KRT18P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1homocysteine metabolic process (GO:0050667)8.13509025
2folic acid-containing compound biosynthetic process (GO:0009396)7.09372805
3tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.66355051
4RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.66355051
5cysteine metabolic process (GO:0006534)6.13046307
6sulfur amino acid catabolic process (GO:0000098)6.08722037
7regulation of plasminogen activation (GO:0010755)6.06129921
8purine nucleotide salvage (GO:0032261)5.76324927
9pteridine-containing compound biosynthetic process (GO:0042559)5.63440824
10epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.40971111
11adenosine metabolic process (GO:0046085)5.11533121
12chaperone-mediated protein transport (GO:0072321)5.08508385
13mitochondrial RNA metabolic process (GO:0000959)4.98271963
14desmosome organization (GO:0002934)4.70310637
15L-serine metabolic process (GO:0006563)4.68126087
16pseudouridine synthesis (GO:0001522)4.64253354
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.62939420
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.62939420
19NADH dehydrogenase complex assembly (GO:0010257)4.62939420
20negative regulation of DNA biosynthetic process (GO:2000279)4.58161320
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.49695242
22CENP-A containing nucleosome assembly (GO:0034080)4.45285952
23proteasome assembly (GO:0043248)4.43831372
24viral transcription (GO:0019083)4.43404903
25rRNA modification (GO:0000154)4.41198728
26IMP biosynthetic process (GO:0006188)4.36570239
27ribosomal small subunit assembly (GO:0000028)4.33889426
28white fat cell differentiation (GO:0050872)4.32415798
29microtubule nucleation (GO:0007020)4.29757272
30ribosomal small subunit biogenesis (GO:0042274)4.26831389
31chromatin remodeling at centromere (GO:0031055)4.25838458
32serine family amino acid biosynthetic process (GO:0009070)4.25106021
33translational termination (GO:0006415)4.23802449
34inner mitochondrial membrane organization (GO:0007007)4.23581568
35establishment of protein localization to mitochondrial membrane (GO:0090151)4.12705977
36tetrahydrofolate metabolic process (GO:0046653)4.07844348
37rRNA methylation (GO:0031167)4.06567782
38maturation of SSU-rRNA (GO:0030490)3.99818606
39ribosomal large subunit biogenesis (GO:0042273)3.99771959
40ribosome biogenesis (GO:0042254)3.99525683
41ribonucleoprotein complex biogenesis (GO:0022613)3.98637189
42protein complex biogenesis (GO:0070271)3.97313943
43protein-cofactor linkage (GO:0018065)3.95703972
44folic acid-containing compound metabolic process (GO:0006760)3.91528776
45galactose catabolic process (GO:0019388)3.90321269
46inner ear receptor cell development (GO:0060119)3.89606112
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.89132201
48ATP synthesis coupled proton transport (GO:0015986)3.89132201
49nucleoside transmembrane transport (GO:1901642)3.87513784
50aminoglycoside antibiotic metabolic process (GO:0030647)3.87481859
51negative regulation of keratinocyte proliferation (GO:0010839)3.86844400
52cellular component biogenesis (GO:0044085)3.85348249
53mitochondrial respiratory chain complex assembly (GO:0033108)3.76072188
54alternative mRNA splicing, via spliceosome (GO:0000380)3.72529223
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67757628
56translational elongation (GO:0006414)3.67326010
57energy homeostasis (GO:0097009)3.65705780
58tRNA modification (GO:0006400)3.65589604
59nucleotide salvage (GO:0043173)3.64435553
60pteridine-containing compound metabolic process (GO:0042558)3.63174229
61regulation of mitochondrial translation (GO:0070129)3.60756911
62cotranslational protein targeting to membrane (GO:0006613)3.59801935
63protein targeting to mitochondrion (GO:0006626)3.59420858
64galactose metabolic process (GO:0006012)3.58815597
65protein targeting to ER (GO:0045047)3.56724358
66IMP metabolic process (GO:0046040)3.55840530
67negative regulation of telomerase activity (GO:0051974)3.51473387
68positive regulation of endothelial cell differentiation (GO:0045603)3.51171798
69tRNA processing (GO:0008033)3.48120700
70artery smooth muscle contraction (GO:0014824)3.44688639
71establishment of protein localization to mitochondrion (GO:0072655)3.44253191
