ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	8.58089177
2	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	8.58089177
3	homocysteine metabolic process (GO:0050667)	8.14199889
4	folic acid-containing compound biosynthetic process (GO:0009396)	7.64630983
5	regulation of plasminogen activation (GO:0010755)	7.25250354
6	sulfur amino acid catabolic process (GO:0000098)	7.16172231
7	cysteine metabolic process (GO:0006534)	6.85941940
8	mitochondrial RNA metabolic process (GO:0000959)	6.76427017
9	adenosine metabolic process (GO:0046085)	6.61432877
10	purine nucleotide salvage (GO:0032261)	6.56502514
11	white fat cell differentiation (GO:0050872)	6.35896165
12	desmosome organization (GO:0002934)	6.08949140
13	pteridine-containing compound biosynthetic process (GO:0042559)	5.64255054
14	gonadal mesoderm development (GO:0007506)	5.61992204
15	galactose catabolic process (GO:0019388)	5.59273534
16	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	5.44968205
17	hepatocyte apoptotic process (GO:0097284)	5.21406337
18	L-serine metabolic process (GO:0006563)	5.17025071
19	negative regulation of DNA biosynthetic process (GO:2000279)	5.09088679
20	nucleoside transmembrane transport (GO:1901642)	5.07236753
21	IMP biosynthetic process (GO:0006188)	4.99633662
22	protein-cofactor linkage (GO:0018065)	4.97845754
23	inner ear receptor cell development (GO:0060119)	4.88958593
24	galactose metabolic process (GO:0006012)	4.81366092
25	microtubule nucleation (GO:0007020)	4.74028032
26	aminoglycoside antibiotic metabolic process (GO:0030647)	4.54408811
27	rRNA methylation (GO:0031167)	4.41585199
28	serine family amino acid biosynthetic process (GO:0009070)	4.27359245
29	negative regulation of keratinocyte proliferation (GO:0010839)	4.23291541
30	alternative mRNA splicing, via spliceosome (GO:0000380)	4.17478397
31	primary amino compound metabolic process (GO:1901160)	4.05508791
32	histone H4-K12 acetylation (GO:0043983)	4.05376560
33	positive regulation of endothelial cell differentiation (GO:0045603)	4.02930542
34	IMP metabolic process (GO:0046040)	4.02823940
35	nucleotide salvage (GO:0043173)	4.01611015
36	rRNA modification (GO:0000154)	4.00800460
37	tetrahydrofolate metabolic process (GO:0046653)	3.89139401
38	folic acid-containing compound metabolic process (GO:0006760)	3.88013208
39	cochlea development (GO:0090102)	3.84727597
40	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	3.81374929
41	tRNA modification (GO:0006400)	3.71358082
42	proteasome assembly (GO:0043248)	3.71083397
43	CENP-A containing nucleosome assembly (GO:0034080)	3.68984144
44	regulation of gonadotropin secretion (GO:0032276)	3.68912719
45	negative regulation of Ras GTPase activity (GO:0034261)	3.67446364
46	nucleoside transport (GO:0015858)	3.60853362
47	transcription from mitochondrial promoter (GO:0006390)	3.60122644
48	folic acid transport (GO:0015884)	3.56931806
49	sulfur amino acid biosynthetic process (GO:0000097)	3.54053744
50	regulation of tight junction assembly (GO:2000810)	3.50887617
51	negative regulation of telomerase activity (GO:0051974)	3.50071271
52	regulation of sequestering of triglyceride (GO:0010889)	3.49765427
53	pseudouridine synthesis (GO:0001522)	3.49287827
54	regulation of vitamin D biosynthetic process (GO:0060556)	3.48493370
55	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.45480121
56	ATP hydrolysis coupled proton transport (GO:0015991)	3.45480121
57	tRNA processing (GO:0008033)	3.44471111
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.42190885
59	NADH dehydrogenase complex assembly (GO:0010257)	3.42190885
60	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.42190885
61	pteridine-containing compound metabolic process (GO:0042558)	3.42164337
62	polyamine biosynthetic process (GO:0006596)	3.41086481
63	ribosome biogenesis (GO:0042254)	3.38189915
64	chromatin remodeling at centromere (GO:0031055)	3.38046299
65	placenta development (GO:0001890)	3.37984808
66	glycoside metabolic process (GO:0016137)	3.35238079
67	phosphatidylglycerol biosynthetic process (GO:0006655)	3.34939815
68	protein-chromophore linkage (GO:0018298)	3.30190815
69	neutrophil activation involved in immune response (GO:0002283)	3.30151731
70	acrosome assembly (GO:0001675)	3.30017252
71	polyamine metabolic process (GO:0006595)	3.27596508
72	regulation of vitamin metabolic process (GO:0030656)	3.24482942
