KRT18P63

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1production of molecular mediator involved in inflammatory response (GO:0002532)9.26440881
2attachment of spindle microtubules to kinetochore (GO:0008608)8.95032640
3regulation of sarcomere organization (GO:0060297)8.14276839
4negative regulation of translation, ncRNA-mediated (GO:0040033)8.05131129
5regulation of translation, ncRNA-mediated (GO:0045974)8.05131129
6negative regulation of translation involved in gene silencing by miRNA (GO:0035278)8.05131129
7negative regulation of nitric-oxide synthase activity (GO:0051001)6.56512963
8mitotic metaphase plate congression (GO:0007080)6.51818122
9activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO6.37851861
10nuclear pore organization (GO:0006999)6.37600851
11membrane raft organization (GO:0031579)5.98615662
12regulation of skeletal muscle contraction (GO:0014819)5.77053524
13plasma membrane repair (GO:0001778)5.74604676
14microtubule cytoskeleton organization involved in mitosis (GO:1902850)5.70279019
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.60943334
16negative regulation of protein localization to cell surface (GO:2000009)5.56643474
17negative regulation of muscle hypertrophy (GO:0014741)5.55580398
18ribonucleoprotein complex disassembly (GO:0032988)5.52827356
19heart contraction (GO:0060047)5.23327718
20heart process (GO:0003015)5.23327718
21skeletal muscle tissue regeneration (GO:0043403)5.09985337
22metaphase plate congression (GO:0051310)5.09275136
23motile cilium assembly (GO:0044458)4.93758422
24negative regulation of potassium ion transmembrane transport (GO:1901380)4.76516376
25organelle disassembly (GO:1903008)4.68656450
26negative regulation of organelle assembly (GO:1902116)4.61384254
27regulation of action potential (GO:0098900)4.34225538
28regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.28666013
29positive regulation of myotube differentiation (GO:0010831)4.28436425
30microtubule anchoring (GO:0034453)4.26789558
31regulation of hippo signaling (GO:0035330)4.25369462
32negative regulation of heart growth (GO:0061117)4.23626918
33negative regulation of cardiac muscle tissue growth (GO:0055022)4.23626918
34entrainment of circadian clock by photoperiod (GO:0043153)4.21500129
35positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.20141665
36negative regulation of monooxygenase activity (GO:0032769)4.17957920
37striated muscle atrophy (GO:0014891)4.16428873
38negative regulation of cardiac muscle hypertrophy (GO:0010614)4.15837900
39pericardium development (GO:0060039)3.94392448
40negative regulation of cell size (GO:0045792)3.87680749
41cardiac myofibril assembly (GO:0055003)3.83006835
42positive regulation of microtubule polymerization (GO:0031116)3.81192949
43intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)3.78492643
44muscle atrophy (GO:0014889)3.78161682
45epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.70925524
46myoblast fusion (GO:0007520)3.58483418
47membrane assembly (GO:0071709)3.54762979
48regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.51361457
49photoperiodism (GO:0009648)3.49401822
50entrainment of circadian clock (GO:0009649)3.48181300
51skeletal muscle fiber development (GO:0048741)3.46806173
52establishment of chromosome localization (GO:0051303)3.46106092
53nerve growth factor signaling pathway (GO:0038180)3.43572689
54regulation of alkaline phosphatase activity (GO:0010692)3.36066844
55protein neddylation (GO:0045116)3.33489274
56regulation of p38MAPK cascade (GO:1900744)3.31925354
57imidazole-containing compound metabolic process (GO:0052803)3.30993577
58acrosome reaction (GO:0007340)3.23901207
59spermatid nucleus differentiation (GO:0007289)3.22755238
60postreplication repair (GO:0006301)3.18491298
61myotube cell development (GO:0014904)3.17227865
62termination of RNA polymerase III transcription (GO:0006386)3.17182330
63transcription elongation from RNA polymerase III promoter (GO:0006385)3.17182330
64positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.16182249
65DNA integration (GO:0015074)3.15090922
66centriole assembly (GO:0098534)3.13372031
