ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	6.84280065
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.22692868
3	chaperone-mediated protein transport (GO:0072321)	5.61870846
4	signal peptide processing (GO:0006465)	5.49794097
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.40220229
6	protein neddylation (GO:0045116)	4.91780772
7	regulation of mitochondrial translation (GO:0070129)	4.79824914
8	cytochrome complex assembly (GO:0017004)	4.73746172
9	ATP synthesis coupled proton transport (GO:0015986)	4.71228454
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.71228454
11	protein complex biogenesis (GO:0070271)	4.49325442
12	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.46201859
13	regulation of cellular amino acid metabolic process (GO:0006521)	4.44238071
14	mitochondrial respiratory chain complex assembly (GO:0033108)	4.33255107
15	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	4.31094886
16	respiratory chain complex IV assembly (GO:0008535)	4.27296422
17	polyketide metabolic process (GO:0030638)	4.22019570
18	doxorubicin metabolic process (GO:0044598)	4.22019570
19	daunorubicin metabolic process (GO:0044597)	4.22019570
20	DNA deamination (GO:0045006)	4.20639051
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.18634869
22	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	4.12467258
23	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	4.11772803
24	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.07862711
25	termination of RNA polymerase III transcription (GO:0006386)	4.07862711
26	negative regulation of ligase activity (GO:0051352)	4.06600664
27	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	4.06600664
28	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	4.01258733
29	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	4.01258733
30	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	4.00823000
31	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	4.00823000
32	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	4.00823000
33	water-soluble vitamin biosynthetic process (GO:0042364)	3.95921730
34	respiratory electron transport chain (GO:0022904)	3.93245405
35	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.89064404
36	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.89064404
37	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.87536155
38	electron transport chain (GO:0022900)	3.86875811
39	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.83407663
40	aminoglycoside antibiotic metabolic process (GO:0030647)	3.73887393
41	inner mitochondrial membrane organization (GO:0007007)	3.64659919
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.64073845
43	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.64073845
44	NADH dehydrogenase complex assembly (GO:0010257)	3.64073845
45	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.63884991
46	regulation of mitotic spindle checkpoint (GO:1903504)	3.62126245
47	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.62126245
48	positive regulation of ligase activity (GO:0051351)	3.54951021
49	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.54264087
50	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	3.48549599
51	protein deneddylation (GO:0000338)	3.45638855
52	positive regulation of interleukin-8 secretion (GO:2000484)	3.45584143
53	rRNA modification (GO:0000154)	3.40269196
54	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.38930510
55	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.38930510
56	intracellular protein transmembrane import (GO:0044743)	3.30580036
57	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.29367898
58	protein-cofactor linkage (GO:0018065)	3.26709523
59	DNA damage response, detection of DNA damage (GO:0042769)	3.21379182
60	base-excision repair, AP site formation (GO:0006285)	3.20936980
61	regulation of cellular amine metabolic process (GO:0033238)	3.19450421
62	regulation of ubiquitin-protein transferase activity (GO:0051438)	3.16755365
63	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.15929329
64	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.14519293
65	regulation of ligase activity (GO:0051340)	3.11359634
66	negative regulation of T cell differentiation in thymus (GO:0033085)	3.11176846
67	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.09601655
68	glucuronate metabolic process (GO:0019585)	3.04336913
69	uronic acid metabolic process (GO:0006063)	3.04336913
