ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	7.39692115
2	regulation of mitochondrial translation (GO:0070129)	5.35989149
3	regulation of cellular amino acid metabolic process (GO:0006521)	5.31154927
4	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	5.11304104
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.07091589
6	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	4.87195355
7	chaperone-mediated protein transport (GO:0072321)	4.79903391
8	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	4.72018001
9	protein maturation by protein folding (GO:0022417)	4.66552613
10	respiratory chain complex IV assembly (GO:0008535)	4.63285229
11	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	4.63101352
12	negative regulation of ligase activity (GO:0051352)	4.60643545
13	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	4.60643545
14	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	4.59959211
15	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	4.59959211
16	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	4.54468753
17	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	4.54468753
18	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	4.54468753
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.40346877
20	signal transduction involved in DNA integrity checkpoint (GO:0072401)	4.39599773
21	signal transduction involved in DNA damage checkpoint (GO:0072422)	4.39599773
22	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	4.38380097
23	signal transduction involved in cell cycle checkpoint (GO:0072395)	4.30587172
24	cytochrome complex assembly (GO:0017004)	4.15652996
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.08637239
26	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	4.08497372
27	regulation of cellular amine metabolic process (GO:0033238)	4.07009698
28	protein complex biogenesis (GO:0070271)	3.98092663
29	respiratory electron transport chain (GO:0022904)	3.93768670
30	positive regulation of ligase activity (GO:0051351)	3.90447380
31	electron transport chain (GO:0022900)	3.87269326
32	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.77572434
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.70269057
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.63675354
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.63675354
36	NADH dehydrogenase complex assembly (GO:0010257)	3.63675354
37	positive regulation of cell cycle arrest (GO:0071158)	3.54292908
38	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	3.49880495
39	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.46884522
40	ribosome assembly (GO:0042255)	3.45846905
41	protein targeting to mitochondrion (GO:0006626)	3.45189456
42	regulation of ubiquitin-protein transferase activity (GO:0051438)	3.45045623
43	mannosylation (GO:0097502)	3.44623956
44	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.44591479
45	water-soluble vitamin biosynthetic process (GO:0042364)	3.42832345
46	ATP synthesis coupled proton transport (GO:0015986)	3.41166617
47	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.41166617
48	rRNA modification (GO:0000154)	3.41052363
49	regulation of ligase activity (GO:0051340)	3.32659730
50	regulation of oxidative phosphorylation (GO:0002082)	3.32507499
51	nucleotide-sugar biosynthetic process (GO:0009226)	3.32223206
52	negative regulation of protein ubiquitination (GO:0031397)	3.24422266
53	establishment of protein localization to mitochondrion (GO:0072655)	3.23882444
54	xenobiotic catabolic process (GO:0042178)	3.23354776
55	positive regulation of actin filament depolymerization (GO:0030836)	3.20293211
56	protein localization to mitochondrion (GO:0070585)	3.18379864
57	protein autoprocessing (GO:0016540)	3.17672936
58	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.12467709
59	glutathione derivative biosynthetic process (GO:1901687)	3.11547980
60	glutathione derivative metabolic process (GO:1901685)	3.11547980
61	pseudouridine synthesis (GO:0001522)	3.10578880
62	GDP-mannose metabolic process (GO:0019673)	3.07559618
63	regulation of cellular respiration (GO:0043457)	3.07091450
64	establishment of integrated proviral latency (GO:0075713)	3.06646139
65	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.06431644
66	negative regulation of protein modification by small protein conjugation or removal (GO:1903321)	3.05069014
67	ribosomal large subunit biogenesis (GO:0042273)	3.03893220
68	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.02063299
