KRT18P31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hepatocyte apoptotic process (GO:0097284)5.48867681
2protein K11-linked deubiquitination (GO:0035871)5.26447280
3interferon-gamma production (GO:0032609)4.90328293
4positive regulation of gamma-delta T cell activation (GO:0046645)4.87459921
5histone H3-K36 demethylation (GO:0070544)4.81237689
6regulation of B cell receptor signaling pathway (GO:0050855)4.54858212
7nuclear pore complex assembly (GO:0051292)4.50701462
8phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.50668469
9monoubiquitinated protein deubiquitination (GO:0035520)4.49283139
10negative regulation of cell killing (GO:0031342)4.36004462
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.36004462
12regulation of gamma-delta T cell differentiation (GO:0045586)4.16175923
13protein K48-linked deubiquitination (GO:0071108)4.15194996
14histone mRNA catabolic process (GO:0071044)3.97470708
15rRNA catabolic process (GO:0016075)3.83575035
16cellular response to ethanol (GO:0071361)3.76996340
17nuclear pore organization (GO:0006999)3.73726757
18regulation of gamma-delta T cell activation (GO:0046643)3.66624453
19positive regulation of granulocyte differentiation (GO:0030854)3.64133451
20establishment of protein localization to vacuole (GO:0072666)3.60236754
21protein targeting to vacuole (GO:0006623)3.60236754
22protein targeting to lysosome (GO:0006622)3.60236754
23cellular response to interleukin-15 (GO:0071350)3.57778004
24detection of molecule of bacterial origin (GO:0032490)3.49642373
25cytoplasmic mRNA processing body assembly (GO:0033962)3.48438890
26positive T cell selection (GO:0043368)3.44524808
27dosage compensation (GO:0007549)3.42887198
28pericardium development (GO:0060039)3.41788655
29histone H3-K4 trimethylation (GO:0080182)3.41755766
30response to interleukin-15 (GO:0070672)3.41281334
31negative T cell selection (GO:0043383)3.41135101
32B cell receptor signaling pathway (GO:0050853)3.37244045
33protein K63-linked deubiquitination (GO:0070536)3.35702861
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32048907
35negative thymic T cell selection (GO:0045060)3.24502252
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.24267194
37myeloid leukocyte mediated immunity (GO:0002444)3.22975477
38pore complex assembly (GO:0046931)3.22500434
39regulation of interleukin-12 biosynthetic process (GO:0045075)3.19185235
40histone-serine phosphorylation (GO:0035404)3.15991925
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.12710504
42natural killer cell activation involved in immune response (GO:0002323)3.12217481
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12029785
44neutrophil mediated immunity (GO:0002446)3.10980006
45interkinetic nuclear migration (GO:0022027)3.09647269
46positive regulation of alpha-beta T cell proliferation (GO:0046641)3.05890878
47positive thymic T cell selection (GO:0045059)3.00657471
48peptidyl-lysine trimethylation (GO:0018023)2.99964955
49microglial cell activation (GO:0001774)2.99503183
50cellular extravasation (GO:0045123)2.96661231
51muscle atrophy (GO:0014889)2.96237328
52striated muscle atrophy (GO:0014891)2.95502433
53regulation of alpha-beta T cell proliferation (GO:0046640)2.93208025
54establishment of protein localization to Golgi (GO:0072600)2.90876091
55negative regulation of DNA repair (GO:0045738)2.88452532
56replicative senescence (GO:0090399)2.85335846
57positive regulation of developmental pigmentation (GO:0048087)2.84723325
58mast cell degranulation (GO:0043303)2.84311906
59mast cell activation involved in immune response (GO:0002279)2.84311906
60mast cell activation (GO:0045576)2.83719566
61prenylation (GO:0097354)2.83254717
62protein prenylation (GO:0018342)2.83254717
63regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.81772666
64skeletal muscle adaptation (GO:0043501)2.80014704
65negative regulation of B cell proliferation (GO:0030889)2.78022903
66regulation of necroptotic process (GO:0060544)2.76793730
67macrophage activation (GO:0042116)2.76095131
68alpha-beta T cell activation (GO:0046631)2.75647249
69histone H3-K4 methylation (GO:0051568)2.72981467
