KRT18P41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aggressive behavior (GO:0002118)6.05245925
2deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.85128277
3DNA deamination (GO:0045006)4.64203070
4regulation of female receptivity (GO:0045924)4.44594163
5purine deoxyribonucleotide catabolic process (GO:0009155)4.39421508
6pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.33743885
7deoxyribonucleotide catabolic process (GO:0009264)4.19844177
8female mating behavior (GO:0060180)4.19435433
9definitive hemopoiesis (GO:0060216)4.14836659
10deoxyribose phosphate catabolic process (GO:0046386)3.99876571
11positive regulation of prostaglandin secretion (GO:0032308)3.91756643
12respiratory chain complex IV assembly (GO:0008535)3.90044760
13regulation of transmission of nerve impulse (GO:0051969)3.84967497
14hyperosmotic salinity response (GO:0042538)3.83284246
15rRNA catabolic process (GO:0016075)3.70883406
16cytochrome complex assembly (GO:0017004)3.66555397
17purine deoxyribonucleotide metabolic process (GO:0009151)3.60500827
18pyrimidine nucleotide catabolic process (GO:0006244)3.54037769
19mature B cell differentiation involved in immune response (GO:0002313)3.51383512
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.49003723
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.49003723
22protein complex biogenesis (GO:0070271)3.45083592
23purine nucleotide salvage (GO:0032261)3.42684778
24purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.36577269
25daunorubicin metabolic process (GO:0044597)3.32790670
26polyketide metabolic process (GO:0030638)3.32790670
27doxorubicin metabolic process (GO:0044598)3.32790670
28regulation of skeletal muscle contraction (GO:0014819)3.31578400
29endothelium development (GO:0003158)3.27450631
30maternal behavior (GO:0042711)3.25290231
31deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.24889130
32negative regulation of macrophage differentiation (GO:0045650)3.23948504
33branched-chain amino acid catabolic process (GO:0009083)3.19067236
34purine-containing compound salvage (GO:0043101)3.16183254
352-deoxyribonucleotide metabolic process (GO:0009394)3.12810739
36parental behavior (GO:0060746)3.10179404
37grooming behavior (GO:0007625)3.09234852
38response to interferon-beta (GO:0035456)3.08197893
39Peyers patch development (GO:0048541)3.06161979
40mucosal-associated lymphoid tissue development (GO:0048537)3.06161979
41regulation of mitochondrial translation (GO:0070129)3.05529464
42negative regulation of B cell apoptotic process (GO:0002903)3.03102330
43regulation of prostaglandin secretion (GO:0032306)3.01772106
44deoxyribose phosphate metabolic process (GO:0019692)2.98207149
45aminoglycoside antibiotic metabolic process (GO:0030647)2.95773544
46positive regulation of fatty acid biosynthetic process (GO:0045723)2.94575125
47mitochondrial respiratory chain complex assembly (GO:0033108)2.93640705
48base-excision repair, AP site formation (GO:0006285)2.87766057
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86443298
50seminiferous tubule development (GO:0072520)2.85808672
51autophagic vacuole fusion (GO:0000046)2.85361912
52DNA dealkylation (GO:0035510)2.84321073
53regulation of RIG-I signaling pathway (GO:0039535)2.83317255
54monoamine transport (GO:0015844)2.83024134
55pseudouridine synthesis (GO:0001522)2.82317112
56branched-chain amino acid metabolic process (GO:0009081)2.82073096
57positive regulation of antigen processing and presentation (GO:0002579)2.81580243
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79888877
59regulation of B cell apoptotic process (GO:0002902)2.77998437
60DNA integration (GO:0015074)2.77077706
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75619075
62mitochondrial respiratory chain complex I assembly (GO:0032981)2.75619075
63NADH dehydrogenase complex assembly (GO:0010257)2.75619075
64positive regulation of glycolytic process (GO:0045821)2.75058762
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71969671
66mannosylation (GO:0097502)2.71370294
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.69721283
68positive regulation of amino acid transport (GO:0051957)2.69171206
69deoxyribonucleotide metabolic process (GO:0009262)2.66736041
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62539536
71cellular response to exogenous dsRNA (GO:0071360)2.61526628
72positive regulation of organic acid transport (GO:0032892)2.61099008
73positive regulation of icosanoid secretion (GO:0032305)2.60224570
74ribosomal small subunit assembly (GO:0000028)2.60063240
75ATP synthesis coupled proton transport (GO:0015986)2.59847953
76energy coupled proton transport, down electrochemical gradient (GO:0015985)2.59847953
77positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.59615057
78mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.59240976
79response to testosterone (GO:0033574)2.58727763
80iron-sulfur cluster assembly (GO:0016226)2.58258189
81metallo-sulfur cluster assembly (GO:0031163)2.58258189
82positive regulation of fatty acid transport (GO:2000193)2.55510563
83response to pheromone (GO:0019236)2.55449711
84regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.54387923
85positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.54387923
86pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.54115246
87negative regulation of telomere maintenance (GO:0032205)2.53939740
88positive regulation of granulocyte differentiation (GO:0030854)2.53050570
89purinergic nucleotide receptor signaling pathway (GO:0035590)2.51514364
90positive regulation of protein sumoylation (GO:0033235)2.51312886
91rRNA modification (GO:0000154)2.50104006
92cytidine metabolic process (GO:0046087)2.49903809
93cytidine catabolic process (GO:0006216)2.49903809
94cytidine deamination (GO:0009972)2.49903809
95positive regulation of B cell differentiation (GO:0045579)2.49786804
96regulation of antigen processing and presentation (GO:0002577)2.49511650
97negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.48893894
98positive regulation of TOR signaling (GO:0032008)2.47549090
99negative regulation of neurological system process (GO:0031645)2.46755376
100piRNA metabolic process (GO:0034587)2.45122653

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.28867500
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.39015929
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71738079
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.26947445
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.09813285
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.01295924
7SCL_19346495_ChIP-Seq_HPC-7_Human2.76597676
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67539889
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.63852654
10GATA1_22025678_ChIP-Seq_K562_Human2.59389058
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58873619
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54673294
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.48441300
14ZNF274_21170338_ChIP-Seq_K562_Hela2.38750396
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.33268204
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32345131
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.29449209
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24988537
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19269776
20VDR_23849224_ChIP-Seq_CD4+_Human2.14317303
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.12762816
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10388794
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99982237
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85028875
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82108243
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78485258
27FOXP3_21729870_ChIP-Seq_TREG_Human1.77019723
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74544785
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.72769587
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72478372
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71386102
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.65365313
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.62963399
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61345315
35ELF1_20517297_ChIP-Seq_JURKAT_Human1.60494975
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60054057
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54723344
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51320108
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.49586426
40VDR_22108803_ChIP-Seq_LS180_Human1.46680579
41TP53_22573176_ChIP-Seq_HFKS_Human1.44143730
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36813114
43P300_27268052_Chip-Seq_Bcells_Human1.34042126
44MYC_18940864_ChIP-ChIP_HL60_Human1.31965362
45AR_20517297_ChIP-Seq_VCAP_Human1.30967550
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30340613
47MYB_26560356_Chip-Seq_TH2_Human1.28640785
48NANOG_20526341_ChIP-Seq_ESCs_Human1.27405448
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25138994
50SPI1_20517297_ChIP-Seq_HL60_Human1.24835976
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23535792
52GATA3_27048872_Chip-Seq_THYMUS_Human1.22765491
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22333730
54GATA3_26560356_Chip-Seq_TH2_Human1.22126414
55BCL6_27268052_Chip-Seq_Bcells_Human1.21061266
56GABP_19822575_ChIP-Seq_HepG2_Human1.20926685
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.19498230
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18403196
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15578280
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15048866
61SPI1_23547873_ChIP-Seq_NB4_Human1.14561851
62CIITA_25753668_ChIP-Seq_RAJI_Human1.13602670
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13085168
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.11902934
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11862653
66FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11606683
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11392299
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11229159
69STAT1_20625510_ChIP-Seq_HELA_Human1.10743847
70ERA_21632823_ChIP-Seq_H3396_Human1.10690574
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09188641
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08853945
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.08853945
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08781898
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.08304709
76TAF2_19829295_ChIP-Seq_ESCs_Human1.07701692
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06262986
78E2F1_20622854_ChIP-Seq_HELA_Human1.05022760
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02759022
80ERG_20517297_ChIP-Seq_VCAP_Human1.02423613
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02397334
82IGF1R_20145208_ChIP-Seq_DFB_Human1.01777878
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00934651
84PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00217381
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99790872
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99165803
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98803706
88ELK1_19687146_ChIP-ChIP_HELA_Human0.98237623
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98030021
90MYC_18555785_ChIP-Seq_MESCs_Mouse0.97653656
91MYC_19829295_ChIP-Seq_ESCs_Human0.97225603
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.96263459
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93949846
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91644787
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90696994
96P53_21459846_ChIP-Seq_SAOS-2_Human0.90642900
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90131858
98STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89796556
99HTT_18923047_ChIP-ChIP_STHdh_Human0.87142432
100NCOR_22424771_ChIP-Seq_293T_Human0.86818962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.89644093
2MP0005645_abnormal_hypothalamus_physiol3.74909612
3MP0009278_abnormal_bone_marrow3.20336862
4MP0005646_abnormal_pituitary_gland3.16481125
5MP0000372_irregular_coat_pigmentation2.71040358
6MP0005397_hematopoietic_system_phenotyp2.70337887
7MP0001545_abnormal_hematopoietic_system2.70337887
8MP0005075_abnormal_melanosome_morpholog2.56800401
9MP0001835_abnormal_antigen_presentation2.25426693
10MP0003195_calcinosis2.24839772
11MP0000569_abnormal_digit_pigmentation2.13177581
12MP0000465_gastrointestinal_hemorrhage2.06882799
13MP0005464_abnormal_platelet_physiology1.93175048
14MP0006036_abnormal_mitochondrial_physio1.91232070
15MP0003191_abnormal_cellular_cholesterol1.88316576
16MP0000516_abnormal_urinary_system1.81587263
17MP0005367_renal/urinary_system_phenotyp1.81587263
18MP0008877_abnormal_DNA_methylation1.72381087
19MP0005671_abnormal_response_to1.68567115
20MP0002148_abnormal_hypersensitivity_rea1.64729865
21MP0003950_abnormal_plasma_membrane1.64658780
22MP0003787_abnormal_imprinting1.59477793
23MP0001968_abnormal_touch/_nociception1.59322474
24MP0008875_abnormal_xenobiotic_pharmacok1.58885683
25MP0003763_abnormal_thymus_physiology1.57858544
26MP0003866_abnormal_defecation1.55806107
27MP0004147_increased_porphyrin_level1.54022552
28MP0002837_dystrophic_cardiac_calcinosis1.53097905
29MP0010386_abnormal_urinary_bladder1.52319070
30MP0003718_maternal_effect1.51358931
31MP0002102_abnormal_ear_morphology1.51203161
32MP0009697_abnormal_copulation1.49801996
33MP0005174_abnormal_tail_pigmentation1.49725117
34MP0001905_abnormal_dopamine_level1.48095214
35MP0009840_abnormal_foam_cell1.46461707
36MP0005084_abnormal_gallbladder_morpholo1.46365551
37MP0008872_abnormal_physiological_respon1.44869420
38MP0003303_peritoneal_inflammation1.42273800
39MP0005000_abnormal_immune_tolerance1.37820599
40MP0002876_abnormal_thyroid_physiology1.37217781
41MP0006292_abnormal_olfactory_placode1.36031757
42MP0003724_increased_susceptibility_to1.31567828
43MP0002163_abnormal_gland_morphology1.29612469
44MP0001790_abnormal_immune_system1.29344040
45MP0005387_immune_system_phenotype1.29344040
46MP0002132_abnormal_respiratory_system1.27317479
47MP0000685_abnormal_immune_system1.22296955
48MP0002234_abnormal_pharynx_morphology1.21328711
49MP0002138_abnormal_hepatobiliary_system1.21167796
50MP0009333_abnormal_splenocyte_physiolog1.20115223
51MP0001764_abnormal_homeostasis1.19778915
52MP0001986_abnormal_taste_sensitivity1.19305567
53MP0001800_abnormal_humoral_immune1.18629148
54MP0002653_abnormal_ependyma_morphology1.17988798
55MP0009785_altered_susceptibility_to1.17478170
56MP0005332_abnormal_amino_acid1.16172609
57MP0003186_abnormal_redox_activity1.16098121
58MP0002693_abnormal_pancreas_physiology1.13514972
59MP0009643_abnormal_urine_homeostasis1.11005185
60MP0002723_abnormal_immune_serum1.10405184
61MP0002420_abnormal_adaptive_immunity1.10211373
62MP0001873_stomach_inflammation1.10146931
63MP0005025_abnormal_response_to1.10060331
64MP0000013_abnormal_adipose_tissue1.09544399
65MP0005379_endocrine/exocrine_gland_phen1.09497855
66MP0001819_abnormal_immune_cell1.07798813
67MP0000015_abnormal_ear_pigmentation1.07466020
68MP0000689_abnormal_spleen_morphology1.06348634
69MP0002452_abnormal_antigen_presenting1.05884006
70MP0005636_abnormal_mineral_homeostasis1.04772292
71MP0003786_premature_aging1.04434930
72MP0008058_abnormal_DNA_repair1.04384171
73MP0006072_abnormal_retinal_apoptosis1.03110436
74MP0002398_abnormal_bone_marrow1.02382819
75MP0004043_abnormal_pH_regulation0.99845750
76MP0000716_abnormal_immune_system0.99592674
77MP0003075_altered_response_to0.98973781
78MP0001664_abnormal_digestion0.98015744
79MP0005410_abnormal_fertilization0.94941566
80MP0001853_heart_inflammation0.92929047
81MP0001881_abnormal_mammary_gland0.92414108
82MP0006035_abnormal_mitochondrial_morpho0.90903939
83MP0002396_abnormal_hematopoietic_system0.89340130
84MP0002095_abnormal_skin_pigmentation0.88633062
85MP0005360_urolithiasis0.88510607
86MP0002429_abnormal_blood_cell0.86700509
87MP0000230_abnormal_systemic_arterial0.86409946
88MP0006276_abnormal_autonomic_nervous0.85426583
89MP0002722_abnormal_immune_system0.84307114
90MP0001845_abnormal_inflammatory_respons0.83182468
91MP0002638_abnormal_pupillary_reflex0.82714196
92MP0004885_abnormal_endolymph0.82475096
93MP0008469_abnormal_protein_level0.81679218
94MP0003172_abnormal_lysosome_physiology0.80283254
95MP0005165_increased_susceptibility_to0.79251163
96MP0002405_respiratory_system_inflammati0.78547555
97MP0005266_abnormal_metabolism0.77206499
98MP0005220_abnormal_exocrine_pancreas0.75114387
99MP0002822_catalepsy0.75013793
100MP0004145_abnormal_muscle_electrophysio0.73386752

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.28678223
2Microvesicular hepatic steatosis (HP:0001414)3.99414029
3Acute necrotizing encephalopathy (HP:0006965)3.96660948
4Mitochondrial inheritance (HP:0001427)3.94468983
5Abnormal mitochondria in muscle tissue (HP:0008316)3.93837162
6Acute encephalopathy (HP:0006846)3.65509076
7Progressive macrocephaly (HP:0004481)3.48473568
8Type 2 muscle fiber atrophy (HP:0003554)3.48123129
9Aplastic anemia (HP:0001915)3.43373035
10Increased CSF lactate (HP:0002490)3.40827206
11Hepatocellular necrosis (HP:0001404)3.34774604
123-Methylglutaconic aciduria (HP:0003535)3.34187689
13Dicarboxylic aciduria (HP:0003215)3.33122009
14Abnormality of dicarboxylic acid metabolism (HP:0010995)3.33122009
15Lipid accumulation in hepatocytes (HP:0006561)3.26641903
16Hepatic necrosis (HP:0002605)3.23497394
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21408655
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21408655
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.06954634
20Cerebral edema (HP:0002181)3.01386369
21Muscle fiber atrophy (HP:0100295)2.97425169
22Ketoacidosis (HP:0001993)2.95292850
23Elevated erythrocyte sedimentation rate (HP:0003565)2.94720450
24Increased muscle lipid content (HP:0009058)2.94348883
25Increased hepatocellular lipid droplets (HP:0006565)2.84914774
26Increased intramyocellular lipid droplets (HP:0012240)2.80140804
27Abnormal rod and cone electroretinograms (HP:0008323)2.72435183
28Severe combined immunodeficiency (HP:0004430)2.71570958
29Type I transferrin isoform profile (HP:0003642)2.69144271
30Hyperglycinemia (HP:0002154)2.65285770
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.64617326
32Abnormal pupillary function (HP:0007686)2.61919801
33Ketosis (HP:0001946)2.60457134
34Hyperthyroidism (HP:0000836)2.58303689
35Agammaglobulinemia (HP:0004432)2.56743283
36Lactic acidosis (HP:0003128)2.56392567
37Thyroiditis (HP:0100646)2.53865910
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49217715
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.48996053
40Abnormal protein N-linked glycosylation (HP:0012347)2.48996053
41Abnormal protein glycosylation (HP:0012346)2.48996053
42Abnormal glycosylation (HP:0012345)2.48996053
43Congenital stationary night blindness (HP:0007642)2.46042380
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39286860
45Hypoglycemic seizures (HP:0002173)2.38258934
46Lethargy (HP:0001254)2.37537308
47Optic disc pallor (HP:0000543)2.37171668
48Abnormality of transition element cation homeostasis (HP:0011030)2.36167398
49Abnormality of B cell number (HP:0010975)2.28647659
50Abnormality of the renal cortex (HP:0011035)2.26695517
51Attenuation of retinal blood vessels (HP:0007843)2.26237850
52Exercise intolerance (HP:0003546)2.21687488
53Abnormality of iron homeostasis (HP:0011031)2.19177869
54Renal Fanconi syndrome (HP:0001994)2.16949095
55Exertional dyspnea (HP:0002875)2.13349598
56Molar tooth sign on MRI (HP:0002419)2.13090465
57Abnormality of midbrain morphology (HP:0002418)2.13090465
58Brushfield spots (HP:0001088)2.10798293
59Cerebral palsy (HP:0100021)2.10717106
60Increased serum ferritin (HP:0003281)2.08808061
61Petechiae (HP:0000967)2.08223500
62Hypoproteinemia (HP:0003075)2.08162907
63Thrombocytosis (HP:0001894)2.06268050
64Methylmalonic aciduria (HP:0012120)2.04859786
65Respiratory failure (HP:0002878)2.04168599
66Calf muscle hypertrophy (HP:0008981)2.03890007
67Exercise-induced myalgia (HP:0003738)2.02705436
68Decreased central vision (HP:0007663)2.02106778
69Opisthotonus (HP:0002179)2.00628006
70Increased serum lactate (HP:0002151)2.00088734
71Chronic obstructive pulmonary disease (HP:0006510)1.98626532
72Obstructive lung disease (HP:0006536)1.98626532
73Autoimmune hemolytic anemia (HP:0001890)1.97528180
74Abnormality of the prostate (HP:0008775)1.96792360
75Renal cortical cysts (HP:0000803)1.91765076
76Severe visual impairment (HP:0001141)1.91553265
77Pancreatic cysts (HP:0001737)1.90886698
78Abolished electroretinogram (ERG) (HP:0000550)1.88963157
79Abnormal number of erythroid precursors (HP:0012131)1.88427732
80Bile duct proliferation (HP:0001408)1.88154308
81Abnormal biliary tract physiology (HP:0012439)1.88154308
82Episodic fever (HP:0001954)1.87781497
83Palpitations (HP:0001962)1.87123012
84Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86671641
85Leukocytosis (HP:0001974)1.86137674
86Anhidrosis (HP:0000970)1.84811813
87Hyperglycinuria (HP:0003108)1.82629873
88Recurrent fungal infections (HP:0002841)1.82240994
89Aplasia/Hypoplasia of the thymus (HP:0010515)1.81676033
90Combined immunodeficiency (HP:0005387)1.81544095
91Abnormality of DNA repair (HP:0003254)1.80786234
92B lymphocytopenia (HP:0010976)1.80190488
93Muscle hypertrophy of the lower extremities (HP:0008968)1.78699490
94Fatigable weakness (HP:0003473)1.78416161
95Abnormality of the neuromuscular junction (HP:0003398)1.78416161
96Pancytopenia (HP:0001876)1.76143224
97Abnormality of dental color (HP:0011073)1.76109539
98Hypertensive crisis (HP:0100735)1.74955113
99Progressive microcephaly (HP:0000253)1.74675567
100Asymmetric septal hypertrophy (HP:0001670)1.74606578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.12578361
2MUSK3.26401545
3VRK23.10091251
4MAP4K22.94861802
5KDR2.88877561
6TAOK32.68538542
7SCYL22.58636798
8MAP3K112.54527797
9TESK22.39483588
10MAPKAPK32.30348616
11FES2.28453031
12PIK3CG2.20766610
13FRK2.19164555
14KIT2.18098430
15TXK2.09716084
16NME22.08806173
17NUAK12.04449141
18PBK1.96624641
19DAPK11.87806279
20PINK11.73853997
21DAPK21.71100784
22MAP4K11.69491868
23MATK1.66177294
24EIF2AK11.37465259
25MAPKAPK51.29075764
26TEC1.25706999
27IKBKB1.24972565
28CDK191.23678151
29PASK1.18892883
30NME11.18492800
31ADRBK21.16829171
32FLT31.11897802
33VRK11.07199227
34BMPR21.07137592
35SYK1.06691819
36TIE11.05260013
37TESK11.02992653
38TBK11.01357242
39JAK30.98265635
40GRK10.97024833
41RPS6KB20.97017895
42PIM20.93945820
43TAOK20.92444488
44PTK2B0.92277942
45CCNB10.91640756
46INSRR0.89056435
47OXSR10.86322703
48EIF2AK30.84071788
49MAP3K120.82339854
50GRK60.82327481
51PRKCQ0.81605369
52ITK0.79022324
53TNK20.77375662
54PHKG10.75577202
55PHKG20.75577202
56ABL20.72641030
57TAOK10.71985043
58BTK0.69975489
59CSNK1G30.68698262
60LCK0.67853769
61CDK80.66100716
62LYN0.65371841
63IKBKE0.63076406
64MST40.60565069
65CAMKK20.59147574
66CSF1R0.58714896
67ADRBK10.55903527
68CSNK1G20.53660263
69ATR0.52453837
70GRK50.52405922
71BMPR1B0.51756603
72MAPK110.51509782
73ZAK0.51452763
74DAPK30.48632183
75IGF1R0.46932636
76WNK40.46414937
77LIMK10.45031744
78TAF10.44942386
79STK390.43912045
80MAP3K30.43229502
81RPS6KA50.41072816
82MAP2K60.40725020
83CSNK1G10.40500693
84OBSCN0.39984268
85PRKCA0.39947352
86ERN10.36702725
87GRK70.36635916
88MAP2K30.36431760
89FER0.35570717
90MAP3K10.35251897
91ABL10.35129920
92CDK90.35128233
93CSK0.33080834
94PRKG20.33001540
95PIK3CA0.32599214
96PRKACB0.32511841
97HCK0.32492031
98WNK30.31714537
99RPS6KA60.31067498
100EIF2AK20.30656640

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.87358966
2Proteasome_Homo sapiens_hsa030502.81343266
3Primary immunodeficiency_Homo sapiens_hsa053402.71442005
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.63823938
5Type I diabetes mellitus_Homo sapiens_hsa049402.45692347
6Parkinsons disease_Homo sapiens_hsa050122.35215148
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31051630
8Ribosome_Homo sapiens_hsa030102.30189470
9Peroxisome_Homo sapiens_hsa041462.24683521
10Graft-versus-host disease_Homo sapiens_hsa053322.23748362
11Fatty acid elongation_Homo sapiens_hsa000622.23448742
12Autoimmune thyroid disease_Homo sapiens_hsa053202.18716566
13Allograft rejection_Homo sapiens_hsa053302.18355274
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11878001
15Asthma_Homo sapiens_hsa053102.08228929
16Base excision repair_Homo sapiens_hsa034101.94114572
17RNA polymerase_Homo sapiens_hsa030201.80218386
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79630846
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78213489
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.73642685
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.60757793
22Nitrogen metabolism_Homo sapiens_hsa009101.58924481
23Butanoate metabolism_Homo sapiens_hsa006501.53350993
24Linoleic acid metabolism_Homo sapiens_hsa005911.49275747
25Regulation of autophagy_Homo sapiens_hsa041401.48806508
26One carbon pool by folate_Homo sapiens_hsa006701.42389692
27Protein export_Homo sapiens_hsa030601.42076393
28Arachidonic acid metabolism_Homo sapiens_hsa005901.37840116
29Antigen processing and presentation_Homo sapiens_hsa046121.37376972
30Pyrimidine metabolism_Homo sapiens_hsa002401.37078273
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36221960
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32414939
33DNA replication_Homo sapiens_hsa030301.29267802
34Sulfur metabolism_Homo sapiens_hsa009201.28229864
35Alzheimers disease_Homo sapiens_hsa050101.25452509
36Phototransduction_Homo sapiens_hsa047441.22643102
37Huntingtons disease_Homo sapiens_hsa050161.18222995
38Nucleotide excision repair_Homo sapiens_hsa034201.14323253
39Non-homologous end-joining_Homo sapiens_hsa034501.12877374
40Chemical carcinogenesis_Homo sapiens_hsa052041.11521120
41Purine metabolism_Homo sapiens_hsa002301.11144016
42Rheumatoid arthritis_Homo sapiens_hsa053231.10282385
43RNA degradation_Homo sapiens_hsa030181.10181842
44Hematopoietic cell lineage_Homo sapiens_hsa046401.06766282
45Tryptophan metabolism_Homo sapiens_hsa003801.05402985
46Selenocompound metabolism_Homo sapiens_hsa004501.05259497
47Glutathione metabolism_Homo sapiens_hsa004801.04453781
48Ether lipid metabolism_Homo sapiens_hsa005651.04332923
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01522613
50Caffeine metabolism_Homo sapiens_hsa002320.99711346
51Fatty acid degradation_Homo sapiens_hsa000710.99561205
52Propanoate metabolism_Homo sapiens_hsa006400.98752593
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98180356
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97632201
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96774722
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.95876828
57Fatty acid metabolism_Homo sapiens_hsa012120.95001901
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94124620
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92687269
60Collecting duct acid secretion_Homo sapiens_hsa049660.89408194
61Folate biosynthesis_Homo sapiens_hsa007900.89131428
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87002189
63Mismatch repair_Homo sapiens_hsa034300.85784094
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.85178279
65Homologous recombination_Homo sapiens_hsa034400.81543209
66Fanconi anemia pathway_Homo sapiens_hsa034600.80789425
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80281974
68Cardiac muscle contraction_Homo sapiens_hsa042600.77471270
69Metabolic pathways_Homo sapiens_hsa011000.75230572
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73287656
71beta-Alanine metabolism_Homo sapiens_hsa004100.70205856
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68043525
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67879786
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67718969
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.67229665
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.67133556
77Viral myocarditis_Homo sapiens_hsa054160.63493551
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63275916
79Pyruvate metabolism_Homo sapiens_hsa006200.62596124
80N-Glycan biosynthesis_Homo sapiens_hsa005100.61519414
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.56826865
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54554524
83Sulfur relay system_Homo sapiens_hsa041220.50954567
84Systemic lupus erythematosus_Homo sapiens_hsa053220.50776829
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.50397005
86Ovarian steroidogenesis_Homo sapiens_hsa049130.48387593
87Pentose phosphate pathway_Homo sapiens_hsa000300.48192517
88Retinol metabolism_Homo sapiens_hsa008300.48186651
89Staphylococcus aureus infection_Homo sapiens_hsa051500.48015962
90Herpes simplex infection_Homo sapiens_hsa051680.44618965
91Platelet activation_Homo sapiens_hsa046110.43856378
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42890493
93Pancreatic secretion_Homo sapiens_hsa049720.40643178
94Basal transcription factors_Homo sapiens_hsa030220.34552500
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33908156
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33413305
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33263662
98Carbon metabolism_Homo sapiens_hsa012000.31946002
99Glycerolipid metabolism_Homo sapiens_hsa005610.30511010
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29982055

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