69	prostaglandin biosynthetic process (GO:0001516)	3.01203439
70	prostanoid biosynthetic process (GO:0046457)	3.01203439
71	regulation of cell cycle arrest (GO:0071156)	3.00439657
72	signal transduction in response to DNA damage (GO:0042770)	3.00190173
73	cobalamin metabolic process (GO:0009235)	2.98147022
74	establishment of viral latency (GO:0019043)	2.97685446
75	protein heterotetramerization (GO:0051290)	2.95858989
76	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.91250401
77	artery smooth muscle contraction (GO:0014824)	2.89168794
78	peptidyl-histidine modification (GO:0018202)	2.88350362
79	pteridine-containing compound biosynthetic process (GO:0042559)	2.87679592
80	nucleoside transmembrane transport (GO:1901642)	2.83944291
81	GTP biosynthetic process (GO:0006183)	2.81258939
82	hydrogen ion transmembrane transport (GO:1902600)	2.80617290
83	termination of RNA polymerase III transcription (GO:0006386)	2.79301787
84	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.79301787
85	regulation of metalloenzyme activity (GO:0048552)	2.77110866
86	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.75135849
87	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.75135849
88	negative regulation of cell cycle G1/S phase transition (GO:1902807)	2.70950973
89	negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	2.70950973
90	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.68754633
91	L-phenylalanine metabolic process (GO:0006558)	2.68754633
92	DNA damage response, detection of DNA damage (GO:0042769)	2.68620663
93	protein-cofactor linkage (GO:0018065)	2.68579834
94	DNA deamination (GO:0045006)	2.68453386
95	ATP hydrolysis coupled proton transport (GO:0015991)	2.66588781
96	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.66588781
97	regulation of phospholipase A2 activity (GO:0032429)	2.66228418
98	cell cycle G1/S phase transition (GO:0044843)	2.65007436
99	G1/S transition of mitotic cell cycle (GO:0000082)	2.65007436
100	intracellular protein transmembrane import (GO:0044743)	2.64836126

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.35507734
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.65117651
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.08117317
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.82310220
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.68371932
6	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.48744593
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.19201145
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.05116325
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.01492579
10	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.88393256
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.75835939
12	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.71887561
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.52896558
14	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.52523930
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.49919467
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44077002
17	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.37065429
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.33622456
19	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.32595954
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.30112216
21	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.29869388
22	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.27586556
23	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.16978210
24	DCP1A_22483619_ChIP-Seq_HELA_Human	2.14849153
25	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.12869156
26	ELK1_19687146_ChIP-ChIP_HELA_Human	2.08524266
27	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.99127517
28	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.95827429
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.95624770
30	GABP_19822575_ChIP-Seq_HepG2_Human	1.90878986
31	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.76497248
32	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.75628588
33	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.69527769
34	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.68492007
35	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.64731319
36	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.62191795
37	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.60858508
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.60521638