73	cell migration involved in heart development (GO:0060973)	3.22549679
74	cartilage morphogenesis (GO:0060536)	3.17535341
75	GMP metabolic process (GO:0046037)	3.16576204
76	guanosine-containing compound biosynthetic process (GO:1901070)	3.13648519
77	purine-containing compound salvage (GO:0043101)	3.11297408
78	innervation (GO:0060384)	3.11005681
79	regulation of cellular respiration (GO:0043457)	3.10822187
80	heme transport (GO:0015886)	3.10529345
81	regulation of endothelial cell differentiation (GO:0045601)	3.09878645
82	negative regulation of catenin import into nucleus (GO:0035414)	3.06194873
83	organic cation transport (GO:0015695)	3.04150232
84	COPII vesicle coating (GO:0048208)	3.03026313
85	sulfur amino acid metabolic process (GO:0000096)	3.02499553
86	serine family amino acid catabolic process (GO:0009071)	3.01769400
87	behavioral fear response (GO:0001662)	3.00990954
88	behavioral defense response (GO:0002209)	3.00990954
89	preassembly of GPI anchor in ER membrane (GO:0016254)	3.00018093
90	response to vitamin A (GO:0033189)	2.99037641
91	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.98145966
92	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.97272874
93	one-carbon metabolic process (GO:0006730)	2.94029532
94	DNA replication-independent nucleosome organization (GO:0034724)	2.93472958
95	DNA replication-independent nucleosome assembly (GO:0006336)	2.93472958
96	GTP biosynthetic process (GO:0006183)	2.91389784
97	artery smooth muscle contraction (GO:0014824)	2.91178456
98	vitamin transmembrane transport (GO:0035461)	2.90992377
99	histone exchange (GO:0043486)	2.90510384
100	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.89697181

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.98378419
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.88453003
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.60027565
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.58454959
5	E2F7_22180533_ChIP-Seq_HELA_Human	3.36710132
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.02403463
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.77771913
8	VDR_22108803_ChIP-Seq_LS180_Human	2.43472588
9	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.34206216
10	ZNF263_19887448_ChIP-Seq_K562_Human	2.32566965
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.26531903
12	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.25080590
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.17221800
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.10608946
15	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.09605361
16	AR_21909140_ChIP-Seq_LNCAP_Human	2.07363813
17	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.04221463
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	10.0127870
19	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.99928368
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.98911089
21	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.95129382
22	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.93163846
23	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.84533033
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.82651386
25	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.78909232
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.74060672
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.67510947
28	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.67481522
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.66437132
30	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.64565849
31	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.54981126
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.49052226
33	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.48986598
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.44523633
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.41960673
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.35005427
37	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.33495822
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.33139711
39	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.32513735
40	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.31578077
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.28802139
42	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.26106869
43	STAT1_20625510_ChIP-Seq_HELA_Human	1.25259054
44	CDX2_22108803_ChIP-Seq_LS180_Human	1.24747478
45	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.24249815
46	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.19115623
47	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.17368425
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.15717767
49	NCOR_22424771_ChIP-Seq_293T_Human	1.14549535
50	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.13203375
51	GATA4_25053715_ChIP-Seq_YYC3_Human	1.12100625
52	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.11542728
53	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.08576985
54	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07262575
55	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.06643450
56	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.06099820
57	ERG_20517297_ChIP-Seq_VCAP_Human	1.05866720
58	XRN2_22483619_ChIP-Seq_HELA_Human	1.04694084
59	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.04297794
60	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03729002
61	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.03578639
62	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.01694809
63	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.01550680
64	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.99863793
65	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.98636072
66	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.97094744
67	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97008193
68	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.96178978
69	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.94956601
70	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.94578021
71	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.93991270
72	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.92599236
73	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92490053
74	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.92080928
75	DCP1A_22483619_ChIP-Seq_HELA_Human	0.91555093
76	KDM5A_27292631_Chip-Seq_BREAST_Human	0.91518321
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89857689
78	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.89757789
79	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.89309366
80	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.88026643
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.87798921
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.87798921
83	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.87388404
84	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.87365794
85	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.87265013
86	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.86566148
87	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.84976464
88	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84749522
89	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.81344204
90	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.81223457
91	P300_27268052_Chip-Seq_Bcells_Human	0.80191178
92	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.79634468
93	AR_20517297_ChIP-Seq_VCAP_Human	0.79388024
94	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.79134969
95	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.78035988
96	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.76500604
97	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.76455237
98	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.76353909
99	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.74935907
100	SOX2_20726797_ChIP-Seq_SW620_Human	0.74249065

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	5.43801040
2	MP0003806_abnormal_nucleotide_metabolis	5.28749869
3	MP0005360_urolithiasis	4.86215976
4	MP0005367_renal/urinary_system_phenotyp	4.16385415
5	MP0000516_abnormal_urinary_system	4.16385415
6	MP0008995_early_reproductive_senescence	3.92515749
7	MP0005646_abnormal_pituitary_gland	3.66836783
8	MP0004147_increased_porphyrin_level	3.38965343
9	MP0003705_abnormal_hypodermis_morpholog	3.33376137
10	MP0001661_extended_life_span	3.24294160
11	MP0003183_abnormal_peptide_metabolism	3.19171907
12	MP0000013_abnormal_adipose_tissue	3.15667488
13	MP0002396_abnormal_hematopoietic_system	3.13100988
14	MP0002938_white_spotting	2.70178230
15	MP0002736_abnormal_nociception_after	2.56033177
16	MP0005332_abnormal_amino_acid	2.33365490
17	MP0008872_abnormal_physiological_respon	2.07646540