70	positive regulation of cell cycle arrest (GO:0071158)	3.03523753
71	flavonoid metabolic process (GO:0009812)	3.01893266
72	phenylpropanoid metabolic process (GO:0009698)	2.99993734
73	metallo-sulfur cluster assembly (GO:0031163)	2.99462113
74	iron-sulfur cluster assembly (GO:0016226)	2.99462113
75	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.99273270
76	cobalamin metabolic process (GO:0009235)	2.98602103
77	ribosomal small subunit assembly (GO:0000028)	2.97543134
78	ATP biosynthetic process (GO:0006754)	2.90177310
79	L-ascorbic acid metabolic process (GO:0019852)	2.89756226
80	branched-chain amino acid catabolic process (GO:0009083)	2.87966225
81	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.86800381
82	signal transduction in response to DNA damage (GO:0042770)	2.86782389
83	positive regulation of prostaglandin secretion (GO:0032308)	2.86620479
84	translation (GO:0006412)	2.78972468
85	protein targeting to mitochondrion (GO:0006626)	2.77939516
86	primary alcohol catabolic process (GO:0034310)	2.77694947
87	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.74326247
88	nucleotide transmembrane transport (GO:1901679)	2.71790525
89	ribosomal large subunit biogenesis (GO:0042273)	2.71363978
90	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.70757062
91	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.68437293
92	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.67682164
93	mannosylation (GO:0097502)	2.67209423
94	protein localization to endoplasmic reticulum (GO:0070972)	2.67030746
95	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.66870960
96	protein targeting to ER (GO:0045047)	2.66843795
97	protein peptidyl-prolyl isomerization (GO:0000413)	2.66424559
98	cotranslational protein targeting to membrane (GO:0006613)	2.65830843
99	endothelial tube morphogenesis (GO:0061154)	2.65652047
100	morphogenesis of an endothelium (GO:0003159)	2.65652047

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	5.23480805
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.11349144
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.40446061
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.99536355
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.83924008
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.59019674
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.55491728
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.35603642
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.27024257
10	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.97831707
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.93778331
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.86537571
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.85998857
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.75383914
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.58262861
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.51942242
17	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.48874337
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.40593963
19	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.29542080
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.28839036
21	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.28426375
22	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.25621193
23	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.17590977
24	DCP1A_22483619_ChIP-Seq_HELA_Human	2.11526302
25	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.08492314
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.02708384
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.90095321
28	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.87299647
29	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.86496642
30	GABP_19822575_ChIP-Seq_HepG2_Human	1.78411841
31	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.77341088
32	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.73194482
33	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.68624366
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.66012587
35	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.61899312
36	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.60146514
37	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.58637603
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54806436
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.54369364
