ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	6.83850890
2	ncRNA 3-end processing (GO:0043628)	6.46985518
3	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.87277571
4	viral transcription (GO:0019083)	5.12635148
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.10392665
6	translational termination (GO:0006415)	4.92149445
7	prostanoid biosynthetic process (GO:0046457)	4.71088130
8	prostaglandin biosynthetic process (GO:0001516)	4.71088130
9	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	4.63151028
10	rRNA modification (GO:0000154)	4.58911264
11	translational elongation (GO:0006414)	4.53602170
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.52771670
13	protein targeting to ER (GO:0045047)	4.44787497
14	cotranslational protein targeting to membrane (GO:0006613)	4.44192260
15	regulation of mitochondrial translation (GO:0070129)	4.37436153
16	ATP synthesis coupled proton transport (GO:0015986)	4.35557601
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.35557601
18	protein localization to endoplasmic reticulum (GO:0070972)	4.32164022
19	chaperone-mediated protein transport (GO:0072321)	4.28206566
20	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.26917017
21	water-soluble vitamin biosynthetic process (GO:0042364)	4.25690227
22	DNA replication checkpoint (GO:0000076)	4.25574947
23	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.23113236
24	artery smooth muscle contraction (GO:0014824)	4.19328138
25	ubiquinone biosynthetic process (GO:0006744)	4.15892635
26	viral life cycle (GO:0019058)	4.07063681
27	cyclooxygenase pathway (GO:0019371)	3.97023407
28	termination of RNA polymerase III transcription (GO:0006386)	3.93962203
29	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.93962203
30	coenzyme catabolic process (GO:0009109)	3.88836104
31	ribosomal small subunit assembly (GO:0000028)	3.88764862
32	translation (GO:0006412)	3.88653422
33	xenobiotic catabolic process (GO:0042178)	3.84282079
34	translational initiation (GO:0006413)	3.84112221
35	positive regulation of mitochondrial fission (GO:0090141)	3.84006945
36	rRNA methylation (GO:0031167)	3.81045078
37	ubiquinone metabolic process (GO:0006743)	3.78599362
38	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.77496276
39	cellular protein complex disassembly (GO:0043624)	3.75919006
40	ribonucleoprotein complex biogenesis (GO:0022613)	3.70557379
41	daunorubicin metabolic process (GO:0044597)	3.63212390
42	polyketide metabolic process (GO:0030638)	3.63212390
43	doxorubicin metabolic process (GO:0044598)	3.63212390
44	ribosomal large subunit biogenesis (GO:0042273)	3.61658196
45	quinone metabolic process (GO:1901661)	3.54547847
46	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.53654750
47	prostaglandin metabolic process (GO:0006693)	3.53513943
48	prostanoid metabolic process (GO:0006692)	3.53513943
49	quinone biosynthetic process (GO:1901663)	3.51709042
50	maturation of SSU-rRNA (GO:0030490)	3.50323311
51	tonic smooth muscle contraction (GO:0014820)	3.47843660
52	base-excision repair, AP site formation (GO:0006285)	3.46976262
53	protein targeting to mitochondrion (GO:0006626)	3.42234886
54	pseudouridine synthesis (GO:0001522)	3.37411732
55	transcription from mitochondrial promoter (GO:0006390)	3.36866600
56	cytochrome complex assembly (GO:0017004)	3.36349294
57	cellular component biogenesis (GO:0044085)	3.36283777
58	intracellular protein transmembrane import (GO:0044743)	3.33415243
59	GTP biosynthetic process (GO:0006183)	3.32661404
60	regulation of oxidative phosphorylation (GO:0002082)	3.31137096
61	protein-cofactor linkage (GO:0018065)	3.30683861
62	galactose catabolic process (GO:0019388)	3.27834767
63	aminoglycoside antibiotic metabolic process (GO:0030647)	3.23569406
64	respiratory electron transport chain (GO:0022904)	3.20641456
65	protein K6-linked ubiquitination (GO:0085020)	3.20006423
66	regulation of cellular amino acid metabolic process (GO:0006521)	3.19768750
67	formation of translation preinitiation complex (GO:0001731)	3.19356311
68	electron transport chain (GO:0022900)	3.18919115
69	establishment of protein localization to mitochondrion (GO:0072655)	3.18865694
70	GDP-mannose metabolic process (GO:0019673)	3.17479227
71	protein localization to mitochondrion (GO:0070585)	3.16100835
72	protein complex biogenesis (GO:0070271)	3.13822713
73	protein targeting to membrane (GO:0006612)	3.12534535
74	protein complex disassembly (GO:0043241)	3.08558035
