ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	folic acid-containing compound biosynthetic process (GO:0009396)	9.00490778
2	homocysteine metabolic process (GO:0050667)	8.97477411
3	regulation of plasminogen activation (GO:0010755)	8.46691916
4	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	8.26840023
5	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	8.26840023
6	sulfur amino acid catabolic process (GO:0000098)	7.57653686
7	cysteine metabolic process (GO:0006534)	7.13115446
8	pteridine-containing compound biosynthetic process (GO:0042559)	6.55293686
9	white fat cell differentiation (GO:0050872)	6.53665161
10	purine nucleotide salvage (GO:0032261)	6.48963702
11	negative regulation of DNA biosynthetic process (GO:2000279)	6.35974015
12	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	6.31379509
13	mitochondrial RNA metabolic process (GO:0000959)	6.13842364
14	desmosome organization (GO:0002934)	6.09588812
15	adenosine metabolic process (GO:0046085)	6.03358978
16	microtubule nucleation (GO:0007020)	5.94065591
17	heme transport (GO:0015886)	5.28978052
18	alternative mRNA splicing, via spliceosome (GO:0000380)	5.27891979
19	rRNA methylation (GO:0031167)	5.20039981
20	L-serine metabolic process (GO:0006563)	5.16812941
21	IMP biosynthetic process (GO:0006188)	4.94665176
22	inner ear receptor cell development (GO:0060119)	4.93489692
23	rRNA modification (GO:0000154)	4.92349981
24	galactose catabolic process (GO:0019388)	4.90283077
25	folic acid-containing compound metabolic process (GO:0006760)	4.78796020
26	tetrahydrofolate metabolic process (GO:0046653)	4.78199257
27	protein-cofactor linkage (GO:0018065)	4.57227351
28	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	4.56834382
29	positive regulation of endothelial cell differentiation (GO:0045603)	4.53568110
30	energy homeostasis (GO:0097009)	4.41592961
31	serine family amino acid biosynthetic process (GO:0009070)	4.39251345
32	regulation of vitamin D biosynthetic process (GO:0060556)	4.37992469
33	phosphatidylglycerol biosynthetic process (GO:0006655)	4.37694715
34	negative regulation of keratinocyte proliferation (GO:0010839)	4.37469687
35	nucleoside transmembrane transport (GO:1901642)	4.37413814
36	regulation of gonadotropin secretion (GO:0032276)	4.31846371
37	negative regulation of telomerase activity (GO:0051974)	4.28613682
38	cartilage morphogenesis (GO:0060536)	4.25571772
39	regulation of tight junction assembly (GO:2000810)	4.24528266
40	CENP-A containing nucleosome assembly (GO:0034080)	4.23524825
41	negative regulation of Ras GTPase activity (GO:0034261)	4.22931949
42	aminoglycoside antibiotic metabolic process (GO:0030647)	4.22662495
43	galactose metabolic process (GO:0006012)	4.20993284
44	protein-chromophore linkage (GO:0018298)	4.17963353
45	pteridine-containing compound metabolic process (GO:0042558)	4.14741165
46	cell migration involved in heart development (GO:0060973)	4.13936147
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.12170837
48	NADH dehydrogenase complex assembly (GO:0010257)	4.12170837
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.12170837
50	negative regulation of catenin import into nucleus (GO:0035414)	4.11305638
51	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	4.06771131
52	transcription from mitochondrial promoter (GO:0006390)	4.06220142
53	histone H4-K12 acetylation (GO:0043983)	4.05945459
54	cochlea development (GO:0090102)	3.97357181
55	IMP metabolic process (GO:0046040)	3.95544955
56	tRNA modification (GO:0006400)	3.95144689
57	nucleotide salvage (GO:0043173)	3.94219735
58	primary amino compound metabolic process (GO:1901160)	3.94075602
59	chromatin remodeling at centromere (GO:0031055)	3.87372462
60	response to vitamin A (GO:0033189)	3.84657143
61	regulation of vitamin metabolic process (GO:0030656)	3.84435532
62	regulation of sequestering of triglyceride (GO:0010889)	3.84102655
63	polyamine biosynthetic process (GO:0006596)	3.83497701
64	organic cation transport (GO:0015695)	3.79566958
65	iron coordination entity transport (GO:1901678)	3.77355520
66	pseudouridine synthesis (GO:0001522)	3.77124081
67	DNA ligation (GO:0006266)	3.76212329
68	folic acid transport (GO:0015884)	3.74728415
69	sulfur amino acid biosynthetic process (GO:0000097)	3.72123903
70	artery smooth muscle contraction (GO:0014824)	3.69819888
71	folic acid metabolic process (GO:0046655)	3.67483878
72	ribosome biogenesis (GO:0042254)	3.59092618
73	glycoside metabolic process (GO:0016137)	3.52138204
74	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	3.46031527
75	serine family amino acid catabolic process (GO:0009071)	3.40685723
76	behavioral defense response (GO:0002209)	3.39052081
77	behavioral fear response (GO:0001662)	3.39052081
78	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.26880468
79	ATP hydrolysis coupled proton transport (GO:0015991)	3.26880468
80	regulation of endothelial cell differentiation (GO:0045601)	3.26343802
81	polyamine metabolic process (GO:0006595)	3.26197247
82	tRNA processing (GO:0008033)	3.23931024
83	inner mitochondrial membrane organization (GO:0007007)	3.23546753
84	negative regulation of interleukin-1 beta production (GO:0032691)	3.18609217
85	innervation (GO:0060384)	3.18036595
86	DNA replication-independent nucleosome assembly (GO:0006336)	3.13384352
87	DNA replication-independent nucleosome organization (GO:0034724)	3.13384352
88	histone exchange (GO:0043486)	3.12663968
89	nucleoside transport (GO:0015858)	3.11462027
90	protein complex biogenesis (GO:0070271)	3.11199968
91	regulation of G0 to G1 transition (GO:0070316)	3.10900426
92	tonic smooth muscle contraction (GO:0014820)	3.10900073
93	GMP metabolic process (GO:0046037)	3.07408440
94	growth hormone secretion (GO:0030252)	3.07280399
95	sulfur amino acid metabolic process (GO:0000096)	3.03176112
96	one-carbon metabolic process (GO:0006730)	3.00057279
97	placenta development (GO:0001890)	2.99103971
98	G-protein coupled receptor internalization (GO:0002031)	2.96903588
99	guanosine-containing compound biosynthetic process (GO:1901070)	2.92176801
100	cellular iron ion homeostasis (GO:0006879)	2.91185810

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.14654368
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.68756131
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.95433156
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.75056414
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.72658853
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.51509368
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.41030343
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.35054506
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.28438901
10	ZNF263_19887448_ChIP-Seq_K562_Human	2.17315975
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.17142777
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.09348276
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06344512
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.06319095
15	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.01975208
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	11.9760260
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.96973497
18	GABP_19822575_ChIP-Seq_HepG2_Human	1.79903346
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.76415327
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.75496457
21	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.74217435
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.74042037
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.72255511
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.70789542