39	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.58441128
40	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.57106623
41	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.55387172
42	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.50690392
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.50476175
44	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.49358394
45	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.48977780
46	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.45313082
47	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.43765915
48	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.41495604
49	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.40645296
50	ZNF263_19887448_ChIP-Seq_K562_Human	1.40177360
51	GATA4_25053715_ChIP-Seq_YYC3_Human	1.39158371
52	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.34426595
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.30382057
54	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.29971494
55	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.27972650
56	ELF5_23300383_ChIP-Seq_T47D_Human	1.27117777
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.23791784
58	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.23627279
59	EOMES_21245162_ChIP-Seq_HESCs_Human	1.20339932
60	AR_21909140_ChIP-Seq_LNCAP_Human	1.17612520
61	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.17543802
62	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.17346309
63	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.15109837
64	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.14351136
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13064717
66	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.12553555
67	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.10499970
68	KDM5A_27292631_Chip-Seq_BREAST_Human	1.10323896
69	XRN2_22483619_ChIP-Seq_HELA_Human	1.08528026
70	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.07192259
71	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06262632
72	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06109463
73	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.04175759
74	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.02290524
75	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.99260767
76	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.97204578
77	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.96505792
78	GATA6_25053715_ChIP-Seq_YYC3_Human	0.94916123
79	AR_20517297_ChIP-Seq_VCAP_Human	0.94286769
80	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.92444740
81	SOX2_20726797_ChIP-Seq_SW620_Human	0.91918897
82	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.91183417
83	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.91055740
84	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.90110888
85	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.89649462
86	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.88829420
87	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.88784341
88	TFEB_21752829_ChIP-Seq_HELA_Human	0.88315111
89	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.86883646
90	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.86722704
91	ATF3_27146783_Chip-Seq_COLON_Human	0.85788452
92	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.83988440
93	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.83940576
94	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.83380971
95	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.82375491
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.82083931
97	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.81453509
98	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.79537869
99	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	0.79537869
100	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.78614581

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.56369747
2	MP0000516_abnormal_urinary_system	3.24475822
3	MP0005367_renal/urinary_system_phenotyp	3.24475822
4	MP0001666_abnormal_nutrient_absorption	2.92337480
5	MP0003693_abnormal_embryo_hatching	2.82720447
6	MP0009697_abnormal_copulation	2.71009686
7	MP0003786_premature_aging	2.69082403
8	MP0005670_abnormal_white_adipose	2.66951763
9	MP0000537_abnormal_urethra_morphology	2.58079453
10	MP0003186_abnormal_redox_activity	2.49315148
11	MP0005083_abnormal_biliary_tract	2.28557585
12	MP0005451_abnormal_body_composition	2.25274225