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.54339833
41	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.53761464
42	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.51838984
43	XRN2_22483619_ChIP-Seq_HELA_Human	1.48470278
44	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.43621581
45	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.38092999
46	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.36299395
47	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.32142637
48	VDR_22108803_ChIP-Seq_LS180_Human	1.30832016
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29899673
50	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.28894540
51	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.27668932
52	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24438462
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22849599
54	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.22619909
55	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19655090
56	AR_20517297_ChIP-Seq_VCAP_Human	1.15599434
57	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.15490292
58	EWS_26573619_Chip-Seq_HEK293_Human	1.14667892
59	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12250387
60	TAF15_26573619_Chip-Seq_HEK293_Human	1.10321207
61	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.07807369
62	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.06505192
63	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.04018995
64	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03843920
65	FUS_26573619_Chip-Seq_HEK293_Human	1.03248948
66	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.02382756
67	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.01880741
68	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01734995
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01059001
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01059001
71	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.96924645
72	CIITA_25753668_ChIP-Seq_RAJI_Human	0.93462424
73	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.93054619
74	NCOR_22424771_ChIP-Seq_293T_Human	0.91862131
75	ELF5_23300383_ChIP-Seq_T47D_Human	0.88928119
76	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.88696122
77	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.88495694
78	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.85224193
79	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.82933620
80	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.82549730
81	SOX2_19829295_ChIP-Seq_ESCs_Human	0.82348766
82	NANOG_19829295_ChIP-Seq_ESCs_Human	0.82348766
83	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.82133414
84	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.82016511
85	KDM5A_27292631_Chip-Seq_BREAST_Human	0.81439080
86	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.81147088
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.81073221
88	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.80795146
89	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.79451543
90	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.78357756
91	TP53_22573176_ChIP-Seq_HFKS_Human	0.77847932
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.77262324
93	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.77054565
94	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.76279340
95	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.76170607
96	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.76016367
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.75850641
98	GATA4_25053715_ChIP-Seq_YYC3_Human	0.75726130
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.75598321
100	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.75058912

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.51812196
2	MP0003806_abnormal_nucleotide_metabolis	4.71654567
3	MP0001529_abnormal_vocalization	2.82476557
4	MP0002938_white_spotting	2.81896031
5	MP0002163_abnormal_gland_morphology	2.65135412
6	MP0000537_abnormal_urethra_morphology	2.61701417
7	MP0004133_heterotaxia	2.59983038
8	MP0006054_spinal_hemorrhage	2.52462308
9	MP0001666_abnormal_nutrient_absorption	2.51703887
10	MP0003693_abnormal_embryo_hatching	2.42156988
11	MP0006072_abnormal_retinal_apoptosis	2.29892332
12	MP0002638_abnormal_pupillary_reflex	2.16764653
13	MP0004957_abnormal_blastocyst_morpholog	2.07266171
14	MP0010030_abnormal_orbit_morphology	2.06428573
15	MP0001764_abnormal_homeostasis	2.05830937