67regulation of sister chromatid cohesion (GO:0007063)3.12454512
68regulation of transforming growth factor beta2 production (GO:0032909)3.05360725
69syncytium formation by plasma membrane fusion (GO:0000768)3.05073245
70microtubule depolymerization (GO:0007019)3.04405464
71primary alcohol catabolic process (GO:0034310)3.04343919
72folic acid-containing compound biosynthetic process (GO:0009396)3.03805195
73cerebral cortex radially oriented cell migration (GO:0021799)3.02570610
74DNA deamination (GO:0045006)3.01472947
75protein peptidyl-prolyl isomerization (GO:0000413)3.01057527
76negative regulation of cardiac muscle tissue development (GO:0055026)2.95836411
77regulation of protein localization to cell surface (GO:2000008)2.95401804
78glial cell proliferation (GO:0014009)2.92348212
79histone mRNA catabolic process (GO:0071044)2.87605973
80positive regulation of skeletal muscle tissue development (GO:0048643)2.85446129
81RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77594335
82regulation of translation in response to stress (GO:0043555)2.75836072
83DNA catabolic process, exonucleolytic (GO:0000738)2.74366587
84cardiac muscle cell development (GO:0055013)2.74069394
85lens fiber cell differentiation (GO:0070306)2.73316257
86regulation of cardiac muscle cell differentiation (GO:2000725)2.70696004
87DNA demethylation (GO:0080111)2.68935002
88histone H3-K9 methylation (GO:0051567)2.67032791
89regulation of muscle adaptation (GO:0043502)2.65943984
90proteasome assembly (GO:0043248)2.65460961
91RNA destabilization (GO:0050779)2.65212450
92syncytium formation (GO:0006949)2.62510946
93single strand break repair (GO:0000012)2.58833000
94inositol phosphate-mediated signaling (GO:0048016)2.57440278
95myofibril assembly (GO:0030239)2.57213111
96glucosamine-containing compound catabolic process (GO:1901072)2.56217416
97embryonic foregut morphogenesis (GO:0048617)2.54694813
98replicative senescence (GO:0090399)2.52363790
99negative regulation of osteoblast proliferation (GO:0033689)2.51753094
100response to inactivity (GO:0014854)2.50790201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.46116186
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.76180143
3ZNF274_21170338_ChIP-Seq_K562_Hela3.24783305
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.19977548
5IGF1R_20145208_ChIP-Seq_DFB_Human3.12805230
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00260496
7GATA1_22025678_ChIP-Seq_K562_Human2.71228950
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.67037385
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52465068
10ELK1_19687146_ChIP-ChIP_HELA_Human2.48147751
11TAF15_26573619_Chip-Seq_HEK293_Human2.46310463
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.36253992
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.23702328
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13200864
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11762852
16SMAD_19615063_ChIP-ChIP_OVARY_Human1.99490918
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87411592
18FOXM1_23109430_ChIP-Seq_U2OS_Human1.84935244
19ELF5_23300383_ChIP-Seq_T47D_Human1.80939808
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80077072
21AUTS2_25519132_ChIP-Seq_293T-REX_Human1.77676322
22TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74698777
23POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74698777
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74471599
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73924657
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70396954
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68301522
28FUS_26573619_Chip-Seq_HEK293_Human1.65740443
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61993203
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57125719
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55032718
32FOXP3_21729870_ChIP-Seq_TREG_Human1.54978284
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.54380598
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52991892
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51502946
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50151313
37KLF5_20875108_ChIP-Seq_MESCs_Mouse1.50149522
38PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.49037283
39EWS_26573619_Chip-Seq_HEK293_Human1.48689232
40TP53_18474530_ChIP-ChIP_U2OS_Human1.48326867
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46592564
42VDR_23849224_ChIP-Seq_CD4+_Human1.43448784
43CBP_20019798_ChIP-Seq_JUKART_Human1.42806117
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42806117
45ER_23166858_ChIP-Seq_MCF-7_Human1.42425601
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39264952
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34661297
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33332286
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32846035
50TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.32796979
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32042584
52MYC_18940864_ChIP-ChIP_HL60_Human1.30504875
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29272372
54ETV1_20927104_ChIP-Seq_GIST48_Human1.27019424
55SMAD4_21799915_ChIP-Seq_A2780_Human1.26128233
56SOX9_26525672_Chip-Seq_HEART_Mouse1.25986713
57ERG_20517297_ChIP-Seq_VCAP_Human1.24712781
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.24171577
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23711671
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22931930
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22401582
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.22286729
63RUNX_20019798_ChIP-Seq_JUKART_Human1.21857389
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20825510
65MYC_19829295_ChIP-Seq_ESCs_Human1.20817293
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20326415
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.19969940
68NCOR_22424771_ChIP-Seq_293T_Human1.19933023
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.16602996
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16485917
71RBPJ_21746931_ChIP-Seq_IB4_Human1.16108046
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.15984039
73P300_19829295_ChIP-Seq_ESCs_Human1.14744948
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.14475918
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.13451290
76GBX2_23144817_ChIP-Seq_PC3_Human1.11525322
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10140032
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09208216
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07926700
80BRD4_25478319_ChIP-Seq_HGPS_Human1.05269888
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04711314
82AR_25329375_ChIP-Seq_VCAP_Human1.04422541
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.03726981
84WDR5_24793694_ChIP-Seq_LNCAP_Human1.03211235
85CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03007046
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02320127
87GATA3_26560356_Chip-Seq_TH2_Human1.01735270
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01589449
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98391819
90GATA6_21074721_ChIP-Seq_CACO-2_Human0.97591257
91PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97243707
92HNFA_21074721_ChIP-Seq_CACO-2_Human0.96766316
93TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.96640991
94P53_22387025_ChIP-Seq_ESCs_Mouse0.96253813
95NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96123476
96CJUN_26792858_Chip-Seq_BT549_Human0.95645565
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95382820
98NFYB_21822215_ChIP-Seq_K562_Human0.94764428
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94160352
100TCF4_18268006_ChIP-ChIP_LS174T_Human0.92962773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane7.93801194
2MP0008789_abnormal_olfactory_epithelium5.30409323
3MP0001529_abnormal_vocalization4.06491720
4MP0003828_pulmonary_edema4.00336421
5MP0000749_muscle_degeneration3.66135954
6MP0005394_taste/olfaction_phenotype3.65757000
7MP0005499_abnormal_olfactory_system3.65757000
8MP0004084_abnormal_cardiac_muscle3.41033856
9MP0001849_ear_inflammation2.88649679
10MP0002102_abnormal_ear_morphology2.51803810
11MP0000751_myopathy2.44850912
12MP0005410_abnormal_fertilization2.39994264
13MP0006292_abnormal_olfactory_placode2.29771260