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.60668588
26	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.59995287
27	VDR_22108803_ChIP-Seq_LS180_Human	1.55074308
28	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.53413545
29	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.52150473
30	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.50399315
31	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.47455023
32	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.44777676
33	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.43685486
34	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.43591239
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.40774759
36	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.36118617
37	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.35098634
38	AR_21909140_ChIP-Seq_LNCAP_Human	1.34974797
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.34247556
40	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.28800042
41	NCOR_22424771_ChIP-Seq_293T_Human	1.25864526
42	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.25048920
43	XRN2_22483619_ChIP-Seq_HELA_Human	1.19699750
44	FLI1_21867929_ChIP-Seq_CD8_Mouse	1.19478011
45	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.18838103
46	CDX2_22108803_ChIP-Seq_LS180_Human	1.17071406
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.16671989
48	P68_20966046_ChIP-Seq_HELA_Human	1.11710668
49	CIITA_25753668_ChIP-Seq_RAJI_Human	1.10701899
50	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.06867499
51	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.05338575
52	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.04876659
53	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.04332501
54	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.04081294
55	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03852678
56	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03616649
57	DCP1A_22483619_ChIP-Seq_HELA_Human	1.03596437
58	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.02343798
59	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.02133127
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01818158
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.01010063
62	STAT1_20625510_ChIP-Seq_HELA_Human	1.00834999
63	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.00379776
64	KDM5A_27292631_Chip-Seq_BREAST_Human	0.97195855
65	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.97143317
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96192640
67	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.92315066
68	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.91394984
69	P300_27268052_Chip-Seq_Bcells_Human	0.91232864
70	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.90602376
71	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.89931751
72	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.88668602
73	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.87821809
74	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.86772854
75	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.85477068
76	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.83857899
77	CEBPB_22108803_ChIP-Seq_LS180_Human	0.82714308
78	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.80311042
79	HOXB7_26014856_ChIP-Seq_BT474_Human	0.79458754
80	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.79168906
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.78542821
82	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.78420546
83	CTCF_20526341_ChIP-Seq_ESCs_Human	0.78416239
84	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.78327329
85	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.76367995
86	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.76230200
87	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.75900924
