KRT19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)7.35375088
2intestinal epithelial cell development (GO:0060576)7.02972334
3maintenance of gastrointestinal epithelium (GO:0030277)6.85570824
4hepatocyte apoptotic process (GO:0097284)6.45121011
5hemidesmosome assembly (GO:0031581)6.33096691
6Golgi transport vesicle coating (GO:0048200)6.18499527
7COPI coating of Golgi vesicle (GO:0048205)6.18499527
8UDP-N-acetylglucosamine metabolic process (GO:0006047)6.07260394
9intestinal absorption (GO:0050892)5.42754682
10epithelial structure maintenance (GO:0010669)5.38760286
11O-glycan processing (GO:0016266)5.07402331
12calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.04149352
13epithelial cell-cell adhesion (GO:0090136)4.66625226
14desmosome organization (GO:0002934)4.59500862
15interferon-gamma secretion (GO:0072643)4.58103266
16establishment of skin barrier (GO:0061436)4.50826955
17multicellular organismal water homeostasis (GO:0050891)4.42852458
18branching involved in mammary gland duct morphogenesis (GO:0060444)4.40469156
19purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.35949663
203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.35949663
21digestive system process (GO:0022600)4.31711230
22actin filament depolymerization (GO:0030042)4.27088705
23flavonoid metabolic process (GO:0009812)4.25347735
24tight junction assembly (GO:0070830)4.12235405
25positive regulation of keratinocyte differentiation (GO:0045618)4.09499542
26retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.99303001
27activation of Rac GTPase activity (GO:0032863)3.98563553
28galactose catabolic process (GO:0019388)3.97565775
29sulfur amino acid catabolic process (GO:0000098)3.97189137
30ear development (GO:0043583)3.95094167
31regulation of chemokine secretion (GO:0090196)3.94689011
32positive regulation of pseudopodium assembly (GO:0031274)3.89843689
33regulation of respiratory burst (GO:0060263)3.88285189
34keratinocyte development (GO:0003334)3.87288769
35dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.80285331
36protein retention in ER lumen (GO:0006621)3.75964006
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.70430746
38antibacterial humoral response (GO:0019731)3.69051996
39ethanol metabolic process (GO:0006067)3.66194992
40hypotonic response (GO:0006971)3.65863853
41regulation of cardioblast differentiation (GO:0051890)3.64917380
42sulfation (GO:0051923)3.64297210
43transcytosis (GO:0045056)3.64213290
44antimicrobial humoral response (GO:0019730)3.63984832
45regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.62041648
46ventricular cardiac muscle cell action potential (GO:0086005)3.60193945
47cytoskeletal anchoring at plasma membrane (GO:0007016)3.59089800
48nucleotide-sugar biosynthetic process (GO:0009226)3.57052709
49water homeostasis (GO:0030104)3.55086845
50positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.51878767
51intestinal cholesterol absorption (GO:0030299)3.50708142
52primary alcohol catabolic process (GO:0034310)3.50086269
53protein autoprocessing (GO:0016540)3.49724736
54mesodermal cell differentiation (GO:0048333)3.48390119
55negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.46897172
56citrulline biosynthetic process (GO:0019240)3.46830227
57sulfate transmembrane transport (GO:1902358)3.46116131
58positive regulation of actin filament depolymerization (GO:0030836)3.44096478
59lung secretory cell differentiation (GO:0061140)3.43678895
60proline biosynthetic process (GO:0006561)3.43007050
61terpenoid biosynthetic process (GO:0016114)3.40617792
62atrioventricular valve morphogenesis (GO:0003181)3.35525478
63amyloid precursor protein metabolic process (GO:0042982)3.35073336
64positive regulation of epidermis development (GO:0045684)3.33518102
65negative regulation of cell fate specification (GO:0009996)3.32936164
66positive regulation of protein localization to plasma membrane (GO:1903078)3.32347126
67L-fucose catabolic process (GO:0042355)3.32230972
68fucose catabolic process (GO:0019317)3.32230972
69L-fucose metabolic process (GO:0042354)3.32230972
70vitamin A metabolic process (GO:0006776)3.31448296
71negative regulation of keratinocyte proliferation (GO:0010839)3.31366810
72regulation of pseudopodium assembly (GO:0031272)3.31049874
73regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.28536283
74establishment of apical/basal cell polarity (GO:0035089)3.28198358
75gap junction assembly (GO:0016264)3.27751832
76regulation of keratinocyte differentiation (GO:0045616)3.26507362
77branching involved in salivary gland morphogenesis (GO:0060445)3.23504339
78phosphatidylserine acyl-chain remodeling (GO:0036150)3.21069982
79keratinocyte proliferation (GO:0043616)3.20074582
80regulation of transforming growth factor beta2 production (GO:0032909)3.18409690
81mammary gland alveolus development (GO:0060749)3.15945416
82regulation of apoptotic process involved in morphogenesis (GO:1902337)3.12896726
83negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.12229447
84regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.10025731
85regulation of cholesterol homeostasis (GO:2000188)3.09412283
86epithelial cell differentiation involved in prostate gland development (GO:0060742)3.08639333
87trophectodermal cell differentiation (GO:0001829)3.08317384
88cardiac right ventricle morphogenesis (GO:0003215)3.07977191
