KRT18P39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyamine biosynthetic process (GO:0006596)5.84342473
2gonadal mesoderm development (GO:0007506)5.40980498
3hepatocyte apoptotic process (GO:0097284)5.31092669
4regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)5.18667211
5regulation of dopamine uptake involved in synaptic transmission (GO:0051584)5.18667211
6ubiquinone biosynthetic process (GO:0006744)5.07111616
7proteasome assembly (GO:0043248)5.00028906
8regulation of mitochondrial translation (GO:0070129)4.72656870
9regulation of cellular respiration (GO:0043457)4.71863154
10outer ear morphogenesis (GO:0042473)4.61399438
11tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.59748196
12RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.59748196
13ubiquinone metabolic process (GO:0006743)4.48755296
14quinone biosynthetic process (GO:1901663)4.39231445
15positive regulation of cellular amine metabolic process (GO:0033240)4.32958770
16icosanoid secretion (GO:0032309)4.27464968
17arachidonic acid secretion (GO:0050482)4.27464968
18low-density lipoprotein particle clearance (GO:0034383)4.26731441
19facial nerve structural organization (GO:0021612)4.13614941
20artery development (GO:0060840)4.07581094
21polyamine metabolic process (GO:0006595)4.05378543
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.01852637
23synaptic transmission, dopaminergic (GO:0001963)3.99736202
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.95943945
25negative regulation of sodium ion transport (GO:0010766)3.92071204
26ribosomal small subunit assembly (GO:0000028)3.83255411
27adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.78831056
28base-excision repair, AP site formation (GO:0006285)3.78473429
29G-protein coupled receptor internalization (GO:0002031)3.71746736
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.71184428
31ATP synthesis coupled proton transport (GO:0015986)3.71184428
32regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.70186677
33mitochondrion morphogenesis (GO:0070584)3.69180017
34regulation of proton transport (GO:0010155)3.66145789
35behavioral response to cocaine (GO:0048148)3.57515234
36cellular biogenic amine biosynthetic process (GO:0042401)3.57143487
37musculoskeletal movement (GO:0050881)3.55054537
38multicellular organismal movement (GO:0050879)3.55054537
39regulation of cellular amino acid metabolic process (GO:0006521)3.51920138
40DNA deamination (GO:0045006)3.51506320
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.49726739
42maturation of SSU-rRNA (GO:0030490)3.48453195
43protein heterotetramerization (GO:0051290)3.45989674
44amine biosynthetic process (GO:0009309)3.41062790
45fatty acid derivative transport (GO:1901571)3.40679864
46icosanoid transport (GO:0071715)3.40679864
47natural killer cell mediated immunity (GO:0002228)3.34087574
48natural killer cell mediated cytotoxicity (GO:0042267)3.34087574
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33952264
50positive regulation of lipoprotein lipase activity (GO:0051006)3.26799455
51positive regulation of triglyceride lipase activity (GO:0061365)3.26799455
52chaperone-mediated protein transport (GO:0072321)3.26767997
53prepulse inhibition (GO:0060134)3.26262953
54regulation of cellular amine metabolic process (GO:0033238)3.24289358
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21370595
56nucleobase biosynthetic process (GO:0046112)3.19604604
57plasma lipoprotein particle clearance (GO:0034381)3.15825749
58respiratory electron transport chain (GO:0022904)3.11807500
59cellular biogenic amine catabolic process (GO:0042402)3.10285319
60amine catabolic process (GO:0009310)3.10285319
61response to histamine (GO:0034776)3.09171568
62electron transport chain (GO:0022900)3.06046830
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05571962
64cardiovascular system development (GO:0072358)3.05472269
65mitochondrial RNA metabolic process (GO:0000959)3.05057432
66pyrimidine nucleotide catabolic process (GO:0006244)3.01747309
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01572591
68DNA strand elongation involved in DNA replication (GO:0006271)3.01143939
69negative regulation of ligase activity (GO:0051352)3.00898310
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00898310
71snRNA processing (GO:0016180)3.00724468
72regulation of neurotransmitter uptake (GO:0051580)2.99754066
73cranial nerve structural organization (GO:0021604)2.99713656
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98784320
75metallo-sulfur cluster assembly (GO:0031163)2.96886572
76iron-sulfur cluster assembly (GO:0016226)2.96886572
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93197631
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93053761
79maturation of 5.8S rRNA (GO:0000460)2.88552369
80ear development (GO:0043583)2.87886507
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87490189
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87490189
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87490189
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86746987
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86746987
86DNA strand elongation (GO:0022616)2.86314792
87positive regulation of renal sodium excretion (GO:0035815)2.85190299
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84075466
89signal transduction involved in DNA damage checkpoint (GO:0072422)2.83128195
90signal transduction involved in DNA integrity checkpoint (GO:0072401)2.83128195
91spliceosomal complex assembly (GO:0000245)2.82655391
92RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.81701184
93respiratory chain complex IV assembly (GO:0008535)2.81472385
94pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.81076221
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.80370524
96ketone biosynthetic process (GO:0042181)2.79659033
97cytochrome complex assembly (GO:0017004)2.79652543
98telomere maintenance via semi-conservative replication (GO:0032201)2.77557965
99cell morphogenesis involved in neuron differentiation (GO:0048667)2.77262963
100protein complex biogenesis (GO:0070271)2.77260049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.02768689
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.14381092
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.57380038
4E2F7_22180533_ChIP-Seq_HELA_Human3.52382090
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37403999
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36527230
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.30820277
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.11743513
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99935402
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.97254176
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87190433
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78142692
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73986233
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71153386
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69576534
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58156459
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55933069
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.40280767
19VDR_23849224_ChIP-Seq_CD4+_Human2.08811690
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08020781
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06978141
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06666762
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.06599682
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06030369
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02947569
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99422617
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98351246
28FOXP3_21729870_ChIP-Seq_TREG_Human1.95626044
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95483609
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91743869
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88338298
32DCP1A_22483619_ChIP-Seq_HELA_Human1.88236878
33GABP_19822575_ChIP-Seq_HepG2_Human1.85305533
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78745552
35ELK1_19687146_ChIP-ChIP_HELA_Human1.74180275
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72496244
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67140879
38XRN2_22483619_ChIP-Seq_HELA_Human1.63636370
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59972500
40GATA1_22025678_ChIP-Seq_K562_Human1.55198743
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54305301
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52668127
43TTF2_22483619_ChIP-Seq_HELA_Human1.48591185
44PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46191630
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45371566
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41916654
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41001899
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.40202252
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38416088
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36645614
51KDM5A_27292631_Chip-Seq_BREAST_Human1.33362650
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25595048
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.24892394
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23727650
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22777566
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22350415
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.20575276
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.16849088
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15842063
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15569676
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12638653
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11285240
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10241986
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08778977
65MYC_18940864_ChIP-ChIP_HL60_Human1.07912780
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05397639
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04669427
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04273947
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03585284
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03016962
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02135952
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01980222
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01429412
74MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99959567
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99744617
76NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99543871
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97310875
78PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97049220
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96987848
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96345911
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96345911
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96345911
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93947085
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93107424
85BCOR_27268052_Chip-Seq_Bcells_Human0.92423542
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91942911
87MYB_26560356_Chip-Seq_TH2_Human0.91610831
88P300_27268052_Chip-Seq_Bcells_Human0.91093747
89CIITA_25753668_ChIP-Seq_RAJI_Human0.89444845
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89288933
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89128054
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.88870567
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88599881
94GATA6_25053715_ChIP-Seq_YYC3_Human0.86930716
95ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86871661
96MAF_26560356_Chip-Seq_TH1_Human0.86798403
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86251515
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86002198
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85589826
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85481938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition9.97632560
2MP0003806_abnormal_nucleotide_metabolis3.98264951
3MP0008057_abnormal_DNA_replication3.38082956
4MP0003693_abnormal_embryo_hatching3.27581896
5MP0000678_abnormal_parathyroid_gland2.87212696
6MP0008875_abnormal_xenobiotic_pharmacok2.70072817
7MP0003763_abnormal_thymus_physiology2.59703076
8MP0008872_abnormal_physiological_respon2.48853596
9MP0002796_impaired_skin_barrier2.43115437
10MP0008877_abnormal_DNA_methylation2.36976291
11MP0008007_abnormal_cellular_replicative2.29976770
12MP0004957_abnormal_blastocyst_morpholog2.23057773
13MP0003077_abnormal_cell_cycle2.16135809
14MP0003315_abnormal_perineum_morphology2.13505772
15MP0009379_abnormal_foot_pigmentation2.11515974
16MP0003786_premature_aging2.02329376
17MP0010094_abnormal_chromosome_stability1.99926304
18MP0002877_abnormal_melanocyte_morpholog1.99427905
19MP0003111_abnormal_nucleus_morphology1.93822929
20MP0005408_hypopigmentation1.77163502
21MP0001873_stomach_inflammation1.74728549
22MP0008058_abnormal_DNA_repair1.73851517
23MP0005671_abnormal_response_to1.69736828
24MP0008932_abnormal_embryonic_tissue1.66964032
25MP0004147_increased_porphyrin_level1.65309463
26MP0003941_abnormal_skin_development1.58901392
27MP0009333_abnormal_splenocyte_physiolog1.56157563
28MP0003195_calcinosis1.55334612
29MP0009046_muscle_twitch1.55155986
30MP0005501_abnormal_skin_physiology1.48969838
31MP0003252_abnormal_bile_duct1.47813030
32MP0005360_urolithiasis1.45518286
33MP0003718_maternal_effect1.37646700
34MP0008995_early_reproductive_senescence1.37078488
35MP0001905_abnormal_dopamine_level1.31959235
36MP0005075_abnormal_melanosome_morpholog1.28606837
37MP0009840_abnormal_foam_cell1.26326896
38MP0005670_abnormal_white_adipose1.26153312
39MP0005377_hearing/vestibular/ear_phenot1.26115937
40MP0003878_abnormal_ear_physiology1.26115937
41MP0005266_abnormal_metabolism1.18820151
42MP0000372_irregular_coat_pigmentation1.12391635
43MP0005319_abnormal_enzyme/_coenzyme1.12141873
44MP0000703_abnormal_thymus_morphology1.05605967
45MP0006036_abnormal_mitochondrial_physio1.04776013
46MP0000516_abnormal_urinary_system1.03261578
47MP0005367_renal/urinary_system_phenotyp1.03261578
48MP0002693_abnormal_pancreas_physiology1.02964840
49MP0002019_abnormal_tumor_incidence1.02718984
50MP0002098_abnormal_vibrissa_morphology1.00234088
51MP0003866_abnormal_defecation0.99832941
52MP0005584_abnormal_enzyme/coenzyme_acti0.99795328
53MP0000647_abnormal_sebaceous_gland0.99211640
54MP0002396_abnormal_hematopoietic_system0.98667346
55MP0001756_abnormal_urination0.98058432
56MP0001853_heart_inflammation0.97441601
57MP0003638_abnormal_response/metabolism_0.97404101
58MP0005410_abnormal_fertilization0.97385026
59MP0000350_abnormal_cell_proliferation0.90092751
60MP0001727_abnormal_embryo_implantation0.87995297
61MP0004019_abnormal_vitamin_homeostasis0.84789497
62MP0000858_altered_metastatic_potential0.83324039
63MP0005220_abnormal_exocrine_pancreas0.81739516
64MP0005083_abnormal_biliary_tract0.81390946
65MP0001666_abnormal_nutrient_absorption0.81054646
66MP0002111_abnormal_tail_morphology0.80922396
67MP0003221_abnormal_cardiomyocyte_apopto0.80872853
68MP0003950_abnormal_plasma_membrane0.80718017
69MP0001800_abnormal_humoral_immune0.80484728
70MP0005365_abnormal_bile_salt0.79471856
71MP0002722_abnormal_immune_system0.79376596
72MP0004381_abnormal_hair_follicle0.76863587
73MP0005332_abnormal_amino_acid0.76547086
74MP0002177_abnormal_outer_ear0.75895500
75MP0001730_embryonic_growth_arrest0.71815959
76MP0001216_abnormal_epidermal_layer0.70671004
77MP0003191_abnormal_cellular_cholesterol0.69150428
78MP0001764_abnormal_homeostasis0.68752253
79MP0000490_abnormal_crypts_of0.68477345
80MP0000358_abnormal_cell_content/0.68269078
81MP0002210_abnormal_sex_determination0.64188813
82MP0003938_abnormal_ear_development0.63921043
83MP0009764_decreased_sensitivity_to0.63801220
84MP0002277_abnormal_respiratory_mucosa0.62816646
85MP0000689_abnormal_spleen_morphology0.62254561
86MP0009765_abnormal_xenobiotic_induced0.60795158
87MP0000566_synostosis0.60044348
88MP0008873_increased_physiological_sensi0.58629214
89MP0009643_abnormal_urine_homeostasis0.57615626
90MP0003936_abnormal_reproductive_system0.57401920
91MP0003567_abnormal_fetal_cardiomyocyte0.56925097
92MP0001697_abnormal_embryo_size0.56279127
93MP0001929_abnormal_gametogenesis0.55701397
94MP0004264_abnormal_extraembryonic_tissu0.55042405
95MP0003119_abnormal_digestive_system0.54528306
96MP0002420_abnormal_adaptive_immunity0.53395394
97MP0001819_abnormal_immune_cell0.53185567
98MP0009642_abnormal_blood_homeostasis0.52837792
99MP0000716_abnormal_immune_system0.52569058
100MP0002429_abnormal_blood_cell0.50825199

Predicted human phenotypes

RankGene SetZ-score
111 pairs of ribs (HP:0000878)8.17878313
2Short nail (HP:0001799)6.52504961
3Broad distal phalanx of finger (HP:0009836)6.40397499
4Spinal cord compression (HP:0002176)4.86628905
5Flared iliac wings (HP:0002869)4.71444098
6Birth length less than 3rd percentile (HP:0003561)4.60737231
7Radial bowing (HP:0002986)4.44237390
8Missing ribs (HP:0000921)3.85753757
9Cupped ribs (HP:0000887)3.75808625
10Large for gestational age (HP:0001520)3.60804916
11Ovoid vertebral bodies (HP:0003300)3.60793485
12Acute necrotizing encephalopathy (HP:0006965)3.58480435
13Increased CSF lactate (HP:0002490)3.45458823
14Irregular vertebral endplates (HP:0003301)3.42684265
15Abnormal mitochondria in muscle tissue (HP:0008316)3.38886903
16Congenital, generalized hypertrichosis (HP:0004540)3.38538298
17Acute encephalopathy (HP:0006846)3.36009625
18Mitochondrial inheritance (HP:0001427)3.35227917
19Bicuspid aortic valve (HP:0001647)3.30687889
20Abnormality of alanine metabolism (HP:0010916)3.25404520
21Hyperalaninemia (HP:0003348)3.25404520
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.25404520
23Fragile skin (HP:0001030)3.18430093
24Abnormality of carpal bone ossification (HP:0006257)3.17003916
25Short femoral neck (HP:0100864)2.92095513
26Slender long bone (HP:0003100)2.85063999
27Micronodular cirrhosis (HP:0001413)2.83082460
28Coxa valga (HP:0002673)2.81092901
29Microretrognathia (HP:0000308)2.79401681
30Progressive macrocephaly (HP:0004481)2.77467987
31Bowing of the arm (HP:0006488)2.76024117
32Bowed forearm bones (HP:0003956)2.76024117
33Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.74971672
34Hepatocellular necrosis (HP:0001404)2.70518700
35Hepatic necrosis (HP:0002605)2.62578384
36Sparse scalp hair (HP:0002209)2.50047750
37Increased serum lactate (HP:0002151)2.49594891
38Delayed gross motor development (HP:0002194)2.49350363
39Abnormality of the vertebral endplates (HP:0005106)2.47854638
40Mitral regurgitation (HP:0001653)2.46206588
41Cerebral hypomyelination (HP:0006808)2.42504270
42Abnormal vertebral ossification (HP:0100569)2.39333091
43J-shaped sella turcica (HP:0002680)2.38917018
44Vacuolated lymphocytes (HP:0001922)2.37315746
45Breast hypoplasia (HP:0003187)2.37138493
46Vascular calcification (HP:0004934)2.35327101
47Oral leukoplakia (HP:0002745)2.33488451
48Dislocated radial head (HP:0003083)2.32295230
49Abnormal ossification of hand bones (HP:0005921)2.32275789
50Increased hepatocellular lipid droplets (HP:0006565)2.31555863
51Cerebral edema (HP:0002181)2.31254765
52Abnormal hand bone ossification (HP:0010660)2.27272657
53Severe short stature (HP:0003510)2.26610671
54Aplasia/hypoplasia of the femur (HP:0005613)2.24409729
55Lactic acidosis (HP:0003128)2.23169271
56Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.17919217
57CNS demyelination (HP:0007305)2.17536279
58Increased intramyocellular lipid droplets (HP:0012240)2.17404946
59Abnormality of the radial head (HP:0003995)2.16453958
60Progressive microcephaly (HP:0000253)2.15619538
61Lipid accumulation in hepatocytes (HP:0006561)2.09072412
62Cleft eyelid (HP:0000625)2.07871119
63Pathologic fracture (HP:0002756)2.05972086
64Increased serum pyruvate (HP:0003542)2.05787679
65Hepatocellular carcinoma (HP:0001402)2.03092265
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02625335
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02625335
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01536634
69Elevated erythrocyte sedimentation rate (HP:0003565)1.99345723
70Type I transferrin isoform profile (HP:0003642)1.99153717
71Abnormality of T cells (HP:0002843)1.96493040
72Abnormality of T cell physiology (HP:0011840)1.96009355
73Lethargy (HP:0001254)1.95618442
74Leukodystrophy (HP:0002415)1.93724548
75Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92815180
76Furrowed tongue (HP:0000221)1.92086637
77Pustule (HP:0200039)1.88652045
78Molar tooth sign on MRI (HP:0002419)1.88196951
79Abnormality of midbrain morphology (HP:0002418)1.88196951
80Cellular immunodeficiency (HP:0005374)1.88022958
81Tinnitus (HP:0000360)1.86950766
82Cardiovascular calcification (HP:0011915)1.86942134
83Severe muscular hypotonia (HP:0006829)1.86580051
84Exostoses (HP:0100777)1.86114174
85Sparse eyelashes (HP:0000653)1.83936179
86Stomatitis (HP:0010280)1.83607008
87Truncus arteriosus (HP:0001660)1.82032204
88Increased muscle lipid content (HP:0009058)1.80227119
89Global brain atrophy (HP:0002283)1.80144956
90Abnormality of glycolysis (HP:0004366)1.77925577
91Mesangial abnormality (HP:0001966)1.77547519
92Cerebral palsy (HP:0100021)1.76297944
93Renal tubular dysfunction (HP:0000124)1.75332069
94Ileus (HP:0002595)1.74463925
95Renal tubular acidosis (HP:0001947)1.71917421
96Renal Fanconi syndrome (HP:0001994)1.71528576
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71313577
98Abnormal protein N-linked glycosylation (HP:0012347)1.71313577
99Abnormal protein glycosylation (HP:0012346)1.71313577
100Abnormal glycosylation (HP:0012345)1.71313577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.23497568
2PBK3.82935304
3TLK13.47698715
4VRK23.40227397
5EPHA23.28254424
6ZAK3.03076483
7NEK13.01234971
8MAP3K122.75844446
9PDK22.43062313
10MAP3K22.28361059
11ACVR1B2.23882400
12NME22.16054726
13BCKDK2.14808727
14TXK2.12670362
15MUSK2.08606959
16KSR22.02880145
17GRK11.81770230
18ADRBK21.76141097
19LIMK11.73610324
20VRK11.61787175
21RPS6KB21.59939726
22RAF11.57764655
23NTRK31.49844490
24CSNK1G31.49689691
25CDK191.46103285
26MST1R1.39537094
27NEK21.38900247
28CSNK1A1L1.32063461
29KDR1.27075172
30PAK41.21761064
31CHEK21.13040670
32ARAF1.12472314
33EIF2AK11.12391365
34CDC71.11621368
35AURKA1.11220189
36TESK21.10961191
37AURKB1.06008140
38CSNK1G11.04261912
39KSR10.99029660
40MYLK0.97299102
41MAP4K10.96027348
42MAP3K80.95253502
43EIF2AK30.94839996
44BMPR1B0.92052328
45SMG10.91647479
46CDK80.87195815
47OXSR10.87121527
48CDK40.85938380
49CSNK1G20.84707852
50RPS6KA50.82944725
51ITK0.82602487
52TESK10.80605624
53PLK40.80557239
54PASK0.79535273
55MAP2K10.78485882
56PIM20.74642824
57ABL20.73665505
58CDK90.73323877
59WNK40.72520227
60PLK10.70981337
61STK390.70714369
62STK40.69643530
63MELK0.67762033
64MAP3K10.66815964
65MAPKAPK30.63613284
66WNK10.60707971
67DAPK10.60706740
68STK100.60094700
69MET0.59971585
70PTK2B0.57970572
71NUAK10.57413662
72BTK0.57080882
73PIK3CA0.53691632
74TTK0.53457314
75ZAP700.53214809
76STK160.49991876
77FRK0.48240155
78CAMK2G0.47503828
79LCK0.46974708
80DAPK30.45590018
81ATR0.44588770
82TGFBR10.42355937
83MST40.42296648
84ILK0.41075984
85BRAF0.40265463
86PAK10.39673271
87CSNK2A10.37395935
88PRKCQ0.36517451
89PRKCI0.36497309
90LMTK20.36471518
91CAMK2D0.34539361
92PIM10.33820498
93CDK60.33298609
94TRIM280.32671588
95CHEK10.32585979
96SRPK10.32168856
97CDK70.31148030
98PTK60.30451803
99BLK0.30032902
100EIF2AK20.28556754

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.43023407
2Selenocompound metabolism_Homo sapiens_hsa004504.21825638
3Ribosome_Homo sapiens_hsa030103.56871010
4Oxidative phosphorylation_Homo sapiens_hsa001903.35748604
5DNA replication_Homo sapiens_hsa030303.17501883
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.07422961
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83059701
8Parkinsons disease_Homo sapiens_hsa050122.67556935
9Mismatch repair_Homo sapiens_hsa034302.39785420
10Homologous recombination_Homo sapiens_hsa034402.10219548
11Base excision repair_Homo sapiens_hsa034102.08515927
12Pyrimidine metabolism_Homo sapiens_hsa002402.01401252
13Sulfur metabolism_Homo sapiens_hsa009201.97141307
14Huntingtons disease_Homo sapiens_hsa050161.93896506
15RNA polymerase_Homo sapiens_hsa030201.91227482
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86523277
17Alzheimers disease_Homo sapiens_hsa050101.80402897
18Nitrogen metabolism_Homo sapiens_hsa009101.75880730
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.75690713
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70805449
21Systemic lupus erythematosus_Homo sapiens_hsa053221.66951342
22Fat digestion and absorption_Homo sapiens_hsa049751.63919066
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62383495
24Spliceosome_Homo sapiens_hsa030401.60154289
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54184342
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40980832
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40963822
28Sulfur relay system_Homo sapiens_hsa041221.39265709
29Folate biosynthesis_Homo sapiens_hsa007901.34546525
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30520736
31RNA transport_Homo sapiens_hsa030131.29776360
32Fatty acid elongation_Homo sapiens_hsa000621.29476137
33RNA degradation_Homo sapiens_hsa030181.28895483
34One carbon pool by folate_Homo sapiens_hsa006701.23227902
35Primary immunodeficiency_Homo sapiens_hsa053401.22276741
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21602132
37Ether lipid metabolism_Homo sapiens_hsa005651.15099969
38Cardiac muscle contraction_Homo sapiens_hsa042601.11484657
39Nucleotide excision repair_Homo sapiens_hsa034201.09882469
40Alcoholism_Homo sapiens_hsa050341.09218216
41N-Glycan biosynthesis_Homo sapiens_hsa005101.00766044
42Thyroid cancer_Homo sapiens_hsa052160.99947855
43Peroxisome_Homo sapiens_hsa041460.95076324
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91540865
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90817454
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88285367
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87186777
48Glycerolipid metabolism_Homo sapiens_hsa005610.82182269
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81740436
50Fanconi anemia pathway_Homo sapiens_hsa034600.80435660
51Cell cycle_Homo sapiens_hsa041100.79794257
52Metabolic pathways_Homo sapiens_hsa011000.78060461
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76033051
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.75085610
55Purine metabolism_Homo sapiens_hsa002300.74952964
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.74519879
57Vibrio cholerae infection_Homo sapiens_hsa051100.70394920
58Galactose metabolism_Homo sapiens_hsa000520.69567173
59Regulation of autophagy_Homo sapiens_hsa041400.67705742
60Glutathione metabolism_Homo sapiens_hsa004800.67009388
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64098688
62Collecting duct acid secretion_Homo sapiens_hsa049660.58272915
63Viral carcinogenesis_Homo sapiens_hsa052030.58071224
64Protein export_Homo sapiens_hsa030600.56111173
65Carbon metabolism_Homo sapiens_hsa012000.54673106
66Arginine biosynthesis_Homo sapiens_hsa002200.51098334
67p53 signaling pathway_Homo sapiens_hsa041150.48868677
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48732826
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47942871
70T cell receptor signaling pathway_Homo sapiens_hsa046600.46735319
71Basal transcription factors_Homo sapiens_hsa030220.46447629
72Phenylalanine metabolism_Homo sapiens_hsa003600.45922720
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.45701911
74Pyruvate metabolism_Homo sapiens_hsa006200.44226419
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43896210
76Arginine and proline metabolism_Homo sapiens_hsa003300.41204352
77Tyrosine metabolism_Homo sapiens_hsa003500.41016590
78Biosynthesis of amino acids_Homo sapiens_hsa012300.40933647
79Phototransduction_Homo sapiens_hsa047440.39774059
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37218365
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36912137
82ABC transporters_Homo sapiens_hsa020100.36276728
83Caffeine metabolism_Homo sapiens_hsa002320.36028828
84Linoleic acid metabolism_Homo sapiens_hsa005910.35151379
85Bladder cancer_Homo sapiens_hsa052190.33542458
86Epstein-Barr virus infection_Homo sapiens_hsa051690.33317993
87Chemical carcinogenesis_Homo sapiens_hsa052040.30998183
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.27027279
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26927674
90Tryptophan metabolism_Homo sapiens_hsa003800.25732013
91Steroid biosynthesis_Homo sapiens_hsa001000.25587929
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.25229014
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24746578
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.22237605
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20804486
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19917368
97Pentose phosphate pathway_Homo sapiens_hsa000300.19679562
98Histidine metabolism_Homo sapiens_hsa003400.19098719
99Arachidonic acid metabolism_Homo sapiens_hsa005900.19001245
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.16469464

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