ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	8.75159462
2	hair cycle (GO:0042633)	5.87941720
3	molting cycle (GO:0042303)	5.87941720
4	DNA replication-dependent nucleosome organization (GO:0034723)	5.56664008
5	DNA replication-dependent nucleosome assembly (GO:0006335)	5.56664008
6	base-excision repair, AP site formation (GO:0006285)	4.97891266
7	endocardial cushion development (GO:0003197)	4.46478438
8	atrioventricular valve morphogenesis (GO:0003181)	4.35643885
9	chemosensory behavior (GO:0007635)	4.31185851
10	ribosome assembly (GO:0042255)	4.18344776
11	pyrimidine nucleoside salvage (GO:0043097)	3.86724328
12	pyrimidine-containing compound salvage (GO:0008655)	3.86724328
13	chronic inflammatory response (GO:0002544)	3.83936168
14	regulation of transforming growth factor beta2 production (GO:0032909)	3.72699286
15	regulation of endocrine process (GO:0044060)	3.70485791
16	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.61599804
17	desmosome organization (GO:0002934)	3.56978761
18	negative regulation of fatty acid transport (GO:2000192)	3.51658357
19	focal adhesion assembly (GO:0048041)	3.46346615
20	cell-substrate adherens junction assembly (GO:0007045)	3.46346615
21	proteasome assembly (GO:0043248)	3.41857440
22	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.36637451
23	maturation of SSU-rRNA (GO:0030490)	3.29942482
24	nucleoside salvage (GO:0043174)	3.28118993
25	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.27930328
26	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	3.27630854
27	UMP biosynthetic process (GO:0006222)	3.27630854
28	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	3.27630854
29	UMP metabolic process (GO:0046049)	3.27630854
30	innate immune response in mucosa (GO:0002227)	3.23999243
31	histone-serine phosphorylation (GO:0035404)	3.23930519
32	galactose catabolic process (GO:0019388)	3.22240079
33	rRNA methylation (GO:0031167)	3.10267279
34	spliceosomal snRNP assembly (GO:0000387)	3.07986609
35	cell adhesion mediated by integrin (GO:0033627)	3.05881345
36	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.97661167
37	attachment of spindle microtubules to kinetochore (GO:0008608)	2.97195354
38	hippo signaling (GO:0035329)	2.97111236
39	wound healing, spreading of cells (GO:0044319)	2.95326581
40	muscle cell migration (GO:0014812)	2.93271403
41	regulation of histone phosphorylation (GO:0033127)	2.93155241
42	DNA deamination (GO:0045006)	2.92162042
43	rRNA modification (GO:0000154)	2.90681185
44	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.87914368
45	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.87914368
46	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.87914368
47	positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)	2.87903348
48	endocrine hormone secretion (GO:0060986)	2.84810532
49	autophagic vacuole fusion (GO:0000046)	2.84197265
50	substrate-dependent cell migration (GO:0006929)	2.84017310
51	keratinocyte development (GO:0003334)	2.80898260
52	cardiac muscle hypertrophy in response to stress (GO:0014898)	2.80826348
53	muscle hypertrophy in response to stress (GO:0003299)	2.80826348
54	cardiac muscle adaptation (GO:0014887)	2.80826348
55	myoblast migration (GO:0051451)	2.80579742
56	retina homeostasis (GO:0001895)	2.80442394
57	telomere maintenance via semi-conservative replication (GO:0032201)	2.78838072
58	positive regulation of endothelial cell apoptotic process (GO:2000353)	2.75648956
59	ventricular cardiac muscle cell development (GO:0055015)	2.75160713
60	regulation of translational termination (GO:0006449)	2.72766344
61	DNA strand elongation (GO:0022616)	2.71442813
62	DNA replication checkpoint (GO:0000076)	2.70036890
63	positive regulation of chromosome segregation (GO:0051984)	2.70016722
64	cellular response to glucose starvation (GO:0042149)	2.69360212
