KRT18P61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ether lipid metabolic process (GO:0046485)8.29248765
2tolerance induction (GO:0002507)7.22135351
3monoubiquitinated protein deubiquitination (GO:0035520)6.87127618
4activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO6.47554032
5glycerol ether metabolic process (GO:0006662)6.37251944
6ether metabolic process (GO:0018904)5.96644639
7rRNA methylation (GO:0031167)5.79576785
8rRNA modification (GO:0000154)5.03487327
9nonmotile primary cilium assembly (GO:0035058)4.90557839
10cellular response to interleukin-15 (GO:0071350)4.85605191
11histone H4-K12 acetylation (GO:0043983)4.66848569
12left/right axis specification (GO:0070986)4.51416751
13nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.48912896
14somite development (GO:0061053)4.46943753
15regulation of memory T cell differentiation (GO:0043380)4.40633166
16protein K63-linked deubiquitination (GO:0070536)4.33258949
17aspartate family amino acid biosynthetic process (GO:0009067)4.32053066
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.24888887
19cardiolipin metabolic process (GO:0032048)4.22184898
20regulation of RNA export from nucleus (GO:0046831)4.20900283
21positive regulation of pseudopodium assembly (GO:0031274)4.19330767
22substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.01157940
23substrate-independent telencephalic tangential migration (GO:0021826)4.01157940
24adaptation of signaling pathway (GO:0023058)3.98017425
25lateral ventricle development (GO:0021670)3.97915376
26serine family amino acid catabolic process (GO:0009071)3.90362998
27regulation of mitotic spindle checkpoint (GO:1903504)3.85627671
28regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.85627671
29regulation of pseudopodium assembly (GO:0031272)3.80814832
30DNA deamination (GO:0045006)3.79334499
31protein peptidyl-prolyl isomerization (GO:0000413)3.71372821
32regulation of regulatory T cell differentiation (GO:0045589)3.70071020
33positive regulation of defense response to virus by host (GO:0002230)3.68854452
34L-serine metabolic process (GO:0006563)3.62537863
35protein localization to Golgi apparatus (GO:0034067)3.61429192
36hormone catabolic process (GO:0042447)3.46328066
37execution phase of apoptosis (GO:0097194)3.40128284
38neural tube formation (GO:0001841)3.40057221
39regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.38553805
40histone H4-K8 acetylation (GO:0043982)3.38397677
41histone H4-K5 acetylation (GO:0043981)3.38397677
42intra-S DNA damage checkpoint (GO:0031573)3.34535773
43response to interleukin-15 (GO:0070672)3.34437676
44histone H4-K16 acetylation (GO:0043984)3.27838058
45S-adenosylmethionine metabolic process (GO:0046500)3.26764705
46homocysteine metabolic process (GO:0050667)3.22292597
47hematopoietic stem cell differentiation (GO:0060218)3.21531536
48regulation of establishment of cell polarity (GO:2000114)3.17574327
49regulation of histone H3-K4 methylation (GO:0051569)3.14079956
50leukocyte aggregation (GO:0070486)3.11848026
51folic acid metabolic process (GO:0046655)3.00241713
52cellular response to nicotine (GO:0071316)2.97430742
53histone H2A monoubiquitination (GO:0035518)2.96408111
54signal peptide processing (GO:0006465)2.94521064
55positive regulation of histone deacetylation (GO:0031065)2.93803917
56regulation of nucleobase-containing compound transport (GO:0032239)2.87891678
57negative regulation of protein localization to cell surface (GO:2000009)2.87014582
58epithelial cilium movement (GO:0003351)2.84334633
59intracellular lipid transport (GO:0032365)2.84226541
60negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.83863894
61positive regulation of histone H3-K4 methylation (GO:0051571)2.83461110
62replication fork processing (GO:0031297)2.82707489
63histone H2A ubiquitination (GO:0033522)2.81574964
64kynurenine metabolic process (GO:0070189)2.81079068
65indolalkylamine metabolic process (GO:0006586)2.76727652
66axoneme assembly (GO:0035082)2.75768923
67positive regulation of tolerance induction (GO:0002645)2.75509588
68L-fucose catabolic process (GO:0042355)2.74354327
69fucose catabolic process (GO:0019317)2.74354327
