KRT18P65

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.83850890
2ncRNA 3-end processing (GO:0043628)6.46985518
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.87277571
4viral transcription (GO:0019083)5.12635148
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.10392665
6translational termination (GO:0006415)4.92149445
7prostanoid biosynthetic process (GO:0046457)4.71088130
8prostaglandin biosynthetic process (GO:0001516)4.71088130
9calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.63151028
10rRNA modification (GO:0000154)4.58911264
11translational elongation (GO:0006414)4.53602170
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.52771670
13protein targeting to ER (GO:0045047)4.44787497
14cotranslational protein targeting to membrane (GO:0006613)4.44192260
15regulation of mitochondrial translation (GO:0070129)4.37436153
16ATP synthesis coupled proton transport (GO:0015986)4.35557601
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.35557601
18protein localization to endoplasmic reticulum (GO:0070972)4.32164022
19chaperone-mediated protein transport (GO:0072321)4.28206566
20pyrimidine-containing compound transmembrane transport (GO:0072531)4.26917017
21water-soluble vitamin biosynthetic process (GO:0042364)4.25690227
22DNA replication checkpoint (GO:0000076)4.25574947
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.23113236
24artery smooth muscle contraction (GO:0014824)4.19328138
25ubiquinone biosynthetic process (GO:0006744)4.15892635
26viral life cycle (GO:0019058)4.07063681
27cyclooxygenase pathway (GO:0019371)3.97023407
28termination of RNA polymerase III transcription (GO:0006386)3.93962203
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.93962203
30coenzyme catabolic process (GO:0009109)3.88836104
31ribosomal small subunit assembly (GO:0000028)3.88764862
32translation (GO:0006412)3.88653422
33xenobiotic catabolic process (GO:0042178)3.84282079
34translational initiation (GO:0006413)3.84112221
35positive regulation of mitochondrial fission (GO:0090141)3.84006945
36rRNA methylation (GO:0031167)3.81045078
37ubiquinone metabolic process (GO:0006743)3.78599362
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.77496276
39cellular protein complex disassembly (GO:0043624)3.75919006
40ribonucleoprotein complex biogenesis (GO:0022613)3.70557379
41daunorubicin metabolic process (GO:0044597)3.63212390
42polyketide metabolic process (GO:0030638)3.63212390
43doxorubicin metabolic process (GO:0044598)3.63212390
44ribosomal large subunit biogenesis (GO:0042273)3.61658196
45quinone metabolic process (GO:1901661)3.54547847
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53654750
47prostaglandin metabolic process (GO:0006693)3.53513943
48prostanoid metabolic process (GO:0006692)3.53513943
49quinone biosynthetic process (GO:1901663)3.51709042
50maturation of SSU-rRNA (GO:0030490)3.50323311
51tonic smooth muscle contraction (GO:0014820)3.47843660
52base-excision repair, AP site formation (GO:0006285)3.46976262
53protein targeting to mitochondrion (GO:0006626)3.42234886
54pseudouridine synthesis (GO:0001522)3.37411732
55transcription from mitochondrial promoter (GO:0006390)3.36866600
56cytochrome complex assembly (GO:0017004)3.36349294
57cellular component biogenesis (GO:0044085)3.36283777
58intracellular protein transmembrane import (GO:0044743)3.33415243
59GTP biosynthetic process (GO:0006183)3.32661404
60regulation of oxidative phosphorylation (GO:0002082)3.31137096
61protein-cofactor linkage (GO:0018065)3.30683861
62galactose catabolic process (GO:0019388)3.27834767
63aminoglycoside antibiotic metabolic process (GO:0030647)3.23569406
64respiratory electron transport chain (GO:0022904)3.20641456
65protein K6-linked ubiquitination (GO:0085020)3.20006423
66regulation of cellular amino acid metabolic process (GO:0006521)3.19768750
67formation of translation preinitiation complex (GO:0001731)3.19356311
68electron transport chain (GO:0022900)3.18919115
69establishment of protein localization to mitochondrion (GO:0072655)3.18865694
70GDP-mannose metabolic process (GO:0019673)3.17479227
71protein localization to mitochondrion (GO:0070585)3.16100835
72protein complex biogenesis (GO:0070271)3.13822713