72protein localization to mitochondrion (GO:0070585)3.43386798
73energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.41925319
74ATP hydrolysis coupled proton transport (GO:0015991)3.41925319
75guanosine-containing compound biosynthetic process (GO:1901070)3.41607368
76establishment of protein localization to endoplasmic reticulum (GO:0072599)3.41556378
77sulfur amino acid biosynthetic process (GO:0000097)3.39439345
78DNA replication-independent nucleosome organization (GO:0034724)3.38513299
79DNA replication-independent nucleosome assembly (GO:0006336)3.38513299
80protein localization to endoplasmic reticulum (GO:0070972)3.36923502
81regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.35482775
82histone exchange (GO:0043486)3.34523979
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29145780
84transcription from mitochondrial promoter (GO:0006390)3.28737993
85respiratory electron transport chain (GO:0022904)3.24814505
86translational initiation (GO:0006413)3.22440677
87viral life cycle (GO:0019058)3.21355985
88negative regulation of Ras GTPase activity (GO:0034261)3.21226595
89cellular protein complex disassembly (GO:0043624)3.20484370
90rRNA processing (GO:0006364)3.20057259
91polyamine biosynthetic process (GO:0006596)3.17822649
92electron transport chain (GO:0022900)3.17765620
93regulation of gonadotropin secretion (GO:0032276)3.15538827
94phosphatidylglycerol biosynthetic process (GO:0006655)3.14618572
95nucleoside transport (GO:0015858)3.07392324
96negative regulation of catenin import into nucleus (GO:0035414)3.06507745
97regulation of oxidative phosphorylation (GO:0002082)3.04740748
98serine family amino acid catabolic process (GO:0009071)3.04300387
99regulation of tight junction assembly (GO:2000810)3.03931631
100kinetochore assembly (GO:0051382)3.03175171

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.64538124
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.90701471
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.32202852
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.25593113
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.90904378
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.79344685
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.72420411
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.23268828
9E2F7_22180533_ChIP-Seq_HELA_Human3.14022560
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.05982096
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96414284
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86132427
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75513366
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65997348
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59883212
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53504638
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42213092
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37968849
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36004445
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30991719
21XRN2_22483619_ChIP-Seq_HELA_Human2.27337828
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.17314298
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11732522
24FOXP3_21729870_ChIP-Seq_TREG_Human2.11551504
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07057832
26E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95540953
27GABP_19822575_ChIP-Seq_HepG2_Human1.94289626
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.85538125
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80639711
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76835279
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73254937
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.69496147
33VDR_23849224_ChIP-Seq_CD4+_Human1.66989921
34DCP1A_22483619_ChIP-Seq_HELA_Human1.61758552
35ZNF263_19887448_ChIP-Seq_K562_Human1.61296020
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.60626466
37TTF2_22483619_ChIP-Seq_HELA_Human1.59340870
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55299045
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46878285
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.46566129
