ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cysteine metabolic process (GO:0006534)	7.77256437
2	leukotriene biosynthetic process (GO:0019370)	7.00026663
3	alanine transport (GO:0032328)	5.20042098
4	L-serine transport (GO:0015825)	4.64056956
5	proteasome assembly (GO:0043248)	4.59566804
6	glutathione metabolic process (GO:0006749)	4.42836865
7	fatty acid derivative biosynthetic process (GO:1901570)	4.33288303
8	icosanoid biosynthetic process (GO:0046456)	4.33288303
9	response to nitrosative stress (GO:0051409)	4.30386327
10	leukotriene metabolic process (GO:0006691)	4.19595994
11	serine family amino acid biosynthetic process (GO:0009070)	4.18515129
12	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	4.09432902
13	regulation of mitochondrial translation (GO:0070129)	4.04256228
14	C4-dicarboxylate transport (GO:0015740)	3.91676551
15	histone-serine phosphorylation (GO:0035404)	3.89560612
16	glutathione derivative metabolic process (GO:1901685)	3.83608325
17	glutathione derivative biosynthetic process (GO:1901687)	3.83608325
18	serine transport (GO:0032329)	3.71929743
19	mitotic metaphase plate congression (GO:0007080)	3.71121749
20	unsaturated fatty acid biosynthetic process (GO:0006636)	3.55568674
21	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.51238661
22	protein prenylation (GO:0018342)	3.46018407
23	prenylation (GO:0097354)	3.46018407
24	cellular response to zinc ion (GO:0071294)	3.45752860
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.41372545
26	NADH dehydrogenase complex assembly (GO:0010257)	3.41372545
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.41372545
28	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.41079505
29	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.36209249
30	CENP-A containing nucleosome assembly (GO:0034080)	3.35822590
31	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.34271923
32	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.34271923
33	protein complex biogenesis (GO:0070271)	3.29632624
34	ribosomal small subunit assembly (GO:0000028)	3.29096031
35	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.28202999
36	chromatin remodeling at centromere (GO:0031055)	3.27660598
37	rRNA methylation (GO:0031167)	3.25724508
38	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.25551421
39	peptide catabolic process (GO:0043171)	3.21534178
40	L-alpha-amino acid transmembrane transport (GO:1902475)	3.21254190
41	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.20938617
42	viral mRNA export from host cell nucleus (GO:0046784)	3.19404063
43	rRNA modification (GO:0000154)	3.18661227
44	nonribosomal peptide biosynthetic process (GO:0019184)	3.07149040
45	positive regulation of cAMP-mediated signaling (GO:0043950)	3.05869537
46	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.04331501
47	sulfur amino acid biosynthetic process (GO:0000097)	3.01885786
48	negative regulation of ligase activity (GO:0051352)	3.00963590
49	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.00963590
50	regulation of cellular amino acid metabolic process (GO:0006521)	2.99574362
51	mitochondrial respiratory chain complex assembly (GO:0033108)	2.98139823
52	respiratory chain complex IV assembly (GO:0008535)	2.96740167
53	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.96396082
54	L-phenylalanine metabolic process (GO:0006558)	2.96396082
55	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.94992633
56	metaphase plate congression (GO:0051310)	2.94241633
57	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.92848384
58	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.92848384
59	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.92848384
60	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.91543739
61	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.91543739
62	L-serine metabolic process (GO:0006563)	2.91453244
63	protein localization to kinetochore (GO:0034501)	2.86763878
64	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.82906986
65	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.82906986
66	spindle checkpoint (GO:0031577)	2.79985019
67	peptidyl-histidine modification (GO:0018202)	2.79248358
68	negative regulation of cAMP-mediated signaling (GO:0043951)	2.78531299
69	negative regulation of chromosome segregation (GO:0051985)	2.77113945
70	cytochrome complex assembly (GO:0017004)	2.76793959
71	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.76635947