73protein targeting to membrane (GO:0006612)3.12534535
74protein complex disassembly (GO:0043241)3.08558035
75RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.08033778
76proteasome assembly (GO:0043248)3.07012824
77macrophage chemotaxis (GO:0048246)3.03240175
78mitochondrial respiratory chain complex assembly (GO:0033108)3.02836103
79establishment of integrated proviral latency (GO:0075713)3.02220783
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00700847
81histone mRNA metabolic process (GO:0008334)2.99552624
82galactose metabolic process (GO:0006012)2.99199365
83macromolecular complex disassembly (GO:0032984)2.96969727
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94478635
85negative regulation of transcription by competitive promoter binding (GO:0010944)2.90797881
86rRNA processing (GO:0006364)2.87928061
87UTP biosynthetic process (GO:0006228)2.86694012
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85690174
89negative regulation of ligase activity (GO:0051352)2.85690174
90uronic acid metabolic process (GO:0006063)2.85091380
91glucuronate metabolic process (GO:0019585)2.85091380
92maturation of 5.8S rRNA (GO:0000460)2.82844144
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80210569
94glutathione derivative biosynthetic process (GO:1901687)2.79388040
95glutathione derivative metabolic process (GO:1901685)2.79388040
96respiratory chain complex IV assembly (GO:0008535)2.79256159
97rRNA metabolic process (GO:0016072)2.76649499
98nuclear-transcribed mRNA catabolic process (GO:0000956)2.75816990
99regulation of mitochondrial fission (GO:0090140)2.72301956
100guanosine-containing compound biosynthetic process (GO:1901070)2.71939644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse9.61053197
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.23383213
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.72900701
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.54971114
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52121538
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.28440194
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.24458355
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21325243
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96979705
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.95800074
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.63894112
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53521482
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49550463
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42697281
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33668283
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.19411866
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.19411866
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.19411866
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19040408
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.11170219
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07425037
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00250285
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96017273
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.95885020
25XRN2_22483619_ChIP-Seq_HELA_Human1.93751710
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93119697
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89745843
28DCP1A_22483619_ChIP-Seq_HELA_Human1.89264121
29AR_21909140_ChIP-Seq_LNCAP_Human1.83443886
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81220970
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77330775
32TTF2_22483619_ChIP-Seq_HELA_Human1.77017107
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.75470384
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74816510
35VDR_23849224_ChIP-Seq_CD4+_Human1.74050967
36GABP_19822575_ChIP-Seq_HepG2_Human1.68765396
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66274053
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57031187
39FOXP3_21729870_ChIP-Seq_TREG_Human1.52469226
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42548403
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42242376
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41255759