16	MP0008877_abnormal_DNA_methylation	2.01336759
17	MP0008058_abnormal_DNA_repair	1.98260196
18	MP0000372_irregular_coat_pigmentation	1.93117635
19	MP0005671_abnormal_response_to	1.88838046
20	MP0003890_abnormal_embryonic-extraembry	1.86465823
21	MP0001293_anophthalmia	1.86345120
22	MP0004147_increased_porphyrin_level	1.84978627
23	MP0006036_abnormal_mitochondrial_physio	1.84587498
24	MP0003119_abnormal_digestive_system	1.83690430
25	MP0005085_abnormal_gallbladder_physiolo	1.82164845
26	MP0008875_abnormal_xenobiotic_pharmacok	1.81339870
27	MP0006035_abnormal_mitochondrial_morpho	1.79695366
28	MP0002277_abnormal_respiratory_mucosa	1.71693005
29	MP0003786_premature_aging	1.64836494
30	MP0003567_abnormal_fetal_cardiomyocyte	1.61096200
31	MP0003880_abnormal_central_pattern	1.51568981
32	MP0003718_maternal_effect	1.46015391
33	MP0001905_abnormal_dopamine_level	1.43513576
34	MP0002132_abnormal_respiratory_system	1.38509379
35	MP0010386_abnormal_urinary_bladder	1.37011033
36	MP0003077_abnormal_cell_cycle	1.36658964
37	MP0005367_renal/urinary_system_phenotyp	1.36059040
38	MP0000516_abnormal_urinary_system	1.36059040
39	MP0008789_abnormal_olfactory_epithelium	1.34679505
40	MP0002160_abnormal_reproductive_system	1.33565680
41	MP0005379_endocrine/exocrine_gland_phen	1.31967654
42	MP0008872_abnormal_physiological_respon	1.31278292
43	MP0002837_dystrophic_cardiac_calcinosis	1.26916972
44	MP0002102_abnormal_ear_morphology	1.25541257
45	MP0000049_abnormal_middle_ear	1.18122550
46	MP0005332_abnormal_amino_acid	1.16328692
47	MP0002234_abnormal_pharynx_morphology	1.14435468
48	MP0003122_maternal_imprinting	1.13876302
49	MP0005365_abnormal_bile_salt	1.09852814
50	MP0003186_abnormal_redox_activity	1.09685480
51	MP0000647_abnormal_sebaceous_gland	1.09317116
52	MP0004264_abnormal_extraembryonic_tissu	1.09228755
53	MP0004019_abnormal_vitamin_homeostasis	1.07587253
54	MP0009333_abnormal_splenocyte_physiolog	1.00430798
55	MP0010234_abnormal_vibrissa_follicle	0.99993431
56	MP0003111_abnormal_nucleus_morphology	0.99660020
57	MP0009765_abnormal_xenobiotic_induced	0.99376036
58	MP0002736_abnormal_nociception_after	0.97228281
59	MP0005646_abnormal_pituitary_gland	0.96221568
60	MP0001286_abnormal_eye_development	0.94281213
61	MP0000631_abnormal_neuroendocrine_gland	0.94233831
62	MP0003938_abnormal_ear_development	0.94079156
63	MP0009379_abnormal_foot_pigmentation	0.93965061
64	MP0005389_reproductive_system_phenotype	0.92358430
65	MP0003252_abnormal_bile_duct	0.89640363
66	MP0001119_abnormal_female_reproductive	0.87117891
67	MP0008932_abnormal_embryonic_tissue	0.86447104
68	MP0003646_muscle_fatigue	0.84159875
69	MP0003878_abnormal_ear_physiology	0.84105762
70	MP0005377_hearing/vestibular/ear_phenot	0.84105762
71	MP0001485_abnormal_pinna_reflex	0.79946786
72	MP0003137_abnormal_impulse_conducting	0.79696062
73	MP0003937_abnormal_limbs/digits/tail_de	0.79567406
74	MP0005408_hypopigmentation	0.79416893
75	MP0005636_abnormal_mineral_homeostasis	0.79009212
76	MP0005084_abnormal_gallbladder_morpholo	0.78672974
77	MP0003866_abnormal_defecation	0.77754138
78	MP0003121_genomic_imprinting	0.76830519
79	MP0003315_abnormal_perineum_morphology	0.75506722
80	MP0002233_abnormal_nose_morphology	0.74914566
81	MP0008873_increased_physiological_sensi	0.74828035
82	MP0008007_abnormal_cellular_replicative	0.74797878
83	MP0005670_abnormal_white_adipose	0.72382761
84	MP0010094_abnormal_chromosome_stability	0.72057837
85	MP0005253_abnormal_eye_physiology	0.71350427
86	MP0003763_abnormal_thymus_physiology	0.71147687
87	MP0005319_abnormal_enzyme/_coenzyme	0.70235381
88	MP0000538_abnormal_urinary_bladder	0.66370379
89	MP0002210_abnormal_sex_determination	0.65429610
90	MP0004134_abnormal_chest_morphology	0.63108337
91	MP0005075_abnormal_melanosome_morpholog	0.62973634
92	MP0000613_abnormal_salivary_gland	0.62787452
93	MP0001730_embryonic_growth_arrest	0.61317283
94	MP0008995_early_reproductive_senescence	0.61232564
95	MP0003195_calcinosis	0.60846513
96	MP0000428_abnormal_craniofacial_morphol	0.60615592
97	MP0005083_abnormal_biliary_tract	0.60434328
98	MP0000477_abnormal_intestine_morphology	0.58629996
99	MP0002084_abnormal_developmental_patter	0.58464151
100	MP0001756_abnormal_urination	0.57822081

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.00857072
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.55537300
3	Mitochondrial inheritance (HP:0001427)	4.44901381
4	Acute encephalopathy (HP:0006846)	4.27582712
5	Increased CSF lactate (HP:0002490)	4.13840407
6	Progressive macrocephaly (HP:0004481)	4.11546122
7	Methylmalonic aciduria (HP:0012120)	3.92483437
8	Increased hepatocellular lipid droplets (HP:0006565)	3.90462125
9	Lipid accumulation in hepatocytes (HP:0006561)	3.70129349
10	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.54148721
11	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.54148721
12	Hepatocellular necrosis (HP:0001404)	3.47286134
13	Methylmalonic acidemia (HP:0002912)	3.45872618
14	Renal Fanconi syndrome (HP:0001994)	3.45013311
15	Increased intramyocellular lipid droplets (HP:0012240)	3.40597813
16	Stenosis of the external auditory canal (HP:0000402)	3.37015387
17	Cerebral edema (HP:0002181)	3.34157831
18	Hepatic necrosis (HP:0002605)	3.28980277
19	Conjunctival hamartoma (HP:0100780)	3.26134054
20	Type I transferrin isoform profile (HP:0003642)	3.19957884
21	Short tibia (HP:0005736)	3.16856602
22	Increased muscle lipid content (HP:0009058)	2.91502634
23	Septo-optic dysplasia (HP:0100842)	2.89732014
24	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.85664187
25	IgM deficiency (HP:0002850)	2.70154071
26	Lethargy (HP:0001254)	2.68110274
27	Lactic acidosis (HP:0003128)	2.66880005
28	Hypoplastic pelvis (HP:0008839)	2.64787233
29	3-Methylglutaconic aciduria (HP:0003535)	2.62330860
30	Generalized aminoaciduria (HP:0002909)	2.59061776
31	Palpitations (HP:0001962)	2.55982471
32	Dicarboxylic aciduria (HP:0003215)	2.54318823
33	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.54318823
34	Hyperglycinemia (HP:0002154)	2.50980290
35	Abnormality of urine glucose concentration (HP:0011016)	2.49588635
36	Glycosuria (HP:0003076)	2.49588635
37	Respiratory difficulties (HP:0002880)	2.48287342
38	Abnormality of serum amino acid levels (HP:0003112)	2.48001392
39	Abnormality of alanine metabolism (HP:0010916)	2.46413796
40	Hyperalaninemia (HP:0003348)	2.46413796
41	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.46413796
42	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.44929002
43	Optic disc pallor (HP:0000543)	2.44873865
44	Increased serum lactate (HP:0002151)	2.44000688
45	Congenital, generalized hypertrichosis (HP:0004540)	2.43716239
46	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.40756702
47	Abnormal protein N-linked glycosylation (HP:0012347)	2.40756702
48	Abnormal protein glycosylation (HP:0012346)	2.40756702
49	Abnormal glycosylation (HP:0012345)	2.40756702
50	Nausea (HP:0002018)	2.37199368
51	Respiratory failure (HP:0002878)	2.33719855
52	Abnormality of midbrain morphology (HP:0002418)	2.32400539
53	Molar tooth sign on MRI (HP:0002419)	2.32400539
54	Leukodystrophy (HP:0002415)	2.28630848
55	Exercise intolerance (HP:0003546)	2.24921000
56	Abnormality of vitamin B metabolism (HP:0004340)	2.24613040
57	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.24093801
58	Exertional dyspnea (HP:0002875)	2.23574594
59	Carpal bone hypoplasia (HP:0001498)	2.19744048
60	Abnormality of renal resorption (HP:0011038)	2.18460833
61	Pancreatic cysts (HP:0001737)	2.18257057
62	Adrenal hypoplasia (HP:0000835)	2.13972385
63	B lymphocytopenia (HP:0010976)	2.12757524
64	Meningioma (HP:0002858)	2.10125269
65	Nephronophthisis (HP:0000090)	2.09850796
66	Abnormality of B cell number (HP:0010975)	2.08409798
67	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.03711190
68	Renal cortical cysts (HP:0000803)	2.02793041
69	True hermaphroditism (HP:0010459)	2.02651635
70	Abnormality of the fetal cardiovascular system (HP:0010948)	1.98803814
71	Abnormal umbilical cord blood vessels (HP:0011403)	1.98803814
72	Single umbilical artery (HP:0001195)	1.98803814
73	Hypoplasia of the uterus (HP:0000013)	1.98271023
74	Aplasia/hypoplasia of the uterus (HP:0008684)	1.97827156
75	CNS demyelination (HP:0007305)	1.97650593
76	T lymphocytopenia (HP:0005403)	1.96623055
77	X-linked dominant inheritance (HP:0001423)	1.96604664
78	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95829311
79	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.94444653
80	Eosinophilia (HP:0001880)	1.94026625
81	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.93032262
82	Oral leukoplakia (HP:0002745)	1.91978125
83	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.91113015
84	Absent septum pellucidum (HP:0001331)	1.90323141
85	Abnormality of T cell number (HP:0011839)	1.86330869
86	Pancreatic fibrosis (HP:0100732)	1.84950108
87	Microretrognathia (HP:0000308)	1.84149483
88	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.83806717
89	Hypokinesia (HP:0002375)	1.81701425
90	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.80884307
91	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.80739036
92	Hyperphosphaturia (HP:0003109)	1.80097102
93	Abnormality of T cells (HP:0002843)	1.78956264
94	Macrocytic anemia (HP:0001972)	1.78843793
95	Short 1st metacarpal (HP:0010034)	1.78393731
96	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.78393731
97	Aplastic anemia (HP:0001915)	1.77231145
98	Poor speech (HP:0002465)	1.76717577
99	Colon cancer (HP:0003003)	1.74645200
100	Tinnitus (HP:0000360)	1.74592839

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	3.64537137
2	MST4	3.60375015
3	EIF2AK3	3.47456509
4	NME2	3.28910515
5	STK16	3.19486002
6	PDK2	2.96193827
7	VRK2	2.90369746
8	NEK1	2.70108106
9	EIF2AK1	2.67555124
10	SRPK1	2.51608513
11	MAP3K12	2.51046686
12	PBK	2.07409340
13	BUB1	1.98717166
14	TESK1	1.86197331
15	TRIM28	1.85343441
16	LIMK1	1.74205706
17	CDK19	1.63096243
18	TESK2	1.61281533
19	CSNK1G3	1.51019199
20	KDR	1.49735254
21	NUAK1	1.48258099
22	GRK1	1.47662501
23	ZAK	1.47392237
24	WNK3	1.41047871
25	MAP4K2	1.36812524
26	CSNK1A1L	1.28108072
27	PAK4	1.27956364
28	INSRR	1.27462774
29	PLK4	1.21040203
30	NME1	1.16238802
31	TNIK	1.09431500
32	VRK1	1.09179952
33	TXK	1.07254605
34	MAP2K7	1.07245834
35	CSNK1G2	1.07146019
36	CSNK1G1	1.05085158
37	EIF2AK2	1.04084202
38	PLK3	0.98344394
39	PINK1	0.98280826
40	OXSR1	0.97757400
41	TTK	0.97644130
42	BMPR1B	0.94854103
43	WEE1	0.94188022
44	RPS6KA4	0.94033876
45	EPHA2	0.91896951
46	MYLK	0.89293524
47	BRSK2	0.87623824
48	DYRK2	0.83247728
49	PLK2	0.80684278
50	PLK1	0.80625608
51	BCR	0.80079756
52	MKNK2	0.77040105
53	MKNK1	0.74478464
54	EPHA3	0.72041248
55	FRK	0.69131246
56	DAPK1	0.66677907
57	MAP3K4	0.65737164
58	LMTK2	0.64239113
59	TLK1	0.62769259
60	PRKCE	0.61109974
61	AURKB	0.60576346
62	PIM2	0.57885805
63	RPS6KA5	0.57776290
64	FGFR1	0.57613946
65	RIPK4	0.55915869
66	MAPKAPK3	0.53892842
67	CSNK2A1	0.52503657
68	STK39	0.49744036
69	ARAF	0.47554452
70	FER	0.46423031
71	BRSK1	0.46137889
72	PASK	0.45903059
73	PTK6	0.45708916
74	CSNK1A1	0.45704329
75	CSNK2A2	0.45340373
76	TAF1	0.44334618
77	PRKCQ	0.42715832
78	CDK3	0.42504805
79	NEK2	0.42215643
80	AURKA	0.40576713
81	FES	0.39767528
82	PRKG2	0.39754230
83	MAPK13	0.39558504
84	CAMK2G	0.39074276
85	ADRBK2	0.37379816
86	CDK9	0.37051160
87	PRKCI	0.34263118
88	PRKD2	0.34217555
89	IGF1R	0.34026259
90	CASK	0.33473258
91	LCK	0.33137720
92	AKT2	0.32322895
93	CDC7	0.31433477
94	ACVR1B	0.30902867
95	PRKCA	0.29446574
96	ERBB4	0.29356893
97	EGFR	0.29194027
98	CHEK2	0.28965442
99	CLK1	0.28564523
100	CDK11A	0.28252176

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.21219400
2	Protein export_Homo sapiens_hsa03060	3.89288982
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.82663560
4	Parkinsons disease_Homo sapiens_hsa05012	3.33696652
5	Ribosome_Homo sapiens_hsa03010	3.11237424
6	RNA polymerase_Homo sapiens_hsa03020	2.81850075
7	Huntingtons disease_Homo sapiens_hsa05016	2.40141327
8	Alzheimers disease_Homo sapiens_hsa05010	2.16381826
9	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.07901610
10	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.98536005
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.97483833
12	Mismatch repair_Homo sapiens_hsa03430	1.91020008
13	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.82949395
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.73859460
15	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.64039668
16	Pyrimidine metabolism_Homo sapiens_hsa00240	1.61184163
17	DNA replication_Homo sapiens_hsa03030	1.59923750
18	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.58549653
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.56366535
20	Homologous recombination_Homo sapiens_hsa03440	1.50408400
21	Glutathione metabolism_Homo sapiens_hsa00480	1.49131423
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.47305841
23	Chemical carcinogenesis_Homo sapiens_hsa05204	1.47288308
24	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.46908075
25	Base excision repair_Homo sapiens_hsa03410	1.39065228
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.38578919
27	Spliceosome_Homo sapiens_hsa03040	1.38416532
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.34469470
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.27968520
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21252470
31	Sulfur metabolism_Homo sapiens_hsa00920	1.21159561
32	Retinol metabolism_Homo sapiens_hsa00830	1.21132802
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.16439923
34	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.15471215
35	Basal transcription factors_Homo sapiens_hsa03022	1.13566252
36	Propanoate metabolism_Homo sapiens_hsa00640	1.10557433
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06677340
38	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.05967362
39	Fat digestion and absorption_Homo sapiens_hsa04975	1.05689761
40	Purine metabolism_Homo sapiens_hsa00230	1.05582734
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.05380723
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.04260204
43	Primary immunodeficiency_Homo sapiens_hsa05340	1.03937616
44	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.03599400
45	Folate biosynthesis_Homo sapiens_hsa00790	1.03484739
46	Peroxisome_Homo sapiens_hsa04146	1.02049606
47	RNA transport_Homo sapiens_hsa03013	1.01291010
48	Caffeine metabolism_Homo sapiens_hsa00232	0.97122562
49	One carbon pool by folate_Homo sapiens_hsa00670	0.93647354
50	RNA degradation_Homo sapiens_hsa03018	0.91576552
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.88304768
52	Metabolic pathways_Homo sapiens_hsa01100	0.86644011
53	Fatty acid elongation_Homo sapiens_hsa00062	0.84427846
54	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.78834689
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.77483139
56	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.76791160
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72301648
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65150266
59	Fatty acid degradation_Homo sapiens_hsa00071	0.64048780
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.63301756
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.62817990
62	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.60927297
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.60526951
64	Sulfur relay system_Homo sapiens_hsa04122	0.60169174
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.60107271
66	p53 signaling pathway_Homo sapiens_hsa04115	0.59316212
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.56699980
68	Mineral absorption_Homo sapiens_hsa04978	0.55926107
69	Renin-angiotensin system_Homo sapiens_hsa04614	0.54049327
70	Pancreatic secretion_Homo sapiens_hsa04972	0.53721472
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52651932
72	Phototransduction_Homo sapiens_hsa04744	0.51266981
73	Vibrio cholerae infection_Homo sapiens_hsa05110	0.50882544
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.50287457
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49411538
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49265689
77	Rheumatoid arthritis_Homo sapiens_hsa05323	0.49005988
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47256961
79	Carbon metabolism_Homo sapiens_hsa01200	0.46946044
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45753277
81	Antigen processing and presentation_Homo sapiens_hsa04612	0.44855597
82	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.44746144
83	Cell cycle_Homo sapiens_hsa04110	0.44715911
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.41898374
85	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.41876648
86	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40609982
87	Protein digestion and absorption_Homo sapiens_hsa04974	0.39383982
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39154323
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.39102178
90	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.38727508
91	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.38533605
92	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36419726
93	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.36321841
94	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.35788819
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.35114952
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.33716861
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.32866117
98	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.30696838
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.30526439
100	Oocyte meiosis_Homo sapiens_hsa04114	0.30413484

KRT18P58

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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