

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | homocysteine metabolic process (GO:0050667) | 8.13509025 |
| 2 | folic acid-containing compound biosynthetic process (GO:0009396) | 7.09372805 |
| 3 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 6.66355051 |
| 4 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 6.66355051 |
| 5 | cysteine metabolic process (GO:0006534) | 6.13046307 |
| 6 | sulfur amino acid catabolic process (GO:0000098) | 6.08722037 |
| 7 | regulation of plasminogen activation (GO:0010755) | 6.06129921 |
| 8 | purine nucleotide salvage (GO:0032261) | 5.76324927 |
| 9 | pteridine-containing compound biosynthetic process (GO:0042559) | 5.63440824 |
| 10 | epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198) | 5.40971111 |
| 11 | adenosine metabolic process (GO:0046085) | 5.11533121 |
| 12 | chaperone-mediated protein transport (GO:0072321) | 5.08508385 |
| 13 | mitochondrial RNA metabolic process (GO:0000959) | 4.98271963 |
| 14 | desmosome organization (GO:0002934) | 4.70310637 |
| 15 | L-serine metabolic process (GO:0006563) | 4.68126087 |
| 16 | pseudouridine synthesis (GO:0001522) | 4.64253354 |
| 17 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.62939420 |
| 18 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.62939420 |
| 19 | NADH dehydrogenase complex assembly (GO:0010257) | 4.62939420 |
| 20 | negative regulation of DNA biosynthetic process (GO:2000279) | 4.58161320 |
| 21 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.49695242 |
| 22 | CENP-A containing nucleosome assembly (GO:0034080) | 4.45285952 |
| 23 | proteasome assembly (GO:0043248) | 4.43831372 |
| 24 | viral transcription (GO:0019083) | 4.43404903 |
| 25 | rRNA modification (GO:0000154) | 4.41198728 |
| 26 | IMP biosynthetic process (GO:0006188) | 4.36570239 |
| 27 | ribosomal small subunit assembly (GO:0000028) | 4.33889426 |
| 28 | white fat cell differentiation (GO:0050872) | 4.32415798 |
| 29 | microtubule nucleation (GO:0007020) | 4.29757272 |
| 30 | ribosomal small subunit biogenesis (GO:0042274) | 4.26831389 |
| 31 | chromatin remodeling at centromere (GO:0031055) | 4.25838458 |
| 32 | serine family amino acid biosynthetic process (GO:0009070) | 4.25106021 |
| 33 | translational termination (GO:0006415) | 4.23802449 |
| 34 | inner mitochondrial membrane organization (GO:0007007) | 4.23581568 |
| 35 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.12705977 |
| 36 | tetrahydrofolate metabolic process (GO:0046653) | 4.07844348 |
| 37 | rRNA methylation (GO:0031167) | 4.06567782 |
| 38 | maturation of SSU-rRNA (GO:0030490) | 3.99818606 |
| 39 | ribosomal large subunit biogenesis (GO:0042273) | 3.99771959 |
| 40 | ribosome biogenesis (GO:0042254) | 3.99525683 |
| 41 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.98637189 |
| 42 | protein complex biogenesis (GO:0070271) | 3.97313943 |
| 43 | protein-cofactor linkage (GO:0018065) | 3.95703972 |
| 44 | folic acid-containing compound metabolic process (GO:0006760) | 3.91528776 |
| 45 | galactose catabolic process (GO:0019388) | 3.90321269 |
| 46 | inner ear receptor cell development (GO:0060119) | 3.89606112 |
| 47 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.89132201 |
| 48 | ATP synthesis coupled proton transport (GO:0015986) | 3.89132201 |
| 49 | nucleoside transmembrane transport (GO:1901642) | 3.87513784 |
| 50 | aminoglycoside antibiotic metabolic process (GO:0030647) | 3.87481859 |
| 51 | negative regulation of keratinocyte proliferation (GO:0010839) | 3.86844400 |
| 52 | cellular component biogenesis (GO:0044085) | 3.85348249 |
| 53 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.76072188 |
| 54 | alternative mRNA splicing, via spliceosome (GO:0000380) | 3.72529223 |
| 55 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.67757628 |
| 56 | translational elongation (GO:0006414) | 3.67326010 |
| 57 | energy homeostasis (GO:0097009) | 3.65705780 |
| 58 | tRNA modification (GO:0006400) | 3.65589604 |
| 59 | nucleotide salvage (GO:0043173) | 3.64435553 |
| 60 | pteridine-containing compound metabolic process (GO:0042558) | 3.63174229 |
| 61 | regulation of mitochondrial translation (GO:0070129) | 3.60756911 |
| 62 | cotranslational protein targeting to membrane (GO:0006613) | 3.59801935 |
| 63 | protein targeting to mitochondrion (GO:0006626) | 3.59420858 |
| 64 | galactose metabolic process (GO:0006012) | 3.58815597 |
