

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | polyamine biosynthetic process (GO:0006596) | 5.84342473 |
| 2 | gonadal mesoderm development (GO:0007506) | 5.40980498 |
| 3 | hepatocyte apoptotic process (GO:0097284) | 5.31092669 |
| 4 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 5.18667211 |
| 5 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 5.18667211 |
| 6 | ubiquinone biosynthetic process (GO:0006744) | 5.07111616 |
| 7 | proteasome assembly (GO:0043248) | 5.00028906 |
| 8 | regulation of mitochondrial translation (GO:0070129) | 4.72656870 |
| 9 | regulation of cellular respiration (GO:0043457) | 4.71863154 |
| 10 | outer ear morphogenesis (GO:0042473) | 4.61399438 |
| 11 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.59748196 |
| 12 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.59748196 |
| 13 | ubiquinone metabolic process (GO:0006743) | 4.48755296 |
| 14 | quinone biosynthetic process (GO:1901663) | 4.39231445 |
| 15 | positive regulation of cellular amine metabolic process (GO:0033240) | 4.32958770 |
| 16 | icosanoid secretion (GO:0032309) | 4.27464968 |
| 17 | arachidonic acid secretion (GO:0050482) | 4.27464968 |
| 18 | low-density lipoprotein particle clearance (GO:0034383) | 4.26731441 |
| 19 | facial nerve structural organization (GO:0021612) | 4.13614941 |
| 20 | artery development (GO:0060840) | 4.07581094 |
| 21 | polyamine metabolic process (GO:0006595) | 4.05378543 |
| 22 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.01852637 |
| 23 | synaptic transmission, dopaminergic (GO:0001963) | 3.99736202 |
| 24 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.95943945 |
| 25 | negative regulation of sodium ion transport (GO:0010766) | 3.92071204 |
| 26 | ribosomal small subunit assembly (GO:0000028) | 3.83255411 |
| 27 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.78831056 |
| 28 | base-excision repair, AP site formation (GO:0006285) | 3.78473429 |
| 29 | G-protein coupled receptor internalization (GO:0002031) | 3.71746736 |
| 30 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.71184428 |
| 31 | ATP synthesis coupled proton transport (GO:0015986) | 3.71184428 |
| 32 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 3.70186677 |
| 33 | mitochondrion morphogenesis (GO:0070584) | 3.69180017 |
| 34 | regulation of proton transport (GO:0010155) | 3.66145789 |
| 35 | behavioral response to cocaine (GO:0048148) | 3.57515234 |
| 36 | cellular biogenic amine biosynthetic process (GO:0042401) | 3.57143487 |
| 37 | musculoskeletal movement (GO:0050881) | 3.55054537 |
| 38 | multicellular organismal movement (GO:0050879) | 3.55054537 |
| 39 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.51920138 |
| 40 | DNA deamination (GO:0045006) | 3.51506320 |
| 41 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.49726739 |
| 42 | maturation of SSU-rRNA (GO:0030490) | 3.48453195 |
| 43 | protein heterotetramerization (GO:0051290) | 3.45989674 |
| 44 | amine biosynthetic process (GO:0009309) | 3.41062790 |
| 45 | fatty acid derivative transport (GO:1901571) | 3.40679864 |
| 46 | icosanoid transport (GO:0071715) | 3.40679864 |
| 47 | natural killer cell mediated immunity (GO:0002228) | 3.34087574 |
| 48 | natural killer cell mediated cytotoxicity (GO:0042267) | 3.34087574 |
| 49 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.33952264 |
| 50 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.26799455 |
| 51 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.26799455 |
| 52 | chaperone-mediated protein transport (GO:0072321) | 3.26767997 |
| 53 | prepulse inhibition (GO:0060134) | 3.26262953 |
| 54 | regulation of cellular amine metabolic process (GO:0033238) | 3.24289358 |
| 55 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.21370595 |
| 56 | nucleobase biosynthetic process (GO:0046112) | 3.19604604 |
| 57 | plasma lipoprotein particle clearance (GO:0034381) | 3.15825749 |
| 58 | respiratory electron transport chain (GO:0022904) | 3.11807500 |
| 59 | cellular biogenic amine catabolic process (GO:0042402) | 3.10285319 |
| 60 | amine catabolic process (GO:0009310) | 3.10285319 |
| 61 | response to histamine (GO:0034776) | 3.09171568 |
| 62 | electron transport chain (GO:0022900) | 3.06046830 |
| 63 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.05571962 |
| 64 | cardiovascular system development (GO:0072358) | 3.05472269 |
| 65 | mitochondrial RNA metabolic process (GO:0000959) | 3.05057432 |
| 66 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.01747309 |
| 67 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.01572591 |
| 68 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.01143939 |
| 69 | negative regulation of ligase activity (GO:0051352) | 3.00898310 |
| 70 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.00898310 |
| 71 | snRNA processing (GO:0016180) | 3.00724468 |
| 72 | regulation of neurotransmitter uptake (GO:0051580) | 2.99754066 |
| 73 | cranial nerve structural organization (GO:0021604) | 2.99713656 |
| 74 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.98784320 |
| 75 | metallo-sulfur cluster assembly (GO:0031163) | 2.96886572 |
| 76 | iron-sulfur cluster assembly (GO:0016226) | 2.96886572 |
| 77 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.93197631 |
| 78 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.93053761 |
| 79 | maturation of 5.8S rRNA (GO:0000460) | 2.88552369 |
| 80 | ear development (GO:0043583) | 2.87886507 |
| 81 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.87490189 |
| 82 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.87490189 |
| 83 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.87490189 |
| 84 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.86746987 |
| 85 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.86746987 |
| 86 | DNA strand elongation (GO:0022616) | 2.86314792 |
| 87 | positive regulation of renal sodium excretion (GO:0035815) | 2.85190299 |
| 88 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.84075466 |
| 89 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.83128195 |
| 90 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.83128195 |
| 91 | spliceosomal complex assembly (GO:0000245) | 2.82655391 |
| 92 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.81701184 |
| 93 | respiratory chain complex IV assembly (GO:0008535) | 2.81472385 |
| 94 | pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130) | 2.81076221 |
| 95 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.80370524 |
| 96 | ketone biosynthetic process (GO:0042181) | 2.79659033 |
| 97 | cytochrome complex assembly (GO:0017004) | 2.79652543 |
| 98 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.77557965 |
| 99 | cell morphogenesis involved in neuron differentiation (GO:0048667) | 2.77262963 |
| 100 | protein complex biogenesis (GO:0070271) | 2.77260049 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 5.02768689 |
| 2 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 4.14381092 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.57380038 |
| 4 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.52382090 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.37403999 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.36527230 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.30820277 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.11743513 |
| 9 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.99935402 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.97254176 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.87190433 |
| 12 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.78142692 |
| 13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.73986233 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.71153386 |
| 15 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.69576534 |
| 16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.58156459 |
| 17 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.55933069 |
| 18 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.40280767 |
| 19 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.08811690 |
| 20 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.08020781 |
| 21 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.06978141 |
| 22 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.06666762 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.06599682 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.06030369 |
| 25 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.02947569 |
| 26 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.99422617 |
| 27 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.98351246 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.95626044 |
| 29 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.95483609 |
| 30 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.91743869 |
| 31 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.88338298 |
| 32 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.88236878 |
| 33 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.85305533 |
| 34 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.78745552 |
| 35 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.74180275 |
| 36 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.72496244 |
| 37 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.67140879 |
| 38 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.63636370 |
| 39 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59972500 |
| 40 | GATA1_22025678_ChIP-Seq_K562_Human | 1.55198743 |
| 41 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.54305301 |
| 42 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.52668127 |
| 43 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.48591185 |
| 44 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.46191630 |
| 45 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.45371566 |
| 46 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.41916654 |
| 47 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.41001899 |
| 48 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.40202252 |
| 49 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.38416088 |
| 50 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.36645614 |
| 51 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.33362650 |
| 52 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.25595048 |
| 53 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.24892394 |
| 54 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.23727650 |
| 55 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.22777566 |
| 56 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.22350415 |
| 57 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.20575276 |
| 58 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.16849088 |
| 59 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.15842063 |
| 60 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15569676 |
| 61 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.12638653 |
| 62 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.11285240 |
| 63 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.10241986 |
| 64 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.08778977 |
| 65 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.07912780 |
| 66 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.05397639 |
| 67 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.04669427 |
| 68 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.04273947 |
| 69 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.03585284 |
| 70 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.03016962 |
| 71 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.02135952 |
| 72 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.01980222 |
| 73 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.01429412 |
| 74 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.99959567 |
| 75 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.99744617 |
| 76 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.99543871 |
| 77 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.97310875 |
| 78 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.97049220 |
| 79 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.96987848 |
| 80 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.96345911 |
| 81 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.96345911 |
| 82 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.96345911 |
| 83 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.93947085 |
| 84 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93107424 |
| 85 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.92423542 |
| 86 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.91942911 |
| 87 | MYB_26560356_Chip-Seq_TH2_Human | 0.91610831 |
| 88 | P300_27268052_Chip-Seq_Bcells_Human | 0.91093747 |
| 89 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.89444845 |
| 90 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.89288933 |
| 91 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.89128054 |
| 92 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.88870567 |
| 93 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.88599881 |
| 94 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.86930716 |
| 95 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.86871661 |
| 96 | MAF_26560356_Chip-Seq_TH1_Human | 0.86798403 |
| 97 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.86251515 |
| 98 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.86002198 |
| 99 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.85589826 |
| 100 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.85481938 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005451_abnormal_body_composition | 9.97632560 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 3.98264951 |
| 3 | MP0008057_abnormal_DNA_replication | 3.38082956 |
| 4 | MP0003693_abnormal_embryo_hatching | 3.27581896 |
| 5 | MP0000678_abnormal_parathyroid_gland | 2.87212696 |
| 6 | MP0008875_abnormal_xenobiotic_pharmacok | 2.70072817 |
| 7 | MP0003763_abnormal_thymus_physiology | 2.59703076 |
| 8 | MP0008872_abnormal_physiological_respon | 2.48853596 |
| 9 | MP0002796_impaired_skin_barrier | 2.43115437 |
| 10 | MP0008877_abnormal_DNA_methylation | 2.36976291 |
| 11 | MP0008007_abnormal_cellular_replicative | 2.29976770 |
| 12 | MP0004957_abnormal_blastocyst_morpholog | 2.23057773 |
| 13 | MP0003077_abnormal_cell_cycle | 2.16135809 |
| 14 | MP0003315_abnormal_perineum_morphology | 2.13505772 |
| 15 | MP0009379_abnormal_foot_pigmentation | 2.11515974 |
| 16 | MP0003786_premature_aging | 2.02329376 |
| 17 | MP0010094_abnormal_chromosome_stability | 1.99926304 |
| 18 | MP0002877_abnormal_melanocyte_morpholog | 1.99427905 |
| 19 | MP0003111_abnormal_nucleus_morphology | 1.93822929 |
| 20 | MP0005408_hypopigmentation | 1.77163502 |
| 21 | MP0001873_stomach_inflammation | 1.74728549 |
| 22 | MP0008058_abnormal_DNA_repair | 1.73851517 |
| 23 | MP0005671_abnormal_response_to | 1.69736828 |
| 24 | MP0008932_abnormal_embryonic_tissue | 1.66964032 |
| 25 | MP0004147_increased_porphyrin_level | 1.65309463 |
| 26 | MP0003941_abnormal_skin_development | 1.58901392 |
| 27 | MP0009333_abnormal_splenocyte_physiolog | 1.56157563 |
| 28 | MP0003195_calcinosis | 1.55334612 |
| 29 | MP0009046_muscle_twitch | 1.55155986 |
| 30 | MP0005501_abnormal_skin_physiology | 1.48969838 |
| 31 | MP0003252_abnormal_bile_duct | 1.47813030 |
| 32 | MP0005360_urolithiasis | 1.45518286 |
| 33 | MP0003718_maternal_effect | 1.37646700 |
| 34 | MP0008995_early_reproductive_senescence | 1.37078488 |
| 35 | MP0001905_abnormal_dopamine_level | 1.31959235 |
| 36 | MP0005075_abnormal_melanosome_morpholog | 1.28606837 |
| 37 | MP0009840_abnormal_foam_cell | 1.26326896 |
| 38 | MP0005670_abnormal_white_adipose | 1.26153312 |
| 39 | MP0005377_hearing/vestibular/ear_phenot | 1.26115937 |
| 40 | MP0003878_abnormal_ear_physiology | 1.26115937 |
| 41 | MP0005266_abnormal_metabolism | 1.18820151 |
| 42 | MP0000372_irregular_coat_pigmentation | 1.12391635 |
| 43 | MP0005319_abnormal_enzyme/_coenzyme | 1.12141873 |
| 44 | MP0000703_abnormal_thymus_morphology | 1.05605967 |
| 45 | MP0006036_abnormal_mitochondrial_physio | 1.04776013 |
| 46 | MP0000516_abnormal_urinary_system | 1.03261578 |
| 47 | MP0005367_renal/urinary_system_phenotyp | 1.03261578 |
| 48 | MP0002693_abnormal_pancreas_physiology | 1.02964840 |
| 49 | MP0002019_abnormal_tumor_incidence | 1.02718984 |
| 50 | MP0002098_abnormal_vibrissa_morphology | 1.00234088 |
| 51 | MP0003866_abnormal_defecation | 0.99832941 |
| 52 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.99795328 |
| 53 | MP0000647_abnormal_sebaceous_gland | 0.99211640 |
| 54 | MP0002396_abnormal_hematopoietic_system | 0.98667346 |
| 55 | MP0001756_abnormal_urination | 0.98058432 |
| 56 | MP0001853_heart_inflammation | 0.97441601 |
| 57 | MP0003638_abnormal_response/metabolism_ | 0.97404101 |
| 58 | MP0005410_abnormal_fertilization | 0.97385026 |
| 59 | MP0000350_abnormal_cell_proliferation | 0.90092751 |
| 60 | MP0001727_abnormal_embryo_implantation | 0.87995297 |
| 61 | MP0004019_abnormal_vitamin_homeostasis | 0.84789497 |
| 62 | MP0000858_altered_metastatic_potential | 0.83324039 |
| 63 | MP0005220_abnormal_exocrine_pancreas | 0.81739516 |
| 64 | MP0005083_abnormal_biliary_tract | 0.81390946 |
| 65 | MP0001666_abnormal_nutrient_absorption | 0.81054646 |
| 66 | MP0002111_abnormal_tail_morphology | 0.80922396 |
| 67 | MP0003221_abnormal_cardiomyocyte_apopto | 0.80872853 |
| 68 | MP0003950_abnormal_plasma_membrane | 0.80718017 |
| 69 | MP0001800_abnormal_humoral_immune | 0.80484728 |
| 70 | MP0005365_abnormal_bile_salt | 0.79471856 |
| 71 | MP0002722_abnormal_immune_system | 0.79376596 |
| 72 | MP0004381_abnormal_hair_follicle | 0.76863587 |
| 73 | MP0005332_abnormal_amino_acid | 0.76547086 |
| 74 | MP0002177_abnormal_outer_ear | 0.75895500 |
| 75 | MP0001730_embryonic_growth_arrest | 0.71815959 |
| 76 | MP0001216_abnormal_epidermal_layer | 0.70671004 |
| 77 | MP0003191_abnormal_cellular_cholesterol | 0.69150428 |
| 78 | MP0001764_abnormal_homeostasis | 0.68752253 |
| 79 | MP0000490_abnormal_crypts_of | 0.68477345 |
| 80 | MP0000358_abnormal_cell_content/ | 0.68269078 |
| 81 | MP0002210_abnormal_sex_determination | 0.64188813 |
| 82 | MP0003938_abnormal_ear_development | 0.63921043 |
| 83 | MP0009764_decreased_sensitivity_to | 0.63801220 |
| 84 | MP0002277_abnormal_respiratory_mucosa | 0.62816646 |
| 85 | MP0000689_abnormal_spleen_morphology | 0.62254561 |
| 86 | MP0009765_abnormal_xenobiotic_induced | 0.60795158 |
| 87 | MP0000566_synostosis | 0.60044348 |
| 88 | MP0008873_increased_physiological_sensi | 0.58629214 |
| 89 | MP0009643_abnormal_urine_homeostasis | 0.57615626 |
| 90 | MP0003936_abnormal_reproductive_system | 0.57401920 |
| 91 | MP0003567_abnormal_fetal_cardiomyocyte | 0.56925097 |
| 92 | MP0001697_abnormal_embryo_size | 0.56279127 |
| 93 | MP0001929_abnormal_gametogenesis | 0.55701397 |
| 94 | MP0004264_abnormal_extraembryonic_tissu | 0.55042405 |
| 95 | MP0003119_abnormal_digestive_system | 0.54528306 |
| 96 | MP0002420_abnormal_adaptive_immunity | 0.53395394 |
| 97 | MP0001819_abnormal_immune_cell | 0.53185567 |
| 98 | MP0009642_abnormal_blood_homeostasis | 0.52837792 |
| 99 | MP0000716_abnormal_immune_system | 0.52569058 |
| 100 | MP0002429_abnormal_blood_cell | 0.50825199 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | 11 pairs of ribs (HP:0000878) | 8.17878313 |
| 2 | Short nail (HP:0001799) | 6.52504961 |
| 3 | Broad distal phalanx of finger (HP:0009836) | 6.40397499 |
| 4 | Spinal cord compression (HP:0002176) | 4.86628905 |
| 5 | Flared iliac wings (HP:0002869) | 4.71444098 |
| 6 | Birth length less than 3rd percentile (HP:0003561) | 4.60737231 |
| 7 | Radial bowing (HP:0002986) | 4.44237390 |
| 8 | Missing ribs (HP:0000921) | 3.85753757 |
| 9 | Cupped ribs (HP:0000887) | 3.75808625 |
| 10 | Large for gestational age (HP:0001520) | 3.60804916 |
| 11 | Ovoid vertebral bodies (HP:0003300) | 3.60793485 |
| 12 | Acute necrotizing encephalopathy (HP:0006965) | 3.58480435 |
| 13 | Increased CSF lactate (HP:0002490) | 3.45458823 |
| 14 | Irregular vertebral endplates (HP:0003301) | 3.42684265 |
| 15 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.38886903 |
| 16 | Congenital, generalized hypertrichosis (HP:0004540) | 3.38538298 |
| 17 | Acute encephalopathy (HP:0006846) | 3.36009625 |
| 18 | Mitochondrial inheritance (HP:0001427) | 3.35227917 |
| 19 | Bicuspid aortic valve (HP:0001647) | 3.30687889 |
| 20 | Abnormality of alanine metabolism (HP:0010916) | 3.25404520 |
| 21 | Hyperalaninemia (HP:0003348) | 3.25404520 |
| 22 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.25404520 |
| 23 | Fragile skin (HP:0001030) | 3.18430093 |
| 24 | Abnormality of carpal bone ossification (HP:0006257) | 3.17003916 |
| 25 | Short femoral neck (HP:0100864) | 2.92095513 |
| 26 | Slender long bone (HP:0003100) | 2.85063999 |
| 27 | Micronodular cirrhosis (HP:0001413) | 2.83082460 |
| 28 | Coxa valga (HP:0002673) | 2.81092901 |
| 29 | Microretrognathia (HP:0000308) | 2.79401681 |
| 30 | Progressive macrocephaly (HP:0004481) | 2.77467987 |
| 31 | Bowing of the arm (HP:0006488) | 2.76024117 |
| 32 | Bowed forearm bones (HP:0003956) | 2.76024117 |
| 33 | Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108) | 2.74971672 |
| 34 | Hepatocellular necrosis (HP:0001404) | 2.70518700 |
| 35 | Hepatic necrosis (HP:0002605) | 2.62578384 |
| 36 | Sparse scalp hair (HP:0002209) | 2.50047750 |
| 37 | Increased serum lactate (HP:0002151) | 2.49594891 |
| 38 | Delayed gross motor development (HP:0002194) | 2.49350363 |
| 39 | Abnormality of the vertebral endplates (HP:0005106) | 2.47854638 |
| 40 | Mitral regurgitation (HP:0001653) | 2.46206588 |
| 41 | Cerebral hypomyelination (HP:0006808) | 2.42504270 |
| 42 | Abnormal vertebral ossification (HP:0100569) | 2.39333091 |
| 43 | J-shaped sella turcica (HP:0002680) | 2.38917018 |
| 44 | Vacuolated lymphocytes (HP:0001922) | 2.37315746 |
| 45 | Breast hypoplasia (HP:0003187) | 2.37138493 |
| 46 | Vascular calcification (HP:0004934) | 2.35327101 |
| 47 | Oral leukoplakia (HP:0002745) | 2.33488451 |
| 48 | Dislocated radial head (HP:0003083) | 2.32295230 |
| 49 | Abnormal ossification of hand bones (HP:0005921) | 2.32275789 |
| 50 | Increased hepatocellular lipid droplets (HP:0006565) | 2.31555863 |
| 51 | Cerebral edema (HP:0002181) | 2.31254765 |
| 52 | Abnormal hand bone ossification (HP:0010660) | 2.27272657 |
| 53 | Severe short stature (HP:0003510) | 2.26610671 |
| 54 | Aplasia/hypoplasia of the femur (HP:0005613) | 2.24409729 |
| 55 | Lactic acidosis (HP:0003128) | 2.23169271 |
| 56 | Aplasia/Hypoplasia involving the pelvis (HP:0009103) | 2.17919217 |
| 57 | CNS demyelination (HP:0007305) | 2.17536279 |
| 58 | Increased intramyocellular lipid droplets (HP:0012240) | 2.17404946 |
| 59 | Abnormality of the radial head (HP:0003995) | 2.16453958 |
| 60 | Progressive microcephaly (HP:0000253) | 2.15619538 |
| 61 | Lipid accumulation in hepatocytes (HP:0006561) | 2.09072412 |
| 62 | Cleft eyelid (HP:0000625) | 2.07871119 |
| 63 | Pathologic fracture (HP:0002756) | 2.05972086 |
| 64 | Increased serum pyruvate (HP:0003542) | 2.05787679 |
| 65 | Hepatocellular carcinoma (HP:0001402) | 2.03092265 |
| 66 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.02625335 |
| 67 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.02625335 |
| 68 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.01536634 |
| 69 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.99345723 |
| 70 | Type I transferrin isoform profile (HP:0003642) | 1.99153717 |
| 71 | Abnormality of T cells (HP:0002843) | 1.96493040 |
| 72 | Abnormality of T cell physiology (HP:0011840) | 1.96009355 |
| 73 | Lethargy (HP:0001254) | 1.95618442 |
| 74 | Leukodystrophy (HP:0002415) | 1.93724548 |
| 75 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.92815180 |
| 76 | Furrowed tongue (HP:0000221) | 1.92086637 |
| 77 | Pustule (HP:0200039) | 1.88652045 |
| 78 | Molar tooth sign on MRI (HP:0002419) | 1.88196951 |
| 79 | Abnormality of midbrain morphology (HP:0002418) | 1.88196951 |
| 80 | Cellular immunodeficiency (HP:0005374) | 1.88022958 |
| 81 | Tinnitus (HP:0000360) | 1.86950766 |
| 82 | Cardiovascular calcification (HP:0011915) | 1.86942134 |
| 83 | Severe muscular hypotonia (HP:0006829) | 1.86580051 |
| 84 | Exostoses (HP:0100777) | 1.86114174 |
| 85 | Sparse eyelashes (HP:0000653) | 1.83936179 |
| 86 | Stomatitis (HP:0010280) | 1.83607008 |
| 87 | Truncus arteriosus (HP:0001660) | 1.82032204 |
| 88 | Increased muscle lipid content (HP:0009058) | 1.80227119 |
| 89 | Global brain atrophy (HP:0002283) | 1.80144956 |
| 90 | Abnormality of glycolysis (HP:0004366) | 1.77925577 |
| 91 | Mesangial abnormality (HP:0001966) | 1.77547519 |
| 92 | Cerebral palsy (HP:0100021) | 1.76297944 |
| 93 | Renal tubular dysfunction (HP:0000124) | 1.75332069 |
| 94 | Ileus (HP:0002595) | 1.74463925 |
| 95 | Renal tubular acidosis (HP:0001947) | 1.71917421 |
| 96 | Renal Fanconi syndrome (HP:0001994) | 1.71528576 |
| 97 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.71313577 |
| 98 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.71313577 |
| 99 | Abnormal protein glycosylation (HP:0012346) | 1.71313577 |
| 100 | Abnormal glycosylation (HP:0012345) | 1.71313577 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.23497568 |
| 2 | PBK | 3.82935304 |
| 3 | TLK1 | 3.47698715 |
| 4 | VRK2 | 3.40227397 |
| 5 | EPHA2 | 3.28254424 |
| 6 | ZAK | 3.03076483 |
| 7 | NEK1 | 3.01234971 |
| 8 | MAP3K12 | 2.75844446 |
| 9 | PDK2 | 2.43062313 |
| 10 | MAP3K2 | 2.28361059 |
| 11 | ACVR1B | 2.23882400 |
| 12 | NME2 | 2.16054726 |
| 13 | BCKDK | 2.14808727 |
| 14 | TXK | 2.12670362 |
| 15 | MUSK | 2.08606959 |
| 16 | KSR2 | 2.02880145 |
| 17 | GRK1 | 1.81770230 |
| 18 | ADRBK2 | 1.76141097 |
| 19 | LIMK1 | 1.73610324 |
| 20 | VRK1 | 1.61787175 |
| 21 | RPS6KB2 | 1.59939726 |
| 22 | RAF1 | 1.57764655 |
| 23 | NTRK3 | 1.49844490 |
| 24 | CSNK1G3 | 1.49689691 |
| 25 | CDK19 | 1.46103285 |
| 26 | MST1R | 1.39537094 |
| 27 | NEK2 | 1.38900247 |
| 28 | CSNK1A1L | 1.32063461 |
| 29 | KDR | 1.27075172 |
| 30 | PAK4 | 1.21761064 |
| 31 | CHEK2 | 1.13040670 |
| 32 | ARAF | 1.12472314 |
| 33 | EIF2AK1 | 1.12391365 |
| 34 | CDC7 | 1.11621368 |
| 35 | AURKA | 1.11220189 |
| 36 | TESK2 | 1.10961191 |
| 37 | AURKB | 1.06008140 |
| 38 | CSNK1G1 | 1.04261912 |
| 39 | KSR1 | 0.99029660 |
| 40 | MYLK | 0.97299102 |
| 41 | MAP4K1 | 0.96027348 |
| 42 | MAP3K8 | 0.95253502 |
| 43 | EIF2AK3 | 0.94839996 |
| 44 | BMPR1B | 0.92052328 |
| 45 | SMG1 | 0.91647479 |
| 46 | CDK8 | 0.87195815 |
| 47 | OXSR1 | 0.87121527 |
| 48 | CDK4 | 0.85938380 |
| 49 | CSNK1G2 | 0.84707852 |
| 50 | RPS6KA5 | 0.82944725 |
| 51 | ITK | 0.82602487 |
| 52 | TESK1 | 0.80605624 |
| 53 | PLK4 | 0.80557239 |
| 54 | PASK | 0.79535273 |
| 55 | MAP2K1 | 0.78485882 |
| 56 | PIM2 | 0.74642824 |
| 57 | ABL2 | 0.73665505 |
| 58 | CDK9 | 0.73323877 |
| 59 | WNK4 | 0.72520227 |
| 60 | PLK1 | 0.70981337 |
| 61 | STK39 | 0.70714369 |
| 62 | STK4 | 0.69643530 |
| 63 | MELK | 0.67762033 |
| 64 | MAP3K1 | 0.66815964 |
| 65 | MAPKAPK3 | 0.63613284 |
| 66 | WNK1 | 0.60707971 |
| 67 | DAPK1 | 0.60706740 |
| 68 | STK10 | 0.60094700 |
| 69 | MET | 0.59971585 |
| 70 | PTK2B | 0.57970572 |
| 71 | NUAK1 | 0.57413662 |
| 72 | BTK | 0.57080882 |
| 73 | PIK3CA | 0.53691632 |
| 74 | TTK | 0.53457314 |
| 75 | ZAP70 | 0.53214809 |
| 76 | STK16 | 0.49991876 |
| 77 | FRK | 0.48240155 |
| 78 | CAMK2G | 0.47503828 |
| 79 | LCK | 0.46974708 |
| 80 | DAPK3 | 0.45590018 |
| 81 | ATR | 0.44588770 |
| 82 | TGFBR1 | 0.42355937 |
| 83 | MST4 | 0.42296648 |
| 84 | ILK | 0.41075984 |
| 85 | BRAF | 0.40265463 |
| 86 | PAK1 | 0.39673271 |
| 87 | CSNK2A1 | 0.37395935 |
| 88 | PRKCQ | 0.36517451 |
| 89 | PRKCI | 0.36497309 |
| 90 | LMTK2 | 0.36471518 |
| 91 | CAMK2D | 0.34539361 |
| 92 | PIM1 | 0.33820498 |
| 93 | CDK6 | 0.33298609 |
| 94 | TRIM28 | 0.32671588 |
| 95 | CHEK1 | 0.32585979 |
| 96 | SRPK1 | 0.32168856 |
| 97 | CDK7 | 0.31148030 |
| 98 | PTK6 | 0.30451803 |
| 99 | BLK | 0.30032902 |
| 100 | EIF2AK2 | 0.28556754 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.43023407 |
| 2 | Selenocompound metabolism_Homo sapiens_hsa00450 | 4.21825638 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.56871010 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.35748604 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 3.17501883 |
| 6 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 3.07422961 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.83059701 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.67556935 |
| 9 | Mismatch repair_Homo sapiens_hsa03430 | 2.39785420 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.10219548 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 2.08515927 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.01401252 |
| 13 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.97141307 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 1.93896506 |
| 15 | RNA polymerase_Homo sapiens_hsa03020 | 1.91227482 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.86523277 |
| 17 | Alzheimers disease_Homo sapiens_hsa05010 | 1.80402897 |
| 18 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.75880730 |
| 19 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.75690713 |
| 20 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.70805449 |
| 21 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.66951342 |
| 22 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.63919066 |
| 23 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.62383495 |
| 24 | Spliceosome_Homo sapiens_hsa03040 | 1.60154289 |
| 25 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.54184342 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.40980832 |
| 27 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.40963822 |
| 28 | Sulfur relay system_Homo sapiens_hsa04122 | 1.39265709 |
| 29 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.34546525 |
| 30 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.30520736 |
| 31 | RNA transport_Homo sapiens_hsa03013 | 1.29776360 |
| 32 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.29476137 |
| 33 | RNA degradation_Homo sapiens_hsa03018 | 1.28895483 |
| 34 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.23227902 |
| 35 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.22276741 |
| 36 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.21602132 |
| 37 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.15099969 |
| 38 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.11484657 |
| 39 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.09882469 |
| 40 | Alcoholism_Homo sapiens_hsa05034 | 1.09218216 |
| 41 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.00766044 |
| 42 | Thyroid cancer_Homo sapiens_hsa05216 | 0.99947855 |
| 43 | Peroxisome_Homo sapiens_hsa04146 | 0.95076324 |
| 44 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.91540865 |
| 45 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.90817454 |
| 46 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.88285367 |
| 47 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.87186777 |
| 48 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.82182269 |
| 49 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.81740436 |
| 50 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.80435660 |
| 51 | Cell cycle_Homo sapiens_hsa04110 | 0.79794257 |
| 52 | Metabolic pathways_Homo sapiens_hsa01100 | 0.78060461 |
| 53 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.76033051 |
| 54 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.75085610 |
| 55 | Purine metabolism_Homo sapiens_hsa00230 | 0.74952964 |
| 56 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.74519879 |
| 57 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.70394920 |
| 58 | Galactose metabolism_Homo sapiens_hsa00052 | 0.69567173 |
| 59 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.67705742 |
| 60 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.67009388 |
| 61 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.64098688 |
| 62 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.58272915 |
| 63 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.58071224 |
| 64 | Protein export_Homo sapiens_hsa03060 | 0.56111173 |
| 65 | Carbon metabolism_Homo sapiens_hsa01200 | 0.54673106 |
| 66 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.51098334 |
| 67 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.48868677 |
| 68 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.48732826 |
| 69 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.47942871 |
| 70 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.46735319 |
| 71 | Basal transcription factors_Homo sapiens_hsa03022 | 0.46447629 |
| 72 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.45922720 |
| 73 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.45701911 |
| 74 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.44226419 |
| 75 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.43896210 |
| 76 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.41204352 |
| 77 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.41016590 |
| 78 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.40933647 |
| 79 | Phototransduction_Homo sapiens_hsa04744 | 0.39774059 |
| 80 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.37218365 |
| 81 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.36912137 |
| 82 | ABC transporters_Homo sapiens_hsa02010 | 0.36276728 |
| 83 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.36028828 |
| 84 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.35151379 |
| 85 | Bladder cancer_Homo sapiens_hsa05219 | 0.33542458 |
| 86 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.33317993 |
| 87 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.30998183 |
| 88 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.27027279 |
| 89 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.26927674 |
| 90 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.25732013 |
| 91 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.25587929 |
| 92 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.25229014 |
| 93 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.24746578 |
| 94 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.22237605 |
| 95 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.20804486 |
| 96 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.19917368 |
| 97 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.19679562 |
| 98 | Histidine metabolism_Homo sapiens_hsa00340 | 0.19098719 |
| 99 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.19001245 |
| 100 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.16469464 |