89response to water (GO:0009415)3.07226884
90protein O-linked glycosylation (GO:0006493)3.06651596
91regulation of hydrogen peroxide metabolic process (GO:0010310)3.06097407
92hexose catabolic process (GO:0019320)3.05741660
93phosphatidylserine metabolic process (GO:0006658)3.05686218
94citrulline metabolic process (GO:0000052)3.04494011
95branching involved in prostate gland morphogenesis (GO:0060442)3.02850007
96amyloid precursor protein catabolic process (GO:0042987)3.02639569
97semaphorin-plexin signaling pathway (GO:0071526)3.00958641
98mammary gland epithelial cell differentiation (GO:0060644)3.00549291
99nucleotide-sugar metabolic process (GO:0009225)2.99039583
100cell adhesion mediated by integrin (GO:0033627)2.95030345
101cell-substrate junction assembly (GO:0007044)2.93114228
102decidualization (GO:0046697)2.92966873
103surfactant homeostasis (GO:0043129)2.92680969
104glandular epithelial cell differentiation (GO:0002067)2.91352527
105negative regulation of T cell differentiation in thymus (GO:0033085)2.90926927
106face development (GO:0060324)2.90326722
107endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.88905533
108mammary gland epithelial cell proliferation (GO:0033598)2.87148220
109negative regulation of kidney development (GO:0090185)2.86911221
110polarized epithelial cell differentiation (GO:0030859)2.86856783
111diterpenoid biosynthetic process (GO:0016102)2.86791180
112muscle cell migration (GO:0014812)2.85118644
113vitamin transmembrane transport (GO:0035461)2.84880153
114maternal placenta development (GO:0001893)2.84795541
115diol metabolic process (GO:0034311)2.84586737
116thyroid hormone metabolic process (GO:0042403)2.84426445
117angiotensin maturation (GO:0002003)2.82402860
118regulation of interleukin-13 production (GO:0032656)2.82327858
119negative regulation of transcription by competitive promoter binding (GO:0010944)2.80569212
120regulation of water loss via skin (GO:0033561)2.79822655
121cell-cell junction assembly (GO:0007043)2.79217799
122glutathione derivative biosynthetic process (GO:1901687)2.78454286
123glutathione derivative metabolic process (GO:1901685)2.78454286
124sulfate transport (GO:0008272)2.78028232
125digestion (GO:0007586)2.76820189
126columnar/cuboidal epithelial cell development (GO:0002066)2.76791720
127renal system process involved in regulation of blood volume (GO:0001977)2.75141496
128glucose 6-phosphate metabolic process (GO:0051156)2.74908492
129glucose catabolic process (GO:0006007)2.74194341
130bile acid and bile salt transport (GO:0015721)2.73332253
131pentose-phosphate shunt (GO:0006098)2.72918891
132establishment of protein localization to plasma membrane (GO:0090002)2.71900481
133NADH metabolic process (GO:0006734)2.70975447
134positive regulation of epidermal cell differentiation (GO:0045606)2.70586972
135bicarbonate transport (GO:0015701)2.70247424
136striated muscle atrophy (GO:0014891)2.69809871
137norepinephrine metabolic process (GO:0042415)2.68983966
138L-serine transport (GO:0015825)2.68817770
139membrane budding (GO:0006900)2.67212379
140N-glycan processing (GO:0006491)2.67134851
141regulation of cell proliferation involved in kidney development (GO:1901722)2.66561970
142endothelial cell morphogenesis (GO:0001886)2.66510401
143thrombin receptor signaling pathway (GO:0070493)2.66322394
144regulation of Cdc42 GTPase activity (GO:0043088)2.65548973
145focal adhesion assembly (GO:0048041)2.65355549
146cell-substrate adherens junction assembly (GO:0007045)2.65355549
147lung epithelium development (GO:0060428)2.65104441
148regulation of metalloenzyme activity (GO:0048552)2.64565653
149positive regulation of glycoprotein metabolic process (GO:1903020)2.63627205
150phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.62968067
151regulation of podosome assembly (GO:0071801)2.62805170
152regulation of heart rate by cardiac conduction (GO:0086091)2.62523852
153cell communication involved in cardiac conduction (GO:0086065)2.62484025
154GDP-mannose metabolic process (GO:0019673)2.61238306
155protein maturation by protein folding (GO:0022417)2.61222371
156NADPH regeneration (GO:0006740)2.60946184
157* cell differentiation involved in embryonic placenta development (GO:0060706)2.60816596
158regulation of transforming growth factor beta1 production (GO:0032908)2.60392230
159galactose metabolic process (GO:0006012)2.60112591
160regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.59575668
161regulation of interleukin-8 secretion (GO:2000482)2.59273423
162regulation of epidermal cell differentiation (GO:0045604)2.58775348
163sulfur compound transport (GO:0072348)2.58732870
164positive regulation of Cdc42 GTPase activity (GO:0043089)2.57336190
165adherens junction assembly (GO:0034333)2.54703097
166branching involved in labyrinthine layer morphogenesis (GO:0060670)2.53815464
167positive regulation of glycoprotein biosynthetic process (GO:0010560)2.53487899
168morphogenesis of embryonic epithelium (GO:0016331)2.53317205
169skin morphogenesis (GO:0043589)2.52520243
170negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.52457617
171regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.51508429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.68241932
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.25543705
3* CDX2_20551321_ChIP-Seq_CACO-2_Human4.13466591
4* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.89671273
5* SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.53280009
6* GATA4_25053715_ChIP-Seq_YYC3_Human2.99392256
7SOX2_20726797_ChIP-Seq_SW620_Human2.97086321
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.84681964
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.82829197
10* GATA6_25053715_ChIP-Seq_YYC3_Human2.81860253
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.66553118
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.56509248
13KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.31548607
14PPAR_26484153_Chip-Seq_NCI-H1993_Human2.28078214
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.23983804
16* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.20434145
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.18619832
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.15987874
19ZNF263_19887448_ChIP-Seq_K562_Human2.15402754
20FOXO3_23340844_ChIP-Seq_DLD1_Human2.15357419
21RACK7_27058665_Chip-Seq_MCF-7_Human2.04099657
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.99035045
23* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.98979741
24* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.98979741
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98078046
26KLF5_25053715_ChIP-Seq_YYC3_Human1.96401661
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91176954
28CLOCK_20551151_ChIP-Seq_293T_Human1.89504310
29ATF3_27146783_Chip-Seq_COLON_Human1.87674028
30KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.87459018
31* RUNX1_27514584_Chip-Seq_MCF-7_Human1.86638121
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.83964186
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80023464
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78326941
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.76346230
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76097570
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.75752308
38* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.74946397
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68901533
40* ESR1_20079471_ChIP-ChIP_T-47D_Human1.68635304
41* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68264373
42* TRIM28_21343339_ChIP-Seq_HEK293_Human1.67840928
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.64830080
44FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.62575461
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.61260568
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57860527
47AR_21909140_ChIP-Seq_LNCAP_Human1.57545012
48* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55433356
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53003892
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52492109
51* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50468438
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47884151
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45616725
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44790746
55* GATA3_24758297_ChIP-Seq_MCF-7_Human1.40794793
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37113936
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.36835846
58P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35360627
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.33436732
60HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30014646
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28654099
62* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27299451
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26535222
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.24381239
65* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22801135
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19639845
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.19196722
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18974823
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18440823
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17923485
71TCF4_18268006_ChIP-ChIP_LS174T_Human1.17196033
72* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16274564
73* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15747039
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.15640627
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14703911
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14358325
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12882187
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.11251831
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10981430
80* SMC4_20622854_ChIP-Seq_HELA_Human1.10408944
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08323104
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07947974
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07940022
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05534183
85P68_20966046_ChIP-Seq_HELA_Human1.04415195
86* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04166871
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03755734
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03391554
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02278402
90CREB1_26743006_Chip-Seq_LNCaP_Human1.02231554
91TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.01326746
