KRT18P57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1germinal center formation (GO:0002467)5.46547861
2negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.93441499
3negative regulation of T-helper cell differentiation (GO:0045623)4.93441499
4positive regulation of gamma-delta T cell activation (GO:0046645)4.51999088
5hepatocyte apoptotic process (GO:0097284)4.48260293
6regulation of B cell receptor signaling pathway (GO:0050855)4.44421039
7histone H3-K4 trimethylation (GO:0080182)4.38534433
8negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.28549322
9growth hormone receptor signaling pathway (GO:0060396)4.26248032
10monoubiquitinated protein deubiquitination (GO:0035520)4.25266920
11negative regulation of B cell mediated immunity (GO:0002713)4.00367224
12negative regulation of immunoglobulin mediated immune response (GO:0002890)4.00367224
13cellular response to ethanol (GO:0071361)3.97414639
14myeloid leukocyte mediated immunity (GO:0002444)3.93528379
15neutrophil activation involved in immune response (GO:0002283)3.91836323
16cellular extravasation (GO:0045123)3.90469627
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.88419481
18positive regulation of granulocyte differentiation (GO:0030854)3.87719614
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85006600
20protein K11-linked deubiquitination (GO:0035871)3.77940070
21cellular response to growth hormone stimulus (GO:0071378)3.77393029
22regulation of interleukin-12 biosynthetic process (GO:0045075)3.74186059
23regulation of memory T cell differentiation (GO:0043380)3.71887453
24phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.69927516
25regulation of germinal center formation (GO:0002634)3.68779585
26positive regulation of developmental pigmentation (GO:0048087)3.66621489
27protein K48-linked deubiquitination (GO:0071108)3.65013221
28detection of molecule of bacterial origin (GO:0032490)3.61378055
29negative regulation of Rho protein signal transduction (GO:0035024)3.58306751
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50337363
31regulation of hypersensitivity (GO:0002883)3.47885426
32definitive hemopoiesis (GO:0060216)3.45110588
33histone H3-K36 demethylation (GO:0070544)3.44927547
34B cell receptor signaling pathway (GO:0050853)3.42286889
35peptidyl-lysine trimethylation (GO:0018023)3.40191847
36regulation of MHC class I biosynthetic process (GO:0045343)3.38786971
37regulation of pigment cell differentiation (GO:0050932)3.35484484
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.33829204
39negative regulation of translation, ncRNA-mediated (GO:0040033)3.33829204
40regulation of translation, ncRNA-mediated (GO:0045974)3.33829204
41necrotic cell death (GO:0070265)3.31028328
42negative T cell selection (GO:0043383)3.30874882
43protein K63-linked deubiquitination (GO:0070536)3.26595554
44antigen processing and presentation of endogenous antigen (GO:0019883)3.25241141
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.20107694
46regulation of gamma-delta T cell differentiation (GO:0045586)3.18798884
47regulation of gamma-delta T cell activation (GO:0046643)3.17836551
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.15577781
49negative thymic T cell selection (GO:0045060)3.12001577
50negative regulation of alpha-beta T cell differentiation (GO:0046639)3.10682859
51peptidyl-lysine methylation (GO:0018022)3.10264662
52negative regulation of lymphocyte mediated immunity (GO:0002707)3.10078031
53neutrophil mediated immunity (GO:0002446)3.02446070
54positive regulation by symbiont of host defense response (GO:0052509)3.00928322
55modulation by symbiont of host defense response (GO:0052031)3.00928322
56modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00928322
57modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00928322
58positive regulation by organism of defense response of other organism involved in symbiotic interact3.00928322
59modulation by symbiont of host immune response (GO:0052553)3.00928322
60embryonic process involved in female pregnancy (GO:0060136)3.00926962
61regulation of alpha-beta T cell proliferation (GO:0046640)2.99293257
62cell wall macromolecule catabolic process (GO:0016998)2.99252630
63positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.98276091
64negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.97832578
65negative regulation of cell killing (GO:0031342)2.97832578
66negative regulation of type 2 immune response (GO:0002829)2.96852664
67corticosteroid receptor signaling pathway (GO:0031958)2.95775239
68histone H3-K4 methylation (GO:0051568)2.95509362
69positive regulation of alpha-beta T cell proliferation (GO:0046641)2.95408738
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93559244
71myeloid cell activation involved in immune response (GO:0002275)2.90197521
72macrophage activation (GO:0042116)2.90087376
73macrophage activation involved in immune response (GO:0002281)2.89861490
74regulation of establishment of cell polarity (GO:2000114)2.89390821
75regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.89290854
76neutrophil activation (GO:0042119)2.88578848
77negative regulation of interleukin-12 production (GO:0032695)2.88431388
78regulation of viral entry into host cell (GO:0046596)2.86187783
79programmed necrotic cell death (GO:0097300)2.86035920
80T cell migration (GO:0072678)2.82565610
81innate immune response in mucosa (GO:0002227)2.81805899
82positive T cell selection (GO:0043368)2.81259897
83phospholipid translocation (GO:0045332)2.81142004
84lipid translocation (GO:0034204)2.81142004
85cytoplasmic mRNA processing body assembly (GO:0033962)2.80656140
86negative regulation of DNA recombination (GO:0045910)2.77472596
87pericardium development (GO:0060039)2.77383215
88iron ion import (GO:0097286)2.75829050
89negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.73561222
90glucocorticoid receptor signaling pathway (GO:0042921)2.72550929
91regulation of T-helper 2 cell differentiation (GO:0045628)2.71944299
92microglial cell activation (GO:0001774)2.71106057
93negative regulation of viral entry into host cell (GO:0046597)2.70801837
94detection of external biotic stimulus (GO:0098581)2.70642038
95negative regulation of DNA repair (GO:0045738)2.69472160
96negative regulation of B cell proliferation (GO:0030889)2.66281204
97histone mRNA catabolic process (GO:0071044)2.63767976
98oocyte development (GO:0048599)2.62402283
99regulation of T-helper 1 cell differentiation (GO:0045625)2.61417174
100natural killer cell activation involved in immune response (GO:0002323)2.60042842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.65798570
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.15126593
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.09573106
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.27131009
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.17148797
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.09590827
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70144042
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.50773009
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.40972481
10SCL_19346495_ChIP-Seq_HPC-7_Human2.35907336
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35011296
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.30864966
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29357912
14MYB_26560356_Chip-Seq_TH2_Human2.27322868
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23024695
16RUNX_20019798_ChIP-Seq_JUKART_Human2.20043921
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17471367
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.13391115
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10136816
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.07892423
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.04243811
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99372311
23TP53_16413492_ChIP-PET_HCT116_Human1.94974462
24VDR_24787735_ChIP-Seq_THP-1_Human1.93193806
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91550088
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91294857
27GATA3_27048872_Chip-Seq_THYMUS_Human1.88970121
28RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.83871269
29CIITA_25753668_ChIP-Seq_RAJI_Human1.81360650
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80346039
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76170129
