ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA strand renaturation (GO:0000733)	7.41365828
2	meiotic chromosome segregation (GO:0045132)	6.66151154
3	somatic diversification of immune receptors via somatic mutation (GO:0002566)	6.45778364
4	somatic hypermutation of immunoglobulin genes (GO:0016446)	6.45778364
5	heme transport (GO:0015886)	5.92857142
6	GMP metabolic process (GO:0046037)	5.24088297
7	sphingomyelin metabolic process (GO:0006684)	5.03294356
8	male sex determination (GO:0030238)	5.01040682
9	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	4.95560834
10	response to pheromone (GO:0019236)	4.94744016
11	pericardium development (GO:0060039)	4.88402725
12	cell wall macromolecule catabolic process (GO:0016998)	4.87534546
13	histone H2A acetylation (GO:0043968)	4.83951921
14	nucleoside transmembrane transport (GO:1901642)	4.82524453
15	ubiquinone biosynthetic process (GO:0006744)	4.77295914
16	sex determination (GO:0007530)	4.76281335
17	N-terminal protein amino acid modification (GO:0031365)	4.76185400
18	inositol phosphate catabolic process (GO:0071545)	4.73808059
19	quinone biosynthetic process (GO:1901663)	4.73164233
20	adenine nucleotide transport (GO:0051503)	4.71448643
21	lung-associated mesenchyme development (GO:0060484)	4.64939693
22	cellular response to ATP (GO:0071318)	4.63126703
23	iron coordination entity transport (GO:1901678)	4.56474110
24	N-terminal protein amino acid acetylation (GO:0006474)	4.52470072
25	lysine catabolic process (GO:0006554)	4.49781550
26	lysine metabolic process (GO:0006553)	4.49781550
27	respiratory chain complex IV assembly (GO:0008535)	4.45203310
28	intraciliary transport (GO:0042073)	4.44148929
29	terpenoid biosynthetic process (GO:0016114)	4.38355936
30	rRNA methylation (GO:0031167)	4.36318922
31	negative regulation of cell aging (GO:0090344)	4.33976846
32	purine ribonucleotide transport (GO:0015868)	4.25890092
33	GDP-mannose metabolic process (GO:0019673)	4.24661745
34	positive regulation of DNA-templated transcription, initiation (GO:2000144)	4.19836459
35	ubiquinone metabolic process (GO:0006743)	4.18103222
36	negative regulation of protein localization to cell surface (GO:2000009)	4.11153206
37	nucleotide transmembrane transport (GO:1901679)	4.09466764
38	diterpenoid biosynthetic process (GO:0016102)	4.05480426
39	cell wall macromolecule metabolic process (GO:0044036)	4.02655010
40	rRNA modification (GO:0000154)	4.00704159
41	regulation of timing of cell differentiation (GO:0048505)	3.93528636
42	retinal ganglion cell axon guidance (GO:0031290)	3.92210716
43	cardiovascular system development (GO:0072358)	3.86470611
44	purine nucleotide transport (GO:0015865)	3.64670595
45	regulation of development, heterochronic (GO:0040034)	3.60250532
46	lens fiber cell differentiation (GO:0070306)	3.59429559
47	adenosine receptor signaling pathway (GO:0001973)	3.56015091
48	proteasome assembly (GO:0043248)	3.55426630
49	nucleoside transport (GO:0015858)	3.54455226
50	polyol catabolic process (GO:0046174)	3.53520017
51	anterograde synaptic vesicle transport (GO:0048490)	3.53338600
52	mitotic cell cycle arrest (GO:0071850)	3.51725250
53	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.47683380
54	protein sumoylation (GO:0016925)	3.42808972
55	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.39899171
56	pseudouridine synthesis (GO:0001522)	3.39130427
57	tongue development (GO:0043586)	3.35860145
58	cytochrome complex assembly (GO:0017004)	3.28362652
59	regulation of skeletal muscle contraction (GO:0014819)	3.25440161
60	aspartate family amino acid catabolic process (GO:0009068)	3.23456857
61	DNA replication checkpoint (GO:0000076)	3.22848510
62	macrophage chemotaxis (GO:0048246)	3.18626451
63	tRNA modification (GO:0006400)	3.18431907
64	kinetochore assembly (GO:0051382)	3.15342238
65	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	3.12876916
66	protein localization to cilium (GO:0061512)	3.07700330
67	peristalsis (GO:0030432)	3.06669620
68	kinetochore organization (GO:0051383)	3.06616669
69	embryonic body morphogenesis (GO:0010172)	3.03601868
70	termination of RNA polymerase III transcription (GO:0006386)	3.03115849
71	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.03115849
72	regulation of acrosome reaction (GO:0060046)	3.01947266
73	regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)	3.01939061
74	appendage development (GO:0048736)	3.01480906
75	limb development (GO:0060173)	3.01480906
76	positive regulation of heat generation (GO:0031652)	2.98186402
77	replication fork processing (GO:0031297)	2.96911371
78	artery smooth muscle contraction (GO:0014824)	2.96288447
79	ketone biosynthetic process (GO:0042181)	2.95984469
80	nodal signaling pathway (GO:0038092)	2.92829290
81	negative chemotaxis (GO:0050919)	2.91431215
82	behavioral response to nicotine (GO:0035095)	2.89045175
83	regulation of heat generation (GO:0031650)	2.87654140
84	ephrin receptor signaling pathway (GO:0048013)	2.85714521
85	cofactor transport (GO:0051181)	2.84589124
86	negative regulation of dendrite development (GO:2000171)	2.84414070
87	myoblast differentiation (GO:0045445)	2.81170722
88	regulation of cellular respiration (GO:0043457)	2.80807100
89	tryptophan metabolic process (GO:0006568)	2.78365722
90	negative regulation of astrocyte differentiation (GO:0048712)	2.75809842
91	ribosome biogenesis (GO:0042254)	2.74049840
92	cytokinetic process (GO:0032506)	2.73242077
93	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.72096636
94	phasic smooth muscle contraction (GO:0014821)	2.70205425
95	piRNA metabolic process (GO:0034587)	2.66826689
96	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.66449304
97	positive regulation of meiosis (GO:0045836)	2.66334983
98	protein carboxylation (GO:0018214)	2.65859211
99	peptidyl-glutamic acid carboxylation (GO:0017187)	2.65859211
100	retinal metabolic process (GO:0042574)	2.63979118

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.23075382
2	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	4.20213977
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.91913909
4	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	3.72544798
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.62986881
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.57396801
7	VDR_22108803_ChIP-Seq_LS180_Human	3.48804904
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.20903465
9	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08360085
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.07795217
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.03743559
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.79062401
13	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.76241105
14	XRN2_22483619_ChIP-Seq_HELA_Human	2.65066534
15	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.55878335
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.46804912
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.39599488
18	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.34756941
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.30331851
20	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.23722356
21	GABP_19822575_ChIP-Seq_HepG2_Human	2.08951311
22	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.07006339
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.03736836
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.98876908
25	EWS_26573619_Chip-Seq_HEK293_Human	1.96015735
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.85853187
27	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.82724304
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.82358529
29	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.73794831
30	GATA1_22025678_ChIP-Seq_K562_Human	1.72192047
31	P68_20966046_ChIP-Seq_HELA_Human	1.71724553
32	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.68009777
33	E2F1_20622854_ChIP-Seq_HELA_Human	1.65959373
34	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.65420876
35	DCP1A_22483619_ChIP-Seq_HELA_Human	1.59372123
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.55766791
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.54977059
38	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.52825856
39	VDR_21846776_ChIP-Seq_THP-1_Human	1.52711008
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.52298331
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.50585718
42	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.50217572
43	MAF_26560356_Chip-Seq_TH2_Human	1.47253615
44	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.44131286
45	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.43235298
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42769935
47	FUS_26573619_Chip-Seq_HEK293_Human	1.42117122
48	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.40406794
49	PHF8_20622854_ChIP-Seq_HELA_Human	1.39734112
50	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.38657066
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36442403
52	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.35279439
53	BCOR_27268052_Chip-Seq_Bcells_Human	1.30984586
54	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.27022893
55	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.25408575
56	TTF2_22483619_ChIP-Seq_HELA_Human	1.25039971
57	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.23490138
58	ERA_21632823_ChIP-Seq_H3396_Human	1.22276784
59	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.17295626
60	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.17143401
61	CTCF_27219007_Chip-Seq_Bcells_Human	1.15194735
62	BCL6_27268052_Chip-Seq_Bcells_Human	1.14265674
63	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.13755802
64	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13709721
65	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.11536599
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.10754396
67	P53_21459846_ChIP-Seq_SAOS-2_Human	1.08961957
68	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.07695028
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.05905896
70	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.05774957
71	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04553345
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04418806
73	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.04281246
74	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.03307244
75	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02493385
76	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.02022060
77	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.01557759
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01554351
79	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.01399771
80	CTCF_21964334_Chip-Seq_Bcells_Human	0.99684308
81	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.98645841
82	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.98484795
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.98028491
84	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.98018545
85	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.95489989
86	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.95418917
87	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.95076870
88	ATF3_27146783_Chip-Seq_COLON_Human	0.93234492
89	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.92922355
90	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.92304937
91	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.89706597
92	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.88945616
93	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.88434368
94	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.87534410
95	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.86730941
96	CTCF_20526341_ChIP-Seq_ESCs_Human	0.82969538
97	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.82743635
98	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.82526237
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.82508640
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.81808084

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	8.60059289
2	MP0005171_absent_coat_pigmentation	5.14024550
3	MP0003693_abnormal_embryo_hatching	4.61811213
4	MP0005174_abnormal_tail_pigmentation	3.72831429
5	MP0001986_abnormal_taste_sensitivity	3.68815159
6	MP0003136_yellow_coat_color	3.18125260
7	MP0008057_abnormal_DNA_replication	3.01993415
8	MP0005423_abnormal_somatic_nervous	3.01017241
9	MP0000428_abnormal_craniofacial_morphol	2.24448117
10	MP0010094_abnormal_chromosome_stability	2.08709360
11	MP0001188_hyperpigmentation	2.04380283
12	MP0008875_abnormal_xenobiotic_pharmacok	2.03350472
13	MP0003111_abnormal_nucleus_morphology	1.94695482
14	MP0000383_abnormal_hair_follicle	1.87950311
15	MP0008058_abnormal_DNA_repair	1.83927358
16	MP0001968_abnormal_touch/_nociception	1.73754577
17	MP0001299_abnormal_eye_distance/	1.72890011
18	MP0004019_abnormal_vitamin_homeostasis	1.71616233