92AHR_22903824_ChIP-Seq_MCF-7_Human1.01079985
93ELF5_23300383_ChIP-Seq_T47D_Human1.00453160
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99720670
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99553307
96LXR_22292898_ChIP-Seq_THP-1_Human0.98500722
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.98416786
98ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98091727
99FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97351553
100OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95142776
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94984850
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.94021952
103ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93993306
104FOXA2_19822575_ChIP-Seq_HepG2_Human0.93971601
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93544898
106* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93233982
107NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91932021
108* CJUN_26792858_Chip-Seq_BT549_Human0.91729877
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91598878
110UBF1/2_26484160_Chip-Seq_HMECs_Human0.90844566
111NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90027972
112TCF7_22412390_ChIP-Seq_EML_Mouse0.89803537
113NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89261760
114FOXA1_25552417_ChIP-Seq_VCAP_Human0.88830943
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88306497
116KDM5A_27292631_Chip-Seq_BREAST_Human0.88237138
117* GATA2_19941826_ChIP-Seq_K562_Human0.86568227
118* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85999691
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84916692
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84260794
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82336170
122* TP63_22573176_ChIP-Seq_HFKS_Human0.82053872
123CHD1_26751641_Chip-Seq_LNCaP_Human0.80625274
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79940812
125HNF4A_19822575_ChIP-Seq_HepG2_Human0.78200325
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77801905
127ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77487038
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75663089
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75216791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.63622689
2MP0000537_abnormal_urethra_morphology4.80063210
3MP0008004_abnormal_stomach_pH3.94593310
4MP0000462_abnormal_digestive_system3.71006757
5MP0001873_stomach_inflammation3.26726394
6MP0003866_abnormal_defecation3.16069595
7MP0001666_abnormal_nutrient_absorption3.09456669
8MP0010352_gastrointestinal_tract_polyps2.90591494
9* MP0004264_abnormal_extraembryonic_tissu2.75506740
10MP0010155_abnormal_intestine_physiology2.69102340
11MP0003300_gastrointestinal_ulcer2.56908549
12MP0001663_abnormal_digestive_system2.53596332
13MP0001664_abnormal_digestion2.53259759
14MP0003705_abnormal_hypodermis_morpholog2.52679304
15MP0006054_spinal_hemorrhage2.46643084
16MP0005381_digestive/alimentary_phenotyp2.44814213
17MP0003283_abnormal_digestive_organ2.32841276
18MP0000477_abnormal_intestine_morphology2.31563040
19MP0000490_abnormal_crypts_of2.31298259
20MP0000579_abnormal_nail_morphology2.29898330
21MP0001849_ear_inflammation2.11420237
22MP0005360_urolithiasis2.08387602
23MP0002796_impaired_skin_barrier2.01070559
24MP0010678_abnormal_skin_adnexa2.00354030
25MP0010030_abnormal_orbit_morphology1.86395377
26MP0005451_abnormal_body_composition1.79005093
27MP0003453_abnormal_keratinocyte_physiol1.78839286
28MP0000516_abnormal_urinary_system1.70581894
29MP0005367_renal/urinary_system_phenotyp1.70581894
30MP0003566_abnormal_cell_adhesion1.69627071
31MP0000470_abnormal_stomach_morphology1.63449977
32MP0003315_abnormal_perineum_morphology1.60392739
33MP0001346_abnormal_lacrimal_gland1.59600985
34MP0000538_abnormal_urinary_bladder1.58760257
35MP0003806_abnormal_nucleotide_metabolis1.48503799
36MP0005085_abnormal_gallbladder_physiolo1.47471571
37MP0005501_abnormal_skin_physiology1.45465145
38MP0005167_abnormal_blood-brain_barrier1.42822043
39MP0000427_abnormal_hair_cycle1.41593657
40MP0008260_abnormal_autophagy1.39733238
41MP0002098_abnormal_vibrissa_morphology1.36648594
42MP0001216_abnormal_epidermal_layer1.32013645
43MP0000467_abnormal_esophagus_morphology1.29977057
44MP0002060_abnormal_skin_morphology1.27918905
45MP0008875_abnormal_xenobiotic_pharmacok1.27412379
46MP0009384_cardiac_valve_regurgitation1.24767544
47MP0004947_skin_inflammation1.23980975
48MP0005377_hearing/vestibular/ear_phenot1.21922968
49MP0003878_abnormal_ear_physiology1.21922968
50MP0005248_abnormal_Harderian_gland1.21012627
51MP0009643_abnormal_urine_homeostasis1.16872427
52MP0005409_darkened_coat_color1.15053708
53MP0005187_abnormal_penis_morphology1.11063280
54MP0002254_reproductive_system_inflammat1.10615334
55MP0009931_abnormal_skin_appearance1.10067221
56MP0009053_abnormal_anal_canal1.09795636
57MP0002234_abnormal_pharynx_morphology1.09563502
58MP0001765_abnormal_ion_homeostasis1.09175863
59MP0004272_abnormal_basement_membrane1.07746057
60MP0004381_abnormal_hair_follicle1.07617844
61MP0005166_decreased_susceptibility_to1.07608001
62MP0003252_abnormal_bile_duct1.06784516
63MP0005058_abnormal_lysosome_morphology1.05439207
64MP0005408_hypopigmentation1.04205856
65MP0003183_abnormal_peptide_metabolism1.02165699
66MP0001727_abnormal_embryo_implantation1.02122295