18	MP0004885_abnormal_endolymph	1.98826999
19	MP0005085_abnormal_gallbladder_physiolo	1.75834914
20	MP0003252_abnormal_bile_duct	1.70937138
21	MP0003186_abnormal_redox_activity	1.70546463
22	MP0003786_premature_aging	1.70079874
23	MP0000647_abnormal_sebaceous_gland	1.69297220
24	MP0001764_abnormal_homeostasis	1.69080996
25	MP0001968_abnormal_touch/_nociception	1.56542711
26	MP0009697_abnormal_copulation	1.54086813
27	MP0003693_abnormal_embryo_hatching	1.53150787
28	MP0005377_hearing/vestibular/ear_phenot	1.52342334
29	MP0003878_abnormal_ear_physiology	1.52342334
30	MP0004019_abnormal_vitamin_homeostasis	1.50102878
31	MP0002160_abnormal_reproductive_system	1.48885473
32	MP0003724_increased_susceptibility_to	1.42520052
33	MP0001756_abnormal_urination	1.42014857
34	MP0004130_abnormal_muscle_cell	1.32037061
35	MP0002095_abnormal_skin_pigmentation	1.26759405
36	MP0000003_abnormal_adipose_tissue	1.24184114
37	MP0008875_abnormal_xenobiotic_pharmacok	1.23924556
38	MP0002837_dystrophic_cardiac_calcinosis	1.23485380
39	MP0008877_abnormal_DNA_methylation	1.21926302
40	MP0000534_abnormal_ureter_morphology	1.19199761
41	MP0005551_abnormal_eye_electrophysiolog	1.15906619
42	MP0005595_abnormal_vascular_smooth	1.14577089
43	MP0005376_homeostasis/metabolism_phenot	1.13308691
44	MP0004185_abnormal_adipocyte_glucose	1.11953516
45	MP0009643_abnormal_urine_homeostasis	1.07143376
46	MP0005636_abnormal_mineral_homeostasis	1.05363042
47	MP0005164_abnormal_response_to	1.03716096
48	MP0005075_abnormal_melanosome_morpholog	1.03344778
49	MP0005410_abnormal_fertilization	1.01411673
50	MP0005319_abnormal_enzyme/_coenzyme	0.91775736
51	MP0002735_abnormal_chemical_nociception	0.89614910
52	MP0005365_abnormal_bile_salt	0.87426498
53	MP0004233_abnormal_muscle_weight	0.85894145
54	MP0001666_abnormal_nutrient_absorption	0.85523966
55	MP0002139_abnormal_hepatobiliary_system	0.84509875
56	MP0002138_abnormal_hepatobiliary_system	0.82618975
57	MP0005389_reproductive_system_phenotype	0.81580927
58	MP0003942_abnormal_urinary_system	0.81260702
59	MP0009764_decreased_sensitivity_to	0.80259375
60	MP0005266_abnormal_metabolism	0.77097201
61	MP0000026_abnormal_inner_ear	0.76989566
62	MP0003195_calcinosis	0.76370003
63	MP0005253_abnormal_eye_physiology	0.75965496
64	MP0003111_abnormal_nucleus_morphology	0.75843049
65	MP0004957_abnormal_blastocyst_morpholog	0.75275688
66	MP0001944_abnormal_pancreas_morphology	0.73684900
67	MP0001919_abnormal_reproductive_system	0.71640194
68	MP0003638_abnormal_response/metabolism_	0.70698871
69	MP0000631_abnormal_neuroendocrine_gland	0.70682769
70	MP0000230_abnormal_systemic_arterial	0.70383300
71	MP0000371_diluted_coat_color	0.69247242
72	MP0001963_abnormal_hearing_physiology	0.68619566
73	MP0002210_abnormal_sex_determination	0.64727767
74	MP0001145_abnormal_male_reproductive	0.64191395
75	MP0000653_abnormal_sex_gland	0.62308696
76	MP0002069_abnormal_eating/drinking_beha	0.61016214
77	MP0005584_abnormal_enzyme/coenzyme_acti	0.59185621
78	MP0009765_abnormal_xenobiotic_induced	0.57932166
79	MP0003718_maternal_effect	0.56087514
80	MP0010094_abnormal_chromosome_stability	0.55100158
81	MP0000747_muscle_weakness	0.54601861
82	MP0000372_irregular_coat_pigmentation	0.54439819
83	MP0000538_abnormal_urinary_bladder	0.53784681
84	MP0001485_abnormal_pinna_reflex	0.52526844
85	MP0008873_increased_physiological_sensi	0.52357936
86	MP0004043_abnormal_pH_regulation	0.51491436
87	MP0003077_abnormal_cell_cycle	0.50741316
88	MP0002078_abnormal_glucose_homeostasis	0.49807273
89	MP0003936_abnormal_reproductive_system	0.49170681
90	MP0006036_abnormal_mitochondrial_physio	0.48940677
91	MP0001270_distended_abdomen	0.48787740
92	MP0001765_abnormal_ion_homeostasis	0.48171013
93	MP0009379_abnormal_foot_pigmentation	0.47164622
94	MP0000762_abnormal_tongue_morphology	0.47143462
95	MP0001929_abnormal_gametogenesis	0.46895801
96	MP0003953_abnormal_hormone_level	0.46753382
97	MP0000598_abnormal_liver_morphology	0.46086266
98	MP0003698_abnormal_male_reproductive	0.45906796
99	MP0000383_abnormal_hair_follicle	0.44875959
100	MP0001486_abnormal_startle_reflex	0.44253689

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	9.97235298
2	Hyperalaninemia (HP:0003348)	9.97235298
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	9.97235298
4	Constricted visual fields (HP:0001133)	5.36896458
5	Esophageal varix (HP:0002040)	4.91254913
