KRT18P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA modification (GO:0000154)6.45992468
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.17805029
3tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.17805029
4rRNA methylation (GO:0031167)5.98420813
5inner mitochondrial membrane organization (GO:0007007)5.31737845
6cysteine metabolic process (GO:0006534)4.68490336
7preassembly of GPI anchor in ER membrane (GO:0016254)4.52637006
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.43463181
9regulation of mitotic spindle checkpoint (GO:1903504)4.43463181
10adenosine metabolic process (GO:0046085)4.29708562
11positive regulation of mitochondrial fission (GO:0090141)4.25772924
12histone H2A acetylation (GO:0043968)4.09703383
13histone H4-K12 acetylation (GO:0043983)4.03396804
14homocysteine metabolic process (GO:0050667)3.97050189
15microtubule nucleation (GO:0007020)3.85566356
16phosphorylated carbohydrate dephosphorylation (GO:0046838)3.66822624
17inositol phosphate dephosphorylation (GO:0046855)3.66822624
18energy homeostasis (GO:0097009)3.65124281
19adult feeding behavior (GO:0008343)3.61882721
20pyrimidine dimer repair (GO:0006290)3.61825980
21folic acid-containing compound biosynthetic process (GO:0009396)3.59062752
22tRNA modification (GO:0006400)3.52609574
23positive regulation of endothelial cell differentiation (GO:0045603)3.48361647
24purine nucleotide salvage (GO:0032261)3.47559598
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.40408145
26NADH dehydrogenase complex assembly (GO:0010257)3.40408145
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40408145
28inositol phosphate catabolic process (GO:0071545)3.39304105
29negative regulation of cAMP-mediated signaling (GO:0043951)3.34105409
30negative regulation of epidermal cell differentiation (GO:0045605)3.33038375
31CENP-A containing nucleosome assembly (GO:0034080)3.31254831
32epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.25969376
33sulfur amino acid biosynthetic process (GO:0000097)3.23619987
34response to muramyl dipeptide (GO:0032495)3.23517819
35positive regulation of developmental pigmentation (GO:0048087)3.20695728
36chromatin remodeling at centromere (GO:0031055)3.20155662
37negative regulation of telomere maintenance (GO:0032205)3.19545474
38sulfur amino acid catabolic process (GO:0000098)3.19287593
39alternative mRNA splicing, via spliceosome (GO:0000380)3.18705590
40positive regulation of glycolytic process (GO:0045821)3.10513517
41negative regulation of cell cycle arrest (GO:0071157)3.08753406
42negative regulation of cell killing (GO:0031342)3.08731530
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08731530
44GPI anchor biosynthetic process (GO:0006506)3.07368723
45negative regulation of interleukin-10 production (GO:0032693)3.07193011
46protein-cofactor linkage (GO:0018065)3.05823644
47GPI anchor metabolic process (GO:0006505)3.04283809
48protein K48-linked deubiquitination (GO:0071108)3.02938516
49leukotriene biosynthetic process (GO:0019370)3.02277911
50pseudouridine synthesis (GO:0001522)2.98628477
51pyrimidine nucleobase catabolic process (GO:0006208)2.98520879
52aminoglycoside antibiotic metabolic process (GO:0030647)2.98159285
53peroxisome fission (GO:0016559)2.95066145
54negative regulation of Notch signaling pathway (GO:0045746)2.93887695
55cellular response to glucose starvation (GO:0042149)2.91894442
56histone exchange (GO:0043486)2.91432617
57DNA replication-dependent nucleosome assembly (GO:0006335)2.90205613
58DNA replication-dependent nucleosome organization (GO:0034723)2.90205613
59regulation of pigment cell differentiation (GO:0050932)2.87532626
60histone mRNA metabolic process (GO:0008334)2.87222575
61somite rostral/caudal axis specification (GO:0032525)2.86948171
62organelle disassembly (GO:1903008)2.85957627
63tRNA processing (GO:0008033)2.85800817
64primary amino compound metabolic process (GO:1901160)2.85384100
65establishment of protein localization to Golgi (GO:0072600)2.82946151
66mitochondrial DNA replication (GO:0006264)2.82329291
67endoderm formation (GO:0001706)2.80876813
68regulation of endothelial cell differentiation (GO:0045601)2.77217425
