ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	spermatid development (GO:0007286)	7.08490099
2	sperm motility (GO:0030317)	6.65533861
3	synapsis (GO:0007129)	6.46155587
4	meiosis I (GO:0007127)	6.46081199
5	male meiosis I (GO:0007141)	6.33197069
6	piRNA metabolic process (GO:0034587)	6.25847266
7	chromosome organization involved in meiosis (GO:0070192)	6.24567288
8	male meiosis (GO:0007140)	6.22860955
9	synaptonemal complex assembly (GO:0007130)	6.20992005
10	acrosome reaction (GO:0007340)	5.96526038
11	DNA methylation involved in gamete generation (GO:0043046)	5.69951585
12	synaptonemal complex organization (GO:0070193)	5.56941024
13	fusion of sperm to egg plasma membrane (GO:0007342)	5.38211715
14	regulation of meiosis I (GO:0060631)	5.20657156
15	meiotic nuclear division (GO:0007126)	5.17901822
16	microtubule depolymerization (GO:0007019)	5.15153843
17	rRNA methylation (GO:0031167)	4.88282174
18	protein polyglutamylation (GO:0018095)	4.84901059
19	meiotic cell cycle process (GO:1903046)	4.78075143
20	meiotic chromosome segregation (GO:0045132)	4.76548874
21	sperm-egg recognition (GO:0035036)	4.68499344
22	reciprocal meiotic recombination (GO:0007131)	4.67121594
23	reciprocal DNA recombination (GO:0035825)	4.67121594
24	binding of sperm to zona pellucida (GO:0007339)	4.56423221
25	rRNA modification (GO:0000154)	4.49413134
26	positive regulation of mitochondrial fission (GO:0090141)	4.43953251
27	DNA packaging (GO:0006323)	4.43287617
28	resolution of meiotic recombination intermediates (GO:0000712)	4.42005599
29	centriole replication (GO:0007099)	4.35230311
30	microtubule polymerization or depolymerization (GO:0031109)	4.31781450
31	multicellular organism reproduction (GO:0032504)	4.28300059
32	axonemal dynein complex assembly (GO:0070286)	4.26234448
33	spermatogenesis (GO:0007283)	4.18583227
34	male gamete generation (GO:0048232)	4.18299244
35	germ cell development (GO:0007281)	4.12575704
36	plasma membrane fusion (GO:0045026)	4.08321476
37	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.05988763
38	protein targeting to Golgi (GO:0000042)	3.91686439
39	gamete generation (GO:0007276)	3.91465143
40	motile cilium assembly (GO:0044458)	3.89063058
41	single strand break repair (GO:0000012)	3.84420195
42	cell-cell recognition (GO:0009988)	3.84236623
43	establishment of protein localization to Golgi (GO:0072600)	3.83536506
44	spermatid nucleus differentiation (GO:0007289)	3.82819245
45	pyrimidine nucleotide catabolic process (GO:0006244)	3.81805867
46	fertilization (GO:0009566)	3.81149538
47	chromosome condensation (GO:0030261)	3.80729548
48	centriole assembly (GO:0098534)	3.73541725
49	seminiferous tubule development (GO:0072520)	3.73011003
50	polyamine biosynthetic process (GO:0006596)	3.67919053
51	peptidyl-arginine omega-N-methylation (GO:0035247)	3.67691750
52	sperm capacitation (GO:0048240)	3.67644182
53	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.61555092
54	single fertilization (GO:0007338)	3.60388298
55	DNA synthesis involved in DNA repair (GO:0000731)	3.58079691
56	epithelial cilium movement (GO:0003351)	3.56278651
57	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.55945153
58	mitochondrion degradation (GO:0000422)	3.50253727
59	cilium or flagellum-dependent cell motility (GO:0001539)	3.47943813
60	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.37713653
61	microtubule severing (GO:0051013)	3.33177577
62	phosphatidylethanolamine metabolic process (GO:0046337)	3.31715872
63	calcium ion-dependent exocytosis (GO:0017156)	3.30913817
64	mitotic G1 DNA damage checkpoint (GO:0031571)	3.29848311
65	reproduction (GO:0000003)	3.27172611
66	regulation of cilium movement (GO:0003352)	3.26732894
67	mitotic G1/S transition checkpoint (GO:0044819)	3.22061021
68	peptidyl-arginine methylation (GO:0018216)	3.16918330
69	peptidyl-arginine N-methylation (GO:0035246)	3.16918330
70	histone arginine methylation (GO:0034969)	3.15659035
71	G1 DNA damage checkpoint (GO:0044783)	3.14057796
72	histone exchange (GO:0043486)	3.11982980
73	regulation of mitochondrial fission (GO:0090140)	3.10059752
74	glomerular visceral epithelial cell development (GO:0072015)	3.08125664
75	base-excision repair, AP site formation (GO:0006285)	3.05762349
76	male sex determination (GO:0030238)	3.02302324
77	histone H3-K9 demethylation (GO:0033169)	3.01466294
78	sister chromatid cohesion (GO:0007062)	3.01367149
79	multicellular organismal reproductive process (GO:0048609)	2.98663998
80	organic cation transport (GO:0015695)	2.96545115
81	female gamete generation (GO:0007292)	2.94900548
82	protein localization to Golgi apparatus (GO:0034067)	2.90926389
83	regulation of centriole replication (GO:0046599)	2.90406048
84	cilium movement (GO:0003341)	2.89020701
85	regulation of cardiac muscle cell apoptotic process (GO:0010665)	2.88706160
86	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	2.86783656
87	peptidyl-threonine dephosphorylation (GO:0035970)	2.86024653
88	axoneme assembly (GO:0035082)	2.84387323
89	cellular biogenic amine biosynthetic process (GO:0042401)	2.82782262
90	proteasome assembly (GO:0043248)	2.82267616
91	mismatch repair (GO:0006298)	2.80800248
92	amine biosynthetic process (GO:0009309)	2.79931859
93	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.77843198
94	glomerular epithelial cell development (GO:0072310)	2.73442142
95	oogenesis (GO:0048477)	2.73261448
96	negative regulation of inclusion body assembly (GO:0090084)	2.65959705
97	cerebral cortex neuron differentiation (GO:0021895)	2.62932808
98	positive regulation of mitochondrial membrane permeability (GO:0035794)	2.56542803
99	gene silencing by RNA (GO:0031047)	2.55167279
100	microtubule nucleation (GO:0007020)	2.54163165

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.36036930
2	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.32701962
3	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.81530022
4	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.28158402
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.24418380
6	ERA_21632823_ChIP-Seq_H3396_Human	2.15764372
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.03437243
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.03339009
9	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.97266998
10	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.96783500
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.96597834
12	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.96337197
13	CBP_20019798_ChIP-Seq_JUKART_Human	1.96337197
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.88930336
15	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.83849571
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79279153
17	ZNF274_21170338_ChIP-Seq_K562_Hela	1.77045543
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74436561
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.73455612
20	RAC3_21632823_ChIP-Seq_H3396_Human	1.72313637
21	NANOG_20526341_ChIP-Seq_ESCs_Human	1.70002042
22	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.67951910
23	MYC_19829295_ChIP-Seq_ESCs_Human	1.67387553
24	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64257700
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.64257700
26	BCL6_27268052_Chip-Seq_Bcells_Human	1.62899362
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.60369561
28	VDR_22108803_ChIP-Seq_LS180_Human	1.57872268
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.57429799
30	OCT4_20526341_ChIP-Seq_ESCs_Human	1.56453274
31	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.54167072
32	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.52766030
33	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.51343718
34	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.47694418
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47609626
36	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.47097154
37	E2F1_20622854_ChIP-Seq_HELA_Human	1.46859669
38	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.46383003
39	CTCF_20526341_ChIP-Seq_ESCs_Human	1.45407692
40	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.41731036
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.41440826
42	BCOR_27268052_Chip-Seq_Bcells_Human	1.40891953
43	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.39558874
44	P68_20966046_ChIP-Seq_HELA_Human	1.39382959
45	FUS_26573619_Chip-Seq_HEK293_Human	1.38509177
46	TAF2_19829295_ChIP-Seq_ESCs_Human	1.38400308
47	PHF8_20622854_ChIP-Seq_HELA_Human	1.38043985
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.37671783
49	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37549779
50	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.37128893
51	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.35406065
52	GABP_19822575_ChIP-Seq_HepG2_Human	1.30125722
53	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.29684760
54	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.29627527
55	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.29032484
56	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.28649418
57	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.27871550
58	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.27146079
59	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.26155989
60	HOXB7_26014856_ChIP-Seq_BT474_Human	1.25734168
61	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.25440339
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.25390305
63	CTCF_27219007_Chip-Seq_Bcells_Human	1.25321095
64	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.24892126
65	P300_27268052_Chip-Seq_Bcells_Human	1.24810866
66	ERG_20517297_ChIP-Seq_VCAP_Human	1.23853836
67	KDM5A_27292631_Chip-Seq_BREAST_Human	1.23179718
68	NCOR_22424771_ChIP-Seq_293T_Human	1.22971478
69	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.22553562
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21909092
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21909092
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19919045
73	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.17724835
74	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.16870160
75	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.14587126
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13787601
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13334148
78	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.12956203
79	VDR_23849224_ChIP-Seq_CD4+_Human	1.12316264
80	ER_23166858_ChIP-Seq_MCF-7_Human	1.11500801
81	RBPJ_21746931_ChIP-Seq_IB4_Human	1.10432434
82	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.10081248
83	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.09683924
84	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.09539976
85	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09486054
86	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.08507264
87	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07048554
88	PHF8_20622853_ChIP-Seq_HELA_Human	1.06938245
89	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.06400485
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05816266
91	P53_21459846_ChIP-Seq_SAOS-2_Human	1.04234270
92	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.04177028
93	SMC4_20622854_ChIP-Seq_HELA_Human	1.03573660
94	AR_20517297_ChIP-Seq_VCAP_Human	1.02799014
95	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.01351760
96	FOXP3_21729870_ChIP-Seq_TREG_Human	1.00852680
97	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.98497556
98	ETV1_20927104_ChIP-Seq_GIST48_Human	0.98050229
99	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.97449924
100	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.96646749

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.09230492
2	MP0008877_abnormal_DNA_methylation	3.85358102
3	MP0003698_abnormal_male_reproductive	3.76154730
4	MP0001929_abnormal_gametogenesis	3.73301434
5	MP0002210_abnormal_sex_determination	3.27210986
6	MP0005377_hearing/vestibular/ear_phenot	2.69467810
7	MP0003878_abnormal_ear_physiology	2.69467810
8	MP0005670_abnormal_white_adipose	2.67074202
9	MP0002234_abnormal_pharynx_morphology	2.58953041
10	MP0001145_abnormal_male_reproductive	2.52827532
11	MP0002160_abnormal_reproductive_system	2.43580161
12	MP0000653_abnormal_sex_gland	2.32304749
13	MP0000566_synostosis	2.25508986
14	MP0002161_abnormal_fertility/fecundity	2.11609076
15	MP0003718_maternal_effect	2.00968413
16	MP0000678_abnormal_parathyroid_gland	2.00001775
17	MP0008058_abnormal_DNA_repair	1.94211312
18	MP0003693_abnormal_embryo_hatching	1.91243140
19	MP0005365_abnormal_bile_salt	1.83374124
20	MP0006292_abnormal_olfactory_placode	1.81235841
21	MP0005394_taste/olfaction_phenotype	1.78694587
22	MP0005499_abnormal_olfactory_system	1.78694587
23	MP0005085_abnormal_gallbladder_physiolo	1.72053612
24	MP0003646_muscle_fatigue	1.67879408
25	MP0002132_abnormal_respiratory_system	1.62431895
26	MP0005389_reproductive_system_phenotype	1.52590864
27	MP0004957_abnormal_blastocyst_morpholog	1.51106666
28	MP0008789_abnormal_olfactory_epithelium	1.48917768
29	MP0009697_abnormal_copulation	1.42483766
30	MP0006036_abnormal_mitochondrial_physio	1.39691937
31	MP0001485_abnormal_pinna_reflex	1.37797840
32	MP0008995_early_reproductive_senescence	1.36804271
33	MP0002249_abnormal_larynx_morphology	1.32891997
34	MP0000049_abnormal_middle_ear	1.32502398
35	MP0010030_abnormal_orbit_morphology	1.30815679
36	MP0006035_abnormal_mitochondrial_morpho	1.29162284
37	MP0002653_abnormal_ependyma_morphology	1.16114926
38	MP0005646_abnormal_pituitary_gland	1.15770164
39	MP0003879_abnormal_hair_cell	1.14423038
40	MP0003077_abnormal_cell_cycle	1.14388668
41	MP0008004_abnormal_stomach_pH	1.13234769
42	MP0002138_abnormal_hepatobiliary_system	1.11948555
43	MP0005332_abnormal_amino_acid	1.11502609
44	MP0001119_abnormal_female_reproductive	1.10227534
45	MP0005360_urolithiasis	1.08056169
46	MP0005379_endocrine/exocrine_gland_phen	1.08038947
47	MP0008932_abnormal_embryonic_tissue	1.07903810
48	MP0001764_abnormal_homeostasis	1.06434146
49	MP0005551_abnormal_eye_electrophysiolog	1.05476288
50	MP0005083_abnormal_biliary_tract	1.03860128
51	MP0002127_abnormal_cardiovascular_syste	1.03841723
52	MP0010386_abnormal_urinary_bladder	1.00424891
53	MP0009053_abnormal_anal_canal	1.00278038
54	MP0001905_abnormal_dopamine_level	0.98945364
55	MP0003936_abnormal_reproductive_system	0.97481554
56	MP0002735_abnormal_chemical_nociception	0.95208913
57	MP0001968_abnormal_touch/_nociception	0.92855215
58	MP0000631_abnormal_neuroendocrine_gland	0.92017599
59	MP0001963_abnormal_hearing_physiology	0.91300383
60	MP0004742_abnormal_vestibular_system	0.90966069
61	MP0003119_abnormal_digestive_system	0.90931883
62	MP0001293_anophthalmia	0.89925979
63	MP0003186_abnormal_redox_activity	0.89480525
64	MP0001486_abnormal_startle_reflex	0.87277472
65	MP0002822_catalepsy	0.86166329
66	MP0003937_abnormal_limbs/digits/tail_de	0.86053335
67	MP0000026_abnormal_inner_ear	0.85591352
68	MP0009745_abnormal_behavioral_response	0.85450052
69	MP0010094_abnormal_chromosome_stability	0.85062749
70	MP0001984_abnormal_olfaction	0.84233606
71	MP0004133_heterotaxia	0.83654245
72	MP0001348_abnormal_lacrimal_gland	0.80429615
73	MP0002163_abnormal_gland_morphology	0.78556553
74	MP0003315_abnormal_perineum_morphology	0.77974773
75	MP0002272_abnormal_nervous_system	0.77242635
76	MP0003121_genomic_imprinting	0.77033164
77	MP0006276_abnormal_autonomic_nervous	0.76528289
78	MP0003567_abnormal_fetal_cardiomyocyte	0.75816209
79	MP0003699_abnormal_female_reproductive	0.74566286
80	MP0002102_abnormal_ear_morphology	0.74410928
81	MP0005451_abnormal_body_composition	0.73202683
82	MP0005253_abnormal_eye_physiology	0.71850979
83	MP0005395_other_phenotype	0.71347335
84	MP0000538_abnormal_urinary_bladder	0.70513781
85	MP0000427_abnormal_hair_cycle	0.65390576
86	MP0005167_abnormal_blood-brain_barrier	0.63665085
87	MP0005084_abnormal_gallbladder_morpholo	0.63430902
88	MP0002254_reproductive_system_inflammat	0.63407871
89	MP0002282_abnormal_trachea_morphology	0.62437750
90	MP0002572_abnormal_emotion/affect_behav	0.61167344
91	MP0002557_abnormal_social/conspecific_i	0.60959745
92	MP0000470_abnormal_stomach_morphology	0.60636257
93	MP0001529_abnormal_vocalization	0.59886316
94	MP0001919_abnormal_reproductive_system	0.59619595
95	MP0001666_abnormal_nutrient_absorption	0.59499034
96	MP0005310_abnormal_salivary_gland	0.58706591
97	MP0009046_muscle_twitch	0.57869190
98	MP0003137_abnormal_impulse_conducting	0.57733900
99	MP0005647_abnormal_sex_gland	0.57438191
100	MP0002938_white_spotting	0.56152249

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	4.68763097
2	Absent/shortened dynein arms (HP:0200106)	4.49579540
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.49579540
4	Hyperventilation (HP:0002883)	4.24447768
5	Chronic hepatic failure (HP:0100626)	4.10440001
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.03846456
7	Severe visual impairment (HP:0001141)	3.79045038
8	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.77327663
9	Abnormal respiratory motile cilium physiology (HP:0012261)	3.68213606
10	Congenital malformation of the right heart (HP:0011723)	3.62791448
11	Double outlet right ventricle (HP:0001719)	3.62791448
12	Abnormal rod and cone electroretinograms (HP:0008323)	3.33372080
13	Nephronophthisis (HP:0000090)	3.30202518
14	Attenuation of retinal blood vessels (HP:0007843)	3.27735285
15	Abnormal ciliary motility (HP:0012262)	3.17886304
16	Decreased central vision (HP:0007663)	3.13958205
17	Pancreatic fibrosis (HP:0100732)	3.09495351
18	Sclerocornea (HP:0000647)	3.08310730
19	Abnormal respiratory motile cilium morphology (HP:0005938)	3.03289928
20	Abnormal respiratory epithelium morphology (HP:0012253)	3.03289928
21	Infertility (HP:0000789)	3.01405275
22	Methylmalonic aciduria (HP:0012120)	2.97785322
23	Colon cancer (HP:0003003)	2.93314484
24	Pancreatic cysts (HP:0001737)	2.82379018
25	Bony spicule pigmentary retinopathy (HP:0007737)	2.80741680
26	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.69431005
27	Abnormality of the renal medulla (HP:0100957)	2.65491417
28	True hermaphroditism (HP:0010459)	2.58130066
29	Nasal polyposis (HP:0100582)	2.56990285
30	Cystic liver disease (HP:0006706)	2.56584421
31	Chronic bronchitis (HP:0004469)	2.54303086
32	Molar tooth sign on MRI (HP:0002419)	2.44749674
33	Abnormality of midbrain morphology (HP:0002418)	2.44749674
34	Upper limb muscle weakness (HP:0003484)	2.40391942
35	Tubulointerstitial abnormality (HP:0001969)	2.38261476
36	Male infertility (HP:0003251)	2.36845968
37	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.34431908
38	Rhinitis (HP:0012384)	2.34065521
39	Occipital encephalocele (HP:0002085)	2.32250755
40	Abnormal drinking behavior (HP:0030082)	2.31131588
41	Polydipsia (HP:0001959)	2.31131588
42	Resting tremor (HP:0002322)	2.30330177
43	Male pseudohermaphroditism (HP:0000037)	2.30214553
44	Neoplasm of the adrenal cortex (HP:0100641)	2.29275924
45	Amelogenesis imperfecta (HP:0000705)	2.28517430
46	Insulin-resistant diabetes mellitus (HP:0000831)	2.26955781
47	Abnormality of the aortic arch (HP:0012303)	2.21694715
48	Anencephaly (HP:0002323)	2.20338524
49	Amblyopia (HP:0000646)	2.20230553
50	Type II lissencephaly (HP:0007260)	2.20185293
51	Abnormality of macular pigmentation (HP:0008002)	2.18648052
52	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.15021940
53	Prolonged neonatal jaundice (HP:0006579)	2.14296829
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.12849735
55	Optic nerve hypoplasia (HP:0000609)	2.08337215
56	Hypoplasia of the thymus (HP:0000778)	2.05102412
57	Acute necrotizing encephalopathy (HP:0006965)	2.01592694
58	Acute encephalopathy (HP:0006846)	2.01287327
59	Hyperkalemia (HP:0002153)	2.00772464
60	Type I transferrin isoform profile (HP:0003642)	2.00738516
61	Congenital hepatic fibrosis (HP:0002612)	1.97410895
62	Cerebellar dysplasia (HP:0007033)	1.95998718
63	Abnormality of the ileum (HP:0001549)	1.95352728
64	Polyuria (HP:0000103)	1.94240951
65	Supernumerary spleens (HP:0009799)	1.94130691
66	Hypoplastic left heart (HP:0004383)	1.92453259
67	Preaxial hand polydactyly (HP:0001177)	1.91086652
68	Renal Fanconi syndrome (HP:0001994)	1.90554933
69	Meckel diverticulum (HP:0002245)	1.89727346
70	Abnormal protein glycosylation (HP:0012346)	1.89594497
71	Abnormal glycosylation (HP:0012345)	1.89594497
72	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.89594497
73	Abnormal protein N-linked glycosylation (HP:0012347)	1.89594497
74	Abnormality of dental color (HP:0011073)	1.86715647
75	Optic nerve coloboma (HP:0000588)	1.86709088
76	Abnormal urine output (HP:0012590)	1.86257357
77	Abnormal ventriculo-arterial connection (HP:0011563)	1.86232083
78	Transposition of the great arteries (HP:0001669)	1.86232083
79	Abnormal connection of the cardiac segments (HP:0011545)	1.86232083
80	Abnormal mitochondria in muscle tissue (HP:0008316)	1.85968543
81	Abnormality of the preputium (HP:0100587)	1.84987573
82	Small intestinal stenosis (HP:0012848)	1.83241112
83	Duodenal stenosis (HP:0100867)	1.83241112
84	Abnormality of renal excretion (HP:0011036)	1.81915612
85	Impaired vibration sensation in the lower limbs (HP:0002166)	1.81193982
86	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80728359
87	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.80583481
88	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.80272528
89	Hypoplasia of the uterus (HP:0000013)	1.80155127
90	Abnormality of the nasal mucosa (HP:0000433)	1.78857604
91	Abnormality of cochlea (HP:0000375)	1.78170524
92	Absent thumb (HP:0009777)	1.78047959
93	Tetany (HP:0001281)	1.77953418
94	Hand muscle atrophy (HP:0009130)	1.77193227
95	Horizontal nystagmus (HP:0000666)	1.76719074
96	Tubular atrophy (HP:0000092)	1.75197410
97	Sloping forehead (HP:0000340)	1.75033412
98	Stage 5 chronic kidney disease (HP:0003774)	1.73321636
99	Abnormality of DNA repair (HP:0003254)	1.72265077
100	Preauricular pit (HP:0004467)	1.71696218

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.60658243
2	TAF1	5.14578052
3	PLK4	4.72264591
4	PNCK	3.78195377
5	SMG1	3.43564111
6	NUAK1	3.07865481
7	PINK1	2.65741603
8	PLK2	2.37004598
9	CAMK1G	2.30318066
10	CSNK1G3	2.16872560
11	CDK19	2.10566940
12	VRK1	2.09781618
13	CSNK1A1L	1.89169938
14	ZAK	1.85734714
15	TESK1	1.78556157
16	PRKD3	1.72942597
17	CSNK1G2	1.71121493
18	CSNK1G1	1.66040159
19	INSRR	1.63834303
20	STK38L	1.60201849
21	DYRK2	1.55173789
22	GRK5	1.51847411
23	BRD4	1.51766052
24	MAPKAPK5	1.47882697
25	OXSR1	1.39126937
26	DYRK3	1.38718712
27	STK38	1.34710337
28	FRK	1.34064650
29	MARK3	1.25819215
30	CDK8	1.24673616
31	PTK2B	1.24327513
32	MAP3K4	1.11761933
33	MET	1.09430567
34	BRSK1	1.05801061
35	STK16	1.02554421
36	WNK4	1.01966367
37	MST4	1.01564423
38	CDK7	0.95046428
39	PRKCI	0.93135940
40	CHEK2	0.89438539
41	TLK1	0.85684314
42	MELK	0.83186368
43	DAPK1	0.80359835
44	STK39	0.79764656
45	CAMK1	0.78600806
46	CAMKK2	0.78152495
47	BCKDK	0.78040495
48	STK11	0.76216486
49	AURKA	0.75029575
50	CDK9	0.73675651
51	CAMK1D	0.71835047
52	TYRO3	0.71770120
53	CDC7	0.62024244
54	PLK1	0.59566202
55	RPS6KA5	0.59351747
56	DYRK1B	0.59234649
57	MAP2K7	0.57468562
58	PDK2	0.56568467
59	MST1R	0.55895940
60	CASK	0.55792416
61	PDK1	0.55245508
62	SRPK1	0.54228659
63	PLK3	0.53699975
64	PDPK1	0.53699150
65	ATR	0.53585140
66	CHEK1	0.50145747
67	NEK1	0.48741117
68	BLK	0.46883766
69	TTK	0.44436103
70	BMX	0.44156837
71	PIK3CG	0.43431042
72	PBK	0.43168330
73	EPHA2	0.42700487
74	ARAF	0.42218254
75	FLT3	0.40928834
76	MAP4K2	0.40905913
77	DAPK3	0.39945283
78	DDR2	0.38498801
79	GRK1	0.38253633
80	ADRBK2	0.36433932
81	LIMK1	0.34939180
82	CAMK4	0.34455277
83	NEK6	0.31512668
84	CSF1R	0.31300010
85	MAP3K9	0.29313736
86	NEK2	0.28890409
87	ABL2	0.28417161
88	EIF2AK2	0.26593143
89	PRKG2	0.26192596
90	DYRK1A	0.25965200
91	CDK14	0.24276730
92	NME1	0.24097363
93	KDR	0.23662720
94	CSNK1E	0.23578700
95	TIE1	0.22837229
96	CDK11A	0.22478366
97	CSNK2A1	0.22452128
98	ATM	0.22306967
99	CSNK1A1	0.22218426
100	MAP3K11	0.21647295

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mismatch repair_Homo sapiens_hsa03430	3.06211711
2	Base excision repair_Homo sapiens_hsa03410	2.89831128
3	DNA replication_Homo sapiens_hsa03030	2.81558260
4	Propanoate metabolism_Homo sapiens_hsa00640	2.70813497
5	Sulfur relay system_Homo sapiens_hsa04122	2.62233657
6	Proteasome_Homo sapiens_hsa03050	2.60209762
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.52863596
8	Homologous recombination_Homo sapiens_hsa03440	2.37655624
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.26533265
10	Ribosome_Homo sapiens_hsa03010	2.15111233
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.04860367
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.01929358
13	Huntingtons disease_Homo sapiens_hsa05016	2.00702532
14	Basal transcription factors_Homo sapiens_hsa03022	1.92462244
15	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.89399958
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.86311593
17	One carbon pool by folate_Homo sapiens_hsa00670	1.83984444
18	Parkinsons disease_Homo sapiens_hsa05012	1.77992308
19	Regulation of autophagy_Homo sapiens_hsa04140	1.77099207
20	RNA transport_Homo sapiens_hsa03013	1.72461117
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.68102712
22	Olfactory transduction_Homo sapiens_hsa04740	1.66566142
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.59944008
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.58599387
25	Fatty acid degradation_Homo sapiens_hsa00071	1.50327434
26	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.43862325
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.42494326
28	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.38514424
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.38119313
30	Butanoate metabolism_Homo sapiens_hsa00650	1.33110126
31	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.31335215
32	RNA degradation_Homo sapiens_hsa03018	1.27102818
33	Phenylalanine metabolism_Homo sapiens_hsa00360	1.24864000
34	RNA polymerase_Homo sapiens_hsa03020	1.23085600
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22417143
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17372059
37	Fatty acid metabolism_Homo sapiens_hsa01212	1.16849186
38	Glutathione metabolism_Homo sapiens_hsa00480	1.15238349
39	Purine metabolism_Homo sapiens_hsa00230	1.14365730
40	Carbon metabolism_Homo sapiens_hsa01200	1.12506423
41	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.12213851
42	beta-Alanine metabolism_Homo sapiens_hsa00410	1.08326278
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03397103
44	Cell cycle_Homo sapiens_hsa04110	1.02649681
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.02545921
46	mRNA surveillance pathway_Homo sapiens_hsa03015	1.00856064
47	Phototransduction_Homo sapiens_hsa04744	0.99639850
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.99565883
49	Alzheimers disease_Homo sapiens_hsa05010	0.96907553
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.96151815
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95908008
52	Retinol metabolism_Homo sapiens_hsa00830	0.95803366
53	Metabolic pathways_Homo sapiens_hsa01100	0.94177364
54	Non-homologous end-joining_Homo sapiens_hsa03450	0.93442207
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.92431498
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.90487907
57	Nitrogen metabolism_Homo sapiens_hsa00910	0.89602513
58	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.88452447
59	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.87067703
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.87059425
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.86790172
62	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.85682106
63	Peroxisome_Homo sapiens_hsa04146	0.85607339
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.85385268
65	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.83580525
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.83384411
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.82136798
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81281675
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79464105
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.79125948
71	Tyrosine metabolism_Homo sapiens_hsa00350	0.78016731
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73501650
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.73092993
74	Folate biosynthesis_Homo sapiens_hsa00790	0.72122484
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.70500593
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69716664
77	Arginine biosynthesis_Homo sapiens_hsa00220	0.67612669
78	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.65220917
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64853148
80	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.63427389
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63396271
82	Oocyte meiosis_Homo sapiens_hsa04114	0.63142103
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.60778516
84	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60408401
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59109433
86	p53 signaling pathway_Homo sapiens_hsa04115	0.59093644
87	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58985413
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57516846
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.54802028
90	Fatty acid elongation_Homo sapiens_hsa00062	0.52554577
91	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50475610
92	Sulfur metabolism_Homo sapiens_hsa00920	0.49514489
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45499256
94	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.42352330
95	Nicotine addiction_Homo sapiens_hsa05033	0.40934263
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37825835
97	Taste transduction_Homo sapiens_hsa04742	0.37333495
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33951868
99	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.32704167
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.29372674

KRT18P55

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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