ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis I (GO:0007141)	8.27840687
2	pyrimidine nucleobase catabolic process (GO:0006208)	7.82949406
3	synapsis (GO:0007129)	7.55902882
4	synaptonemal complex assembly (GO:0007130)	7.26212153
5	chromosome organization involved in meiosis (GO:0070192)	7.01856002
6	meiosis I (GO:0007127)	6.76670408
7	piRNA metabolic process (GO:0034587)	6.60103153
8	synaptonemal complex organization (GO:0070193)	6.60011999
9	nucleobase catabolic process (GO:0046113)	6.15537174
10	DNA synthesis involved in DNA repair (GO:0000731)	5.38440210
11	DNA methylation involved in gamete generation (GO:0043046)	5.31479575
12	male meiosis (GO:0007140)	5.09864762
13	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	5.06298283
14	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	5.06298283
15	meiotic nuclear division (GO:0007126)	4.89152667
16	positive regulation of mitochondrial fission (GO:0090141)	4.88237164
17	retinal cone cell development (GO:0046549)	4.71767198
18	protein localization to cilium (GO:0061512)	4.62412386
19	leukotriene biosynthetic process (GO:0019370)	4.61511460
20	positive regulation of dendritic spine morphogenesis (GO:0061003)	4.57572286
21	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	4.49991333
22	cerebellar Purkinje cell differentiation (GO:0021702)	4.45212340
23	somite rostral/caudal axis specification (GO:0032525)	4.43790601
24	olfactory bulb development (GO:0021772)	4.39226482
25	cysteine metabolic process (GO:0006534)	4.36330065
26	meiotic cell cycle process (GO:1903046)	4.32350045
27	regulation of collateral sprouting (GO:0048670)	4.21107463
28	epithelial cilium movement (GO:0003351)	4.14760801
29	protein localization to synapse (GO:0035418)	3.92365514
30	axonal fasciculation (GO:0007413)	3.79042007
31	behavioral response to nicotine (GO:0035095)	3.76414297
32	neurotransmitter uptake (GO:0001504)	3.75042826
33	positive regulation of gastrulation (GO:2000543)	3.74634445
34	intraciliary transport (GO:0042073)	3.70621887
35	regulation of meiosis I (GO:0060631)	3.63903605
36	L-glutamate transport (GO:0015813)	3.58815274
37	reciprocal DNA recombination (GO:0035825)	3.48263043
38	reciprocal meiotic recombination (GO:0007131)	3.48263043
39	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.47621284
40	spinal cord association neuron differentiation (GO:0021527)	3.45868112
41	photoreceptor cell maintenance (GO:0045494)	3.45864109
42	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	3.43816610
43	chemosensory behavior (GO:0007635)	3.37571907
44	acidic amino acid transport (GO:0015800)	3.36693380
45	regulation of synapse structural plasticity (GO:0051823)	3.36374071
46	regulation of mitochondrial fission (GO:0090140)	3.34373137
47	retinal rod cell development (GO:0046548)	3.26696206
48	substrate-independent telencephalic tangential migration (GO:0021826)	3.25102495
49	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.25102495
50	glucose 6-phosphate metabolic process (GO:0051156)	3.22877737
51	cilium movement (GO:0003341)	3.20519162
52	retinal ganglion cell axon guidance (GO:0031290)	3.18600837
53	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	3.16218509
54	negative regulation of dendrite development (GO:2000171)	3.15069718
55	brain morphogenesis (GO:0048854)	3.14690128
56	resolution of meiotic recombination intermediates (GO:0000712)	3.13809323
57	regulation of sarcomere organization (GO:0060297)	3.13397189
58	positive regulation of RNA splicing (GO:0033120)	3.11291496
59	synaptic vesicle endocytosis (GO:0048488)	3.02885667
60	acrosome assembly (GO:0001675)	3.02356809
61	fatty acid derivative biosynthetic process (GO:1901570)	3.01268256
62	icosanoid biosynthetic process (GO:0046456)	3.01268256
63	establishment of mitochondrion localization (GO:0051654)	2.98049863
64	gene silencing by RNA (GO:0031047)	2.94288299
65	neuromuscular synaptic transmission (GO:0007274)	2.91642668
66	adult walking behavior (GO:0007628)	2.90920365
67	unsaturated fatty acid biosynthetic process (GO:0006636)	2.90777214
68	neuronal ion channel clustering (GO:0045161)	2.89541939
69	layer formation in cerebral cortex (GO:0021819)	2.87458165
70	iron-sulfur cluster assembly (GO:0016226)	2.85324414
71	metallo-sulfur cluster assembly (GO:0031163)	2.85324414
72	dendrite development (GO:0016358)	2.85079260
73	transmission of nerve impulse (GO:0019226)	2.84195283