88	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.75814137
89	TP53_22127205_ChIP-Seq_IMR90_Human	0.75463106
90	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.74580646
91	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.74297037
92	OCT4_20526341_ChIP-Seq_ESCs_Human	0.74166520
93	E2F1_20622854_ChIP-Seq_HELA_Human	0.73548982
94	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.71769719
95	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.71460565
96	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.71010278
97	BCOR_27268052_Chip-Seq_Bcells_Human	0.70279326
98	TTF2_22483619_ChIP-Seq_HELA_Human	0.69411759
99	GATA4_25053715_ChIP-Seq_YYC3_Human	0.69316449
100	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	0.68555282

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	5.46244857
2	MP0005646_abnormal_pituitary_gland	5.28292200
3	MP0005360_urolithiasis	5.27522856
4	MP0008995_early_reproductive_senescence	4.21868946
5	MP0000013_abnormal_adipose_tissue	3.58054369
6	MP0003183_abnormal_peptide_metabolism	3.38412461
7	MP0002396_abnormal_hematopoietic_system	3.25559310
8	MP0004885_abnormal_endolymph	3.08072149
9	MP0003705_abnormal_hypodermis_morpholog	2.89015777
10	MP0001661_extended_life_span	2.89012645
11	MP0002736_abnormal_nociception_after	2.86491978
12	MP0002139_abnormal_hepatobiliary_system	2.85281499
13	MP0004185_abnormal_adipocyte_glucose	2.61413866
14	MP0003806_abnormal_nucleotide_metabolis	2.61389963
15	MP0002938_white_spotting	2.52735001
16	MP0000516_abnormal_urinary_system	2.36276745
17	MP0005367_renal/urinary_system_phenotyp	2.36276745
18	MP0003045_fibrosis	2.36251930
19	MP0004147_increased_porphyrin_level	2.34703490
20	MP0008872_abnormal_physiological_respon	2.14364445
21	MP0003186_abnormal_redox_activity	2.12776411
22	MP0001986_abnormal_taste_sensitivity	1.97646164
23	MP0001764_abnormal_homeostasis	1.95491354
24	MP0005332_abnormal_amino_acid	1.94138676
25	MP0003786_premature_aging	1.93301802
26	MP0003724_increased_susceptibility_to	1.83723246
27	MP0001968_abnormal_touch/_nociception	1.72618885
28	MP0000003_abnormal_adipose_tissue	1.70921010
29	MP0002095_abnormal_skin_pigmentation	1.54206466
30	MP0005085_abnormal_gallbladder_physiolo	1.52450217
31	MP0008875_abnormal_xenobiotic_pharmacok	1.39551614
32	MP0002735_abnormal_chemical_nociception	1.35018073
33	MP0008058_abnormal_DNA_repair	1.34488376
34	MP0004130_abnormal_muscle_cell	1.27765196
35	MP0000647_abnormal_sebaceous_gland	1.24941933
36	MP0004043_abnormal_pH_regulation	1.24163417
37	MP0004133_heterotaxia	1.22443941
38	MP0010094_abnormal_chromosome_stability	1.19728749
39	MP0000534_abnormal_ureter_morphology	1.16400678
40	MP0002138_abnormal_hepatobiliary_system	1.16051282
41	MP0000631_abnormal_neuroendocrine_gland	1.14756772
42	MP0009697_abnormal_copulation	1.13416870
43	MP0003111_abnormal_nucleus_morphology	1.09588018
44	MP0002132_abnormal_respiratory_system	1.07067763
45	MP0005084_abnormal_gallbladder_morpholo	1.06804207
46	MP0005551_abnormal_eye_electrophysiolog	1.00785225
47	MP0006035_abnormal_mitochondrial_morpho	0.98486322
48	MP0009643_abnormal_urine_homeostasis	0.97140433
49	MP0004233_abnormal_muscle_weight	0.93463254
50	MP0005636_abnormal_mineral_homeostasis	0.92167433
51	MP0006292_abnormal_olfactory_placode	0.92011967
52	MP0001944_abnormal_pancreas_morphology	0.91445837
53	MP0002160_abnormal_reproductive_system	0.91095760
54	MP0001756_abnormal_urination	0.89127163
55	MP0002210_abnormal_sex_determination	0.87631626
56	MP0002269_muscular_atrophy	0.86459273
57	MP0000678_abnormal_parathyroid_gland	0.85256443
58	MP0000751_myopathy	0.83916674
59	MP0000653_abnormal_sex_gland	0.82645480
60	MP0005410_abnormal_fertilization	0.81949745
61	MP0005319_abnormal_enzyme/_coenzyme	0.81263091
62	MP0001145_abnormal_male_reproductive	0.77915753
63	MP0005376_homeostasis/metabolism_phenot	0.74664216
64	MP0000026_abnormal_inner_ear	0.73405956
65	MP0002069_abnormal_eating/drinking_beha	0.72989668
66	MP0000372_irregular_coat_pigmentation	0.72360148
67	MP0003693_abnormal_embryo_hatching	0.70393266
68	MP0000750_abnormal_muscle_regeneration	0.67518965
69	MP0004019_abnormal_vitamin_homeostasis	0.66421832
70	MP0003698_abnormal_male_reproductive	0.64377636
71	MP0005220_abnormal_exocrine_pancreas	0.63317192
72	MP0001440_abnormal_grooming_behavior	0.61975119
73	MP0001929_abnormal_gametogenesis	0.61596432
74	MP0001270_distended_abdomen	0.60893722
75	MP0003567_abnormal_fetal_cardiomyocyte	0.60824288
76	MP0005647_abnormal_sex_gland	0.59956567
77	MP0009765_abnormal_xenobiotic_induced	0.57811331
78	MP0001243_abnormal_dermal_layer	0.57378898
79	MP0001963_abnormal_hearing_physiology	0.57364261
80	MP0001486_abnormal_startle_reflex	0.57181787
81	MP0006036_abnormal_mitochondrial_physio	0.55152933
82	MP0003942_abnormal_urinary_system	0.54836118
83	MP0001119_abnormal_female_reproductive	0.54729561
84	MP0005389_reproductive_system_phenotype	0.54352787
85	MP0000371_diluted_coat_color	0.54265378
86	MP0005253_abnormal_eye_physiology	0.53545004
87	MP0002796_impaired_skin_barrier	0.52539278
88	MP0001666_abnormal_nutrient_absorption	0.52325957
89	MP0001919_abnormal_reproductive_system	0.52269261
90	MP0005377_hearing/vestibular/ear_phenot	0.52026553
91	MP0003878_abnormal_ear_physiology	0.52026553
92	MP0008057_abnormal_DNA_replication	0.50821856
93	MP0000747_muscle_weakness	0.49577986
94	MP0002332_abnormal_exercise_endurance	0.48817175
95	MP0000762_abnormal_tongue_morphology	0.48756983
96	MP0008873_increased_physiological_sensi	0.46806519
97	MP0002060_abnormal_skin_morphology	0.45919642
98	MP0006276_abnormal_autonomic_nervous	0.45881193
99	MP0000749_muscle_degeneration	0.45660516
100	MP0001765_abnormal_ion_homeostasis	0.43337542

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	9.55653063
2	Hyperalaninemia (HP:0003348)	9.55653063
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	9.55653063
4	Constricted visual fields (HP:0001133)	6.07425706
5	Congenital sensorineural hearing impairment (HP:0008527)	5.31753360
6	Esophageal varix (HP:0002040)	5.18600344
7	Spontaneous hematomas (HP:0007420)	4.76962179
8	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.72815665
9	Birth length less than 3rd percentile (HP:0003561)	4.42063555
10	White forelock (HP:0002211)	4.32303299
11	Abnormality of the fetal cardiovascular system (HP:0010948)	4.31783447
12	Abnormal umbilical cord blood vessels (HP:0011403)	4.31783447
13	Single umbilical artery (HP:0001195)	4.31783447
14	Oligomenorrhea (HP:0000876)	4.09971423
15	Patchy hypopigmentation of hair (HP:0011365)	3.89868786
16	Abnormality of serum amino acid levels (HP:0003112)	3.63299108
17	Homocystinuria (HP:0002156)	3.47959637
18	Abnormality of homocysteine metabolism (HP:0010919)	3.47959637
19	Anorexia (HP:0002039)	3.47832580
20	Conjugated hyperbilirubinemia (HP:0002908)	3.44474122
21	Conjunctival telangiectasia (HP:0000524)	3.14074442
22	Poor speech (HP:0002465)	3.04223594
23	Myocardial infarction (HP:0001658)	2.98179145
24	Generalized aminoaciduria (HP:0002909)	2.93208087
25	Tubulointerstitial nephritis (HP:0001970)	2.76131612
26	Abnormality of the umbilical cord (HP:0010881)	2.74434945
27	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.74361718
28	Ileus (HP:0002595)	2.68845577
29	Action tremor (HP:0002345)	2.68754285
30	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.64681242
31	Pulmonary embolism (HP:0002204)	2.58892819
32	Hypochromic microcytic anemia (HP:0004840)	2.57989711
33	Attenuation of retinal blood vessels (HP:0007843)	2.52511199
34	Cone-rod dystrophy (HP:0000548)	2.48570063
35	Abnormality of the phalanges of the hallux (HP:0010057)	2.48553580