67MP0003123_paternal_imprinting1.00614237
68MP0004019_abnormal_vitamin_homeostasis1.00121189
69MP0005310_abnormal_salivary_gland0.99097697
70MP0001881_abnormal_mammary_gland0.98337041
71MP0004782_abnormal_surfactant_physiolog0.95892651
72MP0005023_abnormal_wound_healing0.95402986
73MP0000465_gastrointestinal_hemorrhage0.95251618
74MP0004185_abnormal_adipocyte_glucose0.95215806
75MP0002139_abnormal_hepatobiliary_system0.94871219
76MP0009379_abnormal_foot_pigmentation0.94655662
77MP0003638_abnormal_response/metabolism_0.91940514
78MP0010771_integument_phenotype0.90758718
79MP0002909_abnormal_adrenal_gland0.90536315
80MP0000762_abnormal_tongue_morphology0.87800900
81MP0002138_abnormal_hepatobiliary_system0.87514812
82MP0000383_abnormal_hair_follicle0.87102698
83MP0005165_increased_susceptibility_to0.86399894
84MP0005365_abnormal_bile_salt0.85221463
85MP0002249_abnormal_larynx_morphology0.83137221
86MP0000627_abnormal_mammary_gland0.82869537
87MP0005636_abnormal_mineral_homeostasis0.82781354
88MP0005083_abnormal_biliary_tract0.82680279
89MP0004233_abnormal_muscle_weight0.82225646
90MP0005275_abnormal_skin_tensile0.81493129
91MP0003693_abnormal_embryo_hatching0.81056771
92MP0000647_abnormal_sebaceous_gland0.81039569
93MP0004858_abnormal_nervous_system0.80367656
94MP0000367_abnormal_coat/_hair0.80291929
95MP0003119_abnormal_digestive_system0.80184545
96MP0002877_abnormal_melanocyte_morpholog0.79932883
97MP0003045_fibrosis0.79422998
98MP0000613_abnormal_salivary_gland0.77899102
99MP0000377_abnormal_hair_follicle0.77600486
100MP0002282_abnormal_trachea_morphology0.77255476
101* MP0003936_abnormal_reproductive_system0.74471914
102MP0010329_abnormal_lipoprotein_level0.73959945
103MP0000566_synostosis0.73480530
104MP0002089_abnormal_postnatal_growth/wei0.72832975
105MP0005257_abnormal_intraocular_pressure0.72709670
106MP0002136_abnormal_kidney_physiology0.72105240
107MP0002896_abnormal_bone_mineralization0.71617839
108MP0005666_abnormal_adipose_tissue0.70141893
109MP0001243_abnormal_dermal_layer0.69708692
110MP0005076_abnormal_cell_differentiation0.68165669
111MP0000534_abnormal_ureter_morphology0.67746398
112MP0004043_abnormal_pH_regulation0.67055791
113MP0001756_abnormal_urination0.67047318
114MP0003941_abnormal_skin_development0.66344257
115MP0002166_altered_tumor_susceptibility0.66183865
116* MP0002086_abnormal_extraembryonic_tissu0.65887851
117MP0002822_catalepsy0.65320293
118MP0004484_altered_response_of0.65232270
119MP0001340_abnormal_eyelid_morphology0.62801476
120MP0003191_abnormal_cellular_cholesterol0.62701500
121MP0009780_abnormal_chondrocyte_physiolo0.62547030
122MP0000681_abnormal_thyroid_gland0.61818451
123MP0000003_abnormal_adipose_tissue0.60934541
124MP0003091_abnormal_cell_migration0.58300387
125MP0004957_abnormal_blastocyst_morpholog0.58208190
126MP0000678_abnormal_parathyroid_gland0.57171198
127MP0009672_abnormal_birth_weight0.56580605
128MP0009840_abnormal_foam_cell0.56186484
129MP0002006_tumorigenesis0.55633372
130MP0000858_altered_metastatic_potential0.52754802
131MP0003075_altered_response_to0.51985470
132MP0003115_abnormal_respiratory_system0.51774593

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)7.35716585
2Ileus (HP:0002595)5.49953114
3Onycholysis (HP:0001806)5.03245885
4Micronodular cirrhosis (HP:0001413)4.72465419
5Abnormality of the 1st metacarpal (HP:0010009)4.42932589
6Milia (HP:0001056)4.41717710
7Pustule (HP:0200039)4.32891587
8Flat acetabular roof (HP:0003180)4.15305384
9Fragile nails (HP:0001808)4.11245487
10Atrophic scars (HP:0001075)4.06113903
11Abdominal distention (HP:0003270)4.03729294
12Pili torti (HP:0003777)4.00382793
13Distal lower limb muscle weakness (HP:0009053)3.96092079
14Hyperactive renin-angiotensin system (HP:0000841)3.58866133
15Abnormal tarsal ossification (HP:0008369)3.46066844
16Plantar hyperkeratosis (HP:0007556)3.39046323
17Abnormality of nail color (HP:0100643)3.33282481
18Woolly hair (HP:0002224)3.31298463
19Abnormality of the 2nd finger (HP:0004100)3.28635414
20Ureteral stenosis (HP:0000071)3.20886959
21Abnormality of the distal phalanx of the thumb (HP:0009617)3.19567264
22Short nail (HP:0001799)3.13282846
23Abnormality of the gastric mucosa (HP:0004295)3.08659584
24Abnormality of carpal bone ossification (HP:0006257)3.07841768
25Esophageal varix (HP:0002040)3.06096970
26Septate vagina (HP:0001153)3.04405339
27Focal segmental glomerulosclerosis (HP:0000097)3.01515811
28Fragile skin (HP:0001030)3.01268521
29Short phalanx of the thumb (HP:0009660)3.01020659
30Ureteral obstruction (HP:0006000)2.95392091
31Biliary tract neoplasm (HP:0100574)2.92272978
32Curly hair (HP:0002212)2.89479360
33Concave nail (HP:0001598)2.88030074
34Abnormal foot bone ossification (HP:0010675)2.86309813
35Rectal prolapse (HP:0002035)2.85492189
36Chronic bronchitis (HP:0004469)2.83841446
37Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.81093942
38Short 1st metacarpal (HP:0010034)2.81093942
39Sparse eyelashes (HP:0000653)2.80850120
40Malnutrition (HP:0004395)2.80256374
41Villous atrophy (HP:0011473)2.76321243
42Abnormality of small intestinal villus morphology (HP:0011472)2.76321243
43Amelogenesis imperfecta (HP:0000705)2.69837857
44Progressive sensorineural hearing impairment (HP:0000408)2.68252164
45Palpitations (HP:0001962)2.66046844
46Abnormality of the proximal phalanges of the hand (HP:0009834)2.64307257
47Glomerulosclerosis (HP:0000096)2.63294349
48Abnormality of chloride homeostasis (HP:0011422)2.63193346
49Mildly elevated creatine phosphokinase (HP:0008180)2.63163561
50Short hallux (HP:0010109)2.62931097
51Ventricular fibrillation (HP:0001663)2.62223344
52Upper limb amyotrophy (HP:0009129)2.59191048
53Distal upper limb amyotrophy (HP:0007149)2.59191048
54Lip pit (HP:0100267)2.58249160
55Gout (HP:0001997)2.57592918
56Abnormal biliary tract morphology (HP:0012440)2.56600643
57Abnormal ossification of hand bones (HP:0005921)2.52298527
58Distal lower limb amyotrophy (HP:0008944)2.52235834
59Cupped ribs (HP:0000887)2.51898573
60Syncope (HP:0001279)2.50230966
61Congenital sensorineural hearing impairment (HP:0008527)2.50022499
62Ankyloglossia (HP:0010296)2.47795839
63Selective tooth agenesis (HP:0001592)2.47140103
64Sparse lateral eyebrow (HP:0005338)2.46921476
65Abnormal hair laboratory examination (HP:0003328)2.45757291
66Trismus (HP:0000211)2.44917463
67J-shaped sella turcica (HP:0002680)2.44519669
68Cervical subluxation (HP:0003308)2.43566235
69Gastrointestinal dysmotility (HP:0002579)2.43354341
70Symphalangism affecting the phalanges of the hand (HP:0009773)2.42558489
71Abnormality of the dental root (HP:0006486)2.41634270
72Taurodontia (HP:0000679)2.41634270
73Abnormality of permanent molar morphology (HP:0011071)2.41634270
74Broad face (HP:0000283)2.40250503
75Alopecia of scalp (HP:0002293)2.39975318
76Hypoplasia of dental enamel (HP:0006297)2.38836272
77Diaphragmatic weakness (HP:0009113)2.38531367
78Aplasia/Hypoplasia of the hallux (HP:0008362)2.37910202
79Aortic aneurysm (HP:0004942)2.37618965
80Popliteal pterygium (HP:0009756)2.36269090
81Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.34483985
82Subacute progressive viral hepatitis (HP:0006572)2.34083958
83Hyperacusis (HP:0010780)2.33051745
84Advanced eruption of teeth (HP:0006288)2.31929021
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31922265
86Congenital ichthyosiform erythroderma (HP:0007431)2.29675656
87Acanthosis nigricans (HP:0000956)2.27985748
88Metabolic alkalosis (HP:0200114)2.25958177
89Uterine neoplasm (HP:0010784)2.24683021
90Abnormal hand bone ossification (HP:0010660)2.24676100
91Ridged nail (HP:0001807)2.24030717
92Goiter (HP:0000853)2.22845060
93Nail dystrophy (HP:0008404)2.22438958
94Interstitial pulmonary disease (HP:0006530)2.22038129
95Cheilitis (HP:0100825)2.20012608
96Thin bony cortex (HP:0002753)2.18942299
97Progressive hearing impairment (HP:0001730)2.18064029
98Abnormality of molar morphology (HP:0011070)2.18037585
99Abnormality of molar (HP:0011077)2.18037585
100Esophageal atresia (HP:0002032)2.15466694
101Hypotrichosis (HP:0001006)2.15175701
102Vertebral clefting (HP:0008428)2.14922219
103Abnormality of monocarboxylic acid metabolism (HP:0010996)2.14886239
104Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13941407
105Glucose intolerance (HP:0000833)2.13286366
106Cardiovascular calcification (HP:0011915)2.13282580
107Dehydration (HP:0001944)2.13234545
108Abnormality of the distal phalanges of the toes (HP:0010182)2.12898742
109Ventricular tachycardia (HP:0004756)2.06817724
110Down-sloping shoulders (HP:0200021)2.06753579
111Abnormal cartilage morphology (HP:0002763)2.06575496
112Renal salt wasting (HP:0000127)2.05424613
113Hoarse voice (HP:0001609)2.04859510
114Abnormality of the dental pulp (HP:0006479)2.03959350
115Vertebral hypoplasia (HP:0008417)2.03537721
116Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.03537721
117Abnormality of the umbilical cord (HP:0010881)2.03236755
118Decreased circulating renin level (HP:0003351)2.00808841
119Neoplasm of the rectum (HP:0100743)2.00758656
120Hyperparathyroidism (HP:0000843)2.00545077
121Abnormality of oral frenula (HP:0000190)1.99535285
122Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.99154764
123Flattened epiphyses (HP:0003071)1.97585742
124Abnormality of renin-angiotensin system (HP:0000847)1.96636639
125Stridor (HP:0010307)1.95591543
126Vascular calcification (HP:0004934)1.94117109
127Abnormal blistering of the skin (HP:0008066)1.93803473
128Hypokinesia (HP:0002375)1.93040751
129Axonal loss (HP:0003447)1.92930163
130Abnormality of proline metabolism (HP:0010907)1.92470227
131Hydroxyprolinuria (HP:0003080)1.92470227
132Deviation of the thumb (HP:0009603)1.91107730
133Neoplasm of the small intestine (HP:0100833)1.90969421
134Abnormalities of placenta or umbilical cord (HP:0001194)1.90770767
135Hand muscle atrophy (HP:0009130)1.90187391
136Short middle phalanx of finger (HP:0005819)1.88925463
137Palmoplantar hyperkeratosis (HP:0000972)1.87521494
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87318247
139Pterygium (HP:0001059)1.87086011
140Spinal cord compression (HP:0002176)1.86782825
141Germ cell neoplasia (HP:0100728)1.86627226
142Asymmetry of the thorax (HP:0001555)1.85679843
143Thick nail (HP:0001805)1.85408168
144Abnormality of the middle phalanges of the toes (HP:0010183)1.84944669
145Chronic diarrhea (HP:0002028)1.84613479
146Deep venous thrombosis (HP:0002625)1.84308716
147Abnormal glucose tolerance (HP:0001952)1.83699676
148Abnormal vertebral ossification (HP:0100569)1.83449342
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.82375148
150Osteolytic defects of the hand bones (HP:0009699)1.82375148
151Periodontitis (HP:0000704)1.82201061
