294
3	regulation of mitochondrial translation (GO:0070129)	6.04139626
4	translational termination (GO:0006415)	5.95611261
5	ribosomal small subunit biogenesis (GO:0042274)	5.53789491
6	maturation of SSU-rRNA (GO:0030490)	5.50193326
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.40790171
8	translational elongation (GO:0006414)	5.36383012
9	protein targeting to ER (GO:0045047)	5.30921941
10	cotranslational protein targeting to membrane (GO:0006613)	5.30672150
11	ribosomal large subunit biogenesis (GO:0042273)	5.25398253
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.12451533
13	protein localization to endoplasmic reticulum (GO:0070972)	5.07326546
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.90610963
15	ATP synthesis coupled proton transport (GO:0015986)	4.90610963
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.83066632
17	translational initiation (GO:0006413)	4.63537536
18	viral life cycle (GO:0019058)	4.60011946
19	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.59950238
20	cellular protein complex disassembly (GO:0043624)	4.58582382
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.15052586
22	translation (GO:0006412)	4.12041192
23	protein complex biogenesis (GO:0070271)	4.00029011
24	regulation of oxidative phosphorylation (GO:0002082)	3.98805805
25	protein complex disassembly (GO:0043241)	3.95457464
26	ribonucleoprotein complex biogenesis (GO:0022613)	3.88614235
27	proteasome assembly (GO:0043248)	3.86383627
28	diaphragm development (GO:0060539)	3.84287537
29	macromolecular complex disassembly (GO:0032984)	3.77557603
30	cellular component biogenesis (GO:0044085)	3.70173092
31	protein targeting to membrane (GO:0006612)	3.65095697
32	respiratory electron transport chain (GO:0022904)	3.60919107
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.60233699
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.59546436
35	NADH dehydrogenase complex assembly (GO:0010257)	3.59546436
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.59546436
37	electron transport chain (GO:0022900)	3.58050668
38	rRNA modification (GO:0000154)	3.53968461
39	branched-chain amino acid catabolic process (GO:0009083)	3.51433012
40	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.50773235
41	L-phenylalanine metabolic process (GO:0006558)	3.50773235
42	protein neddylation (GO:0045116)	3.50182935
43	regulation of cellular respiration (GO:0043457)	3.46856051
44	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.46343926
45	skeletal muscle organ development (GO:0060538)	3.33822798
46	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.28705347
47	polyketide metabolic process (GO:0030638)	3.27131998
48	doxorubicin metabolic process (GO:0044598)	3.27131998
49	daunorubicin metabolic process (GO:0044597)	3.27131998
50	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.25501916
51	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.25501916
52	positive regulation of growth hormone secretion (GO:0060124)	3.21526037
53	nucleoside transport (GO:0015858)	3.21285184
54	positive regulation of prostaglandin secretion (GO:0032308)	3.20606953
55	ribosome assembly (GO:0042255)	3.20226411
56	DNA replication checkpoint (GO:0000076)	3.12292375
57	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.10421576
58	L-phenylalanine catabolic process (GO:0006559)	3.10421576
59	cullin deneddylation (GO:0010388)	3.10321638
60	regulation of DNA methylation (GO:0044030)	3.10108806
61	basic amino acid transport (GO:0015802)	3.09620247
62	mRNA catabolic process (GO:0006402)	3.08728008
63	pseudouridine synthesis (GO:0001522)	3.07602474
64	regulation of gonadotropin secretion (GO:0032276)	3.06761298
65	homocysteine metabolic process (GO:0050667)	3.03678239
66	protein targeting to mitochondrion (GO:0006626)	2.99208798
67	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.97759331
68	establishment of viral latency (GO:0019043)	2.97042898
69	water-soluble vitamin biosynthetic process (GO:0042364)	2.96573907
70	glycerophospholipid catabolic process (GO:0046475)	2.95702159
71	aminoglycoside antibiotic metabolic process (GO:0030647)	2.95153346
72	chaperone-mediated protein transport (GO:0072321)	2.93948656
73	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.90591667
74	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.90054020
75	DNA damage response, detection of DNA damage (GO:0042769)	2.87791744