74	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.83967344
75	detection of light stimulus involved in sensory perception (GO:0050962)	2.83448883
76	detection of light stimulus involved in visual perception (GO:0050908)	2.83448883
77	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.83114984
78	positive regulation of mitochondrial membrane permeability (GO:0035794)	2.78582751
79	glycolytic process (GO:0006096)	2.77709921
80	glycerophospholipid catabolic process (GO:0046475)	2.74900714
81	central nervous system projection neuron axonogenesis (GO:0021952)	2.73292446
82	central nervous system neuron axonogenesis (GO:0021955)	2.72823571
83	carbohydrate phosphorylation (GO:0046835)	2.71572723
84	positive regulation of cell cycle checkpoint (GO:1901978)	2.70751965
85	establishment of nucleus localization (GO:0040023)	2.67990323
86	sister chromatid cohesion (GO:0007062)	2.67713491
87	ribonucleoprotein complex disassembly (GO:0032988)	2.66163066
88	leukotriene metabolic process (GO:0006691)	2.65509082
89	photoreceptor cell development (GO:0042461)	2.63182638
90	dendrite morphogenesis (GO:0048813)	2.58699163
91	organelle disassembly (GO:1903008)	2.56607175
92	behavioral response to ethanol (GO:0048149)	2.56221329
93	histone H3-K9 demethylation (GO:0033169)	2.54444477
94	neurotransmitter-gated ion channel clustering (GO:0072578)	2.53794023
95	eye photoreceptor cell development (GO:0042462)	2.50760893
96	cell differentiation in spinal cord (GO:0021515)	2.49260460
97	regulation of mitotic spindle checkpoint (GO:1903504)	2.48568746
98	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.48568746
99	negative regulation of gene silencing (GO:0060969)	2.48263553
100	neuron recognition (GO:0008038)	2.48126327

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.54623794
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.01979902
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.53868155
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.47737288
5	TAF15_26573619_Chip-Seq_HEK293_Human	3.18317953
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.92116073
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.89839338
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.68439256
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.47522281
10	RNF2_27304074_Chip-Seq_NSC_Mouse	2.44154612
11	IRF1_19129219_ChIP-ChIP_H3396_Human	2.38043657
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30393262
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.27743788
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.27170918
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.24068730
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.07277147
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.98954133
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.98468552
19	P300_19829295_ChIP-Seq_ESCs_Human	1.90147884
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87517061
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.78337689
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.77916709
23	EWS_26573619_Chip-Seq_HEK293_Human	1.71819693
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.68500642
25	FUS_26573619_Chip-Seq_HEK293_Human	1.65695226
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.64634293
27	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.59793328
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59120595
29	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.58540386
30	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.57525471
31	VDR_22108803_ChIP-Seq_LS180_Human	1.56904785
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51134377
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.50059427
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50027246
35	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.47281950
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.45880282
37	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.44374360
38	RUNX2_22187159_ChIP-Seq_PCA_Human	1.44210041
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.42884921
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42884921
41	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.38425341
42	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.36748452
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35052153
