ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	8.16810228
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	6.77774776
3	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	6.77774776
4	pseudouridine synthesis (GO:0001522)	6.76160089
5	cysteine metabolic process (GO:0006534)	6.34902141
6	homocysteine metabolic process (GO:0050667)	6.08154560
7	nucleoside transmembrane transport (GO:1901642)	5.94015211
8	folic acid-containing compound biosynthetic process (GO:0009396)	5.76776570
9	negative regulation of organelle assembly (GO:1902116)	5.70865346
10	regulation of plasminogen activation (GO:0010755)	5.51632992
11	sulfur amino acid catabolic process (GO:0000098)	5.38013861
12	desmosome organization (GO:0002934)	5.35783882
13	negative regulation of DNA biosynthetic process (GO:2000279)	5.24586535
14	negative regulation of interleukin-1 beta production (GO:0032691)	5.08210278
15	pteridine-containing compound biosynthetic process (GO:0042559)	4.74232020
16	negative regulation of telomerase activity (GO:0051974)	4.74224014
17	antigen processing and presentation via MHC class Ib (GO:0002475)	4.70545763
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.70362188
19	NADH dehydrogenase complex assembly (GO:0010257)	4.70362188
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.70362188
21	purine nucleotide salvage (GO:0032261)	4.65249060
22	growth hormone secretion (GO:0030252)	4.53064741
23	atrial cardiac muscle cell action potential (GO:0086014)	4.46598298
24	adult feeding behavior (GO:0008343)	4.41587494
25	regulation of gonadotropin secretion (GO:0032276)	4.34396337
26	kidney morphogenesis (GO:0060993)	4.33175443
27	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.31462396
28	negative regulation of interleukin-1 production (GO:0032692)	4.28968735
29	positive regulation of respiratory burst (GO:0060267)	4.19610389
30	gap junction assembly (GO:0016264)	4.18401898
31	inner ear receptor cell development (GO:0060119)	4.13698144
32	nucleoside transport (GO:0015858)	4.03827318
33	mitochondrial RNA metabolic process (GO:0000959)	4.02356724
34	adenosine metabolic process (GO:0046085)	3.94401120
35	DNA deamination (GO:0045006)	3.94007855
36	postsynaptic membrane organization (GO:0001941)	3.93542303
37	primary amino compound metabolic process (GO:1901160)	3.93423637
38	peristalsis (GO:0030432)	3.91605147
39	white fat cell differentiation (GO:0050872)	3.91233298
40	galactose catabolic process (GO:0019388)	3.88433130
41	microtubule nucleation (GO:0007020)	3.82013109
42	negative regulation of catenin import into nucleus (GO:0035414)	3.74958540
43	platelet dense granule organization (GO:0060155)	3.68239409
44	urinary tract smooth muscle contraction (GO:0014848)	3.62578314
45	L-serine metabolic process (GO:0006563)	3.58468731
46	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.56874750
47	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.56272501
48	alternative mRNA splicing, via spliceosome (GO:0000380)	3.55470930
49	protein complex biogenesis (GO:0070271)	3.54477729
50	response to xenobiotic stimulus (GO:0009410)	3.48742100
51	positive regulation of antigen processing and presentation (GO:0002579)	3.48652396
52	tRNA modification (GO:0006400)	3.47542338
53	regulation of sequestering of triglyceride (GO:0010889)	3.47343988
54	DNA-dependent DNA replication (GO:0006261)	3.45251912
55	phasic smooth muscle contraction (GO:0014821)	3.44949060
56	IMP biosynthetic process (GO:0006188)	3.35940551
57	serine family amino acid biosynthetic process (GO:0009070)	3.32166690
58	innervation (GO:0060384)	3.26967929
59	behavioral response to nicotine (GO:0035095)	3.25162930
60	mitochondrial respiratory chain complex assembly (GO:0033108)	3.24810744
61	protein-cofactor linkage (GO:0018065)	3.24428833
62	arginine catabolic process (GO:0006527)	3.23431070
