ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	7.12027436
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	7.12027436
3	homocysteine metabolic process (GO:0050667)	6.53458549
4	folic acid-containing compound biosynthetic process (GO:0009396)	6.28237247
5	cysteine metabolic process (GO:0006534)	5.85365541
6	regulation of plasminogen activation (GO:0010755)	5.16694895
7	sulfur amino acid catabolic process (GO:0000098)	5.15722481
8	L-serine metabolic process (GO:0006563)	5.13103220
9	pteridine-containing compound biosynthetic process (GO:0042559)	5.06114089
10	inner mitochondrial membrane organization (GO:0007007)	4.81985915
11	purine nucleotide salvage (GO:0032261)	4.81611390
12	mitochondrial RNA metabolic process (GO:0000959)	4.79270164
13	nucleoside transmembrane transport (GO:1901642)	4.69787541
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.69031015
15	NADH dehydrogenase complex assembly (GO:0010257)	4.69031015
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.69031015
17	desmosome organization (GO:0002934)	4.59735568
18	ribosome biogenesis (GO:0042254)	4.45824581
19	regulation of mitochondrial translation (GO:0070129)	4.43173924
20	galactose catabolic process (GO:0019388)	4.35858122
21	adenosine metabolic process (GO:0046085)	4.35825793
22	serine family amino acid biosynthetic process (GO:0009070)	4.27034789
23	protein complex biogenesis (GO:0070271)	4.20449450
24	rRNA modification (GO:0000154)	4.20260385
25	proteasome assembly (GO:0043248)	4.10820987
26	polyamine biosynthetic process (GO:0006596)	4.03616947
27	rRNA methylation (GO:0031167)	4.00126424
28	negative regulation of DNA biosynthetic process (GO:2000279)	3.99881311
29	cell proliferation in forebrain (GO:0021846)	3.98312301
30	CENP-A containing nucleosome assembly (GO:0034080)	3.97137403
31	IMP biosynthetic process (GO:0006188)	3.93049373
32	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.92452602
33	chaperone-mediated protein transport (GO:0072321)	3.91947766
34	mitochondrial respiratory chain complex assembly (GO:0033108)	3.91697637
35	nucleoside transport (GO:0015858)	3.86249363
36	galactose metabolic process (GO:0006012)	3.80553184
37	pseudouridine synthesis (GO:0001522)	3.79456329
38	chromatin remodeling at centromere (GO:0031055)	3.77278763
39	aminoglycoside antibiotic metabolic process (GO:0030647)	3.74163573
40	regulation of telomerase activity (GO:0051972)	3.63794694
41	protein-cofactor linkage (GO:0018065)	3.51983488
42	cellular component biogenesis (GO:0044085)	3.49962595
43	folic acid-containing compound metabolic process (GO:0006760)	3.48368093
44	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.47937142
45	negative regulation of keratinocyte proliferation (GO:0010839)	3.46284363
46	positive regulation of endothelial cell differentiation (GO:0045603)	3.45278631
47	GTP biosynthetic process (GO:0006183)	3.44860551
48	protein heterotetramerization (GO:0051290)	3.44407754
49	white fat cell differentiation (GO:0050872)	3.44254666
50	negative regulation of telomerase activity (GO:0051974)	3.43209262
51	glycoside metabolic process (GO:0016137)	3.40740835
52	ribonucleoprotein complex biogenesis (GO:0022613)	3.36897437
53	inner ear receptor cell development (GO:0060119)	3.36734994
54	guanosine-containing compound biosynthetic process (GO:1901070)	3.36067591
55	sulfur amino acid biosynthetic process (GO:0000097)	3.35844449
56	polyamine metabolic process (GO:0006595)	3.35680139
57	tetrahydrofolate metabolic process (GO:0046653)	3.28674987
58	IMP metabolic process (GO:0046040)	3.24824462
59	pteridine-containing compound metabolic process (GO:0042558)	3.20687836
60	transcription from mitochondrial promoter (GO:0006390)	3.19849477
61	regulation of cellular amino acid metabolic process (GO:0006521)	3.19242633
62	microtubule nucleation (GO:0007020)	3.18794473
63	heme transport (GO:0015886)	3.15390835
64	positive regulation of megakaryocyte differentiation (GO:0045654)	3.14137377
65	nucleotide salvage (GO:0043173)	3.09129355
66	alternative mRNA splicing, via spliceosome (GO:0000380)	3.09087921
67	prostaglandin biosynthetic process (GO:0001516)	3.07485477
68	prostanoid biosynthetic process (GO:0046457)	3.07485477
69	water-soluble vitamin biosynthetic process (GO:0042364)	3.07296628
70	folic acid metabolic process (GO:0046655)	3.04400652
71	UTP biosynthetic process (GO:0006228)	3.04346165
72	protein targeting to mitochondrion (GO:0006626)	3.02671175
73	tRNA modification (GO:0006400)	2.99851805
74	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.98956700
75	ribosomal small subunit assembly (GO:0000028)	2.98797505
76	tRNA processing (GO:0008033)	2.98597193
77	histone exchange (GO:0043486)	2.98303300
78	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.96433645
79	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.95418432
80	ATP hydrolysis coupled proton transport (GO:0015991)	2.95418432
81	protein maturation by protein folding (GO:0022417)	2.93917216
82	cobalamin metabolic process (GO:0009235)	2.92728298
83	UTP metabolic process (GO:0046051)	2.90953161
84	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.90386182
85	DNA replication-independent nucleosome organization (GO:0034724)	2.89999429
86	DNA replication-independent nucleosome assembly (GO:0006336)	2.89999429
87	serine family amino acid catabolic process (GO:0009071)	2.87447870
88	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.85692003
89	regulation of gonadotropin secretion (GO:0032276)	2.85221141
90	negative regulation of catenin import into nucleus (GO:0035414)	2.84901920
91	establishment of protein localization to mitochondrion (GO:0072655)	2.84425959
92	protein localization to mitochondrion (GO:0070585)	2.82513398
93	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.82303668
94	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.82303668
95	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.81079928
96	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.81079928
97	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.81079928
98	regulation of oxidative phosphorylation (GO:0002082)	2.79386909
99	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.78635526
100	DNA replication checkpoint (GO:0000076)	2.75079082

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	8.34878708
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.88403577
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.83203006
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.76944577
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.55480147
6	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.13166375
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.10728275
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.91368166
9	E2F7_22180533_ChIP-Seq_HELA_Human	2.77342945
10	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.64760613
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.56288423
12	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.53466527
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.42992406
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.38834674
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.34417950
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.33678667
17	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.29241667
18	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.28559748
19	AR_21909140_ChIP-Seq_LNCAP_Human	2.25012332
20	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.14866636
21	GABP_19822575_ChIP-Seq_HepG2_Human	2.12416853
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.08153651
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.04499639
24	XRN2_22483619_ChIP-Seq_HELA_Human	1.88981389
25	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.87361791
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.84692499
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78309646
28	ZNF263_19887448_ChIP-Seq_K562_Human	1.76201567
29	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.74753766
30	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.68723049
31	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.65828194
32	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.60567578
33	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.60427740
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.60196955
35	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.59233258
36	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.57348588
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.54940486
38	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.49688838
39	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.46106676
40	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.45471934
41	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.43492233
42	DCP1A_22483619_ChIP-Seq_HELA_Human	1.36394747
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.36340533
44	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.32762779
45	TTF2_22483619_ChIP-Seq_HELA_Human	1.30721941
46	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.27836526
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.26577680
48	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.24814383
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21242038
50	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.20603179
51	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.20418925
52	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.17103205
53	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.16670362
54	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.13874656
55	KDM5A_27292631_Chip-Seq_BREAST_Human	1.13192947
56	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.11376369
57	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.11122874
58	SOX2_18692474_ChIP-Seq_MEFs_Mouse	1.07810458
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06288632
60	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.05975293
61	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.05110564
62	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03484151
63	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.01932728
64	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.00540925
65	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.00310871
66	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.98788375
67	EOMES_21245162_ChIP-Seq_HESCs_Human	0.97800055
68	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97528864
69	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.96910080
70	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.96894541
71	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.96684640
72	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.96188561
73	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.95619362
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93351724
75	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.93337030
76	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.92947008
77	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.92817458
78	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.92284971
79	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.91459829
80	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.90183001
81	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.89975649
82	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.89549782
83	GATA4_25053715_ChIP-Seq_YYC3_Human	0.85570155
84	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.85495489
85	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.85419672
86	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.84794631
87	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.84467118
88	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.83575708
89	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.82800776
90	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.82436017
91	VDR_22108803_ChIP-Seq_LS180_Human	0.80919783
92	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.80728119
93	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.79606663
94	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.79089992
95	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.78699015
96	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.78181519
97	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.77388928
98	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.76828076
99	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.76254858
100	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.75343917

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	5.33401258
2	MP0005360_urolithiasis	4.00833934
3	MP0004147_increased_porphyrin_level	3.44947225
4	MP0003806_abnormal_nucleotide_metabolis	3.40441464
5	MP0006292_abnormal_olfactory_placode	3.17408425
6	MP0000013_abnormal_adipose_tissue	3.12418005
7	MP0005646_abnormal_pituitary_gland	2.88970061
8	MP0003186_abnormal_redox_activity	2.84590900
9	MP0003693_abnormal_embryo_hatching	2.65629916
10	MP0002938_white_spotting	2.50004779
11	MP0004185_abnormal_adipocyte_glucose	2.41319612
12	MP0008995_early_reproductive_senescence	2.29073246
13	MP0000516_abnormal_urinary_system	2.26548044
14	MP0005367_renal/urinary_system_phenotyp	2.26548044
15	MP0001661_extended_life_span	2.20330281
16	MP0003183_abnormal_peptide_metabolism	2.10213454
17	MP0002736_abnormal_nociception_after	2.06076706
18	MP0005332_abnormal_amino_acid	1.96625362
19	MP0008872_abnormal_physiological_respon	1.90948686
20	MP0000647_abnormal_sebaceous_gland	1.89120710
21	MP0003878_abnormal_ear_physiology	1.82445529
22	MP0005377_hearing/vestibular/ear_phenot	1.82445529
23	MP0002653_abnormal_ependyma_morphology	1.82112172
24	MP0002132_abnormal_respiratory_system	1.72210036
25	MP0003786_premature_aging	1.71926144
26	MP0001764_abnormal_homeostasis	1.68861820
27	MP0000566_synostosis	1.56393150
28	MP0005085_abnormal_gallbladder_physiolo	1.56285346
29	MP0005084_abnormal_gallbladder_morpholo	1.54961973
30	MP0003718_maternal_effect	1.54287209
31	MP0001485_abnormal_pinna_reflex	1.52681204
32	MP0010030_abnormal_orbit_morphology	1.50444052
33	MP0010234_abnormal_vibrissa_follicle	1.45783986
34	MP0004957_abnormal_blastocyst_morpholog	1.44619367
35	MP0002837_dystrophic_cardiac_calcinosis	1.42253795
36	MP0001293_anophthalmia	1.42148534
37	MP0008058_abnormal_DNA_repair	1.40088869
38	MP0004885_abnormal_endolymph	1.36319419
39	MP0000631_abnormal_neuroendocrine_gland	1.35760434
40	MP0002095_abnormal_skin_pigmentation	1.35248513
41	MP0009697_abnormal_copulation	1.32149252
42	MP0004019_abnormal_vitamin_homeostasis	1.31332466
43	MP0009379_abnormal_foot_pigmentation	1.30600021
44	MP0003705_abnormal_hypodermis_morpholog	1.27968616
45	MP0002139_abnormal_hepatobiliary_system	1.27178440
46	MP0002138_abnormal_hepatobiliary_system	1.20252911
47	MP0003111_abnormal_nucleus_morphology	1.19114828
48	MP0001666_abnormal_nutrient_absorption	1.16395821
49	MP0005365_abnormal_bile_salt	1.13764993
50	MP0000003_abnormal_adipose_tissue	1.13357117
51	MP0006035_abnormal_mitochondrial_morpho	1.11625850
52	MP0008875_abnormal_xenobiotic_pharmacok	1.10917140
53	MP0003315_abnormal_perineum_morphology	1.04556860
54	MP0005636_abnormal_mineral_homeostasis	1.04176709
55	MP0001944_abnormal_pancreas_morphology	1.01848270
56	MP0002210_abnormal_sex_determination	1.01598855
57	MP0000026_abnormal_inner_ear	1.00168611
58	MP0010094_abnormal_chromosome_stability	0.98414353
59	MP0008932_abnormal_embryonic_tissue	0.96853252
60	MP0000538_abnormal_urinary_bladder	0.94275693
61	MP0002277_abnormal_respiratory_mucosa	0.93804135
62	MP0005551_abnormal_eye_electrophysiolog	0.91890146
63	MP0000049_abnormal_middle_ear	0.91737078
64	MP0003942_abnormal_urinary_system	0.91032422
65	MP0003123_paternal_imprinting	0.90422066
66	MP0001756_abnormal_urination	0.89114775
67	MP0005220_abnormal_exocrine_pancreas	0.88767890
68	MP0003638_abnormal_response/metabolism_	0.86393373
69	MP0002098_abnormal_vibrissa_morphology	0.85843598
70	MP0009643_abnormal_urine_homeostasis	0.84645228
71	MP0002697_abnormal_eye_size	0.83505048
72	MP0005319_abnormal_enzyme/_coenzyme	0.83268076
73	MP0001145_abnormal_male_reproductive	0.82595152
74	MP0003077_abnormal_cell_cycle	0.82495112
75	MP0003252_abnormal_bile_duct	0.82468462
76	MP0004264_abnormal_extraembryonic_tissu	0.79943038
77	MP0002876_abnormal_thyroid_physiology	0.79797045
78	MP0004133_heterotaxia	0.79047694
79	MP0000534_abnormal_ureter_morphology	0.78060383
80	MP0004130_abnormal_muscle_cell	0.77235028
81	MP0002796_impaired_skin_barrier	0.77052953
82	MP0006036_abnormal_mitochondrial_physio	0.76745541
83	MP0000762_abnormal_tongue_morphology	0.76551109
84	MP0000579_abnormal_nail_morphology	0.76343200
85	MP0003936_abnormal_reproductive_system	0.76195856
86	MP0001963_abnormal_hearing_physiology	0.75529814
87	MP0000653_abnormal_sex_gland	0.75128119
88	MP0005083_abnormal_biliary_tract	0.74932225
89	MP0005410_abnormal_fertilization	0.73555290
90	MP0002163_abnormal_gland_morphology	0.72135163
91	MP0002295_abnormal_pulmonary_circulatio	0.69771293
92	MP0001905_abnormal_dopamine_level	0.69367070
93	MP0001968_abnormal_touch/_nociception	0.69309794
94	MP0000358_abnormal_cell_content/	0.68096358
95	MP0002160_abnormal_reproductive_system	0.67411579
96	MP0002069_abnormal_eating/drinking_beha	0.66069802
97	MP0008775_abnormal_heart_ventricle	0.65708022
98	MP0005584_abnormal_enzyme/coenzyme_acti	0.64939740
99	MP0008789_abnormal_olfactory_epithelium	0.64850607
100	MP0002282_abnormal_trachea_morphology	0.60642653

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.32916951
2	Abnormality of alanine metabolism (HP:0010916)	7.32916951
3	Hyperalaninemia (HP:0003348)	7.32916951
4	Constricted visual fields (HP:0001133)	4.25338457
5	Abnormality of serum amino acid levels (HP:0003112)	4.05593490
6	Esophageal varix (HP:0002040)	3.99736733
7	Congenital sensorineural hearing impairment (HP:0008527)	3.83178091
8	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.70926342
9	Abnormality of homocysteine metabolism (HP:0010919)	3.70857515
10	Homocystinuria (HP:0002156)	3.70857515
11	Birth length less than 3rd percentile (HP:0003561)	3.54213578
12	Abnormality of the fetal cardiovascular system (HP:0010948)	3.47989842
13	Abnormal umbilical cord blood vessels (HP:0011403)	3.47989842
14	Single umbilical artery (HP:0001195)	3.47989842
15	Action tremor (HP:0002345)	3.41064121
16	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.19891327
17	Hyperglycinemia (HP:0002154)	3.18188388
18	Acute necrotizing encephalopathy (HP:0006965)	3.08122100
19	Abnormality of the umbilical cord (HP:0010881)	2.99879206
20	Insulin-resistant diabetes mellitus (HP:0000831)	2.95329136
21	Increased serum pyruvate (HP:0003542)	2.94135312
22	Abnormal mitochondria in muscle tissue (HP:0008316)	2.93855031
23	Conjugated hyperbilirubinemia (HP:0002908)	2.82565508
24	Maternal diabetes (HP:0009800)	2.81769053
25	Acute encephalopathy (HP:0006846)	2.79672649
26	Myocardial infarction (HP:0001658)	2.77538809
27	Hypoalphalipoproteinemia (HP:0003233)	2.72122184
28	Anorexia (HP:0002039)	2.65074616
29	Lactic acidosis (HP:0003128)	2.62821707
30	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.61230441
31	Increased serum lactate (HP:0002151)	2.61030273
32	Abnormality of glycolysis (HP:0004366)	2.60675796
33	White forelock (HP:0002211)	2.59496023
34	Mitochondrial inheritance (HP:0001427)	2.53496940
35	Hepatocellular necrosis (HP:0001404)	2.52367684
36	Abnormality of methionine metabolism (HP:0010901)	2.51304391
37	Megaloblastic anemia (HP:0001889)	2.51278202
38	Ileus (HP:0002595)	2.49927951
39	Cone-rod dystrophy (HP:0000548)	2.47116842
40	Hyperuricemia (HP:0002149)	2.45465476
41	Increased purine levels (HP:0004368)	2.45465476
42	Reticulocytopenia (HP:0001896)	2.43510832
43	Poor speech (HP:0002465)	2.43173461
44	Patchy hypopigmentation of hair (HP:0011365)	2.41818264
45	Progressive macrocephaly (HP:0004481)	2.39141609
46	Nausea (HP:0002018)	2.33998615
47	Generalized aminoaciduria (HP:0002909)	2.33437749
48	Reduced subcutaneous adipose tissue (HP:0003758)	2.33296626
49	Stenosis of the external auditory canal (HP:0000402)	2.33052473
50	Methylmalonic acidemia (HP:0002912)	2.32410096
51	Spontaneous abortion (HP:0005268)	2.31167471
52	Increased CSF lactate (HP:0002490)	2.30677049
53	Lethargy (HP:0001254)	2.28896189
54	Cerebral edema (HP:0002181)	2.28708806
55	Oligomenorrhea (HP:0000876)	2.27970032
56	Adrenal hypoplasia (HP:0000835)	2.25855521
57	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.24455495
58	Metabolic acidosis (HP:0001942)	2.21313064
59	Delayed CNS myelination (HP:0002188)	2.18650079
60	Decreased subcutaneous fat (HP:0001002)	2.18111407
61	Hepatic necrosis (HP:0002605)	2.14170645
62	Macrocytic anemia (HP:0001972)	2.12269553
63	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.04643533
64	Myopathic facies (HP:0002058)	2.03321256
65	Methylmalonic aciduria (HP:0012120)	2.01868991
66	Glucose intolerance (HP:0000833)	2.01024594
67	Abnormalities of placenta or umbilical cord (HP:0001194)	2.00795698
68	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.99940995
69	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.99807224
70	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.99807224
71	Conjunctival telangiectasia (HP:0000524)	1.99588048
72	Pigmentary retinal degeneration (HP:0001146)	1.99421574
73	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.99193223
74	Spontaneous hematomas (HP:0007420)	1.97741815
75	Exercise intolerance (HP:0003546)	1.96240861
76	Median cleft lip (HP:0000161)	1.93466549
77	Abnormality of magnesium homeostasis (HP:0004921)	1.88060565
78	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.86950368
79	Pancreatitis (HP:0001733)	1.85624004
80	Renal tubular acidosis (HP:0001947)	1.85587641
81	Brittle hair (HP:0002299)	1.84196842
82	Hypolipoproteinemia (HP:0010981)	1.79974217
83	Fatigue (HP:0012378)	1.79545970
84	Intrahepatic cholestasis (HP:0001406)	1.79539859
85	Hyperphosphaturia (HP:0003109)	1.77841879
86	Impaired vibration sensation in the lower limbs (HP:0002166)	1.77204858
87	Toxemia of pregnancy (HP:0100603)	1.76992836
88	Proximal tubulopathy (HP:0000114)	1.76755023
89	Diaphragmatic weakness (HP:0009113)	1.76469459
90	Cortical visual impairment (HP:0100704)	1.76254151
91	Rough bone trabeculation (HP:0100670)	1.75690054
92	Abnormal number of erythroid precursors (HP:0012131)	1.75333150
93	Paralysis (HP:0003470)	1.73848560
94	Cerebral hypomyelination (HP:0006808)	1.72982583
95	Abnormality of serine family amino acid metabolism (HP:0010894)	1.72628415
96	Abnormality of glycine metabolism (HP:0010895)	1.72628415
97	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.72130582
98	Hypomagnesemia (HP:0002917)	1.71612374
99	Congenital ichthyosiform erythroderma (HP:0007431)	1.70818712
100	Abnormality of cells of the erythroid lineage (HP:0012130)	1.70336795

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	3.77948350
2	VRK2	3.74391633
3	MAP3K3	3.53793558
4	LMTK2	3.44768600
5	EPHA2	3.27783316
6	RPS6KB2	3.04632291
7	BUB1	3.03461586
8	PBK	2.85944862
9	MAP2K3	2.58329715
10	MST4	2.33695431
11	CDC7	2.03443537
12	CDK9	1.94665745
13	PAK4	1.92605666
14	ACVR1B	1.89963425
15	STK16	1.75584452
16	NEK1	1.75497358
17	PRKCI	1.72418137
18	ZAK	1.72168769
19	PDK2	1.70560246
20	NTRK2	1.50268330
21	SRPK1	1.43956072
22	DYRK2	1.41924030
23	NUAK1	1.39816344
24	VRK1	1.34682434
25	AURKA	1.33540469
26	EPHB2	1.32711781
27	NME1	1.31434383
28	EIF2AK1	1.30969791
29	TESK2	1.27986760
30	TLK1	1.26752589
31	JAK3	1.19146759
32	FGR	1.19097852
33	ABL2	1.19060079
34	TNIK	1.17295508
35	TESK1	1.17226607
36	LIMK1	1.14207399
37	BCKDK	1.11858004
38	CDK19	1.09462075
39	PRKG2	1.08282276
40	OXSR1	1.04965014
41	PIM2	1.04742970
42	PLK1	1.00590883
43	NEK2	0.98429540
44	MAP2K7	0.96610445
45	PLK4	0.93289165
46	CCNB1	0.88283142
47	TRIM28	0.86472439
48	DAPK1	0.86390859
49	ARAF	0.86069574
50	WNK3	0.85378170
51	TSSK6	0.83598526
52	CAMK2G	0.82723631
53	DAPK3	0.80711916
54	MAP3K12	0.74280567
55	PLK3	0.72927505
56	SGK494	0.72876853
57	SGK223	0.72876853
58	MST1R	0.72779033
59	TAF1	0.72487879
60	ADRBK1	0.72083755
61	PIM1	0.71510541
62	PHKG2	0.70576740
63	PHKG1	0.70576740
64	EIF2AK3	0.68529609
65	CSNK1A1	0.68423869
66	CSNK1G3	0.65732749
67	CSNK1G1	0.65406568
68	MAP2K1	0.64933901
69	TTK	0.64878978
70	MARK3	0.64843780
71	AKT2	0.64124849
72	AURKB	0.63543292
73	PTK6	0.61558986
74	ERBB4	0.58480574
75	STK10	0.57948553
76	CAMK2D	0.57841302
77	CAMK1	0.57598244
78	STK39	0.56545170
79	KDR	0.55851830
80	PAK1	0.53991878
81	GRK1	0.53989090
82	RPS6KA5	0.53376452
83	CSNK1G2	0.51888570
84	MYLK	0.51542054
85	CHEK2	0.50679224
86	CAMK2B	0.48023446
87	CDK7	0.46245296
88	BMPR1B	0.45760012
89	CSNK2A1	0.44920192
90	EGFR	0.44454096
91	PRKCD	0.43342835
92	MAP3K11	0.41829674
93	STK38L	0.41219598
94	PRKCE	0.40788687
95	CSNK1A1L	0.37705668
96	BRSK1	0.33007095
97	KSR1	0.32021270
98	SMG1	0.31849247
99	CSNK2A2	0.31356845
100	ILK	0.29541123

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.00980249
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.95072789
3	One carbon pool by folate_Homo sapiens_hsa00670	2.89538678
4	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.89383538
5	Sulfur relay system_Homo sapiens_hsa04122	2.64321578
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.63981406
7	Ribosome_Homo sapiens_hsa03010	2.49718171
8	Sulfur metabolism_Homo sapiens_hsa00920	2.40280207
9	Arginine biosynthesis_Homo sapiens_hsa00220	2.17513889
10	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.16168007
11	Parkinsons disease_Homo sapiens_hsa05012	2.10463476
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.02801463
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.96439030
14	DNA replication_Homo sapiens_hsa03030	1.90324453
15	Galactose metabolism_Homo sapiens_hsa00052	1.88287229
16	Folate biosynthesis_Homo sapiens_hsa00790	1.80586042
17	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.77258480
18	RNA polymerase_Homo sapiens_hsa03020	1.72373342
19	Homologous recombination_Homo sapiens_hsa03440	1.68913687
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.64259585
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.63057142
22	Huntingtons disease_Homo sapiens_hsa05016	1.60508886
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.59820480
24	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.59200566
25	Vibrio cholerae infection_Homo sapiens_hsa05110	1.56475270
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.53092514
27	Base excision repair_Homo sapiens_hsa03410	1.50368119
28	Fatty acid elongation_Homo sapiens_hsa00062	1.47569875
29	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.42193834
30	Fat digestion and absorption_Homo sapiens_hsa04975	1.32669693
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.30698193
32	Glutathione metabolism_Homo sapiens_hsa00480	1.30644791
33	Mismatch repair_Homo sapiens_hsa03430	1.30496064
34	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.30422523
35	Alzheimers disease_Homo sapiens_hsa05010	1.29793850
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27376185
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.26117845
38	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.24279772
39	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.17050094
40	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.16848550
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.15583026
42	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.13231989
43	Spliceosome_Homo sapiens_hsa03040	1.10512475
44	RNA transport_Homo sapiens_hsa03013	1.06442672
45	Carbon metabolism_Homo sapiens_hsa01200	1.04066543
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.95393561
47	Steroid biosynthesis_Homo sapiens_hsa00100	0.94851986
48	Metabolic pathways_Homo sapiens_hsa01100	0.94690255
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.93651211
50	RNA degradation_Homo sapiens_hsa03018	0.92645157
51	Pyruvate metabolism_Homo sapiens_hsa00620	0.89601988
52	Basal transcription factors_Homo sapiens_hsa03022	0.87477634
53	Arginine and proline metabolism_Homo sapiens_hsa00330	0.86483419
54	Purine metabolism_Homo sapiens_hsa00230	0.86340016
55	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.82749751
56	Peroxisome_Homo sapiens_hsa04146	0.81199926
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80596337
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79447856
59	Morphine addiction_Homo sapiens_hsa05032	0.75439607
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74183666
61	Propanoate metabolism_Homo sapiens_hsa00640	0.72013188
62	Pancreatic secretion_Homo sapiens_hsa04972	0.71662492
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71511886
64	Other glycan degradation_Homo sapiens_hsa00511	0.71012138
65	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69715857
66	Cardiac muscle contraction_Homo sapiens_hsa04260	0.67249465
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.66780510
68	Retinol metabolism_Homo sapiens_hsa00830	0.66383765
69	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.65252725
70	GABAergic synapse_Homo sapiens_hsa04727	0.64828925
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.63918031
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63657258
73	Nicotine addiction_Homo sapiens_hsa05033	0.61237905
74	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.61112414
75	Protein export_Homo sapiens_hsa03060	0.60752611
76	Pentose phosphate pathway_Homo sapiens_hsa00030	0.58871898
77	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.58160027
78	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.56061856
79	mRNA surveillance pathway_Homo sapiens_hsa03015	0.55782480
80	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53875292
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50008238
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49475339
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47659197
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.46693187
85	Linoleic acid metabolism_Homo sapiens_hsa00591	0.46666340
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46298543
87	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.45385124
88	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.44169308
89	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.43892742
90	Phenylalanine metabolism_Homo sapiens_hsa00360	0.43653582
91	Phototransduction_Homo sapiens_hsa04744	0.43567705
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43263257
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.42051104
94	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.39983823
95	Nitrogen metabolism_Homo sapiens_hsa00910	0.39456448
96	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.39337726
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.37957528
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36763911
99	Tryptophan metabolism_Homo sapiens_hsa00380	0.35487872
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.34111871

KRT18P38

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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