KRT18P59

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1somatic hypermutation of immunoglobulin genes (GO:0016446)6.57771536
2somatic diversification of immune receptors via somatic mutation (GO:0002566)6.57771536
3gamma-aminobutyric acid transport (GO:0015812)6.41973679
4regulation of protein polyubiquitination (GO:1902914)5.48481300
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.16419927
6regulation of helicase activity (GO:0051095)5.16099305
7behavioral response to nicotine (GO:0035095)5.12984499
8ATP synthesis coupled proton transport (GO:0015986)4.58173768
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.58173768
10determination of adult lifespan (GO:0008340)4.20355404
11L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.16616756
12neuron fate determination (GO:0048664)4.14169183
13sequestering of actin monomers (GO:0042989)3.98065192
14reciprocal DNA recombination (GO:0035825)3.73427376
15reciprocal meiotic recombination (GO:0007131)3.73427376
16microtubule depolymerization (GO:0007019)3.69192540
17amino acid salvage (GO:0043102)3.64568641
18L-methionine salvage (GO:0071267)3.64568641
19L-methionine biosynthetic process (GO:0071265)3.64568641
20protein K6-linked ubiquitination (GO:0085020)3.56802155
21epithelial cilium movement (GO:0003351)3.55845516
22transmission of nerve impulse (GO:0019226)3.47682520
23protein-cofactor linkage (GO:0018065)3.42712936
24indolalkylamine metabolic process (GO:0006586)3.40231302
25nephron tubule morphogenesis (GO:0072078)3.39335705
26nephron epithelium morphogenesis (GO:0072088)3.39335705
27negative regulation of DNA recombination (GO:0045910)3.38551936
28protein neddylation (GO:0045116)3.35793631
29platelet dense granule organization (GO:0060155)3.21327710
30kynurenine metabolic process (GO:0070189)3.20310982
31indole-containing compound catabolic process (GO:0042436)3.18070682
32indolalkylamine catabolic process (GO:0046218)3.18070682
33tryptophan catabolic process (GO:0006569)3.18070682
34somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.16544602
35isotype switching (GO:0045190)3.16544602
36somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.16544602
37respiratory electron transport chain (GO:0022904)3.14544928
38electron transport chain (GO:0022900)3.12847622
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.04013235
40negative regulation of cell aging (GO:0090344)3.03074808
41cilium movement (GO:0003341)3.02291684
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01656169
43alkaloid metabolic process (GO:0009820)2.98865353
44cornea development in camera-type eye (GO:0061303)2.94113365
45neuronal action potential (GO:0019228)2.93454770
46mitochondrial respiratory chain complex I assembly (GO:0032981)2.93205177
47NADH dehydrogenase complex assembly (GO:0010257)2.93205177
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93205177
49proline transport (GO:0015824)2.87978622
50pyrimidine nucleobase catabolic process (GO:0006208)2.86955338
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84979140
52protein complex biogenesis (GO:0070271)2.84045612
53postsynaptic membrane organization (GO:0001941)2.83928818
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.83400616
55viral transcription (GO:0019083)2.80846551
56establishment of protein localization to mitochondrial membrane (GO:0090151)2.79621020
57presynaptic membrane assembly (GO:0097105)2.79566618
58somite development (GO:0061053)2.78440167
59positive regulation of fatty acid beta-oxidation (GO:0032000)2.76561195
60translational termination (GO:0006415)2.75714461
61positive regulation of fatty acid oxidation (GO:0046321)2.72591617
62GTP biosynthetic process (GO:0006183)2.71536940
63DNA deamination (GO:0045006)2.69307276
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.68745576
65ATP biosynthetic process (GO:0006754)2.67864092
66proteasome assembly (GO:0043248)2.66902033
67methionine biosynthetic process (GO:0009086)2.66481955
68purine nucleoside triphosphate biosynthetic process (GO:0009145)2.64741815
69indole-containing compound metabolic process (GO:0042430)2.64137041
70startle response (GO:0001964)2.62625185