36	Cortical visual impairment (HP:0100704)	2.47263374
37	Heterochromia iridis (HP:0001100)	2.45921774
38	Chronic otitis media (HP:0000389)	2.45318209
39	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.44350364
40	Hypoalphalipoproteinemia (HP:0003233)	2.43095629
41	Reduced subcutaneous adipose tissue (HP:0003758)	2.39845331
42	Toxemia of pregnancy (HP:0100603)	2.38809949
43	Myopathic facies (HP:0002058)	2.35984913
44	Maternal diabetes (HP:0009800)	2.34572834
45	Chorioretinal atrophy (HP:0000533)	2.33396826
46	Microcytic anemia (HP:0001935)	2.29978394
47	Visceral angiomatosis (HP:0100761)	2.27111680
48	Clonus (HP:0002169)	2.25477290
49	Chronic hepatic failure (HP:0100626)	2.25001541
50	Nausea (HP:0002018)	2.23214591
51	Fatigue (HP:0012378)	2.20824299
52	Hypoplastic left heart (HP:0004383)	2.14009053
53	Metabolic acidosis (HP:0001942)	2.13885572
54	Arteriovenous malformation (HP:0100026)	2.12473961
55	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.10967285
56	Type 2 muscle fiber atrophy (HP:0003554)	2.08487911
57	Thrombophlebitis (HP:0004418)	2.07617970
58	Paralysis (HP:0003470)	2.06437366
59	Increased serum lactate (HP:0002151)	2.01816669
60	Elevated erythrocyte sedimentation rate (HP:0003565)	2.00664158
61	Increased serum pyruvate (HP:0003542)	2.00129161
62	Abnormality of the neuromuscular junction (HP:0003398)	1.99856504
63	Fatigable weakness (HP:0003473)	1.99856504
64	Duplication of thumb phalanx (HP:0009942)	1.99677954
65	Decreased subcutaneous fat (HP:0001002)	1.98673400
66	Insulin-resistant diabetes mellitus (HP:0000831)	1.98559658
67	Hemangiomatosis (HP:0007461)	1.97327917
68	Pigmentary retinal degeneration (HP:0001146)	1.96773532
69	Polygenic inheritance (HP:0010982)	1.96721375
70	Duplicated collecting system (HP:0000081)	1.95444375
71	Biconcave vertebral bodies (HP:0004586)	1.93977915
72	Abnormality of the renal collecting system (HP:0004742)	1.93736913
73	Tetany (HP:0001281)	1.93584081
74	Short tibia (HP:0005736)	1.93452979
75	Abolished electroretinogram (ERG) (HP:0000550)	1.92581291
76	Bone marrow hypocellularity (HP:0005528)	1.89324899
77	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87505279
78	Long clavicles (HP:0000890)	1.86278676
79	Lactic acidosis (HP:0003128)	1.86256331
80	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.86161872
81	Hyperglycinemia (HP:0002154)	1.85978458
82	Abnormality of the carotid arteries (HP:0005344)	1.84729865
83	Methylmalonic acidemia (HP:0002912)	1.83912075
84	Proximal tubulopathy (HP:0000114)	1.83132726
85	Abnormal tarsal ossification (HP:0008369)	1.83080765
86	Pendular nystagmus (HP:0012043)	1.82927318
87	Intention tremor (HP:0002080)	1.80459411
88	Premature graying of hair (HP:0002216)	1.79639664
89	Muscle fiber atrophy (HP:0100295)	1.77787432
90	Abnormality of subcutaneous fat tissue (HP:0001001)	1.77708660
91	Hyperphosphaturia (HP:0003109)	1.77571198
92	Short 1st metacarpal (HP:0010034)	1.76711210
93	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.76711210
94	Hypopigmentation of the fundus (HP:0007894)	1.74614172
95	Abnormality of DNA repair (HP:0003254)	1.71415645
96	Abnormalities of placenta or umbilical cord (HP:0001194)	1.69507242
97	Portal hypertension (HP:0001409)	1.64652177
98	Hypoplastic heart (HP:0001961)	1.63519189
99	Chromsome breakage (HP:0040012)	1.63455930
100	Hypomagnesemia (HP:0002917)	1.63401461

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP2K3	5.26509607
2	MAP3K3	4.92697933
3	VRK2	3.32118581
4	RPS6KB2	3.28393326
5	ACVR1B	3.07065685
6	NTRK3	2.93625340
7	CDK19	2.93415363
8	JAK3	2.93029383
9	CDK9	2.80506417
10	FGR	2.77536380
11	NUAK1	2.29072831
12	NTRK2	2.27334646
13	BCKDK	2.16321235
14	SGK494	1.88036822
15	SGK223	1.88036822
16	PDK2	1.84794649
17	EPHA2	1.82114954
18	WNK4	1.71711020
19	OXSR1	1.61108165
20	EPHB2	1.55024226
21	EIF2AK1	1.54359624
22	SGK2	1.47061799