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39871021
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37863623
45ZNF263_19887448_ChIP-Seq_K562_Human1.33690943
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32478168
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.29169810
48E2F7_22180533_ChIP-Seq_HELA_Human1.29154591
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27153166
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22684681
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19073247
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17245766
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14159367
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.11510393
55ELK1_19687146_ChIP-ChIP_HELA_Human1.11186274
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09561355
57CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09328208
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05394710
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05198806
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05181271
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01800885
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01346432
63ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97396187
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97286113
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97197939
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96612268
67KDM5A_27292631_Chip-Seq_BREAST_Human0.96261465
68SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92146842
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91394162
70NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90251113
71IRF1_19129219_ChIP-ChIP_H3396_Human0.86065785
72MYC_18940864_ChIP-ChIP_HL60_Human0.85721152
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85508846
74ELF5_23300383_ChIP-Seq_T47D_Human0.85505534
75ESR2_21235772_ChIP-Seq_MCF-7_Human0.84503588
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84297697
77SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83454932
78EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82917095
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82806248
80SOX17_20123909_ChIP-Seq_XEN_Mouse0.82527984
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82391024
82TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82201757
83PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81193033
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81065948
85E2F1_21310950_ChIP-Seq_MCF-7_Human0.79903464
86MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79169392
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.79142635
88BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78378878
89FOXP1_21924763_ChIP-Seq_HESCs_Human0.76696052
90OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75705146
91GATA4_25053715_ChIP-Seq_YYC3_Human0.75583574
92ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75439900
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75384797
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74554662
95EOMES_21245162_ChIP-Seq_HESCs_Human0.73701658
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73394638
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73179006
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73097460
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72160270
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.70020788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.33295125
2MP0005670_abnormal_white_adipose4.07780533
3MP0003878_abnormal_ear_physiology3.18281277
4MP0005377_hearing/vestibular/ear_phenot3.18281277
5MP0006035_abnormal_mitochondrial_morpho2.90561908
6MP0008058_abnormal_DNA_repair2.70949697
7MP0002138_abnormal_hepatobiliary_system2.57850066
8MP0004264_abnormal_extraembryonic_tissu2.53434598
9MP0005084_abnormal_gallbladder_morpholo2.52972627
10MP0003693_abnormal_embryo_hatching2.50919603
11MP0008875_abnormal_xenobiotic_pharmacok2.43083805
12MP0009379_abnormal_foot_pigmentation2.42283363
13MP0003186_abnormal_redox_activity2.42066308
14MP0006292_abnormal_olfactory_placode2.35914539
15MP0004957_abnormal_blastocyst_morpholog2.29103969
16MP0008789_abnormal_olfactory_epithelium2.26458263
17MP0006036_abnormal_mitochondrial_physio2.25721036
18MP0003718_maternal_effect2.21307136
19MP0002277_abnormal_respiratory_mucosa2.17740483
20MP0002139_abnormal_hepatobiliary_system2.14265338
21MP0002837_dystrophic_cardiac_calcinosis2.09237975
22MP0000015_abnormal_ear_pigmentation2.02300289
23MP0004133_heterotaxia1.99850685
24MP0008877_abnormal_DNA_methylation1.96526071
25MP0001666_abnormal_nutrient_absorption1.87770751
26MP0002928_abnormal_bile_duct1.81099118
27MP0000538_abnormal_urinary_bladder1.79630843
28MP0002938_white_spotting1.78358755
29MP0010030_abnormal_orbit_morphology1.72210158
30MP0003938_abnormal_ear_development1.69488059
31MP0005394_taste/olfaction_phenotype1.68520992
32MP0005499_abnormal_olfactory_system1.68520992
33MP0003252_abnormal_bile_duct1.68286487
34MP0003787_abnormal_imprinting1.59086169
35MP0002796_impaired_skin_barrier1.47200231
36MP0002098_abnormal_vibrissa_morphology1.46221140
37MP0001881_abnormal_mammary_gland1.41299151
38MP0000383_abnormal_hair_follicle1.39503163
39MP0010386_abnormal_urinary_bladder1.37919235
40MP0003786_premature_aging1.37703847
41MP0005501_abnormal_skin_physiology1.36865057
42MP0000537_abnormal_urethra_morphology1.30127508
43MP0004145_abnormal_muscle_electrophysio1.27043464
44MP0008932_abnormal_embryonic_tissue1.24862825
45MP0002638_abnormal_pupillary_reflex1.23476846
46MP0004019_abnormal_vitamin_homeostasis1.19185024
47MP0005367_renal/urinary_system_phenotyp1.18226150
48MP0000516_abnormal_urinary_system1.18226150
49MP0001270_distended_abdomen1.17791031
50MP0003315_abnormal_perineum_morphology1.15713609
51MP0008057_abnormal_DNA_replication1.15316685
52MP0001764_abnormal_homeostasis1.15043352
53MP0003077_abnormal_cell_cycle1.10559196
54MP0005408_hypopigmentation1.10449444
55MP0010678_abnormal_skin_adnexa1.08846429
56MP0000358_abnormal_cell_content/1.01137181
57MP0005332_abnormal_amino_acid0.99628552
58MP0008872_abnormal_physiological_respon0.99478788
59MP0005636_abnormal_mineral_homeostasis0.98928173
60MP0001293_anophthalmia0.97874792
61MP0003279_aneurysm0.97208683
62MP0003638_abnormal_response/metabolism_0.95921730
63MP0002177_abnormal_outer_ear0.95006921
64MP0003936_abnormal_reproductive_system0.94140228
65MP0000627_abnormal_mammary_gland0.94123829
66MP0001905_abnormal_dopamine_level0.94066098
67MP0001697_abnormal_embryo_size0.91709496
68MP0010094_abnormal_chromosome_stability0.91580031
69MP0005410_abnormal_fertilization0.91337317
70MP0003119_abnormal_digestive_system0.89717192
71MP0003111_abnormal_nucleus_morphology0.89476928
72MP0000762_abnormal_tongue_morphology0.88636936
73MP0003879_abnormal_hair_cell0.88270279
74MP0004233_abnormal_muscle_weight0.85879155
75MP0003866_abnormal_defecation0.85721882
76MP0001529_abnormal_vocalization0.83509522
77MP0002160_abnormal_reproductive_system0.82657722
78MP0000647_abnormal_sebaceous_gland0.81695340
79MP0004147_increased_porphyrin_level0.81216591
80MP0003943_abnormal_hepatobiliary_system0.81081711
81MP0003890_abnormal_embryonic-extraembry0.78601304
82MP0010771_integument_phenotype0.78276725
83MP0001873_stomach_inflammation0.76093126
84MP0002233_abnormal_nose_morphology0.73599613
85MP0010234_abnormal_vibrissa_follicle0.73166338
86MP0000049_abnormal_middle_ear0.71845509
87MP0004885_abnormal_endolymph0.69501360
88MP0001756_abnormal_urination0.67901113
89MP0000467_abnormal_esophagus_morphology0.67833955
90MP0005058_abnormal_lysosome_morphology0.66882326
91MP0005083_abnormal_biliary_tract0.66403769
92MP0005389_reproductive_system_phenotype0.65995335
93MP0005220_abnormal_exocrine_pancreas0.65782740
94MP0003191_abnormal_cellular_cholesterol0.65700562
95MP0003937_abnormal_limbs/digits/tail_de0.65027953
96MP0005075_abnormal_melanosome_morpholog0.64143114
97MP0002095_abnormal_skin_pigmentation0.63644094
98MP0002697_abnormal_eye_size0.60251354
99MP0000367_abnormal_coat/_hair0.59671654
100MP0002132_abnormal_respiratory_system0.59541229

Predicted human phenotypes

RankGene SetZ-score
1Hypoplastic pelvis (HP:0008839)3.76354981
2Decreased activity of mitochondrial respiratory chain (HP:0008972)3.69994104
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.69994104
4Increased hepatocellular lipid droplets (HP:0006565)3.67461118
5Lipid accumulation in hepatocytes (HP:0006561)3.61981505
6Renal Fanconi syndrome (HP:0001994)3.60416896
7Acute necrotizing encephalopathy (HP:0006965)3.55694264
8Adrenal hypoplasia (HP:0000835)3.52020681
93-Methylglutaconic aciduria (HP:0003535)3.50441906
10Hyperglycinemia (HP:0002154)3.49513301
11Abnormal mitochondria in muscle tissue (HP:0008316)3.47788613
12Mitochondrial inheritance (HP:0001427)3.46271139
13Increased CSF lactate (HP:0002490)3.35070940
14Methylmalonic acidemia (HP:0002912)3.31559213
15Polydipsia (HP:0001959)3.25059319
16Abnormal drinking behavior (HP:0030082)3.25059319
17Microvesicular hepatic steatosis (HP:0001414)3.19246829
18Acute encephalopathy (HP:0006846)3.15929458
19Abnormality of methionine metabolism (HP:0010901)3.07262180
20Progressive macrocephaly (HP:0004481)2.98853970
21Potter facies (HP:0002009)2.98658253
22Facial shape deformation (HP:0011334)2.98658253
23Reduced subcutaneous adipose tissue (HP:0003758)2.93869813
24Increased intramyocellular lipid droplets (HP:0012240)2.93392684
25Tubulointerstitial fibrosis (HP:0005576)2.89731350
26Abnormality of serum amino acid levels (HP:0003112)2.82209066
27Lactic acidosis (HP:0003128)2.77845086
28Abnormality of cells of the erythroid lineage (HP:0012130)2.77744656
29Increased serum lactate (HP:0002151)2.76277803
30Decreased electroretinogram (ERG) amplitude (HP:0000654)2.73010260
31Glycosuria (HP:0003076)2.71625634
32Abnormality of urine glucose concentration (HP:0011016)2.71625634
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.69702329
34Macrocytic anemia (HP:0001972)2.68771227
35Abnormal number of erythroid precursors (HP:0012131)2.68322719
36Abnormality of renal resorption (HP:0011038)2.67445974
37Hepatocellular necrosis (HP:0001404)2.66519809
38Abnormal biliary tract physiology (HP:0012439)2.66039853
39Bile duct proliferation (HP:0001408)2.66039853
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65414462
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.61754569
42Methylmalonic aciduria (HP:0012120)2.60731048
43Polyuria (HP:0000103)2.59869068
44Abnormality of alanine metabolism (HP:0010916)2.59520738
45Hyperalaninemia (HP:0003348)2.59520738
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59520738
47Increased muscle lipid content (HP:0009058)2.58297042
48Exertional dyspnea (HP:0002875)2.56657222
49Cerebral edema (HP:0002181)2.55621817
50Hyperphosphatemia (HP:0002905)2.54544468
51Pancytopenia (HP:0001876)2.54502648
52Dry hair (HP:0011359)2.53383725
53Abnormality of the renal cortex (HP:0011035)2.52450226
54Respiratory difficulties (HP:0002880)2.51902724
55Patent foramen ovale (HP:0001655)2.47534791
56Exercise intolerance (HP:0003546)2.44628571
57Pancreatic cysts (HP:0001737)2.43385123
58Enlarged kidneys (HP:0000105)2.40314048
59Stenosis of the external auditory canal (HP:0000402)2.38025014
60Reduced antithrombin III activity (HP:0001976)2.36635373
61Hepatic necrosis (HP:0002605)2.34211335
62Lethargy (HP:0001254)2.32006063
63Leukodystrophy (HP:0002415)2.31543867
64Progressive muscle weakness (HP:0003323)2.30594309
65Abnormality of aromatic amino acid family metabolism (HP:0004338)2.29083386
66Rough bone trabeculation (HP:0100670)2.28944570
67Aplastic anemia (HP:0001915)2.27562987
68Abnormality of renal excretion (HP:0011036)2.27005536
69Supernumerary spleens (HP:0009799)2.24138264
70Hyperphosphaturia (HP:0003109)2.23186714
71CNS demyelination (HP:0007305)2.22197366
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21711991
73Congenital, generalized hypertrichosis (HP:0004540)2.15308178
74Pancreatic fibrosis (HP:0100732)2.13868090
75Abnormality of serine family amino acid metabolism (HP:0010894)2.12416256
76Abnormality of glycine metabolism (HP:0010895)2.12416256
77Tinnitus (HP:0000360)2.09140050
78Abnormal urine output (HP:0012590)2.08297220
79Brushfield spots (HP:0001088)2.07716762
80Abnormality of the vitamin B12 metabolism (HP:0004341)2.07586633
81Abnormality of sulfur amino acid metabolism (HP:0004339)2.03883470
82Renal tubular dysfunction (HP:0000124)2.03209289
83Optic disc pallor (HP:0000543)2.02110529
84Micronodular cirrhosis (HP:0001413)1.96771270
85Type I transferrin isoform profile (HP:0003642)1.95149185
86Respiratory failure (HP:0002878)1.94870713
87Hyperglycemia (HP:0003074)1.93924132
88Abnormality of vitamin B metabolism (HP:0004340)1.93865153
89Cystic liver disease (HP:0006706)1.92926261
90Abnormal urine phosphate concentration (HP:0012599)1.92176413
91Down-sloping shoulders (HP:0200021)1.91568739
92Hyperglycinuria (HP:0003108)1.91224994
93Abnormal biliary tract morphology (HP:0012440)1.89042147
94Split foot (HP:0001839)1.87729541
95Abnormal auditory evoked potentials (HP:0006958)1.84832176
96Albinism (HP:0001022)1.84813534
97Dicarboxylic aciduria (HP:0003215)1.81629523
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81629523
99Abnormal trabecular bone morphology (HP:0100671)1.81573153
100Pili torti (HP:0003777)1.80681333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.75599614
2EIF2AK13.23733247
3RPS6KB23.15247909
4CDC73.09810058
5MST43.01460135
6NME22.99032602
7PDK22.93160730
8VRK22.75637439
9MAP3K122.69696410
10PBK2.59870676
11CDK192.42479965
12PINK12.37505808
13STK162.33909175
14MAPKAPK32.32888344
15PIK3CA2.28938079
16OXSR12.26921309
17TLK12.22487461
18NEK12.21539480
19TESK21.89424757
20BCKDK1.76314179
21ABL21.73469626
22STK391.56940961
23BUB11.54384153
24TESK11.48945890
25PAK41.47870066
26LIMK11.37740340
27NME11.33693666
28SCYL21.32860269
29CSNK1G31.32082471
30CSNK1G11.29881969
31STK381.23852970
32MELK1.19070699
33SRPK11.18467400
34VRK11.14586070
35DYRK31.12657734
36MAP3K131.09643572
37TRIM281.07676092
38CSNK1A1L1.04261306
39MYLK1.02179344
40BMPR1B1.00533026
41STK41.00268134
42TAOK30.97306235
43CSNK1G20.95066164
44PLK10.94986425
45WEE10.90594369
46RPS6KA50.89241580
47WNK40.87674526
48GRK10.82104213
49PRKCI0.78775708
50LMTK20.75054195
51ADRBK20.74586322
52PASK0.73033206
53FGR0.66789891
54CDK80.64726085
55AURKA0.64430025
56PHKG10.64167712
57PHKG20.64167712
58NUAK10.62975581
59TGFBR10.62436229
60BRSK20.60900029
61AURKB0.60616122
62CAMK2D0.60530452
63ERBB40.60324230
64FRK0.59036475
65MAP2K20.58288668
66ILK0.57817638
67MAP3K80.57807282
68CAMK2G0.56556794
69MAP3K70.56092877
70CDK90.55574899
71ZAK0.53076559
72CSNK1A10.52495335
73BRSK10.52028938
74DAPK30.51651758
75PLK40.51068471
76DAPK10.50371568
77MST1R0.49999472
78JAK30.49489067
79PLK30.49384350
80PAK10.47279897
81CSNK2A10.43416682
82TNIK0.43394415
83AKT20.43315702
84TTK0.43232119
85PRKCE0.42603903
86CAMK2B0.41897255
87CDK70.41835310
88KDR0.40522204
89IKBKB0.39847595
90PIM20.39027995
91CASK0.36433866
92CHEK20.36291616
93CSNK2A20.35382851
94RPS6KA40.31957339
95PRKCD0.31805829
96MKNK20.29470782
97ADRBK10.29420675
98TSSK60.28988079
99CLK10.27447448
100MAP4K20.26646286

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.80171441
2Proteasome_Homo sapiens_hsa030503.85238663
3Oxidative phosphorylation_Homo sapiens_hsa001903.46796439
4Parkinsons disease_Homo sapiens_hsa050122.55572785
5RNA polymerase_Homo sapiens_hsa030202.43524331
6DNA replication_Homo sapiens_hsa030302.27428056
7Fatty acid elongation_Homo sapiens_hsa000622.25038875
8Glutathione metabolism_Homo sapiens_hsa004802.03342388
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02494287
10Base excision repair_Homo sapiens_hsa034101.95621529
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.92064164
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88313593
13Protein export_Homo sapiens_hsa030601.86814328
14Collecting duct acid secretion_Homo sapiens_hsa049661.84662136
15Huntingtons disease_Homo sapiens_hsa050161.77515206
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.75267024
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72467571
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72249339
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68708364
20One carbon pool by folate_Homo sapiens_hsa006701.67161472
21Chemical carcinogenesis_Homo sapiens_hsa052041.63083451
22Folate biosynthesis_Homo sapiens_hsa007901.55578032
23Pyrimidine metabolism_Homo sapiens_hsa002401.55388531
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54091161
25Sulfur relay system_Homo sapiens_hsa041221.53784122
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.48686124
27Alzheimers disease_Homo sapiens_hsa050101.46069037
28Fanconi anemia pathway_Homo sapiens_hsa034601.45900973
29Mismatch repair_Homo sapiens_hsa034301.44823065
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.42960403
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42548037
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40656175
33Homologous recombination_Homo sapiens_hsa034401.35450529
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34405042
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.32665090
36Peroxisome_Homo sapiens_hsa041461.29697615
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29514914
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27503927
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27040989
40Vibrio cholerae infection_Homo sapiens_hsa051101.26297068
41Galactose metabolism_Homo sapiens_hsa000521.22706938
42Nucleotide excision repair_Homo sapiens_hsa034201.22471579
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20232093
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19270546
45RNA transport_Homo sapiens_hsa030131.19106176
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18761139
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18294404
48RNA degradation_Homo sapiens_hsa030181.18245316
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14970095
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12495353
51Cardiac muscle contraction_Homo sapiens_hsa042601.07759280
52Spliceosome_Homo sapiens_hsa030401.07586718
53Starch and sucrose metabolism_Homo sapiens_hsa005001.01994123
54Retinol metabolism_Homo sapiens_hsa008300.98901270
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98652782
56Arachidonic acid metabolism_Homo sapiens_hsa005900.97878804
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95783620
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92931358
59Histidine metabolism_Homo sapiens_hsa003400.88679118
60Metabolic pathways_Homo sapiens_hsa011000.87605377
61Vitamin B6 metabolism_Homo sapiens_hsa007500.86308995
62Propanoate metabolism_Homo sapiens_hsa006400.85368952
63Purine metabolism_Homo sapiens_hsa002300.83270923
64Vitamin digestion and absorption_Homo sapiens_hsa049770.74388530
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73536668
66Basal transcription factors_Homo sapiens_hsa030220.73209225
67Caffeine metabolism_Homo sapiens_hsa002320.70801634
68Selenocompound metabolism_Homo sapiens_hsa004500.69058767
69Pyruvate metabolism_Homo sapiens_hsa006200.68052352
70Carbon metabolism_Homo sapiens_hsa012000.67726330
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67584458
72beta-Alanine metabolism_Homo sapiens_hsa004100.65591126
73Fat digestion and absorption_Homo sapiens_hsa049750.64887934
74Biosynthesis of amino acids_Homo sapiens_hsa012300.64547687
75Tyrosine metabolism_Homo sapiens_hsa003500.64511683
76Sulfur metabolism_Homo sapiens_hsa009200.64400385
77Synaptic vesicle cycle_Homo sapiens_hsa047210.53707513
78Tryptophan metabolism_Homo sapiens_hsa003800.53000022
79Non-homologous end-joining_Homo sapiens_hsa034500.51981348
80Tight junction_Homo sapiens_hsa045300.51696117
81Pentose phosphate pathway_Homo sapiens_hsa000300.49382430
82TGF-beta signaling pathway_Homo sapiens_hsa043500.45644071
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.42035319
84Hedgehog signaling pathway_Homo sapiens_hsa043400.41274051
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39270889
86Steroid biosynthesis_Homo sapiens_hsa001000.38194187
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35701687
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34790294
89N-Glycan biosynthesis_Homo sapiens_hsa005100.33541265
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31638548
91Fructose and mannose metabolism_Homo sapiens_hsa000510.31540226
92Protein digestion and absorption_Homo sapiens_hsa049740.31171997
93Ether lipid metabolism_Homo sapiens_hsa005650.29134531
94Lysosome_Homo sapiens_hsa041420.24318045
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.24143675
96Basal cell carcinoma_Homo sapiens_hsa052170.24040649
97Arginine and proline metabolism_Homo sapiens_hsa003300.22709227
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21803548
99p53 signaling pathway_Homo sapiens_hsa041150.21338892
100Cell cycle_Homo sapiens_hsa041100.19284896

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