| 65 | protein targeting to ER (GO:0045047) | 3.56724358 |
| 66 | IMP metabolic process (GO:0046040) | 3.55840530 |
| 67 | negative regulation of telomerase activity (GO:0051974) | 3.51473387 |
| 68 | positive regulation of endothelial cell differentiation (GO:0045603) | 3.51171798 |
| 69 | tRNA processing (GO:0008033) | 3.48120700 |
| 70 | artery smooth muscle contraction (GO:0014824) | 3.44688639 |
| 71 | establishment of protein localization to mitochondrion (GO:0072655) | 3.44253191 |
| 72 | protein localization to mitochondrion (GO:0070585) | 3.43386798 |
| 73 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.41925319 |
| 74 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.41925319 |
| 75 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.41607368 |
| 76 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.41556378 |
| 77 | sulfur amino acid biosynthetic process (GO:0000097) | 3.39439345 |
| 78 | DNA replication-independent nucleosome organization (GO:0034724) | 3.38513299 |
| 79 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.38513299 |
| 80 | protein localization to endoplasmic reticulum (GO:0070972) | 3.36923502 |
| 81 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 3.35482775 |
| 82 | histone exchange (GO:0043486) | 3.34523979 |
| 83 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.29145780 |
| 84 | transcription from mitochondrial promoter (GO:0006390) | 3.28737993 |
| 85 | respiratory electron transport chain (GO:0022904) | 3.24814505 |
| 86 | translational initiation (GO:0006413) | 3.22440677 |
| 87 | viral life cycle (GO:0019058) | 3.21355985 |
| 88 | negative regulation of Ras GTPase activity (GO:0034261) | 3.21226595 |
| 89 | cellular protein complex disassembly (GO:0043624) | 3.20484370 |
| 90 | rRNA processing (GO:0006364) | 3.20057259 |
| 91 | polyamine biosynthetic process (GO:0006596) | 3.17822649 |
| 92 | electron transport chain (GO:0022900) | 3.17765620 |
| 93 | regulation of gonadotropin secretion (GO:0032276) | 3.15538827 |
| 94 | phosphatidylglycerol biosynthetic process (GO:0006655) | 3.14618572 |
| 95 | nucleoside transport (GO:0015858) | 3.07392324 |
| 96 | negative regulation of catenin import into nucleus (GO:0035414) | 3.06507745 |
| 97 | regulation of oxidative phosphorylation (GO:0002082) | 3.04740748 |
| 98 | serine family amino acid catabolic process (GO:0009071) | 3.04300387 |
| 99 | regulation of tight junction assembly (GO:2000810) | 3.03931631 |
| 100 | kinetochore assembly (GO:0051382) | 3.03175171 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 8.64538124 |
| 2 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 4.90701471 |
| 3 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.32202852 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.25593113 |
| 5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.90904378 |
| 6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.79344685 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.72420411 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.23268828 |
| 9 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.14022560 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.05982096 |
| 11 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.96414284 |
| 12 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.86132427 |
| 13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.75513366 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.65997348 |
| 15 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.59883212 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.53504638 |
| 17 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.42213092 |
| 18 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.37968849 |
| 19 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.36004445 |
| 20 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.30991719 |
| 21 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.27337828 |
| 22 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.17314298 |
| 23 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.11732522 |
| 24 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.11551504 |
| 25 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.07057832 |
| 26 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.95540953 |
| 27 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.94289626 |
| 28 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.85538125 |