13	MP0004019_abnormal_vitamin_homeostasis	2.25222254
14	MP0008872_abnormal_physiological_respon	2.24306487
15	MP0008875_abnormal_xenobiotic_pharmacok	2.22891894
16	MP0003718_maternal_effect	2.18110833
17	MP0006035_abnormal_mitochondrial_morpho	2.17611869
18	MP0004147_increased_porphyrin_level	2.16004126
19	MP0010030_abnormal_orbit_morphology	2.13538552
20	MP0003315_abnormal_perineum_morphology	2.13082602
21	MP0004957_abnormal_blastocyst_morpholog	2.09352049
22	MP0009780_abnormal_chondrocyte_physiolo	2.06582436
23	MP0005365_abnormal_bile_salt	1.99522785
24	MP0003878_abnormal_ear_physiology	1.97116920
25	MP0005377_hearing/vestibular/ear_phenot	1.97116920
26	MP0006292_abnormal_olfactory_placode	1.91393930
27	MP0006036_abnormal_mitochondrial_physio	1.86307851
28	MP0001764_abnormal_homeostasis	1.80260284
29	MP0003123_paternal_imprinting	1.75217511
30	MP0005360_urolithiasis	1.67826715
31	MP0005332_abnormal_amino_acid	1.67808399
32	MP0008058_abnormal_DNA_repair	1.63502308
33	MP0006054_spinal_hemorrhage	1.62227649
34	MP0005085_abnormal_gallbladder_physiolo	1.59770716
35	MP0002837_dystrophic_cardiac_calcinosis	1.49212216
36	MP0000358_abnormal_cell_content/	1.48653816
37	MP0005084_abnormal_gallbladder_morpholo	1.48621693
38	MP0005646_abnormal_pituitary_gland	1.47822872
39	MP0003950_abnormal_plasma_membrane	1.46335181
40	MP0010234_abnormal_vibrissa_follicle	1.41447137
41	MP0010386_abnormal_urinary_bladder	1.40254475
42	MP0003195_calcinosis	1.39177209
43	MP0001756_abnormal_urination	1.38322112
44	MP0003191_abnormal_cellular_cholesterol	1.30808134
45	MP0004264_abnormal_extraembryonic_tissu	1.28331373
46	MP0005636_abnormal_mineral_homeostasis	1.27145851
47	MP0008932_abnormal_embryonic_tissue	1.26454130
48	MP0004233_abnormal_muscle_weight	1.24815793
49	MP0008995_early_reproductive_senescence	1.23810182
50	MP0000647_abnormal_sebaceous_gland	1.21309576
51	MP0000538_abnormal_urinary_bladder	1.16369008
52	MP0003077_abnormal_cell_cycle	1.09819061
53	MP0002796_impaired_skin_barrier	1.08024328
54	MP0001293_anophthalmia	1.07257090
55	MP0005410_abnormal_fertilization	1.07126381
56	MP0000372_irregular_coat_pigmentation	1.06904015
57	MP0005330_cardiomyopathy	1.06060793
58	MP0000749_muscle_degeneration	1.05405707
59	MP0002938_white_spotting	0.96469696
60	MP0001905_abnormal_dopamine_level	0.91987446
61	MP0005501_abnormal_skin_physiology	0.91243782
62	MP0002876_abnormal_thyroid_physiology	0.88538839
63	MP0001485_abnormal_pinna_reflex	0.88264690
64	MP0001542_abnormal_bone_strength	0.86729536
65	MP0003638_abnormal_response/metabolism_	0.86603723
66	MP0002254_reproductive_system_inflammat	0.85337453
67	MP0001881_abnormal_mammary_gland	0.84683508
68	MP0003890_abnormal_embryonic-extraembry	0.83733595
69	MP0008007_abnormal_cellular_replicative	0.83116407
70	MP0002736_abnormal_nociception_after	0.82608742
71	MP0008004_abnormal_stomach_pH	0.82509228
72	MP0001730_embryonic_growth_arrest	0.80840674
73	MP0003136_yellow_coat_color	0.79526340
74	MP0002160_abnormal_reproductive_system	0.79272344
75	MP0010352_gastrointestinal_tract_polyps	0.79065450
76	MP0009643_abnormal_urine_homeostasis	0.78980996
77	MP0005395_other_phenotype	0.78542208
78	MP0004272_abnormal_basement_membrane	0.76347142
79	MP0000627_abnormal_mammary_gland	0.75329061
80	MP0010771_integument_phenotype	0.74030961
81	MP0000613_abnormal_salivary_gland	0.72080516
82	MP0001727_abnormal_embryo_implantation	0.72034525
83	MP0002060_abnormal_skin_morphology	0.71736617
84	MP0001697_abnormal_embryo_size	0.71341976
85	MP0005319_abnormal_enzyme/_coenzyme	0.70480503
86	MP0002102_abnormal_ear_morphology	0.70083236
87	MP0001529_abnormal_vocalization	0.69963437
88	MP0010094_abnormal_chromosome_stability	0.69713271
89	MP0002210_abnormal_sex_determination	0.69367371
90	MP0010678_abnormal_skin_adnexa	0.68065274
91	MP0000427_abnormal_hair_cycle	0.67611129
92	MP0003936_abnormal_reproductive_system	0.66845437
93	MP0001929_abnormal_gametogenesis	0.66305072
94	MP0005645_abnormal_hypothalamus_physiol	0.65504058
95	MP0001145_abnormal_male_reproductive	0.65341163
96	MP0004142_abnormal_muscle_tone	0.65171918
97	MP0005584_abnormal_enzyme/coenzyme_acti	0.63809969
98	MP0000653_abnormal_sex_gland	0.62669521
99	MP0003938_abnormal_ear_development	0.59957874
100	MP0005266_abnormal_metabolism	0.59834366

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.13491777
2	Abnormal mitochondria in muscle tissue (HP:0008316)	5.03225884
3	Acute encephalopathy (HP:0006846)	4.59504131