71sulfation (GO:0051923)2.61942703
72piRNA metabolic process (GO:0034587)2.61272703
73protein localization to synapse (GO:0035418)2.59261959
74renal tubule morphogenesis (GO:0061333)2.58734020
75mitochondrial respiratory chain complex assembly (GO:0033108)2.58658454
76synapsis (GO:0007129)2.58125917
77retinal cone cell development (GO:0046549)2.56342980
78tryptophan metabolic process (GO:0006568)2.54939999
79regulation of timing of cell differentiation (GO:0048505)2.54244720
80rRNA modification (GO:0000154)2.53697129
81negative regulation of telomere maintenance (GO:0032205)2.53571424
82regulation of rhodopsin mediated signaling pathway (GO:0022400)2.53070885
83hydrogen ion transmembrane transport (GO:1902600)2.52744979
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52340067
85nephron tubule formation (GO:0072079)2.51725674
86neuronal stem cell maintenance (GO:0097150)2.51671383
87water-soluble vitamin biosynthetic process (GO:0042364)2.51655943
88negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51275503
89behavioral response to ethanol (GO:0048149)2.50123320
90copper ion homeostasis (GO:0055070)2.49431539
91cAMP catabolic process (GO:0006198)2.47847742
92toxin metabolic process (GO:0009404)2.47114322
93cotranslational protein targeting to membrane (GO:0006613)2.46534136
94respiratory chain complex IV assembly (GO:0008535)2.46086072
95nucleobase catabolic process (GO:0046113)2.44995321
96preassembly of GPI anchor in ER membrane (GO:0016254)2.44719538
97axoneme assembly (GO:0035082)2.43749374
98response to pheromone (GO:0019236)2.42540672
99rhodopsin mediated signaling pathway (GO:0016056)2.41536286
100adult feeding behavior (GO:0008343)2.41459718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.41581962
2ZNF274_21170338_ChIP-Seq_K562_Hela3.35564179
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23734693
4VDR_22108803_ChIP-Seq_LS180_Human2.74874304
5GBX2_23144817_ChIP-Seq_PC3_Human2.59069510
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47616232
7TAF15_26573619_Chip-Seq_HEK293_Human2.47390275
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33532941
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25661100
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21398484
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.18548987
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15687484
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13167347
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.04368113
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03878684
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03285465
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01719345
18EWS_26573619_Chip-Seq_HEK293_Human1.99921961
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89450445
20ER_23166858_ChIP-Seq_MCF-7_Human1.89106056
21P300_19829295_ChIP-Seq_ESCs_Human1.89048813
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88191970
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87877726
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.86716877
25FUS_26573619_Chip-Seq_HEK293_Human1.86085688
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.82908339
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74275406
28RNF2_27304074_Chip-Seq_NSC_Mouse1.73825246
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68849496
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.65912991
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.64919479
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60865077
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59721381
34MYC_18940864_ChIP-ChIP_HL60_Human1.56225330
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.56013997
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49390585
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46471103
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43620573
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42783889
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41022027
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40739616
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40663941
43SOX2_19829295_ChIP-Seq_ESCs_Human1.40451690
44NANOG_19829295_ChIP-Seq_ESCs_Human1.40451690
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39891910
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.38686547
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38472604
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.37418664
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.37030387
50REST_21632747_ChIP-Seq_MESCs_Mouse1.36417749
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36089840
52AR_25329375_ChIP-Seq_VCAP_Human1.35415098
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32906132
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32741822
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32734240
56IGF1R_20145208_ChIP-Seq_DFB_Human1.32087061
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30874496
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30874496
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.30487096
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30197720
61CBP_20019798_ChIP-Seq_JUKART_Human1.30197720
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30144861
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.27802887
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.27553294
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25655761
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25297576
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24686661
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23831185
69IRF1_19129219_ChIP-ChIP_H3396_Human1.23509934
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23006161
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.17754870
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17754870
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16921413
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15506936
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10388145
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09490242
77STAT3_23295773_ChIP-Seq_U87_Human1.09489201
78SMAD4_21799915_ChIP-Seq_A2780_Human1.08349920
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.08105988
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07597285
81NCOR_22424771_ChIP-Seq_293T_Human1.07385398
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.07229494
83HTT_18923047_ChIP-ChIP_STHdh_Human1.06456108
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.06322556
85RUNX2_22187159_ChIP-Seq_PCA_Human1.06190903
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.05048154
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.04674130
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04472053
89BCAT_22108803_ChIP-Seq_LS180_Human1.04128016
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03172803
91TCF4_22108803_ChIP-Seq_LS180_Human1.02271694
92AR_20517297_ChIP-Seq_VCAP_Human1.01495029
93ELK1_19687146_ChIP-ChIP_HELA_Human1.01153770
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00607171
95TP53_22573176_ChIP-Seq_HFKS_Human0.99998171
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99954176
97E2F7_22180533_ChIP-Seq_HELA_Human0.99937300
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.98084224
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97102974
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96840087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.85704158
2MP0003136_yellow_coat_color3.49572282
3MP0003011_delayed_dark_adaptation3.01514614
4MP0005551_abnormal_eye_electrophysiolog2.55137909
5MP0004142_abnormal_muscle_tone2.51135648
6MP0008875_abnormal_xenobiotic_pharmacok2.45502765
7MP0005645_abnormal_hypothalamus_physiol2.41420299
8MP0001485_abnormal_pinna_reflex2.22845093
9MP0002736_abnormal_nociception_after2.07224549
10MP0009745_abnormal_behavioral_response2.02609218
11MP0001968_abnormal_touch/_nociception2.02488014
12MP0003195_calcinosis1.98844605
13MP0002163_abnormal_gland_morphology1.95258024
14MP0002938_white_spotting1.93534543
15MP0005646_abnormal_pituitary_gland1.93113877
16MP0006072_abnormal_retinal_apoptosis1.89571943
17MP0000631_abnormal_neuroendocrine_gland1.85416818
18MP0003880_abnormal_central_pattern1.76407850
19MP0006292_abnormal_olfactory_placode1.75145839
20MP0005379_endocrine/exocrine_gland_phen1.73856463
21MP0002653_abnormal_ependyma_morphology1.73637021
22MP0004742_abnormal_vestibular_system1.72499306
23MP0005253_abnormal_eye_physiology1.71842852
24MP0009046_muscle_twitch1.71401922
25MP0009379_abnormal_foot_pigmentation1.67893592
26MP0000569_abnormal_digit_pigmentation1.66409602
27MP0002638_abnormal_pupillary_reflex1.65832666
28MP0005423_abnormal_somatic_nervous1.63939144
29MP0003122_maternal_imprinting1.54579798
30MP0002272_abnormal_nervous_system1.53405595
31MP0002064_seizures1.48914821
32MP0000372_irregular_coat_pigmentation1.46732373
33MP0010386_abnormal_urinary_bladder1.43074103
34MP0004885_abnormal_endolymph1.42060459
35MP0003635_abnormal_synaptic_transmissio1.41692677
36MP0004147_increased_porphyrin_level1.40510363
37MP0001984_abnormal_olfaction1.40303978
38MP0008872_abnormal_physiological_respon1.39039974
39MP0002572_abnormal_emotion/affect_behav1.38796542
40MP0002557_abnormal_social/conspecific_i1.34464089
41MP0002277_abnormal_respiratory_mucosa1.34328596
42MP0003787_abnormal_imprinting1.32487651
43MP0002837_dystrophic_cardiac_calcinosis1.32112590
44MP0002067_abnormal_sensory_capabilities1.31449608
45MP0000566_synostosis1.30909444
46MP0001501_abnormal_sleep_pattern1.29893304
47MP0001986_abnormal_taste_sensitivity1.29490516
48MP0002876_abnormal_thyroid_physiology1.29203364
49MP0000026_abnormal_inner_ear1.25922224
50MP0000049_abnormal_middle_ear1.25108457
51MP0003567_abnormal_fetal_cardiomyocyte1.24587198
52MP0001486_abnormal_startle_reflex1.22226149
53MP0005195_abnormal_posterior_eye1.15863520
54MP0001881_abnormal_mammary_gland1.14740460
55MP0001905_abnormal_dopamine_level1.14252863
56MP0004133_heterotaxia1.12829705
57MP0005167_abnormal_blood-brain_barrier1.10293610
58MP0001970_abnormal_pain_threshold1.07321680
59MP0003121_genomic_imprinting1.07134827
60MP0002751_abnormal_autonomic_nervous1.06388847
61MP0002095_abnormal_skin_pigmentation1.06381583
62MP0002160_abnormal_reproductive_system1.05339733
63MP0002063_abnormal_learning/memory/cond1.04678870
64MP0005386_behavior/neurological_phenoty1.03640982
65MP0004924_abnormal_behavior1.03640982
66MP0002735_abnormal_chemical_nociception1.03284372
67MP0002752_abnormal_somatic_nervous1.02085643
68MP0005084_abnormal_gallbladder_morpholo1.01747830
69MP0006276_abnormal_autonomic_nervous1.00822568
70MP0009384_cardiac_valve_regurgitation0.99937277
71MP0003137_abnormal_impulse_conducting0.99501684
72MP0005389_reproductive_system_phenotype0.98008943
73MP0000955_abnormal_spinal_cord0.97997516
74MP0003283_abnormal_digestive_organ0.97595889
75MP0002734_abnormal_mechanical_nocicepti0.97530851
76MP0000427_abnormal_hair_cycle0.96858800
77MP0010030_abnormal_orbit_morphology0.96397282
78MP0005085_abnormal_gallbladder_physiolo0.96066111
79MP0002102_abnormal_ear_morphology0.95613834
80MP0004043_abnormal_pH_regulation0.94024395
81MP0002733_abnormal_thermal_nociception0.93498352
82MP0001529_abnormal_vocalization0.92746687
83MP0002234_abnormal_pharynx_morphology0.92643981
84MP0004215_abnormal_myocardial_fiber0.90398961
85MP0005410_abnormal_fertilization0.90099079
86MP0003938_abnormal_ear_development0.87950217
87MP0001440_abnormal_grooming_behavior0.86904168
88MP0001963_abnormal_hearing_physiology0.85751716
89MP0003119_abnormal_digestive_system0.83536994
90MP0005391_vision/eye_phenotype0.83015875
91MP0000778_abnormal_nervous_system0.82310040
92MP0005174_abnormal_tail_pigmentation0.81677552
93MP0003698_abnormal_male_reproductive0.81569071
94MP0005075_abnormal_melanosome_morpholog0.80337984
95MP0003936_abnormal_reproductive_system0.80038084
96MP0001293_anophthalmia0.78921148
97MP0001324_abnormal_eye_pigmentation0.76628886
98MP0002909_abnormal_adrenal_gland0.76550128
99MP0002184_abnormal_innervation0.76464284
100MP0001919_abnormal_reproductive_system0.76437853

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.59884595
2Agnosia (HP:0010524)4.44507062
3Type II lissencephaly (HP:0007260)3.94026076
4Congenital stationary night blindness (HP:0007642)3.68240743
5Pancreatic cysts (HP:0001737)3.65568481
6Abnormality of the pons (HP:0007361)3.58875023
7Hypoplasia of the pons (HP:0012110)3.46624234
8Cerebellar dysplasia (HP:0007033)3.45923792
9Medulloblastoma (HP:0002885)3.42797089
10Abnormality of the astrocytes (HP:0100707)3.40607925
11Astrocytoma (HP:0009592)3.40607925
12True hermaphroditism (HP:0010459)3.38744253
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.27132514
14Abnormality of alanine metabolism (HP:0010916)3.27132514
15Hyperalaninemia (HP:0003348)3.27132514
16Glioma (HP:0009733)3.20687462
17Rhabdomyosarcoma (HP:0002859)3.14882737
18Abnormality of midbrain morphology (HP:0002418)3.09131140
19Molar tooth sign on MRI (HP:0002419)3.09131140
20Pancreatic fibrosis (HP:0100732)3.02091886
21Neoplasm of the oral cavity (HP:0100649)2.89089867
22Neuroendocrine neoplasm (HP:0100634)2.88110309
23Lipid accumulation in hepatocytes (HP:0006561)2.79052671
24Atonic seizures (HP:0010819)2.75144753
25Hypothermia (HP:0002045)2.74439752
26Limb dystonia (HP:0002451)2.70437548
27Biliary tract neoplasm (HP:0100574)2.68362099
28Large for gestational age (HP:0001520)2.68073232
29Abnormal rod and cone electroretinograms (HP:0008323)2.63291842
30Nephronophthisis (HP:0000090)2.62363894
31Abnormal number of erythroid precursors (HP:0012131)2.61097994
32Absent/shortened dynein arms (HP:0200106)2.57891117
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.57891117
34Congenital, generalized hypertrichosis (HP:0004540)2.55785281
35Increased hepatocellular lipid droplets (HP:0006565)2.52468042
36Hyperventilation (HP:0002883)2.40139177
37Abnormality of the renal medulla (HP:0100957)2.37002751
38Sclerocornea (HP:0000647)2.35420635
39Neoplasm of striated muscle (HP:0009728)2.33664610
40Abnormality of cells of the erythroid lineage (HP:0012130)2.31696258
41Attenuation of retinal blood vessels (HP:0007843)2.27743231
42Abnormality of the renal cortex (HP:0011035)2.27546154
43Adenoma sebaceum (HP:0009720)2.26552753
44Angiofibromas (HP:0010615)2.26552753
45Abnormal ciliary motility (HP:0012262)2.20918866
46Abnormality of the phalanges of the 2nd finger (HP:0009541)2.20822793
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.20100314
48Reticulocytopenia (HP:0001896)2.19396040
49Neoplasm of the rectum (HP:0100743)2.19386130
50Lissencephaly (HP:0001339)2.18947570
51Mitochondrial inheritance (HP:0001427)2.12843230
52Febrile seizures (HP:0002373)2.11413156
53Duplicated collecting system (HP:0000081)2.11304896
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09555141
55Retinal dysplasia (HP:0007973)2.09472590
56Decreased central vision (HP:0007663)2.08732179
57Constricted visual fields (HP:0001133)2.07110242
58Increased CSF lactate (HP:0002490)2.06498020
59Abnormality of the labia minora (HP:0012880)2.06355122
60Abnormality of the renal collecting system (HP:0004742)2.05195744
61Abnormal respiratory epithelium morphology (HP:0012253)2.00298854
62Abnormal respiratory motile cilium morphology (HP:0005938)2.00298854
63Hepatic necrosis (HP:0002605)2.00018195
64Absent septum pellucidum (HP:0001331)1.99240882
65Increased serum ferritin (HP:0003281)1.99147892
66Abnormality of the ileum (HP:0001549)1.96544489
67Pheochromocytoma (HP:0002666)1.96229125
68Abnormality of transition element cation homeostasis (HP:0011030)1.95000441
69Acute necrotizing encephalopathy (HP:0006965)1.94946927
70Focal motor seizures (HP:0011153)1.94485864
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93855072
72Meckel diverticulum (HP:0002245)1.92867624
73Pendular nystagmus (HP:0012043)1.92840435
74Abnormal biliary tract morphology (HP:0012440)1.90778874
75Medial flaring of the eyebrow (HP:0010747)1.89502445
76Absence seizures (HP:0002121)1.89360651
77Abnormal pupillary function (HP:0007686)1.87680344
78Dialeptic seizures (HP:0011146)1.87066039
79Renal cortical cysts (HP:0000803)1.86261065
803-Methylglutaconic aciduria (HP:0003535)1.84884099
81Acute encephalopathy (HP:0006846)1.84404752
82Abnormality of the salivary glands (HP:0010286)1.83790018
83Abnormality of iron homeostasis (HP:0011031)1.83423883
84Neoplasm of the liver (HP:0002896)1.82691818
85Pachygyria (HP:0001302)1.81786867
86Supernumerary spleens (HP:0009799)1.80526332
87Glycosuria (HP:0003076)1.79004656
88Abnormality of urine glucose concentration (HP:0011016)1.79004656
89Renal Fanconi syndrome (HP:0001994)1.78571452
90Basal cell carcinoma (HP:0002671)1.78116495
91Cerebral hypomyelination (HP:0006808)1.77888650
92Abnormal respiratory motile cilium physiology (HP:0012261)1.77865830
93Cystic liver disease (HP:0006706)1.77631189
94Anencephaly (HP:0002323)1.77278175
95Gait imbalance (HP:0002141)1.76547624
96Hepatocellular necrosis (HP:0001404)1.75546758
97Increased corneal curvature (HP:0100692)1.74788613
98Keratoconus (HP:0000563)1.74788613
99Benign neoplasm of the central nervous system (HP:0100835)1.74304213
100Tubular atrophy (HP:0000092)1.73369581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.67948692
2DAPK23.01666949
3WNK32.99873390
4PAK42.94545689
5FRK2.82618085
6TLK12.78432238
7ZAK2.33009941
8WNK42.25651862
9GRK12.21632128
10MAPK132.15384475
11ADRBK22.08206174
12CASK1.97988802
13TNIK1.94902609
14PINK11.89904639
15BMPR1B1.76980813
16ACVR1B1.71055198
17PAK31.65772838
18NME11.60038408
19MARK11.58100473
20TSSK61.53390972
21NUAK11.50368253
22OXSR11.46005244
23INSRR1.32448609
24KIT1.31924695
25DYRK21.29889175
26MKNK21.29595787
27MUSK1.28943070
28VRK11.28079899
29LIMK11.26807877
30PDK21.21346914
31CCNB11.18463475
32TXK1.16907887
33STK38L1.16554248
34EIF2AK31.16313341
35MAP3K41.15138592
36TRIM281.14166333
37WEE11.13805410
38MAPK151.13553377
39TAOK31.12552160
40STK161.12214430
41MKNK11.09569905
42TGFBR11.08426097
43PNCK1.08354907
44STK391.06228832
45ADRBK11.05615515
46BCKDK1.03133825
47UHMK11.02566125
48PASK0.97423981
49SRPK10.95694768
50PRKCG0.94966675
51PRKCE0.93467058
52PLK30.93108556
53PHKG20.87583161
54PHKG10.87583161
55TAF10.84803784
56MAPKAPK50.80997197
57MAP3K120.77251870
58PIK3CA0.74483882
59AKT20.73501921
60CSNK1D0.70666067
61CAMKK20.69810857
62PLK40.69421556
63CAMK2A0.69418910
64PTK2B0.68404686
65NTRK30.63190644
66EIF2AK10.61357993
67TIE10.59909220
68DYRK1B0.59877035
69MAP2K70.57500700
70BRSK20.57069971
71CSNK1A10.53025140
72PKN10.52464223
73PRKG10.52298868
74CSNK1G20.51999696
75CSNK1G10.50376897
76STK110.49464235
77CSNK1G30.49332193
78PRKACA0.48129428
79MAPKAPK30.47416907
80PLK20.47374109
81BCR0.47162723
82FGFR20.47122153
83ROCK10.45648759
84TEC0.44197585
85CAMK1D0.43699779
86CAMK10.43408667
87RPS6KA60.42261597
88EPHA40.41690140
89CDK30.41613419
90CHEK20.41009569
91RPS6KA50.38755151
92VRK20.37659313
93OBSCN0.36796256
94PRKCA0.36381220
95IKBKB0.35618742
96EIF2AK20.35032165
97ERBB40.34858402
98PRKCI0.32022788
99CAMK2B0.32000997
100PRKAA10.31839930

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.43784558
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.10474168
3Phototransduction_Homo sapiens_hsa047443.00017276
4Parkinsons disease_Homo sapiens_hsa050122.96928588
5Ribosome_Homo sapiens_hsa030102.93827877
6Nicotine addiction_Homo sapiens_hsa050332.53061229
7Mismatch repair_Homo sapiens_hsa034302.37466430
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.31324500
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26046732
10Nitrogen metabolism_Homo sapiens_hsa009102.21885290
11Caffeine metabolism_Homo sapiens_hsa002322.14957556
12Linoleic acid metabolism_Homo sapiens_hsa005912.14212892
13Huntingtons disease_Homo sapiens_hsa050162.05306543
14Tryptophan metabolism_Homo sapiens_hsa003802.02073079
15Cardiac muscle contraction_Homo sapiens_hsa042601.98311538
16Fanconi anemia pathway_Homo sapiens_hsa034601.93932578
17Homologous recombination_Homo sapiens_hsa034401.93426752
18Alzheimers disease_Homo sapiens_hsa050101.90005053
19RNA polymerase_Homo sapiens_hsa030201.84273227
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77584175
21Protein export_Homo sapiens_hsa030601.72475221
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.70902244
23Taste transduction_Homo sapiens_hsa047421.61485326
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60809046
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.58701971
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55491412
27Butanoate metabolism_Homo sapiens_hsa006501.54730327
28Propanoate metabolism_Homo sapiens_hsa006401.54277204
29Morphine addiction_Homo sapiens_hsa050321.41661856
30Histidine metabolism_Homo sapiens_hsa003401.40785502
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32563708
32Ether lipid metabolism_Homo sapiens_hsa005651.27561238
33Pyruvate metabolism_Homo sapiens_hsa006201.27175284
34Proteasome_Homo sapiens_hsa030501.24748234
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22830520
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22607611
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18964912
38Olfactory transduction_Homo sapiens_hsa047401.16479080
39GABAergic synapse_Homo sapiens_hsa047271.15520641
40beta-Alanine metabolism_Homo sapiens_hsa004101.13847871
41Chemical carcinogenesis_Homo sapiens_hsa052040.98279365
42Basal cell carcinoma_Homo sapiens_hsa052170.96269664
43Basal transcription factors_Homo sapiens_hsa030220.95294707
44Purine metabolism_Homo sapiens_hsa002300.93406561
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93093955
46Circadian entrainment_Homo sapiens_hsa047130.86052993
47Steroid biosynthesis_Homo sapiens_hsa001000.84499063
48Serotonergic synapse_Homo sapiens_hsa047260.83535302
49Sulfur relay system_Homo sapiens_hsa041220.82469683
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80886805
51Retinol metabolism_Homo sapiens_hsa008300.80165400
52Fatty acid degradation_Homo sapiens_hsa000710.78722461
53Glutamatergic synapse_Homo sapiens_hsa047240.78666535
54Ovarian steroidogenesis_Homo sapiens_hsa049130.78661702
55Glycerolipid metabolism_Homo sapiens_hsa005610.76243596
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76014010
57Selenocompound metabolism_Homo sapiens_hsa004500.74160438
58Arachidonic acid metabolism_Homo sapiens_hsa005900.73746647
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73357708
60Pyrimidine metabolism_Homo sapiens_hsa002400.72529916
61Collecting duct acid secretion_Homo sapiens_hsa049660.70026971
62Hedgehog signaling pathway_Homo sapiens_hsa043400.66727185
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.65897487
64RNA degradation_Homo sapiens_hsa030180.60593723
65Calcium signaling pathway_Homo sapiens_hsa040200.59715190
66Metabolic pathways_Homo sapiens_hsa011000.59031418
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58160979
68Fat digestion and absorption_Homo sapiens_hsa049750.56536465
69Cocaine addiction_Homo sapiens_hsa050300.55940545
70Insulin secretion_Homo sapiens_hsa049110.54507765
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53292839
72Peroxisome_Homo sapiens_hsa041460.52964088
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52863588
74One carbon pool by folate_Homo sapiens_hsa006700.49790039
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47500013
76Non-homologous end-joining_Homo sapiens_hsa034500.47117683
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44775025
78Amphetamine addiction_Homo sapiens_hsa050310.44296570
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42661743
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.40896378
81Phenylalanine metabolism_Homo sapiens_hsa003600.40817932
82Salivary secretion_Homo sapiens_hsa049700.39235143
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38538595
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38102767
85RNA transport_Homo sapiens_hsa030130.38098984
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37717843
87Tyrosine metabolism_Homo sapiens_hsa003500.37646148
88Long-term depression_Homo sapiens_hsa047300.36019250
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34065080
90Axon guidance_Homo sapiens_hsa043600.33823079
91Mineral absorption_Homo sapiens_hsa049780.32674654
92Arginine and proline metabolism_Homo sapiens_hsa003300.31800550
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30838467
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29715981
95Vitamin B6 metabolism_Homo sapiens_hsa007500.29476145
96Nucleotide excision repair_Homo sapiens_hsa034200.27897689
97cAMP signaling pathway_Homo sapiens_hsa040240.27387673
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.26615955
99p53 signaling pathway_Homo sapiens_hsa041150.26025135
100Dopaminergic synapse_Homo sapiens_hsa047280.24980027

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