ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	6.24407982
2	chromosome organization involved in meiosis (GO:0070192)	5.66195214
3	synaptonemal complex assembly (GO:0007130)	5.15067058
4	male meiosis I (GO:0007141)	4.99832291
5	synaptonemal complex organization (GO:0070193)	4.76736952
6	DNA synthesis involved in DNA repair (GO:0000731)	4.62074082
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.57709480
8	meiosis I (GO:0007127)	4.43939153
9	regulation of oxidative phosphorylation (GO:0002082)	4.42144110
10	piRNA metabolic process (GO:0034587)	4.36510576
11	male meiosis (GO:0007140)	4.16577442
12	ribosomal small subunit biogenesis (GO:0042274)	4.07528107
13	DNA methylation involved in gamete generation (GO:0043046)	3.94537807
14	ribosomal small subunit assembly (GO:0000028)	3.92065992
15	chaperone-mediated protein transport (GO:0072321)	3.85111233
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.82383811
17	regulation of mitochondrial translation (GO:0070129)	3.79361017
18	DNA replication checkpoint (GO:0000076)	3.72677965
19	proteasome assembly (GO:0043248)	3.71857130
20	viral transcription (GO:0019083)	3.71529039
21	translational termination (GO:0006415)	3.69709968
22	meiotic nuclear division (GO:0007126)	3.63074729
23	ATP synthesis coupled proton transport (GO:0015986)	3.50118486
24	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.50118486
25	CENP-A containing nucleosome assembly (GO:0034080)	3.48082761
26	artery smooth muscle contraction (GO:0014824)	3.48037459
27	rRNA modification (GO:0000154)	3.47311086
28	ribosome assembly (GO:0042255)	3.46238099
29	chromatin remodeling at centromere (GO:0031055)	3.42223320
30	regulation of cellular respiration (GO:0043457)	3.39309967
31	pseudouridine synthesis (GO:0001522)	3.37495931
32	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.36280851
33	prostaglandin biosynthetic process (GO:0001516)	3.34755722
34	prostanoid biosynthetic process (GO:0046457)	3.34755722
35	translational initiation (GO:0006413)	3.33832662
36	translational elongation (GO:0006414)	3.31222433
37	cotranslational protein targeting to membrane (GO:0006613)	3.29645382
38	protein targeting to ER (GO:0045047)	3.29054309
39	maturation of SSU-rRNA (GO:0030490)	3.24215338
40	translation (GO:0006412)	3.22904099
41	ribonucleoprotein complex biogenesis (GO:0022613)	3.19855960
42	intestinal epithelial cell development (GO:0060576)	3.18439330
43	meiotic cell cycle process (GO:1903046)	3.18091941
44	protein localization to endoplasmic reticulum (GO:0070972)	3.17125400
45	reciprocal meiotic recombination (GO:0007131)	3.15234142
46	reciprocal DNA recombination (GO:0035825)	3.15234142
47	histone exchange (GO:0043486)	3.14939425
48	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.13574000
49	regulation of cellular amino acid metabolic process (GO:0006521)	3.10718628
50	formation of translation preinitiation complex (GO:0001731)	3.10066680
51	telomere maintenance via semi-conservative replication (GO:0032201)	3.08976567
52	ribosomal large subunit biogenesis (GO:0042273)	3.08312899
53	mitotic metaphase plate congression (GO:0007080)	3.07829942
54	hepatocyte apoptotic process (GO:0097284)	3.02846109
55	ribosome biogenesis (GO:0042254)	3.00916886
56	protein autoprocessing (GO:0016540)	2.98067516
57	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.97401018
58	viral life cycle (GO:0019058)	2.96469754
59	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.94143435
60	cellular protein complex disassembly (GO:0043624)	2.93744723
61	rRNA processing (GO:0006364)	2.91881024
62	cellular component biogenesis (GO:0044085)	2.91764374
63	tRNA methylation (GO:0030488)	2.89366144
64	fusion of sperm to egg plasma membrane (GO:0007342)	2.88613341
65	rRNA methylation (GO:0031167)	2.87517954
66	establishment of integrated proviral latency (GO:0075713)	2.85607097
67	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.83474216
68	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.83366751
69	tonic smooth muscle contraction (GO:0014820)	2.82267770
70	protein targeting to mitochondrion (GO:0006626)	2.82152762
71	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.81947051
72	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.81122700
73	rRNA metabolic process (GO:0016072)	2.80945951
74	L-serine metabolic process (GO:0006563)	2.79973341
75	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.79878883