4	Mitochondrial inheritance (HP:0001427)	4.59211195
5	Increased CSF lactate (HP:0002490)	4.27140390
6	Hepatocellular necrosis (HP:0001404)	4.23479806
7	Progressive macrocephaly (HP:0004481)	4.23202812
8	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.10908381
9	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.10908381
10	Hepatic necrosis (HP:0002605)	3.87324871
11	Hypokinesia (HP:0002375)	3.82320811
12	Type I transferrin isoform profile (HP:0003642)	3.74498058
13	Reduced antithrombin III activity (HP:0001976)	3.49347551
14	Abnormal protein glycosylation (HP:0012346)	3.30561878
15	Abnormal glycosylation (HP:0012345)	3.30561878
16	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.30561878
17	Abnormal protein N-linked glycosylation (HP:0012347)	3.30561878
18	Cerebral edema (HP:0002181)	3.27639358
19	Adrenal hypoplasia (HP:0000835)	3.22866532
20	Lactic acidosis (HP:0003128)	3.11766662
21	Increased serum lactate (HP:0002151)	3.07975569
22	Rough bone trabeculation (HP:0100670)	2.99915168
23	Respiratory failure (HP:0002878)	2.90203553
24	Increased intramyocellular lipid droplets (HP:0012240)	2.83132991
25	Sparse eyelashes (HP:0000653)	2.82873618
26	Lethargy (HP:0001254)	2.80914556
27	Increased hepatocellular lipid droplets (HP:0006565)	2.78051148
28	Lipid accumulation in hepatocytes (HP:0006561)	2.76876074
29	Delayed CNS myelination (HP:0002188)	2.74807334
30	Palpitations (HP:0001962)	2.69422735
31	Methylmalonic aciduria (HP:0012120)	2.65532159
32	Exercise intolerance (HP:0003546)	2.64900060
33	Increased serum pyruvate (HP:0003542)	2.54755407
34	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.49459594
35	Increased muscle lipid content (HP:0009058)	2.44944987
36	Oral leukoplakia (HP:0002745)	2.44721257
37	CNS demyelination (HP:0007305)	2.43064863
38	Nausea (HP:0002018)	2.42608305
39	Renal Fanconi syndrome (HP:0001994)	2.40701022
40	Leukodystrophy (HP:0002415)	2.40580374
41	Congenital ichthyosiform erythroderma (HP:0007431)	2.40282919
42	Abnormal trabecular bone morphology (HP:0100671)	2.40010111
43	Right ventricular cardiomyopathy (HP:0011663)	2.38048849
44	Abnormality of glycolysis (HP:0004366)	2.36623726
45	Optic disc pallor (HP:0000543)	2.33912146
46	Proximal tubulopathy (HP:0000114)	2.30401178
47	Methylmalonic acidemia (HP:0002912)	2.26382141
48	Testicular atrophy (HP:0000029)	2.25873118
49	X-linked dominant inheritance (HP:0001423)	2.24452765
50	Abnormality of alanine metabolism (HP:0010916)	2.17037031
51	Hyperalaninemia (HP:0003348)	2.17037031
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.17037031
53	Glycosuria (HP:0003076)	2.16883926
54	Abnormality of urine glucose concentration (HP:0011016)	2.16883926
55	Stenosis of the external auditory canal (HP:0000402)	2.16453171
56	Parakeratosis (HP:0001036)	2.15998383
57	Generalized aminoaciduria (HP:0002909)	2.12853685
58	Micronodular cirrhosis (HP:0001413)	2.11436601
59	Amniotic constriction ring (HP:0009775)	2.09601415
60	Abnormality of placental membranes (HP:0011409)	2.09601415
61	Cerebral palsy (HP:0100021)	2.08677454
62	Respiratory difficulties (HP:0002880)	2.07769616
63	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.07280094
64	Vascular calcification (HP:0004934)	2.05623022
65	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.03098855
66	Short 1st metacarpal (HP:0010034)	2.03098855
67	Severe visual impairment (HP:0001141)	2.02948088
68	Abnormality of serum amino acid levels (HP:0003112)	2.00076207
69	Abnormality of magnesium homeostasis (HP:0004921)	1.99612751
70	Diminished movement (HP:0002374)	1.99316160
71	3-Methylglutaconic aciduria (HP:0003535)	1.98653189
72	Abnormal tarsal ossification (HP:0008369)	1.97952466
73	Steatorrhea (HP:0002570)	1.97853673
74	Abnormality of renal resorption (HP:0011038)	1.96315891
75	Reduced subcutaneous adipose tissue (HP:0003758)	1.95827881
76	Septate vagina (HP:0001153)	1.95099903
77	Abnormality of methionine metabolism (HP:0010901)	1.93866621
78	Emotional lability (HP:0000712)	1.93778601
79	Congenital, generalized hypertrichosis (HP:0004540)	1.93270863
80	Renal tubular dysfunction (HP:0000124)	1.91362717
81	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.91249638
82	Abnormality of vitamin B metabolism (HP:0004340)	1.90082771
83	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.87096667
84	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.83750418
85	Abnormality of the 1st metacarpal (HP:0010009)	1.82109726
86	Cerebral hypomyelination (HP:0006808)	1.81615303