6	Congenital sensorineural hearing impairment (HP:0008527)	4.45276092
7	Birth length less than 3rd percentile (HP:0003561)	4.36418983
8	Abnormal umbilical cord blood vessels (HP:0011403)	4.09947804
9	Single umbilical artery (HP:0001195)	4.09947804
10	Abnormality of the fetal cardiovascular system (HP:0010948)	4.09947804
11	Abnormality of serum amino acid levels (HP:0003112)	4.01415842
12	White forelock (HP:0002211)	3.99412992
13	Patchy hypopigmentation of hair (HP:0011365)	3.97384653
14	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.90802800
15	Homocystinuria (HP:0002156)	3.78035436
16	Abnormality of homocysteine metabolism (HP:0010919)	3.78035436
17	Conjugated hyperbilirubinemia (HP:0002908)	3.56787481
18	Spontaneous hematomas (HP:0007420)	3.39180727
19	Myocardial infarction (HP:0001658)	3.33716615
20	Attenuation of retinal blood vessels (HP:0007843)	3.31181347
21	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.26265138
22	Anorexia (HP:0002039)	3.20142165
23	Poor speech (HP:0002465)	3.07974022
24	Congenital, generalized hypertrichosis (HP:0004540)	3.05673781
25	Generalized aminoaciduria (HP:0002909)	3.05133880
26	Abnormality of the umbilical cord (HP:0010881)	2.79829263
27	Conjunctival telangiectasia (HP:0000524)	2.79042533
28	Chorioretinal atrophy (HP:0000533)	2.74224008
29	Nausea (HP:0002018)	2.68303834
30	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.65292301
31	Micronodular cirrhosis (HP:0001413)	2.61724635
32	Cone-rod dystrophy (HP:0000548)	2.59097500
33	Toxemia of pregnancy (HP:0100603)	2.55925093
34	Large for gestational age (HP:0001520)	2.54299054
35	Increased serum pyruvate (HP:0003542)	2.52242582
36	Hypoalphalipoproteinemia (HP:0003233)	2.51994327
37	Cavernous hemangioma (HP:0001048)	2.51898948
38	Heterochromia iridis (HP:0001100)	2.43382523
39	Action tremor (HP:0002345)	2.37544745
40	Duplicated collecting system (HP:0000081)	2.36560183
41	Pigmentary retinal degeneration (HP:0001146)	2.33567376
42	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.31736148
43	Lactic acidosis (HP:0003128)	2.27605977
44	Hypomagnesemia (HP:0002917)	2.27280303
45	Tetany (HP:0001281)	2.26557381
46	Conjunctival hamartoma (HP:0100780)	2.25208760
47	Increased serum lactate (HP:0002151)	2.23026590
48	Abnormality of the renal collecting system (HP:0004742)	2.22101291
49	Hepatocellular carcinoma (HP:0001402)	2.21530817
50	Megaloblastic anemia (HP:0001889)	2.20200714
51	Neuroendocrine neoplasm (HP:0100634)	2.17993097
52	Oligomenorrhea (HP:0000876)	2.15934117
53	Proximal tubulopathy (HP:0000114)	2.15612733
54	Maternal diabetes (HP:0009800)	2.14169259
55	Visceral angiomatosis (HP:0100761)	2.12988373
56	Biconcave vertebral bodies (HP:0004586)	2.11813450
57	Cortical visual impairment (HP:0100704)	2.09582797
58	Pendular nystagmus (HP:0012043)	2.09074928
59	Abnormality of glycolysis (HP:0004366)	2.08902118
60	Ileus (HP:0002595)	2.05832738
61	Abnormality of pyrimidine metabolism (HP:0004353)	2.01349522
62	Reticulocytopenia (HP:0001896)	2.01002716
63	Focal segmental glomerulosclerosis (HP:0000097)	1.99818124
64	Abnormality of magnesium homeostasis (HP:0004921)	1.98160125
65	Reduced subcutaneous adipose tissue (HP:0003758)	1.97829402
66	Pulmonary embolism (HP:0002204)	1.97338036
67	Hemangiomatosis (HP:0007461)	1.96467462
68	Acute necrotizing encephalopathy (HP:0006965)	1.94438178
69	Acute encephalopathy (HP:0006846)	1.92997132
70	Abnormality of methionine metabolism (HP:0010901)	1.92760432
71	Metabolic acidosis (HP:0001942)	1.92574806
72	Mitochondrial inheritance (HP:0001427)	1.91501654
73	Increased CSF lactate (HP:0002490)	1.90195275
74	Intrahepatic cholestasis (HP:0001406)	1.90127468
75	Hepatocellular necrosis (HP:0001404)	1.87448632
76	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.85271085
77	Abnormalities of placenta or umbilical cord (HP:0001194)	1.84867856
78	Decreased subcutaneous fat (HP:0001002)	1.84622597
79	Hypoplastic left heart (HP:0004383)	1.84343185
80	Myopathic facies (HP:0002058)	1.84019564
81	Abnormality of urine glucose concentration (HP:0011016)	1.80688342
82	Glycosuria (HP:0003076)	1.80688342
83	Petechiae (HP:0000967)	1.80572706
84	Hyperglycinemia (HP:0002154)	1.79311200
85	Hyperphosphaturia (HP:0003109)	1.79271313
86	Pancreatitis (HP:0001733)	1.78370453
87	Hepatic necrosis (HP:0002605)	1.76350682
88	Dyskinesia (HP:0100660)	1.74024582
89	Increased corneal curvature (HP:0100692)	1.73539880
90	Keratoconus (HP:0000563)	1.73539880
91	Hypopigmentation of the fundus (HP:0007894)	1.73404382
92	Esophageal neoplasm (HP:0100751)	1.71605631
93	Neoplasm of head and neck (HP:0012288)	1.71605631
94	Abnormal mitochondria in muscle tissue (HP:0008316)	1.70943773
95	Arteriovenous malformation (HP:0100026)	1.70890725
96	Stenosis of the external auditory canal (HP:0000402)	1.70411489
97	Progressive macrocephaly (HP:0004481)	1.70143689
98	Broad metatarsal (HP:0001783)	1.68796361
99	Brittle hair (HP:0002299)	1.67982725
100	Hyperglycemia (HP:0003074)	1.64724588

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	4.75250910
2	MAP3K3	4.34367108
3	RPS6KB2	3.82682983
4	MAP2K3	3.38891085
5	ZAK	3.23857518
6	STK39	2.75212956
7	CDK9	2.59834434
8	JAK3	2.50494001
9	OXSR1	2.49267907
10	FGR	2.42568569
11	VRK2	2.41362674
12	EPHA2	2.34835068
13	PBK	2.18202914
14	IRAK4	2.11113828
15	PAK4	1.85934214
16	NTRK2	1.71351645
17	MST4	1.53066978
18	FRK	1.50269447
19	EIF2AK3	1.50028278
20	MAP3K11	1.47639111
21	ADRBK1	1.39286997
22	EPHB2	1.37050453
23	CCNB1	1.36326217
24	PDK2	1.34412972
25	BUB1	1.28355858
26	INSRR	1.27703084
27	MAP3K12	1.27417380
28	CDK19	1.20760762
29	MAP2K1	1.20564928
30	NEK6	1.16337764
31	NME2	1.16148595
32	ADRBK2	1.14566780
33	SGK494	1.03708317
34	SGK223	1.03708317
35	PRKCI	0.98175389
36	CAMK2G	0.94055343
37	PLK4	0.92973198
38	PIM2	0.92164350
39	CSNK1A1	0.91207783
40	LMTK2	0.90743970
41	NUAK1	0.89717947
42	VRK1	0.88732599
43	TIE1	0.88437742
44	STK16	0.87043915
45	CHEK2	0.85542387
46	STK10	0.83514936
47	WNK4	0.83356940
48	TSSK6	0.83198491
49	CAMK2D	0.82208761
50	GRK1	0.81578324
51	AURKA	0.81041278
52	MST1R	0.81002646
53	PLK3	0.80727866
54	NEK1	0.80490965
55	MAP4K1	0.76856788
56	PHKG1	0.76322301
57	PHKG2	0.76322301
58	EIF2AK1	0.75262646
59	PLK1	0.75257842
60	CAMK2B	0.72921540
61	TTK	0.71359097
62	TAF1	0.70812248
63	CAMK1	0.69444383
64	SGK2	0.69220137
65	MYLK	0.68932464
66	ABL2	0.67919225
67	PRKCE	0.67216487
68	BCKDK	0.66140947
69	MET	0.65889141
70	AKT2	0.63170271
71	NTRK3	0.62493151
72	PASK	0.60971468
73	CDK7	0.60598148
74	PTK6	0.59315592
75	DYRK2	0.58466160
76	PIK3CA	0.50835237
77	DAPK3	0.49547477
78	PRKCD	0.47522121
79	ILK	0.47184495
80	CSNK1G3	0.46391328
81	RPS6KA5	0.44333445
82	MAP2K2	0.44083554
83	IKBKB	0.43610870
84	PRKCA	0.43368995
85	EGFR	0.43109378
86	PINK1	0.42761502
87	AURKB	0.39566720
88	ATR	0.38068652
89	WEE1	0.37847248
90	EIF2AK2	0.36772678
91	MAP4K2	0.36577333
92	CSNK1G1	0.36558180
93	CSNK1G2	0.36471737
94	BMPR1B	0.36287150
95	CAMKK2	0.35912298
96	CAMK2A	0.34460147
97	MAP3K8	0.33728752
98	UHMK1	0.33316479
99	CSNK1A1L	0.32799799
100	CSNK2A1	0.32358017

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	3.76993055
2	Collecting duct acid secretion_Homo sapiens_hsa04966	3.76451677
3	Sulfur metabolism_Homo sapiens_hsa00920	3.68986141
4	Selenocompound metabolism_Homo sapiens_hsa00450	3.15919262
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.98311218
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.78710506
7	Sulfur relay system_Homo sapiens_hsa04122	2.75217037
8	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.73567015
9	Proteasome_Homo sapiens_hsa03050	2.72700833
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.29553929
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.08315395
12	Homologous recombination_Homo sapiens_hsa03440	2.00558357
13	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.99308212
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86343339
15	Vibrio cholerae infection_Homo sapiens_hsa05110	1.85356569
16	Ribosome_Homo sapiens_hsa03010	1.80161643
17	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.76242393
18	Galactose metabolism_Homo sapiens_hsa00052	1.73216746
19	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.67487242
20	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.64719877
21	Parkinsons disease_Homo sapiens_hsa05012	1.61756930
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.49468491
23	Morphine addiction_Homo sapiens_hsa05032	1.44137911
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.36638697
25	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.31326391
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.26319997
27	RNA degradation_Homo sapiens_hsa03018	1.25754748
28	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.24956911
29	GABAergic synapse_Homo sapiens_hsa04727	1.23482401