72	negative regulation of sister chromatid segregation (GO:0033046)	2.76635947
73	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.76635947
74	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.76635947
75	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.76635947
76	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.75552514
77	histone exchange (GO:0043486)	2.75145802
78	lateral sprouting from an epithelium (GO:0060601)	2.73497086
79	heme transport (GO:0015886)	2.73434462
80	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.73360169
81	glucosamine-containing compound catabolic process (GO:1901072)	2.70727545
82	replication fork processing (GO:0031297)	2.68940725
83	DNA demethylation (GO:0080111)	2.68392169
84	pteridine-containing compound biosynthetic process (GO:0042559)	2.68045065
85	nucleotide transmembrane transport (GO:1901679)	2.67264800
86	protein targeting to mitochondrion (GO:0006626)	2.67122461
87	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.67041452
88	C21-steroid hormone biosynthetic process (GO:0006700)	2.65303167
89	basic amino acid transport (GO:0015802)	2.63723366
90	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.63140250
91	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.62841265
92	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.62841265
93	serine family amino acid metabolic process (GO:0009069)	2.62824984
94	positive regulation of ligase activity (GO:0051351)	2.61806449
95	DNA replication checkpoint (GO:0000076)	2.60626134
96	glutathione biosynthetic process (GO:0006750)	2.59542730
97	urogenital system development (GO:0001655)	2.59264311
98	termination of RNA polymerase III transcription (GO:0006386)	2.59135220
99	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.59135220
100	protein ADP-ribosylation (GO:0006471)	2.58243921

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	9.47534385
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.22314876
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.54613215
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.49910920
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.17610059
6	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.91647404
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.88108598
8	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.78987444
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.41254741
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.37526180
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.35485174
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.35177752
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.34143665
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.19276272
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.13570216
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12667056
17	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.09861480
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.07002442
19	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.03114934
20	E2F7_22180533_ChIP-Seq_HELA_Human	1.91252951
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.90783139
22	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.85920932
23	DCP1A_22483619_ChIP-Seq_HELA_Human	1.85165014
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.83310101
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.81034636
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74167425
27	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.61896660
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.61163038
29	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.59854806
30	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.59086108
31	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.57108099
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.56344106
33	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.53271650
34	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.53054011
35	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.50100159
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.46782954
37	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.41836443
38	VDR_22108803_ChIP-Seq_LS180_Human	1.37292562
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.34421088
40	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.32693724
41	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.29874355
