ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	7.16000856
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	7.16000856
3	homocysteine metabolic process (GO:0050667)	6.91263919
4	cysteine metabolic process (GO:0006534)	5.94051579
5	folic acid-containing compound biosynthetic process (GO:0009396)	5.91505606
6	dicarboxylic acid biosynthetic process (GO:0043650)	5.48398767
7	sulfur amino acid catabolic process (GO:0000098)	5.41681973
8	regulation of plasminogen activation (GO:0010755)	5.13304446
9	DNA replication-dependent nucleosome organization (GO:0034723)	4.98971815
10	DNA replication-dependent nucleosome assembly (GO:0006335)	4.98971815
11	IMP biosynthetic process (GO:0006188)	4.77762882
12	pteridine-containing compound biosynthetic process (GO:0042559)	4.67176455
13	L-serine metabolic process (GO:0006563)	4.50940400
14	galactose catabolic process (GO:0019388)	4.41196868
15	mitochondrial RNA metabolic process (GO:0000959)	4.35195495
16	artery smooth muscle contraction (GO:0014824)	4.32508387
17	purine nucleotide salvage (GO:0032261)	4.24910594
18	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.23680081
19	sulfur amino acid biosynthetic process (GO:0000097)	4.20732797
20	positive regulation of endothelial cell differentiation (GO:0045603)	4.19525791
21	serine family amino acid biosynthetic process (GO:0009070)	4.15090322
22	xenobiotic catabolic process (GO:0042178)	4.13879748
23	desmosome organization (GO:0002934)	4.10021014
24	mitochondrial calcium ion transport (GO:0006851)	4.00246944
25	protein-cofactor linkage (GO:0018065)	3.95409734
26	alternative mRNA splicing, via spliceosome (GO:0000380)	3.94190805
27	polyamine metabolic process (GO:0006595)	3.89328164
28	primary amino compound metabolic process (GO:1901160)	3.87874650
29	IMP metabolic process (GO:0046040)	3.87848969
30	tonic smooth muscle contraction (GO:0014820)	3.79851177
31	galactose metabolic process (GO:0006012)	3.78343579
32	cellular response to electrical stimulus (GO:0071257)	3.76754077
33	rRNA methylation (GO:0031167)	3.72964442
34	protein-chromophore linkage (GO:0018298)	3.72542193
35	polyamine biosynthetic process (GO:0006596)	3.72206618
36	dicarboxylic acid catabolic process (GO:0043649)	3.69605043
37	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	3.66931608
38	vagina development (GO:0060068)	3.63528687
39	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.63143641
40	GTP biosynthetic process (GO:0006183)	3.61824270
41	L-phenylalanine metabolic process (GO:0006558)	3.61511890
42	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.61511890
43	nucleoside transmembrane transport (GO:1901642)	3.60531623
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.57545248
45	NADH dehydrogenase complex assembly (GO:0010257)	3.57545248
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.57545248
47	glutamine family amino acid biosynthetic process (GO:0009084)	3.54876925
48	L-methionine salvage (GO:0071267)	3.53969313
49	L-methionine biosynthetic process (GO:0071265)	3.53969313
50	amino acid salvage (GO:0043102)	3.53969313
51	pseudouridine synthesis (GO:0001522)	3.53195534
52	adenosine metabolic process (GO:0046085)	3.50728794
53	rRNA modification (GO:0000154)	3.46406187
54	alpha-amino acid biosynthetic process (GO:1901607)	3.46239603
55	ribosome biogenesis (GO:0042254)	3.43982821
56	negative regulation of DNA biosynthetic process (GO:2000279)	3.39923165
57	white fat cell differentiation (GO:0050872)	3.36658811
58	UTP biosynthetic process (GO:0006228)	3.34060657
59	tetrahydrofolate metabolic process (GO:0046653)	3.33915834
60	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.30176608
61	guanosine-containing compound biosynthetic process (GO:1901070)	3.29420002
62	regulation of tight junction assembly (GO:2000810)	3.23878671
63	regulation of gonadotropin secretion (GO:0032276)	3.20613532
64	folic acid-containing compound metabolic process (GO:0006760)	3.20170913
65	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	3.18113278
66	proteasome assembly (GO:0043248)	3.16951760
67	aminoglycoside antibiotic metabolic process (GO:0030647)	3.14071847
68	protein carboxylation (GO:0018214)	3.09951955
69	peptidyl-glutamic acid carboxylation (GO:0017187)	3.09951955
70	microtubule nucleation (GO:0007020)	3.08820234
71	regulation of endothelial cell differentiation (GO:0045601)	3.07259960
72	sulfur amino acid metabolic process (GO:0000096)	3.07256283
73	UTP metabolic process (GO:0046051)	3.05887297
74	regulation of bile acid biosynthetic process (GO:0070857)	3.03226322
75	water-soluble vitamin biosynthetic process (GO:0042364)	3.00612879
76	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.97600146
77	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.97384056
78	cerebellar Purkinje cell differentiation (GO:0021702)	2.95837855
79	pteridine-containing compound metabolic process (GO:0042558)	2.94911449
80	energy homeostasis (GO:0097009)	2.94013082
81	inner ear receptor cell development (GO:0060119)	2.93056459
82	cardiac right ventricle morphogenesis (GO:0003215)	2.87771172
83	tRNA modification (GO:0006400)	2.86334022
84	glutamine family amino acid catabolic process (GO:0009065)	2.85238196
85	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.80895407
86	pathway-restricted SMAD protein phosphorylation (GO:0060389)	2.79864649
87	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.79577422
88	L-phenylalanine catabolic process (GO:0006559)	2.79577422
89	regulation of sequestering of triglyceride (GO:0010889)	2.77498742
90	nucleotide transmembrane transport (GO:1901679)	2.77422138
91	positive regulation of gastrulation (GO:2000543)	2.75245481
92	serine family amino acid catabolic process (GO:0009071)	2.75039058
93	glutamate metabolic process (GO:0006536)	2.74596224
94	negative regulation of keratinocyte proliferation (GO:0010839)	2.74309169
95	protein complex biogenesis (GO:0070271)	2.73591344
96	glycoside metabolic process (GO:0016137)	2.73069056
97	glomerulus development (GO:0032835)	2.72256266
98	cellular biogenic amine biosynthetic process (GO:0042401)	2.71844393
99	hepatocyte apoptotic process (GO:0097284)	2.71275403
100	serine family amino acid metabolic process (GO:0009069)	2.71030636

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	8.88898502
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.53074896
3	E2F7_22180533_ChIP-Seq_HELA_Human	5.00563302
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.14672365
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.80790762
6	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.75627754
7	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	2.72765328
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.72402246
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.50893835
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.47657103
11	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.39513901
12	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.35164554
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.30978330
14	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.28485433
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.26855348
16	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.18375312
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14813404
18	AR_21909140_ChIP-Seq_LNCAP_Human	2.03724251
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.03235151
20	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.99466269
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.99401259
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.88286314
23	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.83214927
24	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.82703973
25	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.79461363
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.77535320
27	XRN2_22483619_ChIP-Seq_HELA_Human	1.76211606
28	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.66131544
29	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.66079884
30	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.65148412
31	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.60658133
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.60433394
33	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.56189856
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.53733987
35	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.52586007
36	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.50581703
37	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.44738511
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.41710642
39	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.40082929
40	GATA4_25053715_ChIP-Seq_YYC3_Human	1.39400334
41	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.38428232
42	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.35310647
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35154330
44	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.30544722
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27827171
46	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.26233642
47	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.25923306
48	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.25303774
49	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.25119551
50	GATA6_25053715_ChIP-Seq_YYC3_Human	1.23861585
51	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.23849747
52	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.21304286
53	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.21018980
54	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.20865905
55	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.20731625
56	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.20292067
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.16464035
58	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.16331296
59	DCP1A_22483619_ChIP-Seq_HELA_Human	1.14660267
60	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.12993481
61	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.10343537
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08247700
63	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.07517578
64	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05829145
65	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.04527833
66	P68_20966046_ChIP-Seq_HELA_Human	1.01184508
67	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.98135947
68	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.96563046
69	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.96147438
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93391726
71	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.93163150
72	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.92915455
73	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.92325761
74	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.92221712
75	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.91795845
76	BCOR_27268052_Chip-Seq_Bcells_Human	0.91673084
77	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.91641190
78	SPI1_20517297_ChIP-Seq_HL60_Human	0.89321864
79	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.86988443
80	P300_27268052_Chip-Seq_Bcells_Human	0.82337613
81	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.81257034
82	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.78456466
83	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.77532477
84	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.77379476
85	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.77014682
86	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.76913076
87	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.76302549
88	VDR_22108803_ChIP-Seq_LS180_Human	0.75188751
89	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.75059753
90	ZNF263_19887448_ChIP-Seq_K562_Human	0.74539103
91	RAC3_21632823_ChIP-Seq_H3396_Human	0.74126997
92	VDR_23849224_ChIP-Seq_CD4+_Human	0.73866904
93	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.73638016
94	KDM5A_27292631_Chip-Seq_BREAST_Human	0.73366493
95	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.72877576
96	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.72461252
97	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.72458370
98	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.71991284
99	NCOR_22424771_ChIP-Seq_293T_Human	0.71293492
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.71046673

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	6.18167901
2	MP0002139_abnormal_hepatobiliary_system	4.45329580
3	MP0004147_increased_porphyrin_level	3.77525903
4	MP0003252_abnormal_bile_duct	3.64349805
5	MP0005670_abnormal_white_adipose	3.55851599
6	MP0008875_abnormal_xenobiotic_pharmacok	3.39263840
7	MP0002736_abnormal_nociception_after	3.14109513
8	MP0003283_abnormal_digestive_organ	2.94091842
9	MP0005365_abnormal_bile_salt	2.74555862
10	MP0003890_abnormal_embryonic-extraembry	2.63991740
11	MP0005085_abnormal_gallbladder_physiolo	2.56116116
12	MP0001661_extended_life_span	2.53327377
13	MP0005646_abnormal_pituitary_gland	2.48297310
14	MP0008872_abnormal_physiological_respon	2.33397984
15	MP0002938_white_spotting	2.33202859
16	MP0008995_early_reproductive_senescence	2.31075287
17	MP0005084_abnormal_gallbladder_morpholo	2.15314663
18	MP0003806_abnormal_nucleotide_metabolis	2.13054522
19	MP0003195_calcinosis	2.12526215
20	MP0005332_abnormal_amino_acid	2.05698917
21	MP0000538_abnormal_urinary_bladder	1.95592331
22	MP0005167_abnormal_blood-brain_barrier	1.93875373
23	MP0000647_abnormal_sebaceous_gland	1.92389653
24	MP0003186_abnormal_redox_activity	1.82641351
25	MP0002138_abnormal_hepatobiliary_system	1.80470976
26	MP0001764_abnormal_homeostasis	1.68607736
27	MP0005187_abnormal_penis_morphology	1.67625561
28	MP0001968_abnormal_touch/_nociception	1.66247863
29	MP0000534_abnormal_ureter_morphology	1.63858682
30	MP0000013_abnormal_adipose_tissue	1.61536266
31	MP0003183_abnormal_peptide_metabolism	1.58917262
32	MP0010234_abnormal_vibrissa_follicle	1.56700977
33	MP0003693_abnormal_embryo_hatching	1.55192497
34	MP0009697_abnormal_copulation	1.44239614
35	MP0000566_synostosis	1.43777454
36	MP0004957_abnormal_blastocyst_morpholog	1.39917302
37	MP0002160_abnormal_reproductive_system	1.37438868
38	MP0010094_abnormal_chromosome_stability	1.36497885
39	MP0004019_abnormal_vitamin_homeostasis	1.35064930
40	MP0003111_abnormal_nucleus_morphology	1.32390266
41	MP0005319_abnormal_enzyme/_coenzyme	1.27652574
42	MP0005410_abnormal_fertilization	1.25819666
43	MP0009643_abnormal_urine_homeostasis	1.25656392
44	MP0010329_abnormal_lipoprotein_level	1.14751798
45	MP0002735_abnormal_chemical_nociception	1.11370877
46	MP0004043_abnormal_pH_regulation	1.10822578
47	MP0003786_premature_aging	1.10624231
48	MP0003315_abnormal_perineum_morphology	1.08733126
49	MP0005220_abnormal_exocrine_pancreas	1.08265791
50	MP0003942_abnormal_urinary_system	1.08063632
51	MP0001919_abnormal_reproductive_system	1.06477491
52	MP0003119_abnormal_digestive_system	1.06421922
53	MP0005636_abnormal_mineral_homeostasis	1.05471068
54	MP0006054_spinal_hemorrhage	1.03296336
55	MP0001756_abnormal_urination	1.01887424
56	MP0004885_abnormal_endolymph	1.00863977
57	MP0009046_muscle_twitch	1.00418702
58	MP0005248_abnormal_Harderian_gland	0.98599886
59	MP0001944_abnormal_pancreas_morphology	0.95953220
60	MP0005083_abnormal_biliary_tract	0.95908139
61	MP0005389_reproductive_system_phenotype	0.94585515
62	MP0004185_abnormal_adipocyte_glucose	0.93735439
63	MP0004272_abnormal_basement_membrane	0.91996433
64	MP0005386_behavior/neurological_phenoty	0.86772390
65	MP0004924_abnormal_behavior	0.86772390
66	MP0001666_abnormal_nutrient_absorption	0.85638997
67	MP0010386_abnormal_urinary_bladder	0.84688650
68	MP0002557_abnormal_social/conspecific_i	0.83558666
69	MP0000470_abnormal_stomach_morphology	0.79116859
70	MP0004233_abnormal_muscle_weight	0.77448435
71	MP0008004_abnormal_stomach_pH	0.77089987
72	MP0005377_hearing/vestibular/ear_phenot	0.76454538
73	MP0003878_abnormal_ear_physiology	0.76454538
74	MP0001340_abnormal_eyelid_morphology	0.75950204
75	MP0001730_embryonic_growth_arrest	0.74373694
76	MP0000653_abnormal_sex_gland	0.74292372
77	MP0001145_abnormal_male_reproductive	0.71169001
78	MP0002210_abnormal_sex_determination	0.70306272
79	MP0003698_abnormal_male_reproductive	0.69654163
80	MP0003699_abnormal_female_reproductive	0.69301040
81	MP0002693_abnormal_pancreas_physiology	0.68148637
82	MP0002089_abnormal_postnatal_growth/wei	0.67941692
83	MP0005376_homeostasis/metabolism_phenot	0.67435203
84	MP0003953_abnormal_hormone_level	0.66226600
85	MP0001119_abnormal_female_reproductive	0.64680522
86	MP0002132_abnormal_respiratory_system	0.64654518
87	MP0002098_abnormal_vibrissa_morphology	0.63318322
88	MP0003638_abnormal_response/metabolism_	0.62427230
89	MP0000609_abnormal_liver_physiology	0.62392239
90	MP0002161_abnormal_fertility/fecundity	0.61550766
91	MP0005584_abnormal_enzyme/coenzyme_acti	0.61409872
92	MP0002111_abnormal_tail_morphology	0.60922904
93	MP0000516_abnormal_urinary_system	0.59590237
94	MP0005367_renal/urinary_system_phenotyp	0.59590237
95	MP0001529_abnormal_vocalization	0.58603419
96	MP0001765_abnormal_ion_homeostasis	0.58506148
97	MP0003705_abnormal_hypodermis_morpholog	0.58030504
98	MP0002396_abnormal_hematopoietic_system	0.57551518
99	MP0001929_abnormal_gametogenesis	0.57501931
100	MP0003718_maternal_effect	0.57470485

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	8.52459663
2	Abnormality of alanine metabolism (HP:0010916)	8.52459663
3	Hyperalaninemia (HP:0003348)	8.52459663
4	Birth length less than 3rd percentile (HP:0003561)	6.66955541
5	Back pain (HP:0003418)	4.38348541
6	Congenital sensorineural hearing impairment (HP:0008527)	4.04726522
7	Abnormality of serum amino acid levels (HP:0003112)	4.01332251
8	Generalized aminoaciduria (HP:0002909)	3.54124337
9	Vascular calcification (HP:0004934)	3.53940392
10	Esophageal varix (HP:0002040)	3.44996940
11	Microretrognathia (HP:0000308)	3.37613453
12	Constricted visual fields (HP:0001133)	3.36537024
13	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.34667263
14	Increased serum pyruvate (HP:0003542)	3.31251336
15	Action tremor (HP:0002345)	3.25042123
16	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.20863501
17	Dysdiadochokinesis (HP:0002075)	3.14546446
18	Cardiovascular calcification (HP:0011915)	3.03537116
19	Abnormality of glycolysis (HP:0004366)	3.02922554
20	Shawl scrotum (HP:0000049)	2.99785252
21	Hepatocellular carcinoma (HP:0001402)	2.91804565
22	Breast hypoplasia (HP:0003187)	2.91791271
23	Nausea (HP:0002018)	2.91600035
24	Abnormal pancreas size (HP:0012094)	2.87320727
25	Hyperglycinemia (HP:0002154)	2.84625825
26	Patchy hypopigmentation of hair (HP:0011365)	2.80377735
27	Myocardial infarction (HP:0001658)	2.78893744
28	Abnormality of homocysteine metabolism (HP:0010919)	2.78192992
29	Homocystinuria (HP:0002156)	2.78192992
30	Long nose (HP:0003189)	2.73122113
31	Abnormality of the fetal cardiovascular system (HP:0010948)	2.72832023
32	Abnormal umbilical cord blood vessels (HP:0011403)	2.72832023
33	Single umbilical artery (HP:0001195)	2.72832023
34	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.64266983
35	Intrahepatic cholestasis (HP:0001406)	2.51300962
36	White forelock (HP:0002211)	2.47718464
37	Hypoglycemic coma (HP:0001325)	2.44516943
38	Conjunctival telangiectasia (HP:0000524)	2.44072216
39	Reduced subcutaneous adipose tissue (HP:0003758)	2.42040524
40	Genetic anticipation (HP:0003743)	2.35025414
41	Ileus (HP:0002595)	2.34611982
42	Renal cortical cysts (HP:0000803)	2.34555585
43	Horizontal nystagmus (HP:0000666)	2.33278416
44	Pendular nystagmus (HP:0012043)	2.31502439
45	Abnormality of fatty-acid metabolism (HP:0004359)	2.30611728
46	Abnormality of methionine metabolism (HP:0010901)	2.27599122
47	Large eyes (HP:0001090)	2.25135849
48	Hypolipoproteinemia (HP:0010981)	2.22798375
49	Hypoalphalipoproteinemia (HP:0003233)	2.20469151
50	Decreased subcutaneous fat (HP:0001002)	2.20171070
51	Conjugated hyperbilirubinemia (HP:0002908)	2.15478004
52	Overlapping toe (HP:0001845)	2.14627161
53	Proximal tubulopathy (HP:0000114)	2.12653511
54	Abnormality of the umbilical cord (HP:0010881)	2.12555265
55	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.12122521
56	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.10836497
57	Xanthomatosis (HP:0000991)	2.09811739
58	Toxemia of pregnancy (HP:0100603)	2.09661162
59	Pigmentary retinal degeneration (HP:0001146)	2.08971145
60	Clitoromegaly (HP:0000057)	2.08693940
61	Deep venous thrombosis (HP:0002625)	2.08295318
62	Chorioretinal atrophy (HP:0000533)	2.06111929
63	Hyperammonemia (HP:0001987)	2.04771987
64	Acute encephalopathy (HP:0006846)	2.02999761
65	Renal tubular acidosis (HP:0001947)	2.02151600
66	Abnormality of cochlea (HP:0000375)	2.01062171
67	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.00279925
68	Postural tremor (HP:0002174)	1.99236935
69	Abnormality of urine glucose concentration (HP:0011016)	1.97001046
70	Glycosuria (HP:0003076)	1.97001046
71	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.96755999
72	Cerebral edema (HP:0002181)	1.95339311
73	Micronodular cirrhosis (HP:0001413)	1.89125807
74	Hypobetalipoproteinemia (HP:0003563)	1.88344196
75	Unilateral renal agenesis (HP:0000122)	1.87570666
76	Acute necrotizing encephalopathy (HP:0006965)	1.87549421
77	Increased purine levels (HP:0004368)	1.86864241
78	Hyperuricemia (HP:0002149)	1.86864241
79	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.86844077
80	Dysmetric saccades (HP:0000641)	1.86591380
81	Abnormality of pyrimidine metabolism (HP:0004353)	1.85988952
82	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.82571083
83	Dicarboxylic aciduria (HP:0003215)	1.82571083
84	Anorexia (HP:0002039)	1.80985448
85	Attenuation of retinal blood vessels (HP:0007843)	1.80782315
86	Petechiae (HP:0000967)	1.80033363
87	Lactic acidosis (HP:0003128)	1.78280500
88	Type I transferrin isoform profile (HP:0003642)	1.76243667
89	Abnormality of glycine metabolism (HP:0010895)	1.76163922
90	Abnormality of serine family amino acid metabolism (HP:0010894)	1.76163922
91	Hyperglycemia (HP:0003074)	1.73075935
92	Metabolic acidosis (HP:0001942)	1.72459512
93	Abnormal mitochondria in muscle tissue (HP:0008316)	1.71490000
94	Ureteral duplication (HP:0000073)	1.71145933
95	Arthropathy (HP:0003040)	1.67619193
96	Increased serum lactate (HP:0002151)	1.67102946
97	Lethargy (HP:0001254)	1.66458433
98	Patent foramen ovale (HP:0001655)	1.66233665
99	Diaphragmatic weakness (HP:0009113)	1.65002836
100	Cortical visual impairment (HP:0100704)	1.64764812

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	5.69375338
2	ZAK	5.29509936
3	PBK	3.64830021
4	BUB1	3.11362400
5	WNK4	2.82645642
6	EPHA2	2.76901432
7	RPS6KB2	2.76794671
8	SMG1	2.56112443
9	CDK9	2.53191030
10	ACVR1B	2.52070639
11	VRK1	2.40092780
12	MAP2K3	2.39700513
13	MAP3K3	2.37105566
14	FER	2.36314765
15	LMTK2	1.83154327
16	PAK4	1.82331549
17	AURKA	1.76336379
18	VRK2	1.73523852
19	CCNB1	1.65777094
20	RPS6KA5	1.55419045
21	FGR	1.49223183
22	PDK2	1.47793602
23	STK39	1.35330433
24	TNIK	1.27878674
25	DAPK3	1.27288788
26	PTK6	1.25387141
27	CDC7	1.13607011
28	ERBB2	1.04650345
29	STK4	1.03984142
30	FES	1.02518548
31	JAK3	1.01832336
32	AKT2	0.98720118
33	OXSR1	0.98231064
34	GRK1	0.96974842
35	TAF1	0.95338041
36	MAP2K1	0.92884336
37	AURKB	0.92016979
38	NEK1	0.91751322
39	CAMK2G	0.85503613
40	CSNK1G3	0.82276238
41	CAMK1	0.82138279
42	CSNK1A1	0.79583969
43	SGK223	0.76668758
44	SGK494	0.76668758
45	FRK	0.76256906
46	MYLK	0.75973414
47	BLK	0.74300884
48	CAMK2B	0.73167985
49	MST4	0.72469038
50	CHEK2	0.72047893
51	CAMK2D	0.71916550
52	ADRBK2	0.71148564
53	TTK	0.68236470
54	PRKCD	0.68220258
55	FGFR4	0.65085534
56	ABL2	0.64503328
57	SGK2	0.63267455
58	NME2	0.62829108
59	SGK3	0.62064447
60	NUAK1	0.61745628
61	ADRBK1	0.60290762
62	PKN1	0.59320853
63	CSNK1A1L	0.57241934
64	NTRK2	0.56893738
65	ATR	0.55067676
66	PAK1	0.54694407
67	PRKCG	0.54312394
68	PLK1	0.53186759
69	CSNK1G1	0.52923936
70	BMPR1B	0.51589248
71	CSNK1G2	0.48947847
72	PRKCE	0.48802658
73	PRKCA	0.47688322
74	NTRK3	0.45936830
75	CHEK1	0.44969350
76	DYRK2	0.43236332
77	BMX	0.39032338
78	CAMK1D	0.38918653
79	CAMK2A	0.38238305
80	WEE1	0.37746320
81	CAMK4	0.36853476
82	CDK7	0.36708775
83	MAP3K12	0.35904501
84	PRKAA1	0.34261877
85	PRKCI	0.33914394
86	MAPKAPK3	0.33698725
87	DAPK1	0.32975066
88	STK16	0.30263246
89	GSK3A	0.29610160
90	BCKDK	0.28940710
91	PIM1	0.27831847
92	MST1R	0.27590958
93	UHMK1	0.27109761
94	IKBKB	0.26456033
95	CDK6	0.25675963
96	LIMK1	0.25154488
97	PRKCQ	0.24887811
98	CSNK1E	0.24443147
99	EIF2AK2	0.23211816
100	EGFR	0.22122898

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	4.00459828
2	Arginine biosynthesis_Homo sapiens_hsa00220	3.76762198
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.28275271
4	Alcoholism_Homo sapiens_hsa05034	3.01725073
5	Sulfur metabolism_Homo sapiens_hsa00920	2.95014098
6	Sulfur relay system_Homo sapiens_hsa04122	2.87287843
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.80433909
8	One carbon pool by folate_Homo sapiens_hsa00670	2.70343548
9	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.51278804
10	Proteasome_Homo sapiens_hsa03050	2.29192228
11	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.19181627
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.12623820
13	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.12062051
14	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.11400365
15	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	2.00682803
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.94907130
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.85777641
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.82704824
19	DNA replication_Homo sapiens_hsa03030	1.65110040
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.59560418
21	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.56779874
22	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.48278313
23	Glutathione metabolism_Homo sapiens_hsa00480	1.47159368
24	Oxidative phosphorylation_Homo sapiens_hsa00190	1.37461607
25	Galactose metabolism_Homo sapiens_hsa00052	1.29617558
26	Vibrio cholerae infection_Homo sapiens_hsa05110	1.29436566
27	Fat digestion and absorption_Homo sapiens_hsa04975	1.24751795
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.24544025
29	Carbon metabolism_Homo sapiens_hsa01200	1.21980778
30	Arginine and proline metabolism_Homo sapiens_hsa00330	1.20660796
31	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.20439823
32	Peroxisome_Homo sapiens_hsa04146	1.13612844
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11076418
34	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.07492602
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.03969905
36	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.03799833
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.01674501
38	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.01241949
39	Base excision repair_Homo sapiens_hsa03410	0.96068742
40	Viral carcinogenesis_Homo sapiens_hsa05203	0.94289313
41	Histidine metabolism_Homo sapiens_hsa00340	0.93626432
42	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.92390045
43	Parkinsons disease_Homo sapiens_hsa05012	0.91988085
44	Fatty acid elongation_Homo sapiens_hsa00062	0.91800425
45	Mismatch repair_Homo sapiens_hsa03430	0.90906705
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90196759
47	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.89861514
48	ABC transporters_Homo sapiens_hsa02010	0.87108107
49	Retinol metabolism_Homo sapiens_hsa00830	0.83340664
50	RNA polymerase_Homo sapiens_hsa03020	0.82493284
51	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.81879294
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.81300347
53	Homologous recombination_Homo sapiens_hsa03440	0.80282818
54	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.79857109
55	Phenylalanine metabolism_Homo sapiens_hsa00360	0.79394568
56	Pentose phosphate pathway_Homo sapiens_hsa00030	0.79018195
57	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.77230754
58	Caffeine metabolism_Homo sapiens_hsa00232	0.75340562
59	GABAergic synapse_Homo sapiens_hsa04727	0.74756125
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74727270
61	Metabolic pathways_Homo sapiens_hsa01100	0.74561011
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74175442
63	Spliceosome_Homo sapiens_hsa03040	0.73476431
64	RNA transport_Homo sapiens_hsa03013	0.72706067
65	Tyrosine metabolism_Homo sapiens_hsa00350	0.72426919
66	Fatty acid degradation_Homo sapiens_hsa00071	0.71619821
67	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.71152113
68	Huntingtons disease_Homo sapiens_hsa05016	0.70760593
69	Butanoate metabolism_Homo sapiens_hsa00650	0.68990941
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.68320025
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.67679363
72	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.67445788
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.65967873
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64253883
75	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.63579075
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.62170595
77	Other glycan degradation_Homo sapiens_hsa00511	0.62061637
78	Nicotine addiction_Homo sapiens_hsa05033	0.61387155
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60876920
80	Taste transduction_Homo sapiens_hsa04742	0.59699993
81	Folate biosynthesis_Homo sapiens_hsa00790	0.59563712
82	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.57895975
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.56140230
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54198202
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53210881
86	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.51498905
87	Purine metabolism_Homo sapiens_hsa00230	0.51460699
88	Complement and coagulation cascades_Homo sapiens_hsa04610	0.51248492
89	Propanoate metabolism_Homo sapiens_hsa00640	0.47543772
90	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.43903003
91	Thyroid cancer_Homo sapiens_hsa05216	0.43551691
92	Morphine addiction_Homo sapiens_hsa05032	0.39583267
93	Ribosome_Homo sapiens_hsa03010	0.37796894
94	Linoleic acid metabolism_Homo sapiens_hsa00591	0.37609285
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.35702133
96	Bile secretion_Homo sapiens_hsa04976	0.35002980
97	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.34993006
98	Alzheimers disease_Homo sapiens_hsa05010	0.34292058
99	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.33691150
100	PPAR signaling pathway_Homo sapiens_hsa03320	0.32801727

KRT18P36

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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