KRT18P40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of uterine smooth muscle contraction (GO:0070474)9.92042925
2tachykinin receptor signaling pathway (GO:0007217)8.51856882
3regulation of uterine smooth muscle contraction (GO:0070472)8.02544734
4positive regulation of protein homodimerization activity (GO:0090073)7.14131050
5regulation of mitochondrial translation (GO:0070129)5.92109577
6viral transcription (GO:0019083)5.78862582
7translational termination (GO:0006415)5.53730966
8regulation of feeding behavior (GO:0060259)5.10529016
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.81815438
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.80475477
11cotranslational protein targeting to membrane (GO:0006613)4.72820098
12translational elongation (GO:0006414)4.70181950
13protein targeting to ER (GO:0045047)4.68005408
14positive regulation of T cell cytokine production (GO:0002726)4.59142731
15mitochondrial calcium ion transport (GO:0006851)4.58123092
16ribosomal small subunit biogenesis (GO:0042274)4.50882309
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.46919871
18positive regulation of smooth muscle contraction (GO:0045987)4.44131402
19cellular response to nitric oxide (GO:0071732)4.43248524
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.42649931
21protein localization to endoplasmic reticulum (GO:0070972)4.42288220
22cellular protein complex disassembly (GO:0043624)4.42272164
23chaperone-mediated protein transport (GO:0072321)4.38827870
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22173451
25viral life cycle (GO:0019058)4.15699304
26purine deoxyribonucleotide catabolic process (GO:0009155)4.12761738
27translational initiation (GO:0006413)4.07903590
28NIK/NF-kappaB signaling (GO:0038061)4.04132136
29response to pheromone (GO:0019236)4.01420981
30grooming behavior (GO:0007625)3.86794809
31maturation of SSU-rRNA (GO:0030490)3.85282673
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.82733466
33ATP synthesis coupled proton transport (GO:0015986)3.82733466
34purine nucleotide salvage (GO:0032261)3.82001042
35peptidyl-arginine omega-N-methylation (GO:0035247)3.79154315
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.77661770
37purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.74673111
38ncRNA 3-end processing (GO:0043628)3.68541205
39positive regulation of growth hormone secretion (GO:0060124)3.64777540
40proteasome assembly (GO:0043248)3.63435026
41ribosomal small subunit assembly (GO:0000028)3.60856302
42protein complex disassembly (GO:0043241)3.56864171
43deoxyribose phosphate catabolic process (GO:0046386)3.55408325
44ubiquinone biosynthetic process (GO:0006744)3.52058240
45ribosomal large subunit biogenesis (GO:0042273)3.49922370
46macromolecular complex disassembly (GO:0032984)3.44584359
47positive regulation of muscle contraction (GO:0045933)3.42567784
48hyperosmotic salinity response (GO:0042538)3.38071108
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.37413643
50regulation of cellular amino acid metabolic process (GO:0006521)3.36423391
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35069519
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35069519
53protein homotrimerization (GO:0070207)3.31524278
54Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31403917
55pantothenate metabolic process (GO:0015939)3.29482652
56regulation of oxidative phosphorylation (GO:0002082)3.28323759
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.23436311
58regulation of gonadotropin secretion (GO:0032276)3.23118409
59protein targeting to membrane (GO:0006612)3.22474601
60translation (GO:0006412)3.18530506
61negative regulation of telomere maintenance (GO:0032205)3.16125031
62ribonucleoprotein complex biogenesis (GO:0022613)3.14231607
63purine deoxyribonucleotide metabolic process (GO:0009151)3.13953259
64regulation of immunoglobulin secretion (GO:0051023)3.13756069
65deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.11052773
66G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.10807973
67ubiquinone metabolic process (GO:0006743)3.10489280
68response to nitric oxide (GO:0071731)3.08734799
69electron transport chain (GO:0022900)3.04597145
70respiratory electron transport chain (GO:0022904)3.03468155
71positive regulation of heart rate (GO:0010460)3.02760308
72formation of translation preinitiation complex (GO:0001731)3.01774576
73DNA deamination (GO:0045006)3.01384242
74peptidyl-arginine N-methylation (GO:0035246)3.01191509
75peptidyl-arginine methylation (GO:0018216)3.01191509
76actin nucleation (GO:0045010)2.99491675
77regulation of protein homodimerization activity (GO:0043496)2.96442197
78regulation of dopamine metabolic process (GO:0042053)2.94412356
79regulation of catecholamine metabolic process (GO:0042069)2.94412356
80DNA damage response, detection of DNA damage (GO:0042769)2.93327718
81histone arginine methylation (GO:0034969)2.91872723
82regulation of translational termination (GO:0006449)2.90588687
83quinone biosynthetic process (GO:1901663)2.90346684
84coenzyme A biosynthetic process (GO:0015937)2.90002578
85deoxyribonucleotide catabolic process (GO:0009264)2.85063155
86positive regulation of blood pressure (GO:0045777)2.84854758
87hepatocyte apoptotic process (GO:0097284)2.84777598
88regulation of T cell cytokine production (GO:0002724)2.84665069
89protein refolding (GO:0042026)2.82709253
90coenzyme A metabolic process (GO:0015936)2.82466235
91artery smooth muscle contraction (GO:0014824)2.78285760
92regulation of cellular amine metabolic process (GO:0033238)2.78254725
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73999295
94nuclear-transcribed mRNA catabolic process (GO:0000956)2.73190276
95metallo-sulfur cluster assembly (GO:0031163)2.71637947
96iron-sulfur cluster assembly (GO:0016226)2.71637947
97regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.69310093
98negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69187024
99rRNA transcription (GO:0009303)2.68015076
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.67491104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.10620266
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.14060594
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.88030059
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.26169381
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.13587577
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.96482270
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82851380
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72537396
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71345095
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.70926835
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.49050440
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33288992
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.27976206
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.22174913
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04257031
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.00514635
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95015766
18VDR_22108803_ChIP-Seq_LS180_Human1.92569490
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90573952
20YY1_22570637_ChIP-Seq_MALME-3M_Human1.85666524
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82976115
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82936838
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81633018
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.75504106
25FOXP3_21729870_ChIP-Seq_TREG_Human1.72775004
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69475771
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59641665
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58823089
29ERA_21632823_ChIP-Seq_H3396_Human1.58135237
30VDR_23849224_ChIP-Seq_CD4+_Human1.57031267
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56862228
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52226860
33TTF2_22483619_ChIP-Seq_HELA_Human1.51281838
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40958625
35RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35960675
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35456734
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31768641
38TP53_22573176_ChIP-Seq_HFKS_Human1.30534674
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.30102295
40PHF8_20622854_ChIP-Seq_HELA_Human1.26129225
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.25690681
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24349535
43SA1_27219007_Chip-Seq_Bcells_Human1.22922605
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22682658
45STAT1_20625510_ChIP-Seq_HELA_Human1.18732822
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17317660
47XRN2_22483619_ChIP-Seq_HELA_Human1.17247881
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.16792668
49BCL6_27268052_Chip-Seq_Bcells_Human1.16659128
50ERG_20517297_ChIP-Seq_VCAP_Human1.15494577
51BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.13820403
52CTCF_20526341_ChIP-Seq_ESCs_Human1.13581873
53OCT4_20526341_ChIP-Seq_ESCs_Human1.12709956
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12324866
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12220170
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11860296
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11660042
58NCOR_22424771_ChIP-Seq_293T_Human1.11446868
59BCOR_27268052_Chip-Seq_Bcells_Human1.10481708
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10168667
61SPI1_20517297_ChIP-Seq_HL60_Human1.06591935
62GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05464399
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05126385
64P68_20966046_ChIP-Seq_HELA_Human1.05005115
65PHF8_20622853_ChIP-Seq_HELA_Human1.03281594
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.03035727
67DCP1A_22483619_ChIP-Seq_HELA_Human1.00458640
68FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00371830
69RBPJ_21746931_ChIP-Seq_IB4_Human1.00369675
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00152933
71CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98954370
72GATA3_26560356_Chip-Seq_TH2_Human0.98700758
73GATA3_21867929_ChIP-Seq_TH1_Mouse0.98334921
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97835156
75P300_27268052_Chip-Seq_Bcells_Human0.97822058
76SOX2_21211035_ChIP-Seq_LN229_Human0.97130039
77FOXH1_21741376_ChIP-Seq_EPCs_Human0.94829802
78MYC_18940864_ChIP-ChIP_HL60_Human0.94522763
79E2F1_20622854_ChIP-Seq_HELA_Human0.93892042
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93210544
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.93210544
82LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93166983
83RAC3_21632823_ChIP-Seq_H3396_Human0.92803483
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92344175
85GATA6_21074721_ChIP-Seq_CACO-2_Human0.91979707
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91750452
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.88935578
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88723802
89TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86755168
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86724001
91SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.86348772
92ETV1_20927104_ChIP-Seq_GIST48_Human0.86177005
93AR_20517297_ChIP-Seq_VCAP_Human0.85752419
94CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85742901
95TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.85348181
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83777852
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83557175
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82629596
99P53_21459846_ChIP-Seq_SAOS-2_Human0.82493158
100NFYB_21822215_ChIP-Seq_K562_Human0.81468742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.67823938
2MP0000372_irregular_coat_pigmentation4.89741317
3MP0003806_abnormal_nucleotide_metabolis4.72762206
4MP0005451_abnormal_body_composition4.51225575
5MP0002132_abnormal_respiratory_system3.93362351
6MP0009379_abnormal_foot_pigmentation3.12540198
7MP0002736_abnormal_nociception_after2.92629125
8MP0002163_abnormal_gland_morphology2.89925071
9MP0008875_abnormal_xenobiotic_pharmacok2.70847986
10MP0005410_abnormal_fertilization2.52442729
11MP0002277_abnormal_respiratory_mucosa2.50042155
12MP0004381_abnormal_hair_follicle2.46533484
13MP0005671_abnormal_response_to2.45710342
14MP0001873_stomach_inflammation2.44312564
15MP0002102_abnormal_ear_morphology2.35250386
16MP0003763_abnormal_thymus_physiology2.33689694
17MP0002254_reproductive_system_inflammat2.32334965
18MP0003183_abnormal_peptide_metabolism2.05728686
19MP0002138_abnormal_hepatobiliary_system1.99003980
20MP0006292_abnormal_olfactory_placode1.96724172
21MP0006035_abnormal_mitochondrial_morpho1.81413860
22MP0001968_abnormal_touch/_nociception1.72816233
23MP0003786_premature_aging1.66670680
24MP0005377_hearing/vestibular/ear_phenot1.53626329
25MP0003878_abnormal_ear_physiology1.53626329
26MP0009840_abnormal_foam_cell1.39216742
27MP0003718_maternal_effect1.37748588
28MP0000631_abnormal_neuroendocrine_gland1.37736393
29MP0003880_abnormal_central_pattern1.37332483
30MP0005379_endocrine/exocrine_gland_phen1.36775178
31MP0006036_abnormal_mitochondrial_physio1.34866978
32MP0003252_abnormal_bile_duct1.33746752
33MP0008872_abnormal_physiological_respon1.32919015
34MP0005083_abnormal_biliary_tract1.28470948
35MP0009697_abnormal_copulation1.26328198
36MP0003693_abnormal_embryo_hatching1.26286142
37MP0001881_abnormal_mammary_gland1.25438475
38MP0002234_abnormal_pharynx_morphology1.25421977
39MP0004147_increased_porphyrin_level1.23747309
40MP0005266_abnormal_metabolism1.20119885
41MP0005075_abnormal_melanosome_morpholog1.18199055
42MP0005636_abnormal_mineral_homeostasis1.16552353
43MP0010386_abnormal_urinary_bladder1.16100180
44MP0003950_abnormal_plasma_membrane1.15198378
45MP0002733_abnormal_thermal_nociception1.12795054
46MP0004133_heterotaxia1.11959903
47MP0001501_abnormal_sleep_pattern1.09385118
48MP0008004_abnormal_stomach_pH1.04557476
49MP0001765_abnormal_ion_homeostasis1.03603660
50MP0003724_increased_susceptibility_to0.99774977
51MP0003866_abnormal_defecation0.98853864
52MP0002653_abnormal_ependyma_morphology0.92162045
53MP0005025_abnormal_response_to0.91767121
54MP0000604_amyloidosis0.89333993
55MP0006276_abnormal_autonomic_nervous0.87007147
56MP0003938_abnormal_ear_development0.86295439
57MP0002210_abnormal_sex_determination0.85663929
58MP0001905_abnormal_dopamine_level0.84666814
59MP0005551_abnormal_eye_electrophysiolog0.84076372
60MP0001666_abnormal_nutrient_absorption0.82937562
61MP0003698_abnormal_male_reproductive0.80979869
62MP0004019_abnormal_vitamin_homeostasis0.80588670
63MP0000490_abnormal_crypts_of0.79294781
64MP0009333_abnormal_splenocyte_physiolog0.79103059
65MP0002136_abnormal_kidney_physiology0.78900658
66MP0000230_abnormal_systemic_arterial0.77348024
67MP0005085_abnormal_gallbladder_physiolo0.77145296
68MP0001963_abnormal_hearing_physiology0.76491639
69MP0002693_abnormal_pancreas_physiology0.75370947
70MP0000358_abnormal_cell_content/0.75108505
71MP0002723_abnormal_immune_serum0.74606348
72MP0002876_abnormal_thyroid_physiology0.73903197
73MP0003186_abnormal_redox_activity0.72554601
74MP0000026_abnormal_inner_ear0.72102968
75MP0001119_abnormal_female_reproductive0.71701488
76MP0000647_abnormal_sebaceous_gland0.71210030
77MP0001929_abnormal_gametogenesis0.70831401
78MP0005187_abnormal_penis_morphology0.70178135
79MP0002148_abnormal_hypersensitivity_rea0.69372834
80MP0001542_abnormal_bone_strength0.68575598
81MP0005171_absent_coat_pigmentation0.66477849
82MP0004885_abnormal_endolymph0.66101174
83MP0000383_abnormal_hair_follicle0.66073410
84MP0002837_dystrophic_cardiac_calcinosis0.65038964
85MP0003936_abnormal_reproductive_system0.64654989
86MP0002735_abnormal_chemical_nociception0.64196770
87MP0009643_abnormal_urine_homeostasis0.63491066
88MP0001663_abnormal_digestive_system0.62697265
89MP0001293_anophthalmia0.62507376
90MP0003011_delayed_dark_adaptation0.62328560
91MP0000049_abnormal_middle_ear0.62299892
92MP0000627_abnormal_mammary_gland0.57346129
93MP0000653_abnormal_sex_gland0.56842266
94MP0002933_joint_inflammation0.55602539
95MP0001800_abnormal_humoral_immune0.55498837
96MP0001286_abnormal_eye_development0.55395538
97MP0001970_abnormal_pain_threshold0.55056760
98MP0000716_abnormal_immune_system0.54213245
99MP0001819_abnormal_immune_cell0.53961863
100MP0001485_abnormal_pinna_reflex0.52014677

Predicted human phenotypes

RankGene SetZ-score
1Sensory axonal neuropathy (HP:0003390)5.85487674
2Dysphonia (HP:0001618)5.64409497
3Elevated erythrocyte sedimentation rate (HP:0003565)4.98187303
43-Methylglutaconic aciduria (HP:0003535)4.83914152
5Testicular atrophy (HP:0000029)4.76986008
6Concave nail (HP:0001598)4.29905619
7Acute necrotizing encephalopathy (HP:0006965)3.92685550
8Abnormality of B cell number (HP:0010975)3.82059847
9Flat capital femoral epiphysis (HP:0003370)3.79319579
10B lymphocytopenia (HP:0010976)3.61937799
11Acute encephalopathy (HP:0006846)3.52090158
12Limb dystonia (HP:0002451)3.48489159
13Abnormal mitochondria in muscle tissue (HP:0008316)3.43207728
14IgM deficiency (HP:0002850)3.30755340
15Microvesicular hepatic steatosis (HP:0001414)3.23662810
16Hypoplasia of the pons (HP:0012110)3.19671302
17IgG deficiency (HP:0004315)3.12366127
18Progressive macrocephaly (HP:0004481)3.03449400
19Abnormal biliary tract physiology (HP:0012439)3.02055288
20Bile duct proliferation (HP:0001408)3.02055288
21Conical tooth (HP:0000698)2.96704038
22Dyschromatopsia (HP:0007641)2.86907723
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.85389068
24Abnormality of the renal cortex (HP:0011035)2.84578971
25Congenital stationary night blindness (HP:0007642)2.79831457
26Abnormality of the pons (HP:0007361)2.78679222
27Macrocytic anemia (HP:0001972)2.73968868
28Severe visual impairment (HP:0001141)2.73218205
29Polydipsia (HP:0001959)2.72376805
30Abnormal drinking behavior (HP:0030082)2.72376805
31Rough bone trabeculation (HP:0100670)2.66979392
32Mitochondrial inheritance (HP:0001427)2.61428972
33Abnormal number of erythroid precursors (HP:0012131)2.56729275
34Abnormality of cells of the erythroid lineage (HP:0012130)2.53166217
35Renal cortical cysts (HP:0000803)2.49769385
36Malnutrition (HP:0004395)2.44558289
37Severe combined immunodeficiency (HP:0004430)2.42778041
38Diastasis recti (HP:0001540)2.38905749
39Increased CSF lactate (HP:0002490)2.37551955
40Hyperlipoproteinemia (HP:0010980)2.36736231
41Nephronophthisis (HP:0000090)2.35294068
42Aplastic anemia (HP:0001915)2.35021522
43Cerebral edema (HP:0002181)2.34994002
44Poor speech (HP:0002465)2.34496273
45Abnormal hemoglobin (HP:0011902)2.33898300
46Thoracic kyphosis (HP:0002942)2.33804564
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32865769
48Congenital sensorineural hearing impairment (HP:0008527)2.31416077
49Cerebral hypomyelination (HP:0006808)2.31011917
50Paralysis (HP:0003470)2.28866279
51Polyuria (HP:0000103)2.25787340
52Leukodystrophy (HP:0002415)2.19450946
53Tubular atrophy (HP:0000092)2.19264279
54Pallor (HP:0000980)2.18904530
55Resting tremor (HP:0002322)2.16739384
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16584171
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16490302
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16490302
59Abnormal trabecular bone morphology (HP:0100671)2.13582704
60Prostate neoplasm (HP:0100787)2.12383822
61Fibular aplasia (HP:0002990)2.11901466
62Exercise intolerance (HP:0003546)2.10544936
63Parakeratosis (HP:0001036)2.08800450
64Hyperglycinuria (HP:0003108)2.05920555
65Pancytopenia (HP:0001876)2.04136112
66Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.03994899
67Stomatitis (HP:0010280)2.03008827
68Palpebral edema (HP:0100540)2.00919852
69Distal arthrogryposis (HP:0005684)1.99240305
70Type I diabetes mellitus (HP:0100651)1.98357595
71Sparse eyelashes (HP:0000653)1.97872864
72Abnormality of renal excretion (HP:0011036)1.95950269
73Increased intramyocellular lipid droplets (HP:0012240)1.95861565
74Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95472703
75Respiratory difficulties (HP:0002880)1.94080268
76Abnormality of the renal medulla (HP:0100957)1.93163912
77Chronic diarrhea (HP:0002028)1.92211918
78Abnormal urine output (HP:0012590)1.91502636
79Bilateral microphthalmos (HP:0007633)1.89809880
80Optic disc pallor (HP:0000543)1.88833814
81Microretrognathia (HP:0000308)1.86553147
82Abnormality of the heme biosynthetic pathway (HP:0010472)1.84773578
83Abnormal rod and cone electroretinograms (HP:0008323)1.84375314
84Tubulointerstitial fibrosis (HP:0005576)1.84283704
85Abnormality of the epiphysis of the femoral head (HP:0010574)1.82472913
86Impaired proprioception (HP:0010831)1.82286934
87Poor head control (HP:0002421)1.82149014
88Cellular immunodeficiency (HP:0005374)1.81304326
89Combined immunodeficiency (HP:0005387)1.80514430
90Xanthomatosis (HP:0000991)1.80115488
91Cortical visual impairment (HP:0100704)1.79747966
92Premature graying of hair (HP:0002216)1.76283155
93Type 2 muscle fiber atrophy (HP:0003554)1.76175198
94Oligodontia (HP:0000677)1.75091435
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74941717
96Bony spicule pigmentary retinopathy (HP:0007737)1.74757933
97Abnormality of the fovea (HP:0000493)1.73281661
98Nasolacrimal duct obstruction (HP:0000579)1.73171786
99Spastic paraparesis (HP:0002313)1.72694932
100Gastrointestinal stroma tumor (HP:0100723)1.71291769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL26.90982674
2TESK25.47923998
3TLK14.28259724
4TESK13.90719515
5LIMK13.02140268
6KDR2.96943867
7PASK2.73844952
8WNK42.61007940
9EIF2AK12.56992285
10NUAK12.27373991
11TAOK22.20154630
12MAP3K122.13193034
13VRK12.10968630
14EPHA22.05764073
15ZAK1.96045324
16ITK1.69639457
17CDK191.69038902
18MYLK1.65674526
19EIF2AK31.61456058
20NEK11.54343671
21VRK21.42997705
22ZAP701.35167343
23INSRR1.29421599
24STK391.28045644
25CSK1.24791626
26NME21.19906748
27PINK11.19759292
28OXSR11.17827192
29BCKDK1.17405913
30ADRBK21.15759287
31DYRK31.12879109
32TEC1.11896877
33ERN11.10067721
34BRSK21.07686406
35ILK1.02783509
36RPS6KB20.91268808
37CAMKK20.88736676
38DAPK10.87346420
39TIE10.86107168
40TXK0.77624127
41ABL20.74235298
42CAMKK10.73917798
43BTK0.70093900
44GRK10.65667907
45MAPKAPK30.62577756
46GRK60.61876605
47MAP2K20.61752589
48AURKA0.59243020
49SRPK10.58177867
50CDK120.57451481
51PRKCQ0.56052648
52PRPF4B0.51427393
53DAPK30.49640426
54SYK0.49628516
55LCK0.49336581
56BLK0.48595396
57PRKAA20.47427628
58FLT30.47059990
59PRKCZ0.46772334
60MST40.45638786
61FES0.44212127
62AURKB0.41697625
63BRSK10.39623819
64PKN10.37317404
65DYRK20.35939479
66ADRBK10.35253979
67PRKCD0.33590636
68PDK20.33110113
69AKT20.32120460
70PLK10.31882356
71CAMK10.30683006
72PAK10.30265328
73PRKACA0.29434169
74CAMK2B0.29392686
75CAMK2G0.29003278
76HIPK20.28907167
77RPS6KA40.28851791
78MAPKAPK20.27674308
79RPS6KA50.27604025
80NME10.27385781
81PRKD10.27214092
82PAK40.26300850
83PRKCA0.25596516
84INSR0.25447092
85BMX0.23840249
86IKBKB0.23592056
87ROCK10.23106783
88CSNK2A10.23050949
89NEK60.21594284
90PLK30.21219015
91PIK3CG0.20293227
92IGF1R0.19922972
93TYRO30.19892427
94CHEK20.19779188
95PRKCI0.19255368
96IKBKE0.19155748
97PRKD20.16858417
98MAP3K110.16723923
99MAP3K80.15834312
100CAMK1D0.15637494

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.73173751
2Proteasome_Homo sapiens_hsa030504.33523537
3Primary immunodeficiency_Homo sapiens_hsa053403.62295829
4Oxidative phosphorylation_Homo sapiens_hsa001903.50766383
5Parkinsons disease_Homo sapiens_hsa050122.89190288
6Sulfur relay system_Homo sapiens_hsa041222.87050979
7Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.35885893
8Caffeine metabolism_Homo sapiens_hsa002322.18582715
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.14332534
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96218171
11Huntingtons disease_Homo sapiens_hsa050161.88059358
12Sulfur metabolism_Homo sapiens_hsa009201.86320116
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.81656908
14Antigen processing and presentation_Homo sapiens_hsa046121.78718380
15Folate biosynthesis_Homo sapiens_hsa007901.73992732
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69137845
17Alzheimers disease_Homo sapiens_hsa050101.66528965
18Chemical carcinogenesis_Homo sapiens_hsa052041.64115322
19One carbon pool by folate_Homo sapiens_hsa006701.63109051
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56670357
21Cardiac muscle contraction_Homo sapiens_hsa042601.55916820
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.51214123
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48406400
24Starch and sucrose metabolism_Homo sapiens_hsa005001.46005316
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44401446
26Protein export_Homo sapiens_hsa030601.41536509
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37127492
28Non-homologous end-joining_Homo sapiens_hsa034501.33216370
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32315387
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21530117
31Regulation of autophagy_Homo sapiens_hsa041401.20142442
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17794150
33Histidine metabolism_Homo sapiens_hsa003401.14352320
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12774480
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.12748868
36T cell receptor signaling pathway_Homo sapiens_hsa046601.11361972
37Tryptophan metabolism_Homo sapiens_hsa003801.08505677
38Fanconi anemia pathway_Homo sapiens_hsa034601.05769957
39Collecting duct acid secretion_Homo sapiens_hsa049661.04526611
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02942967
41Retinol metabolism_Homo sapiens_hsa008301.01418282
42Spliceosome_Homo sapiens_hsa030401.01407917
43Hematopoietic cell lineage_Homo sapiens_hsa046400.99774454
44Selenocompound metabolism_Homo sapiens_hsa004500.96899288
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96855354
46Base excision repair_Homo sapiens_hsa034100.96643464
47Legionellosis_Homo sapiens_hsa051340.94045867
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93683965
49Pyrimidine metabolism_Homo sapiens_hsa002400.93053356
50Protein digestion and absorption_Homo sapiens_hsa049740.88715860
51RNA degradation_Homo sapiens_hsa030180.86698078
52Homologous recombination_Homo sapiens_hsa034400.84427408
53Linoleic acid metabolism_Homo sapiens_hsa005910.80862656
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79782815
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.78944882
56Peroxisome_Homo sapiens_hsa041460.76377977
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75738519
58Glutathione metabolism_Homo sapiens_hsa004800.72642603
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71381697
60Purine metabolism_Homo sapiens_hsa002300.70654838
61DNA replication_Homo sapiens_hsa030300.69401867
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67276447
63Metabolic pathways_Homo sapiens_hsa011000.66264490
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.64727866
65Galactose metabolism_Homo sapiens_hsa000520.64190562
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60992149
67Basal transcription factors_Homo sapiens_hsa030220.53870494
68Butanoate metabolism_Homo sapiens_hsa006500.53851846
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51058633
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.50922845
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49707598
72RNA polymerase_Homo sapiens_hsa030200.48724478
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47513732
74Malaria_Homo sapiens_hsa051440.46555342
75Tyrosine metabolism_Homo sapiens_hsa003500.45922477
76RNA transport_Homo sapiens_hsa030130.45675167
77Fatty acid biosynthesis_Homo sapiens_hsa000610.44519503
78Phototransduction_Homo sapiens_hsa047440.40800803
79Shigellosis_Homo sapiens_hsa051310.40339698
80beta-Alanine metabolism_Homo sapiens_hsa004100.38503331
81Measles_Homo sapiens_hsa051620.33479911
82Arachidonic acid metabolism_Homo sapiens_hsa005900.31384582
83Graft-versus-host disease_Homo sapiens_hsa053320.30524754
84Apoptosis_Homo sapiens_hsa042100.27758052
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26260127
86Circadian rhythm_Homo sapiens_hsa047100.25219929
87Epstein-Barr virus infection_Homo sapiens_hsa051690.25106671
88Allograft rejection_Homo sapiens_hsa053300.23756550
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23590615
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23548111
91Mineral absorption_Homo sapiens_hsa049780.21581938
92Renin-angiotensin system_Homo sapiens_hsa046140.20166184
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19453860
94Olfactory transduction_Homo sapiens_hsa047400.19413105
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18868738
96Fatty acid degradation_Homo sapiens_hsa000710.18145569
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17987962
98Propanoate metabolism_Homo sapiens_hsa006400.16540494
99Autoimmune thyroid disease_Homo sapiens_hsa053200.16433574
100Mismatch repair_Homo sapiens_hsa034300.15035728

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