76	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.79878883
77	CTP biosynthetic process (GO:0006241)	2.77380255
78	CTP metabolic process (GO:0046036)	2.77380255
79	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.76516138
80	mesonephros development (GO:0001823)	2.75678357
81	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.73413047
82	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.73413047
83	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.73413047
84	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.73265236
85	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.72311426
86	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.71653631
87	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.71653631
88	norepinephrine metabolic process (GO:0042415)	2.70385599
89	DNA strand elongation involved in DNA replication (GO:0006271)	2.69689422
90	DNA replication-dependent nucleosome organization (GO:0034723)	2.68832161
91	DNA replication-dependent nucleosome assembly (GO:0006335)	2.68832161
92	desmosome organization (GO:0002934)	2.68423371
93	GTP biosynthetic process (GO:0006183)	2.67990632
94	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.65981639
95	establishment of protein localization to mitochondrion (GO:0072655)	2.65655752
96	keratinocyte development (GO:0003334)	2.65111134
97	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.64919042
98	protein localization to mitochondrion (GO:0070585)	2.64709531
99	DNA strand elongation (GO:0022616)	2.64105088
100	UTP biosynthetic process (GO:0006228)	2.61694533

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.09573560
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.99709117
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.35070217
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.31995275
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.30859952
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.24389121
7	E2F7_22180533_ChIP-Seq_HELA_Human	3.21822945
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.03581528
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.98671629
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.96017541
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.94576104
12	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.78325958
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.76212061
14	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.75844144
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.73950607
16	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.64250087
17	DCP1A_22483619_ChIP-Seq_HELA_Human	2.58936857
18	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.58423329
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.51414108
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.50707366
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.43803070
22	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.28116218
23	AR_21909140_ChIP-Seq_LNCAP_Human	2.23632059
24	GABP_19822575_ChIP-Seq_HepG2_Human	2.19259076
25	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.19061120
26	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.17144753
27	XRN2_22483619_ChIP-Seq_HELA_Human	2.07727669
28	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.05696604
29	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.05162964
30	ZNF263_19887448_ChIP-Seq_K562_Human	2.01962668
31	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.98083708
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.94802062
33	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.93599815
34	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.91248733
35	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.89729576
36	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.86941597
37	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.78115114
38	KDM5A_27292631_Chip-Seq_BREAST_Human	1.75513314
39	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.69408904
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.69371215
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.67736733
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.67592428
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.64673082
44	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.61652352
45	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.55558580
46	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.51453630
47	VDR_23849224_ChIP-Seq_CD4+_Human	1.50355206
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.48438350
49	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.46902650
50	ELK1_19687146_ChIP-ChIP_HELA_Human	1.43946171
51	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.39246874
52	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.39072252
53	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.37294725
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36866297
55	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.36598707
56	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.32488844
57	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.30467807
58	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.27732739
59	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.25715967
60	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.25240876
61	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.22951045
62	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.21786640
63	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.21340686
64	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.19861035
65	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.15631488
66	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.14256192
67	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.13764643
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.13334539
69	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.12641399
70	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.12576379
71	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.12311827
72	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.12264383
73	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.08249866
74	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.07942324
75	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.07713108
76	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.07660602
77	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.06716402
78	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05566066
79	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.03180095
80	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.02111612
81	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.01462431
82	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.00526351
83	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.00137971
84	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.99132027
85	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.98434872
86	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.96847609
87	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.96705761
88	ATF3_27146783_Chip-Seq_COLON_Human	0.94665145
89	RACK7_27058665_Chip-Seq_MCF-7_Human	0.94116496
90	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.92434119
91	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.91982331
92	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.91637627
93	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91587774
94	MYC_18940864_ChIP-ChIP_HL60_Human	0.88867422
95	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.88550905
96	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.88302361
97	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.86311346
98	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.85054336
99	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.84671966
100	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.84595110

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.03135800
2	MP0003693_abnormal_embryo_hatching	3.85144068
3	MP0003123_paternal_imprinting	3.37821851
4	MP0009379_abnormal_foot_pigmentation	2.94649001
5	MP0008058_abnormal_DNA_repair	2.93291806
6	MP0004957_abnormal_blastocyst_morpholog	2.77459972
7	MP0002160_abnormal_reproductive_system	2.75353607
8	MP0000383_abnormal_hair_follicle	2.28276652
9	MP0006292_abnormal_olfactory_placode	2.26833439
10	MP0002796_impaired_skin_barrier	2.24720791
11	MP0003195_calcinosis	2.18260112
12	MP0010234_abnormal_vibrissa_follicle	2.14811720
13	MP0005377_hearing/vestibular/ear_phenot	2.14236710
14	MP0003878_abnormal_ear_physiology	2.14236710
15	MP0000566_synostosis	2.12052161
16	MP0003111_abnormal_nucleus_morphology	2.06271323
17	MP0002210_abnormal_sex_determination	2.05330363