75	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	3.08033778
76	proteasome assembly (GO:0043248)	3.07012824
77	macrophage chemotaxis (GO:0048246)	3.03240175
78	mitochondrial respiratory chain complex assembly (GO:0033108)	3.02836103
79	establishment of integrated proviral latency (GO:0075713)	3.02220783
80	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.00700847
81	histone mRNA metabolic process (GO:0008334)	2.99552624
82	galactose metabolic process (GO:0006012)	2.99199365
83	macromolecular complex disassembly (GO:0032984)	2.96969727
84	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.94478635
85	negative regulation of transcription by competitive promoter binding (GO:0010944)	2.90797881
86	rRNA processing (GO:0006364)	2.87928061
87	UTP biosynthetic process (GO:0006228)	2.86694012
88	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.85690174
89	negative regulation of ligase activity (GO:0051352)	2.85690174
90	uronic acid metabolic process (GO:0006063)	2.85091380
91	glucuronate metabolic process (GO:0019585)	2.85091380
92	maturation of 5.8S rRNA (GO:0000460)	2.82844144
93	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.80210569
94	glutathione derivative biosynthetic process (GO:1901687)	2.79388040
95	glutathione derivative metabolic process (GO:1901685)	2.79388040
96	respiratory chain complex IV assembly (GO:0008535)	2.79256159
97	rRNA metabolic process (GO:0016072)	2.76649499
98	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.75816990
99	regulation of mitochondrial fission (GO:0090140)	2.72301956
100	guanosine-containing compound biosynthetic process (GO:1901070)	2.71939644

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	9.61053197
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.23383213
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.72900701
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.54971114
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.52121538
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.28440194
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.24458355
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.21325243
9	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.96979705
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.95800074
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.63894112
12	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.53521482
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.49550463
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.42697281
15	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.33668283
16	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.19411866
17	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.19411866
18	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.19411866
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.19040408
20	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.11170219
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.07425037
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.00250285
23	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.96017273
24	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.95885020
25	XRN2_22483619_ChIP-Seq_HELA_Human	1.93751710
26	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.93119697
27	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.89745843
28	DCP1A_22483619_ChIP-Seq_HELA_Human	1.89264121
29	AR_21909140_ChIP-Seq_LNCAP_Human	1.83443886
30	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.81220970
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.77330775
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.77017107
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.75470384
34	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.74816510
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.74050967
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.68765396
37	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.66274053
38	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.57031187
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.52469226
40	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.42548403
41	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.42242376
42	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.41255759
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.39871021