23	VRK1	1.34319420
24	ADRBK1	1.32307838
25	CCNB1	1.25717517
26	NEK6	1.25669945
27	AURKA	1.24762208
28	FLT3	1.23524494
29	CSNK1A1	1.13168209
30	SCYL2	1.09735919
31	PBK	1.08844874
32	LMTK2	1.07871351
33	MAP4K1	1.06252153
34	FRK	0.99869136
35	STK39	0.98253822
36	TIE1	0.92350646
37	SGK3	0.90836309
38	MAP2K1	0.88820446
39	PHKG1	0.88009697
40	PHKG2	0.88009697
41	CAMK1	0.84123342
42	MAP3K11	0.83459833
43	CAMK2D	0.79941222
44	CDK7	0.78889594
45	PLK4	0.77030305
46	CAMK2G	0.76072697
47	CAMK2B	0.75226285
48	DYRK2	0.71181855
49	ATR	0.67339917
50	PINK1	0.67040652
51	GRK6	0.65935793
52	AURKB	0.65277996
53	CHEK2	0.64992032
54	GRK1	0.64772005
55	PLK1	0.61347145
56	TAOK3	0.60809900
57	KDR	0.58877979
58	RPS6KB1	0.57990884
59	PAK4	0.57398280
60	SRPK1	0.57209978
61	NEK2	0.53378604
62	PRKCE	0.51998885
63	PRKCD	0.51792550
64	EIF2AK3	0.51407601
65	PRKCQ	0.51388029
66	STK10	0.49733881
67	ADRBK2	0.49553100
68	INSRR	0.49150889
69	PRKCI	0.48830632
70	DAPK1	0.48018343
71	RPS6KA1	0.42064687
72	KIT	0.41803034
73	EGFR	0.41784621
74	CSNK2A1	0.40488619
75	PRKCA	0.38499132
76	MTOR	0.37523040
77	ERN1	0.35996380
78	STK3	0.35398313
79	BRSK2	0.34787856
80	TAF1	0.34715752
81	SGK1	0.34385154
82	PRKD3	0.33836459
83	PIK3CG	0.33737676
84	NME2	0.33542525
85	PRKG2	0.33068971
86	CAMK2A	0.32626126
87	TLK1	0.32510576
88	CSNK2A2	0.31728922
89	ZAK	0.31454512
90	ABL2	0.31103724
91	CDK2	0.30577640
92	IKBKB	0.30307116
93	PLK3	0.29878346
94	LATS1	0.29772804
95	PIM1	0.29557595
96	CDC7	0.29269206
97	CSNK1G3	0.25380904
98	PRKACB	0.25237107
99	INSR	0.23455288
100	PAK1	0.23373719

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	5.18550324
2	Collecting duct acid secretion_Homo sapiens_hsa04966	3.96920722
3	Arginine biosynthesis_Homo sapiens_hsa00220	3.38159579
4	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.77302918
5	Sulfur relay system_Homo sapiens_hsa04122	2.68280682
6	Sulfur metabolism_Homo sapiens_hsa00920	2.45800728
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.27594690
8	Regulation of autophagy_Homo sapiens_hsa04140	2.09510980
9	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.06543476
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.03224560
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.00816053
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.96197714
13	DNA replication_Homo sapiens_hsa03030	1.91532792
14	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.90222657
15	Galactose metabolism_Homo sapiens_hsa00052	1.85441526
16	Proteasome_Homo sapiens_hsa03050	1.63182718
17	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.59825664
18	Base excision repair_Homo sapiens_hsa03410	1.55570172
19	Folate biosynthesis_Homo sapiens_hsa00790	1.54123096
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.54034102
21	GABAergic synapse_Homo sapiens_hsa04727	1.53131110
22	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.52466008
23	Vibrio cholerae infection_Homo sapiens_hsa05110	1.51018621
24	Morphine addiction_Homo sapiens_hsa05032	1.48270972
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.46068417
26	Nicotine addiction_Homo sapiens_hsa05033	1.45687094
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.45450734
28	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.40644808
29	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.37569758
30	Homologous recombination_Homo sapiens_hsa03440	1.32998459
31	Spliceosome_Homo sapiens_hsa03040	1.32441353
32	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.31582331
33	Mismatch repair_Homo sapiens_hsa03430	1.29395559
34	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.29063049
35	Basal transcription factors_Homo sapiens_hsa03022	1.27660786
36	RNA transport_Homo sapiens_hsa03013	1.18360764
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.16944037
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13223567