41ELK1_19687146_ChIP-ChIP_HELA_Human1.44616870
42AR_21909140_ChIP-Seq_LNCAP_Human1.42543769
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38981035
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33020982
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32961379
46SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.31582614
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25549912
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22906327
49TBX5_21415370_ChIP-Seq_HL-1_Mouse1.19280023
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18959241
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17244600
52KDM5A_27292631_Chip-Seq_BREAST_Human1.16654337
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13261319
54VDR_22108803_ChIP-Seq_LS180_Human1.11881973
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09216308
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.09083773
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08373292
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08004108
59CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04595550
60ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04404208
61TP53_22573176_ChIP-Seq_HFKS_Human1.02971948
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01661767
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01012262
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00325323
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96615719
66YY1_22570637_ChIP-Seq_MALME-3M_Human0.96217117
67KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90927585
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90595950
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88422854
70SOX2_22085726_ChIP-Seq_NPCs_Mouse0.88368404
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88264015
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87830766
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87772902
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86686321
75CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86459407
76TP63_19390658_ChIP-ChIP_HaCaT_Human0.86149410
77ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85291145
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84700932
79SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84378612
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82761557
81STAT1_20625510_ChIP-Seq_HELA_Human0.81513009
82SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80262703
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.79560148
84ZNF274_21170338_ChIP-Seq_K562_Hela0.77503342
85NCOR_22424771_ChIP-Seq_293T_Human0.77421662
86ERG_20517297_ChIP-Seq_VCAP_Human0.77200353
87TET1_21451524_ChIP-Seq_MESCs_Mouse0.73968403
88FOXP1_21924763_ChIP-Seq_HESCs_Human0.73691308
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72737957
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.72189646
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.71626355
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.70881962
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.70327728
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.70327728
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.70327728
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.70105525
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.69714759
98STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.68484569
99MYC_18940864_ChIP-ChIP_HL60_Human0.66605057
100P68_20966046_ChIP-Seq_HELA_Human0.66408966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.93700241
2MP0005360_urolithiasis4.66266681
3MP0005646_abnormal_pituitary_gland3.79340849
4MP0003806_abnormal_nucleotide_metabolis3.42995873
5MP0002938_white_spotting3.20173677
6MP0003183_abnormal_peptide_metabolism3.03850504
7MP0003705_abnormal_hypodermis_morpholog3.03625737
8MP0004147_increased_porphyrin_level2.86165548
9MP0008995_early_reproductive_senescence2.81667506
10MP0002736_abnormal_nociception_after2.62943217
11MP0003186_abnormal_redox_activity2.59622453
12MP0001661_extended_life_span2.36152123
13MP0009379_abnormal_foot_pigmentation2.32590759
14MP0000647_abnormal_sebaceous_gland2.24620774
15MP0006292_abnormal_olfactory_placode2.19024795