19	MP0001764_abnormal_homeostasis	1.70689216
20	MP0003567_abnormal_fetal_cardiomyocyte	1.67101452
21	MP0002653_abnormal_ependyma_morphology	1.66456527
22	MP0003937_abnormal_limbs/digits/tail_de	1.64506013
23	MP0002736_abnormal_nociception_after	1.62115930
24	MP0008789_abnormal_olfactory_epithelium	1.53706131
25	MP0005083_abnormal_biliary_tract	1.53306659
26	MP0002938_white_spotting	1.51570592
27	MP0002102_abnormal_ear_morphology	1.39196732
28	MP0005365_abnormal_bile_salt	1.37089851
29	MP0000049_abnormal_middle_ear	1.34926862
30	MP0004197_abnormal_fetal_growth/weight/	1.32950515
31	MP0001756_abnormal_urination	1.28974760
32	MP0004957_abnormal_blastocyst_morpholog	1.28584242
33	MP0006292_abnormal_olfactory_placode	1.26111168
34	MP0009697_abnormal_copulation	1.21271342
35	MP0005330_cardiomyopathy	1.20935432
36	MP0002210_abnormal_sex_determination	1.20542972
37	MP0002098_abnormal_vibrissa_morphology	1.19787287
38	MP0010678_abnormal_skin_adnexa	1.15441252
39	MP0002233_abnormal_nose_morphology	1.13763126
40	MP0005084_abnormal_gallbladder_morpholo	1.13150703
41	MP0005646_abnormal_pituitary_gland	1.10800209
42	MP0000427_abnormal_hair_cycle	1.06190124
43	MP0003115_abnormal_respiratory_system	1.03178407
44	MP0005076_abnormal_cell_differentiation	1.00392142
45	MP0003011_delayed_dark_adaptation	0.98254464
46	MP0003195_calcinosis	0.97647408
47	MP0005253_abnormal_eye_physiology	0.97357061
48	MP0009931_abnormal_skin_appearance	0.95119553
49	MP0000372_irregular_coat_pigmentation	0.93577545
50	MP0001666_abnormal_nutrient_absorption	0.88903251
51	MP0003943_abnormal_hepatobiliary_system	0.88866614
52	MP0003755_abnormal_palate_morphology	0.88222513
53	MP0005551_abnormal_eye_electrophysiolog	0.88028558
54	MP0000631_abnormal_neuroendocrine_gland	0.87955193
55	MP0000538_abnormal_urinary_bladder	0.87198689
56	MP0005394_taste/olfaction_phenotype	0.86141782
57	MP0005499_abnormal_olfactory_system	0.86141782
58	MP0002638_abnormal_pupillary_reflex	0.86094445
59	MP0001145_abnormal_male_reproductive	0.85837408
60	MP0003119_abnormal_digestive_system	0.85795781
61	MP0001502_abnormal_circadian_rhythm	0.85394119
62	MP0000751_myopathy	0.83514804
63	MP0003938_abnormal_ear_development	0.82908829
64	MP0005332_abnormal_amino_acid	0.82531906
65	MP0000015_abnormal_ear_pigmentation	0.81022023
66	MP0000647_abnormal_sebaceous_gland	0.80293245
67	MP0005409_darkened_coat_color	0.79844439
68	MP0003935_abnormal_craniofacial_develop	0.79785193
69	MP0003121_genomic_imprinting	0.79532476
70	MP0003718_maternal_effect	0.78637023
71	MP0010386_abnormal_urinary_bladder	0.77239386
72	MP0001661_extended_life_span	0.76596537
73	MP0002928_abnormal_bile_duct	0.76267109
74	MP0005391_vision/eye_phenotype	0.75589193
75	MP0000026_abnormal_inner_ear	0.75074834
76	MP0005584_abnormal_enzyme/coenzyme_acti	0.74705159
77	MP0002277_abnormal_respiratory_mucosa	0.72450586
78	MP0000653_abnormal_sex_gland	0.70867654
79	MP0003878_abnormal_ear_physiology	0.69422058
80	MP0005377_hearing/vestibular/ear_phenot	0.69422058
81	MP0005670_abnormal_white_adipose	0.68832281
82	MP0003936_abnormal_reproductive_system	0.68803549
83	MP0001765_abnormal_ion_homeostasis	0.67732716
84	MP0002735_abnormal_chemical_nociception	0.67403878
85	MP0001963_abnormal_hearing_physiology	0.65532269
86	MP0000750_abnormal_muscle_regeneration	0.64812841
87	MP0008872_abnormal_physiological_respon	0.63559958
88	MP0001697_abnormal_embryo_size	0.63195797
89	MP0001944_abnormal_pancreas_morphology	0.62716038
90	MP0000367_abnormal_coat/_hair	0.62659647
91	MP0001664_abnormal_digestion	0.61726057
92	MP0001929_abnormal_gametogenesis	0.59746375
93	MP0001324_abnormal_eye_pigmentation	0.59446278
94	MP0002160_abnormal_reproductive_system	0.57732041
95	MP0009115_abnormal_fat_cell	0.56302637
96	MP0001486_abnormal_startle_reflex	0.55517558
97	MP0001672_abnormal_embryogenesis/_devel	0.55139249
98	MP0005380_embryogenesis_phenotype	0.55139249
99	MP0004133_heterotaxia	0.54005662
100	MP0002111_abnormal_tail_morphology	0.53952122

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intestinal atresia (HP:0011100)	7.23047266
2	Rectovaginal fistula (HP:0000143)	4.71426343
3	Rectal fistula (HP:0100590)	4.71426343
4	Mesangial abnormality (HP:0001966)	4.62518859
5	Rib fusion (HP:0000902)	4.25574893
6	Epidermoid cyst (HP:0200040)	4.18719234
7	Vaginal fistula (HP:0004320)	4.17670772
8	Intestinal fistula (HP:0100819)	4.15884877
9	Facial hemangioma (HP:0000329)	3.69301929
10	Chronic hepatic failure (HP:0100626)	3.62151852
11	Annular pancreas (HP:0001734)	3.58839717
12	Subaortic stenosis (HP:0001682)	3.55645389
13	Abnormality of the left ventricular outflow tract (HP:0011103)	3.55645389
14	Bony spicule pigmentary retinopathy (HP:0007737)	3.52494743
15	Attenuation of retinal blood vessels (HP:0007843)	3.51623650
16	Chorioretinal atrophy (HP:0000533)	3.50353681
17	Testicular atrophy (HP:0000029)	3.47501989
18	Lipid accumulation in hepatocytes (HP:0006561)	3.29345104
19	Aplasia of the musculature (HP:0100854)	3.27877280
20	Gastrointestinal atresia (HP:0002589)	3.26158830
21	Ependymoma (HP:0002888)	3.24338682
22	Abnormal drinking behavior (HP:0030082)	3.23981929
23	Polydipsia (HP:0001959)	3.23981929
24	Respiratory difficulties (HP:0002880)	3.23132508
25	Increased hepatocellular lipid droplets (HP:0006565)	3.21328086
26	Congenital stationary night blindness (HP:0007642)	3.13310488
27	Chin dimple (HP:0010751)	2.97183556
28	Capillary hemangiomas (HP:0005306)	2.96719248
29	Abnormality of the aortic arch (HP:0012303)	2.93719121
30	Pendular nystagmus (HP:0012043)	2.93333501
31	Abnormal lung lobation (HP:0002101)	2.82432206
32	Renal Fanconi syndrome (HP:0001994)	2.81730599
33	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.79790372
34	Agnosia (HP:0010524)	2.78313948
35	Rhabdomyosarcoma (HP:0002859)	2.73584765
36	Abnormality of the phalanges of the hallux (HP:0010057)	2.71075576
37	Toxemia of pregnancy (HP:0100603)	2.68547120
38	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.67357933
39	Humeroradial synostosis (HP:0003041)	2.65118745
40	Synostosis involving the elbow (HP:0003938)	2.65118745
41	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.64533127
42	Absent radius (HP:0003974)	2.60233713
43	Tubular atrophy (HP:0000092)	2.58677849
44	Amniotic constriction ring (HP:0009775)	2.57955314
45	Abnormality of placental membranes (HP:0011409)	2.57955314
46	Basal cell carcinoma (HP:0002671)	2.56677406
47	Abnormality of lateral ventricle (HP:0030047)	2.53507927
48	Abnormality of the astrocytes (HP:0100707)	2.52813764
49	Astrocytoma (HP:0009592)	2.52813764
50	Congenital malformation of the right heart (HP:0011723)	2.49659078
51	Double outlet right ventricle (HP:0001719)	2.49659078
52	Aplasia involving forearm bones (HP:0009822)	2.45604403
53	Absent forearm bone (HP:0003953)	2.45604403
54	Hereditary nonpolyposis colorectal carcinoma (HP:0006716)	2.45415927
55	Polyuria (HP:0000103)	2.40272355
56	Cerebellar dysplasia (HP:0007033)	2.36170446
57	Poikiloderma (HP:0001029)	2.34099406
58	Patellar aplasia (HP:0006443)	2.32817818
59	Sleep apnea (HP:0010535)	2.28529886
60	Nephronophthisis (HP:0000090)	2.22294155
61	Oligodactyly (HP:0012165)	2.18018658
62	Medulloblastoma (HP:0002885)	2.17775203
63	Birth length less than 3rd percentile (HP:0003561)	2.17473662
64	Tubulointerstitial nephritis (HP:0001970)	2.14745255
65	Decreased central vision (HP:0007663)	2.14328389
66	Coarctation of aorta (HP:0001680)	2.13816947
67	Severe visual impairment (HP:0001141)	2.12146998
68	Aplasia/Hypoplasia of the patella (HP:0006498)	2.11800738
69	Gastrointestinal carcinoma (HP:0002672)	2.10371360
70	Malignant gastrointestinal tract tumors (HP:0006749)	2.10371360
71	Biliary tract neoplasm (HP:0100574)	2.07517389
72	Dyschromatopsia (HP:0007641)	2.05308970
73	Neoplasm of the colon (HP:0100273)	2.05005186
74	Abnormality of the intrinsic pathway (HP:0010989)	2.04327321
75	Abnormal urine output (HP:0012590)	2.00137078
76	Abnormality of midbrain morphology (HP:0002418)	2.00107114
77	Molar tooth sign on MRI (HP:0002419)	2.00107114
78	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.98372171
79	Absent thumb (HP:0009777)	1.98244272
80	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.98076948
81	Increased intramyocellular lipid droplets (HP:0012240)	1.97915847
82	Aplasia/hypoplasia of the humerus (HP:0006507)	1.95611547
83	Amblyopia (HP:0000646)	1.95430683
84	Abnormality of renal resorption (HP:0011038)	1.94936738
85	Malignant hyperthermia (HP:0002047)	1.93766524
86	Spastic diplegia (HP:0001264)	1.93363883
87	Hypophosphatemic rickets (HP:0004912)	1.92753516
88	Ulnar bowing (HP:0003031)	1.91367624
89	Akinesia (HP:0002304)	1.90425340
90	Abnormal biliary tract physiology (HP:0012439)	1.89067301
91	Bile duct proliferation (HP:0001408)	1.89067301
92	Increased muscle lipid content (HP:0009058)	1.88226142
93	Glioma (HP:0009733)	1.87612899
94	Nephroblastoma (Wilms tumor) (HP:0002667)	1.86914742
95	Optic nerve coloboma (HP:0000588)	1.86043510
96	Growth hormone deficiency (HP:0000824)	1.84821821
97	Prolonged partial thromboplastin time (HP:0003645)	1.84430214
98	Popliteal pterygium (HP:0009756)	1.83658263
99	Abnormality of renal excretion (HP:0011036)	1.82653997
100	Oligodactyly (hands) (HP:0001180)	1.81753874

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.50392059
2	ACVR1B	4.18073130
3	BMPR1B	2.99237682
4	MAPK15	2.91790361
5	WNK4	2.78046312
6	MELK	2.21373418
7	VRK2	2.06132299
8	MST4	2.05219157
9	STK16	11.6666411
10	VRK1	1.96432105
11	WEE1	1.81798739
12	STK39	1.75292822
13	SRPK1	1.73380748
14	NME1	1.71702721
15	MAP2K1	1.65290652
16	NUAK1	1.53551292
17	ZAK	1.46213109
18	TAF1	1.36530013
19	TGFBR1	1.36504929
20	OXSR1	1.33698381
21	MUSK	1.25989102
22	AKT3	1.15613847
23	MAP2K2	1.11380980
24	TRIM28	1.10393925
25	MAP3K13	1.07121601
26	PBK	1.02455906
27	TLK1	0.93973990
28	EPHA2	0.88346321
29	SMG1	0.87219240
30	MAP3K7	0.86584288
31	NTRK3	0.84887082
32	PKN2	0.76029779
33	CHUK	0.74518690
34	ADRBK2	0.72188202
35	BLK	0.68469033
36	ERBB3	0.67749158
37	IRAK2	0.67052070
38	PDK2	0.66563904
39	ADRBK1	0.65968125
40	FLT3	0.63389433
41	GRK5	0.59121151
42	GRK6	0.57945480
43	CHEK2	0.53531147
44	PIK3CA	0.51888272
45	RPS6KB2	0.49958779
46	GRK1	0.49420975
47	ABL2	0.49102518
48	PRKCQ	0.48316298
49	PLK3	0.45418744
50	CDC7	0.41450447
51	ATR	0.38624731
52	FGR	0.37783030
53	MAP3K5	0.34302867
54	TNK2	0.34031756
55	CAMK4	0.32987591
56	MAP2K6	0.31712938
57	DYRK2	0.31199547
58	KSR1	0.30860631
59	MAPKAPK5	0.30724130
60	PIM2	0.30344581
61	STK11	0.28993292
62	CCNB1	0.28924539
63	RPS6KA5	0.28170901
64	PDPK1	0.27880813
65	PIM1	0.26789712
66	PRKCI	0.26501886
67	AURKA	0.26122708
68	PLK1	0.25582806
69	CDK7	0.25308323
70	PRKCZ	0.24434597
71	TESK2	0.23483395
72	RET	0.23380562
73	LATS1	0.23343661
74	PINK1	0.21302613
75	CHEK1	0.20842145
76	MARK3	0.20655842
77	BCKDK	0.20228583
78	FRK	0.18893737
79	DAPK3	0.18202880
80	IGF1R	0.16945462
81	DYRK1A	0.16915331
82	PRKCE	0.16387891
83	RPS6KB1	0.15866193
84	CDK4	0.14933428
85	PRKCD	0.14769157
86	CSNK1G3	0.13465433
87	MET	0.13129885
88	DAPK2	0.12590942
89	AKT1	0.12441110
90	PHKG2	0.12216321
91	PHKG1	0.12216321
92	MAP2K7	0.12145435
93	CSNK1A1L	0.12065742
94	BRAF	0.12038078
95	EPHA4	0.11722574
96	ATM	0.11449590
97	CDK9	0.11089576
98	PRKG1	0.10454024
99	PRKCG	0.10450956
100	RPS6KA4	0.09232164

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	7.28064587
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	4.15607436
3	Sulfur relay system_Homo sapiens_hsa04122	3.64904539
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.69842735
5	RNA polymerase_Homo sapiens_hsa03020	2.62142206
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.58257814
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.36073955
8	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.23043439
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.13699707
10	Mismatch repair_Homo sapiens_hsa03430	2.02100867
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.00340715
12	Fatty acid degradation_Homo sapiens_hsa00071	1.56931548
13	Base excision repair_Homo sapiens_hsa03410	1.53550092
14	Lysine degradation_Homo sapiens_hsa00310	1.47044862
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.42712710
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.39680074
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39112586
18	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.36086479
19	One carbon pool by folate_Homo sapiens_hsa00670	1.35898373
20	Sphingolipid metabolism_Homo sapiens_hsa00600	1.31837960
21	Homologous recombination_Homo sapiens_hsa03440	1.30799086
22	Pyruvate metabolism_Homo sapiens_hsa00620	1.30069885
23	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.29286675
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27314033
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.22067352
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.19180639
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.18765482
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.17266693
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.12252450
30	Proteasome_Homo sapiens_hsa03050	1.11893598
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10803634
32	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.08659729
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.07917387
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.05932244
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.05439184
36	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.00327244
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.98451158
38	p53 signaling pathway_Homo sapiens_hsa04115	0.91925619
39	RNA degradation_Homo sapiens_hsa03018	0.90092332
40	RNA transport_Homo sapiens_hsa03013	0.88787871
41	Purine metabolism_Homo sapiens_hsa00230	0.88218157
42	Fat digestion and absorption_Homo sapiens_hsa04975	0.88011337
43	Circadian rhythm_Homo sapiens_hsa04710	0.85109618
44	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.83178000
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.78880555
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78614129
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.77774933
48	Protein export_Homo sapiens_hsa03060	0.76265360
49	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.75179967
50	Glucagon signaling pathway_Homo sapiens_hsa04922	0.72624784
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67671955
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.67267117
53	Metabolic pathways_Homo sapiens_hsa01100	0.66653947
54	Histidine metabolism_Homo sapiens_hsa00340	0.65937253
55	Retinol metabolism_Homo sapiens_hsa00830	0.65509975
56	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.65375913
57	Peroxisome_Homo sapiens_hsa04146	0.65345897
58	Hippo signaling pathway_Homo sapiens_hsa04390	0.64980135
59	Basal cell carcinoma_Homo sapiens_hsa05217	0.64203076
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63801550
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62787658
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.62664068
63	Nicotine addiction_Homo sapiens_hsa05033	0.61405585
64	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.60260889
65	Propanoate metabolism_Homo sapiens_hsa00640	0.59446049
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59214180
67	PPAR signaling pathway_Homo sapiens_hsa03320	0.59035315
68	Basal transcription factors_Homo sapiens_hsa03022	0.57997135
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57855882
70	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.57178222
71	Phototransduction_Homo sapiens_hsa04744	0.56597444
72	Glutathione metabolism_Homo sapiens_hsa00480	0.55748041
73	Huntingtons disease_Homo sapiens_hsa05016	0.55551427
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55421455
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.53826136
76	mRNA surveillance pathway_Homo sapiens_hsa03015	0.53264343
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51911271
78	Pancreatic secretion_Homo sapiens_hsa04972	0.51067795
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.50920506
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50878777
81	Taste transduction_Homo sapiens_hsa04742	0.50342962
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48532886
83	Cell cycle_Homo sapiens_hsa04110	0.48249098
84	DNA replication_Homo sapiens_hsa03030	0.47781660
85	Wnt signaling pathway_Homo sapiens_hsa04310	0.46959710
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45475172
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44753909
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42244340
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41614001
90	Lysosome_Homo sapiens_hsa04142	0.40042326
91	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.39488685
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38981652
93	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.37469883
94	Prostate cancer_Homo sapiens_hsa05215	0.35734731
95	ABC transporters_Homo sapiens_hsa02010	0.34526170
96	Alcoholism_Homo sapiens_hsa05034	0.34488186
97	Oxidative phosphorylation_Homo sapiens_hsa00190	0.34237164
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.34041080
99	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.28854371
100	Endometrial cancer_Homo sapiens_hsa05213	0.28680064

KRT18P37

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »