ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	rRNA modification (GO:0000154)	5.37932663
2	rRNA methylation (GO:0031167)	5.04677113
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.84075627
4	ATP synthesis coupled proton transport (GO:0015986)	4.74022362
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.74022362
6	proteasome assembly (GO:0043248)	4.51968797
7	xenobiotic catabolic process (GO:0042178)	4.51934145
8	artery smooth muscle contraction (GO:0014824)	4.45215816
9	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.37747276
10	neutrophil activation involved in immune response (GO:0002283)	4.21475446
11	regulation of translational fidelity (GO:0006450)	4.04191908
12	GTP biosynthetic process (GO:0006183)	3.77137316
13	mitochondrial calcium ion transport (GO:0006851)	3.74069020
14	tonic smooth muscle contraction (GO:0014820)	3.67173883
15	respiratory chain complex IV assembly (GO:0008535)	3.63882392
16	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.63789979
17	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.63789979
18	NADPH regeneration (GO:0006740)	3.54921188
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.53442769
20	NADH dehydrogenase complex assembly (GO:0010257)	3.53442769
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.53442769
22	neutrophil activation (GO:0042119)	3.53247815
23	ribosomal large subunit biogenesis (GO:0042273)	3.50776255
24	regulation of mitochondrial translation (GO:0070129)	3.50615630
25	basic amino acid transport (GO:0015802)	3.47037753
26	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.46649063
27	UTP biosynthetic process (GO:0006228)	3.42541494
28	mitotic metaphase plate congression (GO:0007080)	3.41703161
29	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.35761129
30	fat-soluble vitamin biosynthetic process (GO:0042362)	3.34642015
31	pseudouridine synthesis (GO:0001522)	3.34609412
32	DNA deamination (GO:0045006)	3.32371688
33	regulation of cellular amino acid metabolic process (GO:0006521)	3.31527370
34	ribosomal small subunit assembly (GO:0000028)	3.29336024
35	protein localization to kinetochore (GO:0034501)	3.25831722
36	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.25260364
37	L-phenylalanine metabolic process (GO:0006558)	3.25260364
38	vitamin biosynthetic process (GO:0009110)	3.20341427
39	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.19839107
40	guanosine-containing compound biosynthetic process (GO:1901070)	3.17009777
41	respiratory electron transport chain (GO:0022904)	3.16216616
42	cytochrome complex assembly (GO:0017004)	3.15518597
43	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.14339038
44	protein complex biogenesis (GO:0070271)	3.13926932
45	regulation of metalloenzyme activity (GO:0048552)	3.13811317
46	protein-cofactor linkage (GO:0018065)	3.12938892
47	electron transport chain (GO:0022900)	3.12759446
48	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.12460021
49	UTP metabolic process (GO:0046051)	3.11110560
50	dicarboxylic acid biosynthetic process (GO:0043650)	3.10225269
51	metallo-sulfur cluster assembly (GO:0031163)	3.08124360
52	iron-sulfur cluster assembly (GO:0016226)	3.08124360
53	regulation of oxidative phosphorylation (GO:0002082)	3.07230247
54	water-soluble vitamin biosynthetic process (GO:0042364)	3.06040838
55	pentose-phosphate shunt (GO:0006098)	3.04784679
56	granulocyte activation (GO:0036230)	3.03865976
57	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.03325086
58	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.03108689
59	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.00052911
60	regulation of cellular respiration (GO:0043457)	2.98045550
61	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.97252268
62	CTP metabolic process (GO:0046036)	2.96366336
63	CTP biosynthetic process (GO:0006241)	2.96366336
64	spliceosomal snRNP assembly (GO:0000387)	2.94773035
65	oxaloacetate metabolic process (GO:0006107)	2.94768618
66	DNA replication checkpoint (GO:0000076)	2.94341748
67	NADH metabolic process (GO:0006734)	2.90097314
68	maturation of 5.8S rRNA (GO:0000460)	2.85743932
69	GDP-mannose metabolic process (GO:0019673)	2.82811209
70	L-methionine salvage (GO:0071267)	2.81581579
71	L-methionine biosynthetic process (GO:0071265)	2.81581579
72	amino acid salvage (GO:0043102)	2.81581579
73	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.79185987