14MP0006054_spinal_hemorrhage2.13966175
15MP0001293_anophthalmia2.03237439
16MP0004036_abnormal_muscle_relaxation1.99401782
17MP0004145_abnormal_muscle_electrophysio1.95123504
18MP0002163_abnormal_gland_morphology1.76425238
19MP0010030_abnormal_orbit_morphology1.73350166
20MP0008057_abnormal_DNA_replication1.71082158
21MP0002234_abnormal_pharynx_morphology1.66966327
22MP0000049_abnormal_middle_ear1.58391429
23MP0003763_abnormal_thymus_physiology1.56223532
24MP0004883_abnormal_blood_vessel1.55205658
25MP0004270_analgesia1.48906173
26MP0005253_abnormal_eye_physiology1.40496478
27MP0001485_abnormal_pinna_reflex1.39405946
28MP0005377_hearing/vestibular/ear_phenot1.34157363
29MP0003878_abnormal_ear_physiology1.34157363
30MP0003806_abnormal_nucleotide_metabolis1.33848572
31MP0000569_abnormal_digit_pigmentation1.33713430
32MP0008058_abnormal_DNA_repair1.33108619
33MP0004087_abnormal_muscle_fiber1.28849172
34MP0003077_abnormal_cell_cycle1.27716742
35MP0004782_abnormal_surfactant_physiolog1.25152021
36MP0000733_abnormal_muscle_development1.21633383
37MP0000759_abnormal_skeletal_muscle1.19576522
38MP0005379_endocrine/exocrine_gland_phen1.19544242
39MP0010094_abnormal_chromosome_stability1.17741874
40MP0010630_abnormal_cardiac_muscle1.12316935
41MP0005391_vision/eye_phenotype1.12228522
42MP0005623_abnormal_meninges_morphology1.09868246
43MP0003718_maternal_effect1.08196144
44MP0001764_abnormal_homeostasis1.04135288
45MP0003252_abnormal_bile_duct1.00313690
46MP0002233_abnormal_nose_morphology1.00309751
47MP0002269_muscular_atrophy0.98905958
48MP0000427_abnormal_hair_cycle0.98406295
49MP0002972_abnormal_cardiac_muscle0.98242933
50MP0002933_joint_inflammation0.98156350
51MP0002009_preneoplasia0.96850276
52MP0000647_abnormal_sebaceous_gland0.96423655
53MP0006072_abnormal_retinal_apoptosis0.95775823
54MP0008877_abnormal_DNA_methylation0.94979441
55MP0001929_abnormal_gametogenesis0.94273910
56MP0003698_abnormal_male_reproductive0.93656279
57MP0000467_abnormal_esophagus_morphology0.93317224
58MP0000750_abnormal_muscle_regeneration0.91665119
59MP0002751_abnormal_autonomic_nervous0.90824732
60MP0002736_abnormal_nociception_after0.88380494
61MP0002106_abnormal_muscle_physiology0.88228871
62MP0005620_abnormal_muscle_contractility0.85825958
63MP0002092_abnormal_eye_morphology0.84612410
64MP0001299_abnormal_eye_distance/0.83389900
65MP0003879_abnormal_hair_cell0.79255556
66MP0000678_abnormal_parathyroid_gland0.78669933
67MP0005187_abnormal_penis_morphology0.77364667
68MP0003221_abnormal_cardiomyocyte_apopto0.77274671
69MP0004742_abnormal_vestibular_system0.77114743
70MP0002210_abnormal_sex_determination0.76186540
71MP0005167_abnormal_blood-brain_barrier0.73068531
72MP0003787_abnormal_imprinting0.71987318
73MP0003786_premature_aging0.67630281
74MP0000372_irregular_coat_pigmentation0.66638018
75MP0001270_distended_abdomen0.66549857
76MP0001919_abnormal_reproductive_system0.66346654
77MP0003693_abnormal_embryo_hatching0.62864178
78MP0006276_abnormal_autonomic_nervous0.62452810
79MP0000631_abnormal_neuroendocrine_gland0.60989712
80MP0002697_abnormal_eye_size0.60507035
81MP0004215_abnormal_myocardial_fiber0.60465683
82MP0000747_muscle_weakness0.59365593
83MP0000490_abnormal_crypts_of0.57902105
84MP0001666_abnormal_nutrient_absorption0.56812562
85MP0002133_abnormal_respiratory_system0.56719846
86MP0005388_respiratory_system_phenotype0.56719846
87MP0010368_abnormal_lymphatic_system0.56476401
88MP0000653_abnormal_sex_gland0.55425570
89MP0003385_abnormal_body_wall0.53970457
90MP0008872_abnormal_physiological_respon0.53636276
91MP0005389_reproductive_system_phenotype0.53540743
92MP0002161_abnormal_fertility/fecundity0.52998088
93MP0001286_abnormal_eye_development0.52556440
94MP0001784_abnormal_fluid_regulation0.52341187
95MP0002095_abnormal_skin_pigmentation0.51820805
96MP0001544_abnormal_cardiovascular_syste0.51441267
97MP0005385_cardiovascular_system_phenoty0.51441267
98MP0003115_abnormal_respiratory_system0.49481261
99MP0004197_abnormal_fetal_growth/weight/0.49166662
100MP0001853_heart_inflammation0.49159309

Predicted human phenotypes

RankGene SetZ-score
1Calf muscle hypertrophy (HP:0008981)7.65389193