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.18675426
31	Fat digestion and absorption_Homo sapiens_hsa04975	1.17193539
32	Huntingtons disease_Homo sapiens_hsa05016	1.15310617
33	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.14801603
34	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.14346795
35	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.12461051
36	Alzheimers disease_Homo sapiens_hsa05010	1.09356285
37	Folate biosynthesis_Homo sapiens_hsa00790	1.07050671
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06602250
39	Nicotine addiction_Homo sapiens_hsa05033	1.05838209
40	DNA replication_Homo sapiens_hsa03030	1.05794568
41	RNA transport_Homo sapiens_hsa03013	1.01619182
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.01480906
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.98517157
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95156873
45	Spliceosome_Homo sapiens_hsa03040	0.93904256
46	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.90411408
47	Retinol metabolism_Homo sapiens_hsa00830	0.89959467
48	Rheumatoid arthritis_Homo sapiens_hsa05323	0.87832979
49	Regulation of autophagy_Homo sapiens_hsa04140	0.87494491
50	Peroxisome_Homo sapiens_hsa04146	0.86017674
51	Metabolic pathways_Homo sapiens_hsa01100	0.85529839
52	Arginine and proline metabolism_Homo sapiens_hsa00330	0.84966079
53	Purine metabolism_Homo sapiens_hsa00230	0.81085775
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80862147
55	ABC transporters_Homo sapiens_hsa02010	0.77536994
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77285792
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.76535386
58	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.75306433
59	Linoleic acid metabolism_Homo sapiens_hsa00591	0.75091389
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.75075045
61	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.73971331
62	Basal transcription factors_Homo sapiens_hsa03022	0.71927427
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71560668
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.68682902
65	Base excision repair_Homo sapiens_hsa03410	0.67440336
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65907067
67	Carbon metabolism_Homo sapiens_hsa01200	0.64552375
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64353909
69	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.64260512
70	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.62891185
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.61898099
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60809570
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60796533
74	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.60547888
75	Other glycan degradation_Homo sapiens_hsa00511	0.60250330
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.59840655
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58323592
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.58300159
79	Glutathione metabolism_Homo sapiens_hsa00480	0.57887751
80	Taste transduction_Homo sapiens_hsa04742	0.55932594
81	RNA polymerase_Homo sapiens_hsa03020	0.55397879
82	Protein export_Homo sapiens_hsa03060	0.54509084
83	Butanoate metabolism_Homo sapiens_hsa00650	0.52786601
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52531229
85	Phenylalanine metabolism_Homo sapiens_hsa00360	0.52237536
86	Pancreatic secretion_Homo sapiens_hsa04972	0.52127588
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.44984752
88	Serotonergic synapse_Homo sapiens_hsa04726	0.43422022
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42920680
90	Fanconi anemia pathway_Homo sapiens_hsa03460	0.41580754
91	Alcoholism_Homo sapiens_hsa05034	0.40931072
92	Mismatch repair_Homo sapiens_hsa03430	0.39837856
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.38822485
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.38363056
95	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.36833408
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36716823
97	Olfactory transduction_Homo sapiens_hsa04740	0.34429260
98	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34311550
99	Fatty acid elongation_Homo sapiens_hsa00062	0.34126066
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.33999482

KRT18P68

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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