16MP0000013_abnormal_adipose_tissue2.15000148
17MP0004185_abnormal_adipocyte_glucose2.11333390
18MP0003693_abnormal_embryo_hatching2.11004117
19MP0005332_abnormal_amino_acid2.05840455
20MP0004885_abnormal_endolymph2.04726794
21MP0009053_abnormal_anal_canal1.96824601
22MP0005367_renal/urinary_system_phenotyp1.95176645
23MP0000516_abnormal_urinary_system1.95176645
24MP0008872_abnormal_physiological_respon1.82444712
25MP0002396_abnormal_hematopoietic_system1.82225185
26MP0002160_abnormal_reproductive_system1.81798248
27MP0005377_hearing/vestibular/ear_phenot1.75989216
28MP0003878_abnormal_ear_physiology1.75989216
29MP0001764_abnormal_homeostasis1.70261790
30MP0002837_dystrophic_cardiac_calcinosis1.65158976
31MP0003786_premature_aging1.59061886
32MP0004019_abnormal_vitamin_homeostasis1.54904400
33MP0000534_abnormal_ureter_morphology1.52312517
34MP0002735_abnormal_chemical_nociception1.47936170
35MP0004957_abnormal_blastocyst_morpholog1.44704384
36MP0003942_abnormal_urinary_system1.42601449
37MP0008058_abnormal_DNA_repair1.40881853
38MP0001968_abnormal_touch/_nociception1.35973541
39MP0003111_abnormal_nucleus_morphology1.33852524
40MP0003937_abnormal_limbs/digits/tail_de1.30998175
41MP0000678_abnormal_parathyroid_gland1.25035612
42MP0000631_abnormal_neuroendocrine_gland1.19843426
43MP0002095_abnormal_skin_pigmentation1.19299492
44MP0001293_anophthalmia1.15083046
45MP0005636_abnormal_mineral_homeostasis1.13455998
46MP0005085_abnormal_gallbladder_physiolo1.12402118
47MP0003567_abnormal_fetal_cardiomyocyte1.11279594
48MP0004133_heterotaxia1.10532438
49MP0005187_abnormal_penis_morphology1.09368119
50MP0004043_abnormal_pH_regulation1.08531754
51MP0002132_abnormal_respiratory_system1.06150503
52MP0000049_abnormal_middle_ear1.04423295
53MP0003880_abnormal_central_pattern1.03028615
54MP0003123_paternal_imprinting1.02272432
55MP0006036_abnormal_mitochondrial_physio1.00693297
56MP0001145_abnormal_male_reproductive0.97892527
57MP0002697_abnormal_eye_size0.97566285
58MP0002210_abnormal_sex_determination0.96665799
59MP0009697_abnormal_copulation0.96442313
60MP0003077_abnormal_cell_cycle0.94889738
61MP0005410_abnormal_fertilization0.93427102
62MP0005389_reproductive_system_phenotype0.93101440
63MP0006276_abnormal_autonomic_nervous0.93087304
64MP0000026_abnormal_inner_ear0.92612217
65MP0000653_abnormal_sex_gland0.90792160
66MP0000762_abnormal_tongue_morphology0.90092238
67MP0008932_abnormal_embryonic_tissue0.85889256
68MP0003283_abnormal_digestive_organ0.85715768
69MP0000750_abnormal_muscle_regeneration0.83228233
70MP0005551_abnormal_eye_electrophysiolog0.82648918
71MP0003718_maternal_effect0.81787017
72MP0009250_abnormal_appendicular_skeleto0.81497410
73MP0009643_abnormal_urine_homeostasis0.81495217
74MP0002234_abnormal_pharynx_morphology0.81438477
75MP0001270_distended_abdomen0.78147234
76MP0003315_abnormal_perineum_morphology0.77588234
77MP0010094_abnormal_chromosome_stability0.77394166
78MP0006035_abnormal_mitochondrial_morpho0.76661715
79MP0010030_abnormal_orbit_morphology0.74853881
80MP0004233_abnormal_muscle_weight0.74787889
81MP0005084_abnormal_gallbladder_morpholo0.74559164
82MP0003724_increased_susceptibility_to0.72100951
83MP0001666_abnormal_nutrient_absorption0.71873383
84MP0001756_abnormal_urination0.71315828
85MP0001944_abnormal_pancreas_morphology0.71163336
86MP0003890_abnormal_embryonic-extraembry0.70245895
87MP0001919_abnormal_reproductive_system0.69632914
88MP0001485_abnormal_pinna_reflex0.69092043
89MP0003698_abnormal_male_reproductive0.68506241
90MP0002277_abnormal_respiratory_mucosa0.68420148
91MP0002249_abnormal_larynx_morphology0.67420682
92MP0008875_abnormal_xenobiotic_pharmacok0.67101615
93MP0000003_abnormal_adipose_tissue0.65556323
94MP0005365_abnormal_bile_salt0.64754134
95MP0003936_abnormal_reproductive_system0.63653891
96MP0002138_abnormal_hepatobiliary_system0.62719513
97MP0003638_abnormal_response/metabolism_0.62213199
98MP0001963_abnormal_hearing_physiology0.61674135
99MP0002139_abnormal_hepatobiliary_system0.60619236
100MP0001929_abnormal_gametogenesis0.59529465

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)8.01633878
2Hyperalaninemia (HP:0003348)8.01633878
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)8.01633878
4Abnormal umbilical cord blood vessels (HP:0011403)5.53367088
5Single umbilical artery (HP:0001195)5.53367088
6Abnormality of the fetal cardiovascular system (HP:0010948)5.53367088
7Constricted visual fields (HP:0001133)5.07348090
8Congenital sensorineural hearing impairment (HP:0008527)4.29874567
9Esophageal varix (HP:0002040)4.26306168
10Abnormality of the umbilical cord (HP:0010881)4.01635778
11Abnormality of serum amino acid levels (HP:0003112)3.97877800
12Abnormality of homocysteine metabolism (HP:0010919)3.83114163
13Homocystinuria (HP:0002156)3.83114163
14Birth length less than 3rd percentile (HP:0003561)3.76186810
15Decreased electroretinogram (ERG) amplitude (HP:0000654)3.73048153
16Abnormality of the phalanges of the hallux (HP:0010057)3.47788705
17Generalized aminoaciduria (HP:0002909)3.46672289
18White forelock (HP:0002211)3.32055080
19Patchy hypopigmentation of hair (HP:0011365)3.24726032
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.06776427
21Increased serum pyruvate (HP:0003542)3.04698131
22Spontaneous hematomas (HP:0007420)2.99983702
23Acute necrotizing encephalopathy (HP:0006965)2.99843255
24Maternal diabetes (HP:0009800)2.99128432
25Nausea (HP:0002018)2.90778125
26Acute encephalopathy (HP:0006846)2.88526573
27Hyperglycinemia (HP:0002154)2.80168523
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78179317
29Reticulocytopenia (HP:0001896)2.71291884
30Abnormal mitochondria in muscle tissue (HP:0008316)2.70381325
31Anorexia (HP:0002039)2.63299828
32Abnormalities of placenta or umbilical cord (HP:0001194)2.62552764
33Abnormality of glycolysis (HP:0004366)2.58427842
34Myocardial infarction (HP:0001658)2.56790077
35Conjugated hyperbilirubinemia (HP:0002908)2.56176815
36Poor speech (HP:0002465)2.48216153
37Proximal tubulopathy (HP:0000114)2.46022530
38Increased serum lactate (HP:0002151)2.42743320
39Hypoplastic left heart (HP:0004383)2.42658410
40Macrocytic anemia (HP:0001972)2.37338991
41Conjunctival telangiectasia (HP:0000524)2.36874649
42Cavernous hemangioma (HP:0001048)2.35147637
43Progressive macrocephaly (HP:0004481)2.34122670
44Mitochondrial inheritance (HP:0001427)2.33772027
45Tetany (HP:0001281)2.32383057
46Lactic acidosis (HP:0003128)2.29948837
47Increased CSF lactate (HP:0002490)2.24035296
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22160928
49Cerebral edema (HP:0002181)2.21053957
50Reduced subcutaneous adipose tissue (HP:0003758)2.20725554
51Methylmalonic acidemia (HP:0002912)2.15624519
52Anencephaly (HP:0002323)2.09944957
53Hyperphosphaturia (HP:0003109)2.09213929
54Metabolic acidosis (HP:0001942)2.09093885
55Cortical visual impairment (HP:0100704)2.06727688
56Hepatic necrosis (HP:0002605)2.06353368
57Short middle phalanx of the 5th finger (HP:0004220)2.06305278
58Hypomagnesemia (HP:0002917)2.05892259
59Esophageal atresia (HP:0002032)2.03993036
60Chronic hepatic failure (HP:0100626)2.03822090
61Hypoalphalipoproteinemia (HP:0003233)2.03820105
62Occipital encephalocele (HP:0002085)1.98768058
63Paralysis (HP:0003470)1.98206450
64Hepatocellular necrosis (HP:0001404)1.98090509
65Stenosis of the external auditory canal (HP:0000402)1.97778556
66Lethargy (HP:0001254)1.97148002
67Pallor (HP:0000980)1.95061114
68Action tremor (HP:0002345)1.94109806
69Chorioretinal atrophy (HP:0000533)1.93241868
70Abnormal tarsal ossification (HP:0008369)1.86489360
71Hypoplastic heart (HP:0001961)1.86328898
723-Methylglutaconic aciduria (HP:0003535)1.85812723
73Abnormality of the distal phalanges of the toes (HP:0010182)1.85767166
74Decreased subcutaneous fat (HP:0001002)1.85158259
75Ectopic kidney (HP:0000086)1.84673191
76Megaloblastic anemia (HP:0001889)1.84221922
77Abnormality of the middle phalanges of the toes (HP:0010183)1.82980328
78Methylmalonic aciduria (HP:0012120)1.82934601
79Abnormality of the vasculature of the conjunctiva (HP:0008054)1.82443712
80Glycosuria (HP:0003076)1.82219253
81Abnormality of urine glucose concentration (HP:0011016)1.82219253
82Pendular nystagmus (HP:0012043)1.81008633
83Oligomenorrhea (HP:0000876)1.80490749
84Abnormality of magnesium homeostasis (HP:0004921)1.80079330
85Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79227348
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79227348
87Triphalangeal thumb (HP:0001199)1.78509532
