KRT18P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA endoreduplication (GO:0032875)4.80375167
2DNA strand elongation involved in DNA replication (GO:0006271)4.80128664
3DNA strand elongation (GO:0022616)4.56077030
4nuclear pore complex assembly (GO:0051292)4.46308374
5DNA ligation (GO:0006266)4.41730463
6proteasome assembly (GO:0043248)4.38249043
7DNA unwinding involved in DNA replication (GO:0006268)4.36808731
8DNA topological change (GO:0006265)4.30522735
9DNA replication initiation (GO:0006270)4.27374939
10kinetochore organization (GO:0051383)4.17331719
11kinetochore assembly (GO:0051382)4.15676111
12telomere maintenance via semi-conservative replication (GO:0032201)4.15300573
13nuclear pore organization (GO:0006999)4.05142402
14CENP-A containing nucleosome assembly (GO:0034080)4.04240278
15regulation of mitochondrial translation (GO:0070129)4.01306191
16DNA replication checkpoint (GO:0000076)4.00992302
17chromatin remodeling at centromere (GO:0031055)3.95514450
18nucleotide-excision repair, DNA gap filling (GO:0006297)3.93548706
19viral mRNA export from host cell nucleus (GO:0046784)3.92147263
20replication fork processing (GO:0031297)3.89589838
21protein-cofactor linkage (GO:0018065)3.87979758
22ribosome biogenesis (GO:0042254)3.84971388
23chaperone-mediated protein transport (GO:0072321)3.84375428
24DNA strand renaturation (GO:0000733)3.82156289
25respiratory chain complex IV assembly (GO:0008535)3.77708648
26maturation of SSU-rRNA (GO:0030490)3.76986674
27pore complex assembly (GO:0046931)3.63786493
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.63342445
29mitotic metaphase plate congression (GO:0007080)3.60698596
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58542204
31telomere maintenance via recombination (GO:0000722)3.57616865
32termination of RNA polymerase I transcription (GO:0006363)3.55575436
33protein localization to kinetochore (GO:0034501)3.48966022
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.44965607
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44871891
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44340308
37mitotic recombination (GO:0006312)3.41886881
38ribosomal small subunit assembly (GO:0000028)3.39643415
39metaphase plate congression (GO:0051310)3.37898463
40ribonucleoprotein complex biogenesis (GO:0022613)3.37228216
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36148310
42microtubule depolymerization (GO:0007019)3.32109545
43cellular component biogenesis (GO:0044085)3.31219457
44translational termination (GO:0006415)3.30969646
45regulation of oxidative stress-induced neuron death (GO:1903203)3.30009068
46cytochrome complex assembly (GO:0017004)3.28956915
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.28905419
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28905419
49protein complex biogenesis (GO:0070271)3.27306248
50positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27110211
51DNA replication-independent nucleosome organization (GO:0034724)3.26914172
52DNA replication-independent nucleosome assembly (GO:0006336)3.26914172
53transcription initiation from RNA polymerase I promoter (GO:0006361)3.26633233
54granulocyte differentiation (GO:0030851)3.26551206
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25489224
56signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25489224
57signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25489224
58mitochondrial respiratory chain complex assembly (GO:0033108)3.25037495
59inner mitochondrial membrane organization (GO:0007007)3.23773234
60histone exchange (GO:0043486)3.22787968
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22080319
62negative regulation of ligase activity (GO:0051352)3.22080319
63viral transcription (GO:0019083)3.20861562
64mitotic nuclear envelope disassembly (GO:0007077)3.18573141
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16845313
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16845313
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16469304
68spindle checkpoint (GO:0031577)3.14403353
69signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12623968
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.12623968
71GMP metabolic process (GO:0046037)3.12435562
72positive regulation of ligase activity (GO:0051351)3.09062955
73maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08184447
74sister chromatid cohesion (GO:0007062)3.07906909
75transcription from RNA polymerase I promoter (GO:0006360)3.07378596
76signal transduction involved in cell cycle checkpoint (GO:0072395)3.06349462
77ATP synthesis coupled proton transport (GO:0015986)3.02269531
78energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02269531
79ribosomal small subunit biogenesis (GO:0042274)2.97340083
80sister chromatid segregation (GO:0000819)2.94679327
81mitochondrial respiratory chain complex I assembly (GO:0032981)2.94180159
82NADH dehydrogenase complex assembly (GO:0010257)2.94180159
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94180159
84regulation of nucleobase-containing compound transport (GO:0032239)2.93066516
85telomere maintenance via telomere lengthening (GO:0010833)2.92675733
86mitotic spindle assembly checkpoint (GO:0007094)2.92010365
87negative regulation of chromosome segregation (GO:0051985)2.91274312
88SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91099560
89spindle assembly checkpoint (GO:0071173)2.90383518
90regulation of nuclear cell cycle DNA replication (GO:0033262)2.88661368
91oxidative phosphorylation (GO:0006119)2.88491396
92resolution of meiotic recombination intermediates (GO:0000712)2.88470222
93negative regulation of mitotic sister chromatid separation (GO:2000816)2.87760287
94negative regulation of sister chromatid segregation (GO:0033046)2.87760287
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87760287
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87760287
97negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87760287
98regulation of ubiquitin-protein transferase activity (GO:0051438)2.87037379
99synapsis (GO:0007129)2.86934745
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86235684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.15482456
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.34256347
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.09391522
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.00457927
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.85287444
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.74974913
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.53538016
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.49304214
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.46338953
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.30702082
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13456800
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.88784631
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85830837
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70053874
15ELK1_19687146_ChIP-ChIP_HELA_Human2.63008401
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60106792
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59790051
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50122428
19DCP1A_22483619_ChIP-Seq_HELA_Human2.49914100
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40522824
21YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35186006
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33598794
23CIITA_25753668_ChIP-Seq_RAJI_Human2.27890137
24GABP_19822575_ChIP-Seq_HepG2_Human2.27167997
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26256324
26FOXP3_21729870_ChIP-Seq_TREG_Human2.25376903
27XRN2_22483619_ChIP-Seq_HELA_Human2.25103096
28VDR_23849224_ChIP-Seq_CD4+_Human2.19816429
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14704355
30TTF2_22483619_ChIP-Seq_HELA_Human2.14316242
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.10342356
32E2F1_21310950_ChIP-Seq_MCF-7_Human2.04236319
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.99848396
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99001048
35KDM5A_27292631_Chip-Seq_BREAST_Human1.94718362
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93944586
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86052904
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.81769488
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80409711
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77571411
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70863607
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64281295
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.62956062
44AR_21909140_ChIP-Seq_LNCAP_Human1.56256551
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55779338
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55715591
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52378035
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50718032
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49545430
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48326095
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.47746262
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42548832
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42357208
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33762200
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26256556
56E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24279358
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21348374
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20758373
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20529725
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20237104
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18176875
62NCOR1_26117541_ChIP-Seq_K562_Human1.16185177
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15395992
64MYC_18940864_ChIP-ChIP_HL60_Human1.13744688
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10075514
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09616279
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.09420222
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07544662
69CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05009867
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04477587
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04470152
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01984877
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00894129
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98183727
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96738823
76TFEB_21752829_ChIP-Seq_HELA_Human0.95769214
77TP63_19390658_ChIP-ChIP_HaCaT_Human0.94289802
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93046748
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90378925
80GATA4_21415370_ChIP-Seq_HL-1_Mouse0.90052926
81NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88811025
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88385548
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88010265
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87478155
85SPI1_23547873_ChIP-Seq_NB4_Human0.85147382
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84793763
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84301534
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83404999
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.81694635
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80242458
91TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76131664
92ELF5_23300383_ChIP-Seq_T47D_Human0.75166865
93CHD1_26751641_Chip-Seq_LNCaP_Human0.71761192
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70415554
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.66306222
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.66070657
97GATA1_19941826_ChIP-Seq_K562_Human0.63763219
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.63664586
99GATA1_22025678_ChIP-Seq_K562_Human0.63635283
100SOX2_18555785_ChIP-Seq_MESCs_Mouse0.61847989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.31920821
2MP0008058_abnormal_DNA_repair4.27859270
3MP0010094_abnormal_chromosome_stability4.25328347
4MP0003111_abnormal_nucleus_morphology3.55496775
5MP0009697_abnormal_copulation3.18681774
6MP0004957_abnormal_blastocyst_morpholog2.98653437
7MP0006035_abnormal_mitochondrial_morpho2.87685622
8MP0003646_muscle_fatigue2.71314873
9MP0008057_abnormal_DNA_replication2.70891029
10MP0003077_abnormal_cell_cycle2.48986001
11MP0001661_extended_life_span2.45704348
12MP0006054_spinal_hemorrhage2.43495755
13MP0003950_abnormal_plasma_membrane2.37339112
14MP0008932_abnormal_embryonic_tissue2.29772550
15MP0003806_abnormal_nucleotide_metabolis2.25554039
16MP0002132_abnormal_respiratory_system2.20412284
17MP0003186_abnormal_redox_activity2.11236495
18MP0000358_abnormal_cell_content/2.08758966
19MP0003136_yellow_coat_color2.07960388
20MP0002396_abnormal_hematopoietic_system2.03418430
21MP0008995_early_reproductive_senescence1.93037298
22MP0003786_premature_aging1.86290972
23MP0004185_abnormal_adipocyte_glucose1.83655615
24MP0008007_abnormal_cellular_replicative1.83333149
25MP0004808_abnormal_hematopoietic_stem1.81062002
26MP0006036_abnormal_mitochondrial_physio1.77606615
27MP0002160_abnormal_reproductive_system1.71661669
28MP0003718_maternal_effect1.61648296
29MP0004147_increased_porphyrin_level1.56286604
30MP0003195_calcinosis1.50059233
31MP0005380_embryogenesis_phenotype1.49390499
32MP0001672_abnormal_embryogenesis/_devel1.49390499
33MP0001697_abnormal_embryo_size1.48794496
34MP0003984_embryonic_growth_retardation1.47743654
35MP0000313_abnormal_cell_death1.45260319
36MP0002088_abnormal_embryonic_growth/wei1.44923628
37MP0008260_abnormal_autophagy1.44829290
38MP0000569_abnormal_digit_pigmentation1.41958491
39MP0002210_abnormal_sex_determination1.41475422
40MP0002269_muscular_atrophy1.40467831
41MP0001243_abnormal_dermal_layer1.35109957
42MP0001929_abnormal_gametogenesis1.34226164
43MP0000350_abnormal_cell_proliferation1.33784366
44MP0000751_myopathy1.32322701
45MP0005408_hypopigmentation1.32233580
46MP0010307_abnormal_tumor_latency1.29282558
47MP0000015_abnormal_ear_pigmentation1.26524517
48MP0002080_prenatal_lethality1.25746025
49MP0001730_embryonic_growth_arrest1.24175055
50MP0006292_abnormal_olfactory_placode1.14521996
51MP0000749_muscle_degeneration1.11959178
52MP0001545_abnormal_hematopoietic_system1.11586692
53MP0005397_hematopoietic_system_phenotyp1.11586692
54MP0002837_dystrophic_cardiac_calcinosis1.09286559
55MP0003959_abnormal_lean_body1.07723952
56MP0002138_abnormal_hepatobiliary_system1.05454917
57MP0004084_abnormal_cardiac_muscle1.04219161
58MP0005501_abnormal_skin_physiology1.03701294
59MP0009379_abnormal_foot_pigmentation1.01105556
60MP0000372_irregular_coat_pigmentation0.97360575
61MP0003698_abnormal_male_reproductive0.97232076
62MP0002938_white_spotting0.96433337
63MP0002019_abnormal_tumor_incidence0.94846759
64MP0002086_abnormal_extraembryonic_tissu0.94096456
65MP0001145_abnormal_male_reproductive0.93515577
66MP0002084_abnormal_developmental_patter0.90438103
67MP0000653_abnormal_sex_gland0.89269440
68MP0003011_delayed_dark_adaptation0.89139071
69MP0002085_abnormal_embryonic_tissue0.88684727
70MP0005058_abnormal_lysosome_morphology0.85901186
71MP0005666_abnormal_adipose_tissue0.85194407
72MP0000747_muscle_weakness0.84326377
73MP0005319_abnormal_enzyme/_coenzyme0.83438830
74MP0005409_darkened_coat_color0.83314199
75MP0005075_abnormal_melanosome_morpholog0.83238142
76MP0005395_other_phenotype0.81830990
77MP0002111_abnormal_tail_morphology0.80866844
78MP0002095_abnormal_skin_pigmentation0.79560299
79MP0005384_cellular_phenotype0.78704686
80MP0001299_abnormal_eye_distance/0.77975509
81MP0005670_abnormal_white_adipose0.77248951
82MP0005389_reproductive_system_phenotype0.76825087
83MP0002653_abnormal_ependyma_morphology0.76590415
84MP0003121_genomic_imprinting0.75734868
85MP0001727_abnormal_embryo_implantation0.74789748
86MP0001881_abnormal_mammary_gland0.74458345
87MP0000371_diluted_coat_color0.73990333
88MP0003890_abnormal_embryonic-extraembry0.73137969
89MP0005083_abnormal_biliary_tract0.72443869
90MP0003699_abnormal_female_reproductive0.71091083
91MP0010630_abnormal_cardiac_muscle0.68432241
92MP0000703_abnormal_thymus_morphology0.68348572
93MP0004197_abnormal_fetal_growth/weight/0.67926775
94MP0002161_abnormal_fertility/fecundity0.66668215
95MP0001915_intracranial_hemorrhage0.65633676
96MP0005174_abnormal_tail_pigmentation0.64757049
97MP0002127_abnormal_cardiovascular_syste0.63022285
98MP0004130_abnormal_muscle_cell0.62383123
99MP0002970_abnormal_white_adipose0.61517777
100MP0002108_abnormal_muscle_morphology0.61089462

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.44120364
2Abnormal number of erythroid precursors (HP:0012131)4.16565438
3Birth length less than 3rd percentile (HP:0003561)4.04396481
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.04025630
5Abnormality of cells of the erythroid lineage (HP:0012130)3.94138941
6Acute necrotizing encephalopathy (HP:0006965)3.79203037
7Chromsome breakage (HP:0040012)3.63021506
8Abnormal mitochondria in muscle tissue (HP:0008316)3.59877493
9Progressive macrocephaly (HP:0004481)3.45966582
10Abnormality of reticulocytes (HP:0004312)3.38513942
11Urethral obstruction (HP:0000796)3.36113970
12Absent thumb (HP:0009777)3.24966419
13Abnormality of DNA repair (HP:0003254)3.15413289
14Mitochondrial inheritance (HP:0001427)3.03486774
15Increased CSF lactate (HP:0002490)2.99605666
16Acute encephalopathy (HP:0006846)2.98051580
17Macrocytic anemia (HP:0001972)2.95631348
18Abnormality of chromosome stability (HP:0003220)2.91056290
19Hepatocellular necrosis (HP:0001404)2.89829947
20Reticulocytosis (HP:0001923)2.88489847
21Short middle phalanx of the 5th finger (HP:0004220)2.88475847
22Pallor (HP:0000980)2.85068140
23Homocystinuria (HP:0002156)2.85025910
24Abnormality of homocysteine metabolism (HP:0010919)2.85025910
25Redundant skin (HP:0001582)2.83509731
26Sensory axonal neuropathy (HP:0003390)2.74824929
27Tinnitus (HP:0000360)2.71653115
28Hypoplasia of the capital femoral epiphysis (HP:0003090)2.71474079
29Small intestinal stenosis (HP:0012848)2.70964578
30Duodenal stenosis (HP:0100867)2.70964578
31Volvulus (HP:0002580)2.68766266
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.66044565
33Ileus (HP:0002595)2.64791741
34Ectopic kidney (HP:0000086)2.63253084
35Pustule (HP:0200039)2.61165959
36Thoracic kyphosis (HP:0002942)2.60379802
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.54730109
38Brushfield spots (HP:0001088)2.51097424
39Meckel diverticulum (HP:0002245)2.49580722
40Acanthocytosis (HP:0001927)2.49431697
41Short 5th finger (HP:0009237)2.46538218
42Microvesicular hepatic steatosis (HP:0001414)2.45862528
43Abnormality of the preputium (HP:0100587)2.45859769
44Cellular immunodeficiency (HP:0005374)2.45393976
45Horseshoe kidney (HP:0000085)2.42920700
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.38775606
47Poikilocytosis (HP:0004447)2.35567395
48Cerebral edema (HP:0002181)2.34114792
49Epiphyseal stippling (HP:0010655)2.33630312
50Delusions (HP:0000746)2.33488326
51Long clavicles (HP:0000890)2.31364435
52Tubulointerstitial nephritis (HP:0001970)2.30821155
53Acute myeloid leukemia (HP:0004808)2.30158530
54Hepatic necrosis (HP:0002605)2.28457801
55Respiratory difficulties (HP:0002880)2.28006540
56Abnormality of the duodenum (HP:0002246)2.27699715
57Orthostatic hypotension (HP:0001278)2.25713975
58Abnormality of the ileum (HP:0001549)2.25500404
59Polycythemia (HP:0001901)2.25444530
60Beaking of vertebral bodies (HP:0004568)2.25278198
61Ependymoma (HP:0002888)2.24349334
62Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.23146146
63Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.23028685
64Absent epiphyses (HP:0010577)2.23028685
65Myelodysplasia (HP:0002863)2.22717740
66Truncus arteriosus (HP:0001660)2.18172145
67Ulnar deviation of the wrist (HP:0003049)2.15681484
68Duplicated collecting system (HP:0000081)2.14437804
69Thyroid-stimulating hormone excess (HP:0002925)2.12782957
70Hyperthyroidism (HP:0000836)2.12701488
71Severe combined immunodeficiency (HP:0004430)2.06930263
72Respiratory failure (HP:0002878)2.05226629
73Hypoplasia of the pons (HP:0012110)2.05182534
74Pancreatic islet-cell hyperplasia (HP:0004510)2.04226982
75Abnormal epiphyseal ossification (HP:0010656)2.03195784
76Combined immunodeficiency (HP:0005387)2.03167057
77Abnormality of the carotid arteries (HP:0005344)2.02053447
78Clubbing of toes (HP:0100760)2.01529940
79Irregular epiphyses (HP:0010582)2.00128177
80Abnormal gallbladder physiology (HP:0012438)1.97298169
81Cholecystitis (HP:0001082)1.97298169
82Type I transferrin isoform profile (HP:0003642)1.96987787
83Abnormal number of incisors (HP:0011064)1.95919905
84CNS demyelination (HP:0007305)1.94387816
85Sloping forehead (HP:0000340)1.92977648
86Cerebral hypomyelination (HP:0006808)1.89791963
87Progressive external ophthalmoplegia (HP:0000590)1.89583823
88Short thumb (HP:0009778)1.89342569
89Exercise intolerance (HP:0003546)1.88561362
90Neutropenia (HP:0001875)1.88163267
91Abnormality of pyrimidine metabolism (HP:0004353)1.87302121
92Pulmonary artery stenosis (HP:0004415)1.85688776
93Abnormality of the renal collecting system (HP:0004742)1.85210140
94Short chin (HP:0000331)1.84366844
95Hypoparathyroidism (HP:0000829)1.84311361
96Abnormality of dental color (HP:0011073)1.84139393
97Leukodystrophy (HP:0002415)1.83975713
98Hypoplastic iliac wings (HP:0002866)1.83564283
99Hyperinsulinemic hypoglycemia (HP:0000825)1.78369700
100Hypertensive crisis (HP:0100735)1.77431841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.28701542
2PDK23.97123384
3PBK3.51182164
4EIF2AK13.19277824
5ZAK2.87192204
6MAPKAPK32.86553603
7TTK2.85577284
8MST42.71394694
9FRK2.58379407
10STK42.34731824
11STK102.28945463
12CDC72.24632100
13BUB12.17659395
14STK162.10737851
15PLK22.09766718
16PLK42.03802665
17VRK21.97332575
18PRKCI1.93328173
19NME11.84098787
20RIPK11.77486407
21PLK31.65931751
22CDK81.62752897
23MAP4K21.57345942
24CHEK21.57345718
25FLT31.54563713
26BRSK11.53034266
27PLK11.47674557
28NEK21.47264678
29BRSK21.41150430
30RAF11.36702727
31WEE11.32085999
32CDK121.30833423
33NEK11.30398014
34SRPK11.26921947
35ATR1.25149644
36TAF11.22849897
37RIPK41.20805156
38AURKB1.20571791
39KIT1.17104327
40CCNB11.16462434
41CLK11.11599244
42RPS6KB21.05880538
43EIF2AK21.03924299
44MAP3K81.03628233
45LRRK21.03275004
46RPS6KA40.86121263
47TRPM70.80206322
48TAOK10.79375271
49CDK70.78159746
50OXSR10.76002110
51NUAK10.74630505
52CSNK2A20.74008932
53NLK0.72889510
54CHEK10.72450248
55ATM0.72311271
56WNK40.67556350
57ALK0.67280939
58TYRO30.66967554
59MAP3K100.66664333
60DAPK10.61481595
61CDK20.60531263
62CAMK1G0.60509154
63PIM20.57603449
64CSNK1E0.57068471
65KSR20.56820923
66TNIK0.56577999
67SCYL20.55916642
68CAMK1D0.55589443
69DYRK20.54736990
70VRK10.54292636
71MARK30.53401956
72STK380.52992327
73BRAF0.52230504
74EEF2K0.51199315
75BRD40.50367594
76CSNK2A10.50209566
77PAK10.48844354
78CSNK1G30.44374754
79IRAK30.43763874
80CDK10.43299032
81PTK2B0.42194978
82CAMK10.41799661
83PAK40.39289924
84MAP3K70.38755773
85AKT30.37686180
86ERBB20.35936243
87CDK40.35843803
88NEK60.35184786
89SGK10.32486204
90AKT20.27959607
91CASK0.27940159
92STK110.24637625
93ADRBK10.24312298
94PHKG10.23089257
95PHKG20.23089257
96PAK20.21625563
97ARAF0.21622950
98PRKG20.21141325
99FGFR20.20571971
100CAMK40.18105573

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.46989851
2Proteasome_Homo sapiens_hsa030504.28980330
3Mismatch repair_Homo sapiens_hsa034304.14003281
4Ribosome_Homo sapiens_hsa030103.37445825
5Non-homologous end-joining_Homo sapiens_hsa034503.31327949
6Homologous recombination_Homo sapiens_hsa034402.90248743
7Oxidative phosphorylation_Homo sapiens_hsa001902.72039297
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71411622
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71084690
10Nucleotide excision repair_Homo sapiens_hsa034202.62778575
11Parkinsons disease_Homo sapiens_hsa050122.54100690
12One carbon pool by folate_Homo sapiens_hsa006702.48990177
13Spliceosome_Homo sapiens_hsa030402.29737623
14RNA transport_Homo sapiens_hsa030132.28846185
15Base excision repair_Homo sapiens_hsa034102.24955436
16Fanconi anemia pathway_Homo sapiens_hsa034602.24139057
17RNA polymerase_Homo sapiens_hsa030202.13309627
18Cell cycle_Homo sapiens_hsa041102.10950383
19Basal transcription factors_Homo sapiens_hsa030222.09676989
20Huntingtons disease_Homo sapiens_hsa050161.97679177
21Protein export_Homo sapiens_hsa030601.72899693
22Folate biosynthesis_Homo sapiens_hsa007901.64756219
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61114645
24Pyrimidine metabolism_Homo sapiens_hsa002401.54061456
25Alzheimers disease_Homo sapiens_hsa050101.42743912
26RNA degradation_Homo sapiens_hsa030181.37151006
27p53 signaling pathway_Homo sapiens_hsa041151.29433077
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28388279
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27317763
30mRNA surveillance pathway_Homo sapiens_hsa030151.24413666
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23544108
32Vitamin B6 metabolism_Homo sapiens_hsa007501.20949885
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.19023466
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16046430
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12418687
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11462209
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06299981
38Purine metabolism_Homo sapiens_hsa002301.02382851
39Glutathione metabolism_Homo sapiens_hsa004800.99020708
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90131629
41Pyruvate metabolism_Homo sapiens_hsa006200.90014067
42Acute myeloid leukemia_Homo sapiens_hsa052210.87878540
43Selenocompound metabolism_Homo sapiens_hsa004500.86553055
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85300343
45Oocyte meiosis_Homo sapiens_hsa041140.78807134
46Fructose and mannose metabolism_Homo sapiens_hsa000510.77680308
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75325361
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74534401
49Lysine degradation_Homo sapiens_hsa003100.71098011
50Cardiac muscle contraction_Homo sapiens_hsa042600.69472671
51N-Glycan biosynthesis_Homo sapiens_hsa005100.68697605
52Thyroid cancer_Homo sapiens_hsa052160.66585185
53Biosynthesis of amino acids_Homo sapiens_hsa012300.62232831
54Collecting duct acid secretion_Homo sapiens_hsa049660.59354491
55Vitamin digestion and absorption_Homo sapiens_hsa049770.57099402
56Carbon metabolism_Homo sapiens_hsa012000.57025988
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55422048
58Metabolic pathways_Homo sapiens_hsa011000.52731743
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51429300
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.49901668
61Epstein-Barr virus infection_Homo sapiens_hsa051690.49414260
62Peroxisome_Homo sapiens_hsa041460.46321786
63Sulfur relay system_Homo sapiens_hsa041220.44420238
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41597250
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41534266
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41486285
67Viral carcinogenesis_Homo sapiens_hsa052030.37809357
68Steroid biosynthesis_Homo sapiens_hsa001000.37134949
69Melanoma_Homo sapiens_hsa052180.36595136
70Fatty acid elongation_Homo sapiens_hsa000620.35136809
71HIF-1 signaling pathway_Homo sapiens_hsa040660.33428230
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31259941
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29813617
74Regulation of autophagy_Homo sapiens_hsa041400.27641842
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27413225
76mTOR signaling pathway_Homo sapiens_hsa041500.26231962
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26214993
78Pancreatic cancer_Homo sapiens_hsa052120.25332932
79Phototransduction_Homo sapiens_hsa047440.25222170
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25189272
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.25106333
82Glycerolipid metabolism_Homo sapiens_hsa005610.22976859
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22308895
84HTLV-I infection_Homo sapiens_hsa051660.21077578
85Prostate cancer_Homo sapiens_hsa052150.19640788
86Other glycan degradation_Homo sapiens_hsa005110.19157084
87Type II diabetes mellitus_Homo sapiens_hsa049300.18645266
88Insulin signaling pathway_Homo sapiens_hsa049100.17961059
89MicroRNAs in cancer_Homo sapiens_hsa052060.16567511
90Notch signaling pathway_Homo sapiens_hsa043300.15812849
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15006483
92Chronic myeloid leukemia_Homo sapiens_hsa052200.14330385
93Hepatitis B_Homo sapiens_hsa051610.13060549
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.11447013
95Propanoate metabolism_Homo sapiens_hsa006400.11239429
96Non-small cell lung cancer_Homo sapiens_hsa052230.11218353
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.10372092
98Insulin resistance_Homo sapiens_hsa049310.08272208
99Small cell lung cancer_Homo sapiens_hsa052220.06768183
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.05765061

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