44	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.37863623
45	ZNF263_19887448_ChIP-Seq_K562_Human	1.33690943
46	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.32478168
47	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.29169810
48	E2F7_22180533_ChIP-Seq_HELA_Human	1.29154591
49	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.27153166
50	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.22684681
51	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.19073247
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.17245766
53	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.14159367
54	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.11510393
55	ELK1_19687146_ChIP-ChIP_HELA_Human	1.11186274
56	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.09561355
57	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.09328208
58	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.05394710
59	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.05198806
60	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.05181271
61	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.01800885
62	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.01346432
63	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.97396187
64	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.97286113
65	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.97197939
66	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.96612268
67	KDM5A_27292631_Chip-Seq_BREAST_Human	0.96261465
68	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.92146842
69	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91394162
70	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.90251113
71	IRF1_19129219_ChIP-ChIP_H3396_Human	0.86065785
72	MYC_18940864_ChIP-ChIP_HL60_Human	0.85721152
73	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.85508846
74	ELF5_23300383_ChIP-Seq_T47D_Human	0.85505534
75	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.84503588
76	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.84297697
77	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.83454932
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.82917095
79	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.82806248
80	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.82527984
81	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.82391024
82	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.82201757
83	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.81193033
84	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.81065948
85	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.79903464
86	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.79169392
87	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.79142635
88	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.78378878
89	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.76696052
90	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.75705146
91	GATA4_25053715_ChIP-Seq_YYC3_Human	0.75583574
92	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.75439900
93	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.75384797
94	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.74554662
95	EOMES_21245162_ChIP-Seq_HESCs_Human	0.73701658
96	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.73394638
97	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.73179006
98	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.73097460
99	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.72160270
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.70020788

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.33295125
2	MP0005670_abnormal_white_adipose	4.07780533
3	MP0003878_abnormal_ear_physiology	3.18281277
4	MP0005377_hearing/vestibular/ear_phenot	3.18281277
5	MP0006035_abnormal_mitochondrial_morpho	2.90561908
6	MP0008058_abnormal_DNA_repair	2.70949697
7	MP0002138_abnormal_hepatobiliary_system	2.57850066
8	MP0004264_abnormal_extraembryonic_tissu	2.53434598
9	MP0005084_abnormal_gallbladder_morpholo	2.52972627
10	MP0003693_abnormal_embryo_hatching	2.50919603
11	MP0008875_abnormal_xenobiotic_pharmacok	2.43083805
12	MP0009379_abnormal_foot_pigmentation	2.42283363
13	MP0003186_abnormal_redox_activity	2.42066308
14	MP0006292_abnormal_olfactory_placode	2.35914539
15	MP0004957_abnormal_blastocyst_morpholog	2.29103969
16	MP0008789_abnormal_olfactory_epithelium	2.26458263
17	MP0006036_abnormal_mitochondrial_physio	2.25721036
18	MP0003718_maternal_effect	2.21307136
19	MP0002277_abnormal_respiratory_mucosa	2.17740483
20	MP0002139_abnormal_hepatobiliary_system	2.14265338
21	MP0002837_dystrophic_cardiac_calcinosis	2.09237975
22	MP0000015_abnormal_ear_pigmentation	2.02300289
23	MP0004133_heterotaxia	1.99850685
24	MP0008877_abnormal_DNA_methylation	1.96526071
25	MP0001666_abnormal_nutrient_absorption	1.87770751
26	MP0002928_abnormal_bile_duct	1.81099118
27	MP0000538_abnormal_urinary_bladder	1.79630843
28	MP0002938_white_spotting	1.78358755
29	MP0010030_abnormal_orbit_morphology	1.72210158
30	MP0003938_abnormal_ear_development	1.69488059
31	MP0005394_taste/olfaction_phenotype	1.68520992
32	MP0005499_abnormal_olfactory_system	1.68520992
33	MP0003252_abnormal_bile_duct	1.68286487
34	MP0003787_abnormal_imprinting	1.59086169
35	MP0002796_impaired_skin_barrier	1.47200231
36	MP0002098_abnormal_vibrissa_morphology	1.46221140
37	MP0001881_abnormal_mammary_gland	1.41299151
38	MP0000383_abnormal_hair_follicle	1.39503163
39	MP0010386_abnormal_urinary_bladder	1.37919235
40	MP0003786_premature_aging	1.37703847
41	MP0005501_abnormal_skin_physiology	1.36865057
42	MP0000537_abnormal_urethra_morphology	1.30127508
43	MP0004145_abnormal_muscle_electrophysio	1.27043464
44	MP0008932_abnormal_embryonic_tissue	1.24862825
45	MP0002638_abnormal_pupillary_reflex	1.23476846
46	MP0004019_abnormal_vitamin_homeostasis	1.19185024
47	MP0005367_renal/urinary_system_phenotyp	1.18226150
48	MP0000516_abnormal_urinary_system	1.18226150
49	MP0001270_distended_abdomen	1.17791031
50	MP0003315_abnormal_perineum_morphology	1.15713609
51	MP0008057_abnormal_DNA_replication	1.15316685
52	MP0001764_abnormal_homeostasis	1.15043352
53	MP0003077_abnormal_cell_cycle	1.10559196
54	MP0005408_hypopigmentation	1.10449444
55	MP0010678_abnormal_skin_adnexa	1.08846429
56	MP0000358_abnormal_cell_content/	1.01137181
57	MP0005332_abnormal_amino_acid	0.99628552
58	MP0008872_abnormal_physiological_respon	0.99478788
59	MP0005636_abnormal_mineral_homeostasis	0.98928173
60	MP0001293_anophthalmia	0.97874792
61	MP0003279_aneurysm	0.97208683
62	MP0003638_abnormal_response/metabolism_	0.95921730
63	MP0002177_abnormal_outer_ear	0.95006921
64	MP0003936_abnormal_reproductive_system	0.94140228
65	MP0000627_abnormal_mammary_gland	0.94123829
66	MP0001905_abnormal_dopamine_level	0.94066098
67	MP0001697_abnormal_embryo_size	0.91709496
68	MP0010094_abnormal_chromosome_stability	0.91580031
69	MP0005410_abnormal_fertilization	0.91337317
70	MP0003119_abnormal_digestive_system	0.89717192
71	MP0003111_abnormal_nucleus_morphology	0.89476928
72	MP0000762_abnormal_tongue_morphology	0.88636936
73	MP0003879_abnormal_hair_cell	0.88270279
74	MP0004233_abnormal_muscle_weight	0.85879155
75	MP0003866_abnormal_defecation	0.85721882
76	MP0001529_abnormal_vocalization	0.83509522
77	MP0002160_abnormal_reproductive_system	0.82657722
78	MP0000647_abnormal_sebaceous_gland	0.81695340
79	MP0004147_increased_porphyrin_level	0.81216591
80	MP0003943_abnormal_hepatobiliary_system	0.81081711
81	MP0003890_abnormal_embryonic-extraembry	0.78601304
82	MP0010771_integument_phenotype	0.78276725
83	MP0001873_stomach_inflammation	0.76093126
84	MP0002233_abnormal_nose_morphology	0.73599613
85	MP0010234_abnormal_vibrissa_follicle	0.73166338
86	MP0000049_abnormal_middle_ear	0.71845509
87	MP0004885_abnormal_endolymph	0.69501360
88	MP0001756_abnormal_urination	0.67901113
89	MP0000467_abnormal_esophagus_morphology	0.67833955
90	MP0005058_abnormal_lysosome_morphology	0.66882326
91	MP0005083_abnormal_biliary_tract	0.66403769
92	MP0005389_reproductive_system_phenotype	0.65995335
93	MP0005220_abnormal_exocrine_pancreas	0.65782740
94	MP0003191_abnormal_cellular_cholesterol	0.65700562
95	MP0003937_abnormal_limbs/digits/tail_de	0.65027953
96	MP0005075_abnormal_melanosome_morpholog	0.64143114
97	MP0002095_abnormal_skin_pigmentation	0.63644094
98	MP0002697_abnormal_eye_size	0.60251354
99	MP0000367_abnormal_coat/_hair	0.59671654
100	MP0002132_abnormal_respiratory_system	0.59541229

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplastic pelvis (HP:0008839)	3.76354981
2	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.69994104
3	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.69994104
4	Increased hepatocellular lipid droplets (HP:0006565)	3.67461118
5	Lipid accumulation in hepatocytes (HP:0006561)	3.61981505
6	Renal Fanconi syndrome (HP:0001994)	3.60416896