88Abnormality of cochlea (HP:0000375)1.77052173
89Abnormality of cells of the erythroid lineage (HP:0012130)1.76356243
90Type I transferrin isoform profile (HP:0003642)1.76329967
91Abnormality of glycine metabolism (HP:0010895)1.74157090
92Abnormality of serine family amino acid metabolism (HP:0010894)1.74157090
93Broad distal phalanx of finger (HP:0009836)1.73804408
94Ileus (HP:0002595)1.73734953
95Insulin-resistant diabetes mellitus (HP:0000831)1.69828904
96Abnormal number of erythroid precursors (HP:0012131)1.69438330
97Exercise intolerance (HP:0003546)1.69221311
98Duplication of thumb phalanx (HP:0009942)1.67923160
99Bone marrow hypocellularity (HP:0005528)1.67302561
100Partial duplication of thumb phalanx (HP:0009944)1.63972133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.84948225
2MAP3K33.49021430
3RPS6KB23.33197458
4MAP2K32.78572114
5ACVR1B2.74305450
6CDC72.73319632
7WNK42.63411165
8CDK92.46995870
9TAF12.38923159
10BCKDK2.35309662
11NME22.33263439
12STK392.27193325
13NUAK12.22127071
14BUB12.21096395
15PDK22.16890535
16FGR2.03817621
17EPHB21.99832752
18OXSR11.95711974
19EPHA21.95015831
20PBK1.81967827
21MUSK1.79853488
22JAK31.51324461
23NTRK21.50779912
24NEK11.43881403
25VRK11.42034172
26AURKA1.39821676
27TLK11.35325938
28DYRK21.26669276
29NME11.20693537
30SGK2231.17138975
31SGK4941.17138975
32PAK41.16841258
33CCNB11.15747758
34MST41.14817174
35PRKCI1.14536721
36INSRR1.12796175
37GRK11.06742818
38TNIK1.03044183
39LMTK21.02426157
40ADRBK11.01088884
41CHEK21.01042703
42CDK190.98764220
43MAP4K20.96032555
44EIF2AK10.91223215
45CAMK10.90021343
46NTRK30.86790831
47SGK20.85837791
48TRIM280.85468149
49STK160.83469138
50ZAK0.82036811
51SMG10.81604965
52CSNK1A10.80853073
53MAP2K10.80792320
54CDK70.80285910
55SRPK10.78318200
56WNK30.76957943
57DAPK10.76535929
58PLK40.74734242
59NEK60.73071587
60MAP3K110.72716657
61DAPK30.72691456
62CAMK2G0.71789360
63ABL20.71692524
64PLK10.69672418
65ADRBK20.69156113
66CAMK2B0.68747939
67PLK30.64236775
68AKT20.62224108
69CAMK2D0.60235273
70AURKB0.60235121
71CSNK1G30.58340032
72PTK60.57478768
73GRK50.55598869
74PIK3CA0.54966209
75CSNK2A10.54950313
76BMPR1B0.50060581
77SGK30.49776720
78IRAK20.48856781
79TTK0.48552679
80BRSK10.46845266
81CSNK2A20.46522386
82RPS6KB10.45394935
83PRKCE0.43606500
84PHKG10.42799237
85PHKG20.42799237
86ATR0.42698046
87PRKCD0.42241625
88BRSK20.39244982
89PASK0.38703523
90CSNK1G20.37502601
91CSNK1G10.36972101
92PINK10.35664540
93MAP2K70.35149716
94MAPKAPK50.34594257
95ILK0.32415619
96PLK20.32324065
97CDK40.30869409
98KDR0.29382932
99IRAK30.28983163
100PRKCA0.27794071

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.06886867
2One carbon pool by folate_Homo sapiens_hsa006703.70862663
3Oxidative phosphorylation_Homo sapiens_hsa001903.61150245
4Collecting duct acid secretion_Homo sapiens_hsa049663.16440477
5Proteasome_Homo sapiens_hsa030502.91026802
6Sulfur relay system_Homo sapiens_hsa041222.73457389
7Parkinsons disease_Homo sapiens_hsa050122.53875255
8Sulfur metabolism_Homo sapiens_hsa009202.33067329
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27284068
10Arginine biosynthesis_Homo sapiens_hsa002202.16115845
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.14288524
12Selenocompound metabolism_Homo sapiens_hsa004502.14204954
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.03962869
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01110510
15Huntingtons disease_Homo sapiens_hsa050162.01001603
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.92961482
17RNA polymerase_Homo sapiens_hsa030201.71845770
18Alzheimers disease_Homo sapiens_hsa050101.68878670
19DNA replication_Homo sapiens_hsa030301.62737561
20Spliceosome_Homo sapiens_hsa030401.59472774
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57570947
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54743456
23Galactose metabolism_Homo sapiens_hsa000521.51022722
24Vibrio cholerae infection_Homo sapiens_hsa051101.47261565
25Base excision repair_Homo sapiens_hsa034101.41044779
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40618396
27Folate biosynthesis_Homo sapiens_hsa007901.40068233
28Biosynthesis of amino acids_Homo sapiens_hsa012301.36174434
29Vitamin digestion and absorption_Homo sapiens_hsa049771.35557984