32ZNF274_21170338_ChIP-Seq_K562_Hela1.75292764
33SPI1_23127762_ChIP-Seq_K562_Human1.70617383
34MYB_26560356_Chip-Seq_TH1_Human1.68151546
35GATA3_26560356_Chip-Seq_TH2_Human1.67539236
36SPI1_23547873_ChIP-Seq_NB4_Human1.65044578
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60332611
38GATA1_22025678_ChIP-Seq_K562_Human1.56278920
39VDR_24763502_ChIP-Seq_THP-1_Human1.54388738
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53798019
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.53332732
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53320187
43NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.53143956
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51475541
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49846923
46GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46668151
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.44914993
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.43129258
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40677981
50GATA1_19941826_ChIP-Seq_K562_Human1.35913624
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35886593
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.35497356
53IRF1_19129219_ChIP-ChIP_H3396_Human1.34132032
54MAF_26560356_Chip-Seq_TH1_Human1.31665490
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25839417
56VDR_23849224_ChIP-Seq_CD4+_Human1.23211819
57KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19316918
58AHR_22903824_ChIP-Seq_MCF-7_Human1.17891528
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.16965497
60BRD4_25478319_ChIP-Seq_HGPS_Human1.15800386
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14513769
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14513769
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13508220
64GATA2_19941826_ChIP-Seq_K562_Human1.10679825
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.09674037
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09508589
67PU_27001747_Chip-Seq_BMDM_Mouse1.09193943
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08921944
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08751270
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08602559
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07350638
72JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06352764
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05970670
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.05554516
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04007572
76TAF15_26573619_Chip-Seq_HEK293_Human1.01821194
77SMRT_27268052_Chip-Seq_Bcells_Human1.01146820
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98524570
79GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97458354
80PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97419411
81ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96894610
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96528214
83EWS_26573619_Chip-Seq_HEK293_Human0.96324324
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94795472
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93826947
86RUNX1_22412390_ChIP-Seq_EML_Mouse0.93764141
87SALL4_22934838_ChIP-ChIP_CD34+_Human0.92874904
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92581803
89TFEB_21752829_ChIP-Seq_HELA_Human0.90331070
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88950055
91FLI1_21867929_ChIP-Seq_TH2_Mouse0.88848665
92CBP_20019798_ChIP-Seq_JUKART_Human0.88573375
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88573375
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87683137
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87683137
96ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87404681
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84908008
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83985980
99STAT3_23295773_ChIP-Seq_U87_Human0.82845263
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82844239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.13312210
2MP0002138_abnormal_hepatobiliary_system3.93699935
3MP0004381_abnormal_hair_follicle3.92391452
4MP0000569_abnormal_digit_pigmentation3.76096298
5MP0001835_abnormal_antigen_presentation3.26601543
6MP0003763_abnormal_thymus_physiology3.02829434
7MP0005075_abnormal_melanosome_morpholog2.92931835
8MP0002166_altered_tumor_susceptibility2.82263657
9MP0000685_abnormal_immune_system2.46342608
10MP0001853_heart_inflammation2.44968811
11MP0001800_abnormal_humoral_immune2.33541167
12MP0002396_abnormal_hematopoietic_system2.29160031
13MP0003828_pulmonary_edema2.14831160
14MP0010352_gastrointestinal_tract_polyps1.98195222
15MP0002006_tumorigenesis1.97595906
16MP0005167_abnormal_blood-brain_barrier1.87333615
17MP0003724_increased_susceptibility_to1.81808201
18MP0002405_respiratory_system_inflammati1.81669232
19MP0006054_spinal_hemorrhage1.78063441
20MP0002419_abnormal_innate_immunity1.75888799
21MP0002452_abnormal_antigen_presenting1.73303300
22MP0002420_abnormal_adaptive_immunity1.69048334
23MP0004808_abnormal_hematopoietic_stem1.68907478
24MP0001819_abnormal_immune_cell1.65664787
25MP0002723_abnormal_immune_serum1.63822339
26MP0009785_altered_susceptibility_to1.62239024
27MP0003866_abnormal_defecation1.60722161
28MP0002398_abnormal_bone_marrow1.60323713
29MP0000716_abnormal_immune_system1.52225446
30MP0005310_abnormal_salivary_gland1.51991276
31MP0001790_abnormal_immune_system1.50654322
32MP0005387_immune_system_phenotype1.50654322
33MP0008961_abnormal_basal_metabolism1.49508141
34MP0000689_abnormal_spleen_morphology1.46299018
35MP0005025_abnormal_response_to1.44444309
36MP0003045_fibrosis1.44416600
37MP0000703_abnormal_thymus_morphology1.43375386
38MP0004947_skin_inflammation1.43256409
39MP0003436_decreased_susceptibility_to1.42227965
40MP0005000_abnormal_immune_tolerance1.40336707
41MP0003172_abnormal_lysosome_physiology1.37338303
42MP0002722_abnormal_immune_system1.36947290
43MP0000015_abnormal_ear_pigmentation1.33511499
44MP0000427_abnormal_hair_cycle1.33353357
45MP0005076_abnormal_cell_differentiation1.29358484
46MP0004147_increased_porphyrin_level1.29158055
47MP0003091_abnormal_cell_migration1.29118577
48MP0003300_gastrointestinal_ulcer1.28427912
49MP0003303_peritoneal_inflammation1.27369599
50MP0004130_abnormal_muscle_cell1.24374894
51MP0001873_stomach_inflammation1.24308758
52MP0003786_premature_aging1.21814110
53MP0002429_abnormal_blood_cell1.19736171
54MP0003195_calcinosis1.16486585
55MP0002009_preneoplasia1.16353817
56MP0005671_abnormal_response_to1.14322995
57MP0005174_abnormal_tail_pigmentation1.13634064
58MP0009764_decreased_sensitivity_to1.12113570
59MP0002254_reproductive_system_inflammat1.11201365
60MP0001545_abnormal_hematopoietic_system1.10655227
61MP0005397_hematopoietic_system_phenotyp1.10655227
62MP0006082_CNS_inflammation1.10455394
63MP0002148_abnormal_hypersensitivity_rea1.08800259
64MP0001845_abnormal_inflammatory_respons1.01641991
65MP0000647_abnormal_sebaceous_gland0.99046081
66MP0009115_abnormal_fat_cell0.98947603
67MP0004484_altered_response_of0.93156198
68MP0002168_other_aberrant_phenotype0.89748971
69MP0002638_abnormal_pupillary_reflex0.89203420
70MP0009333_abnormal_splenocyte_physiolog0.87707260
71MP0000371_diluted_coat_color0.87431214
72MP0008995_early_reproductive_senescence0.86291045
73MP0005464_abnormal_platelet_physiology0.85753417
74MP0003646_muscle_fatigue0.85749331
75MP0005266_abnormal_metabolism0.85618702
76MP0002019_abnormal_tumor_incidence0.85361023
77MP0002998_abnormal_bone_remodeling0.84286316
78MP0002277_abnormal_respiratory_mucosa0.84133122
79MP0002332_abnormal_exercise_endurance0.81872937
80MP0008260_abnormal_autophagy0.80469982
81MP0004883_abnormal_blood_vessel0.79916969
82MP0003656_abnormal_erythrocyte_physiolo0.76549851
83MP0000372_irregular_coat_pigmentation0.76443459
84MP0001851_eye_inflammation0.75993504
85MP0005220_abnormal_exocrine_pancreas0.74142893
86MP0010155_abnormal_intestine_physiology0.73214366
87MP0003221_abnormal_cardiomyocyte_apopto0.69639898
88MP0005376_homeostasis/metabolism_phenot0.68121297
89MP0009697_abnormal_copulation0.67997953
90MP0005621_abnormal_cell_physiology0.67833179
91MP0008875_abnormal_xenobiotic_pharmacok0.67548440
92MP0003984_embryonic_growth_retardation0.66997099
93MP0002088_abnormal_embryonic_growth/wei0.66642906
94MP0002928_abnormal_bile_duct0.66600447
95MP0001542_abnormal_bone_strength0.64533966
96MP0000249_abnormal_blood_vessel0.62475988
97MP0006035_abnormal_mitochondrial_morpho0.61112343
98MP0005164_abnormal_response_to0.60628598
99MP0003252_abnormal_bile_duct0.57829913
100MP0008873_increased_physiological_sensi0.57238272

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.91987463
2Abnormality of the fingertips (HP:0001211)6.30639541
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.34287895
4Abnormality of alanine metabolism (HP:0010916)4.34287895
5Hyperalaninemia (HP:0003348)4.34287895
6Prominent nose (HP:0000448)3.56551796
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.53144208
8Abnormality of T cell number (HP:0011839)3.52975464
9T lymphocytopenia (HP:0005403)3.48847916
10Genetic anticipation (HP:0003743)3.31702481
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.29320861
12Mediastinal lymphadenopathy (HP:0100721)3.10324757
13Chronic hepatic failure (HP:0100626)3.07164978
14Amyloidosis (HP:0011034)3.05498432
15Clubbing of toes (HP:0100760)3.04859682
16Chronic mucocutaneous candidiasis (HP:0002728)3.00542367
17Recurrent cutaneous fungal infections (HP:0011370)3.00542367
18Recurrent fungal infections (HP:0002841)3.00443964
19Large eyes (HP:0001090)2.97348449
20Recurrent bronchitis (HP:0002837)2.90307347
21Stomatitis (HP:0010280)2.85584537
22Reduced subcutaneous adipose tissue (HP:0003758)2.80598153
23Clumsiness (HP:0002312)2.77637284
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.72919781
25IgA deficiency (HP:0002720)2.72347719
26Colitis (HP:0002583)2.60778143
27Abnormality of the peritoneum (HP:0002585)2.54663539
28Autoimmune hemolytic anemia (HP:0001890)2.54338909
29Recurrent bacterial skin infections (HP:0005406)2.52752783
30Fair hair (HP:0002286)2.52541193
31Increased neuronal autofluorescent lipopigment (HP:0002074)2.49732249
32Birth length less than 3rd percentile (HP:0003561)2.49624530
33Optic neuritis (HP:0100653)2.44866838
34Retrobulbar optic neuritis (HP:0100654)2.44866838
35Chronic otitis media (HP:0000389)2.43776146
36Microcytic anemia (HP:0001935)2.43343123
37IgM deficiency (HP:0002850)2.43295776
38Macroglossia (HP:0000158)2.43243777
39Papillary thyroid carcinoma (HP:0002895)2.43067919
40Postural instability (HP:0002172)2.40547852
41Myositis (HP:0100614)2.39675141
42Abnormality of T cells (HP:0002843)2.39535894
43Orchitis (HP:0100796)2.36443468
44Hypochromic microcytic anemia (HP:0004840)2.36226281
45Widely spaced teeth (HP:0000687)2.33288680
46Narrow palate (HP:0000189)2.29490522
47Sparse lateral eyebrow (HP:0005338)2.28520195
48Slow saccadic eye movements (HP:0000514)2.28361280
49Acute myeloid leukemia (HP:0004808)2.27772573
50Autoimmune thrombocytopenia (HP:0001973)2.26920616
51Leukocytosis (HP:0001974)2.26014897
52Recurrent abscess formation (HP:0002722)2.25859674
53Long eyelashes (HP:0000527)2.24723627
54Eosinophilia (HP:0001880)2.23518168
55Encephalitis (HP:0002383)2.19546793
56Protruding tongue (HP:0010808)2.19423806
57Abnormal glucose tolerance (HP:0001952)2.16385827
58Submucous cleft hard palate (HP:0000176)2.15716370
59Eczematoid dermatitis (HP:0000976)2.14529021
60Meningitis (HP:0001287)2.13841918
61Gaze-evoked nystagmus (HP:0000640)2.11228209
62Subacute progressive viral hepatitis (HP:0006572)2.07772915
63Spontaneous hematomas (HP:0007420)2.06060275
64Bicuspid aortic valve (HP:0001647)2.05256191
65Recurrent viral infections (HP:0004429)2.04115057
66Generalized hypopigmentation of hair (HP:0011358)2.03556194
67Basal ganglia calcification (HP:0002135)2.03381717
68Vasculitis (HP:0002633)2.02949923
69Lip pit (HP:0100267)2.00949097
70Chest pain (HP:0100749)2.00572724
71Increased cerebral lipofuscin (HP:0011813)1.99484612
72Abnormality of eosinophils (HP:0001879)1.99353803
73Abnormal hair whorl (HP:0010721)1.99043685
74Micronodular cirrhosis (HP:0001413)1.98718038
75Tubulointerstitial nephritis (HP:0001970)1.95406300
76Facial diplegia (HP:0001349)1.93744539
77Recurrent skin infections (HP:0001581)1.92686118
78Viral hepatitis (HP:0006562)1.92647683
79Hematochezia (HP:0002573)1.92521299
80Febrile seizures (HP:0002373)1.91002617
81Hypoplastic iliac wings (HP:0002866)1.90317407
82Abnormality of T cell physiology (HP:0011840)1.89636202
83Inflammation of the large intestine (HP:0002037)1.89090640
84Abnormality of the pleura (HP:0002103)1.89031689
85Granulocytopenia (HP:0001913)1.88828186
86Neonatal hypoglycemia (HP:0001998)1.83810118
87Fatigue (HP:0012378)1.83354011
88Abnormality of the columella (HP:0009929)1.82457484
89Ileus (HP:0002595)1.80488242
90Chronic diarrhea (HP:0002028)1.80218943
91Abnormal spermatogenesis (HP:0008669)1.79911481
92Abnormality of the vasculature of the conjunctiva (HP:0008054)1.78735154
93Gastrointestinal infarctions (HP:0005244)1.77946960
94Acute lymphatic leukemia (HP:0006721)1.76539266
95Hyperventilation (HP:0002883)1.76427801
96Thyroiditis (HP:0100646)1.76273942
97Stomach cancer (HP:0012126)1.76029559
98Short chin (HP:0000331)1.75398873
99Atonic seizures (HP:0010819)1.73254321
100Arterial thrombosis (HP:0004420)1.71763307

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.21120347
2AKT34.76122432
3ACVR1B2.76935216
4PIK3CG2.16298233
5BLK2.11851344
6CAMK1D2.10922466
7BRD42.09219520
8NLK2.01221256
9MAP3K61.97637886
10CDK121.95763642
11CHUK1.93794005
12IKBKE1.85121145
13TXK1.76672991
14MARK31.75170277
15MELK1.73840335
16MAP2K31.73181554
17MKNK21.70004412
18IRAK11.63432593
19MAP3K141.61986709
20TAOK31.59267801
21MAP3K21.58430764
22IKBKB1.54039825
23MAP3K51.48224012
24TRPM71.45066126
25MAP4K11.43586361
26TEC1.40360903
27BTK1.39608461
28PIM11.36195292
29SGK21.33068558
30WNK11.32716642
31RIPK41.28149228
32TYK21.23699084
33CAMK1G1.18941854
34CAMKK21.16011381
35BMPR1B1.13930514
36MAP3K131.13051690
37JAK11.12408494
38SYK1.09671487
39PIK3CA1.02849640
40OXSR11.02075718
41FGFR31.02063943
42MAPK111.00769583
43ZAP700.99914894
44CSK0.99400693
45STK40.98300200
46NUAK10.94655113
47SGK30.89438210
48LATS10.89351549
49HCK0.88248598
50JAK20.86026963
51ITK0.85279342
52MAP3K70.82849647
53CAMK40.80440950
54PTK2B0.77962370
55IRAK40.77662142
56CDK60.75810570
57JAK30.75553939
58STK110.73819282
59IRAK20.70022218
60CAMK10.67327308
61RAF10.66696509
62RPS6KB20.66263970
63LCK0.65739665
64MARK20.65070734
65FES0.63505209
66PKN20.62282624
67GRK60.61297423
68SIK20.58844374
69RPS6KA50.57956332
70LYN0.56460372
71ZAK0.55706807
72TLK10.55390989
73SGK2230.53066428
74SGK4940.53066428
75PDK20.53049674
76PDK10.51420252
77PDGFRB0.50500114
78BMPR20.49717479
79NEK60.49363406
80FER0.49055764
81PRKAA10.48643168
82ATR0.48462965
83PRKAA20.47320423
84MKNK10.46653288
85KSR10.46136851
86PRKCQ0.46049392
87MAP3K10.45608491
88YES10.43732744
89EPHB10.43535327
90EGFR0.42717616
91BRSK20.41246129
92NEK90.40752132
93MAP4K20.39951246
94CSNK1A1L0.38310394
95DYRK1A0.37335848
96RET0.36883755
97HIPK20.36864658
98INSRR0.36733719
99STK100.36588170
100SGK10.36533140

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.92811984
2Viral carcinogenesis_Homo sapiens_hsa052032.48714491
3Alcoholism_Homo sapiens_hsa050342.34993214
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.12626794
5Osteoclast differentiation_Homo sapiens_hsa043802.08725053
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.99220831
7NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77852639
8B cell receptor signaling pathway_Homo sapiens_hsa046621.75387676
9Leishmaniasis_Homo sapiens_hsa051401.71970697
10Graft-versus-host disease_Homo sapiens_hsa053321.71560102
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69177229
12Staphylococcus aureus infection_Homo sapiens_hsa051501.68858233
13Primary immunodeficiency_Homo sapiens_hsa053401.65434012
14T cell receptor signaling pathway_Homo sapiens_hsa046601.62577949
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.55489723
16Acute myeloid leukemia_Homo sapiens_hsa052211.54898972
17Measles_Homo sapiens_hsa051621.54331406
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.52205152
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51884607
20TNF signaling pathway_Homo sapiens_hsa046681.49592475
21FoxO signaling pathway_Homo sapiens_hsa040681.48603851
22Dorso-ventral axis formation_Homo sapiens_hsa043201.47706954
23Allograft rejection_Homo sapiens_hsa053301.46215898
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44508614
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42482283
26Autoimmune thyroid disease_Homo sapiens_hsa053201.42361158
27Tuberculosis_Homo sapiens_hsa051521.42309174
28Prolactin signaling pathway_Homo sapiens_hsa049171.36450115
29Influenza A_Homo sapiens_hsa051641.36027452
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33832823
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32182063
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29732521
33Non-small cell lung cancer_Homo sapiens_hsa052231.29221534
34Herpes simplex infection_Homo sapiens_hsa051681.26874605
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22055253
36Toxoplasmosis_Homo sapiens_hsa051451.21810238
37Pancreatic cancer_Homo sapiens_hsa052121.21274912
38Hepatitis B_Homo sapiens_hsa051611.20859090
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.20265939
40Legionellosis_Homo sapiens_hsa051341.18208796
41p53 signaling pathway_Homo sapiens_hsa041151.17330432
42Epstein-Barr virus infection_Homo sapiens_hsa051691.14982296
43Lysine degradation_Homo sapiens_hsa003101.12758047
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11628520
45Circadian rhythm_Homo sapiens_hsa047101.08469742
46Platelet activation_Homo sapiens_hsa046111.08413678
47Chronic myeloid leukemia_Homo sapiens_hsa052201.08029219
48Endometrial cancer_Homo sapiens_hsa052131.06722888
49Colorectal cancer_Homo sapiens_hsa052101.06599769
50Apoptosis_Homo sapiens_hsa042101.04098510
51Hepatitis C_Homo sapiens_hsa051601.03779982
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02264744
53Inositol phosphate metabolism_Homo sapiens_hsa005621.00811745
54Prostate cancer_Homo sapiens_hsa052150.99016471
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88408459
56Hematopoietic cell lineage_Homo sapiens_hsa046400.87578877
57ABC transporters_Homo sapiens_hsa020100.85481031
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85359365
59Type I diabetes mellitus_Homo sapiens_hsa049400.84454971
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.82469630
61Malaria_Homo sapiens_hsa051440.81940312
62Chemokine signaling pathway_Homo sapiens_hsa040620.78929516
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.78732534
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78198213
65Choline metabolism in cancer_Homo sapiens_hsa052310.77169974
66Taste transduction_Homo sapiens_hsa047420.75453039
67Renal cell carcinoma_Homo sapiens_hsa052110.74962725
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72194032
69Fanconi anemia pathway_Homo sapiens_hsa034600.70441886
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.69878050
71Viral myocarditis_Homo sapiens_hsa054160.65356045
72Antigen processing and presentation_Homo sapiens_hsa046120.65329985
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65109754
74Type II diabetes mellitus_Homo sapiens_hsa049300.64685212
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64563940
76Small cell lung cancer_Homo sapiens_hsa052220.63763321
77ErbB signaling pathway_Homo sapiens_hsa040120.62615135
78HIF-1 signaling pathway_Homo sapiens_hsa040660.60534887
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.59429597
80Insulin resistance_Homo sapiens_hsa049310.59394451
81Nitrogen metabolism_Homo sapiens_hsa009100.58038105
82MAPK signaling pathway_Homo sapiens_hsa040100.57744132
83HTLV-I infection_Homo sapiens_hsa051660.55000613
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53271949
85MicroRNAs in cancer_Homo sapiens_hsa052060.52021518
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51518400
87RNA polymerase_Homo sapiens_hsa030200.49879116
88mRNA surveillance pathway_Homo sapiens_hsa030150.49299941
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48884234
90Homologous recombination_Homo sapiens_hsa034400.48493582
91mTOR signaling pathway_Homo sapiens_hsa041500.48080889
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47503032
93Non-homologous end-joining_Homo sapiens_hsa034500.43257451
94Thyroid cancer_Homo sapiens_hsa052160.43253110
95Asthma_Homo sapiens_hsa053100.42567798
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42373883
97Propanoate metabolism_Homo sapiens_hsa006400.42218131
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39079797
99TGF-beta signaling pathway_Homo sapiens_hsa043500.38963825
100VEGF signaling pathway_Homo sapiens_hsa043700.38036237

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