| 29 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.80639711 |
| 30 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.76835279 |
| 31 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.73254937 |
| 32 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.69496147 |
| 33 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.66989921 |
| 34 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.61758552 |
| 35 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.61296020 |
| 36 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.60626466 |
| 37 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.59340870 |
| 38 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.55299045 |
| 39 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.46878285 |
| 40 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.46566129 |
| 41 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.44616870 |
| 42 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.42543769 |
| 43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.38981035 |
| 44 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.33020982 |
| 45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.32961379 |
| 46 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.31582614 |
| 47 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.25549912 |
| 48 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.22906327 |
| 49 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.19280023 |
| 50 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.18959241 |
| 51 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.17244600 |
| 52 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.16654337 |
| 53 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.13261319 |
| 54 | VDR_22108803_ChIP-Seq_LS180_Human | 1.11881973 |
| 55 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.09216308 |
| 56 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.09083773 |
| 57 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.08373292 |
| 58 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.08004108 |
| 59 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.04595550 |
| 60 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.04404208 |
| 61 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.02971948 |
| 62 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.01661767 |
| 63 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.01012262 |
| 64 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.00325323 |
| 65 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.96615719 |
| 66 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.96217117 |
| 67 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.90927585 |
| 68 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.90595950 |
| 69 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.88422854 |
| 70 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 0.88368404 |
| 71 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.88264015 |
| 72 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.87830766 |
| 73 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.87772902 |
| 74 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.86686321 |
| 75 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.86459407 |
| 76 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.86149410 |
| 77 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.85291145 |
| 78 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.84700932 |
| 79 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.84378612 |
| 80 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.82761557 |
| 81 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.81513009 |
| 82 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.80262703 |
| 83 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.79560148 |
| 84 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.77503342 |
| 85 | NCOR_22424771_ChIP-Seq_293T_Human | 0.77421662 |
| 86 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.77200353 |
| 87 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.73968403 |
| 88 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.73691308 |
| 89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.72737957 |
| 90 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.72189646 |
| 91 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.71626355 |