74	mitochondrial respiratory chain complex assembly (GO:0033108)	2.76787345
75	protein deneddylation (GO:0000338)	2.76580614
76	histone mRNA metabolic process (GO:0008334)	2.76241018
77	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.75867742
78	ribosome assembly (GO:0042255)	2.75556644
79	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.74600131
80	termination of RNA polymerase III transcription (GO:0006386)	2.74600131
81	cullin deneddylation (GO:0010388)	2.74526869
82	interferon-gamma secretion (GO:0072643)	2.74043164
83	protein neddylation (GO:0045116)	2.73953302
84	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.73260446
85	glutamine family amino acid biosynthetic process (GO:0009084)	2.72954905
86	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.72217103
87	negative regulation of ligase activity (GO:0051352)	2.72217103
88	ATP biosynthetic process (GO:0006754)	2.72025411
89	negative regulation of macrophage differentiation (GO:0045650)	2.71808373
90	prostanoid biosynthetic process (GO:0046457)	2.71501097
91	prostaglandin biosynthetic process (GO:0001516)	2.71501097
92	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.69594893
93	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.69594893
94	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.66896862
95	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.66774856
96	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.64744547
97	daunorubicin metabolic process (GO:0044597)	2.64634130
98	polyketide metabolic process (GO:0030638)	2.64634130
99	doxorubicin metabolic process (GO:0044598)	2.64634130
100	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.63248128

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.54223875
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.21048797
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.76894852
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.31772118
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.02157713
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.97922432
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.92690905
8	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	2.63540918
9	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.49687171
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.42969338
11	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.41878708
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.38934976
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.33604787
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.32773014
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.22633659
16	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.21277088
17	VDR_22108803_ChIP-Seq_LS180_Human	2.20432153
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.15017758
19	HOXB4_20404135_ChIP-ChIP_EML_Mouse	2.13125991
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.13070688
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.09801309
22	IRF1_19129219_ChIP-ChIP_H3396_Human	2.07614355
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.06834301
24	ELK1_19687146_ChIP-ChIP_HELA_Human	2.06589811
25	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.06043262
26	FOXP3_21729870_ChIP-Seq_TREG_Human	2.02088482
27	E2F7_22180533_ChIP-Seq_HELA_Human	2.01278750
28	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.99208470
29	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.85483622
30	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.83191026
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.81187236
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.72146143
33	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.71001539
34	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.61111447
35	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.60171963
36	AR_21909140_ChIP-Seq_LNCAP_Human	1.58876010
37	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.57734593
38	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.55088659
39	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.54244258
40	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54163435
41	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.52597683
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.45450241
43	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.44478233
44	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.42606946
45	XRN2_22483619_ChIP-Seq_HELA_Human	1.42280483
46	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.41922225
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.39172527
48	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.38815932
49	GATA4_25053715_ChIP-Seq_YYC3_Human	1.34126711
50	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.33265175
51	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.27131891
52	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.25828822
53	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.22316202
54	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.21994986
55	ZNF274_21170338_ChIP-Seq_K562_Hela	1.21702179
56	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.20758526
57	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.18758632
58	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17992847
59	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.17735192
60	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.17170508
61	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.14461903
62	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.14070966
63	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.13064889
64	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.12764626
65	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.12012658
66	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.10580680
67	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.09996183
68	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.09988204
69	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.09958542
70	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.07609972
71	ERG_20517297_ChIP-Seq_VCAP_Human	1.06320918
72	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.04909111
73	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.04908617
74	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.04821110
75	TTF2_22483619_ChIP-Seq_HELA_Human	1.01736874
76	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.01233716
77	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.00152285
78	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.99678852
79	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99411790
80	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.99013312
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.98191294
82	SPI1_23547873_ChIP-Seq_NB4_Human	0.97991891
83	AR_20517297_ChIP-Seq_VCAP_Human	0.95839919
84	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.95674860
85	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.95427658
86	GATA6_25053715_ChIP-Seq_YYC3_Human	0.95409565
87	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.95246483
88	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.93276299
89	GATA1_22025678_ChIP-Seq_K562_Human	0.91893521
90	P300_27268052_Chip-Seq_Bcells_Human	0.91618016
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.91233919
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.91233919
93	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.90815653
94	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.85009057
95	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.83172157
96	SPI1_20517297_ChIP-Seq_HL60_Human	0.83064645
97	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.82664827
98	BCOR_27268052_Chip-Seq_Bcells_Human	0.82163272
99	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.81921939
100	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.80657099

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	5.46319096
2	MP0005360_urolithiasis	3.94282193
3	MP0005084_abnormal_gallbladder_morpholo	3.03511628
4	MP0009697_abnormal_copulation	3.00816238
5	MP0010386_abnormal_urinary_bladder	3.00250777
6	MP0006054_spinal_hemorrhage	2.89309401
7	MP0008875_abnormal_xenobiotic_pharmacok	2.87126553
8	MP0004147_increased_porphyrin_level	2.74308655
9	MP0005085_abnormal_gallbladder_physiolo	2.63835922
10	MP0003693_abnormal_embryo_hatching	2.55643304
11	MP0003252_abnormal_bile_duct	2.42538263
12	MP0002132_abnormal_respiratory_system	2.35335741
13	MP0006292_abnormal_olfactory_placode	2.34419115
14	MP0004957_abnormal_blastocyst_morpholog	2.30230424
15	MP0002139_abnormal_hepatobiliary_system	2.29421635
16	MP0003724_increased_susceptibility_to	2.29383085
