ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	6.56512576
2	proteasome assembly (GO:0043248)	6.25572152
3	regulation of mitochondrial translation (GO:0070129)	5.42190510
4	ribosomal large subunit biogenesis (GO:0042273)	5.31757405
5	maturation of SSU-rRNA (GO:0030490)	4.89464859
6	DNA replication checkpoint (GO:0000076)	4.87050834
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.85195444
8	regulation of cellular respiration (GO:0043457)	4.77939812
9	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	4.64223102
10	protein targeting to mitochondrion (GO:0006626)	4.50990740
11	ribosomal small subunit assembly (GO:0000028)	4.50553099
12	CENP-A containing nucleosome assembly (GO:0034080)	4.47064369
13	ATP synthesis coupled proton transport (GO:0015986)	4.38637679
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.38637679
15	chromatin remodeling at centromere (GO:0031055)	4.38214434
16	DNA deamination (GO:0045006)	4.36040899
17	pseudouridine synthesis (GO:0001522)	4.31355956
18	ribosome assembly (GO:0042255)	4.21417278
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.17607373
20	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.07558106
21	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	4.05567162
22	establishment of protein localization to mitochondrion (GO:0072655)	3.97483708
23	histone exchange (GO:0043486)	3.91730730
24	ribonucleoprotein complex disassembly (GO:0032988)	3.89436611
25	protein localization to mitochondrion (GO:0070585)	3.87651292
26	rRNA modification (GO:0000154)	3.86655078
27	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.82960889
28	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.74604036
29	termination of RNA polymerase III transcription (GO:0006386)	3.74604036
30	rRNA processing (GO:0006364)	3.73690275
31	protein deneddylation (GO:0000338)	3.72978685
32	response to nitrosative stress (GO:0051409)	3.72636845
33	ribosomal small subunit biogenesis (GO:0042274)	3.69095069
34	regulation of oxidative phosphorylation (GO:0002082)	3.65892902
35	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.65505068
36	spliceosomal snRNP assembly (GO:0000387)	3.65249075
37	cullin deneddylation (GO:0010388)	3.64169229
38	rRNA metabolic process (GO:0016072)	3.59798793
39	negative regulation of execution phase of apoptosis (GO:1900118)	3.54207426
40	DNA damage response, detection of DNA damage (GO:0042769)	3.52873665
41	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.52299859
42	blastocyst development (GO:0001824)	3.49262622
43	male meiosis I (GO:0007141)	3.48500327
44	respiratory electron transport chain (GO:0022904)	3.46169170
45	inner mitochondrial membrane organization (GO:0007007)	3.43445457
46	viral transcription (GO:0019083)	3.41321542
47	electron transport chain (GO:0022900)	3.38708218
48	translation (GO:0006412)	3.38267044
49	ribonucleoprotein complex biogenesis (GO:0022613)	3.37648713
50	DNA replication-independent nucleosome assembly (GO:0006336)	3.36025819
51	DNA replication-independent nucleosome organization (GO:0034724)	3.36025819
52	translational termination (GO:0006415)	3.34069915
53	organelle disassembly (GO:1903008)	3.34058149
54	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.29854684
55	NADH dehydrogenase complex assembly (GO:0010257)	3.29854684
56	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.29854684
57	meiosis I (GO:0007127)	3.27229006
58	DNA replication-dependent nucleosome assembly (GO:0006335)	3.23812942
59	DNA replication-dependent nucleosome organization (GO:0034723)	3.23812942
60	positive regulation of prostaglandin secretion (GO:0032308)	3.22474288
61	mitochondrial RNA metabolic process (GO:0000959)	3.20391360
62	melanin biosynthetic process (GO:0042438)	3.19659496
63	iron-sulfur cluster assembly (GO:0016226)	3.17038416
64	metallo-sulfur cluster assembly (GO:0031163)	3.17038416
65	rRNA methylation (GO:0031167)	3.16706350
66	protein neddylation (GO:0045116)	3.16604306
67	formation of translation preinitiation complex (GO:0001731)	3.15005946
68	cellular component biogenesis (GO:0044085)	3.14778970
69	translational initiation (GO:0006413)	3.14581072
70	transcription from mitochondrial promoter (GO:0006390)	3.10357030
71	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.03436398
72	mitotic metaphase plate congression (GO:0007080)	3.02277760
73	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.99380448