63	sulfur amino acid biosynthetic process (GO:0000097)	3.22530576
64	tRNA processing (GO:0008033)	3.21433678
65	energy homeostasis (GO:0097009)	3.20047267
66	positive regulation of guanylate cyclase activity (GO:0031284)	3.16837888
67	photoreceptor cell differentiation (GO:0046530)	3.13612942
68	eye photoreceptor cell differentiation (GO:0001754)	3.13612942
69	ribosome biogenesis (GO:0042254)	3.10510878
70	response to food (GO:0032094)	3.10171170
71	primary alcohol catabolic process (GO:0034310)	3.09221507
72	regulation of telomerase activity (GO:0051972)	3.08794340
73	tetrahydrofolate metabolic process (GO:0046653)	3.07941642
74	polyamine metabolic process (GO:0006595)	3.07205363
75	tRNA methylation (GO:0030488)	3.03932398
76	galactose metabolic process (GO:0006012)	3.01430672
77	activin receptor signaling pathway (GO:0032924)	3.01337992
78	ATP hydrolysis coupled proton transport (GO:0015991)	3.00516373
79	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.00516373
80	negative regulation of insulin secretion (GO:0046676)	2.98711866
81	positive regulation of endothelial cell differentiation (GO:0045603)	2.97858864
82	rRNA methylation (GO:0031167)	2.97572383
83	G-protein coupled receptor internalization (GO:0002031)	2.95763108
84	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.94108343
85	amino acid salvage (GO:0043102)	2.92447640
86	L-methionine salvage (GO:0071267)	2.92447640
87	L-methionine biosynthetic process (GO:0071265)	2.92447640
88	regulation of response to food (GO:0032095)	2.92003304
89	folic acid-containing compound metabolic process (GO:0006760)	2.90560716
90	embryonic foregut morphogenesis (GO:0048617)	2.88861614
91	parturition (GO:0007567)	2.87476086
92	IMP metabolic process (GO:0046040)	2.86882019
93	organic cation transport (GO:0015695)	2.86092401
94	RNA modification (GO:0009451)	2.84382866
95	regulation of guanylate cyclase activity (GO:0031282)	2.84017065
96	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.82885654
97	histone H4-K12 acetylation (GO:0043983)	2.82122574
98	positive regulation of fatty acid metabolic process (GO:0045923)	2.81220982
99	regulation of antigen processing and presentation (GO:0002577)	2.81005054
100	transcription from mitochondrial promoter (GO:0006390)	2.79751532

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	7.54490469
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.03227217
3	GATA1_22025678_ChIP-Seq_K562_Human	4.75862516
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.22103910
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.62906564
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.54385047
7	VDR_22108803_ChIP-Seq_LS180_Human	2.33331904
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.29870530
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.24379448
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.12380242
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.08640497
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.97999036
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.83937246
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77178926
15	TP53_22573176_ChIP-Seq_HFKS_Human	1.76183800
16	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.68876166
17	HOXB7_26014856_ChIP-Seq_BT474_Human	1.62509140
18	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.61471833
19	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.53161818
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.49990781
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.47710802
22	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.43163061
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.42646925
24	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.42631289
25	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.38588316