7	Acute necrotizing encephalopathy (HP:0006965)	3.55694264
8	Adrenal hypoplasia (HP:0000835)	3.52020681
9	3-Methylglutaconic aciduria (HP:0003535)	3.50441906
10	Hyperglycinemia (HP:0002154)	3.49513301
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.47788613
12	Mitochondrial inheritance (HP:0001427)	3.46271139
13	Increased CSF lactate (HP:0002490)	3.35070940
14	Methylmalonic acidemia (HP:0002912)	3.31559213
15	Polydipsia (HP:0001959)	3.25059319
16	Abnormal drinking behavior (HP:0030082)	3.25059319
17	Microvesicular hepatic steatosis (HP:0001414)	3.19246829
18	Acute encephalopathy (HP:0006846)	3.15929458
19	Abnormality of methionine metabolism (HP:0010901)	3.07262180
20	Progressive macrocephaly (HP:0004481)	2.98853970
21	Potter facies (HP:0002009)	2.98658253
22	Facial shape deformation (HP:0011334)	2.98658253
23	Reduced subcutaneous adipose tissue (HP:0003758)	2.93869813
24	Increased intramyocellular lipid droplets (HP:0012240)	2.93392684
25	Tubulointerstitial fibrosis (HP:0005576)	2.89731350
26	Abnormality of serum amino acid levels (HP:0003112)	2.82209066
27	Lactic acidosis (HP:0003128)	2.77845086
28	Abnormality of cells of the erythroid lineage (HP:0012130)	2.77744656
29	Increased serum lactate (HP:0002151)	2.76277803
30	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.73010260
31	Glycosuria (HP:0003076)	2.71625634
32	Abnormality of urine glucose concentration (HP:0011016)	2.71625634
33	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.69702329
34	Macrocytic anemia (HP:0001972)	2.68771227
35	Abnormal number of erythroid precursors (HP:0012131)	2.68322719
36	Abnormality of renal resorption (HP:0011038)	2.67445974
37	Hepatocellular necrosis (HP:0001404)	2.66519809
38	Abnormal biliary tract physiology (HP:0012439)	2.66039853
39	Bile duct proliferation (HP:0001408)	2.66039853
40	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.65414462
41	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.61754569
42	Methylmalonic aciduria (HP:0012120)	2.60731048
43	Polyuria (HP:0000103)	2.59869068
44	Abnormality of alanine metabolism (HP:0010916)	2.59520738
45	Hyperalaninemia (HP:0003348)	2.59520738
46	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.59520738
47	Increased muscle lipid content (HP:0009058)	2.58297042
48	Exertional dyspnea (HP:0002875)	2.56657222
49	Cerebral edema (HP:0002181)	2.55621817
50	Hyperphosphatemia (HP:0002905)	2.54544468
51	Pancytopenia (HP:0001876)	2.54502648
52	Dry hair (HP:0011359)	2.53383725
53	Abnormality of the renal cortex (HP:0011035)	2.52450226
54	Respiratory difficulties (HP:0002880)	2.51902724
55	Patent foramen ovale (HP:0001655)	2.47534791
56	Exercise intolerance (HP:0003546)	2.44628571
57	Pancreatic cysts (HP:0001737)	2.43385123
58	Enlarged kidneys (HP:0000105)	2.40314048
59	Stenosis of the external auditory canal (HP:0000402)	2.38025014
60	Reduced antithrombin III activity (HP:0001976)	2.36635373
61	Hepatic necrosis (HP:0002605)	2.34211335
62	Lethargy (HP:0001254)	2.32006063
63	Leukodystrophy (HP:0002415)	2.31543867
64	Progressive muscle weakness (HP:0003323)	2.30594309
65	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.29083386
66	Rough bone trabeculation (HP:0100670)	2.28944570
67	Aplastic anemia (HP:0001915)	2.27562987
68	Abnormality of renal excretion (HP:0011036)	2.27005536
69	Supernumerary spleens (HP:0009799)	2.24138264
70	Hyperphosphaturia (HP:0003109)	2.23186714
71	CNS demyelination (HP:0007305)	2.22197366
72	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.21711991
73	Congenital, generalized hypertrichosis (HP:0004540)	2.15308178
74	Pancreatic fibrosis (HP:0100732)	2.13868090
75	Abnormality of serine family amino acid metabolism (HP:0010894)	2.12416256
76	Abnormality of glycine metabolism (HP:0010895)	2.12416256
77	Tinnitus (HP:0000360)	2.09140050
78	Abnormal urine output (HP:0012590)	2.08297220
79	Brushfield spots (HP:0001088)	2.07716762
80	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.07586633
81	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.03883470
82	Renal tubular dysfunction (HP:0000124)	2.03209289
83	Optic disc pallor (HP:0000543)	2.02110529
84	Micronodular cirrhosis (HP:0001413)	1.96771270
85	Type I transferrin isoform profile (HP:0003642)	1.95149185
86	Respiratory failure (HP:0002878)	1.94870713
87	Hyperglycemia (HP:0003074)	1.93924132
88	Abnormality of vitamin B metabolism (HP:0004340)	1.93865153