76	intestinal epithelial cell development (GO:0060576)	2.85161361
77	ribosome biogenesis (GO:0042254)	2.85125011
78	RNA catabolic process (GO:0006401)	2.84126003
79	regulation of cellular amino acid metabolic process (GO:0006521)	2.83370936
80	protein deneddylation (GO:0000338)	2.82833221
81	rRNA methylation (GO:0031167)	2.82783814
82	hydrogen ion transmembrane transport (GO:1902600)	2.82488822
83	establishment of protein localization to mitochondrion (GO:0072655)	2.80420326
84	protein localization to mitochondrion (GO:0070585)	2.78937690
85	terpenoid biosynthetic process (GO:0016114)	2.77374000
86	purine ribonucleotide transport (GO:0015868)	2.77010953
87	establishment of integrated proviral latency (GO:0075713)	2.74572933
88	formation of translation preinitiation complex (GO:0001731)	2.74110946
89	spliceosomal snRNP assembly (GO:0000387)	2.73954390
90	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.72190225
91	cobalamin metabolic process (GO:0009235)	2.71877759
92	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.71033843
93	regulation of prostaglandin secretion (GO:0032306)	2.70935386
94	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.70348518
95	termination of RNA polymerase III transcription (GO:0006386)	2.70348518
96	respiratory chain complex IV assembly (GO:0008535)	2.69387979
97	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.67617075
98	establishment of protein localization to membrane (GO:0090150)	2.67599138
99	rRNA processing (GO:0006364)	2.66237586
100	protein autoprocessing (GO:0016540)	2.64806620

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.64136362
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.27196688
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.93359882
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.90919865
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.85396988
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.73046943
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.69572622
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.24035612
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.19254363
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.99588554
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.94358765
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.87956001
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.78489166
14	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.70952661
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.63956352
16	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.60519280
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.59093374
18	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.50209139
19	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.30779727
20	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.29532716
21	XRN2_22483619_ChIP-Seq_HELA_Human	2.00892759
22	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.98930246
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.98478249
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.94460539
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.87738827
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.85665147
27	TTF2_22483619_ChIP-Seq_HELA_Human	1.83250174
28	DCP1A_22483619_ChIP-Seq_HELA_Human	1.80034987
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.79625703
30	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.76211585
31	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.74473294
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.72790425
33	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.70388915
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.69077249
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63426478
36	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.59989971
37	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.57375273
38	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.49971940
39	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.48717926
40	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.46904634
41	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.46878948
42	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.46680116
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.45161524
44	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.43411231
45	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.42487366
46	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.41725532
47	AR_21909140_ChIP-Seq_LNCAP_Human	1.41521335
48	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.37892851
49	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.37582508
50	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.37080823
51	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.34731362
52	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.33731453
53	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.30537187
54	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.30154926
55	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.29772888
56	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.27813033
57	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.26882565
58	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.26882565
59	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.26882565
60	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.23692978
61	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.23310207
62	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.22203392
63	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.22192189
64	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.19071824
65	SOX2_18692474_ChIP-Seq_MEFs_Mouse	1.18764238
66	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.17004887
67	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.16228676
68	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.12520649
69	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.11461258
70	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.10902033
71	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.10083081
72	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.09844620
73	AR_20517297_ChIP-Seq_VCAP_Human	1.04717076
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01937837
75	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01265201
76	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.00934997
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97168354
78	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.97047320
79	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96878128
80	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.96671181
81	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.94847219
82	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.94810819
83	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.92101275
84	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.90833416
85	EOMES_21245162_ChIP-Seq_HESCs_Human	0.90312769
86	GATA4_25053715_ChIP-Seq_YYC3_Human	0.89431855
87	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.88882262
88	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.86921081
89	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.85253144
90	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.84503935
91	KDM5A_27292631_Chip-Seq_BREAST_Human	0.83657909
92	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.81817935
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.80184473
94	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.79596044
95	POU5F1_18692474_ChIP-Seq_MESCs_Mouse	0.79115631
96	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.78841260
97	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.78811531
98	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.77574969
99	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.74881922
100	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.74396032

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	7.74121118
2	MP0009379_abnormal_foot_pigmentation	5.65351263
3	MP0002163_abnormal_gland_morphology	3.70899593
4	MP0002837_dystrophic_cardiac_calcinosis	2.65973358
5	MP0004147_increased_porphyrin_level	2.54785306
6	MP0002653_abnormal_ependyma_morphology	2.39554473
7	MP0005377_hearing/vestibular/ear_phenot	2.36405125
8	MP0003878_abnormal_ear_physiology	2.36405125
9	MP0001293_anophthalmia	2.35912590
10	MP0005379_endocrine/exocrine_gland_phen	2.31693574
11	MP0003693_abnormal_embryo_hatching	2.16442208
12	MP0008789_abnormal_olfactory_epithelium	2.09886951
13	MP0002277_abnormal_respiratory_mucosa	1.95150439
14	MP0003186_abnormal_redox_activity	1.90913203
15	MP0003806_abnormal_nucleotide_metabolis	1.84918018
16	MP0002736_abnormal_nociception_after	1.81897779