39	RNA degradation_Homo sapiens_hsa03018	1.11872479
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.11653488
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.10000830
42	Asthma_Homo sapiens_hsa05310	1.09598414
43	Retinol metabolism_Homo sapiens_hsa00830	1.02475185
44	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.02279222
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.01069913
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.99830877
47	Peroxisome_Homo sapiens_hsa04146	0.98953880
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.97966590
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.97003864
50	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.96998403
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.96944339
52	Fanconi anemia pathway_Homo sapiens_hsa03460	0.96796235
53	RNA polymerase_Homo sapiens_hsa03020	0.90390047
54	ABC transporters_Homo sapiens_hsa02010	0.89713380
55	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88624478
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.86208477
57	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.83746022
58	Non-homologous end-joining_Homo sapiens_hsa03450	0.82542800
59	Graft-versus-host disease_Homo sapiens_hsa05332	0.82302604
60	Glutathione metabolism_Homo sapiens_hsa00480	0.79552507
61	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75041458
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74764618
63	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.73760115
64	Ribosome_Homo sapiens_hsa03010	0.72893000
65	Serotonergic synapse_Homo sapiens_hsa04726	0.71935137
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71827855
67	Allograft rejection_Homo sapiens_hsa05330	0.71364875
68	Metabolic pathways_Homo sapiens_hsa01100	0.71115628
69	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.69960720
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68925240
71	Taste transduction_Homo sapiens_hsa04742	0.65649694
72	Butanoate metabolism_Homo sapiens_hsa00650	0.65610838
73	Purine metabolism_Homo sapiens_hsa00230	0.64417045
74	Type I diabetes mellitus_Homo sapiens_hsa04940	0.63195202
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.62539155
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60175421
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59484904
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.59081992
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.58431387
80	Olfactory transduction_Homo sapiens_hsa04740	0.56757642
81	Huntingtons disease_Homo sapiens_hsa05016	0.55407474
82	Circadian entrainment_Homo sapiens_hsa04713	0.52106257
83	Other glycan degradation_Homo sapiens_hsa00511	0.48608428
84	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.47928463
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46583859
86	Fatty acid elongation_Homo sapiens_hsa00062	0.46525560
87	Glutamatergic synapse_Homo sapiens_hsa04724	0.46516271
88	Alcoholism_Homo sapiens_hsa05034	0.45371981
89	Parkinsons disease_Homo sapiens_hsa05012	0.45356208
90	Linoleic acid metabolism_Homo sapiens_hsa00591	0.44086570
91	Dopaminergic synapse_Homo sapiens_hsa04728	0.40967257
92	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.40050436
93	Carbon metabolism_Homo sapiens_hsa01200	0.39944008
94	Ether lipid metabolism_Homo sapiens_hsa00565	0.39715660
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.39055836
96	Tryptophan metabolism_Homo sapiens_hsa00380	0.35141027
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34189779
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31809167
99	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.24744736
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24530860

KRT18P26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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