17	MP0010234_abnormal_vibrissa_follicle	2.27064866
18	MP0002277_abnormal_respiratory_mucosa	2.19761212
19	MP0005365_abnormal_bile_salt	2.02372749
20	MP0001764_abnormal_homeostasis	2.00891787
21	MP0005379_endocrine/exocrine_gland_phen	1.95909494
22	MP0002163_abnormal_gland_morphology	1.92401119
23	MP0009379_abnormal_foot_pigmentation	1.79732546
24	MP0003186_abnormal_redox_activity	1.72182594
25	MP0005319_abnormal_enzyme/_coenzyme	1.69758402
26	MP0005377_hearing/vestibular/ear_phenot	1.65066106
27	MP0003878_abnormal_ear_physiology	1.65066106
28	MP0008058_abnormal_DNA_repair	1.63176508
29	MP0000647_abnormal_sebaceous_gland	1.62952476
30	MP0008877_abnormal_DNA_methylation	1.60603231
31	MP0003195_calcinosis	1.60151871
32	MP0005058_abnormal_lysosome_morphology	1.57559852
33	MP0010352_gastrointestinal_tract_polyps	1.57162930
34	MP0001666_abnormal_nutrient_absorption	1.50746439
35	MP0002396_abnormal_hematopoietic_system	1.42694375
36	MP0005083_abnormal_biliary_tract	1.41909844
37	MP0001756_abnormal_urination	1.33724138
38	MP0005636_abnormal_mineral_homeostasis	1.33680518
39	MP0006035_abnormal_mitochondrial_morpho	1.32787792
40	MP0002736_abnormal_nociception_after	1.31868985
41	MP0009764_decreased_sensitivity_to	1.30553621
42	MP0004019_abnormal_vitamin_homeostasis	1.28544540
43	MP0005332_abnormal_amino_acid	1.27614926
44	MP0003866_abnormal_defecation	1.25370768
45	MP0003718_maternal_effect	1.24387615
46	MP0006036_abnormal_mitochondrial_physio	1.21667278
47	MP0002876_abnormal_thyroid_physiology	1.19831191
48	MP0005187_abnormal_penis_morphology	1.19632056
49	MP0008872_abnormal_physiological_respon	1.19138119
50	MP0008004_abnormal_stomach_pH	1.15702412
51	MP0001765_abnormal_ion_homeostasis	1.12445511
52	MP0003786_premature_aging	1.11565737
53	MP0005410_abnormal_fertilization	1.10265307
54	MP0001529_abnormal_vocalization	1.09905558
55	MP0002837_dystrophic_cardiac_calcinosis	1.09116639
56	MP0001835_abnormal_antigen_presentation	1.07133749
57	MP0000858_altered_metastatic_potential	1.04592679
58	MP0003567_abnormal_fetal_cardiomyocyte	1.00453342
59	MP0002138_abnormal_hepatobiliary_system	1.00238616
60	MP0003315_abnormal_perineum_morphology	0.99295582
61	MP0005670_abnormal_white_adipose	0.98806320
62	MP0008260_abnormal_autophagy	0.98223672
63	MP0002148_abnormal_hypersensitivity_rea	0.94496426
64	MP0003111_abnormal_nucleus_morphology	0.92289989
65	MP0008469_abnormal_protein_level	0.92189076
66	MP0010329_abnormal_lipoprotein_level	0.89867909
67	MP0010094_abnormal_chromosome_stability	0.88713477
68	MP0006082_CNS_inflammation	0.87289753
69	MP0005464_abnormal_platelet_physiology	0.87201878
70	MP0002693_abnormal_pancreas_physiology	0.85784487
71	MP0000358_abnormal_cell_content/	0.84522975
72	MP0000490_abnormal_crypts_of	0.82434874
73	MP0004264_abnormal_extraembryonic_tissu	0.82048819
74	MP0005671_abnormal_response_to	0.81770729
75	MP0000538_abnormal_urinary_bladder	0.81564544
76	MP0002796_impaired_skin_barrier	0.81112230
77	MP0002098_abnormal_vibrissa_morphology	0.80956716
78	MP0009643_abnormal_urine_homeostasis	0.80132484
79	MP0005167_abnormal_blood-brain_barrier	0.77558964
80	MP0000609_abnormal_liver_physiology	0.76433509
81	MP0005376_homeostasis/metabolism_phenot	0.76131334
82	MP0005248_abnormal_Harderian_gland	0.76043268
83	MP0005266_abnormal_metabolism	0.74712528
84	MP0002419_abnormal_innate_immunity	0.72496325
85	MP0000747_muscle_weakness	0.72096917
86	MP0003941_abnormal_skin_development	0.72031503
87	MP0000613_abnormal_salivary_gland	0.71602016
88	MP0002006_tumorigenesis	0.70339022
89	MP0002090_abnormal_vision	0.70151936
90	MP0000598_abnormal_liver_morphology	0.69248661
91	MP0002102_abnormal_ear_morphology	0.65930116
92	MP0002118_abnormal_lipid_homeostasis	0.65735516
93	MP0005166_decreased_susceptibility_to	0.65703248
94	MP0000465_gastrointestinal_hemorrhage	0.65694188
95	MP0009785_altered_susceptibility_to	0.64266939
96	MP0001730_embryonic_growth_arrest	0.64191998
97	MP0000470_abnormal_stomach_morphology	0.63776133
98	MP0001664_abnormal_digestion	0.63301195
99	MP0010678_abnormal_skin_adnexa	0.62277928
100	MP0004145_abnormal_muscle_electrophysio	0.60572737

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.03401866
2	Acute encephalopathy (HP:0006846)	4.81351313
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.47373740
4	Progressive macrocephaly (HP:0004481)	4.20649378
