KRT18P52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diaphragm development (GO:0060539)9.25743885
2skeletal muscle organ development (GO:0060538)8.60982060
3positive regulation of cell size (GO:0045793)7.69675983
4arginine catabolic process (GO:0006527)7.64163340
5pyrimidine-containing compound salvage (GO:0008655)6.57502072
6pyrimidine nucleoside salvage (GO:0043097)6.57502072
7negative regulation of organelle assembly (GO:1902116)6.49756449
8arginine metabolic process (GO:0006525)6.41892291
9negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)6.29991929
10ribosomal small subunit assembly (GO:0000028)5.74303705
11regulation of nuclear cell cycle DNA replication (GO:0033262)5.58139280
12negative regulation of calcium ion transport into cytosol (GO:0010523)5.51080444
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.35818380
14pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)5.34836097
15UMP biosynthetic process (GO:0006222)5.34836097
16pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)5.34836097
17UMP metabolic process (GO:0046049)5.34836097
18exogenous drug catabolic process (GO:0042738)5.19245386
19regulation of cilium assembly (GO:1902017)5.07654655
20regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)4.95790305
21positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.93487535
22nucleoside salvage (GO:0043174)4.85148818
23regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.84622899
24negative regulation of neurotransmitter transport (GO:0051589)4.83809113
25negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.82686203
26cellular protein complex localization (GO:0034629)4.82203112
27nucleotide salvage (GO:0043173)4.79273411
28respiratory chain complex IV assembly (GO:0008535)4.79012439
29regulation of mitochondrial translation (GO:0070129)4.71196588
30positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.69195590
31response to lipoprotein particle (GO:0055094)4.57007171
32negative regulation of T cell receptor signaling pathway (GO:0050860)4.53778989
33positive regulation of guanylate cyclase activity (GO:0031284)4.41374725
34negative regulation of macrophage differentiation (GO:0045650)4.34367730
35isoprenoid biosynthetic process (GO:0008299)4.30677694
36pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)4.27987236
37negative regulation of vascular permeability (GO:0043116)4.22142870
38positive regulation of sodium ion transmembrane transport (GO:1902307)4.13040856
39regulation of oxidative phosphorylation (GO:0002082)4.12747385
40iron coordination entity transport (GO:1901678)4.12158807
41somite development (GO:0061053)4.08500160
42heme transport (GO:0015886)4.02468676
43regulation of neurotransmitter uptake (GO:0051580)4.00598986
44substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.00403732
45substrate-independent telencephalic tangential migration (GO:0021826)4.00403732
46regulation of guanylate cyclase activity (GO:0031282)3.99918656
47positive regulation of focal adhesion assembly (GO:0051894)3.99658589
48positive regulation of cell junction assembly (GO:1901890)3.99658589
49adenine nucleotide transport (GO:0051503)3.96158492
50nitric oxide biosynthetic process (GO:0006809)3.93239743
51pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.90977607
52negative regulation of potassium ion transport (GO:0043267)3.87097620
53regulation of female receptivity (GO:0045924)3.82055504
54drug catabolic process (GO:0042737)3.80974972
55peripheral nervous system neuron development (GO:0048935)3.79843146
56regulation of stem cell maintenance (GO:2000036)3.74438961
57CTP metabolic process (GO:0046036)3.74259539
58CTP biosynthetic process (GO:0006241)3.74259539
59pyrimidine-containing compound transmembrane transport (GO:0072531)3.72021831
60nitric oxide mediated signal transduction (GO:0007263)3.65815636
61cytochrome complex assembly (GO:0017004)3.58966695
62establishment of tissue polarity (GO:0007164)3.58198824
63establishment of planar polarity (GO:0001736)3.58198824
64negative regulation of protein kinase B signaling (GO:0051898)3.57983865
65positive regulation of signal transduction by p53 class mediator (GO:1901798)3.54146220
66acetyl-CoA metabolic process (GO:0006084)3.52723205
67positive regulation of adherens junction organization (GO:1903393)3.52403080
68regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.50151531
69protein heterotrimerization (GO:0070208)3.48352076
70determination of left/right symmetry (GO:0007368)3.45878626
71positive regulation of receptor biosynthetic process (GO:0010870)3.40672304
72DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.40578598
73female mating behavior (GO:0060180)3.39104602
74positive regulation of DNA-dependent DNA replication (GO:2000105)3.35705838
75pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.34190028
76histone H3-K4 methylation (GO:0051568)3.32193210
77pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.30175167
78determination of bilateral symmetry (GO:0009855)3.26640407
79regulation of respiratory system process (GO:0044065)3.26497038
80phagosome maturation (GO:0090382)3.23855661
81positive regulation of catecholamine secretion (GO:0033605)3.22827096
82regulation of protein deacetylation (GO:0090311)3.20252965
83specification of symmetry (GO:0009799)3.20214918
84negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.18556052
85retinal cone cell development (GO:0046549)3.15515214
86chromatin silencing (GO:0006342)3.15212432
87cell migration in hindbrain (GO:0021535)3.13743633
88axonal fasciculation (GO:0007413)3.12555506
89ribosomal large subunit biogenesis (GO:0042273)3.12395944
90pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.11856395
91protein complex localization (GO:0031503)3.09616937
92positive regulation of cGMP biosynthetic process (GO:0030828)3.09448288
93response to acidic pH (GO:0010447)3.08373187
94ncRNA 3-end processing (GO:0043628)3.07658714
95lateral sprouting from an epithelium (GO:0060601)3.05201810
96regulation of cellular respiration (GO:0043457)3.03888506
97protein localization to kinetochore (GO:0034501)3.02607071
98purine nucleotide transport (GO:0015865)3.02266892
99nucleoside transport (GO:0015858)2.97035328
100neurotransmitter biosynthetic process (GO:0042136)2.95906453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.40432497
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.06383998
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.86530580
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.81352257
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52249679
6HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.49341016
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.47446938
8EZH2_22144423_ChIP-Seq_EOC_Human12.8797309
9NR3C1_21868756_ChIP-Seq_MCF10A_Human1.82702451
10SMAD3_21741376_ChIP-Seq_ESCs_Human1.69437600
11RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60370678
12UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54195255
13JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46006637
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40515544
15SMC4_20622854_ChIP-Seq_HELA_Human1.39166897
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39122328
17KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.38110073
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37938555
19TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36594361
20TET1_21451524_ChIP-Seq_MESCs_Mouse1.35467991
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.34964454
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.34775782
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.34402742
24SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33739712
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31854281
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30235015
27DROSHA_22980978_ChIP-Seq_HELA_Human1.27941887
28TAF2_19829295_ChIP-Seq_ESCs_Human1.25838469
29MYC_18940864_ChIP-ChIP_HL60_Human1.25582663
30ERA_21632823_ChIP-Seq_H3396_Human1.25145922
31VDR_22108803_ChIP-Seq_LS180_Human1.24734658
32GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24374733
33MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22383786
34P68_20966046_ChIP-Seq_HELA_Human1.21829895
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19025568
36P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18731747