65	regulation of G0 to G1 transition (GO:0070316)	2.67831034
66	membrane raft organization (GO:0031579)	2.64480869
67	negative regulation of peptidyl-lysine acetylation (GO:2000757)	2.63752509
68	epithelial cell differentiation involved in kidney development (GO:0035850)	2.63462593
69	regulation of plasminogen activation (GO:0010755)	2.63246950
70	regulation of transforming growth factor beta1 production (GO:0032908)	2.62665886
71	adherens junction assembly (GO:0034333)	2.61810387
72	cardiac muscle hypertrophy (GO:0003300)	2.60808277
73	DNA strand elongation involved in DNA replication (GO:0006271)	2.58196119
74	mitotic sister chromatid segregation (GO:0000070)	2.56807773
75	negative regulation of stem cell proliferation (GO:2000647)	2.56031597
76	DNA replication initiation (GO:0006270)	2.55249671
77	nucleotide salvage (GO:0043173)	2.54879391
78	mucosal immune response (GO:0002385)	2.54075835
79	negative regulation of protein acetylation (GO:1901984)	2.53519897
80	cardiac right ventricle morphogenesis (GO:0003215)	2.51387637
81	ventricular septum development (GO:0003281)	2.50862197
82	cell-substrate junction assembly (GO:0007044)	2.48353432
83	mitotic nuclear envelope reassembly (GO:0007084)	2.47015378
84	nuclear envelope reassembly (GO:0031468)	2.47015378
85	striated muscle hypertrophy (GO:0014897)	2.45673389
86	ribosome biogenesis (GO:0042254)	2.44463186
87	antibacterial humoral response (GO:0019731)	2.44445955
88	skin morphogenesis (GO:0043589)	2.43865462
89	tRNA methylation (GO:0030488)	2.43283743
90	notochord development (GO:0030903)	2.42649590
91	folic acid metabolic process (GO:0046655)	2.42018608
92	organelle membrane fusion (GO:0090174)	2.40477754
93	response to muscle activity (GO:0014850)	2.37650572
94	regulation of hippo signaling (GO:0035330)	2.36256101
95	regulation of phospholipase A2 activity (GO:0032429)	2.35797022
96	pinocytosis (GO:0006907)	2.35435102
97	membrane tubulation (GO:0097320)	2.35081850
98	regulation of gonadotropin secretion (GO:0032276)	15.7639912
99	positive regulation of growth hormone secretion (GO:0060124)	14.0183094
100	regulation of growth hormone secretion (GO:0060123)	10.1088778

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	9.94429296
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	4.59596288
3	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	4.48922601
4	E2F7_22180533_ChIP-Seq_HELA_Human	4.34162203
5	AR_21909140_ChIP-Seq_LNCAP_Human	3.29281445
6	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.76197563
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.61156733
8	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.59862544
9	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.57632411
10	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.57632411
11	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.56137326
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.48279584
13	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.33151679
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.32365797
15	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.24742307
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.20440098
17	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.17934868
18	IRF1_19129219_ChIP-ChIP_H3396_Human	2.14002944
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.00246874
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.97404675
21	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.92792531
22	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.91559232
23	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.91393915
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.88756367
25	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.86269300
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.85809375
27	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.84478823
28	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.78483298
29	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.76077910
30	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.75768626
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.73386377
32	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.70106917
33	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.69457662
34	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.68846545
35	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.68449518
36	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.64957105
37	ATF3_27146783_Chip-Seq_COLON_Human	1.63181384
38	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.61018880
39	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.60695948
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.58317604
41	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.56250885
42	ZNF263_19887448_ChIP-Seq_K562_Human	1.54039108
43	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.47122010
44	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.46291909
45	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.44380831
46	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.43901341
47	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.41510506
48	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.40818817
49	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.34676354
50	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.32189437
51	TP53_16413492_ChIP-PET_HCT116_Human	1.30530041
52	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.28688964
53	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.28489436
54	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.28449770
55	BRD4_25478319_ChIP-Seq_HGPS_Human	1.26354072
56	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.25960569
57	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.25541762
58	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.24269374
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.23677693
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.22928664
61	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.22919263
62	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.21883450
63	ELK1_19687146_ChIP-ChIP_HELA_Human	1.18172087
64	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.17745885
65	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.17626097
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.15880306
67	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.14652299
68	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.12745473
69	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.12048024
70	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.11532653
71	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.09620549
72	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.07543622
73	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.07144666
74	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06834804
75	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.05485616
76	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.05231213
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05141118
78	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.04594064
79	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.00684429
80	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.00119326
81	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.98865773
82	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.98039137
83	VDR_23849224_ChIP-Seq_CD4+_Human	0.97528146
84	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.97186142
85	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.96005485
86	GATA4_21415370_ChIP-Seq_HL-1_Mouse	0.95474778
87	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.94120828
88	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.93392630
89	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.93115279
90	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.92985769
91	XRN2_22483619_ChIP-Seq_HELA_Human	0.92517057
92	FOXP3_21729870_ChIP-Seq_TREG_Human	0.91560315
93	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.90789638
94	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90163862
95	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.88476972
96	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.85346820
97	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.84071170
98	RACK7_27058665_Chip-Seq_MCF-7_Human	0.83006317
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.82856462
100	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.82621311

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005379_endocrine/exocrine_gland_phen	6.98159070
2	MP0001348_abnormal_lacrimal_gland	4.10853847
3	MP0010352_gastrointestinal_tract_polyps	3.64579879
4	MP0000613_abnormal_salivary_gland	3.49175407
5	MP0000647_abnormal_sebaceous_gland	3.45410725
6	MP0003950_abnormal_plasma_membrane	2.79863663
7	MP0002877_abnormal_melanocyte_morpholog	2.43767023
8	MP0010234_abnormal_vibrissa_follicle	2.43361146
9	MP0002254_reproductive_system_inflammat	2.03700684
10	MP0003806_abnormal_nucleotide_metabolis	2.02622283
11	MP0002163_abnormal_gland_morphology	11.7659257
12	MP0002132_abnormal_respiratory_system	1.86424729
13	MP0010368_abnormal_lymphatic_system	1.83751198
14	MP0001661_extended_life_span	1.81911906
15	MP0005084_abnormal_gallbladder_morpholo	1.79918464
16	MP0005670_abnormal_white_adipose	1.77790690
17	MP0001984_abnormal_olfaction	1.76095806
18	MP0003941_abnormal_skin_development	1.74115322
19	MP0005023_abnormal_wound_healing	1.66439467
20	MP0000639_abnormal_adrenal_gland	1.64548563
21	MP0003300_gastrointestinal_ulcer	1.48332704
22	MP0004272_abnormal_basement_membrane	1.41373849
23	MP0000013_abnormal_adipose_tissue	1.37348967
24	MP0000749_muscle_degeneration	1.36615199
25	MP0000462_abnormal_digestive_system	1.35907047
26	MP0003786_premature_aging	1.32849681
27	MP0003566_abnormal_cell_adhesion	1.24004451
28	MP0002138_abnormal_hepatobiliary_system	1.23886960
29	MP0010386_abnormal_urinary_bladder	1.23787753
30	MP0010094_abnormal_chromosome_stability	1.20827681
31	MP0002837_dystrophic_cardiac_calcinosis	1.19415370
32	MP0008872_abnormal_physiological_respon	1.14211943
33	MP0000750_abnormal_muscle_regeneration	1.14106404
34	MP0005330_cardiomyopathy	1.13928156
35	MP0004084_abnormal_cardiac_muscle	1.13485677
36	MP0003718_maternal_effect	1.12828036
37	MP0003111_abnormal_nucleus_morphology	1.12036862
38	MP0009697_abnormal_copulation	1.06081851
39	MP0004036_abnormal_muscle_relaxation	1.03192769
40	MP0006138_congestive_heart_failure	1.01323339
41	MP0002089_abnormal_postnatal_growth/wei	0.93287964
42	MP0000003_abnormal_adipose_tissue	0.90327430
43	MP0005083_abnormal_biliary_tract	0.88514046
44	MP0000733_abnormal_muscle_development	0.87998191
45	MP0003453_abnormal_keratinocyte_physiol	0.87391643
46	MP0004957_abnormal_blastocyst_morpholog	0.86296944
47	MP0001270_distended_abdomen	0.84920459
48	MP0002060_abnormal_skin_morphology	0.84706864
49	MP0000467_abnormal_esophagus_morphology	0.84191897
50	MP0004264_abnormal_extraembryonic_tissu	0.81450387
51	MP0010678_abnormal_skin_adnexa	0.80705754
52	MP0002108_abnormal_muscle_morphology	0.79996116
53	MP0005257_abnormal_intraocular_pressure	0.77950194
54	MP0008775_abnormal_heart_ventricle	0.76961055
55	MP0002277_abnormal_respiratory_mucosa	0.76018218
56	MP0000427_abnormal_hair_cycle	0.75970360
57	MP0003315_abnormal_perineum_morphology	0.74023742
58	MP0004087_abnormal_muscle_fiber	0.72538851
59	MP0001730_embryonic_growth_arrest	0.71739617
60	MP0003936_abnormal_reproductive_system	0.69091152
61	MP0005620_abnormal_muscle_contractility	0.68348551
62	MP0005220_abnormal_exocrine_pancreas	0.68250187
63	MP0001243_abnormal_dermal_layer	0.66116743
64	MP0008007_abnormal_cellular_replicative	0.65834368
65	MP0005503_abnormal_tendon_morphology	0.65287530
66	MP0001216_abnormal_epidermal_layer	0.64753614
67	MP0005187_abnormal_penis_morphology	0.63326529
68	MP0004233_abnormal_muscle_weight	0.58793193
69	MP0000747_muscle_weakness	0.58763079
70	MP0000751_myopathy	0.58713443
71	MP0010771_integument_phenotype	0.56370420
72	MP0004215_abnormal_myocardial_fiber	0.55575378
73	MP0008058_abnormal_DNA_repair	0.54265093
74	MP0005501_abnormal_skin_physiology	0.53934406
75	MP0000759_abnormal_skeletal_muscle	0.53875112
76	MP0008438_abnormal_cutaneous_collagen	0.53865450
77	MP0006292_abnormal_olfactory_placode	0.53819060
78	MP0005395_other_phenotype	0.52495301
79	MP0010030_abnormal_orbit_morphology	0.51597223
80	MP0005595_abnormal_vascular_smooth	0.51490682
81	MP0001191_abnormal_skin_condition	0.50853639
82	MP0000383_abnormal_hair_follicle	0.50617175
83	MP0000579_abnormal_nail_morphology	0.50530743
84	MP0009250_abnormal_appendicular_skeleto	0.50215413
85	MP0002972_abnormal_cardiac_muscle	0.48974414
86	MP0000537_abnormal_urethra_morphology	0.48609201
87	MP0002269_muscular_atrophy	0.48392277
88	MP0003279_aneurysm	0.48211580
89	MP0005369_muscle_phenotype	0.48000686
90	MP0000538_abnormal_urinary_bladder	0.47173080
91	MP0002396_abnormal_hematopoietic_system	0.47012200
92	MP0003077_abnormal_cell_cycle	0.46884579
93	MP0000377_abnormal_hair_follicle	0.46874955
94	MP0001544_abnormal_cardiovascular_syste	0.44777975
95	MP0005385_cardiovascular_system_phenoty	0.44777975
96	MP0003091_abnormal_cell_migration	0.43943938
97	MP0005508_abnormal_skeleton_morphology	0.42983429
98	MP0000762_abnormal_tongue_morphology	0.42224096
99	MP0005375_adipose_tissue_phenotype	0.42140129
100	MP0001664_abnormal_digestion	0.41836204

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rectal prolapse (HP:0002035)	6.51367471
2	Brittle hair (HP:0002299)	6.32059700
3	Hypotrichosis (HP:0001006)	5.09626068
4	Entropion (HP:0000621)	4.92184395
5	Ileus (HP:0002595)	4.65805615
6	Abnormality of the right ventricle (HP:0001707)	4.61394752
7	Anosmia (HP:0000458)	4.44735485
8	Reduced subcutaneous adipose tissue (HP:0003758)	4.42542446
9	Erythema (HP:0010783)	3.79884540
10	Bilateral sensorineural hearing impairment (HP:0008619)	3.66260169
11	Slow-growing hair (HP:0002217)	3.59658868
12	Abnormality of hair growth rate (HP:0011363)	3.59658868
13	Decreased subcutaneous fat (HP:0001002)	3.56665915
14	Aplasia cutis congenita (HP:0001057)	3.49434975
15	Aplasia of the musculature (HP:0100854)	3.48930705
16	Ureteral duplication (HP:0000073)	3.45851503
17	Aortic aneurysm (HP:0004942)	3.27790400
18	Short clavicles (HP:0000894)	3.18365223
19	Premature rupture of membranes (HP:0001788)	3.05497611
20	Abnormality of the distal phalanges of the toes (HP:0010182)	3.04095327
21	Male infertility (HP:0003251)	3.03803402
22	Breast hypoplasia (HP:0003187)	3.03297048
23	Abnormality of subcutaneous fat tissue (HP:0001001)	2.99229942
24	Rough bone trabeculation (HP:0100670)	2.94828571
25	Hypogonadotrophic hypogonadism (HP:0000044)	2.94342470
26	Azoospermia (HP:0000027)	2.91525057
27	Trismus (HP:0000211)	2.89301153
28	Gastrointestinal dysmotility (HP:0002579)	2.85834306
29	Nail dystrophy (HP:0008404)	2.80873676
30	Cutaneous melanoma (HP:0012056)	2.80113482
31	Aplasia/Hypoplasia of the scapulae (HP:0006713)	2.79803614
32	Hypoplastic scapulae (HP:0000882)	2.79803614
33	Hyperacusis (HP:0010780)	2.71257951
34	Aplasia/Hypoplasia of the clavicles (HP:0006710)	2.69381223
35	Prominent metopic ridge (HP:0005487)	2.66657994
36	Sparse lateral eyebrow (HP:0005338)	2.64813402
37	Birth length less than 3rd percentile (HP:0003561)	2.49972992
38	Self-mutilation (HP:0000742)	2.47490992
39	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.45737157
40	Glucose intolerance (HP:0000833)	2.32141716
41	Duplicated collecting system (HP:0000081)	2.32110449
42	Abnormal spermatogenesis (HP:0008669)	2.31479510
43	Partial agenesis of the corpus callosum (HP:0001338)	2.30815559
44	Upper limb amyotrophy (HP:0009129)	2.30617943
45	Distal upper limb amyotrophy (HP:0007149)	2.30617943
46	Muscle fiber inclusion bodies (HP:0100299)	2.26389395
47	Lip pit (HP:0100267)	2.24586644
48	Acute lymphatic leukemia (HP:0006721)	2.23005365
49	Right ventricular cardiomyopathy (HP:0011663)	2.16774131
50	Distal lower limb amyotrophy (HP:0008944)	2.16369414
51	Abnormality of the metopic suture (HP:0005556)	2.15461434
52	Fine hair (HP:0002213)	2.13795601
53	Natal tooth (HP:0000695)	2.09185082
54	Poikiloderma (HP:0001029)	2.07998706
55	Short nail (HP:0001799)	2.06471195
56	Achilles tendon contracture (HP:0001771)	2.06468895
57	Cardiovascular calcification (HP:0011915)	2.01849926
58	Abnormality of the renal collecting system (HP:0004742)	2.01702501
59	Abnormal trabecular bone morphology (HP:0100671)	2.01386311
60	Spastic diplegia (HP:0001264)	2.00017112
61	Microretrognathia (HP:0000308)	1.98233274
62	Aortic dissection (HP:0002647)	1.97548666
63	Vascular calcification (HP:0004934)	1.96609066
64	Abnormal biliary tract morphology (HP:0012440)	1.96497507
65	Aortic valve stenosis (HP:0001650)	1.93521746
66	EMG: myopathic abnormalities (HP:0003458)	1.90674485
67	Increased mean platelet volume (HP:0011877)	1.90542004
68	Spondylolisthesis (HP:0003302)	1.90480831
69	Submucous cleft hard palate (HP:0000176)	1.90412385
70	Aqueductal stenosis (HP:0002410)	1.87925462
71	Ventricular tachycardia (HP:0004756)	1.85752049
72	Abnormality of the calf musculature (HP:0001430)	1.85456493
73	Progressive sensorineural hearing impairment (HP:0000408)	1.84995769
74	Abnormality of methionine metabolism (HP:0010901)	1.83445636
75	Congenital, generalized hypertrichosis (HP:0004540)	1.82140066
76	Increased connective tissue (HP:0009025)	1.82038021
77	Long palpebral fissure (HP:0000637)	1.81233905
78	Abnormality of the frontal sinuses (HP:0002687)	1.79924263
79	Absent thumb (HP:0009777)	1.78726854
80	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78101673
81	Abnormality of alanine metabolism (HP:0010916)	1.78101673
82	Hyperalaninemia (HP:0003348)	1.78101673
83	Osteolytic defects of the hand bones (HP:0009699)	1.76254585
84	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.76254585
85	Abnormality of incisor morphology (HP:0011063)	1.74210584
86	Abnormality of DNA repair (HP:0003254)	1.73820203
87	Overfolded helix (HP:0000396)	1.71660066
88	Mildly elevated creatine phosphokinase (HP:0008180)	1.70989088
89	Abnormality of the columella (HP:0009929)	1.70680831
90	Abnormality of the Achilles tendon (HP:0005109)	1.70437024
91	Difficulty climbing stairs (HP:0003551)	1.69507018
92	Pulmonary artery stenosis (HP:0004415)	1.69283217
93	Muscle fiber splitting (HP:0003555)	1.67367352
94	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.66356403
95	Methylmalonic aciduria (HP:0012120)	1.65817276
96	Neck muscle weakness (HP:0000467)	1.65019294
97	Nemaline bodies (HP:0003798)	1.64927401
98	Elbow flexion contracture (HP:0002987)	1.64845020
99	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.62508010
100	Increased number of teeth (HP:0011069)	1.61524197

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LMTK2	6.61452701
2	TLK1	6.37702179
3	ZAK	5.35611899
4	EPHA2	4.75877987
5	BUB1	4.65970627
6	VRK1	2.78058164
7	AKT3	2.75576430
8	NEK1	2.66233438
9	MYLK	2.44497106
10	MST1R	2.42220773
11	SMG1	2.40120545
12	EIF2AK3	2.11161771
13	SCYL2	1.78095411
14	RPS6KB2	1.53165450
15	FLT3	1.48545384
16	STK16	1.48026616
17	NUAK1	1.47270921
18	PRKG2	1.41416802
19	AURKA	1.40854570
20	BLK	1.15382499
21	CDC7	1.06908874
22	BMPR1B	1.02371319
23	ROCK1	1.00243382
24	OBSCN	1.00104304
25	PTK2	0.99146189
26	DAPK3	0.99034229
27	FRK	0.95878307
28	MET	0.91976836
29	PTK2B	0.91204895
30	ARAF	0.86008012
31	MAPKAPK3	0.85343966
32	KDR	0.83071020
33	AURKB	0.77838421
34	TNIK	0.76545469
35	MELK	0.75647332
36	ABL2	0.74022925
37	TRPM7	0.72521222
38	VRK2	0.72020132
39	STK39	0.71644102
40	DMPK	0.70620927
41	PAK1	0.67238377
42	PHKG2	0.65954232
43	PHKG1	0.65954232
44	RPS6KA5	0.61768961
45	PKN1	0.59233918
46	EIF2AK2	0.59038771
47	PDK2	0.58263098
48	WNK4	0.57562115
49	TTN	0.55932969
50	AKT2	0.54675589
51	PAK2	0.54180130
52	CDK9	0.53830104
53	MAP2K2	0.53053063
54	PAK4	0.51597464
55	OXSR1	0.51561883
56	PINK1	0.50786461
57	PIM2	0.50470130
58	MAP3K13	0.49150223
59	PBK	0.48997528
60	ACVR1B	0.45847041
61	PTK6	0.43489253
62	LATS1	0.42959419
63	CHEK2	0.42069238
64	EIF2AK1	0.42008588
65	MOS	0.41040306
66	PRKAA1	0.40663370
67	CSNK1A1L	0.40452309
68	CDK19	0.40223944
69	MAP3K6	0.37716056
70	EEF2K	0.37423122
71	STK10	0.37408416
72	ILK	0.37133345
73	MAP2K1	0.34637928
74	TIE1	0.33182039
75	NEK2	0.33117062
76	PIM1	0.31991366
77	CSF1R	0.31901903
78	ICK	0.31583479
79	MAP3K8	0.30753759
80	KIT	0.29570437
81	WEE1	0.29304570
82	RAF1	0.28365875
83	LIMK1	0.26947056
84	NME2	0.26611425
85	MUSK	0.26364913
86	CDK12	0.22974680
87	CHUK	0.19993850
88	MAP3K3	0.19979135
89	RPS6KA4	0.19358041
90	MARK3	0.18827496
91	CHEK1	0.17664510
92	TAF1	0.16717839
93	BCKDK	0.16446393
94	MST4	0.16279638
95	CDK7	0.16072263
96	MAP2K7	0.14283215
97	TBK1	0.13328784
98	PLK1	0.13273019
99	CAMK2G	0.12783046
100	LATS2	0.12055329

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	6.37834477
2	Alcoholism_Homo sapiens_hsa05034	3.77668881
3	Proteasome_Homo sapiens_hsa03050	3.02539723
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.00490683
5	DNA replication_Homo sapiens_hsa03030	2.74159542
6	Vibrio cholerae infection_Homo sapiens_hsa05110	2.39576739
7	Viral carcinogenesis_Homo sapiens_hsa05203	2.22894771
8	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	2.16466807
9	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.15834631
10	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.12335889
11	Base excision repair_Homo sapiens_hsa03410	2.11108153
12	Spliceosome_Homo sapiens_hsa03040	2.07379405
13	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.88853698
14	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.85617842
15	Pentose phosphate pathway_Homo sapiens_hsa00030	1.79126075
16	Tight junction_Homo sapiens_hsa04530	1.73039658
17	Arginine biosynthesis_Homo sapiens_hsa00220	1.69783027
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.63177043
19	One carbon pool by folate_Homo sapiens_hsa00670	1.60459744
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.54339970
21	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.53509182
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.52093135
23	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.48691650
24	Mismatch repair_Homo sapiens_hsa03430	1.45283877
25	Renin-angiotensin system_Homo sapiens_hsa04614	1.43094903
26	Bladder cancer_Homo sapiens_hsa05219	1.37420635
27	Pancreatic secretion_Homo sapiens_hsa04972	1.35365050
28	Adherens junction_Homo sapiens_hsa04520	1.35301042
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.35229635
30	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.33107304
31	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.31205487
32	RNA transport_Homo sapiens_hsa03013	1.27982527
33	Cell cycle_Homo sapiens_hsa04110	1.27396728
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.26700827
35	RNA polymerase_Homo sapiens_hsa03020	1.24268148
36	Carbon metabolism_Homo sapiens_hsa01200	1.20881214
37	Basal transcription factors_Homo sapiens_hsa03022	1.20095731
38	Hippo signaling pathway_Homo sapiens_hsa04390	1.16886420
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.16106554
40	Focal adhesion_Homo sapiens_hsa04510	1.08219848
41	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.07455897
42	Ribosome_Homo sapiens_hsa03010	1.05150814
43	ECM-receptor interaction_Homo sapiens_hsa04512	1.01764249
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.00342666
45	RNA degradation_Homo sapiens_hsa03018	0.98869643
46	Galactose metabolism_Homo sapiens_hsa00052	0.91747078
47	Fat digestion and absorption_Homo sapiens_hsa04975	0.90531671
48	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.82841971
49	Malaria_Homo sapiens_hsa05144	0.81053610
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79944964
51	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.72757447
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.69000613
53	p53 signaling pathway_Homo sapiens_hsa04115	0.68868633
54	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.67482371
55	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.66888745
56	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.66065547
57	Other glycan degradation_Homo sapiens_hsa00511	0.63534416
58	Apoptosis_Homo sapiens_hsa04210	0.62232681
59	Purine metabolism_Homo sapiens_hsa00230	0.60548202
60	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.60301665
61	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58769636
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.58272414
63	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.56754369
64	Thyroid cancer_Homo sapiens_hsa05216	0.51495590
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.51475228
66	Protein digestion and absorption_Homo sapiens_hsa04974	0.50374180
67	Huntingtons disease_Homo sapiens_hsa05016	0.50154473
68	Small cell lung cancer_Homo sapiens_hsa05222	0.47871572
69	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.47847928
70	Fatty acid elongation_Homo sapiens_hsa00062	0.46644869
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45633402
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.43185385
73	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.42433429
74	Phenylalanine metabolism_Homo sapiens_hsa00360	0.41976808
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41191838
76	Glutathione metabolism_Homo sapiens_hsa00480	0.40720142
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40309160
78	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.40207219
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38290645
80	ABC transporters_Homo sapiens_hsa02010	0.37307183
81	Oocyte meiosis_Homo sapiens_hsa04114	0.36304106
82	Gap junction_Homo sapiens_hsa04540	0.35732876
83	Shigellosis_Homo sapiens_hsa05131	0.34726163
84	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34533675
85	Sulfur relay system_Homo sapiens_hsa04122	0.34092859
86	Oxidative phosphorylation_Homo sapiens_hsa00190	0.33111410
87	Parkinsons disease_Homo sapiens_hsa05012	0.32460928
88	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.31733531
89	Gastric acid secretion_Homo sapiens_hsa04971	0.31525287
90	Homologous recombination_Homo sapiens_hsa03440	0.30581918
91	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.30229965
92	Melanoma_Homo sapiens_hsa05218	0.30044327
93	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.29474024
94	Tryptophan metabolism_Homo sapiens_hsa00380	0.29242804
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28990072
96	Calcium signaling pathway_Homo sapiens_hsa04020	0.28526367
97	Proteoglycans in cancer_Homo sapiens_hsa05205	0.27022035
98	mRNA surveillance pathway_Homo sapiens_hsa03015	0.24202467
99	Chemical carcinogenesis_Homo sapiens_hsa05204	0.23499838
100	Metabolic pathways_Homo sapiens_hsa01100	0.20311201

KRT18P60

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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