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26237378
31Homologous recombination_Homo sapiens_hsa034401.24851677
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23633436
33RNA degradation_Homo sapiens_hsa030181.21960338
34RNA transport_Homo sapiens_hsa030131.20093096
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19849005
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18925134
37Basal transcription factors_Homo sapiens_hsa030221.18782415
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.16063181
39Glutathione metabolism_Homo sapiens_hsa004801.12169369
40Retinol metabolism_Homo sapiens_hsa008301.10831262
41Protein export_Homo sapiens_hsa030601.09182567
42Synaptic vesicle cycle_Homo sapiens_hsa047211.03833927
43Regulation of autophagy_Homo sapiens_hsa041401.03045104
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01701761
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01414611
46Pyrimidine metabolism_Homo sapiens_hsa002400.98269846
47Fat digestion and absorption_Homo sapiens_hsa049750.97308022
48Arginine and proline metabolism_Homo sapiens_hsa003300.95715141
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94745018
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94729778
51Nucleotide excision repair_Homo sapiens_hsa034200.93248756
52Metabolic pathways_Homo sapiens_hsa011000.92263375
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92194648
54Mismatch repair_Homo sapiens_hsa034300.90759346
55Nicotine addiction_Homo sapiens_hsa050330.84472675
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83537082
57Cardiac muscle contraction_Homo sapiens_hsa042600.82342735
58Chemical carcinogenesis_Homo sapiens_hsa052040.82208911
59Fanconi anemia pathway_Homo sapiens_hsa034600.77786217
60GABAergic synapse_Homo sapiens_hsa047270.77540648
61Morphine addiction_Homo sapiens_hsa050320.77374464
62Peroxisome_Homo sapiens_hsa041460.73637927
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73525911
64Purine metabolism_Homo sapiens_hsa002300.72818775
65Nitrogen metabolism_Homo sapiens_hsa009100.72402778
66Pyruvate metabolism_Homo sapiens_hsa006200.71271473
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.69191804
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66715532
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63303218
70Starch and sucrose metabolism_Homo sapiens_hsa005000.63187656
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.62865816
72Carbon metabolism_Homo sapiens_hsa012000.58194737
73Arachidonic acid metabolism_Homo sapiens_hsa005900.57873919
74mRNA surveillance pathway_Homo sapiens_hsa030150.57582478
75Ether lipid metabolism_Homo sapiens_hsa005650.57306121
76Linoleic acid metabolism_Homo sapiens_hsa005910.57291723
77Phenylalanine metabolism_Homo sapiens_hsa003600.57250996
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53108735
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52062139
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49689840
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49501760
82Tryptophan metabolism_Homo sapiens_hsa003800.49338815
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48859892
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48506558
85Fatty acid biosynthesis_Homo sapiens_hsa000610.48463964
86Olfactory transduction_Homo sapiens_hsa047400.48245442
87Tyrosine metabolism_Homo sapiens_hsa003500.46518424
88Butanoate metabolism_Homo sapiens_hsa006500.46111714
89Propanoate metabolism_Homo sapiens_hsa006400.45086660
90Non-homologous end-joining_Homo sapiens_hsa034500.42217502
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40764271
92Fatty acid degradation_Homo sapiens_hsa000710.40550921
93Rheumatoid arthritis_Homo sapiens_hsa053230.36953236
94Thyroid cancer_Homo sapiens_hsa052160.36619194
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36043367
96beta-Alanine metabolism_Homo sapiens_hsa004100.35305461
97Fatty acid elongation_Homo sapiens_hsa000620.32317954
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31435244
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30758695
100Serotonergic synapse_Homo sapiens_hsa047260.29394149

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