74	mitochondrial respiratory chain complex assembly (GO:0033108)	2.97797531
75	secondary metabolite biosynthetic process (GO:0044550)	2.97493607
76	cotranslational protein targeting to membrane (GO:0006613)	2.96888783
77	translational elongation (GO:0006414)	2.96770070
78	cellular response to oxygen radical (GO:0071450)	2.95996421
79	removal of superoxide radicals (GO:0019430)	2.95996421
80	cellular response to superoxide (GO:0071451)	2.95996421
81	protein targeting to ER (GO:0045047)	2.95074489
82	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.94720318
83	mitochondrial transport (GO:0006839)	2.93086423
84	ncRNA metabolic process (GO:0034660)	2.92853843
85	piRNA metabolic process (GO:0034587)	2.91198960
86	ncRNA processing (GO:0034470)	2.88484647
87	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.88120767
88	protein complex biogenesis (GO:0070271)	2.85807768
89	tRNA processing (GO:0008033)	2.85728799
90	protein localization to endoplasmic reticulum (GO:0070972)	2.82513031
91	GTP biosynthetic process (GO:0006183)	2.82347137
92	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.82033511
93	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.79792115
94	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.77757728
95	mitotic sister chromatid segregation (GO:0000070)	2.77409196
96	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.74582015
97	regulation of cellular amino acid metabolic process (GO:0006521)	2.73024316
98	regulation of gene expression by genetic imprinting (GO:0006349)	2.72540582
99	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.67118702
100	tRNA metabolic process (GO:0006399)	2.66482306

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.76064472
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.15838684
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.11795466
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.94796928
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.93371908
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.77668859
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.72829697
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.69177528
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.58354855
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.56618418
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.45410610
12	E2F7_22180533_ChIP-Seq_HELA_Human	3.17811197
13	THAP11_20581084_ChIP-Seq_MESCs_Mouse	3.01234863
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.95998433
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.75052342
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.64323315
17	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.58236778
18	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.43534043
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.31773440
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.28335050
21	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.27347820
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.25943746
23	FOXP3_21729870_ChIP-Seq_TREG_Human	2.25668292
24	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.25528157
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.17037265
26	VDR_23849224_ChIP-Seq_CD4+_Human	2.13973864
27	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.13318360
28	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.09948509
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.93554988
30	GABP_19822575_ChIP-Seq_HepG2_Human	1.91366173
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.89025170
32	DCP1A_22483619_ChIP-Seq_HELA_Human	1.82707800
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.81082829
34	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.78695138
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.78114230
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73817387
37	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67445156
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.65071360
39	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.54748006
40	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.52037622
41	XRN2_22483619_ChIP-Seq_HELA_Human	1.50356766
42	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.47133735
43	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.46909789
44	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.45168320
45	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.45011777