2Asymmetric septal hypertrophy (HP:0001670)7.12046475
3Muscle hypertrophy of the lower extremities (HP:0008968)6.72038050
4Type 2 muscle fiber atrophy (HP:0003554)5.59860977
5Exercise-induced muscle cramps (HP:0003710)5.33236275
6Hypoplasia of the thymus (HP:0000778)5.13303192
7Renal cortical cysts (HP:0000803)5.05036132
8Exercise-induced myalgia (HP:0003738)5.02856192
9Subaortic stenosis (HP:0001682)4.76423632
10Abnormality of the left ventricular outflow tract (HP:0011103)4.76423632
11Muscle fiber atrophy (HP:0100295)4.75073426
12Spondylolisthesis (HP:0003302)4.31191725
13Abnormality of the renal cortex (HP:0011035)3.56389344
14Small epiphyses (HP:0010585)3.47140957
15Chronic hepatic failure (HP:0100626)3.34713772
16Posterior subcapsular cataract (HP:0007787)3.29368373
17Abnormality of the calf musculature (HP:0001430)3.23310509
18Popliteal pterygium (HP:0009756)3.20146941
19Carpal bone hypoplasia (HP:0001498)3.20115873
20Myotonia (HP:0002486)3.16426803
21Gowers sign (HP:0003391)3.14448741
22Brushfield spots (HP:0001088)3.10700151
23IgM deficiency (HP:0002850)3.00283691
24Fatigable weakness (HP:0003473)2.98255669
25Abnormality of the neuromuscular junction (HP:0003398)2.98255669
26Hypoplastic pelvis (HP:0008839)2.84736740
27Muscle stiffness (HP:0003552)2.78553054
28Tubulointerstitial nephritis (HP:0001970)2.74387099
29Dry hair (HP:0011359)2.66322606
30Sudden death (HP:0001699)2.65969747
31Keratoconus (HP:0000563)2.56899186
32Increased corneal curvature (HP:0100692)2.56899186
33Palpebral edema (HP:0100540)2.52085632
34Arterial tortuosity (HP:0005116)2.51819363
35Bony spicule pigmentary retinopathy (HP:0007737)2.51338559
36Aortic aneurysm (HP:0004942)2.48487819
37Abnormal gallbladder physiology (HP:0012438)2.45496673
38Cholecystitis (HP:0001082)2.45496673
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42291579
40Prolonged QT interval (HP:0001657)2.41908245
41Eosinophilia (HP:0001880)2.35399372
42Neck muscle weakness (HP:0000467)2.31005713
43Amniotic constriction ring (HP:0009775)2.29258665
44Abnormality of placental membranes (HP:0011409)2.29258665
45Anhidrosis (HP:0000970)2.28570157
46Abnormal rod and cone electroretinograms (HP:0008323)2.24588976
47Attenuation of retinal blood vessels (HP:0007843)2.23772001
48Vascular tortuosity (HP:0004948)2.22072423
49B lymphocytopenia (HP:0010976)2.20618682
50Poor suck (HP:0002033)2.20252135
51Abnormality of the proximal phalanges of the hand (HP:0009834)2.18587583
52Supernumerary spleens (HP:0009799)2.17368213
53Abnormality of B cell number (HP:0010975)2.17193827
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.13243091
55Congenital sensorineural hearing impairment (HP:0008527)2.13127488
56Weak cry (HP:0001612)2.12418283
57Left ventricular hypertrophy (HP:0001712)2.11683554
58Nonprogressive disorder (HP:0003680)2.09881501
59Tubulointerstitial abnormality (HP:0001969)2.09467459
60T lymphocytopenia (HP:0005403)2.08105101
61Aortic dissection (HP:0002647)2.07284478
62Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01939827
63Abnormality of eosinophils (HP:0001879)1.99491366
64Abnormal biliary tract morphology (HP:0012440)1.99449752
65Depressed nasal tip (HP:0000437)1.99143982
66Clitoromegaly (HP:0000057)1.95761725
67Abnormality of T cell number (HP:0011839)1.95265707
68Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.90185677
69Papilledema (HP:0001085)1.89017186
70Flattened epiphyses (HP:0003071)1.84811819
71Aortic regurgitation (HP:0001659)1.83419314
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80825386
73Abnormality of alanine metabolism (HP:0010916)1.80825386
74Hyperalaninemia (HP:0003348)1.80825386
75Microvesicular hepatic steatosis (HP:0001414)1.78500597
76Increased serum pyruvate (HP:0003542)1.75969808
77Ventricular arrhythmia (HP:0004308)1.75319269
78Chorioretinal atrophy (HP:0000533)1.73916783
79Premature graying of hair (HP:0002216)1.73688633
80Granulocytopenia (HP:0001913)1.71278746
81Central scotoma (HP:0000603)1.71040630
82Short tibia (HP:0005736)1.68958857
83Decreased muscle mass (HP:0003199)1.66822587
84Autoimmune thrombocytopenia (HP:0001973)1.65951717
85Abnormality of the pubic bones (HP:0003172)1.65582795
86Subcapsular cataract (HP:0000523)1.65402777
87Aplasia/Hypoplasia of the thymus (HP:0010515)1.62477767
88Abnormal tarsal ossification (HP:0008369)1.61672938
89Constricted visual fields (HP:0001133)1.61006932
90Abolished electroretinogram (ERG) (HP:0000550)1.60526368
91Cerebellar dysplasia (HP:0007033)1.60370861
92Absent septum pellucidum (HP:0001331)1.59680450
93Volvulus (HP:0002580)1.59261789
94Distal lower limb muscle weakness (HP:0009053)1.59213474
95Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.57607981
96Easy fatigability (HP:0003388)1.57463133
97Palpitations (HP:0001962)1.56979207
98Lipoatrophy (HP:0100578)1.56804908
99Irregular vertebral endplates (HP:0003301)1.56751119
100Epiphyseal dysplasia (HP:0002656)1.56484907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK16.88414457
2MUSK6.61791604
3EIF2AK34.27388091
4VRK24.05693012
5CCNB13.85323820
6CDK83.69515201
7MAP4K22.92192166
8MAPKAPK52.66972801
9ZAK2.31858181
10VRK11.92711262
11PLK41.70356993
12CDK91.68507747
13MAP3K71.53729005
14BUB11.46558834
15INSRR1.44761112
16MELK1.44527640
17IRAK31.43753388
18EIF2AK11.36484322
19PLK21.34691080
20BCKDK1.30340161
21PIK3CG1.19922450
22TESK21.07634925
23RPS6KA40.96453769
24PRKD20.95655381
25CDK40.95039440
26TESK10.94077783
27STK38L0.93088745
28BRD40.87013355
29CDC70.83716943
30CHEK20.83423918
31TRIM280.77328785
32PDK20.77255462
33ACVR1B0.76251366
34PKN10.75653558
35NUAK10.72834138
36PRKACB0.69497628
37TAF10.68465626
38PAK40.67385855
39PBK0.67385721
40PLK30.67124184
41MKNK10.67060999
42BMPR1B0.66648820
43EPHA30.64778602
44DDR20.64508301
45OXSR10.61109814
46KDR0.60301020
47MAP3K40.56738553
48PRKD10.55413861
49GRK10.54464314
50TTK0.53339511
51TNK20.53045080
52AURKB0.52634707
53CDK60.51999223
54SCYL20.51355385
55PIK3CA0.49554318
56MARK20.48682479
57SRPK10.48478699
58CSNK1G30.46338770
59PRKCE0.46045170
60BCR0.45137282
61PKN20.44588868
62FRK0.44102255
63CSNK1A1L0.43529700
64CSNK1G20.41952289
65IGF1R0.41847413
66MAP3K60.41186813
67CAMK2D0.40892335
68CAMK2B0.40204642
69MST1R0.39588951
70MAP2K70.39190567
71FER0.38792128
72ERBB40.36990817
73CAMK2G0.36439665
74CSNK1D0.36219968
75PTK2B0.36028621
76DMPK0.35066780
77TXK0.33298231
78CSNK2A10.32926509
79TGFBR10.32644568
80CAMK40.32279368
81PAK60.31946406
82ABL10.30401956
83ERBB30.29774060
84MAP2K10.29111484
85CDK30.28736322
86CDK70.28504119
87FLT30.28029420
88EIF2AK20.26367028
89EGFR0.24087872
90CHEK10.22313097
91STK390.21597319
92PAK20.21336173
93FGFR10.18852629
94PLK10.18801136
95CAMK2A0.18623220
96MARK10.17928809
97AURKA0.17573586
98CDK11A0.17215501
99PRKCZ0.16828061
100NEK60.15893191

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.06402307
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.95231394
3One carbon pool by folate_Homo sapiens_hsa006702.82258602
4Protein export_Homo sapiens_hsa030602.67450691
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.57583879
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57069619
7Spliceosome_Homo sapiens_hsa030402.27665589
8RNA degradation_Homo sapiens_hsa030182.21643261
9RNA transport_Homo sapiens_hsa030132.16852231
10Selenocompound metabolism_Homo sapiens_hsa004502.16488665
11Mismatch repair_Homo sapiens_hsa034302.14382899
12Fanconi anemia pathway_Homo sapiens_hsa034602.06300329
13Sulfur metabolism_Homo sapiens_hsa009201.99073988
14Ether lipid metabolism_Homo sapiens_hsa005651.96720803
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.88567739
16Base excision repair_Homo sapiens_hsa034101.87940778
17Homologous recombination_Homo sapiens_hsa034401.80701156
18TGF-beta signaling pathway_Homo sapiens_hsa043501.69341800
19DNA replication_Homo sapiens_hsa030301.65104607
20Primary immunodeficiency_Homo sapiens_hsa053401.61522397
21Cell cycle_Homo sapiens_hsa041101.61147336
22Nucleotide excision repair_Homo sapiens_hsa034201.61142996
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.60782867
24Propanoate metabolism_Homo sapiens_hsa006401.60058438
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56086887
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.53521391
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44697990
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38802256
29Pyrimidine metabolism_Homo sapiens_hsa002401.32176872
30Parkinsons disease_Homo sapiens_hsa050121.29003993
31Basal transcription factors_Homo sapiens_hsa030221.27762696
32ABC transporters_Homo sapiens_hsa020101.26724573
33Huntingtons disease_Homo sapiens_hsa050161.24515435
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.20063114
35p53 signaling pathway_Homo sapiens_hsa041151.15265778
36Cardiac muscle contraction_Homo sapiens_hsa042601.14083603
37Non-homologous end-joining_Homo sapiens_hsa034501.13666107
38Oocyte meiosis_Homo sapiens_hsa041141.11254632
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04875780
40Pyruvate metabolism_Homo sapiens_hsa006201.03173109
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02376051
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02070480
43Caffeine metabolism_Homo sapiens_hsa002321.02016304
44Peroxisome_Homo sapiens_hsa041460.99692116
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97360753
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95383599
47Tryptophan metabolism_Homo sapiens_hsa003800.94726096
48Hippo signaling pathway_Homo sapiens_hsa043900.94037459
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91644122
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.91343470
51Proteasome_Homo sapiens_hsa030500.90289325
52Olfactory transduction_Homo sapiens_hsa047400.89373785
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88804438
54Systemic lupus erythematosus_Homo sapiens_hsa053220.87650060
55Purine metabolism_Homo sapiens_hsa002300.87183358
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86574052
57Fatty acid biosynthesis_Homo sapiens_hsa000610.85996460
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85846540
59Oxidative phosphorylation_Homo sapiens_hsa001900.84997307
60Colorectal cancer_Homo sapiens_hsa052100.78874668
61Lysine degradation_Homo sapiens_hsa003100.78711029
62Alzheimers disease_Homo sapiens_hsa050100.77946344
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75716695
64HTLV-I infection_Homo sapiens_hsa051660.75036469
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74819814
66T cell receptor signaling pathway_Homo sapiens_hsa046600.74601851
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72517940
68Circadian rhythm_Homo sapiens_hsa047100.71955722
69Glycerolipid metabolism_Homo sapiens_hsa005610.70749454
70GABAergic synapse_Homo sapiens_hsa047270.69134704
71Fatty acid degradation_Homo sapiens_hsa000710.67763766
72Taste transduction_Homo sapiens_hsa047420.65573240
73Histidine metabolism_Homo sapiens_hsa003400.62856621
74Alcoholism_Homo sapiens_hsa050340.62525684
75Endocytosis_Homo sapiens_hsa041440.60007949
76Viral myocarditis_Homo sapiens_hsa054160.58906730
77Pancreatic secretion_Homo sapiens_hsa049720.55677464
78Pancreatic cancer_Homo sapiens_hsa052120.53951982
79Wnt signaling pathway_Homo sapiens_hsa043100.53482081
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52158561
81Adherens junction_Homo sapiens_hsa045200.52125952
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49858867
83Viral carcinogenesis_Homo sapiens_hsa052030.48652121
84Metabolic pathways_Homo sapiens_hsa011000.48124145
85Phototransduction_Homo sapiens_hsa047440.45351551
86Linoleic acid metabolism_Homo sapiens_hsa005910.45301523
87Herpes simplex infection_Homo sapiens_hsa051680.44237388
88Measles_Homo sapiens_hsa051620.42384930
89mRNA surveillance pathway_Homo sapiens_hsa030150.41655078
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41220694
91Legionellosis_Homo sapiens_hsa051340.41211974
92Hedgehog signaling pathway_Homo sapiens_hsa043400.38286201
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.37672026
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.37613890
95Basal cell carcinoma_Homo sapiens_hsa052170.37126190
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36382265
97Dilated cardiomyopathy_Homo sapiens_hsa054140.34873732
98beta-Alanine metabolism_Homo sapiens_hsa004100.33481665
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32581257
100Epstein-Barr virus infection_Homo sapiens_hsa051690.32309254

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