ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	somatic hypermutation of immunoglobulin genes (GO:0016446)	6.57771536
2	somatic diversification of immune receptors via somatic mutation (GO:0002566)	6.57771536
3	gamma-aminobutyric acid transport (GO:0015812)	6.41973679
4	regulation of protein polyubiquitination (GO:1902914)	5.48481300
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.16419927
6	regulation of helicase activity (GO:0051095)	5.16099305
7	behavioral response to nicotine (GO:0035095)	5.12984499
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.58173768
9	ATP synthesis coupled proton transport (GO:0015986)	4.58173768
10	determination of adult lifespan (GO:0008340)	4.20355404
11	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.16616756
12	neuron fate determination (GO:0048664)	4.14169183
13	sequestering of actin monomers (GO:0042989)	3.98065192
14	reciprocal DNA recombination (GO:0035825)	3.73427376
15	reciprocal meiotic recombination (GO:0007131)	3.73427376
16	microtubule depolymerization (GO:0007019)	3.69192540
17	amino acid salvage (GO:0043102)	3.64568641
18	L-methionine salvage (GO:0071267)	3.64568641
19	L-methionine biosynthetic process (GO:0071265)	3.64568641
20	protein K6-linked ubiquitination (GO:0085020)	3.56802155
21	epithelial cilium movement (GO:0003351)	3.55845516
22	transmission of nerve impulse (GO:0019226)	3.47682520
23	protein-cofactor linkage (GO:0018065)	3.42712936
24	indolalkylamine metabolic process (GO:0006586)	3.40231302
25	nephron epithelium morphogenesis (GO:0072088)	3.39335705
26	nephron tubule morphogenesis (GO:0072078)	3.39335705
27	negative regulation of DNA recombination (GO:0045910)	3.38551936
28	protein neddylation (GO:0045116)	3.35793631
29	platelet dense granule organization (GO:0060155)	3.21327710
30	kynurenine metabolic process (GO:0070189)	3.20310982
31	indole-containing compound catabolic process (GO:0042436)	3.18070682
32	indolalkylamine catabolic process (GO:0046218)	3.18070682
33	tryptophan catabolic process (GO:0006569)	3.18070682
34	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.16544602
35	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.16544602
36	isotype switching (GO:0045190)	3.16544602
37	respiratory electron transport chain (GO:0022904)	3.14544928
38	electron transport chain (GO:0022900)	3.12847622
39	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.04013235
40	negative regulation of cell aging (GO:0090344)	3.03074808
41	cilium movement (GO:0003341)	3.02291684
42	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.01656169
43	alkaloid metabolic process (GO:0009820)	2.98865353
44	cornea development in camera-type eye (GO:0061303)	2.94113365
45	neuronal action potential (GO:0019228)	2.93454770
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.93205177
47	NADH dehydrogenase complex assembly (GO:0010257)	2.93205177
48	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.93205177
49	proline transport (GO:0015824)	2.87978622
50	pyrimidine nucleobase catabolic process (GO:0006208)	2.86955338
51	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.84979140
52	protein complex biogenesis (GO:0070271)	2.84045612
53	postsynaptic membrane organization (GO:0001941)	2.83928818
54	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.83400616
55	viral transcription (GO:0019083)	2.80846551
56	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.79621020
57	presynaptic membrane assembly (GO:0097105)	2.79566618
58	somite development (GO:0061053)	2.78440167
59	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.76561195
60	translational termination (GO:0006415)	2.75714461
61	positive regulation of fatty acid oxidation (GO:0046321)	2.72591617
62	GTP biosynthetic process (GO:0006183)	2.71536940
63	DNA deamination (GO:0045006)	2.69307276
64	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.68745576
65	ATP biosynthetic process (GO:0006754)	2.67864092
66	proteasome assembly (GO:0043248)	2.66902033
67	methionine biosynthetic process (GO:0009086)	2.66481955
68	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.64741815
69	indole-containing compound metabolic process (GO:0042430)	2.64137041
70	startle response (GO:0001964)	2.62625185
71	sulfation (GO:0051923)	2.61942703
72	piRNA metabolic process (GO:0034587)	2.61272703
73	protein localization to synapse (GO:0035418)	2.59261959