87	Upper limb muscle weakness (HP:0003484)	1.81436044
88	Hypoplastic pelvis (HP:0008839)	1.80178235
89	Delayed gross motor development (HP:0002194)	1.79061477
90	Abnormalities of placenta or umbilical cord (HP:0001194)	1.79044929
91	Blindness (HP:0000618)	1.77595622
92	Amelogenesis imperfecta (HP:0000705)	1.77149723
93	Hyperglycinemia (HP:0002154)	1.76078711
94	Secondary amenorrhea (HP:0000869)	1.74676186
95	Hypoglycemic coma (HP:0001325)	1.74524456
96	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.73419795
97	Dicarboxylic aciduria (HP:0003215)	1.73419795
98	Glucose intolerance (HP:0000833)	1.71339648
99	Abnormality of macular pigmentation (HP:0008002)	1.70196156
100	Cardiovascular calcification (HP:0011915)	1.68171656

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	3.98971096
2	NME2	3.79772396
3	MAP3K12	3.78389203
4	VRK2	3.60710413
5	EIF2AK1	3.46251603
6	PBK	3.02029574
7	TESK1	2.97211812
8	MST4	2.83637709
9	NME1	2.70982476
10	EIF2AK3	2.51536009
11	INSRR	2.35404020
12	BUB1	2.30772295
13	STK39	2.16764714
14	LIMK1	2.12928863
15	STK16	2.10083067
16	BCKDK	1.98752458
17	TESK2	1.95001276
18	OXSR1	1.88759310
19	MST1R	1.81176638
20	NEK1	1.79588806
21	PDK2	1.73588429
22	NUAK1	1.66576337
23	PAK4	1.57354183
24	WNK4	1.57264801
25	MYLK	1.57178602
26	RPS6KB2	1.54946139
27	SRPK1	1.45965162
28	FER	1.37207927
29	LATS1	1.25211566
30	DAPK1	1.25202590
31	MAP4K2	1.21698609
32	VRK1	1.20509186
33	MAPKAPK3	1.16515817
34	ZAK	1.09567343
35	ABL2	1.07536482
36	PRKCI	1.04875101
37	KDR	1.02366703
38	TRIM28	1.02094854
39	ERBB3	1.00985800
40	CSNK1G3	1.00670346
41	LMTK2	0.99867857
42	PHKG2	0.97579430
43	PHKG1	0.97579430
44	MAP2K7	0.88554089
45	PAK3	0.87550175
46	STK38L	0.86797023
47	GRK1	0.86507896
48	TLK1	0.84351374
49	CSNK1G1	0.82212087
50	ILK	0.82161059
51	MET	0.81069326
52	CSNK1A1L	0.80908922
53	ERBB4	0.79035418
54	DYRK2	0.78664776
55	ARAF	0.75308914
56	STK10	0.73190233
57	EIF2AK2	0.71138748
58	BMPR1B	0.70863858
59	PIM2	0.70787504
60	DAPK3	0.70698903
61	MAP3K3	0.69947525
62	PLK1	0.67666207
63	PAK1	0.65940609
64	CAMK2G	0.64127563
65	WEE1	0.63715255
66	AURKB	0.60993523
67	LRRK2	0.60853859
68	AURKA	0.59976655
69	SCYL2	0.57144023
70	CSNK1G2	0.56840675
71	PTK2	0.55916506
72	PRKCE	0.52929555
73	AKT2	0.52389853
74	PLK3	0.49571289
75	MAP3K8	0.48046860
76	CAMK2D	0.46088824
77	CASK	0.40473597
78	PRKG2	0.38711042
79	TNIK	0.36939008
80	FLT3	0.36794859
81	TSSK6	0.35956130
82	RPS6KA5	0.35709409
83	CSNK2A1	0.33258920
84	ADRBK2	0.33096666
85	MAP2K1	0.32998517
86	MELK	0.32095690
87	CSNK2A2	0.31884440
88	ACVR1B	0.30222858
89	FRK	0.27011374
90	MAP3K2	0.26039993
91	CAMK2B	0.25911162
92	PLK4	0.24300822
93	PRKCA	0.23248297
94	GRK5	0.22839773
95	BMX	0.22358975
96	CSNK1A1	0.22318391
97	FGFR1	0.21657784
98	ADRBK1	0.21232483
99	MAP2K2	0.20715228
100	BRSK1	0.19977261

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	6.00844617
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.56466162
3	Parkinsons disease_Homo sapiens_hsa05012	2.85823145
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.41165492
5	Sulfur metabolism_Homo sapiens_hsa00920	2.39975760
6	RNA polymerase_Homo sapiens_hsa03020	2.33999142
7	Fatty acid elongation_Homo sapiens_hsa00062	2.20157788
8	Huntingtons disease_Homo sapiens_hsa05016	2.14674870
9	Ribosome_Homo sapiens_hsa03010	2.12116685
10	Protein export_Homo sapiens_hsa03060	1.97378219
11	Glutathione metabolism_Homo sapiens_hsa00480	1.96946776
12	Folate biosynthesis_Homo sapiens_hsa00790	1.89620553
13	Alzheimers disease_Homo sapiens_hsa05010	1.88923656
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.74767291
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.70395457
16	DNA replication_Homo sapiens_hsa03030	1.69607315
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.69197843
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.68946228
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.63431916
20	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.59822378
21	Mismatch repair_Homo sapiens_hsa03430	1.53609508
22	Basal transcription factors_Homo sapiens_hsa03022	1.50968272
23	Homologous recombination_Homo sapiens_hsa03440	1.39016353
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.38580016
25	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.35708503
26	Vibrio cholerae infection_Homo sapiens_hsa05110	1.30729397
27	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.29092064
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.27911898
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.24847331