18	MP0010678_abnormal_skin_adnexa	2.01566372
19	MP0000678_abnormal_parathyroid_gland	1.96939962
20	MP0003806_abnormal_nucleotide_metabolis	1.96527075
21	MP0010094_abnormal_chromosome_stability	1.95607912
22	MP0009697_abnormal_copulation	1.89895617
23	MP0010352_gastrointestinal_tract_polyps	1.87178488
24	MP0003283_abnormal_digestive_organ	1.83870491
25	MP0002098_abnormal_vibrissa_morphology	1.81731440
26	MP0003718_maternal_effect	1.80632595
27	MP0004264_abnormal_extraembryonic_tissu	1.74509009
28	MP0005083_abnormal_biliary_tract	1.73289298
29	MP0001929_abnormal_gametogenesis	1.73269436
30	MP0005501_abnormal_skin_physiology	1.72177318
31	MP0003315_abnormal_perineum_morphology	1.71288258
32	MP0005389_reproductive_system_phenotype	1.63136218
33	MP0005451_abnormal_body_composition	1.63010581
34	MP0010030_abnormal_orbit_morphology	1.62051135
35	MP0003941_abnormal_skin_development	1.61358191
36	MP0001145_abnormal_male_reproductive	1.58436712
37	MP0003186_abnormal_redox_activity	1.52738029
38	MP0000537_abnormal_urethra_morphology	1.52435133
39	MP0003077_abnormal_cell_cycle	1.51209615
40	MP0005670_abnormal_white_adipose	1.49317861
41	MP0006035_abnormal_mitochondrial_morpho	1.48420054
42	MP0000579_abnormal_nail_morphology	1.47222829
43	MP0000358_abnormal_cell_content/	1.46668335
44	MP0000653_abnormal_sex_gland	1.41550330
45	MP0000427_abnormal_hair_cycle	1.40975983
46	MP0004019_abnormal_vitamin_homeostasis	1.39767408
47	MP0003787_abnormal_imprinting	1.29272839
48	MP0008932_abnormal_embryonic_tissue	1.28928055
49	MP0000647_abnormal_sebaceous_gland	1.28460873
50	MP0005410_abnormal_fertilization	1.24476851
51	MP0000372_irregular_coat_pigmentation	1.23617516
52	MP0001697_abnormal_embryo_size	1.22417166
53	MP0003698_abnormal_male_reproductive	1.20148425
54	MP0003786_premature_aging	1.19878716
55	MP0000467_abnormal_esophagus_morphology	1.16387606
56	MP0001730_embryonic_growth_arrest	1.10421281
57	MP0001666_abnormal_nutrient_absorption	1.08941713
58	MP0001919_abnormal_reproductive_system	1.05632728
59	MP0006036_abnormal_mitochondrial_physio	1.04794854
60	MP0001661_extended_life_span	1.04441215
61	MP0000462_abnormal_digestive_system	1.01935785
62	MP0010771_integument_phenotype	1.00283041
63	MP0000350_abnormal_cell_proliferation	0.99222465
64	MP0003936_abnormal_reproductive_system	0.98630874
65	MP0004233_abnormal_muscle_weight	0.97910636
66	MP0002254_reproductive_system_inflammat	0.97399973
67	MP0001293_anophthalmia	0.97039612
68	MP0001672_abnormal_embryogenesis/_devel	0.95673315
69	MP0005380_embryogenesis_phenotype	0.95673315
70	MP0004147_increased_porphyrin_level	0.94812125
71	MP0003937_abnormal_limbs/digits/tail_de	0.93318341
72	MP0001119_abnormal_female_reproductive	0.91322412
73	MP0002085_abnormal_embryonic_tissue	0.90416597
74	MP0000627_abnormal_mammary_gland	0.88772435
75	MP0002161_abnormal_fertility/fecundity	0.88634653
76	MP0008875_abnormal_xenobiotic_pharmacok	0.88591911
77	MP0003119_abnormal_digestive_system	0.88590587
78	MP0002080_prenatal_lethality	0.87254759
79	MP0004197_abnormal_fetal_growth/weight/	0.86537174
80	MP0005636_abnormal_mineral_homeostasis	0.85050685
81	MP0001727_abnormal_embryo_implantation	0.84883313
82	MP0005408_hypopigmentation	0.84267847
83	MP0003942_abnormal_urinary_system	0.84155001
84	MP0001216_abnormal_epidermal_layer	0.82968879
85	MP0003699_abnormal_female_reproductive	0.82823706
86	MP0002697_abnormal_eye_size	0.80802674
87	MP0005332_abnormal_amino_acid	0.80501331
88	MP0002822_catalepsy	0.80132854
89	MP0002088_abnormal_embryonic_growth/wei	0.78598786
90	MP0003984_embryonic_growth_retardation	0.77375721
91	MP0002111_abnormal_tail_morphology	0.76794845
92	MP0003638_abnormal_response/metabolism_	0.76434905
93	MP0009053_abnormal_anal_canal	0.74823642
94	MP0002086_abnormal_extraembryonic_tissu	0.73344636
95	MP0002060_abnormal_skin_morphology	0.72867900
96	MP0002084_abnormal_developmental_patter	0.72444780
97	MP0004782_abnormal_surfactant_physiolog	0.72300133
98	MP0002938_white_spotting	0.72297828
99	MP0000377_abnormal_hair_follicle	0.72006916
100	MP0000762_abnormal_tongue_morphology	0.71352422

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal mitochondria in muscle tissue (HP:0008316)	3.26410086
2	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.24846153
3	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.24846153
4	Adrenal hypoplasia (HP:0000835)	3.20539793
5	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.17463978
6	Acute necrotizing encephalopathy (HP:0006965)	3.15656626
7	Hyperphosphatemia (HP:0002905)	2.97256370
8	Increased CSF lactate (HP:0002490)	2.94092934
9	Renal tubular acidosis (HP:0001947)	2.91315504
10	Acute encephalopathy (HP:0006846)	2.87147065
11	Hypoglycemic seizures (HP:0002173)	2.86981717
12	Abnormality of magnesium homeostasis (HP:0004921)	2.82451717
13	Hyperinsulinemic hypoglycemia (HP:0000825)	2.78782711
14	Micronodular cirrhosis (HP:0001413)	2.77665772
15	Progressive macrocephaly (HP:0004481)	2.68795336
16	Mitochondrial inheritance (HP:0001427)	2.66822525
17	Microvesicular hepatic steatosis (HP:0001414)	2.66507280
18	Prominent metopic ridge (HP:0005487)	2.65087297
19	Pili torti (HP:0003777)	2.64232438
20	Woolly hair (HP:0002224)	2.60458262
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.59738723
22	Sparse eyelashes (HP:0000653)	2.57840372
23	Chromsome breakage (HP:0040012)	2.57502534
24	Hepatocellular necrosis (HP:0001404)	2.57410312
25	Hypomagnesemia (HP:0002917)	2.53832857
26	Abnormality of the metopic suture (HP:0005556)	2.53335540
27	Congenital, generalized hypertrichosis (HP:0004540)	2.53277597
28	Hypoplastic pelvis (HP:0008839)	2.53023394
29	Absent thumb (HP:0009777)	2.51433058
30	Reticulocytopenia (HP:0001896)	2.49640170
31	Abnormality of the preputium (HP:0100587)	2.49434530
32	Microglossia (HP:0000171)	2.48130790
33	Increased intramyocellular lipid droplets (HP:0012240)	2.46281356
34	Increased circulating renin level (HP:0000848)	2.45581302
35	Hepatic necrosis (HP:0002605)	2.42358004
36	Increased hepatocellular lipid droplets (HP:0006565)	2.42333126
37	Hypoglycemic coma (HP:0001325)	2.39681339
38	Methylmalonic acidemia (HP:0002912)	2.37977885
39	Azoospermia (HP:0000027)	2.37858742
40	Increased serum lactate (HP:0002151)	2.36121642
41	Ectopic kidney (HP:0000086)	2.34423909
42	Rough bone trabeculation (HP:0100670)	2.34016842
43	Hyperglycinemia (HP:0002154)	2.33777672
44	Lactic acidosis (HP:0003128)	2.31186432
45	Renal tubular dysfunction (HP:0000124)	2.29065373
46	Lipid accumulation in hepatocytes (HP:0006561)	2.28788163
47	Multiple enchondromatosis (HP:0005701)	2.28513018
48	Lethargy (HP:0001254)	2.26326387
49	Symptomatic seizures (HP:0011145)	2.22974751
50	Ketoacidosis (HP:0001993)	2.22842304
51	Patent foramen ovale (HP:0001655)	2.21361527
52	Redundant skin (HP:0001582)	2.20797875
53	Cerebral edema (HP:0002181)	2.17937600
54	Abnormality of the umbilical cord (HP:0010881)	2.13909572
55	Tetany (HP:0001281)	2.13860062
56	Abnormal pancreas size (HP:0012094)	2.13802982
57	Oral leukoplakia (HP:0002745)	2.11986408
58	Hyperphosphaturia (HP:0003109)	2.10320810
59	Macrocytic anemia (HP:0001972)	2.09940605
60	Ketosis (HP:0001946)	2.08746467
61	Type I transferrin isoform profile (HP:0003642)	2.07031708
62	Poor suck (HP:0002033)	2.05393584
63	Septate vagina (HP:0001153)	2.04717963
64	Increased muscle lipid content (HP:0009058)	2.04514559
65	Amelogenesis imperfecta (HP:0000705)	1.96716728
66	Bicornuate uterus (HP:0000813)	1.95900004
67	Abnormal trabecular bone morphology (HP:0100671)	1.95375643
68	Methylmalonic aciduria (HP:0012120)	1.94290671
69	Trismus (HP:0000211)	1.92880151
70	Short nail (HP:0001799)	1.92874444
71	Hyperglycemia (HP:0003074)	1.92353088
72	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.91830381
73	Abnormal protein N-linked glycosylation (HP:0012347)	1.91830381
74	Abnormal protein glycosylation (HP:0012346)	1.91830381
75	Abnormal glycosylation (HP:0012345)	1.91830381
76	Hyperglycinuria (HP:0003108)	1.91774023
77	Proximal tubulopathy (HP:0000114)	1.90525334
78	Horseshoe kidney (HP:0000085)	1.89979981
79	Respiratory failure (HP:0002878)	1.89117054
80	Abnormality of serine family amino acid metabolism (HP:0010894)	1.88982638
81	Abnormality of glycine metabolism (HP:0010895)	1.88982638
82	Abnormal spermatogenesis (HP:0008669)	1.88956600
83	Microretrognathia (HP:0000308)	1.87776899
84	Abnormality of alanine metabolism (HP:0010916)	1.87580798
85	Hyperalaninemia (HP:0003348)	1.87580798
86	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.87580798
87	Testicular atrophy (HP:0000029)	1.87514735
88	Birth length less than 3rd percentile (HP:0003561)	1.87103413
89	Abnormality of cells of the erythroid lineage (HP:0012130)	1.87018577
90	Oligodactyly (HP:0012165)	1.87016119