152Natal tooth (HP:0000695)1.80781355
153Gastrointestinal carcinoma (HP:0002672)1.79926131
154Nasal polyposis (HP:0100582)1.78887148
155Breast carcinoma (HP:0003002)1.77263300
156Microretrognathia (HP:0000308)1.76850232
157Abnormality of the salivary glands (HP:0010286)1.75093632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.26628081
2EPHA25.20056238
3MST1R4.19109885
4FRK3.67825671
5MAP2K23.56100391
6LMTK23.47207740
7TESK12.45685117
8NME22.40337967
9PIK3CA2.28527748
10PTK62.28217967
11PRKG22.18116083
12RIPK12.17633464
13EPHB22.15942007
14MAP3K22.12220455
15SMG12.00521310
16MET1.89414834
17MYLK1.86330199
18FER1.86174302
19PAK41.80783956
20PKN21.68194404
21PBK1.58704791
22ERN11.57011632
23MAP2K11.56986090
24RPS6KB21.56690977
25PTK21.56318667
26STK391.56101984
27STK101.54633390
28LRRK21.52194126
29TRIB31.51795656
30NME11.47605378
31IRAK31.42732981
32LATS11.42201595
33DMPK1.33247108
34ERBB41.31505216
35NUAK11.30459470
36DDR21.28123279
37SIK31.27013954
38LIMK11.22509330
39PRKCI1.21259230
40MUSK1.17526775
41EIF2AK11.17487608
42EPHB11.13908153
43EEF2K1.09268309
44TTN1.04106968
45KSR21.03487635
46MATK1.01332627
47ERBB21.00396040
48MAP3K30.99367934
49MAP3K80.98367918
50FGFR40.95944577
51NEK60.94504064
52MAP3K70.93012468
53SIK10.91621111
54VRK20.91056019
55LATS20.88880952
56TAOK10.88763980
57MAPK150.85112232
58TAOK30.82000692
59SCYL20.78794993
60CAMK2D0.75242150
61GRK60.71532013
62MAP2K60.70067116
63ARAF0.69276273
64STK38L0.67502493
65TRPM70.65585750
66CDK70.65217560
67OXSR10.64615172
68MAP3K120.62584040
69MAP3K100.61950257
70CAMK2B0.61241405
71PDGFRA0.61123752
72TRIM280.60659576
73CDK120.57067556
74PAK10.56765494
75AURKB0.55636465
76CAMK2G0.55633958
77CHUK0.54878493
78BMX0.54649660
79BUB10.53000800
80MAPKAPK30.52319541
81MTOR0.52061210
82PAK20.51865498
83PIM20.51778338
84MAP3K10.51130302
85CDK80.49878286
86STK380.49695830
87PAK30.49074027
88NTRK10.48928957
89DAPK10.48824635
90ROCK10.47846400
91NEK10.47524640
92CDK60.47319995
93MAP3K90.46160443
94STK30.43629218
95PDGFRB0.43566973
96NEK90.42410523
97PDPK10.41583285
98AKT20.40646559
99TSSK60.40628371
100CSK0.40273267
101ROCK20.39311756
102DAPK30.39144680
103TESK20.38651752
104ZAP700.36172665
105ILK0.35453101
106WNK40.34260188
107TBK10.34114384
108ABL20.34108811
109NEK20.33717792
110* SRC0.33644179
111FGFR10.31796063
112RET0.31277443
113TTK0.30551339
114PRKAA20.30033837
115RPS6KA20.26907239
116MAP3K60.26377842
117ICK0.24842706
118AKT30.24636445
119MAP3K110.23632690
120RPS6KA40.23512622
121PDK20.23390017
122PRKD20.22923890
123MAPKAPK20.22473578
124STK240.22169118
125PIK3CG0.22011051
126CDC42BPA0.21308391
127CDK90.21157540
128EGFR0.20620466
129DYRK1B0.20363712
130PRKCA0.20024984
131FYN0.19510165
132BRSK10.19485830
133GSK3A0.18646985
134MELK0.18573022
135FLT30.18462834
136TGFBR20.18116724
137PRKCD0.16472362

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.53876299
2Mineral absorption_Homo sapiens_hsa049783.16950317
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.09206240
4Fat digestion and absorption_Homo sapiens_hsa049752.90803801
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.84471237
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.67096168
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48447718
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.47560988
9Tight junction_Homo sapiens_hsa045302.21842314
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.06973478
11Fructose and mannose metabolism_Homo sapiens_hsa000512.01524900
12Histidine metabolism_Homo sapiens_hsa003401.97905543
13Proteasome_Homo sapiens_hsa030501.92489717
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85421267
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84865716
16Glutathione metabolism_Homo sapiens_hsa004801.78561230
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76545997
18Bladder cancer_Homo sapiens_hsa052191.71286586
19Adherens junction_Homo sapiens_hsa045201.69548810
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.62460360
21Galactose metabolism_Homo sapiens_hsa000521.60609821
22Other glycan degradation_Homo sapiens_hsa005111.59275411
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.54354504
24Thyroid cancer_Homo sapiens_hsa052161.53009399
25Chemical carcinogenesis_Homo sapiens_hsa052041.52178925
26Bile secretion_Homo sapiens_hsa049761.52087800
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.39942182
28Tyrosine metabolism_Homo sapiens_hsa003501.36300351
29Biosynthesis of amino acids_Homo sapiens_hsa012301.35914446
30Renin-angiotensin system_Homo sapiens_hsa046141.35783261
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.32337838
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28277850
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27749504
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25985887
35Fatty acid degradation_Homo sapiens_hsa000711.25467155
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19958611
37Pancreatic secretion_Homo sapiens_hsa049721.19384641
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14351305
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12650322
40Thyroid hormone synthesis_Homo sapiens_hsa049181.12132706
41Salmonella infection_Homo sapiens_hsa051321.11934018
42ECM-receptor interaction_Homo sapiens_hsa045121.11150375
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11042010