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24587902
31	Base excision repair_Homo sapiens_hsa03410	1.21185707
32	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.20525328
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.19706159
34	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.17051330
35	Fat digestion and absorption_Homo sapiens_hsa04975	1.16030149
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.15314232
37	One carbon pool by folate_Homo sapiens_hsa00670	1.12524145
38	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.11366177
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09595350
40	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.09259726
41	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.08761948
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.08603151
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.04234499
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.01600236
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01249011
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00028861
47	Galactose metabolism_Homo sapiens_hsa00052	0.99687199
48	Purine metabolism_Homo sapiens_hsa00230	0.99629497
49	Sulfur relay system_Homo sapiens_hsa04122	0.98959146
50	Metabolic pathways_Homo sapiens_hsa01100	0.98346644
51	Propanoate metabolism_Homo sapiens_hsa00640	0.97202024
52	Caffeine metabolism_Homo sapiens_hsa00232	0.97095442
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.97080166
54	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.96286250
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.95789859
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94220290
57	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.93959091
58	RNA degradation_Homo sapiens_hsa03018	0.91463317
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88822557
60	Peroxisome_Homo sapiens_hsa04146	0.85297508
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85164366
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.84250904
63	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.83037245
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.82207914
65	Carbon metabolism_Homo sapiens_hsa01200	0.81701351
66	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.81447971
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80395101
68	Pancreatic secretion_Homo sapiens_hsa04972	0.77404441
69	RNA transport_Homo sapiens_hsa03013	0.77168057
70	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.76895643
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76053769
72	Butanoate metabolism_Homo sapiens_hsa00650	0.74349646
73	Pentose phosphate pathway_Homo sapiens_hsa00030	0.72284985
74	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.70573524
75	Spliceosome_Homo sapiens_hsa03040	0.69225240
76	Mineral absorption_Homo sapiens_hsa04978	0.69208378
77	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.68114127
78	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.67849736
79	Retinol metabolism_Homo sapiens_hsa00830	0.67261763
80	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.65776220
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.65276257
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63506694
83	Protein digestion and absorption_Homo sapiens_hsa04974	0.61489609
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.56192901
85	Tryptophan metabolism_Homo sapiens_hsa00380	0.55728261
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.55284619
87	Fanconi anemia pathway_Homo sapiens_hsa03460	0.54144618
88	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.52020781
89	Tyrosine metabolism_Homo sapiens_hsa00350	0.51840183
90	Non-homologous end-joining_Homo sapiens_hsa03450	0.48982020
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.48966399
92	Tight junction_Homo sapiens_hsa04530	0.44318247
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.43550904
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43090041
95	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.41622052
96	Phenylalanine metabolism_Homo sapiens_hsa00360	0.39326278
97	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35935158
98	Fatty acid degradation_Homo sapiens_hsa00071	0.34780851
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33194795
100	Phototransduction_Homo sapiens_hsa04744	0.33004937

KRT18P29

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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