91	Insulin-resistant diabetes mellitus (HP:0000831)	1.86505753
92	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.84459496
93	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.84459496
94	Abnormal umbilical cord blood vessels (HP:0011403)	1.83849116
95	Single umbilical artery (HP:0001195)	1.83849116
96	Abnormality of the fetal cardiovascular system (HP:0010948)	1.83849116
97	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.83736348
98	Congenital ichthyosiform erythroderma (HP:0007431)	1.83435580
99	Late onset (HP:0003584)	1.81624834
100	Facial hemangioma (HP:0000329)	1.81160819

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.09702376
2	VRK2	3.12404929
3	RPS6KB2	3.04955235
4	PBK	3.00876368
5	NME2	2.90879224
6	EIF2AK1	2.90577493
7	STK16	2.86243119
8	NEK1	2.81354720
9	PDK2	2.71432325
10	MST4	2.65043819
11	ZAK	2.60105226
12	STK39	2.37099051
13	CDC7	2.19006473
14	PASK	2.16132972
15	MAP3K9	2.06399131
16	MST1R	2.02810310
17	PIK3CA	1.84334212
18	OXSR1	1.84275939
19	LIMK1	1.68365046
20	SRPK1	1.66122564
21	MAP3K12	1.62746263
22	STK38L	1.61851480
23	PAK4	1.61585619
24	PLK1	1.54841436
25	SCYL2	1.50836144
26	BCKDK	1.47992391
27	BUB1	1.47887439
28	TESK2	1.45502575
29	PRKCI	1.44820235
30	TTK	1.38841413
31	WNK4	1.35562257
32	PNCK	1.33193662
33	VRK1	1.24672903
34	NME1	1.24506059
35	TESK1	1.22095516
36	AURKB	1.21032918
37	TLK1	1.20600349
38	EIF2AK3	1.16683782
39	AURKA	1.15289339
40	ILK	1.12267455
41	SIK1	1.09250648
42	MAP2K2	1.06462267
43	WEE1	1.05553189
44	IRAK3	1.04812016
45	TSSK6	1.04399725
46	CHEK2	0.93018321
47	CAMK2G	0.91473196
48	MET	0.90617973
49	CDK7	0.90567654
50	DAPK3	0.84373704
51	MAPKAPK3	0.81826534
52	ABL2	0.81670436
53	CDK19	0.79818660
54	PLK3	0.79548847
55	AKT2	0.74971240
56	ATR	0.74134064
57	PKN2	0.73116433
58	CHEK1	0.72729035
59	ERBB4	0.71218673
60	CAMK2D	0.70755054
61	MAP3K8	0.69696261
62	SMG1	0.69195016
63	DAPK1	0.68766606
64	MYLK	0.68297341
65	CAMK2B	0.66870548
66	PLK2	0.65005902
67	BRSK1	0.64238317
68	TRIB3	0.63434528
69	LRRK2	0.62805873
70	PLK4	0.60855519
71	GRK1	0.59167576
72	CSNK1E	0.53770903
73	PTK6	0.53064713
74	NEK6	0.50920301
75	MAP3K11	0.50185061
76	PHKG2	0.49697422
77	PHKG1	0.49697422
78	STK10	0.49509561
79	MAP3K3	0.49364767
80	PRKG2	0.48366626
81	CSNK2A2	0.48365845
82	MAP2K7	0.48236831
83	BRAF	0.45344553
84	PTK2	0.44567500
85	CSNK2A1	0.44432745
86	RPS6KA4	0.43675477
87	LMTK2	0.43667161
88	EIF2AK2	0.42376916
89	MAP3K2	0.41571429
90	CDK8	0.39072352
91	RPS6KB1	0.38230206
92	ATM	0.37868767
93	STK4	0.37844958
94	PAK1	0.36303639
95	TAF1	0.31678221
96	CDK9	0.31493192
97	PRKCG	0.31014088
98	MELK	0.30967669
99	RPS6KA5	0.29425401
100	KDR	0.27646112

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.87824825
2	Proteasome_Homo sapiens_hsa03050	3.85077049
3	DNA replication_Homo sapiens_hsa03030	3.01697534
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.83868847
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.74417898
6	Mismatch repair_Homo sapiens_hsa03430	2.26886907
7	Homologous recombination_Homo sapiens_hsa03440	2.18166036
8	Collecting duct acid secretion_Homo sapiens_hsa04966	2.14213637
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.10925997
10	Parkinsons disease_Homo sapiens_hsa05012	2.09385770
11	Sulfur relay system_Homo sapiens_hsa04122	1.93662872
12	RNA polymerase_Homo sapiens_hsa03020	1.92058210
13	Pyrimidine metabolism_Homo sapiens_hsa00240	1.91524489
14	Nucleotide excision repair_Homo sapiens_hsa03420	1.86588155
15	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.84932836
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.82301953
17	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.78550251
18	RNA transport_Homo sapiens_hsa03013	1.76768560
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.76443814
20	Huntingtons disease_Homo sapiens_hsa05016	1.72779843
21	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.71668068
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.69024228
23	Base excision repair_Homo sapiens_hsa03410	1.66757348
24	Folate biosynthesis_Homo sapiens_hsa00790	1.56885663
25	Spliceosome_Homo sapiens_hsa03040	1.52862727
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48497405
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.44751042
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.40520548
29	Vibrio cholerae infection_Homo sapiens_hsa05110	1.40176019
30	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.35981479