44Caffeine metabolism_Homo sapiens_hsa002321.05474798
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05380014
46Fatty acid elongation_Homo sapiens_hsa000621.04396906
47Linoleic acid metabolism_Homo sapiens_hsa005911.03328397
48Gastric acid secretion_Homo sapiens_hsa049711.01226549
49Protein digestion and absorption_Homo sapiens_hsa049741.00663817
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95880819
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95756810
52Pentose phosphate pathway_Homo sapiens_hsa000300.95225291
53Glycerolipid metabolism_Homo sapiens_hsa005610.93235663
54Tryptophan metabolism_Homo sapiens_hsa003800.93019487
55Small cell lung cancer_Homo sapiens_hsa052220.88144587
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87821357
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.87537803
58Vitamin digestion and absorption_Homo sapiens_hsa049770.87292183
59Starch and sucrose metabolism_Homo sapiens_hsa005000.86276896
60Pyruvate metabolism_Homo sapiens_hsa006200.85731716
61Hepatitis C_Homo sapiens_hsa051600.84689024
62Carbon metabolism_Homo sapiens_hsa012000.82729001
63N-Glycan biosynthesis_Homo sapiens_hsa005100.82123180
64Endocytosis_Homo sapiens_hsa041440.81058747
65Nitrogen metabolism_Homo sapiens_hsa009100.80821194
66Pancreatic cancer_Homo sapiens_hsa052120.80293040
67Notch signaling pathway_Homo sapiens_hsa043300.80206458
68ErbB signaling pathway_Homo sapiens_hsa040120.77898575
69Vibrio cholerae infection_Homo sapiens_hsa051100.77558961
70Insulin signaling pathway_Homo sapiens_hsa049100.76338532
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76263594
72Hippo signaling pathway_Homo sapiens_hsa043900.75985121
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73679336
74Acute myeloid leukemia_Homo sapiens_hsa052210.71237503
75Proteoglycans in cancer_Homo sapiens_hsa052050.71179818
76Focal adhesion_Homo sapiens_hsa045100.70398518
77Renal cell carcinoma_Homo sapiens_hsa052110.70133409
78Amoebiasis_Homo sapiens_hsa051460.69710081
79Lysosome_Homo sapiens_hsa041420.69463274
80Toxoplasmosis_Homo sapiens_hsa051450.68755553
81AMPK signaling pathway_Homo sapiens_hsa041520.68390695
82PPAR signaling pathway_Homo sapiens_hsa033200.66859735
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66432508
84Endometrial cancer_Homo sapiens_hsa052130.65926764
85Arachidonic acid metabolism_Homo sapiens_hsa005900.64892519
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61954522
87Arginine and proline metabolism_Homo sapiens_hsa003300.61461323
88Insulin resistance_Homo sapiens_hsa049310.59519922
89Axon guidance_Homo sapiens_hsa043600.58264864
90Salivary secretion_Homo sapiens_hsa049700.56451727
91Retinol metabolism_Homo sapiens_hsa008300.54800755
92Steroid biosynthesis_Homo sapiens_hsa001000.53975452
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52223561
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51839424
95Oxidative phosphorylation_Homo sapiens_hsa001900.51118759
96beta-Alanine metabolism_Homo sapiens_hsa004100.50608201
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48219738
98Alzheimers disease_Homo sapiens_hsa050100.47392099
99Inositol phosphate metabolism_Homo sapiens_hsa005620.46899283
100Ether lipid metabolism_Homo sapiens_hsa005650.46614444
101Shigellosis_Homo sapiens_hsa051310.46248733
102Butanoate metabolism_Homo sapiens_hsa006500.45849749
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42593738
104Non-small cell lung cancer_Homo sapiens_hsa052230.41221834
105Pertussis_Homo sapiens_hsa051330.41077721
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40922482
107Sulfur relay system_Homo sapiens_hsa041220.40479550
108Folate biosynthesis_Homo sapiens_hsa007900.40469418
109Base excision repair_Homo sapiens_hsa034100.40062542
110Prostate cancer_Homo sapiens_hsa052150.39631419
111Metabolic pathways_Homo sapiens_hsa011000.37111914
112Apoptosis_Homo sapiens_hsa042100.36904773
113VEGF signaling pathway_Homo sapiens_hsa043700.35945896
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.35703037
115ABC transporters_Homo sapiens_hsa020100.35349274
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35229741
117Sphingolipid metabolism_Homo sapiens_hsa006000.34487198
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34233181
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.33123694
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32734830
121African trypanosomiasis_Homo sapiens_hsa051430.32373749
122Chronic myeloid leukemia_Homo sapiens_hsa052200.31802325
123Prolactin signaling pathway_Homo sapiens_hsa049170.31449669
124Pyrimidine metabolism_Homo sapiens_hsa002400.31344629
125Phenylalanine metabolism_Homo sapiens_hsa003600.31205704
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28938264
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28394316
128Legionellosis_Homo sapiens_hsa051340.28338224
129HIF-1 signaling pathway_Homo sapiens_hsa040660.27734295
130Parkinsons disease_Homo sapiens_hsa050120.27661321
131Arginine biosynthesis_Homo sapiens_hsa002200.27375625
132Influenza A_Homo sapiens_hsa051640.26892493
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25940257
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.25915121
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25354579

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