89	Cystic liver disease (HP:0006706)	1.92926261
90	Abnormal urine phosphate concentration (HP:0012599)	1.92176413
91	Down-sloping shoulders (HP:0200021)	1.91568739
92	Hyperglycinuria (HP:0003108)	1.91224994
93	Abnormal biliary tract morphology (HP:0012440)	1.89042147
94	Split foot (HP:0001839)	1.87729541
95	Abnormal auditory evoked potentials (HP:0006958)	1.84832176
96	Albinism (HP:0001022)	1.84813534
97	Dicarboxylic aciduria (HP:0003215)	1.81629523
98	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.81629523
99	Abnormal trabecular bone morphology (HP:0100671)	1.81573153
100	Pili torti (HP:0003777)	1.80681333

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	3.75599614
2	EIF2AK1	3.23733247
3	RPS6KB2	3.15247909
4	CDC7	3.09810058
5	MST4	3.01460135
6	NME2	2.99032602
7	PDK2	2.93160730
8	VRK2	2.75637439
9	MAP3K12	2.69696410
10	PBK	2.59870676
11	CDK19	2.42479965
12	PINK1	2.37505808
13	STK16	2.33909175
14	MAPKAPK3	2.32888344
15	PIK3CA	2.28938079
16	OXSR1	2.26921309
17	TLK1	2.22487461
18	NEK1	2.21539480
19	TESK2	1.89424757
20	BCKDK	1.76314179
21	ABL2	1.73469626
22	STK39	1.56940961
23	BUB1	1.54384153
24	TESK1	1.48945890
25	PAK4	1.47870066
26	LIMK1	1.37740340
27	NME1	1.33693666
28	SCYL2	1.32860269
29	CSNK1G3	1.32082471
30	CSNK1G1	1.29881969
31	STK38	1.23852970
32	MELK	1.19070699
33	SRPK1	1.18467400
34	VRK1	1.14586070
35	DYRK3	1.12657734
36	MAP3K13	1.09643572
37	TRIM28	1.07676092
38	CSNK1A1L	1.04261306
39	MYLK	1.02179344
40	BMPR1B	1.00533026
41	STK4	1.00268134
42	TAOK3	0.97306235
43	CSNK1G2	0.95066164
44	PLK1	0.94986425
45	WEE1	0.90594369
46	RPS6KA5	0.89241580
47	WNK4	0.87674526
48	GRK1	0.82104213
49	PRKCI	0.78775708
50	LMTK2	0.75054195
51	ADRBK2	0.74586322
52	PASK	0.73033206
53	FGR	0.66789891
54	CDK8	0.64726085
55	AURKA	0.64430025
56	PHKG1	0.64167712
57	PHKG2	0.64167712
58	NUAK1	0.62975581
59	TGFBR1	0.62436229
60	BRSK2	0.60900029
61	AURKB	0.60616122
62	CAMK2D	0.60530452
63	ERBB4	0.60324230
64	FRK	0.59036475
65	MAP2K2	0.58288668
66	ILK	0.57817638
67	MAP3K8	0.57807282
68	CAMK2G	0.56556794
69	MAP3K7	0.56092877
70	CDK9	0.55574899
71	ZAK	0.53076559
72	CSNK1A1	0.52495335
73	BRSK1	0.52028938
74	DAPK3	0.51651758
75	PLK4	0.51068471
76	DAPK1	0.50371568
77	MST1R	0.49999472
78	JAK3	0.49489067
79	PLK3	0.49384350
80	PAK1	0.47279897
81	CSNK2A1	0.43416682
82	TNIK	0.43394415
83	AKT2	0.43315702
84	TTK	0.43232119
85	PRKCE	0.42603903
86	CAMK2B	0.41897255
87	CDK7	0.41835310
88	KDR	0.40522204
89	IKBKB	0.39847595
90	PIM2	0.39027995
91	CASK	0.36433866
92	CHEK2	0.36291616
93	CSNK2A2	0.35382851
94	RPS6KA4	0.31957339
95	PRKCD	0.31805829
96	MKNK2	0.29470782
97	ADRBK1	0.29420675
98	TSSK6	0.28988079
99	CLK1	0.27447448
100	MAP4K2	0.26646286

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.80171441
2	Proteasome_Homo sapiens_hsa03050	3.85238663
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.46796439
4	Parkinsons disease_Homo sapiens_hsa05012	2.55572785
5	RNA polymerase_Homo sapiens_hsa03020	2.43524331
6	DNA replication_Homo sapiens_hsa03030	2.27428056
7	Fatty acid elongation_Homo sapiens_hsa00062	2.25038875
8	Glutathione metabolism_Homo sapiens_hsa00480	2.03342388
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.02494287
10	Base excision repair_Homo sapiens_hsa03410	1.95621529
11	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.92064164
12	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.88313593
13	Protein export_Homo sapiens_hsa03060	1.86814328
14	Collecting duct acid secretion_Homo sapiens_hsa04966	1.84662136
15	Huntingtons disease_Homo sapiens_hsa05016	1.77515206
16	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.75267024
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.72467571
18	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.72249339
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.68708364
20	One carbon pool by folate_Homo sapiens_hsa00670	1.67161472
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.63083451
22	Folate biosynthesis_Homo sapiens_hsa00790	1.55578032
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.55388531
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.54091161
25	Sulfur relay system_Homo sapiens_hsa04122	1.53784122
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.48686124
27	Alzheimers disease_Homo sapiens_hsa05010	1.46069037
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45900973
29	Mismatch repair_Homo sapiens_hsa03430	1.44823065
30	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.42960403
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.42548037
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.40656175
33	Homologous recombination_Homo sapiens_hsa03440	1.35450529
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34405042
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.32665090
36	Peroxisome_Homo sapiens_hsa04146	1.29697615
37	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.29514914
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.27503927
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.27040989
40	Vibrio cholerae infection_Homo sapiens_hsa05110	1.26297068
41	Galactose metabolism_Homo sapiens_hsa00052	1.22706938
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.22471579
43	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.20232093
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.19270546
45	RNA transport_Homo sapiens_hsa03013	1.19106176
46	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.18761139
47	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.18294404
48	RNA degradation_Homo sapiens_hsa03018	1.18245316
49	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.14970095
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.12495353
51	Cardiac muscle contraction_Homo sapiens_hsa04260	1.07759280
52	Spliceosome_Homo sapiens_hsa03040	1.07586718
53	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.01994123
54	Retinol metabolism_Homo sapiens_hsa00830	0.98901270
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.98652782
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97878804
57	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.95783620
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92931358
59	Histidine metabolism_Homo sapiens_hsa00340	0.88679118
60	Metabolic pathways_Homo sapiens_hsa01100	0.87605377
61	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.86308995
62	Propanoate metabolism_Homo sapiens_hsa00640	0.85368952
63	Purine metabolism_Homo sapiens_hsa00230	0.83270923
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.74388530
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73536668
66	Basal transcription factors_Homo sapiens_hsa03022	0.73209225
67	Caffeine metabolism_Homo sapiens_hsa00232	0.70801634
68	Selenocompound metabolism_Homo sapiens_hsa00450	0.69058767
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.68052352
70	Carbon metabolism_Homo sapiens_hsa01200	0.67726330
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67584458
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65591126
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.64887934
74	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.64547687
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.64511683
76	Sulfur metabolism_Homo sapiens_hsa00920	0.64400385
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.53707513
78	Tryptophan metabolism_Homo sapiens_hsa00380	0.53000022
79	Non-homologous end-joining_Homo sapiens_hsa03450	0.51981348
80	Tight junction_Homo sapiens_hsa04530	0.51696117
81	Pentose phosphate pathway_Homo sapiens_hsa00030	0.49382430
82	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.45644071
83	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.42035319
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41274051
85	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.39270889
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.38194187
87	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.35701687
88	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.34790294
89	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33541265
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.31638548
91	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.31540226
92	Protein digestion and absorption_Homo sapiens_hsa04974	0.31171997
93	Ether lipid metabolism_Homo sapiens_hsa00565	0.29134531
94	Lysosome_Homo sapiens_hsa04142	0.24318045
95	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.24143675
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.24040649
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.22709227
98	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.21803548
99	p53 signaling pathway_Homo sapiens_hsa04115	0.21338892
100	Cell cycle_Homo sapiens_hsa04110	0.19284896

KRT18P65

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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