31	One carbon pool by folate_Homo sapiens_hsa00670	1.32090274
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27527093
33	Basal transcription factors_Homo sapiens_hsa03022	1.25934282
34	Fatty acid elongation_Homo sapiens_hsa00062	1.25164955
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.21678729
36	Glutathione metabolism_Homo sapiens_hsa00480	1.20129812
37	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.19482255
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.18123922
39	Protein export_Homo sapiens_hsa03060	1.17645754
40	Carbon metabolism_Homo sapiens_hsa01200	1.15705779
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.15040679
42	Alzheimers disease_Homo sapiens_hsa05010	1.13413204
43	Purine metabolism_Homo sapiens_hsa00230	1.13188865
44	Sulfur metabolism_Homo sapiens_hsa00920	1.06469441
45	Pyruvate metabolism_Homo sapiens_hsa00620	1.05905982
46	Pentose phosphate pathway_Homo sapiens_hsa00030	1.01586326
47	RNA degradation_Homo sapiens_hsa03018	1.00534199
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99811983
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.95925746
50	Galactose metabolism_Homo sapiens_hsa00052	0.93193961
51	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.92789432
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91685064
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91384927
54	Phenylalanine metabolism_Homo sapiens_hsa00360	0.87784083
55	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.87056621
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.86676099
57	Cell cycle_Homo sapiens_hsa04110	0.84422057
58	Propanoate metabolism_Homo sapiens_hsa00640	0.84147561
59	Metabolic pathways_Homo sapiens_hsa01100	0.83344767
60	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.83123947
61	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.81645444
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80807222
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78053041
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.77946643
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.77553906
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76701130
67	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.69672874
68	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.66596810
69	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.66154184
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61529606
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60853009
72	Peroxisome_Homo sapiens_hsa04146	0.59612213
73	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.59009915
74	mRNA surveillance pathway_Homo sapiens_hsa03015	0.58472909
75	p53 signaling pathway_Homo sapiens_hsa04115	0.56576520
76	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56010301
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53369464
78	Retinol metabolism_Homo sapiens_hsa00830	0.51872624
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49753802
80	Oocyte meiosis_Homo sapiens_hsa04114	0.47497651
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.46560852
82	Tight junction_Homo sapiens_hsa04530	0.46122336
83	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.46094812
84	Fatty acid degradation_Homo sapiens_hsa00071	0.46082485
85	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.45311844
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43826113
87	Butanoate metabolism_Homo sapiens_hsa00650	0.42929970
88	Tyrosine metabolism_Homo sapiens_hsa00350	0.41102693
89	Thyroid cancer_Homo sapiens_hsa05216	0.40028693
90	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.39695039
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.38934396
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.38380803
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.36372901
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.36089118
95	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.35228646
96	Hippo signaling pathway_Homo sapiens_hsa04390	0.34908646
97	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.30998716
98	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.30595546
99	Tryptophan metabolism_Homo sapiens_hsa00380	0.26156075
100	Alcoholism_Homo sapiens_hsa05034	0.25937164

KRT18P28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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