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.41600633
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.36288943
48	AR_21909140_ChIP-Seq_LNCAP_Human	1.34656811
49	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.29747895
50	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29261880
51	KDM5A_27292631_Chip-Seq_BREAST_Human	1.26423634
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.23253967
53	ZNF274_21170338_ChIP-Seq_K562_Hela	1.21875025
54	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.18996188
55	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.17607326
56	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.15144518
57	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.13576773
58	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.13211621
59	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.10714931
60	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.10624766
61	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.10519224
62	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.10287127
63	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.09581889
64	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.05666325
65	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04710778
66	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.04457357
67	VDR_22108803_ChIP-Seq_LS180_Human	1.03560573
68	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.03525708
69	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.01731691
70	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.00201500
71	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.99023103
72	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.98961551
73	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98304366
74	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.98304366
75	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.97451968
76	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.95752778
77	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.94358614
78	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.92375249
79	TP53_22573176_ChIP-Seq_HFKS_Human	0.90664796
80	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.87286036
81	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.87083471
82	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.86187252
83	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.83383793
84	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.82033313
85	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.81526887
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.81208174
87	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.80805348
88	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.79992109
89	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.79113248
90	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.78933744
91	NCOR_22424771_ChIP-Seq_293T_Human	0.77923913
92	ELF5_23300383_ChIP-Seq_T47D_Human	0.77295544
93	IGF1R_20145208_ChIP-Seq_DFB_Human	0.76310245
94	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.73562843
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.72430281
96	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.71980041
97	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.71595628
98	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.68679434
99	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.68595097
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.68250138

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	4.20814778
2	MP0006292_abnormal_olfactory_placode	4.08428646
3	MP0003136_yellow_coat_color	3.34341917
4	MP0003693_abnormal_embryo_hatching	3.25786809
5	MP0004957_abnormal_blastocyst_morpholog	2.94164139
6	MP0003806_abnormal_nucleotide_metabolis	2.77325826
7	MP0003878_abnormal_ear_physiology	2.66617640
8	MP0005377_hearing/vestibular/ear_phenot	2.66617640
9	MP0009053_abnormal_anal_canal	2.63629437
10	MP0002102_abnormal_ear_morphology	2.54464827
11	MP0005187_abnormal_penis_morphology	2.53560627
12	MP0001986_abnormal_taste_sensitivity	2.33986066
13	MP0008872_abnormal_physiological_respon	2.31447477
14	MP0005408_hypopigmentation	2.30117532
15	MP0005084_abnormal_gallbladder_morpholo	2.29240122
16	MP0003111_abnormal_nucleus_morphology	2.24322215
17	MP0003186_abnormal_redox_activity	2.14601809
18	MP0009379_abnormal_foot_pigmentation	2.13307226
19	MP0003718_maternal_effect	2.10287628
20	MP0001293_anophthalmia	2.09522160
21	MP0010094_abnormal_chromosome_stability	2.08263638
22	MP0008875_abnormal_xenobiotic_pharmacok	2.05423314
23	MP0003077_abnormal_cell_cycle	2.00045440
24	MP0002938_white_spotting	1.96062428
25	MP0000647_abnormal_sebaceous_gland	1.93823490
26	MP0002160_abnormal_reproductive_system	1.93599296
27	MP0006036_abnormal_mitochondrial_physio	1.83034619
28	MP0008058_abnormal_DNA_repair	1.80654328
29	MP0001485_abnormal_pinna_reflex	1.77278998
30	MP0002095_abnormal_skin_pigmentation	1.76345913
31	MP0004885_abnormal_endolymph	1.73732997
32	MP0005670_abnormal_white_adipose	1.63439875
33	MP0003937_abnormal_limbs/digits/tail_de	1.56334418
34	MP0005671_abnormal_response_to	1.53400350
35	MP0008877_abnormal_DNA_methylation	1.53368811
36	MP0001968_abnormal_touch/_nociception	1.45093337
37	MP0003879_abnormal_hair_cell	1.38030936
38	MP0005410_abnormal_fertilization	1.36636283
39	MP0003567_abnormal_fetal_cardiomyocyte	1.35133835
40	MP0000015_abnormal_ear_pigmentation	1.34667485
41	MP0002736_abnormal_nociception_after	1.33855856
42	MP0003283_abnormal_digestive_organ	1.31241181
43	MP0005083_abnormal_biliary_tract	1.29296296
44	MP0003890_abnormal_embryonic-extraembry	1.29155489
45	MP0009333_abnormal_splenocyte_physiolog	1.27923248
46	MP0001324_abnormal_eye_pigmentation	1.26078255
47	MP0000371_diluted_coat_color	1.23498793
48	MP0005389_reproductive_system_phenotype	1.23230083
49	MP0005174_abnormal_tail_pigmentation	1.20095408
50	MP0002210_abnormal_sex_determination	1.19534092
51	MP0005360_urolithiasis	1.13617234
52	MP0003195_calcinosis	1.11462030
53	MP0002796_impaired_skin_barrier	1.08862108
54	MP0006035_abnormal_mitochondrial_morpho	1.05550782
55	MP0008789_abnormal_olfactory_epithelium	1.04774015
56	MP0001929_abnormal_gametogenesis	1.02185786
57	MP0005636_abnormal_mineral_homeostasis	1.01985443
58	MP0003646_muscle_fatigue	0.99322650
59	MP0001697_abnormal_embryo_size	0.99151024
60	MP0008932_abnormal_embryonic_tissue	0.99008993
61	MP0000427_abnormal_hair_cycle	0.98977203
62	MP0005451_abnormal_body_composition	0.98437465
63	MP0005171_absent_coat_pigmentation	0.98433305
64	MP0000049_abnormal_middle_ear	0.95149859
65	MP0008057_abnormal_DNA_replication	0.92573159
66	MP0002837_dystrophic_cardiac_calcinosis	0.91692672
67	MP0004145_abnormal_muscle_electrophysio	0.90041502
68	MP0002735_abnormal_chemical_nociception	0.89839620
69	MP0005075_abnormal_melanosome_morpholog	0.89812799
70	MP0001730_embryonic_growth_arrest	0.89704992
71	MP0005551_abnormal_eye_electrophysiolog	0.86635164
72	MP0003698_abnormal_male_reproductive	0.85245061
73	MP0000653_abnormal_sex_gland	0.85098068
74	MP0006072_abnormal_retinal_apoptosis	0.84087886
75	MP0001145_abnormal_male_reproductive	0.82643893
76	MP0002085_abnormal_embryonic_tissue	0.81675355
77	MP0005395_other_phenotype	0.81610230
78	MP0004215_abnormal_myocardial_fiber	0.80845355
79	MP0000579_abnormal_nail_morphology	0.80128779
80	MP0001119_abnormal_female_reproductive	0.80037098
81	MP0003123_paternal_imprinting	0.79719802
82	MP0008873_increased_physiological_sensi	0.79228580
83	MP0001529_abnormal_vocalization	0.77450726
84	MP0005380_embryogenesis_phenotype	0.74906251
85	MP0001672_abnormal_embryogenesis/_devel	0.74906251
86	MP0000631_abnormal_neuroendocrine_gland	0.71620509
87	MP0001963_abnormal_hearing_physiology	0.69358826
88	MP0002877_abnormal_melanocyte_morpholog	0.69085017
89	MP0003786_premature_aging	0.69014439
90	MP0003936_abnormal_reproductive_system	0.68566438
91	MP0008770_decreased_survivor_rate	0.67646554
92	MP0003252_abnormal_bile_duct	0.65379236
93	MP0001905_abnormal_dopamine_level	0.63712224
94	MP0000313_abnormal_cell_death	0.63543642
95	MP0005266_abnormal_metabolism	0.63417366
96	MP0004142_abnormal_muscle_tone	0.63343315
97	MP0003137_abnormal_impulse_conducting	0.62799415
98	MP0005332_abnormal_amino_acid	0.61722652
99	MP0000026_abnormal_inner_ear	0.59581373
100	MP0004924_abnormal_behavior	0.59497862

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	5.37110855
2	Abnormality of the phalanges of the hallux (HP:0010057)	5.06022723
3	Oral leukoplakia (HP:0002745)	4.39457427
4	Short middle phalanx of the 5th finger (HP:0004220)	4.36867590
5	Abnormality of the fetal cardiovascular system (HP:0010948)	4.36327242
6	Abnormal umbilical cord blood vessels (HP:0011403)	4.36327242
7	Single umbilical artery (HP:0001195)	4.36327242
8	Broad distal phalanx of finger (HP:0009836)	3.75613273
9	Esophageal atresia (HP:0002032)	3.73806634
10	Acute necrotizing encephalopathy (HP:0006965)	3.40941348
11	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	3.30081951
12	Hyperalaninemia (HP:0003348)	3.20066374
13	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.20066374
14	Abnormality of alanine metabolism (HP:0010916)	3.20066374
15	Abnormality of the middle phalanges of the toes (HP:0010183)	3.11561868
16	Ectopic kidney (HP:0000086)	3.09391767
17	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	3.00307883
18	Methylmalonic acidemia (HP:0002912)	2.97037719
19	Abnormality of homocysteine metabolism (HP:0010919)	2.96851010
20	Homocystinuria (HP:0002156)	2.96851010
21	Mitochondrial inheritance (HP:0001427)	2.96584604
22	Abnormality of the umbilical cord (HP:0010881)	2.91191538
23	Methylmalonic aciduria (HP:0012120)	2.90903933
24	Abnormal mitochondria in muscle tissue (HP:0008316)	2.90784450
25	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.87492378
26	Absent radius (HP:0003974)	2.87243542
27	Increased CSF lactate (HP:0002490)	2.84415301
28	Progressive macrocephaly (HP:0004481)	2.80148284
29	Acute encephalopathy (HP:0006846)	2.76728764
30	Aplasia involving forearm bones (HP:0009822)	2.76332083
31	Absent forearm bone (HP:0003953)	2.76332083
32	Leukodystrophy (HP:0002415)	2.72762642
33	Birth length less than 3rd percentile (HP:0003561)	2.66985571
34	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.65013860
35	Aplasia/Hypoplasia of the macula (HP:0008059)	2.64656015
36	Occipital encephalocele (HP:0002085)	2.48803785
37	Renal dysplasia (HP:0000110)	2.47789364
38	Abnormality of the 4th metacarpal (HP:0010012)	2.46763063
39	Increased hepatocellular lipid droplets (HP:0006565)	2.46671158
40	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.46166432
41	Triphalangeal thumb (HP:0001199)	2.45885540
42	Abnormal number of erythroid precursors (HP:0012131)	2.36337388
43	Microretrognathia (HP:0000308)	2.34302691
44	Absent phalangeal crease (HP:0006109)	2.32270203
45	Hepatic necrosis (HP:0002605)	2.29219427
46	Gastrointestinal atresia (HP:0002589)	2.27676940
47	Increased serum lactate (HP:0002151)	2.24363181
48	Hepatocellular necrosis (HP:0001404)	2.24243569
49	Anencephaly (HP:0002323)	2.21468175
50	Tongue fasciculations (HP:0001308)	2.21190601
51	Premature graying of hair (HP:0002216)	2.19969084
52	Macrocytic anemia (HP:0001972)	2.19140579
53	Abnormality of the distal phalanx of the thumb (HP:0009617)	2.17842927
54	Reticulocytopenia (HP:0001896)	2.16824410
55	Type II lissencephaly (HP:0007260)	2.16198799
56	Abnormal ventriculo-arterial connection (HP:0011563)	2.14734234
57	Transposition of the great arteries (HP:0001669)	2.14734234
58	Abnormal connection of the cardiac segments (HP:0011545)	2.14734234
59	Tracheal stenosis (HP:0002777)	2.11505887
60	Glycosuria (HP:0003076)	2.11197825
61	Abnormality of urine glucose concentration (HP:0011016)	2.11197825
62	Lipid accumulation in hepatocytes (HP:0006561)	2.10969329
63	Partial duplication of thumb phalanx (HP:0009944)	2.10409945
64	Abnormality of cells of the erythroid lineage (HP:0012130)	2.09094322
65	Short thumb (HP:0009778)	2.07874091
66	Abnormality of the distal phalanges of the toes (HP:0010182)	2.06069371
67	Hypoplasia of the radius (HP:0002984)	2.06013396
68	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.05673165
69	Hypoplasia of the fovea (HP:0007750)	2.05673165
70	Pancytopenia (HP:0001876)	2.03458588
71	Abnormal finger flexion creases (HP:0006143)	2.02853712
72	Pendular nystagmus (HP:0012043)	2.00940577
73	Cerebral hypomyelination (HP:0006808)	2.00397582
74	Preaxial foot polydactyly (HP:0001841)	1.99714762
75	Abnormal auditory evoked potentials (HP:0006958)	1.99465808
76	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.95443810
77	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.95443810
78	Abnormality of the labia minora (HP:0012880)	1.94827478
79	CNS hypomyelination (HP:0003429)	1.94790516
80	Short 5th finger (HP:0009237)	1.94078004
81	Cerebellar dysplasia (HP:0007033)	1.94014641
82	Abnormality of methionine metabolism (HP:0010901)	1.93051387
83	Increased intramyocellular lipid droplets (HP:0012240)	1.93015342
84	Cerebral edema (HP:0002181)	1.92134645
85	Abnormal number of incisors (HP:0011064)	1.90188475
86	Increased serum pyruvate (HP:0003542)	1.89119802
87	Hyperglycinemia (HP:0002154)	1.88892750
88	Abnormality of the fovea (HP:0000493)	1.86757755
89	Hypomagnesemia (HP:0002917)	1.84692371
90	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.84565595
91	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.84285567
92	Palpitations (HP:0001962)	1.83699252
93	Muscle fibrillation (HP:0010546)	1.83338640
94	Lactic acidosis (HP:0003128)	1.81686664
95	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.81222608
96	Type I transferrin isoform profile (HP:0003642)	1.80673441
97	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.79880696
98	Anal atresia (HP:0002023)	1.79520500
99	Tetany (HP:0001281)	1.78265057
100	Duplication of thumb phalanx (HP:0009942)	1.78178714

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	5.51629604
2	STK16	5.19744544
3	PBK	4.44336120
4	ZAK	3.62825177
5	CDC7	3.11794826
6	MST4	2.97296916
7	NEK1	2.83790645
8	BUB1	2.82319436
9	PDK2	2.63858040
10	EIF2AK1	2.60081759
11	SRPK1	2.04185291
12	MAP3K4	1.98395434
13	EIF2AK3	1.93740067
14	MAP2K7	1.92545791
15	NME2	1.85628943
16	OXSR1	1.82914316
17	ADRBK2	1.71016328
18	TRIM28	1.60894919
19	NUAK1	1.52545655
20	NME1	1.50625616
21	PLK3	1.45494412
22	MKNK2	1.40203831
23	FRK	1.37211600
24	CDK19	1.36975954
25	STK39	1.36816580
26	WEE1	1.33217194
27	PLK1	1.32277513
28	TTK	1.26456635
29	CLK1	1.15131490
30	GRK1	1.09437653
31	WNK3	1.09409663
32	MKNK1	1.05794284
33	MARK3	1.00563578
34	PLK2	0.97748393
35	STK4	0.95326430
36	AURKB	0.93658501
37	RPS6KA5	0.93087294
38	VRK1	0.92259808
39	PRKCI	0.88120648
40	ABL2	0.87363400
41	BCKDK	0.86763421
42	VRK2	0.85945568
43	AURKA	0.85007870
44	RPS6KB2	0.83640675
45	WNK4	0.81196008
46	KDR	0.78341352
47	BMPR2	0.78301624
48	STK3	0.76122308
49	TSSK6	0.69336890
50	AKT2	0.68212794
51	RPS6KA4	0.67198531
52	CSNK1G3	0.65568385
53	NEK2	0.63578272
54	IRAK3	0.62353005
55	GRK6	0.60934347
56	PLK4	0.60245513
57	ILK	0.57888724
58	AKT3	0.54967364
59	CSNK2A1	0.54322668
60	PIM1	0.52752816
61	CHEK2	0.51097923
62	CAMK2D	0.49960087
63	CAMK2G	0.49897428
64	ATR	0.49653692
65	ADRBK1	0.49300670
66	PASK	0.49040588
67	LATS1	0.48941172
68	CSNK1G1	0.48571577
69	CSNK2A2	0.48128752
70	CSNK1G2	0.46785468
71	DAPK3	0.46339326
72	CAMK2A	0.43384441
73	MAP2K2	0.43320110
74	EPHA2	0.42958246
75	DYRK2	0.41119607
76	CHEK1	0.41018184
77	CDK7	0.40931011
78	TAOK3	0.38415544
79	BMPR1B	0.38268482
80	EIF2AK2	0.38216899
81	CSNK1A1	0.37979497
82	TNIK	0.37287392
83	CAMK2B	0.34334206
84	CSNK1A1L	0.33830347
85	ALK	0.33031515
86	ERBB3	0.31418457
87	EGFR	0.30045034
88	ATM	0.29928137
89	FGR	0.29655518
90	ERBB4	0.29519510
91	MAP3K8	0.29319093
92	PRKCG	0.29246391
93	MAP2K4	0.28198359
94	CSNK1E	0.28131928
95	TXK	0.26849007
96	MAPKAPK3	0.26637116
97	PINK1	0.25644237
98	INSRR	0.25093405
99	PRKCE	0.23262656
100	MUSK	0.22744086

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.45859094
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.65622454
3	Proteasome_Homo sapiens_hsa03050	3.42614937
4	RNA polymerase_Homo sapiens_hsa03020	3.36486138
5	Parkinsons disease_Homo sapiens_hsa05012	3.28309035
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.96035103
7	Huntingtons disease_Homo sapiens_hsa05016	2.68449230
8	DNA replication_Homo sapiens_hsa03030	2.55674439
9	One carbon pool by folate_Homo sapiens_hsa00670	2.45297686
10	Spliceosome_Homo sapiens_hsa03040	2.41984194
11	Alzheimers disease_Homo sapiens_hsa05010	1.93715975
12	Mismatch repair_Homo sapiens_hsa03430	1.90659887
13	RNA transport_Homo sapiens_hsa03013	1.89531820
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.86710374
15	Homologous recombination_Homo sapiens_hsa03440	1.83517899
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.76537816
17	Base excision repair_Homo sapiens_hsa03410	1.76134035
18	Protein export_Homo sapiens_hsa03060	1.76123591
19	Basal transcription factors_Homo sapiens_hsa03022	1.76106847
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.74002082
21	RNA degradation_Homo sapiens_hsa03018	1.67507483
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.67323918
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.61564765
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.53716038
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.53356581
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52426583
27	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.52373521
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.42597698
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.35400362
30	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.35321181
31	Collecting duct acid secretion_Homo sapiens_hsa04966	1.31773696
32	Phototransduction_Homo sapiens_hsa04744	1.31289893
33	Purine metabolism_Homo sapiens_hsa00230	1.30083943
34	Sulfur relay system_Homo sapiens_hsa04122	1.29960748
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.29871536
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.24220279
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.23731771
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.23524631
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.23143023
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.21458839
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.17977896
42	Glutathione metabolism_Homo sapiens_hsa00480	1.08796061
43	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.93309075
44	Folate biosynthesis_Homo sapiens_hsa00790	0.91500405
45	Histidine metabolism_Homo sapiens_hsa00340	0.88758049
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.86057228
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.80874881
48	Caffeine metabolism_Homo sapiens_hsa00232	0.79763096
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.77721837
50	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.76194103
51	mRNA surveillance pathway_Homo sapiens_hsa03015	0.75454705
52	Metabolic pathways_Homo sapiens_hsa01100	0.73106603
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.72806914
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71357450
55	Cell cycle_Homo sapiens_hsa04110	0.71300666
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71158950
57	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.70076312
58	Propanoate metabolism_Homo sapiens_hsa00640	0.62523527
59	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.62084079
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.60302376
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58826589
62	Peroxisome_Homo sapiens_hsa04146	0.57652551
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.57375535
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56805420
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54049603
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53882167
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52701200
68	Retinol metabolism_Homo sapiens_hsa00830	0.52230519
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51570308
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.51138987
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48500583
72	Nicotine addiction_Homo sapiens_hsa05033	0.47409805
73	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.46197128
74	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.45490758
75	Fatty acid degradation_Homo sapiens_hsa00071	0.45305576
76	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44894734
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.44461493
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43863625
79	Butanoate metabolism_Homo sapiens_hsa00650	0.43314100
80	Fatty acid elongation_Homo sapiens_hsa00062	0.42172669
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.41585981
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40467257
83	p53 signaling pathway_Homo sapiens_hsa04115	0.40439482
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40001495
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.39834463
86	Regulation of autophagy_Homo sapiens_hsa04140	0.39788332
87	Serotonergic synapse_Homo sapiens_hsa04726	0.37696188
88	ABC transporters_Homo sapiens_hsa02010	0.34115566
89	Taste transduction_Homo sapiens_hsa04742	0.33148117
90	Carbon metabolism_Homo sapiens_hsa01200	0.32851084
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.31402953
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.31082581
93	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.30994681
94	Oocyte meiosis_Homo sapiens_hsa04114	0.30887223
95	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.29457813
96	Phenylalanine metabolism_Homo sapiens_hsa00360	0.28915389
97	Vibrio cholerae infection_Homo sapiens_hsa05110	0.28164177
98	Nitrogen metabolism_Homo sapiens_hsa00910	0.27653031
99	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.27449667
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.26176666

KRT18P33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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