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.36645164
27	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.35993278
28	MYC_19829295_ChIP-Seq_ESCs_Human	1.35784627
29	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.34133598
30	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.34006377
31	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.31649480
32	NCOR_22424771_ChIP-Seq_293T_Human	1.29982415
33	EZH2_22144423_ChIP-Seq_EOC_Human	1.28048817
34	ERA_21632823_ChIP-Seq_H3396_Human	1.26344304
35	NANOG_20526341_ChIP-Seq_ESCs_Human	1.25030228
36	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.24975072
37	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.22674701
38	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.21412034
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21293821
40	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.18370339
41	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.17405953
42	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16511957
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14833976
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14833976
45	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.14481189
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.13181922
47	CDX2_22108803_ChIP-Seq_LS180_Human	1.12854981
48	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.11681988
49	GABP_19822575_ChIP-Seq_HepG2_Human	1.11325007
50	GATA4_25053715_ChIP-Seq_YYC3_Human	1.11066590
51	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.09939914
52	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.09841664
53	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08712433
54	ERG_20517297_ChIP-Seq_VCAP_Human	1.07134813
55	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.06143089
56	FOXP3_21729870_ChIP-Seq_TREG_Human	1.05938164
57	P53_21459846_ChIP-Seq_SAOS-2_Human	1.05840441
58	OCT4_20526341_ChIP-Seq_ESCs_Human	1.05225617
59	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.04337819
60	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.02293648
61	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.00295373
62	CTCF_20526341_ChIP-Seq_ESCs_Human	0.99816809
63	ZNF263_19887448_ChIP-Seq_K562_Human	0.98862102
64	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.98735824
65	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.98522496
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.97742648
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97152960
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96502187
69	FUS_26573619_Chip-Seq_HEK293_Human	0.95498250
70	SMAD4_21741376_ChIP-Seq_ESCs_Human	0.94475505
71	AR_20517297_ChIP-Seq_VCAP_Human	0.94387386
72	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.93532713
73	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.93356302
74	P68_20966046_ChIP-Seq_HELA_Human	0.91930928
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.91154111
76	SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.90955511
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.90406324
78	SOX2_21211035_ChIP-Seq_LN229_Human	0.90203746
79	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.90047807
80	SPI1_20517297_ChIP-Seq_HL60_Human	0.90044076
81	TCF4_22108803_ChIP-Seq_LS180_Human	0.89261513
82	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.88974083
83	BCOR_27268052_Chip-Seq_Bcells_Human	0.88671766
84	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.88473683
85	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.88192772
86	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.86635292
87	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.86431421
88	REST_21632747_ChIP-Seq_MESCs_Mouse	0.86378130
89	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.84510211
90	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.83876742
91	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.83420433
92	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.83251509
93	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.83055776
94	E2F1_20622854_ChIP-Seq_HELA_Human	0.80758971
95	RNF2_27304074_Chip-Seq_NSC_Mouse	0.80517192
96	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.80517126
97	EWS_26573619_Chip-Seq_HEK293_Human	0.79520800
98	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.78682487
99	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.78667964
100	CEBPB_22108803_ChIP-Seq_LS180_Human	0.78634837

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	7.89796133
2	MP0005360_urolithiasis	3.70989825
3	MP0005670_abnormal_white_adipose	3.41725986
4	MP0001348_abnormal_lacrimal_gland	3.33050440
5	MP0005167_abnormal_blood-brain_barrier	3.12930065
6	MP0002735_abnormal_chemical_nociception	3.04113495
7	MP0005646_abnormal_pituitary_gland	3.00569685
8	MP0004885_abnormal_endolymph	2.86946291
9	MP0003646_muscle_fatigue	2.75712074
10	MP0008872_abnormal_physiological_respon	2.71748949
11	MP0004043_abnormal_pH_regulation	2.58247856
12	MP0004185_abnormal_adipocyte_glucose	2.53705779
13	MP0001661_extended_life_span	2.45473563
14	MP0003186_abnormal_redox_activity	2.33323798
15	MP0003806_abnormal_nucleotide_metabolis	2.29939450
16	MP0008995_early_reproductive_senescence	2.29443273
17	MP0010030_abnormal_orbit_morphology	2.18483878
18	MP0003183_abnormal_peptide_metabolism	2.11444181
19	MP0002736_abnormal_nociception_after	2.04676087
20	MP0009840_abnormal_foam_cell	1.99564239
21	MP0002938_white_spotting	1.96387742
22	MP0002132_abnormal_respiratory_system	1.89705967
23	MP0001849_ear_inflammation	1.83899266
24	MP0000013_abnormal_adipose_tissue	1.80246599
25	MP0000534_abnormal_ureter_morphology	1.78299470
26	MP0008875_abnormal_xenobiotic_pharmacok	1.65742662
27	MP0002837_dystrophic_cardiac_calcinosis	1.52834013
28	MP0005332_abnormal_amino_acid	1.52747439
29	MP0008877_abnormal_DNA_methylation	1.50389038
30	MP0009379_abnormal_foot_pigmentation	1.48016350
31	MP0003890_abnormal_embryonic-extraembry	1.47614646
32	MP0001764_abnormal_homeostasis	1.47318792
33	MP0006292_abnormal_olfactory_placode	1.42629129
34	MP0004133_heterotaxia	1.39161009
35	MP0005551_abnormal_eye_electrophysiolog	1.34061216
36	MP0003705_abnormal_hypodermis_morpholog	1.27746068
37	MP0002733_abnormal_thermal_nociception	1.19333405
38	MP0009697_abnormal_copulation	1.17517156
39	MP0003942_abnormal_urinary_system	1.13617641
40	MP0005367_renal/urinary_system_phenotyp	1.10736478
41	MP0000516_abnormal_urinary_system	1.10736478
42	MP0005253_abnormal_eye_physiology	1.09698896
43	MP0003638_abnormal_response/metabolism_	1.08777299
44	MP0003718_maternal_effect	1.08296041
45	MP0004130_abnormal_muscle_cell	1.06817910
46	MP0001486_abnormal_startle_reflex	1.03444679
47	MP0001851_eye_inflammation	1.03262916
48	MP0000538_abnormal_urinary_bladder	1.02370569
49	MP0002734_abnormal_mechanical_nocicepti	1.01256483
50	MP0000230_abnormal_systemic_arterial	1.00210411
51	MP0002160_abnormal_reproductive_system	0.98814971
52	MP0001968_abnormal_touch/_nociception	0.98138391
53	MP0001970_abnormal_pain_threshold	0.97322245
54	MP0008775_abnormal_heart_ventricle	0.96955926
55	MP0005085_abnormal_gallbladder_physiolo	0.92420869
56	MP0009643_abnormal_urine_homeostasis	0.92219384
57	MP0002127_abnormal_cardiovascular_syste	0.89743697
58	MP0006276_abnormal_autonomic_nervous	0.86669306
59	MP0002095_abnormal_skin_pigmentation	0.86367017
60	MP0003045_fibrosis	0.85334859
61	MP0002876_abnormal_thyroid_physiology	0.85310689
62	MP0005595_abnormal_vascular_smooth	0.85130744
63	MP0005636_abnormal_mineral_homeostasis	0.84005848
64	MP0005410_abnormal_fertilization	0.83917061
65	MP0003195_calcinosis	0.81187867
66	MP0005389_reproductive_system_phenotype	0.78232770
67	MP0009745_abnormal_behavioral_response	0.77088450
68	MP0002210_abnormal_sex_determination	0.75863772
69	MP0009384_cardiac_valve_regurgitation	0.75109468
70	MP0005076_abnormal_cell_differentiation	0.73386220
71	MP0001756_abnormal_urination	0.72637598
72	MP0002254_reproductive_system_inflammat	0.72480616
73	MP0004142_abnormal_muscle_tone	0.72431101
74	MP0003137_abnormal_impulse_conducting	0.71981037
75	MP0001270_distended_abdomen	0.70557353
76	MP0003950_abnormal_plasma_membrane	0.70424120
77	MP0002282_abnormal_trachea_morphology	0.69262923
78	MP0000383_abnormal_hair_follicle	0.67677109
79	MP0005666_abnormal_adipose_tissue	0.67422276
80	MP0003953_abnormal_hormone_level	0.67101585
81	MP0005645_abnormal_hypothalamus_physiol	0.65695946
82	MP0000613_abnormal_salivary_gland	0.65066809
83	MP0004019_abnormal_vitamin_homeostasis	0.64431669
84	MP0002638_abnormal_pupillary_reflex	0.64190000
85	MP0009046_muscle_twitch	0.62958317
86	MP0004233_abnormal_muscle_weight	0.62664546
87	MP0000647_abnormal_sebaceous_gland	0.61368006
88	MP0004084_abnormal_cardiac_muscle	0.60120192
89	MP0002249_abnormal_larynx_morphology	0.59700716
90	MP0003880_abnormal_central_pattern	0.58747139
91	MP0001919_abnormal_reproductive_system	0.58038036
92	MP0005377_hearing/vestibular/ear_phenot	0.57588917
93	MP0003878_abnormal_ear_physiology	0.57588917
94	MP0005448_abnormal_energy_balance	0.57207232
95	MP0004085_abnormal_heartbeat	0.56984796
96	MP0001986_abnormal_taste_sensitivity	0.55799793
97	MP0001905_abnormal_dopamine_level	0.55319489
98	MP0000678_abnormal_parathyroid_gland	0.55176412
99	MP0001963_abnormal_hearing_physiology	0.55070459
100	MP0005248_abnormal_Harderian_gland	0.54404845

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Breast hypoplasia (HP:0003187)	7.56967257
2	Hyperalaninemia (HP:0003348)	6.75514241
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	6.75514241
4	Abnormality of alanine metabolism (HP:0010916)	6.75514241
5	Poor speech (HP:0002465)	4.82000555
6	Congenital sensorineural hearing impairment (HP:0008527)	4.68823887
7	Aplasia/Hypoplasia of the sternum (HP:0006714)	4.58407548
8	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.40337878
9	Microretrognathia (HP:0000308)	4.39721192
10	Diastasis recti (HP:0001540)	3.90002519
11	Constricted visual fields (HP:0001133)	3.84290889
12	Chorioretinal atrophy (HP:0000533)	3.40873356
13	Slender long bone (HP:0003100)	3.34875509
14	Esophageal varix (HP:0002040)	3.26494831
15	Abnormality of homocysteine metabolism (HP:0010919)	3.08161706
16	Homocystinuria (HP:0002156)	3.08161706
17	Patellar aplasia (HP:0006443)	3.03151707
18	Aplasia/Hypoplasia of the patella (HP:0006498)	2.93080228
19	Pigmentary retinal degeneration (HP:0001146)	2.87220702
20	Hypoplastic left heart (HP:0004383)	2.85340270
21	Pendular nystagmus (HP:0012043)	2.82336172
22	True hermaphroditism (HP:0010459)	2.71007590
23	Female pseudohermaphroditism (HP:0010458)	2.70870471
24	Genu varum (HP:0002970)	2.68174677
25	White forelock (HP:0002211)	2.66277361
26	Abnormality of serum amino acid levels (HP:0003112)	2.66217750
27	Breast aplasia (HP:0100783)	2.60332442
28	Abnormality of the clitoris (HP:0000056)	2.58135260
29	Spontaneous hematomas (HP:0007420)	2.56870106
30	Inability to walk (HP:0002540)	2.54705658
31	Long foot (HP:0001833)	2.51538606
32	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.51018511
33	Hyperventilation (HP:0002883)	2.50315452
34	Anorexia (HP:0002039)	2.49860299
35	Abnormal respiratory epithelium morphology (HP:0012253)	2.49743482
36	Abnormal respiratory motile cilium morphology (HP:0005938)	2.49743482
37	Poor head control (HP:0002421)	2.47023795
38	Myokymia (HP:0002411)	2.46645661
39	Large eyes (HP:0001090)	2.42038426
40	Aplasia/Hypoplasia of the breasts (HP:0010311)	2.41297564
41	Conjugated hyperbilirubinemia (HP:0002908)	2.40841558
42	Cone-rod dystrophy (HP:0000548)	2.40651896
43	Oligomenorrhea (HP:0000876)	2.40210503
44	Congenital stationary night blindness (HP:0007642)	2.36165556
45	Type II lissencephaly (HP:0007260)	2.35046246
46	Depressed nasal tip (HP:0000437)	2.34429274
47	Attenuation of retinal blood vessels (HP:0007843)	2.33041734
48	Patchy hypopigmentation of hair (HP:0011365)	2.27477808
49	Hypoplastic heart (HP:0001961)	2.24797129
50	Scrotal hypoplasia (HP:0000046)	2.23338250
51	Chronic hepatic failure (HP:0100626)	2.23103036
52	Abnormal umbilical cord blood vessels (HP:0011403)	2.13641277
53	Single umbilical artery (HP:0001195)	2.13641277
54	Abnormality of the fetal cardiovascular system (HP:0010948)	2.13641277
55	Maternal diabetes (HP:0009800)	2.13100039
56	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.11868113
57	Pancreatic cysts (HP:0001737)	2.10361718
58	Action tremor (HP:0002345)	2.07285344
59	Abnormal lung lobation (HP:0002101)	2.06380335
60	Ileus (HP:0002595)	2.02832756
61	Abnormality of the labia minora (HP:0012880)	2.01218249
62	Birth length less than 3rd percentile (HP:0003561)	11.9350126
63	Coxa vara (HP:0002812)	1.98987109
64	Gonadal dysgenesis (HP:0000133)	1.95843169
65	Reticulocytopenia (HP:0001896)	1.95142602
66	Mesangial abnormality (HP:0001966)	1.92070372
67	Acute necrotizing encephalopathy (HP:0006965)	1.88776190
68	Proximal tubulopathy (HP:0000114)	1.87694819
69	Conjunctival telangiectasia (HP:0000524)	1.87208128
70	Cortical visual impairment (HP:0100704)	1.84815074
71	Molar tooth sign on MRI (HP:0002419)	1.82595286
72	Abnormality of midbrain morphology (HP:0002418)	1.82595286
73	Keratoconus (HP:0000563)	1.81132564
74	Increased corneal curvature (HP:0100692)	1.81132564
75	Lissencephaly (HP:0001339)	1.80126069
76	Microtia (HP:0008551)	1.79881126
77	Hypoalphalipoproteinemia (HP:0003233)	1.77702030
78	Nephronophthisis (HP:0000090)	1.76390613
79	Focal segmental glomerulosclerosis (HP:0000097)	1.74656928
80	Male pseudohermaphroditism (HP:0000037)	1.72612923
81	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.72095369
82	Abnormal pancreas size (HP:0012094)	1.71896767
83	Pancreatic fibrosis (HP:0100732)	1.71256432
84	Myocardial infarction (HP:0001658)	1.70878504
85	Hip dysplasia (HP:0001385)	1.69039596
86	Acute encephalopathy (HP:0006846)	1.67482853
87	Mitochondrial inheritance (HP:0001427)	1.65359971
88	Abnormality of the renal collecting system (HP:0004742)	1.62428808
89	Generalized aminoaciduria (HP:0002909)	1.62241629
90	Increased CSF lactate (HP:0002490)	1.60068404
91	Abnormality of the renal cortex (HP:0011035)	1.59621242
92	Disproportionate tall stature (HP:0001519)	1.59349077
93	Nasal speech (HP:0001611)	1.58780897
94	Duplicated collecting system (HP:0000081)	1.58744062
95	Glomerulosclerosis (HP:0000096)	1.58638427
96	Increased serum lactate (HP:0002151)	1.58080792
97	Abnormality of the vitreous humor (HP:0004327)	1.56892816
98	Biconcave vertebral bodies (HP:0004586)	1.54500018
99	Decreased subcutaneous fat (HP:0001002)	1.54340050
100	Hyperglycinemia (HP:0002154)	1.54139720

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	9.12421154
2	BMPR1B	5.52115430
3	DAPK2	4.23221323
4	CASK	3.18282574
5	TGFBR1	2.90492446
6	CAMKK1	2.49082085
7	MAP3K3	2.19253400
8	FGR	2.14139170
9	NME1	2.11807444
10	NTRK2	2.09715960
11	MAP2K3	2.00354641
12	WNK4	1.96789966
13	RPS6KB2	1.78897299
14	PINK1	1.78139346
15	ZAK	1.77887266
16	ADRBK1	1.68363370
17	SGK494	1.61201643
18	SGK223	1.61201643
19	MAP2K1	1.50284295
20	JAK3	1.43841208
21	CAMK1	1.28340319
22	NTRK3	1.24126127
23	MAP3K7	1.17531077
24	PDK2	1.16441462
25	NEK9	1.16223362
26	CAMK1D	1.14372349
27	SGK2	1.13037485
28	STK38L	1.12833173
29	CAMKK2	1.11200471
30	ADRBK2	1.07998630
31	EPHB2	1.05679686
32	PRKG2	1.02162475
33	MELK	1.01759452
34	MKNK2	0.99811745
35	EPHA2	0.98291388
36	PTK2B	0.93544091
37	DYRK2	0.91461115
38	CDK9	0.89029564
39	LMTK2	0.86826618
40	MAP2K6	0.84811000
41	PHKG2	0.79117917
42	PHKG1	0.79117917
43	CSNK1A1	0.76653842
44	NEK2	0.74355210
45	CAMK2A	0.69775803
46	CAMK1G	0.69459741
47	PRKCI	0.67225930
48	FRK	0.64778653
49	MAP4K2	0.62373391
50	AURKA	0.60984573
51	CAMK4	0.60928737
52	GRK1	0.60637375
53	SGK3	0.60200477
54	RPS6KA6	0.60067071
55	PTK6	0.53286745
56	CCNB1	0.50915327
57	NEK1	0.50295402
58	ABL2	0.48092034
59	MAP3K11	0.45313212
60	CAMK2D	0.45285503
61	OXSR1	0.45139662
62	TIE1	0.44987663
63	CDK4	0.43065674
64	SGK1	0.42449280
65	MAP2K7	0.41568180
66	TLK1	0.37868309
67	PRKAA2	0.36947579
68	STK39	0.36056817
69	PLK4	0.35040425
70	TNIK	0.34175195
71	PRKCQ	0.33321707
72	BCKDK	0.32356593
73	CAMK2B	0.32305257
74	CAMK2G	0.31451344
75	ALK	0.31384476
76	PRKCE	0.30969783
77	PRKCD	0.30649750
78	IKBKB	0.30328592
79	MAP4K1	0.30078710
80	PRKACA	0.29334707
81	WNK1	0.28725710
82	CHEK2	0.28532364
83	SIK2	0.27805058
84	INSRR	0.27588435
85	PIK3CA	0.26726974
86	PIM1	0.25395780
87	WNK3	0.24850604
88	PRKCG	0.24763616
89	PRKCA	0.22264695
90	MET	0.20659256
91	CSNK2A1	0.19200912
92	MKNK1	0.19177919
93	RPS6KA3	0.18529977
94	CDK7	0.17770487
95	RPS6KC1	0.15922840
96	RPS6KL1	0.15922840
97	PRKACG	0.15558081
98	STK11	0.15350474
99	RPS6KA5	0.13846477
100	AKT2	0.13638099

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	3.64069640
2	Arginine biosynthesis_Homo sapiens_hsa00220	3.01171764
3	Collecting duct acid secretion_Homo sapiens_hsa04966	2.99064560
4	Sulfur relay system_Homo sapiens_hsa04122	2.79562695
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.77042036
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.47169011
7	Sulfur metabolism_Homo sapiens_hsa00920	2.23215202
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.12810905
9	ABC transporters_Homo sapiens_hsa02010	2.11088282
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.06034135
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.99749112
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.93832848
13	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.88014799
14	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.85821900
15	Ribosome_Homo sapiens_hsa03010	1.77566324
16	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.76128864
17	GABAergic synapse_Homo sapiens_hsa04727	1.69182356
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63843327
19	Galactose metabolism_Homo sapiens_hsa00052	1.63639682
20	Parkinsons disease_Homo sapiens_hsa05012	1.63495695
21	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.60786724
22	Morphine addiction_Homo sapiens_hsa05032	1.58691839
23	Arginine and proline metabolism_Homo sapiens_hsa00330	1.58604718
24	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.51817789
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.49033200
26	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.45241306
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.45018486
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.38739667
29	Nicotine addiction_Homo sapiens_hsa05033	1.38574151
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.37975759
31	Basal transcription factors_Homo sapiens_hsa03022	1.28950464
32	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.28751154
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.28075938
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.24397390
35	Retinol metabolism_Homo sapiens_hsa00830	1.23877579
36	Huntingtons disease_Homo sapiens_hsa05016	1.22948761
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.22891331
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.22224887
39	Alzheimers disease_Homo sapiens_hsa05010	1.21481173
40	Tyrosine metabolism_Homo sapiens_hsa00350	1.21006767
41	Serotonergic synapse_Homo sapiens_hsa04726	1.19966957
42	Vibrio cholerae infection_Homo sapiens_hsa05110	1.17074161
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.15980205
44	Folate biosynthesis_Homo sapiens_hsa00790	1.11500924
45	beta-Alanine metabolism_Homo sapiens_hsa00410	1.10446455
46	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.09253713
47	Tryptophan metabolism_Homo sapiens_hsa00380	1.08988036
48	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.07329840
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.03110977
50	Butanoate metabolism_Homo sapiens_hsa00650	1.01550868
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.00926132
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.96957204
53	Proteasome_Homo sapiens_hsa03050	0.96831126
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.93027242
55	RNA degradation_Homo sapiens_hsa03018	0.91976308
56	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.89390070
57	Histidine metabolism_Homo sapiens_hsa00340	0.86546882
58	Glutathione metabolism_Homo sapiens_hsa00480	0.86362164
59	Metabolic pathways_Homo sapiens_hsa01100	0.86201429
60	Peroxisome_Homo sapiens_hsa04146	0.82575301
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.78488810
62	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.77217753
63	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.77087328
64	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.76832197
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76420120
66	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.74620200
67	Homologous recombination_Homo sapiens_hsa03440	0.73503752
68	Glutamatergic synapse_Homo sapiens_hsa04724	0.73190973
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71845804
70	Propanoate metabolism_Homo sapiens_hsa00640	0.71742778
71	Base excision repair_Homo sapiens_hsa03410	0.65251102
72	Circadian entrainment_Homo sapiens_hsa04713	0.64361374
73	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.64123679
74	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62538497
75	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.61305374
76	Fatty acid degradation_Homo sapiens_hsa00071	0.59291353
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59255171
78	Phototransduction_Homo sapiens_hsa04744	0.57627229
79	Mineral absorption_Homo sapiens_hsa04978	0.57127742
80	Bile secretion_Homo sapiens_hsa04976	0.55789231
81	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.54497708
82	Caffeine metabolism_Homo sapiens_hsa00232	0.50923332
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50381743
84	Regulation of autophagy_Homo sapiens_hsa04140	0.49234244
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.46900098
86	Fanconi anemia pathway_Homo sapiens_hsa03460	0.46832816
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.45747572
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45221747
89	Purine metabolism_Homo sapiens_hsa00230	0.44902863
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.43995951
91	Protein export_Homo sapiens_hsa03060	0.43461028
92	mRNA surveillance pathway_Homo sapiens_hsa03015	0.39766667
93	RNA transport_Homo sapiens_hsa03013	0.37086957
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36627432
95	Olfactory transduction_Homo sapiens_hsa04740	0.35617262
96	DNA replication_Homo sapiens_hsa03030	0.33976202
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.33184544
98	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.33081020
99	Taste transduction_Homo sapiens_hsa04742	0.32672053
100	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.30496603

KRT18P35

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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