KRT19P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.66605125
2Golgi transport vesicle coating (GO:0048200)5.17738113
3COPI coating of Golgi vesicle (GO:0048205)5.17738113
4bundle of His cell to Purkinje myocyte communication (GO:0086069)5.08917483
5protein maturation by protein folding (GO:0022417)4.90630199
6hemidesmosome assembly (GO:0031581)4.82190156
7artery smooth muscle contraction (GO:0014824)4.73057287
8establishment of integrated proviral latency (GO:0075713)4.35555898
9positive regulation of epidermal cell differentiation (GO:0045606)4.26849526
10interferon-gamma secretion (GO:0072643)4.26183941
11establishment of viral latency (GO:0019043)4.21037129
12negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.14487012
13tonic smooth muscle contraction (GO:0014820)4.01126940
14nuclear envelope reassembly (GO:0031468)3.96848253
15mitotic nuclear envelope reassembly (GO:0007084)3.96848253
16prostaglandin biosynthetic process (GO:0001516)3.91551759
17prostanoid biosynthetic process (GO:0046457)3.91551759
18negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.89727787
19positive regulation of actin filament depolymerization (GO:0030836)3.84332242
20hepatocyte apoptotic process (GO:0097284)3.80929434
21regulation of water loss via skin (GO:0033561)3.78549193
22xenobiotic catabolic process (GO:0042178)3.68803481
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.62179545
24regulation of metalloenzyme activity (GO:0048552)3.58114813
25proteasome assembly (GO:0043248)3.57518217
26GDP-mannose metabolic process (GO:0019673)3.52334744
27establishment of skin barrier (GO:0061436)3.49135156
28protein retention in ER lumen (GO:0006621)3.48228456
29membrane raft organization (GO:0031579)3.44175418
30positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.42122378
31NADH metabolic process (GO:0006734)3.36815417
32daunorubicin metabolic process (GO:0044597)3.36811189
33polyketide metabolic process (GO:0030638)3.36811189
34doxorubicin metabolic process (GO:0044598)3.36811189
35positive regulation of Cdc42 GTPase activity (GO:0043089)3.27854727
36regulation of cellular amino acid metabolic process (GO:0006521)3.27496354
37membrane budding (GO:0006900)3.26133799
38muscle cell migration (GO:0014812)3.25321778
39regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.23377625
40galactose catabolic process (GO:0019388)3.18767152
41glucose 6-phosphate metabolic process (GO:0051156)3.17175794
42negative regulation of keratinocyte proliferation (GO:0010839)3.16378192
43prostanoid metabolic process (GO:0006692)3.14512379
44prostaglandin metabolic process (GO:0006693)3.14512379
45regulation of cell proliferation involved in kidney development (GO:1901722)3.13970698
46keratinocyte development (GO:0003334)3.13802824
47negative regulation of kidney development (GO:0090185)3.10648006
48positive regulation of pseudopodium assembly (GO:0031274)3.10262577
49positive regulation of epidermis development (GO:0045684)3.08350270
50ribosome assembly (GO:0042255)3.05109199
51calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.02384824
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00025116
53mesonephros development (GO:0001823)2.99139823
54pentose-phosphate shunt (GO:0006098)2.95468254
55aminoglycoside antibiotic metabolic process (GO:0030647)2.93930633
56glucose catabolic process (GO:0006007)2.93334207
57retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.92632780
58multicellular organismal water homeostasis (GO:0050891)2.90439317
59endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.90180254
60positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87401503
61macrophage chemotaxis (GO:0048246)2.85564764
62DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85512376
63hepatocyte differentiation (GO:0070365)2.85098698
64inositol phosphate-mediated signaling (GO:0048016)2.83673129
65diterpenoid biosynthetic process (GO:0016102)2.81027430
66negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.80390822
67NADPH regeneration (GO:0006740)2.79322607
68signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79129041
69intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79129041
70nucleotide-sugar biosynthetic process (GO:0009226)2.78799257
71branching involved in mammary gland duct morphogenesis (GO:0060444)2.78050958
72positive regulation of keratinocyte differentiation (GO:0045618)2.76641260
73type B pancreatic cell proliferation (GO:0044342)2.76610113
74negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75810440
75negative regulation of ligase activity (GO:0051352)2.75810440
76cell differentiation involved in embryonic placenta development (GO:0060706)2.74504198
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73701403
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73701403
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73701403
80signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73237407
81signal transduction involved in DNA damage checkpoint (GO:0072422)2.73237407
82galactose metabolic process (GO:0006012)2.71813464
83regulation of pseudopodium assembly (GO:0031272)2.69658773
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.68346108
85endothelial tube morphogenesis (GO:0061154)2.68259784
86morphogenesis of an endothelium (GO:0003159)2.68259784
87embryonic skeletal joint morphogenesis (GO:0060272)2.66033490
88proline biosynthetic process (GO:0006561)2.65864841
89signal transduction involved in cell cycle checkpoint (GO:0072395)2.65221399
90epithelial cell-cell adhesion (GO:0090136)2.63737542
91establishment of protein localization to plasma membrane (GO:0090002)2.60398495
92actin filament depolymerization (GO:0030042)2.59377741
93negative regulation of chondrocyte differentiation (GO:0032331)2.58943881
94intestinal epithelial cell development (GO:0060576)2.58678827
95negative regulation of cell fate specification (GO:0009996)2.58425071
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.58132253
97regulation of cardioblast differentiation (GO:0051890)2.57287606
98barbed-end actin filament capping (GO:0051016)2.54513922
99extracellular fibril organization (GO:0043206)2.53380395
100cellular copper ion homeostasis (GO:0006878)2.51692540

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.02777778
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.55976134
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.45669674
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.30618237
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.77099396
6HIF1A_21447827_ChIP-Seq_MCF-7_Human2.76301792
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68863355
8ZNF263_19887448_ChIP-Seq_K562_Human2.64379738
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.63698055
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.45521259
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18213479
12RACK7_27058665_Chip-Seq_MCF-7_Human2.18074702
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13529207
14KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.08560766
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.05432670
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98453681
17ATF3_27146783_Chip-Seq_COLON_Human1.97331926
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.97084067
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.97084067
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91336823
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91102156
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.85222630
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.83122580
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77095455
25KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.75778477
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75755507
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.75305989
28ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.69544029
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67475800
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.64019075
31SOX2_20726797_ChIP-Seq_SW620_Human1.63136391
32GATA6_25053715_ChIP-Seq_YYC3_Human1.61626974
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61440372
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61111728
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.59519656
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57541112