70L-fucose metabolic process (GO:0042354)2.74354327
71negative regulation of systemic arterial blood pressure (GO:0003085)2.73503372
72mast cell degranulation (GO:0043303)2.69800608
73mast cell activation involved in immune response (GO:0002279)2.69800608
74negative regulation of B cell activation (GO:0050869)2.67201452
75peptidyl-proline modification (GO:0018208)2.66839655
76regulation of establishment or maintenance of cell polarity (GO:0032878)2.66220717
77retinal rod cell development (GO:0046548)2.61313322
78behavioral response to nicotine (GO:0035095)2.59155692
79positive regulation of prostaglandin secretion (GO:0032308)2.58712259
80histone H3-K4 trimethylation (GO:0080182)2.52019137
81double-strand break repair via nonhomologous end joining (GO:0006303)2.51631632
82non-recombinational repair (GO:0000726)2.51631632
83glutamine metabolic process (GO:0006541)2.50193936
84hyaluronan catabolic process (GO:0030214)2.49340405
85protein-cofactor linkage (GO:0018065)2.48836837
86embryonic hemopoiesis (GO:0035162)2.48722448
87regulation of hydrogen peroxide metabolic process (GO:0010310)2.48012418
88inner mitochondrial membrane organization (GO:0007007)2.47123982
89fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.46794389
90preassembly of GPI anchor in ER membrane (GO:0016254)2.46093256
91negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.43437801
92regulation of defense response to virus by host (GO:0050691)2.43209229
93cellular ketone body metabolic process (GO:0046950)2.42900949
94negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.42873728
95hepatocyte apoptotic process (GO:0097284)2.41481584
96response to UV-B (GO:0010224)2.40933204
97indole-containing compound catabolic process (GO:0042436)2.40690738
98indolalkylamine catabolic process (GO:0046218)2.40690738
99tryptophan catabolic process (GO:0006569)2.40690738
100protein-chromophore linkage (GO:0018298)2.40337412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.07341897
2FLI1_27457419_Chip-Seq_LIVER_Mouse2.97701020
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.80663898
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.74229471
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68547989
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.65426436
7VDR_22108803_ChIP-Seq_LS180_Human2.52111191
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44991235
9IRF1_19129219_ChIP-ChIP_H3396_Human2.43778864
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43179716
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.30261706
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20132487
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10302071
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03189217
15CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02933365
16PCGF2_27294783_Chip-Seq_NPCs_Mouse1.96645869
17EZH2_22144423_ChIP-Seq_EOC_Human1.94055303
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88997023
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.87069127
20VDR_23849224_ChIP-Seq_CD4+_Human1.79034562
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77613719
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72776721
23TP53_22573176_ChIP-Seq_HFKS_Human1.70146700
24ER_23166858_ChIP-Seq_MCF-7_Human1.69829856
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.68593872
26ELK1_19687146_ChIP-ChIP_HELA_Human1.67384879
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.66941525
28MYC_18940864_ChIP-ChIP_HL60_Human1.66435506
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.65899026
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65322369
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.60969035
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53787944
33FOXA1_21572438_ChIP-Seq_LNCaP_Human1.50939324
34P300_19829295_ChIP-Seq_ESCs_Human1.45082199
35STAT3_23295773_ChIP-Seq_U87_Human1.42491326
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41767030
37IGF1R_20145208_ChIP-Seq_DFB_Human1.37700788
38PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.31645965
39EGR1_19032775_ChIP-ChIP_M12_Human1.31326402
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31232231
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.30819476
42FOXH1_21741376_ChIP-Seq_EPCs_Human1.30315170
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29097399
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28145438
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27753714
46ETV1_20927104_ChIP-Seq_GIST48_Human1.27220514
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26078426
48RBPJ_21746931_ChIP-Seq_IB4_Human1.25931484
49PHF8_20622853_ChIP-Seq_HELA_Human1.25917608
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.25621345
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25621345
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24250505
53GATA6_21074721_ChIP-Seq_CACO-2_Human1.23256663
54NFYB_21822215_ChIP-Seq_K562_Human1.21601641
55GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.20844626
56NCOR_22424771_ChIP-Seq_293T_Human1.19993389
57TTF2_22483619_ChIP-Seq_HELA_Human1.19921477
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.19438383
59TCF4_22108803_ChIP-Seq_LS180_Human1.18991747
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18908146
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17329293
62LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16308163
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15900691
64P53_22387025_ChIP-Seq_ESCs_Mouse1.15302163
65HNFA_21074721_ChIP-Seq_CACO-2_Human1.15155964
66TCF4_23295773_ChIP-Seq_U87_Human1.14318945
67HTT_18923047_ChIP-ChIP_STHdh_Human1.13695202
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13565598
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.13430147
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13392865
71CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13111298
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12784020
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.12213229
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10080636
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09997330
76SMAD4_21799915_ChIP-Seq_A2780_Human1.09942824
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.09848914
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09591328
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09533739
80AR_25329375_ChIP-Seq_VCAP_Human1.09186861
81P300_18555785_Chip-Seq_ESCs_Mouse1.06810124
82GATA3_21878914_ChIP-Seq_MCF-7_Human1.06662039
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.05606425
84AR_20517297_ChIP-Seq_VCAP_Human1.05269288
85RUNX_20019798_ChIP-Seq_JUKART_Human1.04936190
86TAF15_26573619_Chip-Seq_HEK293_Human1.04722326
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04384020
88ZNF263_19887448_ChIP-Seq_K562_Human1.04006831
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03475239
90NANOG_19829295_ChIP-Seq_ESCs_Human1.03469197
91SOX2_19829295_ChIP-Seq_ESCs_Human1.03469197
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03153150
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.01498286
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00990789
95MYB_26560356_Chip-Seq_TH2_Human1.00719023
96IRF8_21731497_ChIP-ChIP_J774_Mouse1.00645750
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00231451
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00095225
99CMYC_18555785_Chip-Seq_ESCs_Mouse0.99899452
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.99352661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001661_extended_life_span4.03729139
2MP0003136_yellow_coat_color3.69837867
3MP0005083_abnormal_biliary_tract3.31032199
4MP0003300_gastrointestinal_ulcer3.13856483
5MP0000569_abnormal_digit_pigmentation3.01803706
6MP0005171_absent_coat_pigmentation2.95926981
7MP0001542_abnormal_bone_strength2.90363536
8MP0005174_abnormal_tail_pigmentation2.57697757
9MP0002254_reproductive_system_inflammat2.43152623
10MP0009333_abnormal_splenocyte_physiolog2.34951400
11MP0003786_premature_aging2.19627917
12MP0002638_abnormal_pupillary_reflex2.14158540
13MP0006292_abnormal_olfactory_placode2.14064873
14MP0004147_increased_porphyrin_level2.10222538
15MP0001873_stomach_inflammation2.10215661
16MP0001835_abnormal_antigen_presentation2.08208035
17MP0005365_abnormal_bile_salt2.01779703
18MP0002163_abnormal_gland_morphology1.96230864
19MP0003806_abnormal_nucleotide_metabolis1.95056846
20MP0005310_abnormal_salivary_gland1.87965512
21MP0000685_abnormal_immune_system1.86645433
22MP0002876_abnormal_thyroid_physiology1.84363322
23MP0001502_abnormal_circadian_rhythm1.80245151
24MP0003195_calcinosis1.79482817
25MP0004381_abnormal_hair_follicle1.78187739
26MP0006035_abnormal_mitochondrial_morpho1.77801489
27MP0003011_delayed_dark_adaptation1.72471472
28MP0005085_abnormal_gallbladder_physiolo1.68670024
29MP0008057_abnormal_DNA_replication1.66382076
30MP0002095_abnormal_skin_pigmentation1.58310268
31MP0004043_abnormal_pH_regulation1.55024551
32MP0005330_cardiomyopathy1.48440683
33MP0005671_abnormal_response_to1.41322640
34MP0005551_abnormal_eye_electrophysiolog1.41220573
35MP0003763_abnormal_thymus_physiology1.37970525
36MP0006036_abnormal_mitochondrial_physio1.36974511
37MP0010155_abnormal_intestine_physiology1.36756420
38MP0000427_abnormal_hair_cycle1.36752505
39MP0006072_abnormal_retinal_apoptosis1.34631870
40MP0003787_abnormal_imprinting1.32994245
41MP0001529_abnormal_vocalization1.32520944
42MP0003866_abnormal_defecation1.24781634
43MP0001348_abnormal_lacrimal_gland1.23623454
44MP0005253_abnormal_eye_physiology1.23554664
45MP0001986_abnormal_taste_sensitivity1.21553503
46MP0009764_decreased_sensitivity_to1.18791283
47MP0005379_endocrine/exocrine_gland_phen1.17220459
48MP0001293_anophthalmia1.14310822
49MP0000647_abnormal_sebaceous_gland1.13826285
50MP0004883_abnormal_blood_vessel1.13421821
51MP0008058_abnormal_DNA_repair1.11151840
52MP0001501_abnormal_sleep_pattern1.08585985
53MP0008875_abnormal_xenobiotic_pharmacok1.05418924
54MP0000015_abnormal_ear_pigmentation1.02499463
55MP0006276_abnormal_autonomic_nervous1.02484737
56MP0005084_abnormal_gallbladder_morpholo0.99558681
57MP0001800_abnormal_humoral_immune0.99462547
58MP0000703_abnormal_thymus_morphology0.99154243
59MP0003252_abnormal_bile_duct0.94683016
60MP0002138_abnormal_hepatobiliary_system0.90784758
61MP0003567_abnormal_fetal_cardiomyocyte0.90670885
62MP0002736_abnormal_nociception_after0.90423527
63MP0005075_abnormal_melanosome_morpholog0.88202706
64MP0000383_abnormal_hair_follicle0.87699545
65MP0003959_abnormal_lean_body0.86308353
66MP0006054_spinal_hemorrhage0.85118658
67MP0003121_genomic_imprinting0.84404490
68MP0009765_abnormal_xenobiotic_induced0.84367906
69MP0001984_abnormal_olfaction0.83865393
70MP0003718_maternal_effect0.83745600
71MP0009379_abnormal_foot_pigmentation0.83418611
72MP0008873_increased_physiological_sensi0.82243334
73MP0008995_early_reproductive_senescence0.81831413
74MP0000613_abnormal_salivary_gland0.81738712
75MP0002396_abnormal_hematopoietic_system0.80408742
76MP0002928_abnormal_bile_duct0.79550220
77MP0001666_abnormal_nutrient_absorption0.78688438
78MP0003646_muscle_fatigue0.76781279
79MP0001919_abnormal_reproductive_system0.76280801
80MP0005167_abnormal_blood-brain_barrier0.72847744
81MP0005645_abnormal_hypothalamus_physiol0.70440429
82MP0001191_abnormal_skin_condition0.70187717
83MP0004019_abnormal_vitamin_homeostasis0.70068165
84MP0005389_reproductive_system_phenotype0.69708382
85MP0002452_abnormal_antigen_presenting0.68417322
86MP0005636_abnormal_mineral_homeostasis0.68370962
87MP0002067_abnormal_sensory_capabilities0.68031479
88MP0001270_distended_abdomen0.67443857
89MP0003186_abnormal_redox_activity0.67089129
90MP0002272_abnormal_nervous_system0.66868448
91MP0005408_hypopigmentation0.66793363
92MP0003936_abnormal_reproductive_system0.66746143
93MP0009745_abnormal_behavioral_response0.66737677
94MP0001853_heart_inflammation0.66657245
95MP0003868_abnormal_feces_composition0.65777497
96MP0005319_abnormal_enzyme/_coenzyme0.64761805
97MP0001790_abnormal_immune_system0.63770021
98MP0005387_immune_system_phenotype0.63770021
99MP0008872_abnormal_physiological_respon0.63673640
100MP0000358_abnormal_cell_content/0.63392556

Predicted human phenotypes

RankGene SetZ-score
1Entropion (HP:0000621)7.32506363
2Congenital, generalized hypertrichosis (HP:0004540)5.54466949
3Glucose intolerance (HP:0000833)5.29517272
4Insulin-resistant diabetes mellitus (HP:0000831)4.73565430
5Ulnar deviation of the wrist (HP:0003049)4.35046881
6Overlapping toe (HP:0001845)4.19436937
7Large for gestational age (HP:0001520)4.14833828
8Abnormality of the distal phalanges of the toes (HP:0010182)4.05958675
9Hyperglycemia (HP:0003074)4.02032276
10Adrenal hypoplasia (HP:0000835)4.01469854
11Short nail (HP:0001799)3.97386563
12Abnormal glucose tolerance (HP:0001952)3.84070794
13Pancreatic islet-cell hyperplasia (HP:0004510)3.65470284
14Abnormality of midbrain morphology (HP:0002418)3.60970253
15Molar tooth sign on MRI (HP:0002419)3.60970253
16Reduced subcutaneous adipose tissue (HP:0003758)3.55312855
17Abnormality of macular pigmentation (HP:0008002)3.54891076
18Prominent metopic ridge (HP:0005487)3.37321443
19Ureteral duplication (HP:0000073)3.32898180
20Premature rupture of membranes (HP:0001788)3.27283777
21Recurrent cutaneous fungal infections (HP:0011370)3.12419365
22Chronic mucocutaneous candidiasis (HP:0002728)3.12419365
23Abnormality of the metopic suture (HP:0005556)3.05642836
24Natal tooth (HP:0000695)2.80339975
25Short humerus (HP:0005792)2.79187131
26Patchy hypopigmentation of hair (HP:0011365)2.74098293
27Facial hemangioma (HP:0000329)2.72351152
28True hermaphroditism (HP:0010459)2.68886884
29Abnormality of homocysteine metabolism (HP:0010919)2.66581501
30Homocystinuria (HP:0002156)2.66581501
31Aplasia/hypoplasia of the humerus (HP:0006507)2.60599445
32Rough bone trabeculation (HP:0100670)2.58390651
33Rhizomelia (HP:0008905)2.55134638
34Abnormality of the umbilical cord (HP:0010881)2.52028869
35Central scotoma (HP:0000603)2.50723209
36Resting tremor (HP:0002322)2.48034257
37Broad alveolar ridges (HP:0000187)2.45575768
38Epiphyseal stippling (HP:0010655)2.43525516
39Exotropia (HP:0000577)2.41493340
40Poikiloderma (HP:0001029)2.32912436
41Villous atrophy (HP:0011473)2.31757320
42Abnormality of small intestinal villus morphology (HP:0011472)2.31757320
43Sparse eyelashes (HP:0000653)2.31437208
44Brittle hair (HP:0002299)2.29712870
45Thyroiditis (HP:0100646)2.29410749
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.28665710
47Hyperinsulinemic hypoglycemia (HP:0000825)2.23188805
48Severe combined immunodeficiency (HP:0004430)2.19296894
49Abnormality of eosinophils (HP:0001879)2.18603406
50Albinism (HP:0001022)2.10766261
51Deep palmar crease (HP:0006191)2.10584150
52Cutaneous melanoma (HP:0012056)2.10502252
53Osteolytic defects of the hand bones (HP:0009699)2.09862354
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.09862354
55Rib fusion (HP:0000902)2.09101189
56Abnormal trabecular bone morphology (HP:0100671)2.08305646
57Submucous cleft hard palate (HP:0000176)10.6477427
58Aplasia/hypoplasia of the femur (HP:0005613)1.98512323
59Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98314524
60Degeneration of the lateral corticospinal tracts (HP:0002314)1.98314524
61Wide intermamillary distance (HP:0006610)1.98102639
62Agammaglobulinemia (HP:0004432)1.97534595
63Abnormality of DNA repair (HP:0003254)1.96882497
64Gaze-evoked nystagmus (HP:0000640)1.93630005
65Shawl scrotum (HP:0000049)1.91210297
66Abnormal rod and cone electroretinograms (HP:0008323)1.87895530
67Attenuation of retinal blood vessels (HP:0007843)1.86592820
68Stillbirth (HP:0003826)1.85865807
69Stomatitis (HP:0010280)1.84948024
70Abnormality of the pancreatic islet cells (HP:0006476)1.83773729
71Abnormality of endocrine pancreas physiology (HP:0012093)1.83773729
72Panhypogammaglobulinemia (HP:0003139)1.83261281
73Lack of skin elasticity (HP:0100679)1.82935177
74Febrile seizures (HP:0002373)1.82766345
75Narrow forehead (HP:0000341)1.80574396
76Broad palm (HP:0001169)1.79358516
77Abnormal epiphyseal ossification (HP:0010656)1.77374892
78Highly arched eyebrow (HP:0002553)1.73084578
79Pancreatic fibrosis (HP:0100732)1.72717762
80Sacral dimple (HP:0000960)1.70386486
81Lipid accumulation in hepatocytes (HP:0006561)1.67123438
82Decreased electroretinogram (ERG) amplitude (HP:0000654)1.62992290
83Decreased central vision (HP:0007663)1.62749337
84Pancreatic cysts (HP:0001737)1.62703416
85Congenital stationary night blindness (HP:0007642)1.61709361
86Decreased skull ossification (HP:0004331)1.61254473
87Encephalitis (HP:0002383)1.60344394
88Severe visual impairment (HP:0001141)1.58921480
89Hand muscle atrophy (HP:0009130)1.57797017
90Ileus (HP:0002595)1.57732332
91Short palpebral fissure (HP:0012745)1.57264620
92Rhinitis (HP:0012384)1.56479263
93Oculomotor apraxia (HP:0000657)1.54784407
94Colon cancer (HP:0003003)1.53916622
95Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.53588723
96Insulin resistance (HP:0000855)1.53400646
97Hypoplastic toenails (HP:0001800)1.53089842
98Dysmetric saccades (HP:0000641)1.52847147
99Tented upper lip vermilion (HP:0010804)1.52086456
100Supernumerary nipples (HP:0002558)1.51011733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.46690368
2TXK3.70153200
3PDK22.77921901
4EIF2AK12.72485685
5TAOK32.68799995
6TGFBR22.68421959
7CSNK1G22.63106161
8EPHB22.59350555
9ADRBK22.56680290
10MAP3K122.47777389
11FRK2.38179636
12PLK22.18942965
13STK392.07409469
14CAMK1D2.05397042
15NEK12.04688818
16PAK31.90872361
17WNK41.89605010
18CAMKK21.68147902
19NUAK11.64084049
20EIF2AK31.55765117
21CAMK1G1.50680355
22PBK1.41840058
23IKBKE1.36915382
24TLK11.35560259
25PRKD31.31533691
26STK101.30618416
27FGFR11.28706197
28BCR1.24806029
29OXSR11.19940046
30GRK11.16886694
31NTRK21.16479456
32FER1.16075804
33CSNK1G11.14122633
34TEC1.13268287
35MUSK1.11278803
36PRKD21.11187164
37CSNK1G31.05794328
38BCKDK1.05026767
39MKNK11.04551287
40PRKCI1.00908638
41TAF10.99663218
42CSNK1A1L0.97875267
43MARK30.97361990
44TIE10.89929840
45GRK60.88163212
46PRKD10.86449858
47MAP4K10.83245241
48PRKCE0.83221919
49STK380.81728418
50MAP3K110.77825745
51ADRBK10.77284761
52CAMK10.76518404
53GRK70.75720321
54STK38L0.72749596
55MAP3K40.70825135
56STK40.70664726
57PIM20.69969275
58TNIK0.69227883
59AKT30.69025315
60PRKCQ0.68506201
61PTK2B0.67870552
62MAPK130.67210336
63CLK10.67154560
64PASK0.64652109
65IKBKB0.62939086
66EPHA40.62646885
67CAMK40.57476809
68CAMK2A0.56189899
69MST40.56049679
70CAMK2D0.54565865
71MAP2K70.54422434
72MATK0.51283285
73GRK50.49703012
74WNK10.49051248
75LRRK20.46563441
76NEK60.43124974
77LCK0.37865766
78OBSCN0.37104725
79CAMKK10.36790727
80TBK10.36690843
81CSNK1D0.35794989
82WNK30.34206276
83PRKAA20.33445164
84PRKCH0.32562580
85PRKACA0.32530834
86PINK10.31408141
87PRKCA0.30533566
88RPS6KA60.30400869
89PLK30.29713481
90EGFR0.29114531
91BTK0.27949924
92CHEK10.25401330
93SIK20.24460006
94MINK10.24263642
95ATM0.23312493
96CSNK1E0.22751484
97ROCK20.22588009
98TGFBR10.22376998
99MYLK0.21732794
100STK110.20833897

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.92312274
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.25342139
3Ether lipid metabolism_Homo sapiens_hsa005652.94223762
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.80091419
5One carbon pool by folate_Homo sapiens_hsa006702.77041453
6RNA degradation_Homo sapiens_hsa030182.72463556
7Proteasome_Homo sapiens_hsa030502.60094702
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56648861
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28134687
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25860005
11Non-homologous end-joining_Homo sapiens_hsa034502.20203138
12Peroxisome_Homo sapiens_hsa041462.19570673
13Phototransduction_Homo sapiens_hsa047442.17558490
14Sulfur relay system_Homo sapiens_hsa041222.14454259
15Propanoate metabolism_Homo sapiens_hsa006402.10336394
16Primary immunodeficiency_Homo sapiens_hsa053402.09429094
17Glycosaminoglycan degradation_Homo sapiens_hsa005312.08579370
18Steroid biosynthesis_Homo sapiens_hsa001001.92733782
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80381862
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64067494
21Parkinsons disease_Homo sapiens_hsa050121.61388671
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55187793
23Circadian rhythm_Homo sapiens_hsa047101.53727741
24Oxidative phosphorylation_Homo sapiens_hsa001901.51310346
25Alzheimers disease_Homo sapiens_hsa050101.49201954
26Linoleic acid metabolism_Homo sapiens_hsa005911.46882018
27Protein export_Homo sapiens_hsa030601.40466680
28Nitrogen metabolism_Homo sapiens_hsa009101.35020720
29beta-Alanine metabolism_Homo sapiens_hsa004101.32374851
30Mineral absorption_Homo sapiens_hsa049781.24518633
31Butanoate metabolism_Homo sapiens_hsa006501.23032918
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20555355
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09115537
34Tryptophan metabolism_Homo sapiens_hsa003801.08748797
35Huntingtons disease_Homo sapiens_hsa050161.08553320
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06180298
37Fatty acid metabolism_Homo sapiens_hsa012121.05839919
38Fatty acid degradation_Homo sapiens_hsa000711.04541445
39Regulation of autophagy_Homo sapiens_hsa041401.01927284
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01880452
41Ribosome_Homo sapiens_hsa030100.99149968
42Legionellosis_Homo sapiens_hsa051340.93884695
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93244385
44Fatty acid biosynthesis_Homo sapiens_hsa000610.93209055
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93044253
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91495609
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88729466
48Pyruvate metabolism_Homo sapiens_hsa006200.87599455
49Retinol metabolism_Homo sapiens_hsa008300.87017848
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83530670
51Olfactory transduction_Homo sapiens_hsa047400.82045318
52Histidine metabolism_Homo sapiens_hsa003400.75485915
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73904088
54Insulin secretion_Homo sapiens_hsa049110.69139723
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68481620
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.66727258
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63873811
58Fanconi anemia pathway_Homo sapiens_hsa034600.62867010
59Metabolic pathways_Homo sapiens_hsa011000.62111689
60Cardiac muscle contraction_Homo sapiens_hsa042600.61452881
61Chemical carcinogenesis_Homo sapiens_hsa052040.60851529
62Glycerolipid metabolism_Homo sapiens_hsa005610.59722924
63Spliceosome_Homo sapiens_hsa030400.59414656
64Antigen processing and presentation_Homo sapiens_hsa046120.56260054
65Folate biosynthesis_Homo sapiens_hsa007900.53675513
66Taste transduction_Homo sapiens_hsa047420.52565792
67ABC transporters_Homo sapiens_hsa020100.51684239
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51575754
69Autoimmune thyroid disease_Homo sapiens_hsa053200.49727342
70Ovarian steroidogenesis_Homo sapiens_hsa049130.49639810
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.46863266
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43194981
73Homologous recombination_Homo sapiens_hsa034400.42819370
74Lysine degradation_Homo sapiens_hsa003100.41987591
75Basal transcription factors_Homo sapiens_hsa030220.41839693
76Thyroid hormone synthesis_Homo sapiens_hsa049180.39874388
77Calcium signaling pathway_Homo sapiens_hsa040200.39526056
78Inositol phosphate metabolism_Homo sapiens_hsa005620.39153217
79Nicotine addiction_Homo sapiens_hsa050330.35960817
80Allograft rejection_Homo sapiens_hsa053300.35561545
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32323787
82Collecting duct acid secretion_Homo sapiens_hsa049660.32303276
83cAMP signaling pathway_Homo sapiens_hsa040240.31835695
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31117045
85Carbon metabolism_Homo sapiens_hsa012000.30178383
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.30002872
87Pertussis_Homo sapiens_hsa051330.29622222
88Arachidonic acid metabolism_Homo sapiens_hsa005900.28661962
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26145183
90Graft-versus-host disease_Homo sapiens_hsa053320.25083997
91RNA polymerase_Homo sapiens_hsa030200.24968382
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23762090
93Fatty acid elongation_Homo sapiens_hsa000620.22887795
94African trypanosomiasis_Homo sapiens_hsa051430.21711385
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20565586
96PPAR signaling pathway_Homo sapiens_hsa033200.19875762
97Tight junction_Homo sapiens_hsa045300.19683446
98Vitamin digestion and absorption_Homo sapiens_hsa049770.18882653
99Serotonergic synapse_Homo sapiens_hsa047260.18581087
100GABAergic synapse_Homo sapiens_hsa047270.18047744

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