44	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.32754360
45	STAT3_23295773_ChIP-Seq_U87_Human	1.32612211
46	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31146748
47	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.30084410
48	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.27422578
49	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.25554251
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.24207791
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23458662
52	AR_25329375_ChIP-Seq_VCAP_Human	1.23410922
53	TCF4_23295773_ChIP-Seq_U87_Human	1.18344138
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18131840
55	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15746257
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15359500
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15359500
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13775505
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12432048
60	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.11090720
61	EGR1_19032775_ChIP-ChIP_M12_Human	1.10782994
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10589823
63	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10151568
64	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.09960844
65	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.09415524
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.09046708
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07876294
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07616124
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07616124
70	NCOR_22424771_ChIP-Seq_293T_Human	1.06952353
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06949737
72	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.06096990
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.04583196
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04205793
75	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.03361302
76	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01303408
77	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.01060922
78	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00852641
79	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.00400566
80	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00159804
81	JUN_21703547_ChIP-Seq_K562_Human	0.98925061
82	TBL1_22424771_ChIP-Seq_293T_Human	0.98763851
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96820515
84	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96652588
85	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.95636732
86	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94766858
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.94580921
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93174426
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92937544
90	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.92390682
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.92115751
92	ETV1_20927104_ChIP-Seq_GIST48_Human	0.90448371
93	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.88453936
94	RBPJ_21746931_ChIP-Seq_IB4_Human	0.88342199
95	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.88089412
96	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.87861163
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87610138
98	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87267460
99	TP53_16413492_ChIP-PET_HCT116_Human	0.87082067
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87016651

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	6.03585280
2	MP0008877_abnormal_DNA_methylation	4.05347476
3	MP0006276_abnormal_autonomic_nervous	3.51073207
4	MP0002822_catalepsy	3.00868152
5	MP0004270_analgesia	2.97449156
6	MP0005423_abnormal_somatic_nervous	2.79344339
7	MP0005253_abnormal_eye_physiology	2.63598926
8	MP0001984_abnormal_olfaction	2.61433758
9	MP0002160_abnormal_reproductive_system	2.57728023
10	MP0003183_abnormal_peptide_metabolism	2.48575955
11	MP0010386_abnormal_urinary_bladder	2.48132122
12	MP0005499_abnormal_olfactory_system	2.38406130
13	MP0005394_taste/olfaction_phenotype	2.38406130
14	MP0002163_abnormal_gland_morphology	2.25485318
15	MP0000778_abnormal_nervous_system	2.23150783
16	MP0005551_abnormal_eye_electrophysiolog	2.07942225
17	MP0002254_reproductive_system_inflammat	2.03829259
18	MP0001529_abnormal_vocalization	2.01579277
19	MP0002210_abnormal_sex_determination	1.88700310
20	MP0003567_abnormal_fetal_cardiomyocyte	1.86471742
21	MP0004019_abnormal_vitamin_homeostasis	1.81763384
22	MP0008058_abnormal_DNA_repair	1.75298682
23	MP0004142_abnormal_muscle_tone	1.72752918
24	MP0006054_spinal_hemorrhage	1.72479914
25	MP0006072_abnormal_retinal_apoptosis	1.59599107
26	MP0003122_maternal_imprinting	1.58042877
27	MP0003890_abnormal_embryonic-extraembry	1.58013515
28	MP0004811_abnormal_neuron_physiology	1.57242223
29	MP0003698_abnormal_male_reproductive	1.55890108
30	MP0005389_reproductive_system_phenotype	1.53495393
31	MP0008789_abnormal_olfactory_epithelium	1.53329021
32	MP0006292_abnormal_olfactory_placode	1.49610644
33	MP0005379_endocrine/exocrine_gland_phen	1.49405727
34	MP0002752_abnormal_somatic_nervous	1.48416139
35	MP0001145_abnormal_male_reproductive	1.48351466
36	MP0005645_abnormal_hypothalamus_physiol	1.46942796
37	MP0002734_abnormal_mechanical_nocicepti	1.45651599
38	MP0001929_abnormal_gametogenesis	1.42505031
39	MP0000653_abnormal_sex_gland	1.38498922
40	MP0002882_abnormal_neuron_morphology	1.35862069
41	MP0009046_muscle_twitch	1.35052523
42	MP0002184_abnormal_innervation	1.31886906
43	MP0004742_abnormal_vestibular_system	1.29710432
44	MP0002557_abnormal_social/conspecific_i	1.29181086
45	MP0002067_abnormal_sensory_capabilities	1.26500847
46	MP0000372_irregular_coat_pigmentation	1.26393575
47	MP0002653_abnormal_ependyma_morphology	1.24554082
48	MP0002272_abnormal_nervous_system	1.23126927
49	MP0003635_abnormal_synaptic_transmissio	1.22713206
50	MP0002229_neurodegeneration	1.21118790
51	MP0000538_abnormal_urinary_bladder	1.20340704
52	MP0003121_genomic_imprinting	1.19413683
53	MP0002638_abnormal_pupillary_reflex	1.18357640
54	MP0000955_abnormal_spinal_cord	1.16663277
55	MP0002063_abnormal_learning/memory/cond	1.16645081
56	MP0008995_early_reproductive_senescence	1.15200449
57	MP0001486_abnormal_startle_reflex	1.14385379
58	MP0005195_abnormal_posterior_eye	1.11917094
59	MP0005391_vision/eye_phenotype	1.08548613
60	MP0003633_abnormal_nervous_system	1.08026351
61	MP0001485_abnormal_pinna_reflex	1.05999191
62	MP0001968_abnormal_touch/_nociception	1.04011325
63	MP0009745_abnormal_behavioral_response	1.03598946
64	MP0003221_abnormal_cardiomyocyte_apopto	1.03023133
65	MP0001119_abnormal_female_reproductive	0.99791764
66	MP0000427_abnormal_hair_cycle	0.98696093
67	MP0001756_abnormal_urination	0.95073501
68	MP0002751_abnormal_autonomic_nervous	0.93673815
69	MP0000383_abnormal_hair_follicle	0.93658242
70	MP0001970_abnormal_pain_threshold	0.92331776
71	MP0003011_delayed_dark_adaptation	0.92033613
72	MP0002161_abnormal_fertility/fecundity	0.90815635
73	MP0000569_abnormal_digit_pigmentation	0.88331595
74	MP0005386_behavior/neurological_phenoty	0.87266642
75	MP0004924_abnormal_behavior	0.87266642
76	MP0001764_abnormal_homeostasis	0.87144573
77	MP0001188_hyperpigmentation	0.86672499
78	MP0003878_abnormal_ear_physiology	0.86087097
79	MP0005377_hearing/vestibular/ear_phenot	0.86087097
80	MP0004510_myositis	0.85983155
81	MP0010678_abnormal_skin_adnexa	0.85847528
82	MP0002152_abnormal_brain_morphology	0.84179607
83	MP0002572_abnormal_emotion/affect_behav	0.83896426
84	MP0003699_abnormal_female_reproductive	0.82560743
85	MP0000631_abnormal_neuroendocrine_gland	0.80160400
86	MP0001502_abnormal_circadian_rhythm	0.79930229
87	MP0001963_abnormal_hearing_physiology	0.79551586
88	MP0008872_abnormal_physiological_respon	0.79542655
89	MP0000647_abnormal_sebaceous_gland	0.79525162
90	MP0002909_abnormal_adrenal_gland	0.78221307
91	MP0002102_abnormal_ear_morphology	0.76394798
92	MP0002837_dystrophic_cardiac_calcinosis	0.74358308
93	MP0004859_abnormal_synaptic_plasticity	0.73525923
94	MP0001919_abnormal_reproductive_system	0.72362977
95	MP0002876_abnormal_thyroid_physiology	0.71342311
96	MP0002064_seizures	0.71199160
97	MP0003631_nervous_system_phenotype	0.69880700
98	MP0003787_abnormal_imprinting	0.69336491
99	MP0006035_abnormal_mitochondrial_morpho	0.68942072
100	MP0005167_abnormal_blood-brain_barrier	0.66910676

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Central scotoma (HP:0000603)	3.96240194
2	Carpal bone hypoplasia (HP:0001498)	3.77005686
3	Impaired vibration sensation in the lower limbs (HP:0002166)	3.75131036
4	Genetic anticipation (HP:0003743)	3.74231142
5	Wrist flexion contracture (HP:0001239)	3.69859664
6	Cortical dysplasia (HP:0002539)	3.58467469
7	Abnormality of the lower motor neuron (HP:0002366)	3.58262114
8	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.42118244
9	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.42118244
10	Abnormality of the corticospinal tract (HP:0002492)	3.32331566
11	Polyphagia (HP:0002591)	3.31371465
12	Abnormality of macular pigmentation (HP:0008002)	3.21910778
13	Amblyopia (HP:0000646)	3.18935486
14	Exotropia (HP:0000577)	3.14677539
15	Intestinal atresia (HP:0011100)	3.13791100
16	Chronic hepatic failure (HP:0100626)	3.06528151
17	Nephrogenic diabetes insipidus (HP:0009806)	3.05971359
18	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.05143212
19	Bony spicule pigmentary retinopathy (HP:0007737)	3.01960124
20	Specific learning disability (HP:0001328)	3.01519698
21	Medial flaring of the eyebrow (HP:0010747)	2.98486776
22	Gait imbalance (HP:0002141)	2.94930907
23	Progressive cerebellar ataxia (HP:0002073)	2.94729896
24	Limb dystonia (HP:0002451)	2.92676223
25	Scotoma (HP:0000575)	2.91063401
26	Tubulointerstitial nephritis (HP:0001970)	2.90247485
27	Congenital primary aphakia (HP:0007707)	2.90225944
28	Vertebral arch anomaly (HP:0008438)	2.88368540
29	Anosmia (HP:0000458)	2.88340601
30	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.85102990
31	Hypoplasia of the brainstem (HP:0002365)	2.85102990
32	Agitation (HP:0000713)	2.81435468
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.79493791
34	Nephronophthisis (HP:0000090)	2.76998210
35	Lissencephaly (HP:0001339)	2.76302179
36	Amyotrophic lateral sclerosis (HP:0007354)	2.70965634
37	Hypothermia (HP:0002045)	2.69228375
38	Anomalous pulmonary venous return (HP:0010772)	2.61433712
39	Broad alveolar ridges (HP:0000187)	2.47566919
40	Supernumerary spleens (HP:0009799)	2.46819017
41	Posterior subcapsular cataract (HP:0007787)	2.46221402
42	Retinal dysplasia (HP:0007973)	2.39324905
43	Abolished electroretinogram (ERG) (HP:0000550)	2.37702158
44	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.37135453
45	Constricted visual fields (HP:0001133)	2.34424473
46	Exercise-induced muscle cramps (HP:0003710)	2.34173244
47	Congenital stationary night blindness (HP:0007642)	2.33099651
48	Urinary bladder sphincter dysfunction (HP:0002839)	2.32571634
49	Asplenia (HP:0001746)	2.29756508
50	Hip dysplasia (HP:0001385)	2.25323218
51	Spastic gait (HP:0002064)	2.24233495
52	Abnormality of the pulmonary veins (HP:0011718)	2.22933702
53	Abnormality of the fovea (HP:0000493)	2.22813216
54	Oligodactyly (hands) (HP:0001180)	2.20011512
55	Abnormal pancreas size (HP:0012094)	2.19821570
56	Impaired vibratory sensation (HP:0002495)	2.19797600
57	Abnormality of the renal medulla (HP:0100957)	2.19232556
58	Drooling (HP:0002307)	2.15042231
59	Myokymia (HP:0002411)	2.13946824
60	Abnormal rod and cone electroretinograms (HP:0008323)	2.11578431
61	Hypoplasia of the fovea (HP:0007750)	2.11474971
62	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.11474971
63	Decreased testicular size (HP:0008734)	2.09577454
64	Dyskinesia (HP:0100660)	2.05601856
65	Retinitis pigmentosa (HP:0000510)	1.99365200
66	Abnormality of the labia minora (HP:0012880)	1.99028003
67	Morphological abnormality of the pyramidal tract (HP:0002062)	1.98209352
68	Diastasis recti (HP:0001540)	1.96563068
69	Abnormality of midbrain morphology (HP:0002418)	1.95587327
70	Molar tooth sign on MRI (HP:0002419)	1.95587327
71	Widely spaced teeth (HP:0000687)	1.95296053
72	Poor coordination (HP:0002370)	1.94455444
73	Excessive salivation (HP:0003781)	1.92522873
74	Poor suck (HP:0002033)	1.92493930
75	Abnormal gallbladder physiology (HP:0012438)	1.89914942
76	Cholecystitis (HP:0001082)	1.89914942
77	Postaxial foot polydactyly (HP:0001830)	1.89782466
78	Flared iliac wings (HP:0002869)	1.87824867
79	Gonadotropin excess (HP:0000837)	1.87669183
80	Polymicrogyria (HP:0002126)	1.86646113
81	Vaginal atresia (HP:0000148)	1.85587029
82	Thickened calvaria (HP:0002684)	1.84081961
83	Tubulointerstitial abnormality (HP:0001969)	1.83632752
84	Labial hypoplasia (HP:0000066)	1.83596052
85	Uterine leiomyosarcoma (HP:0002891)	1.82999316
86	Leiomyosarcoma (HP:0100243)	1.82999316
87	Genital tract atresia (HP:0001827)	1.81076910
88	Type II diabetes mellitus (HP:0005978)	1.78742414
89	Abnormality of the labia (HP:0000058)	1.78518966
90	Micropenis (HP:0000054)	1.77305964
91	Abnormality of DNA repair (HP:0003254)	1.74815244
92	Abnormal eating behavior (HP:0100738)	1.74799802
93	Rib fusion (HP:0000902)	1.72447959
94	Attenuation of retinal blood vessels (HP:0007843)	1.72435390
95	Pancreatic cysts (HP:0001737)	1.71072092
96	Spontaneous abortion (HP:0005268)	1.70965557
97	True hermaphroditism (HP:0010459)	1.69980055
98	Preaxial hand polydactyly (HP:0001177)	1.69657504
99	Abnormality of the lumbar spine (HP:0100712)	1.68519978
100	Hand muscle atrophy (HP:0009130)	1.66578484

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.27017286
2	FRK	3.36480177
3	TRIM28	3.29791803
4	EPHA3	3.07441168
5	WNK4	3.06052575
6	CAMKK2	3.04835070
7	MAP3K4	2.83753286
8	BCKDK	2.51315527
9	BCR	2.46651755
10	DYRK3	2.45115485
11	MARK1	2.38715378
12	CASK	2.29513023
13	CDK19	2.18407434
14	MAP3K2	2.04705437
15	PLK2	1.87968191
16	SIK3	1.78104249
17	MAP3K6	1.74005958
18	PKN2	1.72050813
19	STK39	1.63451530
20	MAP2K7	1.63424938
21	DYRK1B	1.62573774
22	PDK2	1.62301217
23	FLT3	1.58001890
24	PBK	1.57847252
25	DYRK2	1.56359757
26	OXSR1	1.53487876
27	PINK1	1.47119226
28	MST4	1.46240746
29	CSNK1G2	1.35629642
30	MINK1	1.33794513
31	GRK1	1.29739149
32	EIF2AK3	1.27820119
33	CSNK1G3	1.21888210
34	CAMK4	1.16914196
35	CSNK1A1L	1.13649471
36	CSNK1G1	1.12951781
37	ERBB3	1.12888168
38	KSR1	1.11880642
39	MAP3K9	1.10734463
40	FER	0.98415689
41	RPS6KA4	0.97214029
42	UHMK1	0.97066512
43	WNK3	0.97019488
44	SRPK1	0.94416319
45	PAK3	0.93880386
46	SGK494	0.87793804
47	SGK223	0.87793804
48	ADRBK1	0.85527429
49	RET	0.83979717
50	PRKCG	0.82907782
51	CAMKK1	0.81042595
52	CAMK2A	0.78245281
53	MATK	0.74541391
54	ERBB2	0.72357751
55	STK38L	0.71785785
56	VRK1	0.71644226
57	PTK2B	0.69769500
58	PRKCE	0.69188704
59	WNK1	0.68878141
60	SGK2	0.68153890
61	LATS1	0.67761708
62	SIK2	0.66745664
63	PIK3CA	0.65228454
64	PRKCZ	0.64813451
65	TESK2	0.63722287
66	MAPK13	0.63133219
67	EPHB1	0.62048837
68	DYRK1A	0.61623333
69	MAP2K4	0.60954814
70	YES1	0.59712063
71	ICK	0.59080968
72	NTRK3	0.57589445
73	AKT2	0.57397525
74	LIMK1	0.56122893
75	DAPK2	0.51100290
76	TXK	0.50135811
77	STK16	0.50020871
78	NTRK2	0.49098091
79	RPS6KA5	0.47819626
80	CDK6	0.46721602
81	CDK5	0.44456224
82	CAMK2G	0.44043962
83	PRKAA1	0.41046292
84	BRD4	0.40675458
85	INSRR	0.40164837
86	CLK1	0.39393374
87	PRKACA	0.38852486
88	BMPR1B	0.35864545
89	TLK1	0.35553714
90	CAMK2B	0.35165773
91	MAP3K5	0.33018473
92	PLK1	0.32534351
93	ADRBK2	0.31838960
94	TNIK	0.30937372
95	STK38	0.28828730
96	NUAK1	0.28014885
97	PRKG1	0.26364522
98	CSNK1A1	0.25731935
99	ZAK	0.24918557
100	OBSCN	0.23352630

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	6.24833283
2	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.55622251
3	Nicotine addiction_Homo sapiens_hsa05033	2.62155562
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.60885529
5	Glutamatergic synapse_Homo sapiens_hsa04724	2.60536422
6	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.25274132
7	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.09729166
8	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.02513679
9	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.02232057
10	Phototransduction_Homo sapiens_hsa04744	2.00723517
11	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.00673795
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.95053951
13	GABAergic synapse_Homo sapiens_hsa04727	1.89037382
14	Axon guidance_Homo sapiens_hsa04360	1.83981248
15	Amphetamine addiction_Homo sapiens_hsa05031	1.68725666
16	Parkinsons disease_Homo sapiens_hsa05012	1.66655927
17	Steroid biosynthesis_Homo sapiens_hsa00100	1.64065592
18	Fatty acid metabolism_Homo sapiens_hsa01212	1.59683169
19	Cholinergic synapse_Homo sapiens_hsa04725	1.56302914
20	Morphine addiction_Homo sapiens_hsa05032	1.53161647
21	Regulation of autophagy_Homo sapiens_hsa04140	1.44941258
22	Taste transduction_Homo sapiens_hsa04742	1.43424477
23	Collecting duct acid secretion_Homo sapiens_hsa04966	1.42623013
24	Oocyte meiosis_Homo sapiens_hsa04114	1.42404405
25	Circadian entrainment_Homo sapiens_hsa04713	1.40282441
26	Sulfur relay system_Homo sapiens_hsa04122	1.34241343
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.29941237
28	Alcoholism_Homo sapiens_hsa05034	1.24043231
29	Gap junction_Homo sapiens_hsa04540	1.23711255
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.22841451
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20495097
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.19491624
33	Dopaminergic synapse_Homo sapiens_hsa04728	1.18599576
34	Fatty acid elongation_Homo sapiens_hsa00062	1.18388542
35	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.17083295
36	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.16571244
37	Fatty acid degradation_Homo sapiens_hsa00071	1.13531326
38	Huntingtons disease_Homo sapiens_hsa05016	1.13281987
39	Oxidative phosphorylation_Homo sapiens_hsa00190	1.07430668
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.01308213
41	Serotonergic synapse_Homo sapiens_hsa04726	0.99465857
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.99115549
43	Type II diabetes mellitus_Homo sapiens_hsa04930	0.97713559
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96983870
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.92300404
46	Long-term depression_Homo sapiens_hsa04730	0.89494615
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.89102062
48	ABC transporters_Homo sapiens_hsa02010	0.85924785
49	Insulin secretion_Homo sapiens_hsa04911	0.83938042
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.83469837
51	Olfactory transduction_Homo sapiens_hsa04740	0.83041606
52	Cocaine addiction_Homo sapiens_hsa05030	0.79843875
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.79806367
54	Basal transcription factors_Homo sapiens_hsa03022	0.79252583
55	Linoleic acid metabolism_Homo sapiens_hsa00591	0.74545436
56	Alzheimers disease_Homo sapiens_hsa05010	0.74256997
57	RNA degradation_Homo sapiens_hsa03018	0.73263783
58	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.72263533
59	Peroxisome_Homo sapiens_hsa04146	0.70156284
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69174068
61	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.66626372
62	Homologous recombination_Homo sapiens_hsa03440	0.66278199
63	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.66235764
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.64302512
65	Carbon metabolism_Homo sapiens_hsa01200	0.63627689
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63402988
67	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.62715219
68	Protein export_Homo sapiens_hsa03060	0.62196479
69	VEGF signaling pathway_Homo sapiens_hsa04370	0.62090475
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.61204343
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60355521
72	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.60124115
73	Retinol metabolism_Homo sapiens_hsa00830	0.59561414
74	Renin secretion_Homo sapiens_hsa04924	0.59308863
75	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.59189575
76	Butanoate metabolism_Homo sapiens_hsa00650	0.58684306
77	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58205309
78	Circadian rhythm_Homo sapiens_hsa04710	0.55990197
79	Tryptophan metabolism_Homo sapiens_hsa00380	0.54985943
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.54968218
81	Nucleotide excision repair_Homo sapiens_hsa03420	0.50361093
82	Propanoate metabolism_Homo sapiens_hsa00640	0.47543241
83	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46458156
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.43157047
85	Long-term potentiation_Homo sapiens_hsa04720	0.41771215
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.39395092
87	Phagosome_Homo sapiens_hsa04145	0.36751214
88	Glucagon signaling pathway_Homo sapiens_hsa04922	0.36629278
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35206324
90	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.32424461
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.29866057
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.28941329
93	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.28463733
94	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.27920776
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.25392341
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.24614265
97	RNA transport_Homo sapiens_hsa03013	0.24133076
98	Metabolic pathways_Homo sapiens_hsa01100	0.22959688
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.22773924
100	Selenocompound metabolism_Homo sapiens_hsa00450	0.22311686

KRT18P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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