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.56906579
38AR_21909140_ChIP-Seq_LNCAP_Human1.55724773
39DCP1A_22483619_ChIP-Seq_HELA_Human1.54794258
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54353296
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.53470185
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52821279
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51651169
44GATA3_24758297_ChIP-Seq_MCF-7_Human1.51048813
45HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.48270349
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48240967
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47205533
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47041541
49ELF5_23300383_ChIP-Seq_T47D_Human1.45724994
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.44451058
51P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38744955
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37235517
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36688854
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.35974816
55CLOCK_20551151_ChIP-Seq_293T_Human1.35876529
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33786624
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33217450
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32350043
59GABP_19822575_ChIP-Seq_HepG2_Human1.31589609
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30332802
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30068236
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29958787
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28523404
64EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28272987
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25913764
66XRN2_22483619_ChIP-Seq_HELA_Human1.25865883
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24293064
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23393237
69GATA4_25053715_ChIP-Seq_YYC3_Human1.22382757
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21209700
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20771890
72FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19939131
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19641666
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19508480
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16727365
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16325237
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14927006
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14366584
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12690730
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12458580
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.12399365
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11472136
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11274621
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10285687
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.09101688
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.08990557
87LXR_22292898_ChIP-Seq_THP-1_Human1.08635906
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07593358
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07554700
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07399799
91KDM5A_27292631_Chip-Seq_BREAST_Human1.06729251
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05803797
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00991708
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00630046
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00400555
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00236364
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98881536
98OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98873482
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98648611
100TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97809580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.34265697
2MP0004264_abnormal_extraembryonic_tissu4.55946772
3MP0002796_impaired_skin_barrier3.76283218
4MP0003191_abnormal_cellular_cholesterol2.86217329
5MP0005501_abnormal_skin_physiology2.75170582
6MP0003566_abnormal_cell_adhesion2.53577250
7MP0003806_abnormal_nucleotide_metabolis2.52532982
8MP0005360_urolithiasis2.50462519
9MP0005083_abnormal_biliary_tract2.46638791
10MP0003315_abnormal_perineum_morphology2.31122685
11MP0000537_abnormal_urethra_morphology2.14054222
12MP0009780_abnormal_chondrocyte_physiolo2.10487507
13MP0001216_abnormal_epidermal_layer2.10406933
14MP0000762_abnormal_tongue_morphology2.08865170
15MP0000467_abnormal_esophagus_morphology2.06116247
16MP0002060_abnormal_skin_morphology2.05821141
17MP0002098_abnormal_vibrissa_morphology2.05070292
18MP0008260_abnormal_autophagy2.04446069
19MP0010678_abnormal_skin_adnexa2.04054558
20MP0003693_abnormal_embryo_hatching2.04053830
21MP0009840_abnormal_foam_cell1.98614041
22MP0010030_abnormal_orbit_morphology1.98521328
23MP0003941_abnormal_skin_development1.95147546
24MP0002877_abnormal_melanocyte_morpholog1.90925959
25MP0003123_paternal_imprinting1.90556409
26MP0001666_abnormal_nutrient_absorption1.88997437
27MP0009053_abnormal_anal_canal1.88684311
28MP0005257_abnormal_intraocular_pressure1.79542406
29MP0003453_abnormal_keratinocyte_physiol1.75225197
30MP0004272_abnormal_basement_membrane1.73404665
31MP0008875_abnormal_xenobiotic_pharmacok1.70872403
32MP0000579_abnormal_nail_morphology1.70578810
33MP0010352_gastrointestinal_tract_polyps1.66259343
34MP0005451_abnormal_body_composition1.64536930
35MP0010771_integument_phenotype1.63639512
36MP0003950_abnormal_plasma_membrane1.57444307
37MP0000516_abnormal_urinary_system1.55500638
38MP0005367_renal/urinary_system_phenotyp1.55500638
39MP0004957_abnormal_blastocyst_morpholog1.46582860
40MP0000383_abnormal_hair_follicle1.46527411
41MP0000627_abnormal_mammary_gland1.42054313
42MP0000750_abnormal_muscle_regeneration1.39125714
43MP0004019_abnormal_vitamin_homeostasis1.36197345
44MP0003705_abnormal_hypodermis_morpholog1.32612149
45MP0000377_abnormal_hair_follicle1.31317781
46MP0005165_increased_susceptibility_to1.29700708
47MP0005023_abnormal_wound_healing1.25692382
48MP0005670_abnormal_white_adipose1.25572541
49MP0000647_abnormal_sebaceous_gland1.17459142
50MP0000858_altered_metastatic_potential1.13976986
51MP0003786_premature_aging1.13738751
52MP0001881_abnormal_mammary_gland1.10028423
53MP0005365_abnormal_bile_salt1.09235740
54MP0005058_abnormal_lysosome_morphology1.07141605
55MP0005330_cardiomyopathy1.06712328
56MP0000462_abnormal_digestive_system1.03281410
57MP0000566_synostosis1.02021033
58MP0000427_abnormal_hair_cycle0.99613245
59MP0008007_abnormal_cellular_replicative0.98062397
60MP0000751_myopathy0.96956509
61MP0000538_abnormal_urinary_bladder0.95606617
62MP0003638_abnormal_response/metabolism_0.95371704
63MP0009931_abnormal_skin_appearance0.91934080
64MP0000490_abnormal_crypts_of0.91373127
65MP0004233_abnormal_muscle_weight0.89084587
66MP0000678_abnormal_parathyroid_gland0.88186652
67MP0003075_altered_response_to0.87409797
68MP0001243_abnormal_dermal_layer0.86469312
69MP0001849_ear_inflammation0.86186845
70MP0004782_abnormal_surfactant_physiolog0.84326862
71MP0000749_muscle_degeneration0.83699551
72MP0001727_abnormal_embryo_implantation0.81138488
73MP0009643_abnormal_urine_homeostasis0.80868206
74MP0001730_embryonic_growth_arrest0.80614327
75MP0001340_abnormal_eyelid_morphology0.79855879
76MP0000358_abnormal_cell_content/0.76809819
77MP0001873_stomach_inflammation0.75799825
78MP0000534_abnormal_ureter_morphology0.74562524
79MP0002177_abnormal_outer_ear0.74458343
80MP0000477_abnormal_intestine_morphology0.74004977
81MP0003718_maternal_effect0.73568625
82MP0001765_abnormal_ion_homeostasis0.73490566
83MP0004185_abnormal_adipocyte_glucose0.71760983
84MP0002234_abnormal_pharynx_morphology0.71360892
85MP0003936_abnormal_reproductive_system0.70658800
86MP0000613_abnormal_salivary_gland0.70363754
87MP0008932_abnormal_embryonic_tissue0.69600772
88MP0001542_abnormal_bone_strength0.68713442
89MP0003077_abnormal_cell_cycle0.67955669
90MP0002080_prenatal_lethality0.67684123
91MP0005085_abnormal_gallbladder_physiolo0.66291729
92MP0001664_abnormal_digestion0.65714467
93MP0005408_hypopigmentation0.65159037
94MP0002653_abnormal_ependyma_morphology0.64971077
95MP0000350_abnormal_cell_proliferation0.64944960
96MP0005197_abnormal_uvea_morphology0.63264341
97MP0000343_altered_response_to0.62907389
98MP0003866_abnormal_defecation0.62268068
99MP0005166_decreased_susceptibility_to0.61919589
100MP0000367_abnormal_coat/_hair0.61717123

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.21032033
2Vascular calcification (HP:0004934)4.30472327
3Abnormality of the distal phalanges of the toes (HP:0010182)4.03603921
4Distal lower limb muscle weakness (HP:0009053)3.96607885
5Pili torti (HP:0003777)3.74710030
6Cardiovascular calcification (HP:0011915)3.69986276
7Abnormal hair laboratory examination (HP:0003328)3.51738263
8Short nail (HP:0001799)3.41217378
9Onycholysis (HP:0001806)3.37194507
10Sparse eyelashes (HP:0000653)3.32535358
11Milia (HP:0001056)3.32113579
12Reduced subcutaneous adipose tissue (HP:0003758)3.28235108
13Alopecia of scalp (HP:0002293)3.26343055
14Fragile nails (HP:0001808)3.21331772
15Microglossia (HP:0000171)3.19586183
16Micronodular cirrhosis (HP:0001413)3.04841286
17Upper limb muscle weakness (HP:0003484)2.94588163
18Adrenal hypoplasia (HP:0000835)2.91445407
19Congenital ichthyosiform erythroderma (HP:0007431)2.88960228
20Plantar hyperkeratosis (HP:0007556)2.88262946
21Nail dystrophy (HP:0008404)2.86454777
22Glucose intolerance (HP:0000833)2.82427730
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.66335997
24Osteolytic defects of the hand bones (HP:0009699)2.66335997
25Abnormality of glycolysis (HP:0004366)2.66168567
26Atrophic scars (HP:0001075)2.61835977
27Abnormality of the umbilical cord (HP:0010881)2.61562940
28Selective tooth agenesis (HP:0001592)2.61036155
29Rough bone trabeculation (HP:0100670)2.60868746
30Distal lower limb amyotrophy (HP:0008944)2.59462612
31Thick nail (HP:0001805)2.54973036
32Axonal loss (HP:0003447)2.53448314
33Type I transferrin isoform profile (HP:0003642)2.52691832
34Increased serum pyruvate (HP:0003542)2.51673532
35Cholecystitis (HP:0001082)2.47834333
36Abnormal gallbladder physiology (HP:0012438)2.47834333
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.46926971
38Trismus (HP:0000211)2.45797612
39Delayed CNS myelination (HP:0002188)2.42992362
40Abnormalities of placenta or umbilical cord (HP:0001194)2.42565895
41Prolonged neonatal jaundice (HP:0006579)2.41380380
42Reduced antithrombin III activity (HP:0001976)2.38516449
43Vertebral compression fractures (HP:0002953)2.36416792
44Premature rupture of membranes (HP:0001788)2.36369965
45Entropion (HP:0000621)2.30728982
46Microretrognathia (HP:0000308)2.25038037
47Acanthosis nigricans (HP:0000956)2.22957323
48Septate vagina (HP:0001153)2.22532781
49Abnormal trabecular bone morphology (HP:0100671)2.22500297
50J-shaped sella turcica (HP:0002680)2.20649418
51Ridged nail (HP:0001807)2.20048634
52Abnormal glucose tolerance (HP:0001952)2.19869228
53Palpitations (HP:0001962)2.19836281
54Palmoplantar hyperkeratosis (HP:0000972)2.19201005
55Abdominal distention (HP:0003270)2.19074824
56Distal upper limb amyotrophy (HP:0007149)2.18971327
57Upper limb amyotrophy (HP:0009129)2.18971327
58Tongue fasciculations (HP:0001308)2.16929612
59Amyloidosis (HP:0011034)2.16431892
60Deviation of the thumb (HP:0009603)2.15396252
61Hepatocellular necrosis (HP:0001404)2.14061890
62Hypokinesia (HP:0002375)2.12294146
63Hepatic necrosis (HP:0002605)2.10537685
64Proximal placement of thumb (HP:0009623)2.08633494
65Abnormality of proline metabolism (HP:0010907)2.08031666
66Hydroxyprolinuria (HP:0003080)2.08031666
67Abnormal protein N-linked glycosylation (HP:0012347)2.06811246
68Abnormal protein glycosylation (HP:0012346)2.06811246
69Abnormal glycosylation (HP:0012345)2.06811246
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06811246
71Fasciculations (HP:0002380)2.06642990
72Ureteral duplication (HP:0000073)2.06435632
73Ventricular tachycardia (HP:0004756)2.04944711
74Natal tooth (HP:0000695)2.02784132
75Amelogenesis imperfecta (HP:0000705)2.02004593
76Woolly hair (HP:0002224)2.00801730
77Hyperacusis (HP:0010780)2.00593496
78Palmar hyperkeratosis (HP:0010765)2.00356329
79Hand muscle atrophy (HP:0009130)2.00216851
80Lip pit (HP:0100267)1.94915047
81Amniotic constriction ring (HP:0009775)1.93802744
82Abnormality of placental membranes (HP:0011409)1.93802744
83Increased connective tissue (HP:0009025)1.92881987
84Focal segmental glomerulosclerosis (HP:0000097)1.91021672
85Glomerulosclerosis (HP:0000096)1.90475092
86Hypoplasia of dental enamel (HP:0006297)1.88650927
87Progressive hearing impairment (HP:0001730)1.87112781
88Advanced eruption of teeth (HP:0006288)1.87104535
89Achilles tendon contracture (HP:0001771)1.87025053
90Abnormality of nail color (HP:0100643)1.83836787
91Gout (HP:0001997)1.82186450
92Testicular atrophy (HP:0000029)1.81505259
93Pterygium (HP:0001059)1.79655863
94Secondary amenorrhea (HP:0000869)1.79235929
95Down-sloping shoulders (HP:0200021)1.78095095
96Abnormal blistering of the skin (HP:0008066)1.77515915
97Abnormality of permanent molar morphology (HP:0011071)1.75772683
98Abnormality of the dental root (HP:0006486)1.75772683
99Taurodontia (HP:0000679)1.75772683
100Insulin resistance (HP:0000855)1.75225587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.54578152
2TESK14.03177955
3MST1R3.97937794
4NME23.69859962
5VRK23.48962542
6TESK23.16872527
7LMTK22.85952854
8MST42.82858200
9LIMK12.80038317
10MAP3K122.70680945
11MAPKAPK32.27534393
12PAK42.16142867
13RPS6KB21.87883087
14ERN11.86992515
15SIK11.86381949
16MET1.81200685
17SMG11.64423547
18TRIB31.62636745
19SCYL21.60759832
20ARAF1.51209383
21IRAK31.46302624
22BUB11.42364612
23DAPK11.39868539
24PIM21.33131577
25BCKDK1.31781141
26PTK21.29048194
27MAP3K31.28668645
28PBK1.22588663
29ERBB41.21729338
30NEK11.20425559
31ILK1.15812491
32PKN21.13099444
33FER1.07844361
34EIF2AK11.07066847
35SIK31.06721019
36MYLK0.99413627
37TSSK60.98185286
38TRIM280.98003968
39STK100.97366632
40EPHB10.96036080
41PRKCI0.95744777
42EPHB20.90023695
43PTK60.88757790
44ABL20.79688329
45RIPK10.75296654
46LRRK20.75285539
47CAMK2G0.73871753
48SRPK10.70416787
49STK160.68959764
50NME10.64615696
51TAOK20.64071950
52CDK70.62488396
53MAP3K90.59399330
54MAP2K70.57928779
55PRKG20.55298748
56MAP2K20.53966298
57DAPK30.53683777
58TBK10.53192128
59AURKB0.51166827
60MAP3K20.47903690
61MAP3K80.46067726
62AURKA0.45548368
63MAPKAPK20.45292726
64PHKG10.45010222
65PHKG20.45010222
66TAF10.42933078
67CAMK2D0.42484495
68CSNK1G30.40810270
69VRK10.39889909
70PIK3CA0.38024401
71CSNK1A1L0.37134597
72PAK10.37071630
73BMX0.36339425
74HIPK20.34366200
75NEK60.32105634
76RPS6KA40.31693788
77GRK50.29936683
78BRSK10.29820553
79CAMK2B0.29217605
80PDK20.28245983
81AKT20.27590365
82ROCK20.27365340
83MAP2K10.27084845
84CHUK0.26468571
85PLK10.25851076
86STK380.24912364
87MUSK0.24140077
88CDK120.23956502
89ERBB20.23005566
90MAP3K110.22303627
91BRAF0.22081462
92CDK80.21525489
93EIF2AK20.21282854
94TAOK10.19620723
95KDR0.17604896
96MTOR0.17594986
97PTK2B0.16977767
98ICK0.16703513
99ROCK10.16362072
100CSNK1G10.15945648

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.45892924
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.07615473
3Fatty acid elongation_Homo sapiens_hsa000622.69049003
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.67629217
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.59083282
6Fructose and mannose metabolism_Homo sapiens_hsa000512.57865495
7Galactose metabolism_Homo sapiens_hsa000522.56909902
8Folate biosynthesis_Homo sapiens_hsa007902.52625558
9Pentose phosphate pathway_Homo sapiens_hsa000302.34564597
10Glutathione metabolism_Homo sapiens_hsa004802.34548148
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.06409959
12Biosynthesis of amino acids_Homo sapiens_hsa012301.95528134
13Sulfur metabolism_Homo sapiens_hsa009201.83580332
14Sulfur relay system_Homo sapiens_hsa041221.79002504
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.78485930
16Carbon metabolism_Homo sapiens_hsa012001.72171076
17N-Glycan biosynthesis_Homo sapiens_hsa005101.69974460
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62244159
19DNA replication_Homo sapiens_hsa030301.60222976
20Pyruvate metabolism_Homo sapiens_hsa006201.57476006
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54280662
22Vibrio cholerae infection_Homo sapiens_hsa051101.50883225
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48362658
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47574226
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.46723647
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35456408
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32848808
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31572675
29Pyrimidine metabolism_Homo sapiens_hsa002401.31398473
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28148334
31Mismatch repair_Homo sapiens_hsa034301.28094102
32Starch and sucrose metabolism_Homo sapiens_hsa005001.26713657
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26624210
34Base excision repair_Homo sapiens_hsa034101.25049214
35Phenylalanine metabolism_Homo sapiens_hsa003601.25004541
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.24025361
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22822845
38Chemical carcinogenesis_Homo sapiens_hsa052041.22611008
39Oxidative phosphorylation_Homo sapiens_hsa001901.18162167
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16929423
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13709866
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06674361
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.06499572
44Steroid biosynthesis_Homo sapiens_hsa001001.03422412
45Nucleotide excision repair_Homo sapiens_hsa034201.02276363
46Tight junction_Homo sapiens_hsa045301.00869495
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97455108
48Thyroid cancer_Homo sapiens_hsa052160.96821255
49Vitamin digestion and absorption_Homo sapiens_hsa049770.95943621
50Arginine and proline metabolism_Homo sapiens_hsa003300.94302368
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91711941
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.90739233
53Huntingtons disease_Homo sapiens_hsa050160.88811914
54Histidine metabolism_Homo sapiens_hsa003400.86739651
55RNA polymerase_Homo sapiens_hsa030200.86557276
56Bladder cancer_Homo sapiens_hsa052190.83908984
57Fat digestion and absorption_Homo sapiens_hsa049750.81596942
58Other glycan degradation_Homo sapiens_hsa005110.81269817
59Tyrosine metabolism_Homo sapiens_hsa003500.80487182
60Alzheimers disease_Homo sapiens_hsa050100.77325454
61Parkinsons disease_Homo sapiens_hsa050120.76521161
62Ribosome_Homo sapiens_hsa030100.74842339
63Fatty acid metabolism_Homo sapiens_hsa012120.72993935
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71840295
65Metabolic pathways_Homo sapiens_hsa011000.71617538
66Arginine biosynthesis_Homo sapiens_hsa002200.70102631
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70050453
68Renin-angiotensin system_Homo sapiens_hsa046140.69660940
69Shigellosis_Homo sapiens_hsa051310.67640040
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62993359
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.61991928
72Hepatitis C_Homo sapiens_hsa051600.58617181
73Endocytosis_Homo sapiens_hsa041440.56985336
74beta-Alanine metabolism_Homo sapiens_hsa004100.56857398
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54862504
76Homologous recombination_Homo sapiens_hsa034400.51821104
77Mineral absorption_Homo sapiens_hsa049780.51229966
78Tryptophan metabolism_Homo sapiens_hsa003800.50571680
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49906724
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49740017
81Lysosome_Homo sapiens_hsa041420.48849607
82Retinol metabolism_Homo sapiens_hsa008300.48770708
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.48106724
84Adherens junction_Homo sapiens_hsa045200.47442877
85Purine metabolism_Homo sapiens_hsa002300.46355655
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46323975
87RNA transport_Homo sapiens_hsa030130.46235320
88Propanoate metabolism_Homo sapiens_hsa006400.42987178
89Spliceosome_Homo sapiens_hsa030400.39281574
90Hippo signaling pathway_Homo sapiens_hsa043900.39083111
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.38902585
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36993275
93p53 signaling pathway_Homo sapiens_hsa041150.35178239
94Peroxisome_Homo sapiens_hsa041460.34825299
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34491387
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33722146
97Proteoglycans in cancer_Homo sapiens_hsa052050.33715137
98Sphingolipid metabolism_Homo sapiens_hsa006000.33669367
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33415516
100Legionellosis_Homo sapiens_hsa051340.32097511

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