74	renal tubule morphogenesis (GO:0061333)	2.58734020
75	mitochondrial respiratory chain complex assembly (GO:0033108)	2.58658454
76	synapsis (GO:0007129)	2.58125917
77	retinal cone cell development (GO:0046549)	2.56342980
78	tryptophan metabolic process (GO:0006568)	2.54939999
79	regulation of timing of cell differentiation (GO:0048505)	2.54244720
80	rRNA modification (GO:0000154)	2.53697129
81	negative regulation of telomere maintenance (GO:0032205)	2.53571424
82	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.53070885
83	hydrogen ion transmembrane transport (GO:1902600)	2.52744979
84	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.52340067
85	nephron tubule formation (GO:0072079)	2.51725674
86	neuronal stem cell maintenance (GO:0097150)	2.51671383
87	water-soluble vitamin biosynthetic process (GO:0042364)	2.51655943
88	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.51275503
89	behavioral response to ethanol (GO:0048149)	2.50123320
90	copper ion homeostasis (GO:0055070)	2.49431539
91	cAMP catabolic process (GO:0006198)	2.47847742
92	toxin metabolic process (GO:0009404)	2.47114322
93	cotranslational protein targeting to membrane (GO:0006613)	2.46534136
94	respiratory chain complex IV assembly (GO:0008535)	2.46086072
95	nucleobase catabolic process (GO:0046113)	2.44995321
96	preassembly of GPI anchor in ER membrane (GO:0016254)	2.44719538
97	axoneme assembly (GO:0035082)	2.43749374
98	response to pheromone (GO:0019236)	2.42540672
99	rhodopsin mediated signaling pathway (GO:0016056)	2.41536286
100	adult feeding behavior (GO:0008343)	2.41459718

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.41581962
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.35564179
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.23734693
4	VDR_22108803_ChIP-Seq_LS180_Human	2.74874304
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.59069510
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.47616232
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.47390275
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.33532941
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.25661100
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.21398484
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.18548987
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15687484
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13167347
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04368113
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.03878684
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.03285465
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.01719345
18	EWS_26573619_Chip-Seq_HEK293_Human	1.99921961
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89450445
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.89106056
21	P300_19829295_ChIP-Seq_ESCs_Human	1.89048813
22	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.88191970
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.87877726
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.86716877
25	FUS_26573619_Chip-Seq_HEK293_Human	1.86085688
26	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.82908339
27	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.74275406
28	RNF2_27304074_Chip-Seq_NSC_Mouse	1.73825246
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68849496
30	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.65912991
31	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.64919479
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60865077
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59721381
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.56225330
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56013997
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49390585
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46471103
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.43620573
39	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.42783889
40	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.41022027
41	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.40739616
42	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.40663941
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40451690
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40451690
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39891910
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.38686547
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38472604
48	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.37418664
49	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.37030387
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36417749
51	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.36089840
52	AR_25329375_ChIP-Seq_VCAP_Human	1.35415098
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32906132
54	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.32741822
55	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.32734240
56	IGF1R_20145208_ChIP-Seq_DFB_Human	1.32087061
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30874496
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30874496
59	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.30487096
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.30197720
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30197720
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.30144861
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27802887
64	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.27553294
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25655761
66	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25297576
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24686661
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.23831185
69	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23509934
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23006161
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17754870
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17754870
73	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.16921413
74	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.15506936
75	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.10388145
76	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.09490242
77	STAT3_23295773_ChIP-Seq_U87_Human	1.09489201
78	SMAD4_21799915_ChIP-Seq_A2780_Human	1.08349920
79	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.08105988
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07597285
81	NCOR_22424771_ChIP-Seq_293T_Human	1.07385398
82	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07229494
83	HTT_18923047_ChIP-ChIP_STHdh_Human	1.06456108
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06322556
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06190903
86	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05048154
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04674130
88	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.04472053
89	BCAT_22108803_ChIP-Seq_LS180_Human	1.04128016
90	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.03172803
91	TCF4_22108803_ChIP-Seq_LS180_Human	1.02271694
92	AR_20517297_ChIP-Seq_VCAP_Human	1.01495029
93	ELK1_19687146_ChIP-ChIP_HELA_Human	1.01153770
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00607171
95	TP53_22573176_ChIP-Seq_HFKS_Human	0.99998171
96	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99954176
97	E2F7_22180533_ChIP-Seq_HELA_Human	0.99937300
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98084224
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97102974
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96840087

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.85704158
2	MP0003136_yellow_coat_color	3.49572282
3	MP0003011_delayed_dark_adaptation	3.01514614
4	MP0005551_abnormal_eye_electrophysiolog	2.55137909
5	MP0004142_abnormal_muscle_tone	2.51135648
6	MP0008875_abnormal_xenobiotic_pharmacok	2.45502765
7	MP0005645_abnormal_hypothalamus_physiol	2.41420299
8	MP0001485_abnormal_pinna_reflex	2.22845093
9	MP0002736_abnormal_nociception_after	2.07224549
10	MP0009745_abnormal_behavioral_response	2.02609218
11	MP0001968_abnormal_touch/_nociception	2.02488014
12	MP0003195_calcinosis	1.98844605
13	MP0002163_abnormal_gland_morphology	1.95258024
14	MP0002938_white_spotting	1.93534543
15	MP0005646_abnormal_pituitary_gland	1.93113877
16	MP0006072_abnormal_retinal_apoptosis	1.89571943
17	MP0000631_abnormal_neuroendocrine_gland	1.85416818
18	MP0003880_abnormal_central_pattern	1.76407850
19	MP0006292_abnormal_olfactory_placode	1.75145839
20	MP0005379_endocrine/exocrine_gland_phen	1.73856463
21	MP0002653_abnormal_ependyma_morphology	1.73637021
22	MP0004742_abnormal_vestibular_system	1.72499306
23	MP0005253_abnormal_eye_physiology	1.71842852
24	MP0009046_muscle_twitch	1.71401922
25	MP0009379_abnormal_foot_pigmentation	1.67893592
26	MP0000569_abnormal_digit_pigmentation	1.66409602
27	MP0002638_abnormal_pupillary_reflex	1.65832666
28	MP0005423_abnormal_somatic_nervous	1.63939144
29	MP0003122_maternal_imprinting	1.54579798
30	MP0002272_abnormal_nervous_system	1.53405595
31	MP0002064_seizures	1.48914821
32	MP0000372_irregular_coat_pigmentation	1.46732373
33	MP0010386_abnormal_urinary_bladder	1.43074103
34	MP0004885_abnormal_endolymph	1.42060459
35	MP0003635_abnormal_synaptic_transmissio	1.41692677
36	MP0004147_increased_porphyrin_level	1.40510363
37	MP0001984_abnormal_olfaction	1.40303978
38	MP0008872_abnormal_physiological_respon	1.39039974
39	MP0002572_abnormal_emotion/affect_behav	1.38796542
40	MP0002557_abnormal_social/conspecific_i	1.34464089
41	MP0002277_abnormal_respiratory_mucosa	1.34328596
42	MP0003787_abnormal_imprinting	1.32487651
43	MP0002837_dystrophic_cardiac_calcinosis	1.32112590
44	MP0002067_abnormal_sensory_capabilities	1.31449608
45	MP0000566_synostosis	1.30909444
46	MP0001501_abnormal_sleep_pattern	1.29893304
47	MP0001986_abnormal_taste_sensitivity	1.29490516
48	MP0002876_abnormal_thyroid_physiology	1.29203364
49	MP0000026_abnormal_inner_ear	1.25922224
50	MP0000049_abnormal_middle_ear	1.25108457
51	MP0003567_abnormal_fetal_cardiomyocyte	1.24587198
52	MP0001486_abnormal_startle_reflex	1.22226149
53	MP0005195_abnormal_posterior_eye	1.15863520
54	MP0001881_abnormal_mammary_gland	1.14740460
55	MP0001905_abnormal_dopamine_level	1.14252863
56	MP0004133_heterotaxia	1.12829705
57	MP0005167_abnormal_blood-brain_barrier	1.10293610
58	MP0001970_abnormal_pain_threshold	1.07321680
59	MP0003121_genomic_imprinting	1.07134827
60	MP0002751_abnormal_autonomic_nervous	1.06388847
61	MP0002095_abnormal_skin_pigmentation	1.06381583
62	MP0002160_abnormal_reproductive_system	1.05339733
63	MP0002063_abnormal_learning/memory/cond	1.04678870
64	MP0004924_abnormal_behavior	1.03640982
65	MP0005386_behavior/neurological_phenoty	1.03640982
66	MP0002735_abnormal_chemical_nociception	1.03284372
67	MP0002752_abnormal_somatic_nervous	1.02085643
68	MP0005084_abnormal_gallbladder_morpholo	1.01747830
69	MP0006276_abnormal_autonomic_nervous	1.00822568
70	MP0009384_cardiac_valve_regurgitation	0.99937277
71	MP0003137_abnormal_impulse_conducting	0.99501684
72	MP0005389_reproductive_system_phenotype	0.98008943
73	MP0000955_abnormal_spinal_cord	0.97997516
74	MP0003283_abnormal_digestive_organ	0.97595889
75	MP0002734_abnormal_mechanical_nocicepti	0.97530851
76	MP0000427_abnormal_hair_cycle	0.96858800
77	MP0010030_abnormal_orbit_morphology	0.96397282
78	MP0005085_abnormal_gallbladder_physiolo	0.96066111
79	MP0002102_abnormal_ear_morphology	0.95613834
80	MP0004043_abnormal_pH_regulation	0.94024395
81	MP0002733_abnormal_thermal_nociception	0.93498352
82	MP0001529_abnormal_vocalization	0.92746687
83	MP0002234_abnormal_pharynx_morphology	0.92643981
84	MP0004215_abnormal_myocardial_fiber	0.90398961
85	MP0005410_abnormal_fertilization	0.90099079
86	MP0003938_abnormal_ear_development	0.87950217
87	MP0001440_abnormal_grooming_behavior	0.86904168
88	MP0001963_abnormal_hearing_physiology	0.85751716
89	MP0003119_abnormal_digestive_system	0.83536994
90	MP0005391_vision/eye_phenotype	0.83015875
91	MP0000778_abnormal_nervous_system	0.82310040
92	MP0005174_abnormal_tail_pigmentation	0.81677552
93	MP0003698_abnormal_male_reproductive	0.81569071
94	MP0005075_abnormal_melanosome_morpholog	0.80337984
95	MP0003936_abnormal_reproductive_system	0.80038084
96	MP0001293_anophthalmia	0.78921148
97	MP0001324_abnormal_eye_pigmentation	0.76628886
98	MP0002909_abnormal_adrenal_gland	0.76550128
99	MP0002184_abnormal_innervation	0.76464284
100	MP0001919_abnormal_reproductive_system	0.76437853

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ependymoma (HP:0002888)	4.59884595
2	Agnosia (HP:0010524)	4.44507062
3	Type II lissencephaly (HP:0007260)	3.94026076
4	Congenital stationary night blindness (HP:0007642)	3.68240743
5	Pancreatic cysts (HP:0001737)	3.65568481
6	Abnormality of the pons (HP:0007361)	3.58875023
7	Hypoplasia of the pons (HP:0012110)	3.46624234
8	Cerebellar dysplasia (HP:0007033)	3.45923792
9	Medulloblastoma (HP:0002885)	3.42797089
10	Abnormality of the astrocytes (HP:0100707)	3.40607925
11	Astrocytoma (HP:0009592)	3.40607925
12	True hermaphroditism (HP:0010459)	3.38744253
13	Abnormality of alanine metabolism (HP:0010916)	3.27132514
14	Hyperalaninemia (HP:0003348)	3.27132514
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.27132514
16	Glioma (HP:0009733)	3.20687462
17	Rhabdomyosarcoma (HP:0002859)	3.14882737
18	Molar tooth sign on MRI (HP:0002419)	3.09131140
19	Abnormality of midbrain morphology (HP:0002418)	3.09131140
20	Pancreatic fibrosis (HP:0100732)	3.02091886
21	Neoplasm of the oral cavity (HP:0100649)	2.89089867
22	Neuroendocrine neoplasm (HP:0100634)	2.88110309
23	Lipid accumulation in hepatocytes (HP:0006561)	2.79052671
24	Atonic seizures (HP:0010819)	2.75144753
25	Hypothermia (HP:0002045)	2.74439752
26	Limb dystonia (HP:0002451)	2.70437548
27	Biliary tract neoplasm (HP:0100574)	2.68362099
28	Large for gestational age (HP:0001520)	2.68073232
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.63291842
30	Nephronophthisis (HP:0000090)	2.62363894
31	Abnormal number of erythroid precursors (HP:0012131)	2.61097994
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.57891117
33	Absent/shortened dynein arms (HP:0200106)	2.57891117
34	Congenital, generalized hypertrichosis (HP:0004540)	2.55785281
35	Increased hepatocellular lipid droplets (HP:0006565)	2.52468042
36	Hyperventilation (HP:0002883)	2.40139177
37	Abnormality of the renal medulla (HP:0100957)	2.37002751
38	Sclerocornea (HP:0000647)	2.35420635
39	Neoplasm of striated muscle (HP:0009728)	2.33664610
40	Abnormality of cells of the erythroid lineage (HP:0012130)	2.31696258
41	Attenuation of retinal blood vessels (HP:0007843)	2.27743231
42	Abnormality of the renal cortex (HP:0011035)	2.27546154
43	Adenoma sebaceum (HP:0009720)	2.26552753
44	Angiofibromas (HP:0010615)	2.26552753
45	Abnormal ciliary motility (HP:0012262)	2.20918866
46	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.20822793
47	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20100314
48	Reticulocytopenia (HP:0001896)	2.19396040
49	Neoplasm of the rectum (HP:0100743)	2.19386130
50	Lissencephaly (HP:0001339)	2.18947570
51	Mitochondrial inheritance (HP:0001427)	2.12843230
52	Febrile seizures (HP:0002373)	2.11413156
53	Duplicated collecting system (HP:0000081)	2.11304896
54	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.09555141
55	Retinal dysplasia (HP:0007973)	2.09472590
56	Decreased central vision (HP:0007663)	2.08732179
57	Constricted visual fields (HP:0001133)	2.07110242
58	Increased CSF lactate (HP:0002490)	2.06498020
59	Abnormality of the labia minora (HP:0012880)	2.06355122
60	Abnormality of the renal collecting system (HP:0004742)	2.05195744
61	Abnormal respiratory motile cilium morphology (HP:0005938)	2.00298854
62	Abnormal respiratory epithelium morphology (HP:0012253)	2.00298854
63	Hepatic necrosis (HP:0002605)	2.00018195
64	Absent septum pellucidum (HP:0001331)	1.99240882
65	Increased serum ferritin (HP:0003281)	1.99147892
66	Abnormality of the ileum (HP:0001549)	1.96544489
67	Pheochromocytoma (HP:0002666)	1.96229125
68	Abnormality of transition element cation homeostasis (HP:0011030)	1.95000441
69	Acute necrotizing encephalopathy (HP:0006965)	1.94946927
70	Focal motor seizures (HP:0011153)	1.94485864
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.93855072
72	Meckel diverticulum (HP:0002245)	1.92867624
73	Pendular nystagmus (HP:0012043)	1.92840435
74	Abnormal biliary tract morphology (HP:0012440)	1.90778874
75	Medial flaring of the eyebrow (HP:0010747)	1.89502445
76	Absence seizures (HP:0002121)	1.89360651
77	Abnormal pupillary function (HP:0007686)	1.87680344
78	Dialeptic seizures (HP:0011146)	1.87066039
79	Renal cortical cysts (HP:0000803)	1.86261065
80	3-Methylglutaconic aciduria (HP:0003535)	1.84884099
81	Acute encephalopathy (HP:0006846)	1.84404752
82	Abnormality of the salivary glands (HP:0010286)	1.83790018
83	Abnormality of iron homeostasis (HP:0011031)	1.83423883
84	Neoplasm of the liver (HP:0002896)	1.82691818
85	Pachygyria (HP:0001302)	1.81786867
86	Supernumerary spleens (HP:0009799)	1.80526332
87	Glycosuria (HP:0003076)	1.79004656
88	Abnormality of urine glucose concentration (HP:0011016)	1.79004656
89	Renal Fanconi syndrome (HP:0001994)	1.78571452
90	Basal cell carcinoma (HP:0002671)	1.78116495
91	Cerebral hypomyelination (HP:0006808)	1.77888650
92	Abnormal respiratory motile cilium physiology (HP:0012261)	1.77865830
93	Cystic liver disease (HP:0006706)	1.77631189
94	Anencephaly (HP:0002323)	1.77278175
95	Gait imbalance (HP:0002141)	1.76547624
96	Hepatocellular necrosis (HP:0001404)	1.75546758
97	Keratoconus (HP:0000563)	1.74788613
98	Increased corneal curvature (HP:0100692)	1.74788613
99	Benign neoplasm of the central nervous system (HP:0100835)	1.74304213
100	Tubular atrophy (HP:0000092)	1.73369581

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.67948692
2	DAPK2	3.01666949
3	WNK3	2.99873390
4	PAK4	2.94545689
5	FRK	2.82618085
6	TLK1	2.78432238
7	ZAK	2.33009941
8	WNK4	2.25651862
9	GRK1	2.21632128
10	MAPK13	2.15384475
11	ADRBK2	2.08206174
12	CASK	1.97988802
13	TNIK	1.94902609
14	PINK1	1.89904639
15	BMPR1B	1.76980813
16	ACVR1B	1.71055198
17	PAK3	1.65772838
18	NME1	1.60038408
19	MARK1	1.58100473
20	TSSK6	1.53390972
21	NUAK1	1.50368253
22	OXSR1	1.46005244
23	INSRR	1.32448609
24	KIT	1.31924695
25	DYRK2	1.29889175
26	MKNK2	1.29595787
27	MUSK	1.28943070
28	VRK1	1.28079899
29	LIMK1	1.26807877
30	PDK2	1.21346914
31	CCNB1	1.18463475
32	TXK	1.16907887
33	STK38L	1.16554248
34	EIF2AK3	1.16313341
35	MAP3K4	1.15138592
36	TRIM28	1.14166333
37	WEE1	1.13805410
38	MAPK15	1.13553377
39	TAOK3	1.12552160
40	STK16	1.12214430
41	MKNK1	1.09569905
42	TGFBR1	1.08426097
43	PNCK	1.08354907
44	STK39	1.06228832
45	ADRBK1	1.05615515
46	BCKDK	1.03133825
47	UHMK1	1.02566125
48	PASK	0.97423981
49	SRPK1	0.95694768
50	PRKCG	0.94966675
51	PRKCE	0.93467058
52	PLK3	0.93108556
53	PHKG2	0.87583161
54	PHKG1	0.87583161
55	TAF1	0.84803784
56	MAPKAPK5	0.80997197
57	MAP3K12	0.77251870
58	PIK3CA	0.74483882
59	AKT2	0.73501921
60	CSNK1D	0.70666067
61	CAMKK2	0.69810857
62	PLK4	0.69421556
63	CAMK2A	0.69418910
64	PTK2B	0.68404686
65	NTRK3	0.63190644
66	EIF2AK1	0.61357993
67	TIE1	0.59909220
68	DYRK1B	0.59877035
69	MAP2K7	0.57500700
70	BRSK2	0.57069971
71	CSNK1A1	0.53025140
72	PKN1	0.52464223
73	PRKG1	0.52298868
74	CSNK1G2	0.51999696
75	CSNK1G1	0.50376897
76	STK11	0.49464235
77	CSNK1G3	0.49332193
78	PRKACA	0.48129428
79	MAPKAPK3	0.47416907
80	PLK2	0.47374109
81	BCR	0.47162723
82	FGFR2	0.47122153
83	ROCK1	0.45648759
84	TEC	0.44197585
85	CAMK1D	0.43699779
86	CAMK1	0.43408667
87	RPS6KA6	0.42261597
88	EPHA4	0.41690140
89	CDK3	0.41613419
90	CHEK2	0.41009569
91	RPS6KA5	0.38755151
92	VRK2	0.37659313
93	OBSCN	0.36796256
94	PRKCA	0.36381220
95	IKBKB	0.35618742
96	EIF2AK2	0.35032165
97	ERBB4	0.34858402
98	PRKCI	0.32022788
99	CAMK2B	0.32000997
100	PRKAA1	0.31839930

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.43784558
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.10474168
3	Phototransduction_Homo sapiens_hsa04744	3.00017276
4	Parkinsons disease_Homo sapiens_hsa05012	2.96928588
5	Ribosome_Homo sapiens_hsa03010	2.93827877
6	Nicotine addiction_Homo sapiens_hsa05033	2.53061229
7	Mismatch repair_Homo sapiens_hsa03430	2.37466430
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.31324500
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.26046732
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.21885290
11	Caffeine metabolism_Homo sapiens_hsa00232	2.14957556
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.14212892
13	Huntingtons disease_Homo sapiens_hsa05016	2.05306543
14	Tryptophan metabolism_Homo sapiens_hsa00380	2.02073079
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.98311538
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.93932578
17	Homologous recombination_Homo sapiens_hsa03440	1.93426752
18	Alzheimers disease_Homo sapiens_hsa05010	1.90005053
19	RNA polymerase_Homo sapiens_hsa03020	1.84273227
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.77584175
21	Protein export_Homo sapiens_hsa03060	1.72475221
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.70902244
23	Taste transduction_Homo sapiens_hsa04742	1.61485326
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.60809046
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.58701971
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.55491412
27	Butanoate metabolism_Homo sapiens_hsa00650	1.54730327
28	Propanoate metabolism_Homo sapiens_hsa00640	1.54277204
29	Morphine addiction_Homo sapiens_hsa05032	1.41661856
30	Histidine metabolism_Homo sapiens_hsa00340	1.40785502
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.32563708
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.27561238
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.27175284
34	Proteasome_Homo sapiens_hsa03050	1.24748234
35	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.22830520
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.22607611
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18964912
38	Olfactory transduction_Homo sapiens_hsa04740	1.16479080
39	GABAergic synapse_Homo sapiens_hsa04727	1.15520641
40	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13847871
41	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98279365
42	Basal cell carcinoma_Homo sapiens_hsa05217	0.96269664
43	Basal transcription factors_Homo sapiens_hsa03022	0.95294707
44	Purine metabolism_Homo sapiens_hsa00230	0.93406561
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93093955
46	Circadian entrainment_Homo sapiens_hsa04713	0.86052993
47	Steroid biosynthesis_Homo sapiens_hsa00100	0.84499063
48	Serotonergic synapse_Homo sapiens_hsa04726	0.83535302
49	Sulfur relay system_Homo sapiens_hsa04122	0.82469683
50	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.80886805
51	Retinol metabolism_Homo sapiens_hsa00830	0.80165400
52	Fatty acid degradation_Homo sapiens_hsa00071	0.78722461
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.78666535
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.78661702
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76243596
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76014010
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.74160438
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73746647
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.73357708
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.72529916
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70026971
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66727185
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65897487
64	RNA degradation_Homo sapiens_hsa03018	0.60593723
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.59715190
66	Metabolic pathways_Homo sapiens_hsa01100	0.59031418
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.58160979
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.56536465
69	Cocaine addiction_Homo sapiens_hsa05030	0.55940545
70	Insulin secretion_Homo sapiens_hsa04911	0.54507765
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.53292839
72	Peroxisome_Homo sapiens_hsa04146	0.52964088
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.52863588
74	One carbon pool by folate_Homo sapiens_hsa00670	0.49790039
75	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47500013
76	Non-homologous end-joining_Homo sapiens_hsa03450	0.47117683
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44775025
78	Amphetamine addiction_Homo sapiens_hsa05031	0.44296570
79	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.42661743
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40896378
81	Phenylalanine metabolism_Homo sapiens_hsa00360	0.40817932
82	Salivary secretion_Homo sapiens_hsa04970	0.39235143
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38538595
84	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.38102767
85	RNA transport_Homo sapiens_hsa03013	0.38098984
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37717843
87	Tyrosine metabolism_Homo sapiens_hsa00350	0.37646148
88	Long-term depression_Homo sapiens_hsa04730	0.36019250
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34065080
90	Axon guidance_Homo sapiens_hsa04360	0.33823079
91	Mineral absorption_Homo sapiens_hsa04978	0.32674654
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31800550
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.30838467
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29715981
95	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.29476145
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.27897689
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.27387673
98	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.26615955
99	p53 signaling pathway_Homo sapiens_hsa04115	0.26025135
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.24980027

KRT18P59

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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