5	Mitochondrial inheritance (HP:0001427)	4.01328416
6	Increased CSF lactate (HP:0002490)	3.82322533
7	Hepatocellular necrosis (HP:0001404)	3.64777187
8	3-Methylglutaconic aciduria (HP:0003535)	3.46074624
9	Cerebral edema (HP:0002181)	3.45786881
10	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.44111474
11	Hepatic necrosis (HP:0002605)	3.44032133
12	Vacuolated lymphocytes (HP:0001922)	3.43308836
13	Abnormality of methionine metabolism (HP:0010901)	3.18448845
14	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.13716195
15	Abnormality of alanine metabolism (HP:0010916)	3.13716195
16	Hyperalaninemia (HP:0003348)	3.13716195
17	Lactic acidosis (HP:0003128)	3.07800081
18	Abnormality of urine glucose concentration (HP:0011016)	3.04043786
19	Glycosuria (HP:0003076)	3.04043786
20	Increased serum pyruvate (HP:0003542)	3.00996831
21	Lipid accumulation in hepatocytes (HP:0006561)	2.98605107
22	Secondary amenorrhea (HP:0000869)	2.94600966
23	Abnormality of serum amino acid levels (HP:0003112)	2.94163190
24	Dyschromatopsia (HP:0007641)	2.78176824
25	Lethargy (HP:0001254)	2.77173473
26	Respiratory failure (HP:0002878)	2.74116586
27	Optic disc pallor (HP:0000543)	2.73807921
28	Increased serum lactate (HP:0002151)	2.71489961
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.68066604
30	Hypothermia (HP:0002045)	2.67530138
31	Increased hepatocellular lipid droplets (HP:0006565)	2.66218630
32	Renal Fanconi syndrome (HP:0001994)	2.60451833
33	Hypoglycemic coma (HP:0001325)	2.57658200
34	Hypobetalipoproteinemia (HP:0003563)	2.57473997
35	Progressive hearing impairment (HP:0001730)	2.57077764
36	Premature ovarian failure (HP:0008209)	2.51824543
37	Abnormality of glycolysis (HP:0004366)	2.50768531
38	Methylmalonic aciduria (HP:0012120)	2.49747741
39	Hyperammonemia (HP:0001987)	2.43901533
40	Parakeratosis (HP:0001036)	2.43089315
41	Methylmalonic acidemia (HP:0002912)	2.42704693
42	Hyperglycinemia (HP:0002154)	2.39619007
43	Abnormal trabecular bone morphology (HP:0100671)	2.37420779
44	Palpitations (HP:0001962)	2.35872758
45	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.35134244
46	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.33805909
47	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.33805909
48	Cleft eyelid (HP:0000625)	2.30461849
49	Vascular calcification (HP:0004934)	2.30114833
50	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.29840818
51	Dicarboxylic aciduria (HP:0003215)	2.29840818
52	Micronodular cirrhosis (HP:0001413)	2.29537967
53	Testicular atrophy (HP:0000029)	2.28628962
54	CNS demyelination (HP:0007305)	2.28570667
55	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.26501767
56	Leukodystrophy (HP:0002415)	2.23684474
57	Proximal tubulopathy (HP:0000114)	2.21587175
58	Respiratory difficulties (HP:0002880)	2.21327660
59	Hepatocellular carcinoma (HP:0001402)	2.19755253
60	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.16373264
61	Type I transferrin isoform profile (HP:0003642)	2.16264361
62	Cerebral palsy (HP:0100021)	2.15856325
63	Hyperphosphaturia (HP:0003109)	2.14014553
64	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.12529691
65	Patent foramen ovale (HP:0001655)	2.11570687
66	Vaginal fistula (HP:0004320)	2.10768033
67	Renal tubular acidosis (HP:0001947)	2.10537685
68	Petechiae (HP:0000967)	2.10101237
69	Abnormality of proline metabolism (HP:0010907)	2.07092283
70	Hydroxyprolinuria (HP:0003080)	2.07092283
71	Spastic paraparesis (HP:0002313)	2.06047480
72	Increased muscle lipid content (HP:0009058)	2.05959273
73	Abnormality of renal resorption (HP:0011038)	2.03985556
74	Tongue fasciculations (HP:0001308)	2.03655715
75	Sparse eyelashes (HP:0000653)	2.03004494
76	Increased intramyocellular lipid droplets (HP:0012240)	2.02248563
77	Paraparesis (HP:0002385)	2.00224007
78	Rectovaginal fistula (HP:0000143)	1.97707139
79	Rectal fistula (HP:0100590)	1.97707139
80	Muscle fibrillation (HP:0010546)	1.97424357
81	Exercise intolerance (HP:0003546)	1.97319546
82	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.96639180
83	Microvesicular hepatic steatosis (HP:0001414)	1.96223923
84	Renal tubular dysfunction (HP:0000124)	1.94220728
85	Constricted visual fields (HP:0001133)	1.93099160
86	Hypoglycemic seizures (HP:0002173)	1.92417230
87	Fat malabsorption (HP:0002630)	1.92274758
88	Rickets (HP:0002748)	1.91116963
89	Aplastic anemia (HP:0001915)	1.88880091
90	Prolonged partial thromboplastin time (HP:0003645)	1.88184464
91	Steatorrhea (HP:0002570)	1.88009135
92	Xanthomatosis (HP:0000991)	1.87609731
93	Exertional dyspnea (HP:0002875)	1.87544673
94	Abnormal protein glycosylation (HP:0012346)	1.87214764
95	Abnormal glycosylation (HP:0012345)	1.87214764
96	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87214764
97	Abnormal protein N-linked glycosylation (HP:0012347)	1.87214764
98	Septate vagina (HP:0001153)	1.85304193
99	Reduced antithrombin III activity (HP:0001976)	1.85200827
100	Abnormality of the costochondral junction (HP:0000919)	1.84811870

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	5.15843193
2	ZAK	4.26296690
3	PBK	3.84760167
4	EPHA2	2.93691182
5	MAP3K12	2.93351836
6	BUB1	2.71867857
7	VRK1	2.56550461
8	FRK	2.51382225
9	VRK2	2.30266007
10	MST4	2.11987962
11	EIF2AK3	2.10930700
12	NEK1	1.85759314
13	PDK2	1.69095882
14	NUAK1	1.68134501
15	PAK4	1.65045141
16	RPS6KA5	1.61406864
17	MYLK	1.60441143
18	EIF2AK2	1.49138352
19	ILK	1.48830611
20	MAP3K14	1.39770084
21	IKBKE	1.36479887
22	SMG1	1.36045378
23	BMPR2	1.30436682
24	DAPK3	1.28747898
25	OXSR1	1.26457147
26	MAP4K2	1.23342799
27	LMTK2	1.20551984
28	PTK6	1.20530682
29	PASK	1.15144205
30	RPS6KB2	1.12517242
31	ACVR1B	1.11052459
32	TNIK	1.09100517
33	IKBKB	1.06342959
34	MAP2K2	1.03616419
35	BCR	1.03552016
36	GRK1	1.00978232
37	TBK1	0.97932582
38	BRSK2	0.96937363
39	RPS6KA4	0.95706150
40	PRKG2	0.92033498
41	CSNK1G3	0.89925337
42	AURKB	0.89328953
43	TAF1	0.88632534
44	ADRBK2	0.88082582
45	BLK	0.81438086
46	STK39	0.81336676
47	TXK	0.80094153
48	CDK6	0.78942463
49	SRPK1	0.78910804
50	FER	0.77922603
51	DAPK1	0.77484655
52	TRIM28	0.75286987
53	WEE1	0.73301914
54	CDC7	0.71357780
55	ERBB2	0.68260581
56	MAP2K6	0.68145871
57	AURKA	0.66793474
58	STK10	0.65138885
59	TNK2	0.64288821
60	SIK3	0.63965524
61	CDK9	0.63916568
62	PRKCD	0.63573396
63	PHKG1	0.63385492
64	PHKG2	0.63385492
65	SCYL2	0.62764878
66	IRAK1	0.62691468
67	STK4	0.60547036
68	CSNK1G1	0.59906529
69	GRK6	0.56520276
70	PLK3	0.56341158
71	PRKCQ	0.55545932
72	NME2	0.54480279
73	CAMK2G	0.54313979
74	BMPR1B	0.53273710
75	CHUK	0.53177728
76	CSNK1G2	0.53141973
77	DYRK2	0.51966273
78	PLK1	0.49451383
79	NME1	0.48700129
80	AKT2	0.47892405
81	EGFR	0.47736367
82	CSNK1A1L	0.47502207
83	TAOK3	0.46233797
84	EIF2AK1	0.45599349
85	CDK7	0.45557813
86	MAP3K8	0.45283817
87	ICK	0.45157227
88	ADRBK1	0.43561312
89	CAMK1	0.42855543
90	IRAK4	0.41846180
91	KDR	0.41574918
92	PRKCE	0.41321596
93	PRKCI	0.40562912
94	ABL2	0.40463243
95	BCKDK	0.39874116
96	STK3	0.39811000
97	BTK	0.38575179
98	TESK1	0.33819017
99	ALK	0.33280242
100	PAK1	0.33069844

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.94545518
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.47783432
3	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.08953278
4	Parkinsons disease_Homo sapiens_hsa05012	2.79058583
5	Ribosome_Homo sapiens_hsa03010	2.59552313
6	Sulfur metabolism_Homo sapiens_hsa00920	2.38293723
7	Sulfur relay system_Homo sapiens_hsa04122	2.36177823
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.33773153
9	RNA polymerase_Homo sapiens_hsa03020	2.22945249
10	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.13655593
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.10365433
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.01137431
13	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.00451601
14	Protein export_Homo sapiens_hsa03060	1.95162895
15	Arginine biosynthesis_Homo sapiens_hsa00220	1.93646138
16	One carbon pool by folate_Homo sapiens_hsa00670	1.79964495
17	Huntingtons disease_Homo sapiens_hsa05016	1.76523969
18	Alcoholism_Homo sapiens_hsa05034	1.67670311
19	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.65665446
20	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.62811188
21	Alzheimers disease_Homo sapiens_hsa05010	1.57907270
22	Fat digestion and absorption_Homo sapiens_hsa04975	1.53366267
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.52523133
24	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.52336888
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.49831517
26	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.49447308
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.46758170
28	Mismatch repair_Homo sapiens_hsa03430	1.44913726
29	Glutathione metabolism_Homo sapiens_hsa00480	1.43154584
30	DNA replication_Homo sapiens_hsa03030	1.40622492
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.34144146
32	Carbon metabolism_Homo sapiens_hsa01200	1.32796460
33	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.31630468
34	Pentose phosphate pathway_Homo sapiens_hsa00030	1.31371512
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.22442283
36	Collecting duct acid secretion_Homo sapiens_hsa04966	1.21775545
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.21424422
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.17979674
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.12611012
40	Folate biosynthesis_Homo sapiens_hsa00790	1.12185533
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11411556
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.10312459
43	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.09242652
44	Fatty acid elongation_Homo sapiens_hsa00062	1.03557115
45	Asthma_Homo sapiens_hsa05310	0.99350470
46	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.98535619
47	Peroxisome_Homo sapiens_hsa04146	0.97007414
48	Cardiac muscle contraction_Homo sapiens_hsa04260	0.95392661
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.93300577
50	Vibrio cholerae infection_Homo sapiens_hsa05110	0.90096257
51	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.88522702
52	Tyrosine metabolism_Homo sapiens_hsa00350	0.87018167
53	RNA transport_Homo sapiens_hsa03013	0.86886411
54	Homologous recombination_Homo sapiens_hsa03440	0.83889775
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82836564
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82614553
57	Metabolic pathways_Homo sapiens_hsa01100	0.81036466
58	Spliceosome_Homo sapiens_hsa03040	0.80798824
59	Arginine and proline metabolism_Homo sapiens_hsa00330	0.80379586
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.79260694
61	Fatty acid degradation_Homo sapiens_hsa00071	0.78668664
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.78383761
63	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.77335192
64	Basal transcription factors_Homo sapiens_hsa03022	0.77200861
65	Purine metabolism_Homo sapiens_hsa00230	0.76966446
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76296026
67	Histidine metabolism_Homo sapiens_hsa00340	0.73514923
68	Pancreatic secretion_Homo sapiens_hsa04972	0.73274223
69	Graft-versus-host disease_Homo sapiens_hsa05332	0.73000356
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69585688
71	Legionellosis_Homo sapiens_hsa05134	0.66919005
72	RNA degradation_Homo sapiens_hsa03018	0.66656051
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66378181
74	Nucleotide excision repair_Homo sapiens_hsa03420	0.64255406
75	Viral carcinogenesis_Homo sapiens_hsa05203	0.64124950
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.60089868
77	Caffeine metabolism_Homo sapiens_hsa00232	0.59397291
78	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.59092285
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58153088
80	Phenylalanine metabolism_Homo sapiens_hsa00360	0.58097617
81	Propanoate metabolism_Homo sapiens_hsa00640	0.57131413
82	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.57100287
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52122631
84	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.51590294
85	Allograft rejection_Homo sapiens_hsa05330	0.51527647
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.50646734
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.47104466
88	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.46752640
89	Type I diabetes mellitus_Homo sapiens_hsa04940	0.46615952
90	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.45618538
91	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43535833
92	Butanoate metabolism_Homo sapiens_hsa00650	0.43102174
93	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42419633
94	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.42101462
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41038429
96	Base excision repair_Homo sapiens_hsa03410	0.39550708
97	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.39374061
98	Fanconi anemia pathway_Homo sapiens_hsa03460	0.37561961
99	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.37114119
100	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.37106765

KRT18P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »