KRT18P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)9.16730240
2regulation of retinoic acid receptor signaling pathway (GO:0048385)7.58686852
3DNA replication-dependent nucleosome assembly (GO:0006335)5.39439649
4DNA replication-dependent nucleosome organization (GO:0034723)5.39439649
5rRNA methylation (GO:0031167)5.21449326
6DNA replication checkpoint (GO:0000076)5.07868999
7high-density lipoprotein particle remodeling (GO:0034375)5.01433028
8regulation of triglyceride catabolic process (GO:0010896)4.93602019
9peptidyl-glutamic acid carboxylation (GO:0017187)4.85869110
10protein carboxylation (GO:0018214)4.85869110
11very-low-density lipoprotein particle assembly (GO:0034379)4.83620169
12meiotic chromosome segregation (GO:0045132)4.75077319
13G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.69382572
14rRNA modification (GO:0000154)4.66439194
15plasma lipoprotein particle assembly (GO:0034377)4.23467875
16reverse cholesterol transport (GO:0043691)4.13955269
17regulation of nuclear cell cycle DNA replication (GO:0033262)4.12099705
18DNA strand renaturation (GO:0000733)4.10866997
19phospholipid efflux (GO:0033700)4.06252971
20DNA replication initiation (GO:0006270)3.85184185
21mitotic sister chromatid segregation (GO:0000070)3.76045908
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.75787262
23glutamine family amino acid biosynthetic process (GO:0009084)3.67910973
24proteasome assembly (GO:0043248)3.66252440
25DNA strand elongation involved in DNA replication (GO:0006271)3.60638353
26protein-lipid complex assembly (GO:0065005)3.58005090
27ribosome assembly (GO:0042255)3.53420310
28DNA strand elongation (GO:0022616)3.51973460
29transcription from mitochondrial promoter (GO:0006390)3.45391396
30regulation of bile acid biosynthetic process (GO:0070857)3.43537585
31plasma lipoprotein particle clearance (GO:0034381)3.42586193
32termination of RNA polymerase III transcription (GO:0006386)3.42408519
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.42408519
34GDP-mannose metabolic process (GO:0019673)3.41431786
35sperm capacitation (GO:0048240)3.29550100
36dicarboxylic acid biosynthetic process (GO:0043650)3.29160945
37purinergic nucleotide receptor signaling pathway (GO:0035590)3.26229863
38protein-lipid complex remodeling (GO:0034368)3.22651465
39macromolecular complex remodeling (GO:0034367)3.22651465
40plasma lipoprotein particle remodeling (GO:0034369)3.22651465
41spliceosomal snRNP assembly (GO:0000387)3.20042351
42sister chromatid segregation (GO:0000819)3.12020265
43telomere maintenance via semi-conservative replication (GO:0032201)3.10711629
44ribosome biogenesis (GO:0042254)3.06772429
45mitotic metaphase plate congression (GO:0007080)3.06393866
46translesion synthesis (GO:0019985)3.06042061
47DNA double-strand break processing (GO:0000729)3.03404584
48removal of superoxide radicals (GO:0019430)3.00783728
49cellular response to superoxide (GO:0071451)3.00783728
50cellular response to oxygen radical (GO:0071450)3.00783728
51pentose metabolic process (GO:0019321)2.99255856
52regulation of cholesterol esterification (GO:0010872)2.98128721
53spliceosomal tri-snRNP complex assembly (GO:0000244)2.95147335
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93662391
55mRNA cleavage (GO:0006379)2.90274565
56water-soluble vitamin biosynthetic process (GO:0042364)2.87916797
57regulation of triglyceride metabolic process (GO:0090207)2.84851288
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84779671
59pyrimidine-containing compound transmembrane transport (GO:0072531)2.83957526
60ovulation from ovarian follicle (GO:0001542)2.83940173
61protein autoprocessing (GO:0016540)2.82394357
62mitochondrial RNA metabolic process (GO:0000959)2.81941653
63rRNA processing (GO:0006364)2.81509918
64multicellular organism reproduction (GO:0032504)2.80285146
65negative regulation of lipase activity (GO:0060192)2.75364736
66telomere maintenance via recombination (GO:0000722)2.74962467
67plasma lipoprotein particle organization (GO:0071827)2.74363450
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74293411
69transepithelial transport (GO:0070633)2.73795924
70non-recombinational repair (GO:0000726)2.73711722
71double-strand break repair via nonhomologous end joining (GO:0006303)2.73711722
72DNA integration (GO:0015074)2.73136287
73pseudouridine synthesis (GO:0001522)2.70281998
74cholesterol efflux (GO:0033344)2.68787337
75rRNA metabolic process (GO:0016072)2.67765006
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67037617
77DNA catabolic process, exonucleolytic (GO:0000738)2.66318252
78telomere maintenance via telomere lengthening (GO:0010833)2.65643439
79negative regulation of fatty acid biosynthetic process (GO:0045717)2.65608783
80ncRNA 3-end processing (GO:0043628)2.64700481
81somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64647330
82somatic hypermutation of immunoglobulin genes (GO:0016446)2.64647330
83metaphase plate congression (GO:0051310)2.64317687
84glycerophospholipid catabolic process (GO:0046475)2.62814147
85hepatocyte apoptotic process (GO:0097284)2.62524482
86positive regulation of triglyceride lipase activity (GO:0061365)2.62461467
87positive regulation of lipoprotein lipase activity (GO:0051006)2.62461467
88nucleoside transmembrane transport (GO:1901642)2.62393617
89positive regulation of triglyceride metabolic process (GO:0090208)2.62210234
90cellular response to ATP (GO:0071318)2.60924987
91regulation of mitochondrial translation (GO:0070129)2.59770490
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.58409187
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.56647690
94pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.56376171
953-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.54171664
96purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.54171664
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53694046
98transcription from RNA polymerase I promoter (GO:0006360)2.53509616
99CENP-A containing nucleosome assembly (GO:0034080)2.52639023
100mitotic chromosome condensation (GO:0007076)2.50091488

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.51424242
2E2F7_22180533_ChIP-Seq_HELA_Human5.98546734
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.15261605
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10487604
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.00585729
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92585088
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84487041
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.69862309
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69036268
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.67977118
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61995273
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.50207452
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.41749297
14XRN2_22483619_ChIP-Seq_HELA_Human2.34299392
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.33788339
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.27774697
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27489467
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16723528
19DCP1A_22483619_ChIP-Seq_HELA_Human2.15263849
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.13954273
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.02337144
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00974109
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.00595094
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97455252
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.94858788
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.92956232
27GABP_19822575_ChIP-Seq_HepG2_Human1.87434811
28VDR_23849224_ChIP-Seq_CD4+_Human1.83082677
29AR_21909140_ChIP-Seq_LNCAP_Human1.81513576
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81001777
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80198974
32FOXP3_21729870_ChIP-Seq_TREG_Human1.74111538
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73578252
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71984343
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70025347
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69666274
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69515941
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.65996512
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65473959
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.65184434
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57854662
42HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.57152227
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52592711
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50155225
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49232704
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.47931503
47P68_20966046_ChIP-Seq_HELA_Human1.46319361
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38213739
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38141611
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37905127
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36665820
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32858454
53CIITA_25753668_ChIP-Seq_RAJI_Human1.32158533
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27991419
55BCOR_27268052_Chip-Seq_Bcells_Human1.26856000
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24793625
57KDM5A_27292631_Chip-Seq_BREAST_Human1.24435966
58ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23487785
59VDR_21846776_ChIP-Seq_THP-1_Human1.23065149
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22968961
61E2F1_20622854_ChIP-Seq_HELA_Human1.22780774
62TTF2_22483619_ChIP-Seq_HELA_Human1.22142868
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17888209
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17047447
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16981736
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15701356
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14922998
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14581833
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.13053351
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11785407
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.09987703
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07434262
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04086630
74BCL6_27268052_Chip-Seq_Bcells_Human1.03337940
75PHF8_20622854_ChIP-Seq_HELA_Human1.03149078
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.02592543
77RARA_24833708_ChIP-Seq_LIVER_Mouse1.01206134
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00637098
79PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99002093
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98990297
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97356037
82FOXP1_21924763_ChIP-Seq_HESCs_Human0.97216752
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96460471
84SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94678562
85GATA6_25053715_ChIP-Seq_YYC3_Human0.94589873
86CTCF_21964334_Chip-Seq_Bcells_Human0.91252831
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.90342842
88ELK1_19687146_ChIP-ChIP_HELA_Human0.87724465
89RAC3_21632823_ChIP-Seq_H3396_Human0.87626575
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85805888
91RARB_24833708_ChIP-Seq_LIVER_Mouse0.85459509
92RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85154785
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84079417
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83375468
95ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83363261
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82688839
97ATF3_27146783_Chip-Seq_COLON_Human0.82130822
98P300_27268052_Chip-Seq_Bcells_Human0.80664078
99IRF1_19129219_ChIP-ChIP_H3396_Human0.80252259
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79190379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell5.21832301
2MP0003136_yellow_coat_color4.41727318
3MP0005360_urolithiasis4.18660493
4MP0003111_abnormal_nucleus_morphology3.71638866
5MP0003693_abnormal_embryo_hatching3.39467139
6MP0005451_abnormal_body_composition3.39126906
7MP0010094_abnormal_chromosome_stability3.29616436
8MP0008057_abnormal_DNA_replication3.26317806
9MP0008875_abnormal_xenobiotic_pharmacok3.23714732
10MP0004957_abnormal_blastocyst_morpholog2.98034919
11MP0002638_abnormal_pupillary_reflex2.83254409
12MP0005171_absent_coat_pigmentation2.81822372
13MP0002254_reproductive_system_inflammat2.72284633
14MP0005083_abnormal_biliary_tract2.24851541
15MP0005174_abnormal_tail_pigmentation2.23907584
16MP0003077_abnormal_cell_cycle2.21235782
17MP0006054_spinal_hemorrhage2.13560834
18MP0001986_abnormal_taste_sensitivity2.11040996
19MP0003878_abnormal_ear_physiology2.00557013
20MP0005377_hearing/vestibular/ear_phenot2.00557013
21MP0002139_abnormal_hepatobiliary_system1.98134723
22MP0001764_abnormal_homeostasis1.97760364
23MP0005365_abnormal_bile_salt1.93671830
24MP0000751_myopathy1.88955066
25MP0004381_abnormal_hair_follicle1.87857815
26MP0003718_maternal_effect1.82198080
27MP0003806_abnormal_nucleotide_metabolis1.79783615
28MP0003646_muscle_fatigue1.71480731
29MP0005409_darkened_coat_color1.69039566
30MP0008058_abnormal_DNA_repair1.68468036
31MP0004019_abnormal_vitamin_homeostasis1.64832161
32MP0010352_gastrointestinal_tract_polyps1.63883294
33MP0003950_abnormal_plasma_membrane1.62737377
34MP0002796_impaired_skin_barrier1.61589212
35MP0005423_abnormal_somatic_nervous1.55838829
36MP0001919_abnormal_reproductive_system1.53122489
37MP0004043_abnormal_pH_regulation1.44319629
38MP0005085_abnormal_gallbladder_physiolo1.40960297
39MP0002876_abnormal_thyroid_physiology1.39552127
40MP0004233_abnormal_muscle_weight1.35246201
41MP0005167_abnormal_blood-brain_barrier1.32363069
42MP0010329_abnormal_lipoprotein_level1.31962850
43MP0000747_muscle_weakness1.26812688
44MP0008004_abnormal_stomach_pH1.21007917
45MP0005076_abnormal_cell_differentiation1.17289529
46MP0005389_reproductive_system_phenotype1.15863053
47MP0001730_embryonic_growth_arrest1.13335571
48MP0005058_abnormal_lysosome_morphology1.12380066
49MP0002160_abnormal_reproductive_system1.10372051
50MP0000358_abnormal_cell_content/1.09082336
51MP0005501_abnormal_skin_physiology1.07632280
52MP0001756_abnormal_urination1.07170775
53MP0005332_abnormal_amino_acid1.04233909
54MP0002210_abnormal_sex_determination1.01269617
55MP0002269_muscular_atrophy0.99760488
56MP0003941_abnormal_skin_development0.99596097
57MP0001697_abnormal_embryo_size0.96920375
58MP0005410_abnormal_fertilization0.96825131
59MP0000372_irregular_coat_pigmentation0.96724847
60MP0001929_abnormal_gametogenesis0.96290530
61MP0001672_abnormal_embryogenesis/_devel0.95290374
62MP0005380_embryogenesis_phenotype0.95290374
63MP0003195_calcinosis0.95048704
64MP0001188_hyperpigmentation0.94965246
65MP0008932_abnormal_embryonic_tissue0.93156118
66MP0000015_abnormal_ear_pigmentation0.92249092
67MP0001666_abnormal_nutrient_absorption0.91312933
68MP0006035_abnormal_mitochondrial_morpho0.88845954
69MP0000350_abnormal_cell_proliferation0.87696577
70MP0005084_abnormal_gallbladder_morpholo0.86235068
71MP0008872_abnormal_physiological_respon0.85530658
72MP0002080_prenatal_lethality0.83614251
73MP0000538_abnormal_urinary_bladder0.83164082
74MP0003984_embryonic_growth_retardation0.82306335
75MP0002019_abnormal_tumor_incidence0.81520188
76MP0002088_abnormal_embryonic_growth/wei0.80915239
77MP0002086_abnormal_extraembryonic_tissu0.80899998
78MP0001502_abnormal_circadian_rhythm0.79508938
79MP0001119_abnormal_female_reproductive0.78476181
80MP0000490_abnormal_crypts_of0.77983267
81MP0003186_abnormal_redox_activity0.77688574
82MP0009643_abnormal_urine_homeostasis0.76539677
83MP0001968_abnormal_touch/_nociception0.75163100
84MP0003699_abnormal_female_reproductive0.71347305
85MP0010386_abnormal_urinary_bladder0.69249023
86MP0002060_abnormal_skin_morphology0.67694221
87MP0005408_hypopigmentation0.67664149
88MP0001661_extended_life_span0.67548348
89MP0000653_abnormal_sex_gland0.67096853
90MP0003632_abnormal_nervous_system0.66047947
91MP0005376_homeostasis/metabolism_phenot0.63158226
92MP0008007_abnormal_cellular_replicative0.62019982
93MP0009278_abnormal_bone_marrow0.60444636
94MP0001915_intracranial_hemorrhage0.59799103
95MP0005319_abnormal_enzyme/_coenzyme0.59389303
96MP0010234_abnormal_vibrissa_follicle0.58669467
97MP0001145_abnormal_male_reproductive0.57969306
98MP0005330_cardiomyopathy0.57694061
99MP0002161_abnormal_fertility/fecundity0.57408435
100MP0003453_abnormal_keratinocyte_physiol0.57376475

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)6.65649907
2Birth length less than 3rd percentile (HP:0003561)4.63046746
3Malnutrition (HP:0004395)4.29128427
4Hypolipoproteinemia (HP:0010981)4.14778217
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61274188
6Neonatal respiratory distress (HP:0002643)3.58097850
7Prolonged partial thromboplastin time (HP:0003645)3.53194417
8Urethral obstruction (HP:0000796)3.24692611
9Dyschromatopsia (HP:0007641)3.21634467
10Vacuolated lymphocytes (HP:0001922)3.16038611
11Abnormality of pyrimidine metabolism (HP:0004353)3.14604687
12Attenuation of retinal blood vessels (HP:0007843)3.09358535
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.04567054
14Abnormality of alanine metabolism (HP:0010916)3.04567054
15Hyperalaninemia (HP:0003348)3.04567054
16Absent thumb (HP:0009777)3.02648041
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.99940098
18Squamous cell carcinoma (HP:0002860)2.99100805
19Abnormality of the preputium (HP:0100587)2.96041538
20Meckel diverticulum (HP:0002245)2.92912531
21Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.92441785
22Joint hemorrhage (HP:0005261)2.91937859
23Abnormality of the ileum (HP:0001549)2.87820181
24Hypoplasia of the capital femoral epiphysis (HP:0003090)2.81149136
25Chromsome breakage (HP:0040012)2.80653355
26Patellar aplasia (HP:0006443)2.80456397
27Absent radius (HP:0003974)2.79937695
28Testicular atrophy (HP:0000029)2.79544938
29Microvesicular hepatic steatosis (HP:0001414)2.64660472
30Absent forearm bone (HP:0003953)2.63296425
31Aplasia involving forearm bones (HP:0009822)2.63296425
32Popliteal pterygium (HP:0009756)2.61763623
33Bilateral sensorineural hearing impairment (HP:0008619)2.61006136
34Abnormality of cochlea (HP:0000375)2.59976809
35Abnormality of monocarboxylic acid metabolism (HP:0010996)2.57397282
36Lipid accumulation in hepatocytes (HP:0006561)2.57039294
37Fatigable weakness (HP:0003473)2.55696274
38Abnormality of the neuromuscular junction (HP:0003398)2.55696274
39Deep venous thrombosis (HP:0002625)2.53659556
40Vaginal fistula (HP:0004320)2.53389737
41Aplasia/Hypoplasia of the patella (HP:0006498)2.52400104
42Pigmentary retinal degeneration (HP:0001146)2.50282766
43Vascular calcification (HP:0004934)2.50130848
44Confusion (HP:0001289)2.47520082
45Congenital stationary night blindness (HP:0007642)2.45247508
46Respiratory difficulties (HP:0002880)2.41513055
47Facial hemangioma (HP:0000329)2.36194782
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31743609
49Tinnitus (HP:0000360)2.31429670
50Rib fusion (HP:0000902)2.26606460
51Ulnar bowing (HP:0003031)2.26003817
52Short thumb (HP:0009778)2.23454668
53Steatorrhea (HP:0002570)2.22073141
54Rectal fistula (HP:0100590)2.20628425
55Rectovaginal fistula (HP:0000143)2.20628425
56Fat malabsorption (HP:0002630)2.19960822
57Capillary hemangiomas (HP:0005306)2.18032670
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.18018461
59Intrahepatic cholestasis (HP:0001406)2.16578382
60Opisthotonus (HP:0002179)2.15906587
61Hyperglycinemia (HP:0002154)2.15308804
62Impulsivity (HP:0100710)2.14052744
63Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.13386266
64Absent epiphyses (HP:0010577)2.13386266
65Intestinal fistula (HP:0100819)2.12816762
66Abnormality of chromosome stability (HP:0003220)2.09924305
67Hypoplasia of the radius (HP:0002984)2.09360924
68Back pain (HP:0003418)2.08323938
69Bony spicule pigmentary retinopathy (HP:0007737)2.06927204
70Poikiloderma (HP:0001029)2.04640241
71Acanthocytosis (HP:0001927)2.02704889
72Epiphyseal stippling (HP:0010655)2.01357307
73Bicornuate uterus (HP:0000813)2.00848619
74Cardiovascular calcification (HP:0011915)2.00544247
75Pendular nystagmus (HP:0012043)2.00394710
76Abnormality of methionine metabolism (HP:0010901)2.00289359
77Mitral stenosis (HP:0001718)1.95541329
78Hypophosphatemic rickets (HP:0004912)1.95158000
79Hyperlipoproteinemia (HP:0010980)1.94179074
80Increased hepatocellular lipid droplets (HP:0006565)1.93446699
81Reduced antithrombin III activity (HP:0001976)1.92779272
82Amniotic constriction ring (HP:0009775)1.91614218
83Abnormality of placental membranes (HP:0011409)1.91614218
84Choroideremia (HP:0001139)1.90882661
85Abnormality of the common coagulation pathway (HP:0010990)1.90548922
86Parakeratosis (HP:0001036)1.89978447
87Abnormality of the intrinsic pathway (HP:0010989)1.89399693
88Microretrognathia (HP:0000308)1.89350290
89Neurodegeneration (HP:0002180)1.86154568
90Premature graying of hair (HP:0002216)1.85976023
91Hyperammonemia (HP:0001987)1.84825112
92Horseshoe kidney (HP:0000085)1.82433793
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81707980
94Abnormality of serum amino acid levels (HP:0003112)1.81306570
95Small hand (HP:0200055)1.81238641
96Cerebellar dysplasia (HP:0007033)1.80235973
97Difficulty climbing stairs (HP:0003551)1.79589224
98Chorioretinal atrophy (HP:0000533)1.78157261
99Facial diplegia (HP:0001349)1.76565917
100High anterior hairline (HP:0009890)1.76418408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.84250092
2ZAK5.22605982
3PBK5.18278307
4MUSK3.38582491
5TESK23.24706534
6BUB13.05791294
7PIK3CG2.78992228
8BLK2.74422718
9SRPK12.31796840
10EPHA22.29884709
11STK161.88974076
12SIK11.80077724
13WNK41.79298228
14SMG11.75492865
15CDC71.63492010
16VRK11.58857155
17PAK41.56322023
18AURKA1.52299200
19AURKB1.50370101
20PLK11.49557080
21BRSK21.44616158
22RPS6KB21.43253358
23STK41.36696081
24EIF2AK31.35576402
25EPHA41.33959825
26EIF2AK11.32106570
27SIK21.28462680
28GRK61.27383227
29CDK91.23095969
30CHEK21.17741842
31MAPK151.17241232
32PDK21.12252013
33SCYL21.11583670
34RPS6KA51.09194354
35MARK31.08636656
36AKT21.06227014
37ATR1.05419413
38BRSK11.03964734
39MELK1.00456204
40MAP3K90.99699260
41VRK20.97797815
42FGFR40.96097361
43NUAK10.92500797
44ADRBK20.86376603
45NEK20.85519654
46DAPK30.83932213
47MAPK110.80203655
48CDK40.78631105
49NME10.75206785
50CDK60.74790428
51CAMKK20.73374436
52IRAK30.70130258
53CAMK40.69555400
54MAP3K120.69386724
55CHEK10.66523516
56CHUK0.65400305
57CDK70.64761023
58MKNK20.63443549
59PIM10.63361007
60NME20.63357169
61WEE10.59689729
62NEK10.59477742
63ACVR1B0.58405809
64ABL20.57952855
65LATS20.55585584
66MAP2K20.55406790
67STK390.54554909
68FRK0.52374057
69PLK30.49089717
70ICK0.49016052
71CDK120.48932921
72ERN10.48209027
73CSNK2A20.43793532
74SIK30.43190014
75CDK30.42728211
76CAMK1D0.42276510
77ERBB20.40187957
78CDK10.40075348
79CDK20.38053826
80BRD40.36950697
81PRKAA10.34684095
82CSNK2A10.33100573
83IKBKB0.32762788
84WNK10.30371265
85TXK0.29259314
86PTK60.29100913
87CSNK1E0.28146602
88PKN10.26097022
89ATM0.26004526
90PRKCI0.24870239
91MST40.24834353
92TTK0.23655805
93MAP3K80.23549036
94CAMK10.22072923
95DYRK30.21507070
96PRKCG0.20055364
97NEK60.19762065
98PLK40.18902931
99PDPK10.18120823
100MAP3K30.17360767

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.01075491
2Systemic lupus erythematosus_Homo sapiens_hsa053223.89962718
3Proteasome_Homo sapiens_hsa030503.15021404
4RNA polymerase_Homo sapiens_hsa030203.06195376
5Vitamin digestion and absorption_Homo sapiens_hsa049773.05617894
6DNA replication_Homo sapiens_hsa030303.05026741
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97262865
8Alcoholism_Homo sapiens_hsa050342.63518294
9Spliceosome_Homo sapiens_hsa030402.10752832
10Mismatch repair_Homo sapiens_hsa034302.03129871
11Pyrimidine metabolism_Homo sapiens_hsa002401.92954527
12Fanconi anemia pathway_Homo sapiens_hsa034601.89683180
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89266835
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80160989
15Base excision repair_Homo sapiens_hsa034101.77103286
16Arginine biosynthesis_Homo sapiens_hsa002201.75650927
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69253962
18One carbon pool by folate_Homo sapiens_hsa006701.67283254
19RNA transport_Homo sapiens_hsa030131.66182399
20Basal transcription factors_Homo sapiens_hsa030221.64437996
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61560675
22Nitrogen metabolism_Homo sapiens_hsa009101.51926850
23Lysine degradation_Homo sapiens_hsa003101.42412661
24Selenocompound metabolism_Homo sapiens_hsa004501.39803937
25Homologous recombination_Homo sapiens_hsa034401.38753109
26Non-homologous end-joining_Homo sapiens_hsa034501.38342170
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37602018
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.35844495
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.30497064
30Cell cycle_Homo sapiens_hsa041101.29207452
31Fatty acid degradation_Homo sapiens_hsa000711.27868862
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25921262
33Viral carcinogenesis_Homo sapiens_hsa052031.25795913
34Caffeine metabolism_Homo sapiens_hsa002321.25323535
35Pyruvate metabolism_Homo sapiens_hsa006201.24506695
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24101013
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23715665
38Tryptophan metabolism_Homo sapiens_hsa003801.21788812
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19425725
40mRNA surveillance pathway_Homo sapiens_hsa030151.16289447
41Fat digestion and absorption_Homo sapiens_hsa049751.10894223
42Ribosome_Homo sapiens_hsa030101.03460180
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02473621
44Arginine and proline metabolism_Homo sapiens_hsa003301.01645876
45Steroid biosynthesis_Homo sapiens_hsa001001.00524998
46Purine metabolism_Homo sapiens_hsa002301.00287603
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96627451
48Sphingolipid metabolism_Homo sapiens_hsa006000.96188934
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95403044
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92923442
51Glutathione metabolism_Homo sapiens_hsa004800.92870497
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91962718
53Nucleotide excision repair_Homo sapiens_hsa034200.90754106
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88543904
55Sulfur metabolism_Homo sapiens_hsa009200.87426578
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.86079990
57RNA degradation_Homo sapiens_hsa030180.85779903
58Carbon metabolism_Homo sapiens_hsa012000.84332474
59Histidine metabolism_Homo sapiens_hsa003400.79227803
60Biosynthesis of amino acids_Homo sapiens_hsa012300.76654396
61Fructose and mannose metabolism_Homo sapiens_hsa000510.76478045
62Lysosome_Homo sapiens_hsa041420.75992278
63Linoleic acid metabolism_Homo sapiens_hsa005910.74503020
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.73506921
65Complement and coagulation cascades_Homo sapiens_hsa046100.73237828
66Folate biosynthesis_Homo sapiens_hsa007900.73122926
67Huntingtons disease_Homo sapiens_hsa050160.72230077
68Mineral absorption_Homo sapiens_hsa049780.70398615
69Galactose metabolism_Homo sapiens_hsa000520.69136610
70Chemical carcinogenesis_Homo sapiens_hsa052040.64601588
71Metabolic pathways_Homo sapiens_hsa011000.62543801
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.61092557
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59124498
74N-Glycan biosynthesis_Homo sapiens_hsa005100.58871599
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57354385
76Hedgehog signaling pathway_Homo sapiens_hsa043400.57009703
77Other glycan degradation_Homo sapiens_hsa005110.56655490
78Fatty acid metabolism_Homo sapiens_hsa012120.53140304
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51128241
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50102699
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49036972
82Ovarian steroidogenesis_Homo sapiens_hsa049130.49012960
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48286276
84Basal cell carcinoma_Homo sapiens_hsa052170.47625312
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46341376
86Peroxisome_Homo sapiens_hsa041460.45516331
87PPAR signaling pathway_Homo sapiens_hsa033200.45292387
88Fatty acid elongation_Homo sapiens_hsa000620.43988541
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41457279
90Oxidative phosphorylation_Homo sapiens_hsa001900.41082668
91Bile secretion_Homo sapiens_hsa049760.37835837
92Parkinsons disease_Homo sapiens_hsa050120.36712485
93ABC transporters_Homo sapiens_hsa020100.34840946
94Epstein-Barr virus infection_Homo sapiens_hsa051690.34736416
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.34205844
96p53 signaling pathway_Homo sapiens_hsa041150.32870478
97Ether lipid metabolism_Homo sapiens_hsa005650.31921649
98Glycerolipid metabolism_Homo sapiens_hsa005610.30421754
99Hippo signaling pathway_Homo sapiens_hsa043900.30146896
100beta-Alanine metabolism_Homo sapiens_hsa004100.29714596

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