42	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.28964193
43	AR_20517297_ChIP-Seq_VCAP_Human	1.27586275
44	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.24112358
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24108826
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.19671128
47	EGR1_19032775_ChIP-ChIP_M12_Human	1.19548020
48	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18900608
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.15955800
50	TTF2_22483619_ChIP-Seq_HELA_Human	1.14316405
51	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.13075596
52	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11069362
53	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.09919916
54	RBPJ_21746931_ChIP-Seq_IB4_Human	1.09410768
55	IRF1_19129219_ChIP-ChIP_H3396_Human	1.08656463
56	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.08287048
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04844960
58	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.04704051
59	EWS_26573619_Chip-Seq_HEK293_Human	1.04330996
60	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.01609248
61	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.00533066
62	XRN2_22483619_ChIP-Seq_HELA_Human	0.99456031
63	EOMES_21245162_ChIP-Seq_HESCs_Human	0.99296257
64	CBP_20019798_ChIP-Seq_JUKART_Human	0.98990094
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98990094
66	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.98679978
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98372893
68	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.96591141
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.95632686
70	TP53_16413492_ChIP-PET_HCT116_Human	0.94932794
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93751908
72	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.93523689
73	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.93470716
74	P300_19829295_ChIP-Seq_ESCs_Human	0.93432282
75	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.92447387
76	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89098319
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.87492520
78	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.85900533
79	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.85040188
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.84760598
81	NANOG_19829295_ChIP-Seq_ESCs_Human	0.84222612
82	SOX2_19829295_ChIP-Seq_ESCs_Human	0.84222612
83	GABP_19822575_ChIP-Seq_HepG2_Human	0.84020193
84	CDX2_22108803_ChIP-Seq_LS180_Human	0.83216244
85	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.83107588
86	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.82337316
87	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.82093751
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.81941314
89	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.80277651
90	ZNF274_21170338_ChIP-Seq_K562_Hela	0.78727085
91	ELF5_23300383_ChIP-Seq_T47D_Human	0.78044485
92	TP53_22573176_ChIP-Seq_HFKS_Human	0.77818185
93	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.77409407
94	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.76896897
95	ETV1_20927104_ChIP-Seq_GIST48_Human	0.76284801
96	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.75310141
97	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.74542331
98	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.74262135
99	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.73680828
100	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.73620920

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	3.70432069
2	MP0004019_abnormal_vitamin_homeostasis	3.63925162
3	MP0002163_abnormal_gland_morphology	2.95651303
4	MP0009697_abnormal_copulation	2.80683203
5	MP0005666_abnormal_adipose_tissue	2.72831826
6	MP0010352_gastrointestinal_tract_polyps	2.67297950
7	MP0003693_abnormal_embryo_hatching	2.63944468
8	MP0003950_abnormal_plasma_membrane	2.55101785
9	MP0003136_yellow_coat_color	2.53619641
10	MP0004185_abnormal_adipocyte_glucose	2.39755187
11	MP0005377_hearing/vestibular/ear_phenot	2.27334357
12	MP0003878_abnormal_ear_physiology	2.27334357
13	MP0008877_abnormal_DNA_methylation	2.16179977
14	MP0004957_abnormal_blastocyst_morpholog	2.13480236
15	MP0010094_abnormal_chromosome_stability	1.95934815
16	MP0008875_abnormal_xenobiotic_pharmacok	1.90748255
17	MP0003315_abnormal_perineum_morphology	1.85038366
18	MP0004233_abnormal_muscle_weight	1.82361061
19	MP0001756_abnormal_urination	1.80435890
20	MP0010386_abnormal_urinary_bladder	1.78305258
21	MP0005379_endocrine/exocrine_gland_phen	1.77689261
22	MP0005375_adipose_tissue_phenotype	1.77625405
23	MP0006035_abnormal_mitochondrial_morpho	1.72149976
24	MP0008872_abnormal_physiological_respon	1.68593367
25	MP0005171_absent_coat_pigmentation	1.67451330
26	MP0008058_abnormal_DNA_repair	1.67177825
27	MP0003186_abnormal_redox_activity	1.65122366
28	MP0005332_abnormal_amino_acid	1.59074406
29	MP0000372_irregular_coat_pigmentation	1.53090567
30	MP0003077_abnormal_cell_cycle	1.53065744
31	MP0000358_abnormal_cell_content/	1.51422702
32	MP0003941_abnormal_skin_development	1.50826638
33	MP0003111_abnormal_nucleus_morphology	1.49320575
34	MP0008057_abnormal_DNA_replication	1.48154280
35	MP0005083_abnormal_biliary_tract	1.46703769
36	MP0004147_increased_porphyrin_level	1.44863381
37	MP0005670_abnormal_white_adipose	1.35068118
38	MP0004215_abnormal_myocardial_fiber	1.34620178
39	MP0002938_white_spotting	1.31621333
40	MP0003011_delayed_dark_adaptation	1.29152070
41	MP0005085_abnormal_gallbladder_physiolo	1.28124312
42	MP0003718_maternal_effect	1.26845934
43	MP0006036_abnormal_mitochondrial_physio	1.22485474
44	MP0008932_abnormal_embryonic_tissue	1.20591184
45	MP0005623_abnormal_meninges_morphology	1.17937172
46	MP0000749_muscle_degeneration	1.16064121
47	MP0008789_abnormal_olfactory_epithelium	1.15892911
48	MP0002277_abnormal_respiratory_mucosa	1.14006040
49	MP0003252_abnormal_bile_duct	1.12208228
50	MP0005584_abnormal_enzyme/coenzyme_acti	1.11026118
51	MP0000537_abnormal_urethra_morphology	1.04834535
52	MP0002837_dystrophic_cardiac_calcinosis	1.03903223
53	MP0006072_abnormal_retinal_apoptosis	1.02930603
54	MP0000639_abnormal_adrenal_gland	1.02646865
55	MP0004142_abnormal_muscle_tone	1.00120195
56	MP0003890_abnormal_embryonic-extraembry	0.99305442
57	MP0003806_abnormal_nucleotide_metabolis	0.96762002
58	MP0005076_abnormal_cell_differentiation	0.95388046
59	MP0003786_premature_aging	0.94532782
60	MP0002653_abnormal_ependyma_morphology	0.92973178
61	MP0003195_calcinosis	0.92068174
62	MP0002089_abnormal_postnatal_growth/wei	0.91741704
63	MP0005394_taste/olfaction_phenotype	0.91406193
64	MP0005499_abnormal_olfactory_system	0.91406193
65	MP0002108_abnormal_muscle_morphology	0.91182883
66	MP0000538_abnormal_urinary_bladder	0.89688891
67	MP0000579_abnormal_nail_morphology	0.86037600
68	MP0002115_abnormal_skeleton_extremities	0.85179710
69	MP0005551_abnormal_eye_electrophysiolog	0.84300267
70	MP0003567_abnormal_fetal_cardiomyocyte	0.83947684
71	MP0000163_abnormal_cartilage_morphology	0.83117488
72	MP0002796_impaired_skin_barrier	0.82345416
73	MP0001764_abnormal_homeostasis	0.81236934
74	MP0001119_abnormal_female_reproductive	0.79582308
75	MP0000733_abnormal_muscle_development	0.79298519
76	MP0005501_abnormal_skin_physiology	0.76729527
77	MP0002111_abnormal_tail_morphology	0.76344287
78	MP0001293_anophthalmia	0.75340796
79	MP0003936_abnormal_reproductive_system	0.74607331
80	MP0009250_abnormal_appendicular_skeleto	0.73731144
81	MP0001963_abnormal_hearing_physiology	0.72642406
82	MP0006292_abnormal_olfactory_placode	0.71895030
83	MP0002102_abnormal_ear_morphology	0.71779694
84	MP0002751_abnormal_autonomic_nervous	0.71007232
85	MP0004084_abnormal_cardiac_muscle	0.70329027
86	MP0001145_abnormal_male_reproductive	0.69760106
87	MP0001984_abnormal_olfaction	0.68093233
88	MP0005253_abnormal_eye_physiology	0.67573907
89	MP0001529_abnormal_vocalization	0.67528956
90	MP0003566_abnormal_cell_adhesion	0.66651410
91	MP0000534_abnormal_ureter_morphology	0.65777081
92	MP0002210_abnormal_sex_determination	0.65619473
93	MP0002736_abnormal_nociception_after	0.65139715
94	MP0008004_abnormal_stomach_pH	0.64822010
95	MP0000653_abnormal_sex_gland	0.63760731
96	MP0005508_abnormal_skeleton_morphology	0.62474974
97	MP0005187_abnormal_penis_morphology	0.61410640
98	MP0005620_abnormal_muscle_contractility	0.60562768
99	MP0002160_abnormal_reproductive_system	0.60398560
100	MP0005275_abnormal_skin_tensile	0.56911441

Predicted human phenotypes

Rank	Gene Set	Z-score
1	J-shaped sella turcica (HP:0002680)	4.61378288
2	Carpal bone hypoplasia (HP:0001498)	3.80942319
3	Abnormality of glycolipid metabolism (HP:0010969)	3.69616219
4	Abnormality of liposaccharide metabolism (HP:0010968)	3.69616219
5	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.69616219
6	Vertebral arch anomaly (HP:0008438)	3.52941709
7	Birth length less than 3rd percentile (HP:0003561)	3.49508073
8	Nemaline bodies (HP:0003798)	3.46740188
9	Beaking of vertebral bodies (HP:0004568)	3.31602969
10	Hypoplastic pelvis (HP:0008839)	3.28222432
11	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.26970451
12	Nonprogressive disorder (HP:0003680)	3.17371342
13	Abnormality of the sella turcica (HP:0002679)	3.17300743
14	Muscle fiber inclusion bodies (HP:0100299)	3.16713462
15	Aortic regurgitation (HP:0001659)	3.02696934
16	Diastasis recti (HP:0001540)	3.02580558
17	Conjugated hyperbilirubinemia (HP:0002908)	2.95110008
18	Central scotoma (HP:0000603)	2.88238965
19	Acute necrotizing encephalopathy (HP:0006965)	2.87400610
20	Facial diplegia (HP:0001349)	2.87333503
21	Colon cancer (HP:0003003)	2.82760060
22	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.80097156
23	Mitochondrial inheritance (HP:0001427)	2.78978108
24	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.77142104
25	Hypoplasia of the fovea (HP:0007750)	2.77142104
26	Abnormality of the lumbar spine (HP:0100712)	2.76409963
27	Rib fusion (HP:0000902)	2.74558498
28	Broad alveolar ridges (HP:0000187)	2.73947876
29	Increased CSF lactate (HP:0002490)	2.73938481
30	Deformed sella turcica (HP:0002681)	2.73014507
31	Abnormality of placental membranes (HP:0011409)	2.69977439
32	Amniotic constriction ring (HP:0009775)	2.69977439
33	Abnormal mitochondria in muscle tissue (HP:0008316)	2.65666514
34	Acute encephalopathy (HP:0006846)	2.58804765
35	Intestinal atresia (HP:0011100)	2.57698101
36	Hypoplastic scapulae (HP:0000882)	2.55855904
37	Aplasia/Hypoplasia of the scapulae (HP:0006713)	2.55855904
38	Hepatocellular necrosis (HP:0001404)	2.50460183
39	Abnormality of the fovea (HP:0000493)	2.42343193
40	Increased hepatocellular lipid droplets (HP:0006565)	2.38864042
41	Broad ribs (HP:0000885)	2.37661306
42	Abnormality of the labia minora (HP:0012880)	2.36030009
43	Progressive muscle weakness (HP:0003323)	2.35137882
44	Hypoplastic labia majora (HP:0000059)	2.34754159
45	Abnormality of the labia majora (HP:0012881)	2.34229891
46	Flat acetabular roof (HP:0003180)	2.26708686
47	Large for gestational age (HP:0001520)	2.25468067
48	Type I transferrin isoform profile (HP:0003642)	2.22579661
49	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.20615413
50	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.20615413
51	Progressive macrocephaly (HP:0004481)	2.18788622
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.17105789
53	Abnormality of the labia (HP:0000058)	2.17069431
54	Thoracic kyphosis (HP:0002942)	2.15878558
55	Adrenal hypoplasia (HP:0000835)	2.15590661
56	Exercise intolerance (HP:0003546)	2.15469392
57	Lipid accumulation in hepatocytes (HP:0006561)	2.13788885
58	Cerebral edema (HP:0002181)	2.12986709
59	Thickened calvaria (HP:0002684)	2.12919978
60	Hepatic necrosis (HP:0002605)	2.12910324
61	Protuberant abdomen (HP:0001538)	2.11934194
62	Exercise-induced muscle cramps (HP:0003710)	2.10932278
63	Abnormality of macular pigmentation (HP:0008002)	2.10847769
64	Abnormality of pyrimidine metabolism (HP:0004353)	2.09623299
65	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.09053027
66	Abnormality of alanine metabolism (HP:0010916)	2.09053027
67	Hyperalaninemia (HP:0003348)	2.09053027
68	Paralysis (HP:0003470)	2.08547358
69	Microvesicular hepatic steatosis (HP:0001414)	2.08127570
70	Rhabdomyosarcoma (HP:0002859)	2.06839419
71	True hermaphroditism (HP:0010459)	2.05467961
72	Spastic paraparesis (HP:0002313)	2.05467453
73	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.04231622
74	Hypoplastic female external genitalia (HP:0012815)	2.03199806
75	Abnormal number of erythroid precursors (HP:0012131)	2.02428134
76	Anomalous pulmonary venous return (HP:0010772)	2.00364940
77	Labial hypoplasia (HP:0000066)	1.98542910
78	Thoracolumbar scoliosis (HP:0002944)	1.96804412
79	Corneal dystrophy (HP:0001131)	1.96702343
80	Scotoma (HP:0000575)	1.93435612
81	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92896164
82	Ependymoma (HP:0002888)	1.92215430
83	Megaloblastic anemia (HP:0001889)	1.91477633
84	Partial agenesis of the corpus callosum (HP:0001338)	1.89864068
85	Homocystinuria (HP:0002156)	1.88310654
86	Abnormality of homocysteine metabolism (HP:0010919)	1.88310654
87	Astrocytoma (HP:0009592)	1.85940932
88	Abnormality of the astrocytes (HP:0100707)	1.85940932
89	Slow saccadic eye movements (HP:0000514)	1.85662917
90	Pancreatic fibrosis (HP:0100732)	1.84391928
91	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.80376006
92	Hypoplasia of the odontoid process (HP:0003311)	1.80292980
93	Flared iliac wings (HP:0002869)	1.77321956
94	Anencephaly (HP:0002323)	1.76400787
95	Abnormality of serum amino acid levels (HP:0003112)	1.76364279
96	Increased serum lactate (HP:0002151)	1.76195249
97	Respiratory failure (HP:0002878)	1.74224593
98	Duplicated collecting system (HP:0000081)	1.74136371
99	Abnormality of the pulmonary veins (HP:0011718)	1.72513075
100	Lethargy (HP:0001254)	1.72496004

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	4.56015735
2	PBK	3.64120864
3	EPHA2	3.59183217
4	BUB1	3.31925096
5	MAP4K2	2.70685861
6	WNK4	2.52752697
7	FRK	2.48261739
8	OBSCN	2.46009671
9	TSSK6	2.39901915
10	TNIK	2.32576189
11	RPS6KA4	2.26690143
12	TTK	2.23855356
13	CAMKK2	2.23320379
14	TIE1	2.17215135
15	DYRK3	2.14965848
16	BRSK2	2.13798578
17	PDK2	2.11786648
18	NME1	1.93541655
19	BCKDK	1.80763025
20	MAP3K7	1.74708800
21	VRK2	1.73687140
22	CAMK4	1.73221686
23	ZAK	1.52127258
24	YES1	1.41393955
25	EPHA3	1.35085517
26	ACVR1B	1.31028222
27	NEK1	1.30023027
28	TAF1	1.29703686
29	RIPK4	1.27843885
30	RPS6KB2	1.22075770
31	NME2	1.20705186
32	NLK	1.18496980
33	CSNK1G1	1.15608451
34	CAMK1	1.14813641
35	VRK1	1.09367616
36	MKNK2	1.06287490
37	MELK	1.00806710
38	BMPR1B	0.95621895
39	MAP3K3	0.94482058
40	PLK3	0.94060502
41	DYRK2	0.92798493
42	FLT3	0.92455485
43	BRSK1	0.89194269
44	PINK1	0.86861775
45	PLK1	0.85827250
46	CAMK2D	0.85649749
47	CLK1	0.81876245
48	CAMK2G	0.81113201
49	MKNK1	0.77560699
50	WNK1	0.77245871
51	CDC7	0.76373838
52	WNK3	0.76130735
53	FER	0.75568183
54	SRPK1	0.73922643
55	STK24	0.73428271
56	PIM2	0.72791009
57	STK38L	0.72259385
58	RPS6KA5	0.72230090
59	CSNK1A1L	0.71538686
60	PHKG2	0.70624417
61	PHKG1	0.70624417
62	MST1R	0.70058764
63	MET	0.69725568
64	AURKB	0.67083735
65	STK4	0.66359281
66	SGK223	0.65443632
67	SGK494	0.65443632
68	GRK1	0.63035996
69	FGFR1	0.61763604
70	SGK2	0.59251956
71	ABL2	0.58419582
72	PTK2B	0.56818944
73	HIPK2	0.55248928
74	MAP2K3	0.54539859
75	CAMK2B	0.54326678
76	CSNK1G2	0.53412122
77	PIM1	0.53282775
78	STK39	0.53097218
79	ADRBK2	0.51979795
80	AKT2	0.51376944
81	MYLK	0.48371801
82	ADRBK1	0.48233989
83	RPS6KA6	0.47441861
84	MAP3K2	0.46667633
85	STK16	0.46328803
86	CHEK2	0.46290738
87	MAP3K8	0.43340111
88	CAMK2A	0.42994141
89	ATR	0.39949082
90	NUAK1	0.39673316
91	INSRR	0.39093580
92	CAMK1D	0.37954264
93	TLK1	0.37500139
94	ATM	0.34423519
95	CSNK1G3	0.34085100
96	OXSR1	0.30478633
97	GSK3A	0.29120808
98	RPS6KC1	0.26722001
99	RPS6KL1	0.26722001
100	PRKG1	0.26415904

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.15580134
2	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.54476311
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.09129696
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.70296944
5	Mismatch repair_Homo sapiens_hsa03430	2.52526609
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.41616783
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.35489409
8	Fatty acid elongation_Homo sapiens_hsa00062	2.33024725
9	RNA polymerase_Homo sapiens_hsa03020	2.24734754
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.21791102
11	Ribosome_Homo sapiens_hsa03010	2.16166276
12	Glutathione metabolism_Homo sapiens_hsa00480	2.00195840
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.98959554
14	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.92211198
15	Parkinsons disease_Homo sapiens_hsa05012	1.83836526
16	DNA replication_Homo sapiens_hsa03030	1.82585436
17	Pyruvate metabolism_Homo sapiens_hsa00620	1.65860125
18	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.63296625
19	Huntingtons disease_Homo sapiens_hsa05016	1.61205317
20	Basal transcription factors_Homo sapiens_hsa03022	1.61183502
21	One carbon pool by folate_Homo sapiens_hsa00670	1.57879702
22	Alzheimers disease_Homo sapiens_hsa05010	1.54133996
23	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.49274605
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.47009137
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.42884575
26	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.40259903
27	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.39958608
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.34886474
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.34836469
30	Homologous recombination_Homo sapiens_hsa03440	1.30440500
31	Circadian rhythm_Homo sapiens_hsa04710	1.21936607
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.18859666
33	Oocyte meiosis_Homo sapiens_hsa04114	1.16861471
34	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.15835159
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14343256
36	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.14067116
37	Carbon metabolism_Homo sapiens_hsa01200	1.13272551
38	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.11726236
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.10841506
40	Sulfur relay system_Homo sapiens_hsa04122	1.08090288
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.07731324
42	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07301350
43	Nucleotide excision repair_Homo sapiens_hsa03420	1.07113805
44	RNA degradation_Homo sapiens_hsa03018	1.05955193
45	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.04264066
46	Purine metabolism_Homo sapiens_hsa00230	1.04179238
47	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02791923
48	RNA transport_Homo sapiens_hsa03013	0.98080968
49	Cell cycle_Homo sapiens_hsa04110	0.97028822
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.96738677
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.91494770
52	Base excision repair_Homo sapiens_hsa03410	0.89518114
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88140790
54	Propanoate metabolism_Homo sapiens_hsa00640	0.87810159
55	Tyrosine metabolism_Homo sapiens_hsa00350	0.87662441
56	Phototransduction_Homo sapiens_hsa04744	0.86512354
57	Folate biosynthesis_Homo sapiens_hsa00790	0.84646430
58	Glucagon signaling pathway_Homo sapiens_hsa04922	0.81192191
59	Butanoate metabolism_Homo sapiens_hsa00650	0.78841962
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77820806
61	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.77425600
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77273127
63	ABC transporters_Homo sapiens_hsa02010	0.75473380
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74830649
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73935469
66	Fatty acid degradation_Homo sapiens_hsa00071	0.72513630
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69712329
68	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.68623264
69	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.68271382
70	Metabolic pathways_Homo sapiens_hsa01100	0.67933418
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.67330407
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67293344
73	Amphetamine addiction_Homo sapiens_hsa05031	0.64436645
74	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.64290056
75	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.63130680
76	Galactose metabolism_Homo sapiens_hsa00052	0.62326306
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60378870
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58993181
79	Renin secretion_Homo sapiens_hsa04924	0.57479021
80	Phenylalanine metabolism_Homo sapiens_hsa00360	0.54461095
81	Wnt signaling pathway_Homo sapiens_hsa04310	0.50730149
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50407790
83	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.50261822
84	Peroxisome_Homo sapiens_hsa04146	0.46336107
85	Spliceosome_Homo sapiens_hsa03040	0.42016608
86	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.40913169
87	Mineral absorption_Homo sapiens_hsa04978	0.38841456
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.38604933
89	Arginine biosynthesis_Homo sapiens_hsa00220	0.36128301
90	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.34861850
91	Tryptophan metabolism_Homo sapiens_hsa00380	0.34094078
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.32978286
93	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.32557164
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.32362144
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.32311580
96	Retinol metabolism_Homo sapiens_hsa00830	0.32187939
97	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.32140234
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.31748950
99	Taste transduction_Homo sapiens_hsa04742	0.30247255
100	Complement and coagulation cascades_Homo sapiens_hsa04610	0.29683739

KRT18P62

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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