17	MP0000647_abnormal_sebaceous_gland	1.80943867
18	MP0005332_abnormal_amino_acid	1.79786686
19	MP0005085_abnormal_gallbladder_physiolo	1.78512535
20	MP0005084_abnormal_gallbladder_morpholo	1.72836101
21	MP0010386_abnormal_urinary_bladder	1.72599095
22	MP0004957_abnormal_blastocyst_morpholog	1.71650953
23	MP0002938_white_spotting	1.67651575
24	MP0004019_abnormal_vitamin_homeostasis	1.66583863
25	MP0002132_abnormal_respiratory_system	1.61125046
26	MP0000613_abnormal_salivary_gland	1.55223733
27	MP0005499_abnormal_olfactory_system	1.54278000
28	MP0005394_taste/olfaction_phenotype	1.54278000
29	MP0003718_maternal_effect	1.48823752
30	MP0001764_abnormal_homeostasis	1.47760408
31	MP0001666_abnormal_nutrient_absorption	1.47101509
32	MP0008932_abnormal_embryonic_tissue	1.47072776
33	MP0008877_abnormal_DNA_methylation	1.37874685
34	MP0008058_abnormal_DNA_repair	1.32971342
35	MP0005670_abnormal_white_adipose	1.32104880
36	MP0003123_paternal_imprinting	1.27579833
37	MP0003937_abnormal_limbs/digits/tail_de	1.27420474
38	MP0006036_abnormal_mitochondrial_physio	1.24975855
39	MP0000566_synostosis	1.23928468
40	MP0008872_abnormal_physiological_respon	1.22171133
41	MP0002697_abnormal_eye_size	1.21672933
42	MP0010352_gastrointestinal_tract_polyps	1.19279425
43	MP0004264_abnormal_extraembryonic_tissu	1.17200088
44	MP0005408_hypopigmentation	1.17097243
45	MP0002254_reproductive_system_inflammat	1.16123001
46	MP0010234_abnormal_vibrissa_follicle	1.15845139
47	MP0001756_abnormal_urination	1.14204908
48	MP0001286_abnormal_eye_development	1.12875248
49	MP0001485_abnormal_pinna_reflex	1.10318220
50	MP0003941_abnormal_skin_development	1.09423100
51	MP0002234_abnormal_pharynx_morphology	1.07906712
52	MP0001968_abnormal_touch/_nociception	1.07607303
53	MP0006035_abnormal_mitochondrial_morpho	1.06068736
54	MP0003136_yellow_coat_color	1.05788623
55	MP0009643_abnormal_urine_homeostasis	1.04233787
56	MP0010030_abnormal_orbit_morphology	1.00234731
57	MP0005365_abnormal_bile_salt	0.99193512
58	MP0010094_abnormal_chromosome_stability	0.97274016
59	MP0002233_abnormal_nose_morphology	0.96945081
60	MP0000631_abnormal_neuroendocrine_gland	0.94938681
61	MP0003567_abnormal_fetal_cardiomyocyte	0.92104519
62	MP0003119_abnormal_digestive_system	0.91878672
63	MP0009697_abnormal_copulation	0.91564380
64	MP0005636_abnormal_mineral_homeostasis	0.90417546
65	MP0005220_abnormal_exocrine_pancreas	0.90079720
66	MP0002796_impaired_skin_barrier	0.89902915
67	MP0002085_abnormal_embryonic_tissue	0.88957184
68	MP0001697_abnormal_embryo_size	0.88494617
69	MP0003890_abnormal_embryonic-extraembry	0.88465998
70	MP0003938_abnormal_ear_development	0.88448212
71	MP0005501_abnormal_skin_physiology	0.88260323
72	MP0000383_abnormal_hair_follicle	0.87342684
73	MP0000049_abnormal_middle_ear	0.86941955
74	MP0000678_abnormal_parathyroid_gland	0.86047460
75	MP0008875_abnormal_xenobiotic_pharmacok	0.84144833
76	MP0001529_abnormal_vocalization	0.83643750
77	MP0003936_abnormal_reproductive_system	0.83358639
78	MP0010678_abnormal_skin_adnexa	0.82773335
79	MP0000372_irregular_coat_pigmentation	0.82577582
80	MP0002098_abnormal_vibrissa_morphology	0.81649716
81	MP0002084_abnormal_developmental_patter	0.81417289
82	MP0003942_abnormal_urinary_system	0.80885935
83	MP0001542_abnormal_bone_strength	0.79816331
84	MP0002210_abnormal_sex_determination	0.79771964
85	MP0000639_abnormal_adrenal_gland	0.78194850
86	MP0000462_abnormal_digestive_system	0.77694646
87	MP0004185_abnormal_adipocyte_glucose	0.76567629
88	MP0000428_abnormal_craniofacial_morphol	0.75945045
89	MP0001849_ear_inflammation	0.75251561
90	MP0002102_abnormal_ear_morphology	0.73745504
91	MP0001730_embryonic_growth_arrest	0.71516382
92	MP0000762_abnormal_tongue_morphology	0.71311791
93	MP0002876_abnormal_thyroid_physiology	0.68952704
94	MP0005174_abnormal_tail_pigmentation	0.67339317
95	MP0005197_abnormal_uvea_morphology	0.67019496
96	MP0003077_abnormal_cell_cycle	0.66898390
97	MP0000490_abnormal_crypts_of	0.65782818
98	MP0000467_abnormal_esophagus_morphology	0.65411249
99	MP0005075_abnormal_melanosome_morpholog	0.61301444
100	MP0002111_abnormal_tail_morphology	0.60909408

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.40474518
2	Reticulocytopenia (HP:0001896)	4.83762373
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.80167512
4	Acute encephalopathy (HP:0006846)	4.64889051
5	Progressive macrocephaly (HP:0004481)	4.45242457
6	Septo-optic dysplasia (HP:0100842)	4.15889357
7	Mitochondrial inheritance (HP:0001427)	3.89320282
8	Cerebral edema (HP:0002181)	3.85174285
9	Increased CSF lactate (HP:0002490)	3.45878699
10	Macrocytic anemia (HP:0001972)	3.40848806
11	Abnormality of cells of the erythroid lineage (HP:0012130)	3.38464151
12	Leukodystrophy (HP:0002415)	3.34442586
13	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.31954164
14	Microvesicular hepatic steatosis (HP:0001414)	3.28698881
15	Abnormal number of erythroid precursors (HP:0012131)	3.21941214
16	Hepatocellular necrosis (HP:0001404)	3.15664969
17	Maternal diabetes (HP:0009800)	3.02406365
18	Adrenal hypoplasia (HP:0000835)	2.94368392
19	Lethargy (HP:0001254)	2.90185135
20	Hepatic necrosis (HP:0002605)	2.88680000
21	Paralysis (HP:0003470)	2.85317449
22	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.82682793
23	Abnormal trabecular bone morphology (HP:0100671)	2.81814718
24	Oral leukoplakia (HP:0002745)	2.77576661
25	Rough bone trabeculation (HP:0100670)	2.75799924
26	Hyperglycinemia (HP:0002154)	2.74523665
27	Abnormality of methionine metabolism (HP:0010901)	2.73547051
28	Abnormality of magnesium homeostasis (HP:0004921)	2.69599856
29	Patent foramen ovale (HP:0001655)	2.66569152
30	Respiratory failure (HP:0002878)	2.64481351
31	Hydroureter (HP:0000072)	2.59524787
32	Renal tubular acidosis (HP:0001947)	2.57278264
33	Abnormality of serum amino acid levels (HP:0003112)	2.52496572
34	Glycosuria (HP:0003076)	2.50279433
35	Abnormality of urine glucose concentration (HP:0011016)	2.50279433
36	3-Methylglutaconic aciduria (HP:0003535)	2.49219877
37	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.48868332
38	Methylmalonic aciduria (HP:0012120)	2.46418292
39	Hypomagnesemia (HP:0002917)	2.45505969
40	Bilateral sensorineural hearing impairment (HP:0008619)	2.42403718
41	Lactic acidosis (HP:0003128)	2.39693693
42	Optic disc pallor (HP:0000543)	2.37164342
43	Methylmalonic acidemia (HP:0002912)	2.34766655
44	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.32361546
45	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.32361546
46	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.30538029
47	Stenosis of the external auditory canal (HP:0000402)	2.24916717
48	Shoulder girdle muscle weakness (HP:0003547)	2.24051109
49	Metabolic acidosis (HP:0001942)	2.22875899
50	Cerebral hypomyelination (HP:0006808)	2.20287629
51	Aplastic anemia (HP:0001915)	2.19278362
52	Absent septum pellucidum (HP:0001331)	2.18956184
53	Amelogenesis imperfecta (HP:0000705)	2.18398973
54	Increased serum lactate (HP:0002151)	2.17940129
55	Median cleft lip (HP:0000161)	2.17886497
56	Abnormality of glycine metabolism (HP:0010895)	2.16328788
57	Abnormality of serine family amino acid metabolism (HP:0010894)	2.16328788
58	Exercise intolerance (HP:0003546)	2.15148523
59	Increased circulating renin level (HP:0000848)	2.13030713
60	Pallor (HP:0000980)	2.10194932
61	Colon cancer (HP:0003003)	2.10172104
62	Increased hepatocellular lipid droplets (HP:0006565)	2.09191665
63	Urethral obstruction (HP:0000796)	2.08070089
64	Anomalous pulmonary venous return (HP:0010772)	2.07002024
65	Proximal tubulopathy (HP:0000114)	2.06580707
66	Renal tubular dysfunction (HP:0000124)	2.04331923
67	Lipid accumulation in hepatocytes (HP:0006561)	2.04070138
68	Hyperphosphaturia (HP:0003109)	2.04058871
69	Gout (HP:0001997)	2.01796823
70	Renal Fanconi syndrome (HP:0001994)	2.01593881
71	Hyperglycinuria (HP:0003108)	1.99572205
72	Ketosis (HP:0001946)	1.98132104
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.97758605
74	Abnormal number of incisors (HP:0011064)	1.96079139
75	Optic nerve hypoplasia (HP:0000609)	1.91704025
76	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.90367743
77	Dicarboxylic aciduria (HP:0003215)	1.90367743
78	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88928869
79	True hermaphroditism (HP:0010459)	1.87862321
80	Vomiting (HP:0002013)	1.87555517
81	Spastic diplegia (HP:0001264)	1.86319229
82	Poor suck (HP:0002033)	1.84970841
83	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.84064307
84	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.83153888
85	Submucous cleft hard palate (HP:0000176)	1.82373009
86	Testicular atrophy (HP:0000029)	1.82325269
87	Absent thumb (HP:0009777)	1.79248686
88	Congenital, generalized hypertrichosis (HP:0004540)	1.78131105
89	Opisthotonus (HP:0002179)	1.76145610
90	Hypoplasia of the uterus (HP:0000013)	1.75732130
91	Pancytopenia (HP:0001876)	1.75610075
92	Abnormality of the pulmonary veins (HP:0011718)	1.75494664
93	Polydipsia (HP:0001959)	1.74487483
94	Abnormal drinking behavior (HP:0030082)	1.74487483
95	Bifid uvula (HP:0000193)	1.73470625
96	Birth length less than 3rd percentile (HP:0003561)	1.72782574
97	Abnormality of the hip-girdle musculature (HP:0001445)	1.72670036
98	Abnormality of the musculature of the pelvis (HP:0001469)	1.72670036
99	Ileus (HP:0002595)	1.71427384
100	Aplasia/hypoplasia of the uterus (HP:0008684)	1.70380700

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	5.02014276
2	STK39	4.26432204
3	MST4	3.67675161
4	TLK1	3.26456464
5	WNK4	3.13052866
6	OXSR1	3.05094347
7	VRK2	2.95470011
8	PBK	2.90983831
9	PDK2	2.79742512
10	NEK1	2.75961203
11	BUB1	2.66756536
12	TNIK	2.64764897
13	VRK1	2.10044956
14	CDC7	2.00921023
15	LMTK2	1.94705675
16	NME2	1.90676486
17	RPS6KB2	1.88756536
18	ZAK	1.85779184
19	MAP2K7	1.71067175
20	EIF2AK3	1.60875568
21	BRSK2	1.53574786
22	NLK	1.49024086
23	CASK	1.48936172
24	PLK4	1.33980229
25	TIE1	1.32587832
26	BMPR1B	1.27493122
27	TRIM28	1.25637208
28	DYRK2	1.23745609
29	NUAK1	1.22236330
30	PASK	1.22022637
31	EIF2AK1	1.20547340
32	ILK	1.17783299
33	PAK4	1.15202701
34	LRRK2	1.09667529
35	NME1	1.02336417
36	LIMK1	1.01222531
37	STK38L	0.98165462
38	PRKG2	0.95912252
39	ABL2	0.95639264
40	PIM2	0.94563692
41	MAP3K9	0.92665096
42	CAMKK2	0.89399311
43	MST1R	0.88893150
44	CDK19	0.88821394
45	DAPK3	0.86687037
46	PRKCI	0.86654878
47	EPHA4	0.84083646
48	GRK1	0.82769064
49	WNK3	0.82531259
50	STK16	0.82125232
51	ERBB3	0.80475371
52	MAP2K2	0.80390284
53	ARAF	0.79563816
54	AURKA	0.78807373
55	BRSK1	0.77906587
56	MAP3K12	0.74953353
57	MYLK	0.74368303
58	ERBB4	0.67959327
59	PINK1	0.67446418
60	PLK1	0.67157845
61	CDK8	0.62793031
62	TESK1	0.60872758
63	BMPR2	0.59254386
64	RPS6KA5	0.58471428
65	MAP3K8	0.58284917
66	AURKB	0.57209106
67	PHKG2	0.55916809
68	PHKG1	0.55916809
69	PAK1	0.55614295
70	AKT2	0.55371886
71	PIK3CA	0.51401140
72	MAP2K6	0.49067810
73	STK10	0.47304242
74	EIF2AK2	0.46423713
75	PLK3	0.46259515
76	CHEK2	0.45233469
77	MAP3K4	0.44943255
78	BCKDK	0.43981104
79	TAF1	0.43373488
80	WEE1	0.41998540
81	SRPK1	0.41086358
82	PTK6	0.40212540
83	TSSK6	0.35862365
84	PTK2	0.33710783
85	PRKCE	0.33054561
86	CSNK2A1	0.32731192
87	PIM1	0.32317086
88	ADRBK2	0.31602072
89	KDR	0.30318500
90	CAMK2G	0.29253118
91	EPHB2	0.28929915
92	MAP3K2	0.28524100
93	ERBB2	0.27852993
94	MAP2K4	0.27605682
95	PRKCG	0.26496494
96	CAMK1	0.26281594
97	PRKCD	0.24727457
98	ADRBK1	0.23182477
99	CSNK2A2	0.22436227
100	NEK2	0.21150818

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.48568302
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.84171809
3	Proteasome_Homo sapiens_hsa03050	3.71510187
4	Parkinsons disease_Homo sapiens_hsa05012	3.11474619
5	Huntingtons disease_Homo sapiens_hsa05016	2.25870557
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.04732977
7	RNA polymerase_Homo sapiens_hsa03020	1.99798096
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.88678346
9	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.88109532
10	Folate biosynthesis_Homo sapiens_hsa00790	1.87103672
11	Collecting duct acid secretion_Homo sapiens_hsa04966	1.85961787
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.80021564
13	Alzheimers disease_Homo sapiens_hsa05010	1.78279912
14	Sulfur relay system_Homo sapiens_hsa04122	1.77638596
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.65969560
16	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.62579587
17	Protein export_Homo sapiens_hsa03060	1.60267037
18	Fatty acid elongation_Homo sapiens_hsa00062	1.59134415
19	Glutathione metabolism_Homo sapiens_hsa00480	1.58090594
20	Galactose metabolism_Homo sapiens_hsa00052	1.54810169
21	Fat digestion and absorption_Homo sapiens_hsa04975	1.54360536
22	Basal transcription factors_Homo sapiens_hsa03022	1.53173008
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.49894384
24	Pancreatic secretion_Homo sapiens_hsa04972	1.41960220
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39919108
26	DNA replication_Homo sapiens_hsa03030	1.35368059
27	Spliceosome_Homo sapiens_hsa03040	1.34340145
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.31291210
29	Vibrio cholerae infection_Homo sapiens_hsa05110	1.29381389
30	Homologous recombination_Homo sapiens_hsa03440	1.29005079
31	Mismatch repair_Homo sapiens_hsa03430	1.27880958
32	RNA transport_Homo sapiens_hsa03013	1.24013965
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.22774428
34	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.22072912
35	Base excision repair_Homo sapiens_hsa03410	1.20990609
36	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.19862384
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19498241
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18369195
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.17207718
40	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.12940575
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.12911686
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.12566767
43	RNA degradation_Homo sapiens_hsa03018	1.11103360
44	Tight junction_Homo sapiens_hsa04530	1.09762893
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.08915918
46	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.04914967
47	Fatty acid degradation_Homo sapiens_hsa00071	1.04423699
48	Selenocompound metabolism_Homo sapiens_hsa00450	1.03996327
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.03757286
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.97080481
51	Propanoate metabolism_Homo sapiens_hsa00640	0.95559865
52	Carbon metabolism_Homo sapiens_hsa01200	0.94795020
53	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.94635266
54	Sulfur metabolism_Homo sapiens_hsa00920	0.90652517
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89753916
56	Tyrosine metabolism_Homo sapiens_hsa00350	0.87199050
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.86500544
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.84635399
59	Metabolic pathways_Homo sapiens_hsa01100	0.84376546
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82122558
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79002671
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78215967
63	Protein digestion and absorption_Homo sapiens_hsa04974	0.78076352
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74447646
65	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.72643176
66	Butanoate metabolism_Homo sapiens_hsa00650	0.72528604
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72016430
68	Fanconi anemia pathway_Homo sapiens_hsa03460	0.71791105
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71559218
70	One carbon pool by folate_Homo sapiens_hsa00670	0.71314579
71	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.70445576
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.69771025
73	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.65939831
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65032433
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.63078568
76	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.62079418
77	Retinol metabolism_Homo sapiens_hsa00830	0.61901148
78	Purine metabolism_Homo sapiens_hsa00230	0.61761415
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.61038014
80	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.58810710
81	Pentose phosphate pathway_Homo sapiens_hsa00030	0.58443586
82	Peroxisome_Homo sapiens_hsa04146	0.57787041
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.56624661
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55685498
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.53217130
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.51824529
87	Nitrogen metabolism_Homo sapiens_hsa00910	0.50827944
88	Renin-angiotensin system_Homo sapiens_hsa04614	0.49483668
89	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.40888278
90	Tryptophan metabolism_Homo sapiens_hsa00380	0.40341404
91	Phototransduction_Homo sapiens_hsa04744	0.39516706
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39040396
93	Thyroid cancer_Homo sapiens_hsa05216	0.36989592
94	Phenylalanine metabolism_Homo sapiens_hsa00360	0.36308057
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35490682
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.33727693
97	Alcoholism_Homo sapiens_hsa05034	0.33311778
98	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.32045401
99	Basal cell carcinoma_Homo sapiens_hsa05217	0.29557181
100	Caffeine metabolism_Homo sapiens_hsa00232	0.28528413

KRT18P25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »