KRT18P34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diaphragm development (GO:0060539)9.83758804
2arginine catabolic process (GO:0006527)9.56323847
3skeletal muscle organ development (GO:0060538)8.75930283
4pyrimidine nucleoside salvage (GO:0043097)8.18562836
5pyrimidine-containing compound salvage (GO:0008655)8.18562836
6cellular protein complex localization (GO:0034629)8.10194694
7positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)7.98609807
8regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)7.98479925
9negative regulation of calcium ion transport into cytosol (GO:0010523)7.81858801
10arginine metabolic process (GO:0006525)7.67421034
11negative regulation of neurotransmitter transport (GO:0051589)7.63967777
12exogenous drug catabolic process (GO:0042738)7.26430759
13pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)7.08440295
14UMP biosynthetic process (GO:0006222)7.08440295
15pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)7.08440295
16UMP metabolic process (GO:0046049)7.08440295
17negative regulation of peptidyl-threonine phosphorylation (GO:0010801)7.03365259
18negative regulation of vascular permeability (GO:0043116)6.97383001
19response to lipoprotein particle (GO:0055094)6.89066146
20negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)6.81233742
21positive regulation of guanylate cyclase activity (GO:0031284)6.06150874
223-UTR-mediated mRNA stabilization (GO:0070935)6.03695506
23positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)5.89825900
24pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)5.77251382
25nucleotide salvage (GO:0043173)5.69155206
26regulation of nuclear cell cycle DNA replication (GO:0033262)5.66433523
27negative regulation of potassium ion transport (GO:0043267)5.63403460
28regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)5.57298077
29regulation of guanylate cyclase activity (GO:0031282)5.55386248
30drug catabolic process (GO:0042737)5.53788270
31nucleoside salvage (GO:0043174)5.46757061
32protein complex localization (GO:0031503)5.40655639
33pyrimidine nucleoside monophosphate metabolic process (GO:0009129)5.33992348
34positive regulation of receptor biosynthetic process (GO:0010870)5.18006735
35regulation of neurotransmitter uptake (GO:0051580)5.16194763
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.08863176
37protein heterotrimerization (GO:0070208)5.03278704
38adenine nucleotide transport (GO:0051503)5.03175131
39activation of MAPKKK activity (GO:0000185)5.01124901
40regulation of cholesterol biosynthetic process (GO:0045540)4.99718408
41histone H3-K4 methylation (GO:0051568)4.80817341
42positive regulation of signal transduction by p53 class mediator (GO:1901798)4.75064358
43regulation of mitochondrial translation (GO:0070129)4.66414549
44regulation of stem cell maintenance (GO:2000036)4.65778776
45positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.48874103
46lateral sprouting from an epithelium (GO:0060601)4.48398454
47negative regulation of protein kinase B signaling (GO:0051898)4.46919829
48mRNA stabilization (GO:0048255)4.44887092
49RNA stabilization (GO:0043489)4.44887092
50negative regulation of macrophage differentiation (GO:0045650)4.44059920
51positive regulation of DNA-dependent DNA replication (GO:2000105)4.43752749
52nitric oxide biosynthetic process (GO:0006809)4.42001191
53negative regulation of granulocyte differentiation (GO:0030853)4.37057044
54negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.36624969
55negative regulation of T cell receptor signaling pathway (GO:0050860)4.30044023
56CTP biosynthetic process (GO:0006241)4.25772600
57CTP metabolic process (GO:0046036)4.25772600
58hypotonic response (GO:0006971)4.23609835
59regulation of mRNA catabolic process (GO:0061013)4.21775332
60chromatin silencing (GO:0006342)4.18675876
61ribosomal small subunit assembly (GO:0000028)4.17011328
62nerve growth factor signaling pathway (GO:0038180)4.13945198
63regulation of intracellular estrogen receptor signaling pathway (GO:0033146)4.07213477
64negative regulation of alcohol biosynthetic process (GO:1902931)4.04520364
65DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.02445975
66purine nucleotide transport (GO:0015865)4.01485750
67purine ribonucleotide transport (GO:0015868)3.97809786
68regulation of protein deacetylation (GO:0090311)3.96040098
69pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.92822851
70urea cycle (GO:0000050)3.89197226
71positive regulation of mRNA catabolic process (GO:0061014)3.83983208
72myoblast fusion (GO:0007520)3.83787495
73positive regulation of sodium ion transmembrane transport (GO:1902307)3.82611428
74negative regulation of potassium ion transmembrane transport (GO:1901380)3.79009109
75neurotransmitter biosynthetic process (GO:0042136)3.78706004
76positive regulation of catecholamine secretion (GO:0033605)3.77176690
77ncRNA 3-end processing (GO:0043628)3.75271608
78nitric oxide mediated signal transduction (GO:0007263)3.69626660
79regulation of cilium assembly (GO:1902017)3.69592644
80DNA damage response, signal transduction resulting in transcription (GO:0042772)3.69022966
81regulation of oxidative phosphorylation (GO:0002082)3.68273036
82pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.64437589
83urea metabolic process (GO:0019627)3.60936719
84positive regulation of cGMP biosynthetic process (GO:0030828)3.60073864
85inactivation of MAPK activity (GO:0000188)3.55293936
86positive regulation of histone acetylation (GO:0035066)3.54890386
87oogenesis (GO:0048477)3.53417884
88regulation of cell size (GO:0008361)3.49044725
89peptidyl-cysteine modification (GO:0018198)3.48064983
90pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.45473056
91regulation of cGMP biosynthetic process (GO:0030826)3.40963416
92syncytium formation by plasma membrane fusion (GO:0000768)3.40223842
93Rap protein signal transduction (GO:0032486)3.32891619
94dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.29569203
95platelet-derived growth factor receptor signaling pathway (GO:0048008)3.26612427
96regulation of synaptic vesicle transport (GO:1902803)3.26171962
97cellular response to nerve growth factor stimulus (GO:1990090)3.25407990
98response to nerve growth factor (GO:1990089)3.25407990
99negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.24362181
100positive regulation of cell size (GO:0045793)11.0189984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.73623854
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.20370560
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.90789031
4HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.95159582
5ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.94322571
6RUNX_20019798_ChIP-Seq_JUKART_Human2.53428298
7GATA1_22025678_ChIP-Seq_K562_Human2.41192626
8SCL_19346495_ChIP-Seq_HPC-7_Human2.36375633
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12856636
10ZNF274_21170338_ChIP-Seq_K562_Hela2.08897997
11NR3C1_21868756_ChIP-Seq_MCF10A_Human2.02076530
12EZH2_22144423_ChIP-Seq_EOC_Human12.7701648
13E2F7_22180533_ChIP-Seq_HELA_Human1.96183988
14GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.87024994
15SMC4_20622854_ChIP-Seq_HELA_Human1.86007598
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79034193
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70009258
18TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.64806268
19DROSHA_22980978_ChIP-Seq_HELA_Human1.62188897
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59683019
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57400197
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55268026
23P53_22127205_ChIP-Seq_FIBROBLAST_Human1.48240599
24PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46163014
25KDM2B_26808549_Chip-Seq_K562_Human1.42574112
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34769363
27AHR_22903824_ChIP-Seq_MCF-7_Human1.34517340
28CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.32650293
29TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32406887
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24387799
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22921465
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21315902
33SMAD3_21741376_ChIP-Seq_ESCs_Human1.17718929
34GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17108414
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15987334
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13395509
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08723083
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.07580862
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04912292
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.03614679
41FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03475833
42SMAD4_21741376_ChIP-Seq_ESCs_Human1.03358967
43TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00416784
44NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99824862
45JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99240842
46ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99033236
47KDM2B_26808549_Chip-Seq_DND41_Human0.97202060
48MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95029673
49TET1_21451524_ChIP-Seq_MESCs_Mouse0.94300715
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91639973
51GATA1_19941827_ChIP-Seq_MEL_Mouse0.91562051
52KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91545857
53SMAD4_21741376_ChIP-Seq_EPCs_Human0.91232989
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90508704
55ESR1_20079471_ChIP-ChIP_T-47D_Human0.90121175
56TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89451388
57REST_18959480_ChIP-ChIP_MESCs_Mouse0.88909993
58LXR_22292898_ChIP-Seq_THP-1_Human0.86229799
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85814156
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85206223
61RUNX1_27514584_Chip-Seq_MCF-7_Human0.84876586
62TBX20_22328084_ChIP-Seq_HEART_Mouse0.84873671
63TBX20_22080862_ChIP-Seq_HEART_Mouse0.84873671
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81024877
65TFEB_21752829_ChIP-Seq_HELA_Human0.80862335
66PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79957939
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79422666
68OCT1_27270436_Chip-Seq_PROSTATE_Human0.77688077
69ERG_20517297_ChIP-Seq_VCAP_Human0.77449252
70FOXA1_25552417_ChIP-Seq_VCAP_Human0.77305874
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77296968
72ERA_21632823_ChIP-Seq_H3396_Human0.76746847
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.76525016
74TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.75935769
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.75714989
76EZH2_27304074_Chip-Seq_ESCs_Mouse0.75062333
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74576151
78PRDM14_20953172_ChIP-Seq_ESCs_Human0.73201493
79GATA3_26560356_Chip-Seq_TH2_Human0.72469217
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.72469213
81CBX2_22325352_ChIP-Seq_293T-Rex_Human0.72300848
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.71654902
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71608449
84PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.71602921
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.70702386
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.70318657
87SUZ12_27294783_Chip-Seq_ESCs_Mouse0.70207525
88P68_20966046_ChIP-Seq_HELA_Human0.70196782
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70192573
90SOX2_22085726_ChIP-Seq_NPCs_Mouse0.69685351
91SA1_27219007_Chip-Seq_ERYTHROID_Human0.69518243
92SOX9_24532713_ChIP-Seq_HFSC_Mouse0.69082630
93MTF2_20144788_ChIP-Seq_MESCs_Mouse0.69054796
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68075281
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67935984
96GATA1_19941826_ChIP-Seq_K562_Human0.67796247
97SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.67731142
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.66655754
99FOXH1_21741376_ChIP-Seq_ESCs_Human0.65887283
100TCF4_22108803_ChIP-Seq_LS180_Human0.65693821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis8.20913786
2MP0003646_muscle_fatigue7.89704440
3MP0002234_abnormal_pharynx_morphology5.62857467
4MP0004233_abnormal_muscle_weight4.76992546
5MP0004858_abnormal_nervous_system4.76286503
6MP0010368_abnormal_lymphatic_system4.50753436
7MP0004043_abnormal_pH_regulation4.34578099
8MP0005167_abnormal_blood-brain_barrier4.06806117
9MP0005645_abnormal_hypothalamus_physiol4.01016135
10MP0009053_abnormal_anal_canal3.21219408
11MP0006082_CNS_inflammation2.97874249
12MP0003283_abnormal_digestive_organ2.66822895
13MP0004084_abnormal_cardiac_muscle2.58184986
14MP0003045_fibrosis2.45412195
15MP0000467_abnormal_esophagus_morphology2.10014623
16MP0002009_preneoplasia1.97565666
17MP0003718_maternal_effect1.91488044
18MP0005076_abnormal_cell_differentiation1.77344727
19MP0001919_abnormal_reproductive_system1.77142208
20MP0010307_abnormal_tumor_latency1.70510804
21MP0002233_abnormal_nose_morphology1.61535244
22MP0000733_abnormal_muscle_development1.60063936
23MP0001664_abnormal_digestion1.59462000
24MP0000537_abnormal_urethra_morphology1.47753863
25MP0001501_abnormal_sleep_pattern1.46326425
26MP0008872_abnormal_physiological_respon1.40248726
27MP0004036_abnormal_muscle_relaxation1.36712020
28MP0006138_congestive_heart_failure1.29123920
29MP0001879_abnormal_lymphatic_vessel1.22014133
30MP0000767_abnormal_smooth_muscle1.20490639
31MP0000470_abnormal_stomach_morphology1.18709500
32MP0004484_altered_response_of1.18441864
33MP0008775_abnormal_heart_ventricle1.17108886
34MP0004883_abnormal_blood_vessel1.07779348
35MP0002127_abnormal_cardiovascular_syste1.06606950
36MP0001764_abnormal_homeostasis1.02255829
37MP0005197_abnormal_uvea_morphology1.02065206
38MP0009764_decreased_sensitivity_to0.96181975
39MP0002109_abnormal_limb_morphology0.95194341
40MP0000383_abnormal_hair_follicle0.95101166
41MP0003937_abnormal_limbs/digits/tail_de0.93948539
42MP0001440_abnormal_grooming_behavior0.90564877
43MP0002116_abnormal_craniofacial_bone0.86947286
44MP0000490_abnormal_crypts_of0.86035297
45MP0000432_abnormal_head_morphology0.80290694
46MP0003075_altered_response_to0.78777015
47MP0005389_reproductive_system_phenotype0.77323744
48MP0005499_abnormal_olfactory_system0.74920983
49MP0005394_taste/olfaction_phenotype0.74920983
50MP0003123_paternal_imprinting0.73319059
51MP0002113_abnormal_skeleton_development0.72526601
52MP0004133_heterotaxia0.70686028
53MP0000163_abnormal_cartilage_morphology0.68187679
54MP0002396_abnormal_hematopoietic_system0.66819587
55MP0000955_abnormal_spinal_cord0.64127916
56MP0005166_decreased_susceptibility_to0.61676422
57MP0000631_abnormal_neuroendocrine_gland0.59039802
58MP0001756_abnormal_urination0.57698517
59MP0002168_other_aberrant_phenotype0.57690530
60MP0003633_abnormal_nervous_system0.57689586
61MP0000858_altered_metastatic_potential0.55809260
62MP0008058_abnormal_DNA_repair0.54981595
63MP0010329_abnormal_lipoprotein_level0.54711207
64MP0010678_abnormal_skin_adnexa0.54340789
65MP0005058_abnormal_lysosome_morphology0.53794069
66MP0003763_abnormal_thymus_physiology0.53314209
67MP0000477_abnormal_intestine_morphology0.52327823
68MP0003631_nervous_system_phenotype0.51980155
69MP0000428_abnormal_craniofacial_morphol0.50213621
70MP0001663_abnormal_digestive_system0.49579569
71MP0003942_abnormal_urinary_system0.45895229
72MP0008789_abnormal_olfactory_epithelium0.44884524
73MP0005332_abnormal_amino_acid0.44771006
74MP0004811_abnormal_neuron_physiology0.44519442
75MP0002115_abnormal_skeleton_extremities0.43055177
76MP0003315_abnormal_perineum_morphology0.42566142
77MP0001119_abnormal_female_reproductive0.40615925
78MP0009672_abnormal_birth_weight0.40328871
79MP0002932_abnormal_joint_morphology0.39355405
80MP0009745_abnormal_behavioral_response0.36978320
81MP0001784_abnormal_fluid_regulation0.35714997
82MP0005164_abnormal_response_to0.35425915
83MP0008260_abnormal_autophagy0.34931777
84MP0005367_renal/urinary_system_phenotyp0.34683764
85MP0000516_abnormal_urinary_system0.34683764
86MP0003119_abnormal_digestive_system0.34654755
87MP0003828_pulmonary_edema0.33800203
88MP0008874_decreased_physiological_sensi0.31250037
89MP0005395_other_phenotype0.30727379
90MP0002084_abnormal_developmental_patter0.30522932
91MP0003566_abnormal_cell_adhesion0.29548630
92MP0002064_seizures0.27540203
93MP0000538_abnormal_urinary_bladder0.26911249
94MP0002063_abnormal_learning/memory/cond0.26170976
95MP0001873_stomach_inflammation0.25717155
96MP0005670_abnormal_white_adipose0.25271265
97MP0003448_altered_tumor_morphology0.25100950
98MP0002132_abnormal_respiratory_system0.24858857
99MP0002272_abnormal_nervous_system0.24420739
100MP0002184_abnormal_innervation0.24394077

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)8.89412008
2Autoimmune thrombocytopenia (HP:0001973)8.82719930
3Sparse lateral eyebrow (HP:0005338)8.42943802
4Anal stenosis (HP:0002025)7.86275597
5Depressed nasal tip (HP:0000437)6.95449200
6Intestinal fistula (HP:0100819)6.77596177
7Abnormality of the fingertips (HP:0001211)6.65959007
8Ureteral stenosis (HP:0000071)6.05702714
9Short 5th finger (HP:0009237)5.79351743
10Ureteral obstruction (HP:0006000)5.57403428
11Aplasia/Hypoplasia of the 5th finger (HP:0006262)5.39792065
12Popliteal pterygium (HP:0009756)4.87335495
13Lower limb hyperreflexia (HP:0002395)4.85160590
14Ectopic kidney (HP:0000086)4.18159534
15Aplasia/Hypoplasia of the vertebrae (HP:0008515)4.12710509
16Vertebral hypoplasia (HP:0008417)4.12710509
17Mucopolysacchariduria (HP:0008155)4.00048633
18Urinary glycosaminoglycan excretion (HP:0003541)4.00048633
19Preauricular pit (HP:0004467)3.76329377
20Periauricular skin pits (HP:0100277)3.76329377
21Abnormality of mucopolysaccharide metabolism (HP:0011020)3.73706728
22Abnormality of polysaccharide metabolism (HP:0011012)3.73706728
23Abnormality of glycosaminoglycan metabolism (HP:0004371)3.73706728
24Long palpebral fissure (HP:0000637)3.73288557
25Posterior subcapsular cataract (HP:0007787)3.72138178
26Increased CSF protein (HP:0002922)3.52850892
27Dysostosis multiplex (HP:0000943)3.47281311
28Ectropion (HP:0000656)3.46587949
29Natal tooth (HP:0000695)3.17430956
30Abnormality of the distal phalanges of the toes (HP:0010182)2.94865339
31Abnormality of the periventricular white matter (HP:0002518)2.90706413
32Facial cleft (HP:0002006)2.87368661
33Absent eyebrow (HP:0002223)2.87099598
34Self-mutilation (HP:0000742)2.86741983
35Mask-like facies (HP:0000298)2.86334820
36Pheochromocytoma (HP:0002666)2.84046594
37Neonatal short-limb short stature (HP:0008921)2.77313589
38Wide intermamillary distance (HP:0006610)2.66695616
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.66421483
40Absent eyelashes (HP:0000561)2.66036547
41Broad thumb (HP:0011304)2.61730167
42Narrow palate (HP:0000189)2.55662888
43Fibular aplasia (HP:0002990)2.52005533
44Preaxial foot polydactyly (HP:0001841)2.51915382
45Recurrent otitis media (HP:0000403)2.51673384
46Congenital hip dislocation (HP:0001374)2.51124943
47Leiomyosarcoma (HP:0100243)2.49008733
48Uterine leiomyosarcoma (HP:0002891)2.49008733
49Aplasia involving bones of the upper limbs (HP:0009823)2.46450177
50Aplasia of the phalanges of the hand (HP:0009802)2.46450177
51Aplasia involving bones of the extremities (HP:0009825)2.46450177
52Pterygium (HP:0001059)2.41327790
53Non-midline cleft lip (HP:0100335)2.41030991
54Progressive neurologic deterioration (HP:0002344)2.40802607
55Neuroendocrine neoplasm (HP:0100634)2.40255563
56Skin pits (HP:0100276)2.40207174
57Coarctation of aorta (HP:0001680)2.38974178
58Renal cell carcinoma (HP:0005584)2.38921230
59Broad hallux (HP:0010055)2.35908449
60Neonatal death (HP:0003811)2.33997251
61Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.31848760
62Trismus (HP:0000211)2.31311149
63Atonic seizures (HP:0010819)2.30467597
64Generalized aminoaciduria (HP:0002909)2.27611113
65Fatigue (HP:0012378)2.22719052
66Anal atresia (HP:0002023)2.20266077
67Frequent falls (HP:0002359)2.18517539
68Hypoplastic labia majora (HP:0000059)2.17260258
69Transitional cell carcinoma of the bladder (HP:0006740)2.15754676
70Confusion (HP:0001289)2.13641178
71Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.08832478
72Facial shape deformation (HP:0011334)2.06767799
73Potter facies (HP:0002009)2.06767799
74Asymmetry of the thorax (HP:0001555)2.06008668
75Tubulointerstitial fibrosis (HP:0005576)2.05571972
76Subcapsular cataract (HP:0000523)2.02862612
77Abnormality of the labia majora (HP:0012881)2.01445427
78Abnormality of the renal cortex (HP:0011035)2.01418838
79Abnormality of cochlea (HP:0000375)1.98571761
80Blue irides (HP:0000635)1.96711216
81Poor head control (HP:0002421)1.96636142
82Obstructive sleep apnea (HP:0002870)1.95554988
83Tubular atrophy (HP:0000092)1.93987831
84Bladder carcinoma (HP:0002862)1.91728404
85Bladder neoplasm (HP:0009725)1.91728404
86Flat face (HP:0012368)1.90051744
87Polydipsia (HP:0001959)1.88888672
88Abnormal drinking behavior (HP:0030082)1.88888672
89Broad phalanges of the hand (HP:0009768)1.88521064
90Broad toe (HP:0001837)1.88274528
91Abnormal number of incisors (HP:0011064)1.86154659
92Absent thumb (HP:0009777)1.84968548
93Concave nail (HP:0001598)1.81131298
94Chronic bronchitis (HP:0004469)1.80903396
95Conical tooth (HP:0000698)1.80148095
96Spontaneous abortion (HP:0005268)1.75997325
97Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73623008
98Absent hand (HP:0004050)1.73548751
99Broad finger (HP:0001500)1.73034905
100Advanced eruption of teeth (HP:0006288)1.72997300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK248.81011583
2STK395.50293465
3WNK45.49044614
4CCNB14.74934577
5PINK14.17901368
6MAP3K24.07724428
7MAP3K33.95868117
8EEF2K3.80447839
9JAK32.94209388
10ILK2.42428262
11MAPKAPK32.26355830
12WNK12.11878406
13ZAK2.07019085
14CAMK41.57528850
15CAMK11.57173628
16RPS6KL11.38681811
17RPS6KC11.38681811
18CHEK21.38291046
19RPS6KA61.34133210
20PRKCQ1.30394965
21TRPM71.27903815
22NTRK21.25020442
23CDC71.15441900
24SRPK10.98366969
25MAPKAPK50.95439174
26CAMK1G0.93252395
27RPS6KB20.92510299
28MINK10.76258417
29CAMKK20.75668959
30TTK0.75609047
31RPS6KA20.70511093
32CAMK1D0.66977101
33DAPK20.66863751
34CDK90.57778139
35NEK90.56326284
36PNCK0.54414625
37TNIK0.51627257
38ACVR1B0.48098636
39STK40.45491396
40IRAK30.44864743
41MAPK130.43442684
42CAMKK10.42170207
43PASK0.38217563
44TNK20.35006036
45DYRK30.32494300
46HCK0.31314758
47YES10.29488910
48EGFR0.27724037
49MELK0.27697047
50PRPF4B0.27553139
51EIF2AK20.27478482
52MAP3K100.26757947
53BCKDK0.26134533
54GRK10.22262582
55CSNK1G30.21614769
56WEE10.17412075
57RPS6KB10.16478977
58ADRBK10.16276304
59JAK10.15405325
60SGK20.15221058
61PRKCD0.15005648
62MAPK120.14931607
63CSNK1A1L0.13698240
64PRKCZ0.13598284
65PRKCG0.11924684
66PRKACG0.11423101
67MAPK110.10786600
68MAPK90.10689501
69MTOR0.09983058
70CSNK1G20.09633303
71BMPR1B0.09608380
72MAP3K50.09225485
73PRKG20.09082462
74CSNK1G10.07408232
75PRKCA0.06834312
76KIT0.06765493
77ERBB30.04847357
78IRAK20.03626266
79PIM10.03540902
80MAP3K110.03026273
81CAMK2A0.02474816
82BMX0.02122038
83FER0.02010282
84SGK4940.00993595
85SGK2230.00993595
86PRKACA0.00235464
87PRKCE0.00020914
88RPS6KA1-0.0625200
89OBSCN-0.0619123
90SGK3-0.0522405
91ABL1-0.0490454
92MAP2K1-0.0478961
93ROCK1-0.0465281
94ERBB2-0.0312891
95SRC-0.0284970
96TXK-0.0248936
97MAP4K2-0.0211135
98IRAK4-0.0208145
99INSR-0.0151115
100CDK2-0.0117776

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002208.93947633
2Drug metabolism - other enzymes_Homo sapiens_hsa009834.20725488
3Lysine degradation_Homo sapiens_hsa003103.84426306
4AMPK signaling pathway_Homo sapiens_hsa041523.33863970
5Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.52467940
6Phototransduction_Homo sapiens_hsa047442.46039215
7N-Glycan biosynthesis_Homo sapiens_hsa005102.14770079
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09911348
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.07329339
10One carbon pool by folate_Homo sapiens_hsa006701.82604596
11Circadian entrainment_Homo sapiens_hsa047131.81141068
12Salivary secretion_Homo sapiens_hsa049701.72250439
13Arginine and proline metabolism_Homo sapiens_hsa003301.65101106
14Pyrimidine metabolism_Homo sapiens_hsa002401.63649049
15Dopaminergic synapse_Homo sapiens_hsa047281.62069112
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53759254
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51169295
18Long-term depression_Homo sapiens_hsa047301.44794169
19Selenocompound metabolism_Homo sapiens_hsa004501.44476389
20Nitrogen metabolism_Homo sapiens_hsa009101.43476345
21Sphingolipid signaling pathway_Homo sapiens_hsa040711.41201335
22Caffeine metabolism_Homo sapiens_hsa002321.38920058
23TGF-beta signaling pathway_Homo sapiens_hsa043501.37035027
24Non-homologous end-joining_Homo sapiens_hsa034501.33148448
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27573528
26Insulin signaling pathway_Homo sapiens_hsa049101.18693058
27Vitamin B6 metabolism_Homo sapiens_hsa007501.18669215
28mRNA surveillance pathway_Homo sapiens_hsa030151.15805582
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.12903601
30Fatty acid elongation_Homo sapiens_hsa000621.11514867
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11162132
32Vitamin digestion and absorption_Homo sapiens_hsa049771.07900591
33Renal cell carcinoma_Homo sapiens_hsa052111.04666199
34Neurotrophin signaling pathway_Homo sapiens_hsa047220.95261774
35Taste transduction_Homo sapiens_hsa047420.94573901
36Pertussis_Homo sapiens_hsa051330.91156872
37Hippo signaling pathway_Homo sapiens_hsa043900.85550243
38Adherens junction_Homo sapiens_hsa045200.84346995
39Phagosome_Homo sapiens_hsa041450.82537111
40Olfactory transduction_Homo sapiens_hsa047400.81317823
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78440106
42Endocytosis_Homo sapiens_hsa041440.76660377
43Other glycan degradation_Homo sapiens_hsa005110.74485864
44Oxytocin signaling pathway_Homo sapiens_hsa049210.73877154
45Glioma_Homo sapiens_hsa052140.71813279
46beta-Alanine metabolism_Homo sapiens_hsa004100.67591671
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65714106
48Amphetamine addiction_Homo sapiens_hsa050310.62140893
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.61311357
50Calcium signaling pathway_Homo sapiens_hsa040200.57309931
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56807617
52Renin secretion_Homo sapiens_hsa049240.56081192
53Nucleotide excision repair_Homo sapiens_hsa034200.54546857
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53877374
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52416250
56Glycerolipid metabolism_Homo sapiens_hsa005610.50237424
57PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49778331
58Complement and coagulation cascades_Homo sapiens_hsa046100.49050856
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48995458
60p53 signaling pathway_Homo sapiens_hsa041150.44780864
61Tyrosine metabolism_Homo sapiens_hsa003500.41026064
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.40383245
63Rap1 signaling pathway_Homo sapiens_hsa040150.39062187
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38875928
65PPAR signaling pathway_Homo sapiens_hsa033200.38638358
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37208984
67Butanoate metabolism_Homo sapiens_hsa006500.37051071
68mTOR signaling pathway_Homo sapiens_hsa041500.35641113
69Alcoholism_Homo sapiens_hsa050340.31442272
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31272806
71Retinol metabolism_Homo sapiens_hsa008300.30511921
72Measles_Homo sapiens_hsa051620.29106941
73Gastric acid secretion_Homo sapiens_hsa049710.28547001
74Lysosome_Homo sapiens_hsa041420.25835146
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24518148
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23136252
77Chemical carcinogenesis_Homo sapiens_hsa052040.22608194
78cAMP signaling pathway_Homo sapiens_hsa040240.22554939
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.21393829
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20631143
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20289001
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20131798
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19476879
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.19381605
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18385435
86Biosynthesis of amino acids_Homo sapiens_hsa012300.17100046
87ECM-receptor interaction_Homo sapiens_hsa045120.16841484
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16837307
89Long-term potentiation_Homo sapiens_hsa047200.15741485
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15449488
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15169147
92Dilated cardiomyopathy_Homo sapiens_hsa054140.14257503
93Melanogenesis_Homo sapiens_hsa049160.13345050
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13043550
95Focal adhesion_Homo sapiens_hsa045100.12453004
96Collecting duct acid secretion_Homo sapiens_hsa049660.12084039
97Starch and sucrose metabolism_Homo sapiens_hsa005000.11035023
98African trypanosomiasis_Homo sapiens_hsa051430.10989100
99Folate biosynthesis_Homo sapiens_hsa007900.10239325
100Peroxisome_Homo sapiens_hsa041460.10098282

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