| 92 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.70881962 |
| 93 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.70327728 |
| 94 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.70327728 |
| 95 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.70327728 |
| 96 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.70105525 |
| 97 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.69714759 |
| 98 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.68484569 |
| 99 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.66605057 |
| 100 | P68_20966046_ChIP-Seq_HELA_Human | 0.66408966 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005670_abnormal_white_adipose | 4.93700241 |
| 2 | MP0005360_urolithiasis | 4.66266681 |
| 3 | MP0005646_abnormal_pituitary_gland | 3.79340849 |
| 4 | MP0003806_abnormal_nucleotide_metabolis | 3.42995873 |
| 5 | MP0002938_white_spotting | 3.20173677 |
| 6 | MP0003183_abnormal_peptide_metabolism | 3.03850504 |
| 7 | MP0003705_abnormal_hypodermis_morpholog | 3.03625737 |
| 8 | MP0004147_increased_porphyrin_level | 2.86165548 |
| 9 | MP0008995_early_reproductive_senescence | 2.81667506 |
| 10 | MP0002736_abnormal_nociception_after | 2.62943217 |
| 11 | MP0003186_abnormal_redox_activity | 2.59622453 |
| 12 | MP0001661_extended_life_span | 2.36152123 |
| 13 | MP0009379_abnormal_foot_pigmentation | 2.32590759 |
| 14 | MP0000647_abnormal_sebaceous_gland | 2.24620774 |
| 15 | MP0006292_abnormal_olfactory_placode | 2.19024795 |
| 16 | MP0000013_abnormal_adipose_tissue | 2.15000148 |
| 17 | MP0004185_abnormal_adipocyte_glucose | 2.11333390 |
| 18 | MP0003693_abnormal_embryo_hatching | 2.11004117 |
| 19 | MP0005332_abnormal_amino_acid | 2.05840455 |
| 20 | MP0004885_abnormal_endolymph | 2.04726794 |
| 21 | MP0009053_abnormal_anal_canal | 1.96824601 |
| 22 | MP0005367_renal/urinary_system_phenotyp | 1.95176645 |
| 23 | MP0000516_abnormal_urinary_system | 1.95176645 |
| 24 | MP0008872_abnormal_physiological_respon | 1.82444712 |
| 25 | MP0002396_abnormal_hematopoietic_system | 1.82225185 |
| 26 | MP0002160_abnormal_reproductive_system | 1.81798248 |
| 27 | MP0005377_hearing/vestibular/ear_phenot | 1.75989216 |
| 28 | MP0003878_abnormal_ear_physiology | 1.75989216 |
| 29 | MP0001764_abnormal_homeostasis | 1.70261790 |
| 30 | MP0002837_dystrophic_cardiac_calcinosis | 1.65158976 |
| 31 | MP0003786_premature_aging | 1.59061886 |
| 32 | MP0004019_abnormal_vitamin_homeostasis | 1.54904400 |
| 33 | MP0000534_abnormal_ureter_morphology | 1.52312517 |
| 34 | MP0002735_abnormal_chemical_nociception | 1.47936170 |
| 35 | MP0004957_abnormal_blastocyst_morpholog | 1.44704384 |
| 36 | MP0003942_abnormal_urinary_system | 1.42601449 |
| 37 | MP0008058_abnormal_DNA_repair | 1.40881853 |
| 38 | MP0001968_abnormal_touch/_nociception | 1.35973541 |
| 39 | MP0003111_abnormal_nucleus_morphology | 1.33852524 |
| 40 | MP0003937_abnormal_limbs/digits/tail_de | 1.30998175 |
| 41 | MP0000678_abnormal_parathyroid_gland | 1.25035612 |
| 42 | MP0000631_abnormal_neuroendocrine_gland | 1.19843426 |
| 43 | MP0002095_abnormal_skin_pigmentation | 1.19299492 |
| 44 | MP0001293_anophthalmia | 1.15083046 |
| 45 | MP0005636_abnormal_mineral_homeostasis | 1.13455998 |
| 46 | MP0005085_abnormal_gallbladder_physiolo | 1.12402118 |
| 47 | MP0003567_abnormal_fetal_cardiomyocyte | 1.11279594 |
| 48 | MP0004133_heterotaxia | 1.10532438 |
| 49 | MP0005187_abnormal_penis_morphology | 1.09368119 |
| 50 | MP0004043_abnormal_pH_regulation | 1.08531754 |
| 51 | MP0002132_abnormal_respiratory_system | 1.06150503 |
| 52 | MP0000049_abnormal_middle_ear | 1.04423295 |
| 53 | MP0003880_abnormal_central_pattern | 1.03028615 |
| 54 | MP0003123_paternal_imprinting | 1.02272432 |
| 55 | MP0006036_abnormal_mitochondrial_physio | 1.00693297 |
| 56 | MP0001145_abnormal_male_reproductive | 0.97892527 |
| 57 | MP0002697_abnormal_eye_size | 0.97566285 |
| 58 | MP0002210_abnormal_sex_determination | 0.96665799 |
| 59 | MP0009697_abnormal_copulation | 0.96442313 |
| 60 | MP0003077_abnormal_cell_cycle | 0.94889738 |
| 61 | MP0005410_abnormal_fertilization | 0.93427102 |
| 62 | MP0005389_reproductive_system_phenotype | 0.93101440 |
| 63 | MP0006276_abnormal_autonomic_nervous | 0.93087304 |
| 64 | MP0000026_abnormal_inner_ear | 0.92612217 |
| 65 | MP0000653_abnormal_sex_gland | 0.90792160 |
| 66 | MP0000762_abnormal_tongue_morphology | 0.90092238 |
| 67 | MP0008932_abnormal_embryonic_tissue | 0.85889256 |
| 68 | MP0003283_abnormal_digestive_organ | 0.85715768 |
| 69 | MP0000750_abnormal_muscle_regeneration | 0.83228233 |
| 70 | MP0005551_abnormal_eye_electrophysiolog | 0.82648918 |
| 71 | MP0003718_maternal_effect | 0.81787017 |
| 72 | MP0009250_abnormal_appendicular_skeleto | 0.81497410 |
| 73 | MP0009643_abnormal_urine_homeostasis | 0.81495217 |
| 74 | MP0002234_abnormal_pharynx_morphology | 0.81438477 |
| 75 | MP0001270_distended_abdomen | 0.78147234 |
| 76 | MP0003315_abnormal_perineum_morphology | 0.77588234 |
| 77 | MP0010094_abnormal_chromosome_stability | 0.77394166 |
| 78 | MP0006035_abnormal_mitochondrial_morpho | 0.76661715 |
| 79 | MP0010030_abnormal_orbit_morphology | 0.74853881 |
| 80 | MP0004233_abnormal_muscle_weight | 0.74787889 |
| 81 | MP0005084_abnormal_gallbladder_morpholo | 0.74559164 |
| 82 | MP0003724_increased_susceptibility_to | 0.72100951 |
| 83 | MP0001666_abnormal_nutrient_absorption | 0.71873383 |
| 84 | MP0001756_abnormal_urination | 0.71315828 |
| 85 | MP0001944_abnormal_pancreas_morphology | 0.71163336 |
| 86 | MP0003890_abnormal_embryonic-extraembry | 0.70245895 |
| 87 | MP0001919_abnormal_reproductive_system | 0.69632914 |
| 88 | MP0001485_abnormal_pinna_reflex | 0.69092043 |
| 89 | MP0003698_abnormal_male_reproductive | 0.68506241 |
| 90 | MP0002277_abnormal_respiratory_mucosa | 0.68420148 |
| 91 | MP0002249_abnormal_larynx_morphology | 0.67420682 |
| 92 | MP0008875_abnormal_xenobiotic_pharmacok | 0.67101615 |
| 93 | MP0000003_abnormal_adipose_tissue | 0.65556323 |
| 94 | MP0005365_abnormal_bile_salt | 0.64754134 |
| 95 | MP0003936_abnormal_reproductive_system | 0.63653891 |
| 96 | MP0002138_abnormal_hepatobiliary_system | 0.62719513 |
| 97 | MP0003638_abnormal_response/metabolism_ | 0.62213199 |
| 98 | MP0001963_abnormal_hearing_physiology | 0.61674135 |
| 99 | MP0002139_abnormal_hepatobiliary_system | 0.60619236 |
| 100 | MP0001929_abnormal_gametogenesis | 0.59529465 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of alanine metabolism (HP:0010916) | 8.01633878 |
| 2 | Hyperalaninemia (HP:0003348) | 8.01633878 |
| 3 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 8.01633878 |
| 4 | Abnormal umbilical cord blood vessels (HP:0011403) | 5.53367088 |
| 5 | Single umbilical artery (HP:0001195) | 5.53367088 |
| 6 | Abnormality of the fetal cardiovascular system (HP:0010948) | 5.53367088 |
| 7 | Constricted visual fields (HP:0001133) | 5.07348090 |
| 8 | Congenital sensorineural hearing impairment (HP:0008527) | 4.29874567 |
| 9 | Esophageal varix (HP:0002040) | 4.26306168 |
| 10 | Abnormality of the umbilical cord (HP:0010881) | 4.01635778 |
| 11 | Abnormality of serum amino acid levels (HP:0003112) | 3.97877800 |
| 12 | Abnormality of homocysteine metabolism (HP:0010919) | 3.83114163 |
| 13 | Homocystinuria (HP:0002156) | 3.83114163 |
| 14 | Birth length less than 3rd percentile (HP:0003561) | 3.76186810 |
| 15 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 3.73048153 |
| 16 | Abnormality of the phalanges of the hallux (HP:0010057) | 3.47788705 |
| 17 | Generalized aminoaciduria (HP:0002909) | 3.46672289 |
| 18 | White forelock (HP:0002211) | 3.32055080 |
| 19 | Patchy hypopigmentation of hair (HP:0011365) | 3.24726032 |
| 20 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 3.06776427 |
| 21 | Increased serum pyruvate (HP:0003542) | 3.04698131 |
| 22 | Spontaneous hematomas (HP:0007420) | 2.99983702 |
| 23 | Acute necrotizing encephalopathy (HP:0006965) | 2.99843255 |
| 24 | Maternal diabetes (HP:0009800) | 2.99128432 |
| 25 | Nausea (HP:0002018) | 2.90778125 |
| 26 | Acute encephalopathy (HP:0006846) | 2.88526573 |
| 27 | Hyperglycinemia (HP:0002154) | 2.80168523 |
| 28 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.78179317 |
| 29 | Reticulocytopenia (HP:0001896) | 2.71291884 |
| 30 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.70381325 |
| 31 | Anorexia (HP:0002039) | 2.63299828 |
| 32 | Abnormalities of placenta or umbilical cord (HP:0001194) | 2.62552764 |
| 33 | Abnormality of glycolysis (HP:0004366) | 2.58427842 |
| 34 | Myocardial infarction (HP:0001658) | 2.56790077 |
| 35 | Conjugated hyperbilirubinemia (HP:0002908) | 2.56176815 |
| 36 | Poor speech (HP:0002465) | 2.48216153 |
| 37 | Proximal tubulopathy (HP:0000114) | 2.46022530 |
| 38 | Increased serum lactate (HP:0002151) | 2.42743320 |
| 39 | Hypoplastic left heart (HP:0004383) | 2.42658410 |
| 40 | Macrocytic anemia (HP:0001972) | 2.37338991 |
| 41 | Conjunctival telangiectasia (HP:0000524) | 2.36874649 |
| 42 | Cavernous hemangioma (HP:0001048) | 2.35147637 |
| 43 | Progressive macrocephaly (HP:0004481) | 2.34122670 |
| 44 | Mitochondrial inheritance (HP:0001427) | 2.33772027 |
| 45 | Tetany (HP:0001281) | 2.32383057 |
| 46 | Lactic acidosis (HP:0003128) | 2.29948837 |
| 47 | Increased CSF lactate (HP:0002490) | 2.24035296 |
| 48 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.22160928 |
| 49 | Cerebral edema (HP:0002181) | 2.21053957 |
| 50 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.20725554 |
| 51 | Methylmalonic acidemia (HP:0002912) | 2.15624519 |
| 52 | Anencephaly (HP:0002323) | 2.09944957 |
| 53 | Hyperphosphaturia (HP:0003109) | 2.09213929 |
| 54 | Metabolic acidosis (HP:0001942) | 2.09093885 |
| 55 | Cortical visual impairment (HP:0100704) | 2.06727688 |
| 56 | Hepatic necrosis (HP:0002605) | 2.06353368 |
| 57 | Short middle phalanx of the 5th finger (HP:0004220) | 2.06305278 |
| 58 | Hypomagnesemia (HP:0002917) | 2.05892259 |
| 59 | Esophageal atresia (HP:0002032) | 2.03993036 |
| 60 | Chronic hepatic failure (HP:0100626) | 2.03822090 |
| 61 | Hypoalphalipoproteinemia (HP:0003233) | 2.03820105 |
| 62 | Occipital encephalocele (HP:0002085) | 1.98768058 |
| 63 | Paralysis (HP:0003470) | 1.98206450 |
| 64 | Hepatocellular necrosis (HP:0001404) | 1.98090509 |
| 65 | Stenosis of the external auditory canal (HP:0000402) | 1.97778556 |
| 66 | Lethargy (HP:0001254) | 1.97148002 |
| 67 | Pallor (HP:0000980) | 1.95061114 |
| 68 | Action tremor (HP:0002345) | 1.94109806 |
| 69 | Chorioretinal atrophy (HP:0000533) | 1.93241868 |
| 70 | Abnormal tarsal ossification (HP:0008369) | 1.86489360 |
| 71 | Hypoplastic heart (HP:0001961) | 1.86328898 |
| 72 | 3-Methylglutaconic aciduria (HP:0003535) | 1.85812723 |
| 73 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.85767166 |
| 74 | Decreased subcutaneous fat (HP:0001002) | 1.85158259 |
| 75 | Ectopic kidney (HP:0000086) | 1.84673191 |
| 76 | Megaloblastic anemia (HP:0001889) | 1.84221922 |
| 77 | Abnormality of the middle phalanges of the toes (HP:0010183) | 1.82980328 |
| 78 | Methylmalonic aciduria (HP:0012120) | 1.82934601 |
| 79 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.82443712 |
| 80 | Glycosuria (HP:0003076) | 1.82219253 |
| 81 | Abnormality of urine glucose concentration (HP:0011016) | 1.82219253 |
| 82 | Pendular nystagmus (HP:0012043) | 1.81008633 |
| 83 | Oligomenorrhea (HP:0000876) | 1.80490749 |
| 84 | Abnormality of magnesium homeostasis (HP:0004921) | 1.80079330 |
| 85 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.79227348 |
| 86 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.79227348 |
| 87 | Triphalangeal thumb (HP:0001199) | 1.78509532 |
| 88 | Abnormality of cochlea (HP:0000375) | 1.77052173 |
| 89 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.76356243 |
| 90 | Type I transferrin isoform profile (HP:0003642) | 1.76329967 |
| 91 | Abnormality of glycine metabolism (HP:0010895) | 1.74157090 |
| 92 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.74157090 |
| 93 | Broad distal phalanx of finger (HP:0009836) | 1.73804408 |
| 94 | Ileus (HP:0002595) | 1.73734953 |
| 95 | Insulin-resistant diabetes mellitus (HP:0000831) | 1.69828904 |
| 96 | Abnormal number of erythroid precursors (HP:0012131) | 1.69438330 |
| 97 | Exercise intolerance (HP:0003546) | 1.69221311 |
| 98 | Duplication of thumb phalanx (HP:0009942) | 1.67923160 |
| 99 | Bone marrow hypocellularity (HP:0005528) | 1.67302561 |
| 100 | Partial duplication of thumb phalanx (HP:0009944) | 1.63972133 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.84948225 |
| 2 | MAP3K3 | 3.49021430 |
| 3 | RPS6KB2 | 3.33197458 |
| 4 | MAP2K3 | 2.78572114 |
| 5 | ACVR1B | 2.74305450 |
| 6 | CDC7 | 2.73319632 |
| 7 | WNK4 | 2.63411165 |
| 8 | CDK9 | 2.46995870 |
| 9 | TAF1 | 2.38923159 |
| 10 | BCKDK | 2.35309662 |
| 11 | NME2 | 2.33263439 |
| 12 | STK39 | 2.27193325 |
| 13 | NUAK1 | 2.22127071 |
| 14 | BUB1 | 2.21096395 |
| 15 | PDK2 | 2.16890535 |
| 16 | FGR | 2.03817621 |
| 17 | EPHB2 | 1.99832752 |
| 18 | OXSR1 | 1.95711974 |
| 19 | EPHA2 | 1.95015831 |
| 20 | PBK | 1.81967827 |
| 21 | MUSK | 1.79853488 |
| 22 | JAK3 | 1.51324461 |
| 23 | NTRK2 | 1.50779912 |
| 24 | NEK1 | 1.43881403 |
| 25 | VRK1 | 1.42034172 |
| 26 | AURKA | 1.39821676 |
| 27 | TLK1 | 1.35325938 |
| 28 | DYRK2 | 1.26669276 |
| 29 | NME1 | 1.20693537 |
| 30 | SGK223 | 1.17138975 |
| 31 | SGK494 | 1.17138975 |
| 32 | PAK4 | 1.16841258 |
| 33 | CCNB1 | 1.15747758 |
| 34 | MST4 | 1.14817174 |
| 35 | PRKCI | 1.14536721 |
| 36 | INSRR | 1.12796175 |
| 37 | GRK1 | 1.06742818 |
| 38 | TNIK | 1.03044183 |
| 39 | LMTK2 | 1.02426157 |
| 40 | ADRBK1 | 1.01088884 |
| 41 | CHEK2 | 1.01042703 |
| 42 | CDK19 | 0.98764220 |
| 43 | MAP4K2 | 0.96032555 |
| 44 | EIF2AK1 | 0.91223215 |
| 45 | CAMK1 | 0.90021343 |
| 46 | NTRK3 | 0.86790831 |
| 47 | SGK2 | 0.85837791 |
| 48 | TRIM28 | 0.85468149 |
| 49 | STK16 | 0.83469138 |
| 50 | ZAK | 0.82036811 |
| 51 | SMG1 | 0.81604965 |
| 52 | CSNK1A1 | 0.80853073 |
| 53 | MAP2K1 | 0.80792320 |
| 54 | CDK7 | 0.80285910 |
| 55 | SRPK1 | 0.78318200 |
| 56 | WNK3 | 0.76957943 |
| 57 | DAPK1 | 0.76535929 |
| 58 | PLK4 | 0.74734242 |
| 59 | NEK6 | 0.73071587 |
| 60 | MAP3K11 | 0.72716657 |
| 61 | DAPK3 | 0.72691456 |
| 62 | CAMK2G | 0.71789360 |
| 63 | ABL2 | 0.71692524 |
| 64 | PLK1 | 0.69672418 |
| 65 | ADRBK2 | 0.69156113 |
| 66 | CAMK2B | 0.68747939 |
| 67 | PLK3 | 0.64236775 |
| 68 | AKT2 | 0.62224108 |
| 69 | CAMK2D | 0.60235273 |
| 70 | AURKB | 0.60235121 |
| 71 | CSNK1G3 | 0.58340032 |
| 72 | PTK6 | 0.57478768 |
| 73 | GRK5 | 0.55598869 |
| 74 | PIK3CA | 0.54966209 |
| 75 | CSNK2A1 | 0.54950313 |
| 76 | BMPR1B | 0.50060581 |
| 77 | SGK3 | 0.49776720 |
| 78 | IRAK2 | 0.48856781 |
| 79 | TTK | 0.48552679 |
| 80 | BRSK1 | 0.46845266 |
| 81 | CSNK2A2 | 0.46522386 |
| 82 | RPS6KB1 | 0.45394935 |
| 83 | PRKCE | 0.43606500 |
| 84 | PHKG1 | 0.42799237 |
| 85 | PHKG2 | 0.42799237 |
| 86 | ATR | 0.42698046 |
| 87 | PRKCD | 0.42241625 |
| 88 | BRSK2 | 0.39244982 |
| 89 | PASK | 0.38703523 |
| 90 | CSNK1G2 | 0.37502601 |
| 91 | CSNK1G1 | 0.36972101 |
| 92 | PINK1 | 0.35664540 |
| 93 | MAP2K7 | 0.35149716 |
| 94 | MAPKAPK5 | 0.34594257 |
| 95 | ILK | 0.32415619 |
| 96 | PLK2 | 0.32324065 |
| 97 | CDK4 | 0.30869409 |
| 98 | KDR | 0.29382932 |
| 99 | IRAK3 | 0.28983163 |
| 100 | PRKCA | 0.27794071 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.06886867 |
| 2 | One carbon pool by folate_Homo sapiens_hsa00670 | 3.70862663 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.61150245 |
| 4 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 3.16440477 |
| 5 | Proteasome_Homo sapiens_hsa03050 | 2.91026802 |
| 6 | Sulfur relay system_Homo sapiens_hsa04122 | 2.73457389 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.53875255 |
| 8 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.33067329 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.27284068 |
| 10 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.16115845 |
| 11 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.14288524 |
| 12 | Selenocompound metabolism_Homo sapiens_hsa00450 | 2.14204954 |
| 13 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.03962869 |
| 14 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.01110510 |
| 15 | Huntingtons disease_Homo sapiens_hsa05016 | 2.01001603 |
| 16 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.92961482 |
| 17 | RNA polymerase_Homo sapiens_hsa03020 | 1.71845770 |
| 18 | Alzheimers disease_Homo sapiens_hsa05010 | 1.68878670 |
| 19 | DNA replication_Homo sapiens_hsa03030 | 1.62737561 |
| 20 | Spliceosome_Homo sapiens_hsa03040 | 1.59472774 |
| 21 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.57570947 |
| 22 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.54743456 |
| 23 | Galactose metabolism_Homo sapiens_hsa00052 | 1.51022722 |
| 24 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.47261565 |
| 25 | Base excision repair_Homo sapiens_hsa03410 | 1.41044779 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.40618396 |
| 27 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.40068233 |
| 28 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.36174434 |
| 29 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.35557984 |
| 30 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.26237378 |
| 31 | Homologous recombination_Homo sapiens_hsa03440 | 1.24851677 |
| 32 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.23633436 |
| 33 | RNA degradation_Homo sapiens_hsa03018 | 1.21960338 |
| 34 | RNA transport_Homo sapiens_hsa03013 | 1.20093096 |
| 35 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.19849005 |
| 36 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.18925134 |
| 37 | Basal transcription factors_Homo sapiens_hsa03022 | 1.18782415 |
| 38 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.16063181 |
| 39 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.12169369 |
| 40 | Retinol metabolism_Homo sapiens_hsa00830 | 1.10831262 |
| 41 | Protein export_Homo sapiens_hsa03060 | 1.09182567 |
| 42 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.03833927 |
| 43 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.03045104 |
| 44 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.01701761 |
| 45 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.01414611 |
| 46 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.98269846 |
| 47 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.97308022 |
| 48 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.95715141 |
| 49 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.94745018 |
| 50 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.94729778 |
| 51 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.93248756 |
| 52 | Metabolic pathways_Homo sapiens_hsa01100 | 0.92263375 |
| 53 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.92194648 |
| 54 | Mismatch repair_Homo sapiens_hsa03430 | 0.90759346 |
| 55 | Nicotine addiction_Homo sapiens_hsa05033 | 0.84472675 |
| 56 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.83537082 |
| 57 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.82342735 |
| 58 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.82208911 |
| 59 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.77786217 |
| 60 | GABAergic synapse_Homo sapiens_hsa04727 | 0.77540648 |
| 61 | Morphine addiction_Homo sapiens_hsa05032 | 0.77374464 |
| 62 | Peroxisome_Homo sapiens_hsa04146 | 0.73637927 |
| 63 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.73525911 |
| 64 | Purine metabolism_Homo sapiens_hsa00230 | 0.72818775 |
| 65 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.72402778 |
| 66 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.71271473 |
| 67 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.69191804 |
| 68 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.66715532 |
| 69 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.63303218 |
| 70 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.63187656 |
| 71 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.62865816 |
| 72 | Carbon metabolism_Homo sapiens_hsa01200 | 0.58194737 |
| 73 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.57873919 |
| 74 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.57582478 |
| 75 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.57306121 |
| 76 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.57291723 |
| 77 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.57250996 |
| 78 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.53108735 |
| 79 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.52062139 |
| 80 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.49689840 |
| 81 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.49501760 |
| 82 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.49338815 |
| 83 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.48859892 |
| 84 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.48506558 |
| 85 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.48463964 |
| 86 | Olfactory transduction_Homo sapiens_hsa04740 | 0.48245442 |
| 87 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.46518424 |
| 88 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.46111714 |
| 89 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.45086660 |
| 90 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.42217502 |
| 91 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.40764271 |
| 92 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.40550921 |
| 93 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.36953236 |
| 94 | Thyroid cancer_Homo sapiens_hsa05216 | 0.36619194 |
| 95 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.36043367 |
| 96 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.35305461 |
| 97 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.32317954 |
| 98 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.31435244 |
| 99 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.30758695 |
| 100 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.29394149 |