70negative regulation of myotube differentiation (GO:0010832)2.70600271
71positive regulation of B cell differentiation (GO:0045579)2.68395189
72mitochondrion distribution (GO:0048311)2.67931787
73histone H4-K16 acetylation (GO:0043984)2.67384553
74alternative mRNA splicing, via spliceosome (GO:0000380)2.64993091
75positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.64848094
76neural tube formation (GO:0001841)2.62857472
77macrophage activation involved in immune response (GO:0002281)2.60641592
78T cell selection (GO:0045058)2.57436820
79peptidyl-lysine methylation (GO:0018022)2.57051599
80energy homeostasis (GO:0097009)2.56126278
81T cell migration (GO:0072678)2.55853610
82mature B cell differentiation (GO:0002335)2.55276836
83fibroblast migration (GO:0010761)2.54955123
84negative regulation of lymphocyte mediated immunity (GO:0002707)2.54200062
85myeloid cell activation involved in immune response (GO:0002275)2.52093840
86leukocyte degranulation (GO:0043299)2.50577569
87tryptophan metabolic process (GO:0006568)2.49882161
88ncRNA catabolic process (GO:0034661)2.49830605
89adenosine metabolic process (GO:0046085)2.49770306
90regulation of interleukin-6 biosynthetic process (GO:0045408)2.49674257
91negative regulation of TOR signaling (GO:0032007)2.49335298
92positive regulation of DNA-templated transcription, initiation (GO:2000144)2.48986589
93regulation of B cell differentiation (GO:0045577)2.48391696
94regulation of pigment cell differentiation (GO:0050932)2.48102778
95cAMP catabolic process (GO:0006198)2.47944431
96pre-miRNA processing (GO:0031054)2.47184771
97T cell proliferation (GO:0042098)2.47054230
98DNA demethylation (GO:0080111)2.47006644
99protein destabilization (GO:0031648)2.46393198
100positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.45691048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.96805979
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.13294592
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.87792309
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.68490014
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.67454430
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.55596354
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.39279054
8RUNX_20019798_ChIP-Seq_JUKART_Human2.78268713
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.70033410
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.44170878
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34115977
12GATA1_22025678_ChIP-Seq_K562_Human2.30290153
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25409811
14E2F7_22180533_ChIP-Seq_HELA_Human2.22291861
15TP53_16413492_ChIP-PET_HCT116_Human2.20565511
16SCL_19346495_ChIP-Seq_HPC-7_Human2.12146742
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.10652719
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.05431442
19MYB_26560356_Chip-Seq_TH2_Human1.97897452
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91568356
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84824035
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77442961
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.75090225
24MYB_26560356_Chip-Seq_TH1_Human1.63861892
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59429949
26GATA3_27048872_Chip-Seq_THYMUS_Human1.57461790
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54695926
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53374060
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51498530
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51117449
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47339531
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44587952
33VDR_24787735_ChIP-Seq_THP-1_Human1.44031115
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41588449
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.40586699
36AHR_22903824_ChIP-Seq_MCF-7_Human1.36276842
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35850191
38RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35710221
39FUS_26573619_Chip-Seq_HEK293_Human1.32503185
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31789647
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30311329
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.28996560
43GATA3_26560356_Chip-Seq_TH2_Human1.28872652
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28221129
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25529207
46ER_23166858_ChIP-Seq_MCF-7_Human1.24410980
47STAT3_23295773_ChIP-Seq_U87_Human1.22576547
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20093829
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19981038
50TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19612984
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17553230
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14708176
53CIITA_25753668_ChIP-Seq_RAJI_Human1.14201560
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.12704728
55CBP_20019798_ChIP-Seq_JUKART_Human1.12392095
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12392095
57SPI1_23547873_ChIP-Seq_NB4_Human1.12345521
58EWS_26573619_Chip-Seq_HEK293_Human1.12339440
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11477148
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.10811607
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09718276
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09455618
63IGF1R_20145208_ChIP-Seq_DFB_Human1.08537787
64TCF4_23295773_ChIP-Seq_U87_Human1.07779978
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07414882
66SPI1_23127762_ChIP-Seq_K562_Human1.07372582
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.07062122
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03304832
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.03163634
70P300_19829295_ChIP-Seq_ESCs_Human1.02921260
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.02315962
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02217130
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02087499
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01566297
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00112100
76TAF15_26573619_Chip-Seq_HEK293_Human1.00085114
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99962099
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99671070
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99373464
80FLI1_21867929_ChIP-Seq_TH2_Mouse0.98961938
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98774428
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97806695
83OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97598224
84PRDM14_20953172_ChIP-Seq_ESCs_Human0.97441742
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96597938
86ELK1_19687146_ChIP-ChIP_HELA_Human0.96528616
87CDX2_22108803_ChIP-Seq_LS180_Human0.96134874
88PU_27001747_Chip-Seq_BMDM_Mouse0.95986527
89GATA2_19941826_ChIP-Seq_K562_Human0.95629366
90IRF1_19129219_ChIP-ChIP_H3396_Human0.94894021
91SMAD4_21799915_ChIP-Seq_A2780_Human0.94487918
92BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94011513
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.93013020
94GATA3_26560356_Chip-Seq_TH1_Human0.92668871
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.92039480
96MAF_26560356_Chip-Seq_TH1_Human0.91855497
97PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90737941
98FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90269214
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89794891
100VDR_23849224_ChIP-Seq_CD4+_Human0.89501595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.38705322
2MP0008057_abnormal_DNA_replication4.67968985
3MP0003763_abnormal_thymus_physiology3.38514257
4MP0002396_abnormal_hematopoietic_system2.99479439
5MP0003656_abnormal_erythrocyte_physiolo2.81695038
6MP0003724_increased_susceptibility_to2.62558056
7MP0005075_abnormal_melanosome_morpholog2.62021835
8MP0001835_abnormal_antigen_presentation2.18371669
9MP0004043_abnormal_pH_regulation2.12840275
10MP0001800_abnormal_humoral_immune2.12818902
11MP0004808_abnormal_hematopoietic_stem2.01243964
12MP0003646_muscle_fatigue1.97148615
13MP0004130_abnormal_muscle_cell1.90531577
14MP0003828_pulmonary_edema1.89991966
15MP0004381_abnormal_hair_follicle1.81231992
16MP0000371_diluted_coat_color1.81223875
17MP0002009_preneoplasia1.80541273
18MP0000383_abnormal_hair_follicle1.77790642
19MP0005671_abnormal_response_to1.76967697
20MP0010094_abnormal_chromosome_stability1.75666096
21MP0000685_abnormal_immune_system1.74811242
22MP0004233_abnormal_muscle_weight1.73247542
23MP0002398_abnormal_bone_marrow1.71430433
24MP0005174_abnormal_tail_pigmentation1.70118793
25MP0008995_early_reproductive_senescence1.69831364
26MP0000703_abnormal_thymus_morphology1.66531455
27MP0005076_abnormal_cell_differentiation1.64515482
28MP0005083_abnormal_biliary_tract1.63028859
29MP0000015_abnormal_ear_pigmentation1.57958299
30MP0002166_altered_tumor_susceptibility1.56861933
31MP0000689_abnormal_spleen_morphology1.55926109
32MP0002722_abnormal_immune_system1.53316744
33MP0003890_abnormal_embryonic-extraembry1.52724355
34MP0002723_abnormal_immune_serum1.52598292
35MP0008058_abnormal_DNA_repair1.50550336
36MP0002420_abnormal_adaptive_immunity1.50538116
37MP0001819_abnormal_immune_cell1.47544862
38MP0005000_abnormal_immune_tolerance1.47414860
39MP0001661_extended_life_span1.46401679
40MP0002452_abnormal_antigen_presenting1.45848930
41MP0000716_abnormal_immune_system1.45454782
42MP0003786_premature_aging1.44170984
43MP0002405_respiratory_system_inflammati1.40502113
44MP0003195_calcinosis1.40307301
45MP0010678_abnormal_skin_adnexa1.35386412
46MP0000372_irregular_coat_pigmentation1.32265454
47MP0004484_altered_response_of1.31963568
48MP0008260_abnormal_autophagy1.28081636
49MP0002332_abnormal_exercise_endurance1.25304257
50MP0010307_abnormal_tumor_latency1.20902851
51MP0002429_abnormal_blood_cell1.19351689
52MP0002419_abnormal_innate_immunity1.18802427
53MP0000427_abnormal_hair_cycle1.18699990
54MP0000013_abnormal_adipose_tissue1.12515848
55MP0003436_decreased_susceptibility_to1.09882650
56MP0002006_tumorigenesis1.09580878
57MP0004147_increased_porphyrin_level1.09093182
58MP0009697_abnormal_copulation1.08508485
59MP0009115_abnormal_fat_cell1.08294106
60MP0001851_eye_inflammation1.06893723
61MP0005408_hypopigmentation1.06545412
62MP0005310_abnormal_salivary_gland1.05141818
63MP0005253_abnormal_eye_physiology1.04525119
64MP0000465_gastrointestinal_hemorrhage1.03058063
65MP0001790_abnormal_immune_system1.02988011
66MP0005387_immune_system_phenotype1.02988011
67MP0006054_spinal_hemorrhage1.02123785
68MP0006072_abnormal_retinal_apoptosis1.02102513
69MP0008877_abnormal_DNA_methylation0.99481366
70MP0005025_abnormal_response_to0.97384370
71MP0005397_hematopoietic_system_phenotyp0.96468212
72MP0001545_abnormal_hematopoietic_system0.96468212
73MP0002019_abnormal_tumor_incidence0.95870508
74MP0009764_decreased_sensitivity_to0.95773499
75MP0003221_abnormal_cardiomyocyte_apopto0.95561094
76MP0003077_abnormal_cell_cycle0.91959415
77MP0002095_abnormal_skin_pigmentation0.90711997
78MP0004264_abnormal_extraembryonic_tissu0.86713320
79MP0003111_abnormal_nucleus_morphology0.83766322
80MP0000003_abnormal_adipose_tissue0.82907998
81MP0001845_abnormal_inflammatory_respons0.81269851
82MP0002075_abnormal_coat/hair_pigmentati0.81094238
83MP0005334_abnormal_fat_pad0.80246559
84MP0001853_heart_inflammation0.76021696
85MP0003172_abnormal_lysosome_physiology0.74553753
86MP0003787_abnormal_imprinting0.74069853
87MP0005266_abnormal_metabolism0.73514096
88MP0009765_abnormal_xenobiotic_induced0.72631952
89MP0003632_abnormal_nervous_system0.71559910
90MP0005167_abnormal_blood-brain_barrier0.71408217
91MP0002086_abnormal_extraembryonic_tissu0.70945565
92MP0005376_homeostasis/metabolism_phenot0.69964065
93MP0005647_abnormal_sex_gland0.69954260
94MP0001324_abnormal_eye_pigmentation0.69756506
95MP0004883_abnormal_blood_vessel0.68673326
96MP0008873_increased_physiological_sensi0.68288278
97MP0005464_abnormal_platelet_physiology0.67984657
98MP0002877_abnormal_melanocyte_morpholog0.66904667
99MP0009785_altered_susceptibility_to0.65303696
100MP0005621_abnormal_cell_physiology0.65259264

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.75473578
2T lymphocytopenia (HP:0005403)4.62097927
3Abnormality of T cell number (HP:0011839)4.14160059
4Papillary thyroid carcinoma (HP:0002895)3.93268773
5Thyroiditis (HP:0100646)3.35338357
6Abnormality of the fingertips (HP:0001211)3.17785569
7Colitis (HP:0002583)3.07472680
8Optic neuritis (HP:0100653)3.06483789
9Retrobulbar optic neuritis (HP:0100654)3.06483789
10Subacute progressive viral hepatitis (HP:0006572)3.06373010
11IgA deficiency (HP:0002720)3.04648338
12Abnormality of T cells (HP:0002843)3.04493970
13Abnormality of eosinophils (HP:0001879)3.00593551
14Recurrent bacterial skin infections (HP:0005406)2.97849807
15Stomach cancer (HP:0012126)2.97591842
16Fair hair (HP:0002286)2.91630816
17Abnormality of pyrimidine metabolism (HP:0004353)2.83625275
18Submucous cleft hard palate (HP:0000176)2.80144266
19IgM deficiency (HP:0002850)2.75256995
20Arterial thrombosis (HP:0004420)2.75106732
21Homocystinuria (HP:0002156)2.74831778
22Abnormality of homocysteine metabolism (HP:0010919)2.74831778
23IgG deficiency (HP:0004315)2.71460009
24Volvulus (HP:0002580)2.68446695
25Fatigue (HP:0012378)2.67067978
26Prominent nose (HP:0000448)2.64755754
27Recurrent fungal infections (HP:0002841)2.64540017
28Abnormality of the columella (HP:0009929)2.63026184
29Generalized hypopigmentation of hair (HP:0011358)2.59915337
30Acute myeloid leukemia (HP:0004808)2.59412478
31Eosinophilia (HP:0001880)2.57093806
32Elevated erythrocyte sedimentation rate (HP:0003565)2.56049864
33Recurrent abscess formation (HP:0002722)2.52256903
34Gastrointestinal infarctions (HP:0005244)2.51110593
35Myositis (HP:0100614)2.50814564
36Abnormality of the nasal septum (HP:0000419)2.48770564
37Granulocytopenia (HP:0001913)2.48658355
38Thyroid carcinoma (HP:0002890)2.45919958
39Orchitis (HP:0100796)2.45188231
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.38785757
41Severe combined immunodeficiency (HP:0004430)2.36787673
42Clumsiness (HP:0002312)2.35854718
43Encephalitis (HP:0002383)2.34976746
44Inflammation of the large intestine (HP:0002037)2.34665280
45Chronic mucocutaneous candidiasis (HP:0002728)2.34079606
46Recurrent cutaneous fungal infections (HP:0011370)2.34079606
47Recurrent viral infections (HP:0004429)2.32980697
48Viral hepatitis (HP:0006562)2.29185952
49Gaze-evoked nystagmus (HP:0000640)2.27549306
50Acute hepatic failure (HP:0006554)2.27439930
51Abnormality of chromosome stability (HP:0003220)2.27199505
52Leukocytosis (HP:0001974)2.26121828
53Dislocated radial head (HP:0003083)2.24834626
54Glucose intolerance (HP:0000833)2.22037728
55Hypoplasia of the thymus (HP:0000778)2.21589287
56Spontaneous hematomas (HP:0007420)2.20850687
57Abnormality of the radial head (HP:0003995)2.20451486
58Anorexia (HP:0002039)2.18481385
59Conjunctival telangiectasia (HP:0000524)2.17119992
60Keratoconjunctivitis (HP:0001096)2.11990160
61Blue irides (HP:0000635)2.10266710
62Stomatitis (HP:0010280)2.08275007
63Neoplasm of the tracheobronchial system (HP:0100552)2.07298771
64Micronodular cirrhosis (HP:0001413)2.06904338
65Gingival bleeding (HP:0000225)2.05790493
66Abnormality of T cell physiology (HP:0011840)2.05242570
67Slow saccadic eye movements (HP:0000514)2.05170086
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03768353
69Keratoconjunctivitis sicca (HP:0001097)2.03113430
70Tented upper lip vermilion (HP:0010804)2.00666283
71Clubbing of toes (HP:0100760)1.98371705
72Sandal gap (HP:0001852)1.98245786
73Gastrointestinal inflammation (HP:0004386)1.98222039
74Recurrent skin infections (HP:0001581)1.95767379
75Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95256995
76Oligodactyly (hands) (HP:0001180)1.94285185
77Abnormality of the labia majora (HP:0012881)1.89408205
78Recurrent bronchitis (HP:0002837)1.89265108
79Abnormal glucose tolerance (HP:0001952)1.88560261
80Panhypogammaglobulinemia (HP:0003139)1.86212986
81Hematochezia (HP:0002573)1.84846754
82Cutis marmorata (HP:0000965)1.83812139
83Absent speech (HP:0001344)1.82114643
84Abnormality of alanine metabolism (HP:0010916)1.79900967
85Hyperalaninemia (HP:0003348)1.79900967
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79900967
87Chromsome breakage (HP:0040012)1.78448737
88Portal hypertension (HP:0001409)1.78066929
89Attenuation of retinal blood vessels (HP:0007843)1.77932964
90Birth length less than 3rd percentile (HP:0003561)1.77444670
91Constricted visual fields (HP:0001133)1.77015393
92Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.76600874
93Esophageal varix (HP:0002040)1.76286909
94Premature graying of hair (HP:0002216)1.75658526
95Long eyelashes (HP:0000527)1.74960594
96Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74687015
97Protruding tongue (HP:0010808)1.73158759
98Chronic hepatic failure (HP:0100626)1.72353810
99White forelock (HP:0002211)1.69889757
100Autoimmune hemolytic anemia (HP:0001890)1.69570374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.15339076
2MAP4K23.59961836
3FRK3.53917473
4BLK3.27441654
5ACVR1B3.26514317
6JAK32.44526756
7TXK2.26550587
8PIK3CG2.26405157
9AKT32.23540896
10GRK61.95433102
11FGR1.95400302
12MAP2K31.92872681
13PDK21.69985339
14SGK21.62141464
15TEC1.54658524
16MAP4K11.53187367
17ZAK1.50307420
18PIM11.45118289
19BTK1.44310384
20NEK61.41997773
21BRD41.38954886
22MAP3K71.37978994
23FES1.36698071
24MARK31.36530461
25STK41.35097809
26MELK1.34860443
27WNK11.34632807
28BMPR1B1.33956629
29BRSK21.30961962
30CAMKK21.29979880
31STK38L1.24557446
32SYK1.23206146
33MAP3K31.21381092
34PTK2B1.20712646
35ITK1.18727678
36RPS6KB21.17407767
37IKBKE1.17267209
38TLK11.16994285
39CDK121.16017078
40RAF11.12449542
41TRPM71.12407900
42SGK31.08417051
43STK381.05676788
44SGK4940.99562519
45SGK2230.99562519
46MARK20.99033916
47JAK10.98383822
48HCK0.97853541
49NUAK10.97556290
50CDK30.96621163
51MAPK110.93068104
52IKBKB0.88021263
53CAMK40.83280763
54MAP3K140.82010729
55PRKAA20.81346137
56LCK0.79418333
57BMPR20.76339645
58LYN0.72748200
59EIF2AK30.72468375
60STK100.69628540
61STK110.68817448
62CAMK1D0.68279751
63ZAP700.65830000
64NLK0.62338284
65KIT0.61840828
66CAMK10.60925101
67MTOR0.60825246
68OBSCN0.59735784
69CDK60.58484774
70JAK20.57286163
71EIF2AK10.56497834
72SGK10.54950648
73CDK40.54550772
74FGFR30.53074233
75EGFR0.52683714
76IRAK40.52680198
77CSK0.51121836
78CAMK1G0.48915555
79CHUK0.48376858
80PLK20.46366323
81MST40.46118614
82TGFBR20.44214068
83NEK90.43384325
84ADRBK10.42008211
85ERBB30.41596791
86TYK20.41487708
87PRKAA10.41103524
88MAP3K60.40955076
89OXSR10.40885215
90PDK10.40290539
91MATK0.40284455
92RPS6KA50.39296167
93RPS6KB10.37782273
94PIK3CA0.34339160
95PRKCQ0.33025566
96ATR0.32913124
97MAP3K20.32097707
98MAP2K20.31649830
99ERBB20.31320477
100MAP2K10.31013811

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053222.83023041
2Non-homologous end-joining_Homo sapiens_hsa034502.45633035
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.03646304
4NF-kappa B signaling pathway_Homo sapiens_hsa040641.90305204
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.89638133
6B cell receptor signaling pathway_Homo sapiens_hsa046621.88860893
7Non-small cell lung cancer_Homo sapiens_hsa052231.86081472
8T cell receptor signaling pathway_Homo sapiens_hsa046601.82799655
9Jak-STAT signaling pathway_Homo sapiens_hsa046301.80328013
10Primary immunodeficiency_Homo sapiens_hsa053401.77043666
11Acute myeloid leukemia_Homo sapiens_hsa052211.71365226
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69893144
13Alcoholism_Homo sapiens_hsa050341.68578575
14Viral carcinogenesis_Homo sapiens_hsa052031.67373507
15Regulation of autophagy_Homo sapiens_hsa041401.66078135
16FoxO signaling pathway_Homo sapiens_hsa040681.63951084
17Fanconi anemia pathway_Homo sapiens_hsa034601.62979434
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58296124
19Lysine degradation_Homo sapiens_hsa003101.57693753
20Measles_Homo sapiens_hsa051621.57047972
21Osteoclast differentiation_Homo sapiens_hsa043801.52872165
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.47438636
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43468094
24Leishmaniasis_Homo sapiens_hsa051401.39034431
25Dorso-ventral axis formation_Homo sapiens_hsa043201.34134365
26Circadian rhythm_Homo sapiens_hsa047101.33175155
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.27935196
28Nitrogen metabolism_Homo sapiens_hsa009101.27475823
29Graft-versus-host disease_Homo sapiens_hsa053321.25826115
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21919755
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20893028
32Inositol phosphate metabolism_Homo sapiens_hsa005621.20822583
33Apoptosis_Homo sapiens_hsa042101.20796158
34Endometrial cancer_Homo sapiens_hsa052131.20466609
35TNF signaling pathway_Homo sapiens_hsa046681.16057677
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12759569
37Platelet activation_Homo sapiens_hsa046111.10731364
38Hepatitis B_Homo sapiens_hsa051611.09372684
39Tuberculosis_Homo sapiens_hsa051521.06376500
40Toxoplasmosis_Homo sapiens_hsa051451.02657220
41Autoimmune thyroid disease_Homo sapiens_hsa053201.02235450
42Herpes simplex infection_Homo sapiens_hsa051681.01523421
43Thyroid cancer_Homo sapiens_hsa052161.00941075
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00229598
45Allograft rejection_Homo sapiens_hsa053300.99334910
46MicroRNAs in cancer_Homo sapiens_hsa052060.97729806
47Basal transcription factors_Homo sapiens_hsa030220.97660002
48Influenza A_Homo sapiens_hsa051640.97005204
49Small cell lung cancer_Homo sapiens_hsa052220.95777528
50Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94879902
51Legionellosis_Homo sapiens_hsa051340.93738214
52RNA degradation_Homo sapiens_hsa030180.92770829
53Chronic myeloid leukemia_Homo sapiens_hsa052200.92463357
54mTOR signaling pathway_Homo sapiens_hsa041500.92436765
55Pancreatic cancer_Homo sapiens_hsa052120.92324729
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91277230
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.90578841
58Staphylococcus aureus infection_Homo sapiens_hsa051500.89105064
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87610627
60Hematopoietic cell lineage_Homo sapiens_hsa046400.87336540
61Prolactin signaling pathway_Homo sapiens_hsa049170.87027684
62Prostate cancer_Homo sapiens_hsa052150.86391854
63TGF-beta signaling pathway_Homo sapiens_hsa043500.83476731
64Homologous recombination_Homo sapiens_hsa034400.80022976
65Choline metabolism in cancer_Homo sapiens_hsa052310.77473906
66Insulin resistance_Homo sapiens_hsa049310.77238677
67Olfactory transduction_Homo sapiens_hsa047400.75664136
68Chemokine signaling pathway_Homo sapiens_hsa040620.75657713
69Ether lipid metabolism_Homo sapiens_hsa005650.74044876
70One carbon pool by folate_Homo sapiens_hsa006700.71813617
71ABC transporters_Homo sapiens_hsa020100.71721216
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71470379
73Arginine biosynthesis_Homo sapiens_hsa002200.71380866
74Colorectal cancer_Homo sapiens_hsa052100.69024216
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68278979
76Malaria_Homo sapiens_hsa051440.67310212
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66974078
78Hepatitis C_Homo sapiens_hsa051600.64230535
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.59556125
80p53 signaling pathway_Homo sapiens_hsa041150.58387613
81Viral myocarditis_Homo sapiens_hsa054160.58184708
82HTLV-I infection_Homo sapiens_hsa051660.56753528
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53125074
84Taste transduction_Homo sapiens_hsa047420.50406697
85Glycerolipid metabolism_Homo sapiens_hsa005610.50364460
86Cell cycle_Homo sapiens_hsa041100.50295224
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.49552302
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46026929
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45436963
90Linoleic acid metabolism_Homo sapiens_hsa005910.45375525
91Epstein-Barr virus infection_Homo sapiens_hsa051690.45153748
92GnRH signaling pathway_Homo sapiens_hsa049120.44042808
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42995341
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42580698
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.40500810
96Fatty acid biosynthesis_Homo sapiens_hsa000610.40141100
97ErbB signaling pathway_Homo sapiens_hsa040120.39645499
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39633226
99mRNA surveillance pathway_Homo sapiens_hsa030150.39520019
100Type II diabetes mellitus_Homo sapiens_hsa049300.37754196

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