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.17025074
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.16378324
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16079070
40AHR_22903824_ChIP-Seq_MCF-7_Human1.15690150
41REST_21632747_ChIP-Seq_MESCs_Mouse1.14859430
42TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14565851
43P53_21459846_ChIP-Seq_SAOS-2_Human1.13125431
44E2F7_22180533_ChIP-Seq_HELA_Human1.12948855
45ERG_20517297_ChIP-Seq_VCAP_Human1.12424728
46KDM2B_26808549_Chip-Seq_K562_Human1.11156838
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.09787156
48TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09453222
49RNF2_27304074_Chip-Seq_NSC_Mouse1.07427142
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07306419
51FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07032424
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06687448
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05450353
54E2F1_20622854_ChIP-Seq_HELA_Human1.04223472
55TP53_22573176_ChIP-Seq_HFKS_Human1.03136381
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02123442
57NANOG_20526341_ChIP-Seq_ESCs_Human1.01768703
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01580191
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00425287
60PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99696850
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99006516
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98400519
63IRF1_19129219_ChIP-ChIP_H3396_Human0.97280402
64ARNT_22903824_ChIP-Seq_MCF-7_Human0.97155340
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97056536
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97056536
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95914511
68SMAD4_21741376_ChIP-Seq_ESCs_Human0.95579918
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94509638
70FOXH1_21741376_ChIP-Seq_ESCs_Human0.94370931
71POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94305768
72EZH2_27294783_Chip-Seq_ESCs_Mouse0.94141024
73AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93423073
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93400084
75SOX2_22085726_ChIP-Seq_NPCs_Mouse0.92606965
76ERG_21242973_ChIP-ChIP_JURKAT_Human0.92136215
77GATA3_21867929_ChIP-Seq_TH1_Mouse0.91994118
78CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91480835
79GATA1_26923725_Chip-Seq_HPCs_Mouse0.91293987
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87457754
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87451826
82FUS_26573619_Chip-Seq_HEK293_Human0.87391334
83NOTCH1_21737748_ChIP-Seq_TLL_Human0.87310759
84PHF8_20622854_ChIP-Seq_HELA_Human0.87196772
85HOXB7_26014856_ChIP-Seq_BT474_Human0.86464445
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86438047
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85737199
88TP53_22127205_ChIP-Seq_IMR90_Human0.84077253
89BCL6_27268052_Chip-Seq_Bcells_Human0.82946607
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.82181133
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.80376729
92OCT4_19829295_ChIP-Seq_ESCs_Human0.79586065
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79323403
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.77890468
95RING1B_27294783_Chip-Seq_NPCs_Mouse0.76269245
96BCOR_27268052_Chip-Seq_Bcells_Human0.76165162
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76015292
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75936456
99P300_27268052_Chip-Seq_Bcells_Human0.75006044
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74676101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.62067568
2MP0003646_muscle_fatigue5.93139075
3MP0002234_abnormal_pharynx_morphology5.60845582
4MP0005645_abnormal_hypothalamus_physiol4.64036074
5MP0003283_abnormal_digestive_organ3.96278760
6MP0004043_abnormal_pH_regulation3.69361045
7MP0008004_abnormal_stomach_pH3.10051689
8MP0004233_abnormal_muscle_weight3.09047027
9MP0010368_abnormal_lymphatic_system2.96553940
10MP0005167_abnormal_blood-brain_barrier2.92487595
11MP0004858_abnormal_nervous_system2.89117908
12MP0009053_abnormal_anal_canal2.68326562
13MP0004084_abnormal_cardiac_muscle2.05061956
14MP0002233_abnormal_nose_morphology2.03516790
15MP0006292_abnormal_olfactory_placode1.93165642
16MP0001501_abnormal_sleep_pattern1.72021206
17MP0008789_abnormal_olfactory_epithelium1.66293056
18MP0000470_abnormal_stomach_morphology1.59343378
19MP0000383_abnormal_hair_follicle1.58297122
20MP0008775_abnormal_heart_ventricle1.56767674
21MP0006082_CNS_inflammation1.55844501
22MP0000467_abnormal_esophagus_morphology1.54443083
23MP0003718_maternal_effect1.53114588
24MP0003045_fibrosis1.52270478
25MP0005499_abnormal_olfactory_system1.49911719
26MP0005394_taste/olfaction_phenotype1.49911719
27MP0001664_abnormal_digestion1.41597815
28MP0008872_abnormal_physiological_respon1.40514597
29MP0002837_dystrophic_cardiac_calcinosis1.39487716
30MP0002132_abnormal_respiratory_system1.35100766
31MP0003937_abnormal_limbs/digits/tail_de1.33756721
32MP0000049_abnormal_middle_ear1.32947074
33MP0000631_abnormal_neuroendocrine_gland1.23927630
34MP0001919_abnormal_reproductive_system1.23823168
35MP0003123_paternal_imprinting1.18693490
36MP0002282_abnormal_trachea_morphology1.17635369
37MP0004885_abnormal_endolymph1.11695077
38MP0003136_yellow_coat_color1.10984767
39MP0002116_abnormal_craniofacial_bone1.10172075
40MP0002109_abnormal_limb_morphology1.09515703
41MP0008877_abnormal_DNA_methylation1.08752034
42MP0006138_congestive_heart_failure1.08740354
43MP0010030_abnormal_orbit_morphology1.02841217
44MP0003122_maternal_imprinting1.02439534
45MP0003119_abnormal_digestive_system1.02000666
46MP0001293_anophthalmia1.00789088
47MP0002098_abnormal_vibrissa_morphology0.95376604
48MP0000955_abnormal_spinal_cord0.94656375
49MP0003938_abnormal_ear_development0.94562589
50MP0010678_abnormal_skin_adnexa0.91966820
51MP0010307_abnormal_tumor_latency0.91090421
52MP0004133_heterotaxia0.90578468
53MP0002272_abnormal_nervous_system0.90530948
54MP0005389_reproductive_system_phenotype0.90097901
55MP0004036_abnormal_muscle_relaxation0.88931112
56MP0001286_abnormal_eye_development0.88627063
57MP0002876_abnormal_thyroid_physiology0.88437897
58MP0000432_abnormal_head_morphology0.84566962
59MP0009745_abnormal_behavioral_response0.84281931
60MP0000733_abnormal_muscle_development0.83093509
61MP0001440_abnormal_grooming_behavior0.82757610
62MP0001984_abnormal_olfaction0.81957174
63MP0000163_abnormal_cartilage_morphology0.80214966
64MP0000537_abnormal_urethra_morphology0.79267191
65MP0009764_decreased_sensitivity_to0.78608888
66MP0002113_abnormal_skeleton_development0.78219727
67MP0001764_abnormal_homeostasis0.77824297
68MP0002102_abnormal_ear_morphology0.76695587
69MP0003942_abnormal_urinary_system0.74707275
70MP0006035_abnormal_mitochondrial_morpho0.74042323
71MP0000538_abnormal_urinary_bladder0.73498575
72MP0004742_abnormal_vestibular_system0.70807696
73MP0000613_abnormal_salivary_gland0.70232974
74MP0001485_abnormal_pinna_reflex0.69915689
75MP0002928_abnormal_bile_duct0.69782376
76MP0002557_abnormal_social/conspecific_i0.67569635
77MP0005332_abnormal_amino_acid0.66613685
78MP0000230_abnormal_systemic_arterial0.66137148
79MP0001879_abnormal_lymphatic_vessel0.63432698
80MP0004130_abnormal_muscle_cell0.62898677
81MP0000428_abnormal_craniofacial_morphol0.62825846
82MP0000767_abnormal_smooth_muscle0.62825559
83MP0008875_abnormal_xenobiotic_pharmacok0.62752859
84MP0009780_abnormal_chondrocyte_physiolo0.61741971
85MP0002009_preneoplasia0.61244485
86MP0009379_abnormal_foot_pigmentation0.60453371
87MP0000372_irregular_coat_pigmentation0.59417613
88MP0004484_altered_response_of0.59001087
89MP0002249_abnormal_larynx_morphology0.57267464
90MP0001970_abnormal_pain_threshold0.54899861
91MP0005197_abnormal_uvea_morphology0.54148849
92MP0002111_abnormal_tail_morphology0.54118773
93MP0002115_abnormal_skeleton_extremities0.53070919
94MP0002168_other_aberrant_phenotype0.52882131
95MP0000778_abnormal_nervous_system0.52819994
96MP0005423_abnormal_somatic_nervous0.51737326
97MP0002127_abnormal_cardiovascular_syste0.51555033
98MP0003633_abnormal_nervous_system0.51003318
99MP0005551_abnormal_eye_electrophysiolog0.49833168
100MP0005076_abnormal_cell_differentiation0.49701135

Predicted human phenotypes

RankGene SetZ-score
1Sparse lateral eyebrow (HP:0005338)7.78632424
2Elevated erythrocyte sedimentation rate (HP:0003565)7.47422802
3Peritonitis (HP:0002586)7.04433746
4Lip pit (HP:0100267)5.78157133
5Autoimmune thrombocytopenia (HP:0001973)5.49646128
6Anal stenosis (HP:0002025)5.33215106
7Intestinal fistula (HP:0100819)4.93532160
8Depressed nasal tip (HP:0000437)4.82635679
9Progressive cerebellar ataxia (HP:0002073)4.72924125
10Confusion (HP:0001289)4.61765824
11Shawl scrotum (HP:0000049)4.12515247
12Abnormality of the fingertips (HP:0001211)4.10524520
13Short 5th finger (HP:0009237)4.00479846
14Preaxial foot polydactyly (HP:0001841)3.95968532
15High anterior hairline (HP:0009890)3.91965923
16Broad hallux (HP:0010055)3.88723956
17Posterior subcapsular cataract (HP:0007787)3.72721813
18Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.71349095
19Ureteral stenosis (HP:0000071)3.70458865
20Down-sloping shoulders (HP:0200021)3.63747502
21Ectopic kidney (HP:0000086)3.50091065
22Concave nail (HP:0001598)3.47430857
23Ureteral obstruction (HP:0006000)3.39732686
24Broad toe (HP:0001837)3.20745822
25Pterygium (HP:0001059)3.20629058
26Vertebral hypoplasia (HP:0008417)3.17383384
27Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.17383384
28Abnormality of the peritoneum (HP:0002585)2.98710995
29Breast hypoplasia (HP:0003187)2.92238571
30Popliteal pterygium (HP:0009756)2.89404190
31Periauricular skin pits (HP:0100277)2.75522618
32Preauricular pit (HP:0004467)2.75522618
33Generalized aminoaciduria (HP:0002909)2.69108113
34Lower limb hyperreflexia (HP:0002395)2.66499130
35Supernumerary spleens (HP:0009799)2.54483920
36Pheochromocytoma (HP:0002666)2.45529100
37Polydipsia (HP:0001959)2.43629256
38Abnormal drinking behavior (HP:0030082)2.43629256
39Absent eyebrow (HP:0002223)2.42365165
40Long palpebral fissure (HP:0000637)2.40373032
41Coronal craniosynostosis (HP:0004440)2.39869032
42Abnormal biliary tract physiology (HP:0012439)2.37510140
43Bile duct proliferation (HP:0001408)2.37510140
44Abnormality of the renal cortex (HP:0011035)2.37472905
45Ectropion (HP:0000656)2.34452263
46Respiratory distress (HP:0002098)2.32703987
47Neuroendocrine neoplasm (HP:0100634)2.31068791
48Absent thumb (HP:0009777)2.21642911
49Fragile nails (HP:0001808)2.19934479
50Tubular atrophy (HP:0000092)2.19658262
51Renal cell carcinoma (HP:0005584)2.16420576
52Renal cortical cysts (HP:0000803)2.14119357
53Bilateral sensorineural hearing impairment (HP:0008619)2.13062868
54Pancreatic cysts (HP:0001737)2.09690073
55Ridged nail (HP:0001807)2.07640473
56Subcapsular cataract (HP:0000523)2.07073163
57Abnormal number of incisors (HP:0011064)2.06073790
58Abnormal hair whorl (HP:0010721)2.03301881
59Preauricular skin tag (HP:0000384)1.97529138
60Amblyopia (HP:0000646)1.94274099
61Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93809469
62Facial cleft (HP:0002006)1.93521299
63Tinnitus (HP:0000360)1.92097252
64Aplasia involving bones of the upper limbs (HP:0009823)1.91408259
65Aplasia of the phalanges of the hand (HP:0009802)1.91408259
66Aplasia involving bones of the extremities (HP:0009825)1.91408259
67Urinary glycosaminoglycan excretion (HP:0003541)1.89950855
68Mucopolysacchariduria (HP:0008155)1.89950855
69Hypoglycemic coma (HP:0001325)1.89627644
70Congenital hip dislocation (HP:0001374)1.89432911
71Midline defect of the nose (HP:0004122)1.88596894
72Wide intermamillary distance (HP:0006610)1.87126384
73Uterine leiomyosarcoma (HP:0002891)1.86952240
74Leiomyosarcoma (HP:0100243)1.86952240
75Natal tooth (HP:0000695)1.85444189
76Broad thumb (HP:0011304)1.85082552
77Hypoparathyroidism (HP:0000829)1.81983781
78Abnormality of the 2nd finger (HP:0004100)1.80797645
79Abnormality of polysaccharide metabolism (HP:0011012)1.80755876
80Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80755876
81Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80755876
82Severe visual impairment (HP:0001141)1.80522109
83Transitional cell carcinoma of the bladder (HP:0006740)1.78688653
84Abnormality of the periventricular white matter (HP:0002518)1.78458931
85Blue sclerae (HP:0000592)1.77543495
86Prolonged neonatal jaundice (HP:0006579)1.77075364
87Tetany (HP:0001281)1.75798203
88Narrow palate (HP:0000189)1.74046581
89Morphological abnormality of the inner ear (HP:0011390)1.71446613
90Anal atresia (HP:0002023)1.71046801
91Aplasia/Hypoplasia of the nipples (HP:0006709)1.70589277
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69554914
93Broad metatarsal (HP:0001783)1.68912398
94Neonatal short-limb short stature (HP:0008921)1.67951081
95Self-mutilation (HP:0000742)1.66819790
96Hyperthyroidism (HP:0000836)1.66756491
97Woolly hair (HP:0002224)1.65736292
98Birth length less than 3rd percentile (HP:0003561)1.64968268
99Broad phalanges of the hand (HP:0009768)1.64352198
100Chronic bronchitis (HP:0004469)1.64020968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK46.42385591
2STK246.37776673
3STK396.00546064
4BMPR1B3.85921787
5PINK13.85797873
6EPHB23.74776647
7CCNB13.22226526
8EEF2K2.72004648
9MAP3K32.69455917
10MAP3K22.67105446
11ILK2.54829124
12ZAK2.10596067
13JAK32.05826527
14TIE11.82057245
15CDC71.74546203
16WNK11.65924325
17MAPKAPK31.65511277
18FRK1.65309635
19NTRK21.63196416
20CHEK21.43673610
21CAMK11.34887151
22RPS6KB21.22063632
23CAMK41.18044005
24RPS6KA61.09702134
25PRKCQ1.09674736
26ADRBK21.04619818
27DMPK1.01775463
28RPS6KC10.97466687
29RPS6KL10.97466687
30OXSR10.96086161
31MAPKAPK50.96058086
32VRK20.95767957
33TRPM70.95526711
34BCKDK0.87453595
35DAPK20.83303621
36WNK30.78676588
37DYRK30.78584382
38TNK20.76119934
39EPHA20.70037645
40GRK10.67673666
41PKN10.65914683
42MINK10.59885552
43MAPK130.57858471
44CAMK1G0.54046266
45RPS6KA20.52331704
46NUAK10.51608789
47STK110.51354524
48ADRBK10.49484886
49CAMK1D0.45668231
50DYRK20.42867875
51SRPK10.42540145
52PRKCZ0.42249128
53CSNK1G20.39746144
54BMX0.38502645
55PRKCI0.36079086
56PIK3CA0.35627212
57TNIK0.35538368
58CSNK1G30.35531786
59PRKCD0.29308100
60CSNK1A1L0.29010287
61PRKCE0.28988026
62PLK10.28961069
63CDK70.26139339
64CDK190.25888784
65IRAK30.25730288
66PRKCG0.24511446
67PASK0.24379900
68PNCK0.23685695
69CAMKK10.22257553
70CAMKK20.22030102
71CDK90.21668209
72MAP4K20.20761805
73EIF2AK20.20728108
74VRK10.20520109
75TTK0.19425742
76PRKCA0.18853673
77STK40.18697126
78TAF10.17324158
79PRKACA0.16886101
80MAP2K70.15529883
81MAP3K90.15335596
82FGFR20.14828251
83CSNK1G10.14598732
84CSNK1E0.12828252
85PRKACG0.12373945
86CSNK2A10.12236551
87TLK10.11805092
88ABL20.11502778
89KIT0.11232261
90PLK30.10998999
91NTRK30.10922929
92PRKAA10.10491338
93ERBB20.10132433
94EGFR0.08951878
95ROCK10.08705402
96RPS6KA50.08604974
97WEE10.08589601
98PTK2B0.07972912
99GRK50.07880587
100CDK20.07595187

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.65218307
2Arginine biosynthesis_Homo sapiens_hsa002204.04183523
3Phototransduction_Homo sapiens_hsa047443.76170666
4Collecting duct acid secretion_Homo sapiens_hsa049663.42462656
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.13004051
6Lysine degradation_Homo sapiens_hsa003102.67415507
7Drug metabolism - other enzymes_Homo sapiens_hsa009832.62052711
8One carbon pool by folate_Homo sapiens_hsa006702.44511618
9Sulfur relay system_Homo sapiens_hsa041222.32393823
10Ribosome_Homo sapiens_hsa030102.28748548
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00543902
12Vitamin digestion and absorption_Homo sapiens_hsa049771.90174175
13Oxidative phosphorylation_Homo sapiens_hsa001901.89818285
14AMPK signaling pathway_Homo sapiens_hsa041521.88092487
15Pyrimidine metabolism_Homo sapiens_hsa002401.82951442
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68704185
17Basal transcription factors_Homo sapiens_hsa030221.57681765
18RNA polymerase_Homo sapiens_hsa030201.56142107
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55662143
20Circadian entrainment_Homo sapiens_hsa047131.53577226
21Peroxisome_Homo sapiens_hsa041461.47586302
22Nitrogen metabolism_Homo sapiens_hsa009101.42133942
23Salivary secretion_Homo sapiens_hsa049701.27581148
24Cardiac muscle contraction_Homo sapiens_hsa042601.26096477
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18282257
26Arginine and proline metabolism_Homo sapiens_hsa003301.16981459
27Selenocompound metabolism_Homo sapiens_hsa004501.15986322
28ABC transporters_Homo sapiens_hsa020101.11611108
29Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.09961027
30Nicotine addiction_Homo sapiens_hsa050331.08864359
31Nucleotide excision repair_Homo sapiens_hsa034201.05180601
32Dopaminergic synapse_Homo sapiens_hsa047281.02209038
33Parkinsons disease_Homo sapiens_hsa050121.02018587
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00874504
35Synaptic vesicle cycle_Homo sapiens_hsa047211.00614459
36Butanoate metabolism_Homo sapiens_hsa006500.98869263
37Homologous recombination_Homo sapiens_hsa034400.98500964
38Linoleic acid metabolism_Homo sapiens_hsa005910.98099116
39Folate biosynthesis_Homo sapiens_hsa007900.97880661
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.97848755
41Basal cell carcinoma_Homo sapiens_hsa052170.95871985
42Olfactory transduction_Homo sapiens_hsa047400.94379446
43Fat digestion and absorption_Homo sapiens_hsa049750.92988500
44Alzheimers disease_Homo sapiens_hsa050100.90085364
45Hedgehog signaling pathway_Homo sapiens_hsa043400.79850991
46Huntingtons disease_Homo sapiens_hsa050160.79554713
47Tryptophan metabolism_Homo sapiens_hsa003800.78177895
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.77835320
49Chemical carcinogenesis_Homo sapiens_hsa052040.76184698
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75353035
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74808257
52Morphine addiction_Homo sapiens_hsa050320.74614675
53RNA degradation_Homo sapiens_hsa030180.74267071
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.73899267
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73597905
56Glycerolipid metabolism_Homo sapiens_hsa005610.71859884
57Vibrio cholerae infection_Homo sapiens_hsa051100.69085422
58Taste transduction_Homo sapiens_hsa047420.67996167
59Purine metabolism_Homo sapiens_hsa002300.62202700
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.62032817
61Hippo signaling pathway_Homo sapiens_hsa043900.58538119
62Retinol metabolism_Homo sapiens_hsa008300.56242300
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54807344
64Long-term depression_Homo sapiens_hsa047300.53966631
65Caffeine metabolism_Homo sapiens_hsa002320.52650274
66Metabolic pathways_Homo sapiens_hsa011000.52515440
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51924484
68Phagosome_Homo sapiens_hsa041450.51660821
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51384397
70Insulin signaling pathway_Homo sapiens_hsa049100.49832746
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49588096
72cAMP signaling pathway_Homo sapiens_hsa040240.48041990
73Oxytocin signaling pathway_Homo sapiens_hsa049210.47800638
74Calcium signaling pathway_Homo sapiens_hsa040200.47240424
75Proteasome_Homo sapiens_hsa030500.46083743
76DNA replication_Homo sapiens_hsa030300.45230507
77TGF-beta signaling pathway_Homo sapiens_hsa043500.44706569
78N-Glycan biosynthesis_Homo sapiens_hsa005100.43735055
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43359662
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42987933
81Tight junction_Homo sapiens_hsa045300.41303749
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.40985234
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40210916
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.39458827
85Ovarian steroidogenesis_Homo sapiens_hsa049130.39093308
86Dilated cardiomyopathy_Homo sapiens_hsa054140.38963473
87Fanconi anemia pathway_Homo sapiens_hsa034600.38394732
88Rheumatoid arthritis_Homo sapiens_hsa053230.36640650
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.35766830
90mRNA surveillance pathway_Homo sapiens_hsa030150.35756494
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35054180
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34899042
93Galactose metabolism_Homo sapiens_hsa000520.34755958
94ECM-receptor interaction_Homo sapiens_hsa045120.33159507
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32751494
96Starch and sucrose metabolism_Homo sapiens_hsa005000.32101816
97Alcoholism_Homo sapiens_hsa050340.31346171
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31201323
99Ether lipid metabolism_Homo sapiens_hsa005650.30972428
100Adherens junction_Homo sapiens_hsa045200.30419550

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