69regulation of mitochondrial fission (GO:0090140)2.76882386
70natural killer cell differentiation (GO:0001779)2.76713515
71mitochondrial fission (GO:0000266)2.76273208
72regulation of helicase activity (GO:0051095)2.72906101
73histone H4-K8 acetylation (GO:0043982)2.72454741
74histone H4-K5 acetylation (GO:0043981)2.72454741
75spermatid nucleus differentiation (GO:0007289)2.72048448
76C-terminal protein lipidation (GO:0006501)2.70992137
77regulation of spindle checkpoint (GO:0090231)2.68574985
78mitochondrial RNA metabolic process (GO:0000959)2.67731435
79cullin deneddylation (GO:0010388)2.67509721
80histone mRNA catabolic process (GO:0071044)2.67055740
81histone-serine phosphorylation (GO:0035404)2.66733968
82phosphate ion transport (GO:0006817)2.66626918
83protein targeting to Golgi (GO:0000042)2.63753461
84neuronal stem cell maintenance (GO:0097150)2.63566856
85peptidyl-threonine dephosphorylation (GO:0035970)2.61341903
86C-terminal protein amino acid modification (GO:0018410)2.59681189
87glucosamine-containing compound catabolic process (GO:1901072)2.59454545
88negative regulation of membrane potential (GO:0045837)2.55626437
89cAMP catabolic process (GO:0006198)2.53539205
90microtubule depolymerization (GO:0007019)2.52015423
91RNA modification (GO:0009451)2.50223736
92negative regulation of thymocyte apoptotic process (GO:0070244)2.49495010
93glycolipid biosynthetic process (GO:0009247)2.48903162
94magnesium ion transport (GO:0015693)2.44286743
95RNA destabilization (GO:0050779)2.40388702
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.37786641
97nucleobase catabolic process (GO:0046113)2.37405289
98tRNA metabolic process (GO:0006399)2.35168382
99positive regulation of T cell cytokine production (GO:0002726)2.34541265
100DNA deamination (GO:0045006)2.32726522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.32044590
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.72046630
3GATA1_22025678_ChIP-Seq_K562_Human4.52538290
4ZNF274_21170338_ChIP-Seq_K562_Hela3.22193561
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.15538875
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15240494
7VDR_22108803_ChIP-Seq_LS180_Human3.12700944
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.98504528
9FUS_26573619_Chip-Seq_HEK293_Human2.83037164
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74541192
11VDR_23849224_ChIP-Seq_CD4+_Human2.73748555
12IGF1R_20145208_ChIP-Seq_DFB_Human2.65801702
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63133371
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60544562
15ELK1_19687146_ChIP-ChIP_HELA_Human2.52239425
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.49284946
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32672748
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30844680
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.28494666
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16443685
21FOXP3_21729870_ChIP-Seq_TREG_Human2.07170112
22IRF1_19129219_ChIP-ChIP_H3396_Human1.98778622
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.95902167
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94567412
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82334411
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80729272
27EWS_26573619_Chip-Seq_HEK293_Human1.77188099
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74351773
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.73159239
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72918111
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71854724
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67799309
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.65071972
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64609903
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58980724
36CIITA_25753668_ChIP-Seq_RAJI_Human1.57644071
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56528518
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52961562
39ER_23166858_ChIP-Seq_MCF-7_Human1.47134434
40GABP_19822575_ChIP-Seq_HepG2_Human1.41164067
41MYC_18940864_ChIP-ChIP_HL60_Human1.40932597
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38553261
43GATA3_26560356_Chip-Seq_TH2_Human1.35413175
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.35407766
45GBX2_23144817_ChIP-Seq_PC3_Human1.32235179
46E2F7_22180533_ChIP-Seq_HELA_Human1.29873416
47TAF15_26573619_Chip-Seq_HEK293_Human1.28733610
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.28660512
49P300_19829295_ChIP-Seq_ESCs_Human1.27240213
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27058990
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26480376
52PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25425331
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20732405
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18671219
55MYB_26560356_Chip-Seq_TH2_Human1.17144692
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.14837695
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14314519
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14305754
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.12389092
60CBP_20019798_ChIP-Seq_JUKART_Human1.08786810
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08786810
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08657549
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08449729
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05430767
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04456140
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.03743811
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03186127
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.02431447
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02373870
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00460369
71TP53_22573176_ChIP-Seq_HFKS_Human0.99755845
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97176514
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96867625
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96069421
75CDX2_22108803_ChIP-Seq_LS180_Human0.95222185
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95141056
77RUNX_20019798_ChIP-Seq_JUKART_Human0.93972557
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92095449
79NCOR_22424771_ChIP-Seq_293T_Human0.91620124
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91123449
81DCP1A_22483619_ChIP-Seq_HELA_Human0.89913045
82E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89209582
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88792163
84E2F1_21310950_ChIP-Seq_MCF-7_Human0.88770599
85POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88451981
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87581261
87ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87474807
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87448580
89RXR_22108803_ChIP-Seq_LS180_Human0.83960939
90TTF2_22483619_ChIP-Seq_HELA_Human0.83525677
91SOX2_19829295_ChIP-Seq_ESCs_Human0.82932242
92NANOG_19829295_ChIP-Seq_ESCs_Human0.82932242
93ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82846334
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82799396
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82633319
96NELFA_20434984_ChIP-Seq_ESCs_Mouse0.82561283
97XRN2_22483619_ChIP-Seq_HELA_Human0.82355456
98SALL4_22934838_ChIP-ChIP_CD34+_Human0.82290772
99MYC_18358816_ChIP-ChIP_MESCs_Mouse0.81097389
100GATA3_27048872_Chip-Seq_THYMUS_Human0.80443172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.20753187
2MP0003806_abnormal_nucleotide_metabolis2.54589200
3MP0002009_preneoplasia2.38589412
4MP0005083_abnormal_biliary_tract2.37858194
5MP0003890_abnormal_embryonic-extraembry2.36526325
6MP0008877_abnormal_DNA_methylation2.29354654
7MP0008995_early_reproductive_senescence2.28732451
8MP0005253_abnormal_eye_physiology2.13549247
9MP0003136_yellow_coat_color2.10766230
10MP0009697_abnormal_copulation2.09735736
11MP0006035_abnormal_mitochondrial_morpho2.09285424
12MP0006072_abnormal_retinal_apoptosis2.07230246
13MP0002938_white_spotting2.03747027
14MP0001529_abnormal_vocalization2.01229446
15MP0005367_renal/urinary_system_phenotyp1.99447424
16MP0000516_abnormal_urinary_system1.99447424
17MP0003878_abnormal_ear_physiology1.97404441
18MP0005377_hearing/vestibular/ear_phenot1.97404441
19MP0005646_abnormal_pituitary_gland1.97217015
20MP0002138_abnormal_hepatobiliary_system1.95309079
21MP0002102_abnormal_ear_morphology1.92525840
22MP0008058_abnormal_DNA_repair1.91102875
23MP0005499_abnormal_olfactory_system1.88866810
24MP0005394_taste/olfaction_phenotype1.88866810
25MP0001764_abnormal_homeostasis1.86536425
26MP0004147_increased_porphyrin_level1.84984896
27MP0003786_premature_aging1.84826432
28MP0005075_abnormal_melanosome_morpholog1.83143241
29MP0002653_abnormal_ependyma_morphology1.78918768
30MP0004133_heterotaxia1.74745999
31MP0003252_abnormal_bile_duct1.74541270
32MP0001984_abnormal_olfaction1.64787348
33MP0003787_abnormal_imprinting1.63261796
34MP0006054_spinal_hemorrhage1.61983809
35MP0010094_abnormal_chromosome_stability1.61575085
36MP0003693_abnormal_embryo_hatching1.60375974
37MP0008789_abnormal_olfactory_epithelium1.57309446
38MP0008872_abnormal_physiological_respon1.54285573
39MP0002095_abnormal_skin_pigmentation1.51925199
40MP0002163_abnormal_gland_morphology1.50695233
41MP0003724_increased_susceptibility_to1.50217613
42MP0004043_abnormal_pH_regulation1.46773638
43MP0006292_abnormal_olfactory_placode1.43630826
44MP0002396_abnormal_hematopoietic_system1.40880853
45MP0003763_abnormal_thymus_physiology1.38338555
46MP0005085_abnormal_gallbladder_physiolo1.35487597
47MP0005379_endocrine/exocrine_gland_phen1.32480392
48MP0002132_abnormal_respiratory_system1.30694935
49MP0005670_abnormal_white_adipose1.30022259
50MP0002822_catalepsy1.29066844
51MP0003567_abnormal_fetal_cardiomyocyte1.21633405
52MP0003828_pulmonary_edema1.21438888
53MP0008961_abnormal_basal_metabolism1.19119485
54MP0000358_abnormal_cell_content/1.14723299
55MP0000538_abnormal_urinary_bladder1.14080115
56MP0005084_abnormal_gallbladder_morpholo1.12250826
57MP0004957_abnormal_blastocyst_morpholog1.12105159
58MP0003111_abnormal_nucleus_morphology1.11177646
59MP0008932_abnormal_embryonic_tissue1.07834242
60MP0002928_abnormal_bile_duct1.07271045
61MP0005551_abnormal_eye_electrophysiolog1.06731600
62MP0005220_abnormal_exocrine_pancreas1.02081644
63MP0001661_extended_life_span1.00958395
64MP0004142_abnormal_muscle_tone1.00066010
65MP0001929_abnormal_gametogenesis0.96874374
66MP0002006_tumorigenesis0.96711501
67MP0002751_abnormal_autonomic_nervous0.93316333
68MP0001486_abnormal_startle_reflex0.92918341
69MP0001270_distended_abdomen0.92753222
70MP0004215_abnormal_myocardial_fiber0.90755718
71MP0000653_abnormal_sex_gland0.90494029
72MP0002332_abnormal_exercise_endurance0.89767853
73MP0003698_abnormal_male_reproductive0.89278200
74MP0002166_altered_tumor_susceptibility0.89146531
75MP0003077_abnormal_cell_cycle0.88872555
76MP0005171_absent_coat_pigmentation0.88865759
77MP0001119_abnormal_female_reproductive0.88319640
78MP0001800_abnormal_humoral_immune0.88097688
79MP0005671_abnormal_response_to0.87833131
80MP0001145_abnormal_male_reproductive0.86160497
81MP0004019_abnormal_vitamin_homeostasis0.85810810
82MP0005391_vision/eye_phenotype0.84188806
83MP0009765_abnormal_xenobiotic_induced0.83821039
84MP0002735_abnormal_chemical_nociception0.82855740
85MP0000427_abnormal_hair_cycle0.82493805
86MP0005360_urolithiasis0.77869987
87MP0001485_abnormal_pinna_reflex0.76552128
88MP0006276_abnormal_autonomic_nervous0.76404665
89MP0001502_abnormal_circadian_rhythm0.74776490
90MP0000703_abnormal_thymus_morphology0.73758813
91MP0000647_abnormal_sebaceous_gland0.73248679
92MP0001756_abnormal_urination0.71877005
93MP0002160_abnormal_reproductive_system0.71731909
94MP0003959_abnormal_lean_body0.71568498
95MP0002736_abnormal_nociception_after0.70079819
96MP0000026_abnormal_inner_ear0.69836575
97MP0002210_abnormal_sex_determination0.69358480
98MP0004484_altered_response_of0.68254298
99MP0001986_abnormal_taste_sensitivity0.67869329
100MP0006036_abnormal_mitochondrial_physio0.67113915

Predicted human phenotypes

RankGene SetZ-score
1Dyschromatopsia (HP:0007641)3.99561621
2Abnormality of alanine metabolism (HP:0010916)3.79998555
3Hyperalaninemia (HP:0003348)3.79998555
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.79998555
5Generalized aminoaciduria (HP:0002909)3.56080432
6Congenital sensorineural hearing impairment (HP:0008527)3.43217434
7Abnormality of homocysteine metabolism (HP:0010919)3.39872201
8Homocystinuria (HP:0002156)3.39872201
9Abnormal auditory evoked potentials (HP:0006958)3.33920177
10Chronic hepatic failure (HP:0100626)3.29156543
11Constricted visual fields (HP:0001133)3.24191166
12Intestinal atresia (HP:0011100)3.20330000
13Attenuation of retinal blood vessels (HP:0007843)3.16183781
14Carpal bone hypoplasia (HP:0001498)3.12516492
15White forelock (HP:0002211)3.07452257
16Abnormality of B cell number (HP:0010975)3.05652753
17Pancreatic cysts (HP:0001737)3.04334987
18Chorioretinal atrophy (HP:0000533)2.82231709
19Patchy hypopigmentation of hair (HP:0011365)2.81897409
20Abnormal biliary tract physiology (HP:0012439)2.81542578
21Bile duct proliferation (HP:0001408)2.81542578
22Rib fusion (HP:0000902)2.80390189
23Dyskinesia (HP:0100660)2.71924323
24Anomalous pulmonary venous return (HP:0010772)2.70343794
25Renal cortical cysts (HP:0000803)2.68136426
26True hermaphroditism (HP:0010459)2.64671884
27Pancreatic fibrosis (HP:0100732)2.58311865
28Abnormality of the renal collecting system (HP:0004742)2.56767633
29Hypoplastic pelvis (HP:0008839)2.55123904
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52717888
31Duplicated collecting system (HP:0000081)2.50627590
32Disproportionate short-trunk short stature (HP:0003521)2.49514345
33Abnormality of the renal cortex (HP:0011035)2.47834620
34Pendular nystagmus (HP:0012043)2.44988962
35Chromsome breakage (HP:0040012)2.42073894
36Abnormality of serum amino acid levels (HP:0003112)2.37953223
37Abnormality of the pulmonary veins (HP:0011718)2.34384124
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.33898129
393-Methylglutaconic aciduria (HP:0003535)2.32750986
40Abnormality of DNA repair (HP:0003254)2.30545854
41Birth length less than 3rd percentile (HP:0003561)2.30496833
42Progressive cerebellar ataxia (HP:0002073)2.30272540
43Anal stenosis (HP:0002025)2.22621244
44B lymphocytopenia (HP:0010976)2.21292041
45Progressive external ophthalmoplegia (HP:0000590)2.20536954
46Premature graying of hair (HP:0002216)2.19769711
47Genetic anticipation (HP:0003743)2.17868774
48Central scotoma (HP:0000603)2.14230914
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.14189219
50Abolished electroretinogram (ERG) (HP:0000550)2.13577490
51Abnormality of methionine metabolism (HP:0010901)2.12223819
52J-shaped sella turcica (HP:0002680)2.07358258
53Sloping forehead (HP:0000340)2.06827076
54Prostate neoplasm (HP:0100787)2.05878557
55Congenital stationary night blindness (HP:0007642)2.04666692
56Abnormal umbilical cord blood vessels (HP:0011403)2.02117704
57Single umbilical artery (HP:0001195)2.02117704
58Abnormality of the fetal cardiovascular system (HP:0010948)2.02117704
59Short tibia (HP:0005736)2.01665537
60Abnormality of sulfur amino acid metabolism (HP:0004339)1.99494308
61Hypoplastic iliac wings (HP:0002866)1.98303965
62Anencephaly (HP:0002323)1.97393061
63Deformed sella turcica (HP:0002681)1.96650448
64Autoimmune hemolytic anemia (HP:0001890)1.94902588
65Tongue fasciculations (HP:0001308)1.92445874
66Abnormality of the anterior horn cell (HP:0006802)1.91810153
67Degeneration of anterior horn cells (HP:0002398)1.91810153
68Granulocytopenia (HP:0001913)1.88248915
69Median cleft lip (HP:0000161)1.88081086
70Abnormality of chromosome stability (HP:0003220)1.85037430
71Supernumerary spleens (HP:0009799)1.84194915
72Hyperglycinemia (HP:0002154)1.83224709
73Postaxial foot polydactyly (HP:0001830)1.82292007
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.81847830
75Autoimmune thrombocytopenia (HP:0001973)1.81770597
76Poor speech (HP:0002465)1.80071891
77Abnormality of eosinophils (HP:0001879)1.79386364
78Type 2 muscle fiber atrophy (HP:0003554)1.74936047
79Heterochromia iridis (HP:0001100)1.73032834
80Abnormality of the prostate (HP:0008775)1.72469537
81Cystic liver disease (HP:0006706)1.71911489
82Stomach cancer (HP:0012126)1.71270299
83Menstrual irregularities (HP:0000858)1.71152293
84Abnormality of pyrimidine metabolism (HP:0004353)1.70868826
85Medial flaring of the eyebrow (HP:0010747)1.70487136
86Hematochezia (HP:0002573)1.69815206
87Broad alveolar ridges (HP:0000187)1.69324801
88Abnormality of the odontoid process (HP:0003310)1.67890590
89Nephrogenic diabetes insipidus (HP:0009806)1.67887071
90Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67626744
91Absent forearm bone (HP:0003953)1.66691297
92Aplasia involving forearm bones (HP:0009822)1.66691297
93Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66341554
94Stenosis of the external auditory canal (HP:0000402)1.65712745
95Absent radius (HP:0003974)1.65285832
96Anhidrosis (HP:0000970)1.63759274
97Cellular immunodeficiency (HP:0005374)1.63554189
98Portal hypertension (HP:0001409)1.63328520
99Irregular epiphyses (HP:0010582)1.61497059
100Aplastic anemia (HP:0001915)1.60855120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.44762702
2FRK3.40765344
3TXK3.33721351
4BRD43.18620826
5CDK192.87957627
6MAP3K142.65183363
7BRSK22.61322264
8ZAK2.52877871
9TLK12.51102900
10CAMKK22.45350230
11EIF2AK32.13253399
12ACVR1B2.06169961
13PLK42.05732882
14NEK62.04917449
15BMPR1B1.78576516
16EIF2AK21.75897268
17ERBB31.73358841
18FLT31.68559382
19BCR1.65048615
20WNK31.56979766
21VRK11.54292317
22MAP4K11.49308917
23IKBKE1.47489659
24LATS11.41894653
25NUAK11.41706451
26BRSK11.41442652
27PKN21.40234131
28MAP2K31.35671235
29SRPK11.33573600
30CSNK1A1L1.23923050
31JAK31.19331707
32CSNK1G31.17557961
33GRK61.16273276
34SIK31.13737940
35TRIM281.08305737
36MARK30.97681516
37CAMKK10.95658140
38TAOK30.95304491
39BTK0.93248570
40CSNK1G10.92649968
41IKBKB0.90762724
42MAP2K20.90227450
43MKNK20.90046986
44GRK70.88766399
45MAP3K60.88024961
46TBK10.87721010
47MAP3K40.87464755
48CDK60.85647092
49ADRBK10.83521623
50CDK90.82960830
51TEC0.82139473
52WEE10.81645647
53CSNK1G20.81557172
54TGFBR10.78806810
55FGR0.77524897
56OXSR10.73877380
57INSRR0.73130067
58SCYL20.72242252
59NTRK20.71474769
60RPS6KA40.71458160
61PINK10.69566687
62STK160.69338171
63PLK30.69103143
64BMPR20.65596511
65GRK10.65439488
66LCK0.65261355
67CDK80.63006717
68ATR0.62095039
69RPS6KA50.61816980
70AURKB0.60154151
71MAP3K30.59822895
72ERBB40.59148250
73MELK0.58842898
74AURKA0.58741632
75PDK20.57209617
76BCKDK0.57101206
77STK38L0.56917520
78CHEK20.56204800
79CDK40.55140641
80ADRBK20.54956932
81PIM10.53337976
82ITK0.53043206
83PLK10.52329502
84MKNK10.50617273
85DYRK20.46482570
86LYN0.44985607
87YES10.43395697
88CHUK0.43030640
89WNK40.42777836
90MAPK110.39507918
91PRKCQ0.38990956
92CSNK1A10.38584052
93LMTK20.38124752
94IGF1R0.36910514
95MAP3K70.36786673
96MAP2K10.36751863
97PIK3CA0.36554505
98TNK20.36391007
99CDK70.36385930
100EGFR0.35355594

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.94869577
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.82206463
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.80412588
4Homologous recombination_Homo sapiens_hsa034402.58566189
5Collecting duct acid secretion_Homo sapiens_hsa049662.38213317
6Nitrogen metabolism_Homo sapiens_hsa009102.36226429
7RNA polymerase_Homo sapiens_hsa030202.31605053
8Systemic lupus erythematosus_Homo sapiens_hsa053222.28842892
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17290948
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16915338
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.06705258
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06532326
13Selenocompound metabolism_Homo sapiens_hsa004502.05864871
14Fanconi anemia pathway_Homo sapiens_hsa034601.98873007
15RNA degradation_Homo sapiens_hsa030181.94868149
16Sulfur relay system_Homo sapiens_hsa041221.93645347
17Regulation of autophagy_Homo sapiens_hsa041401.92080828
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87329804
19Spliceosome_Homo sapiens_hsa030401.83849091
20Sulfur metabolism_Homo sapiens_hsa009201.78585438
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64719296
22Alcoholism_Homo sapiens_hsa050341.61611934
23Basal transcription factors_Homo sapiens_hsa030221.57535541
24RNA transport_Homo sapiens_hsa030131.52916137
25Graft-versus-host disease_Homo sapiens_hsa053321.52841835
26Taste transduction_Homo sapiens_hsa047421.51563660
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51495418
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.49329335
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.46290916
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41782543
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38703274
32Circadian rhythm_Homo sapiens_hsa047101.30614919
33Oxidative phosphorylation_Homo sapiens_hsa001901.27153816
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19239783
35Non-homologous end-joining_Homo sapiens_hsa034501.18543749
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18513844
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10093091
38Arginine biosynthesis_Homo sapiens_hsa002201.09008580
39Legionellosis_Homo sapiens_hsa051341.08704129
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07371129
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07321750
42Morphine addiction_Homo sapiens_hsa050321.06012655
43Purine metabolism_Homo sapiens_hsa002301.05289142
44Asthma_Homo sapiens_hsa053101.04755324
45Ribosome_Homo sapiens_hsa030101.04529118
46Pyrimidine metabolism_Homo sapiens_hsa002401.00919068
47mRNA surveillance pathway_Homo sapiens_hsa030150.98702904
48Primary immunodeficiency_Homo sapiens_hsa053400.96077308
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92659884
50Protein export_Homo sapiens_hsa030600.92644570
51Autoimmune thyroid disease_Homo sapiens_hsa053200.91388066
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.90194113
53Parkinsons disease_Homo sapiens_hsa050120.89792229
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89732151
55Rheumatoid arthritis_Homo sapiens_hsa053230.87322981
56Proteasome_Homo sapiens_hsa030500.87311771
57Phototransduction_Homo sapiens_hsa047440.85835624
58T cell receptor signaling pathway_Homo sapiens_hsa046600.85544877
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80687949
60Biosynthesis of amino acids_Homo sapiens_hsa012300.79958204
61Olfactory transduction_Homo sapiens_hsa047400.79735395
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79189040
63Allograft rejection_Homo sapiens_hsa053300.78508967
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72849687
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72649503
66GABAergic synapse_Homo sapiens_hsa047270.69480422
67Chemical carcinogenesis_Homo sapiens_hsa052040.66714348
68DNA replication_Homo sapiens_hsa030300.63819805
69Steroid biosynthesis_Homo sapiens_hsa001000.62489291
70Propanoate metabolism_Homo sapiens_hsa006400.62155042
71p53 signaling pathway_Homo sapiens_hsa041150.62008184
72Peroxisome_Homo sapiens_hsa041460.60296150
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60105361
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60101331
75Nucleotide excision repair_Homo sapiens_hsa034200.59969876
76Metabolic pathways_Homo sapiens_hsa011000.59301844
77Viral carcinogenesis_Homo sapiens_hsa052030.57627812
78Cell cycle_Homo sapiens_hsa041100.56651785
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56299839
80Mismatch repair_Homo sapiens_hsa034300.56200787
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54493541
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52185038
83Vibrio cholerae infection_Homo sapiens_hsa051100.51402527
84Renin-angiotensin system_Homo sapiens_hsa046140.50293088
85Type I diabetes mellitus_Homo sapiens_hsa049400.49875867
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.48771919
87Butanoate metabolism_Homo sapiens_hsa006500.47434694
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.46438825
89Renin secretion_Homo sapiens_hsa049240.45462820
90Carbon metabolism_Homo sapiens_hsa012000.43011844
91Retinol metabolism_Homo sapiens_hsa008300.42400788
92Huntingtons disease_Homo sapiens_hsa050160.40521606
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39764307
94Herpes simplex infection_Homo sapiens_hsa051680.39633531
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38920357
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38542112
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.35509841
98Galactose metabolism_Homo sapiens_hsa000520.32831010
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.32755913
100Antigen processing and presentation_Homo sapiens_hsa046120.32269060

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