KRT19P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dopamine biosynthetic process (GO:0042416)9.18293082
2serotonin metabolic process (GO:0042428)8.75039965
3toxin metabolic process (GO:0009404)8.49246784
4primary amino compound metabolic process (GO:1901160)7.60423870
5indolalkylamine metabolic process (GO:0006586)7.28215385
6nephron epithelium morphogenesis (GO:0072088)6.22811284
7nephron tubule morphogenesis (GO:0072078)6.22811284
8hindbrain development (GO:0030902)5.91903848
9RNA destabilization (GO:0050779)5.81111815
10catechol-containing compound biosynthetic process (GO:0009713)5.41986600
11catecholamine biosynthetic process (GO:0042423)5.41986600
12nephron tubule formation (GO:0072079)5.29688869
13multicellular organismal aging (GO:0010259)5.18690150
14histone H3-K9 methylation (GO:0051567)5.17476541
15fatty acid elongation (GO:0030497)5.05819165
16indole-containing compound metabolic process (GO:0042430)4.79595210
17negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.79488818
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.78864674
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.69297527
20renal tubule morphogenesis (GO:0061333)4.65106876
21cellular biogenic amine biosynthetic process (GO:0042401)4.58789686
22negative regulation of metanephros development (GO:0072217)4.49453231
23amine biosynthetic process (GO:0009309)4.30530548
24intestinal epithelial cell development (GO:0060576)4.15146511
25dopamine metabolic process (GO:0042417)4.14239354
26response to UV-C (GO:0010225)4.04287508
27regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)4.01940482
28positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)4.01940482
29histone H3-K9 modification (GO:0061647)3.96998526
30basic amino acid transport (GO:0015802)3.92328102
31regulation of meiosis I (GO:0060631)3.91065892
32regulation of apoptotic process involved in morphogenesis (GO:1902337)3.86010533
33regulation of mesenchymal cell apoptotic process (GO:2001053)3.76793881
34ATP synthesis coupled proton transport (GO:0015986)3.67846377
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.67846377
36cellular response to ethanol (GO:0071361)3.60251552
37regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.49860283
38positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.49860283
39vitamin transmembrane transport (GO:0035461)3.48573664
40postsynaptic membrane organization (GO:0001941)3.45731949
41cerebellar Purkinje cell layer development (GO:0021680)3.45612028
42L-alpha-amino acid transmembrane transport (GO:1902475)3.36134341
43negative regulation of leukocyte chemotaxis (GO:0002689)3.34017230
44negative regulation of kidney development (GO:0090185)3.33746781
45opioid receptor signaling pathway (GO:0038003)3.31300681
46heparin biosynthetic process (GO:0030210)3.28211331
47heparin metabolic process (GO:0030202)3.28211331
48phasic smooth muscle contraction (GO:0014821)3.27459788
49platelet dense granule organization (GO:0060155)3.23923652
50protein-cofactor linkage (GO:0018065)3.15686569
51detection of light stimulus involved in visual perception (GO:0050908)3.11699532
52detection of light stimulus involved in sensory perception (GO:0050962)3.11699532
53positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.11016908
54iron coordination entity transport (GO:1901678)3.10714549
55transepithelial transport (GO:0070633)3.10483306
56regulation of stem cell maintenance (GO:2000036)3.09596212
57embryonic epithelial tube formation (GO:0001838)3.09535388
58negative regulation of execution phase of apoptosis (GO:1900118)3.04473240
59cellular response to alkaloid (GO:0071312)3.03739909
60protein ADP-ribosylation (GO:0006471)2.99445728
61central nervous system projection neuron axonogenesis (GO:0021952)2.95136439
62phenol-containing compound biosynthetic process (GO:0046189)2.94263588
63phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.93982919
64negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.93140580
65epithelial tube formation (GO:0072175)2.92133690
66lung lobe morphogenesis (GO:0060463)2.89783940
67regulation of glycogen (starch) synthase activity (GO:2000465)2.89707173
68poly(A)+ mRNA export from nucleus (GO:0016973)2.89681278
69central nervous system neuron axonogenesis (GO:0021955)2.89610255
70RNA localization (GO:0006403)2.89582080
71anterograde synaptic vesicle transport (GO:0048490)2.87891547
72monoubiquitinated protein deubiquitination (GO:0035520)2.81614228
73regulation of mRNA catabolic process (GO:0061013)2.80363030
74keratinocyte development (GO:0003334)2.79343897
75positive regulation of actin filament depolymerization (GO:0030836)2.78721211
76histone H3-K4 trimethylation (GO:0080182)2.75166127
77peristalsis (GO:0030432)2.73488898
78protein heterotetramerization (GO:0051290)2.71561227
79positive regulation of mRNA processing (GO:0050685)2.69826010
80mRNA cleavage (GO:0006379)2.68951260
81positive regulation of T cell apoptotic process (GO:0070234)2.68035636
82catecholamine metabolic process (GO:0006584)2.67986834
83catechol-containing compound metabolic process (GO:0009712)2.67986834
84establishment of protein localization to Golgi (GO:0072600)2.66810272
85galactose metabolic process (GO:0006012)2.65407337
86positive regulation of gastrulation (GO:2000543)2.65252661
87positive regulation of DNA-templated transcription, initiation (GO:2000144)2.63403589
88drug transmembrane transport (GO:0006855)2.62881647
89urinary tract smooth muscle contraction (GO:0014848)2.61093436
90secondary metabolic process (GO:0019748)2.61001063
91auditory receptor cell stereocilium organization (GO:0060088)2.55895593
92presynaptic membrane organization (GO:0097090)2.52305494
93regulation of hippo signaling (GO:0035330)2.52205439
94protein targeting to Golgi (GO:0000042)2.50703518
95positive regulation of lymphocyte apoptotic process (GO:0070230)2.50241257
96anterograde axon cargo transport (GO:0008089)2.49807722
97CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.49669392
98respiratory chain complex IV assembly (GO:0008535)2.49114820
99alkaloid metabolic process (GO:0009820)11.6992295
100response to insecticide (GO:0017085)10.0775997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.47177343
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.22364557
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.10068448
4GATA1_22025678_ChIP-Seq_K562_Human3.68044892
5EZH2_22144423_ChIP-Seq_EOC_Human3.64924568
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.25998684
7VDR_22108803_ChIP-Seq_LS180_Human2.97431505
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64165419
9ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.40671634
10TAF15_26573619_Chip-Seq_HEK293_Human2.26314883
11ZNF274_21170338_ChIP-Seq_K562_Hela2.11090757
12GBX2_23144817_ChIP-Seq_PC3_Human2.10272057
13NR3C1_21868756_ChIP-Seq_MCF10A_Human2.01924032
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99629337
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91397267
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90297213
17NR3C1_23031785_ChIP-Seq_PC12_Mouse1.81351249
18EGR1_23403033_ChIP-Seq_LIVER_Mouse1.81225879
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77807852
20FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.76684889
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71900773
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.67806692
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62691890
24STAT3_23295773_ChIP-Seq_U87_Human1.62624894
25CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61503766
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.61233208
27SMAD4_21799915_ChIP-Seq_A2780_Human1.60641847
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59431379
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55872203
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54726278
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53914203
32SMAD3_21741376_ChIP-Seq_HESCs_Human1.47427563
33P300_19829295_ChIP-Seq_ESCs_Human1.46160659
34P53_22127205_ChIP-Seq_FIBROBLAST_Human1.45349353
35AHR_22903824_ChIP-Seq_MCF-7_Human1.37981298
36SMAD4_21741376_ChIP-Seq_HESCs_Human1.33716110
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33591802
38TCF4_23295773_ChIP-Seq_U87_Human1.33277501
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31968309
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.28225612
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28119138
42IGF1R_20145208_ChIP-Seq_DFB_Human1.26357009
43FOXA1_25552417_ChIP-Seq_VCAP_Human1.25791438
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24102362
45CBP_20019798_ChIP-Seq_JUKART_Human1.23673970
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23673970
47BCAT_22108803_ChIP-Seq_LS180_Human1.21142720
48SOX2_19829295_ChIP-Seq_ESCs_Human1.21038496
49NANOG_19829295_ChIP-Seq_ESCs_Human1.21038496
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20311512
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19810530
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.19544233
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19528239
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18036393
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.17909207
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.17489356
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.17487047
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17022197
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.17022197
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16897613
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.16075204
62RXR_22108803_ChIP-Seq_LS180_Human1.15898563
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15786063
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14511122
65ER_23166858_ChIP-Seq_MCF-7_Human1.11772997
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10915574
67RUNX2_22187159_ChIP-Seq_PCA_Human1.10083480
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.09565768
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09466119
70AR_25329375_ChIP-Seq_VCAP_Human1.08556643
71AR_21572438_ChIP-Seq_LNCaP_Human1.07327450
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06558956
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06261162
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06213391
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03409884
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03058007
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02842381
78DROSHA_22980978_ChIP-Seq_HELA_Human1.02433743
79GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01826340
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.01191593
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00903525
82STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00341369
83ERA_21632823_ChIP-Seq_H3396_Human0.99846822
84SALL4_22934838_ChIP-ChIP_CD34+_Human0.96973667
85TP63_19390658_ChIP-ChIP_HaCaT_Human0.96838412
86ESR1_20079471_ChIP-ChIP_T-47D_Human0.96348378
87E2F1_18555785_Chip-Seq_ESCs_Mouse0.95869302
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95025046
89SALL1_21062744_ChIP-ChIP_HESCs_Human0.94732441
90SOX2_18555785_Chip-Seq_ESCs_Mouse0.94522394
91EED_16625203_ChIP-ChIP_MESCs_Mouse0.93564827
92SOX2_21211035_ChIP-Seq_LN229_Gbm0.93437088
93P53_22387025_ChIP-Seq_ESCs_Mouse0.93226350
94EZH2_27304074_Chip-Seq_ESCs_Mouse0.93118021
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92629464
96EWS_26573619_Chip-Seq_HEK293_Human0.92232971
97ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91998168
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.91608732
99REST_21632747_ChIP-Seq_MESCs_Mouse0.91473069
100FUS_26573619_Chip-Seq_HEK293_Human0.91291254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.28581799
2MP0000569_abnormal_digit_pigmentation5.91432262
3MP0002138_abnormal_hepatobiliary_system4.94564875
4MP0005423_abnormal_somatic_nervous4.44281378
5MP0004381_abnormal_hair_follicle3.84903089
6MP0005645_abnormal_hypothalamus_physiol3.82682158
7MP0003195_calcinosis3.44245510
8MP0002163_abnormal_gland_morphology2.92007755
9MP0005379_endocrine/exocrine_gland_phen2.85540796
10MP0003880_abnormal_central_pattern2.79967497
11MP0002166_altered_tumor_susceptibility2.68638843
12MP0005075_abnormal_melanosome_morpholog2.59750221
13MP0002837_dystrophic_cardiac_calcinosis2.51323324
14MP0005084_abnormal_gallbladder_morpholo2.48607134
15MP0002006_tumorigenesis2.23204401
16MP0003172_abnormal_lysosome_physiology2.10791707
17MP0009046_muscle_twitch1.88911432
18MP0005220_abnormal_exocrine_pancreas1.81412499
19MP0002928_abnormal_bile_duct1.67212854
20MP0009745_abnormal_behavioral_response1.52252429
21MP0001905_abnormal_dopamine_level1.49302523
22MP0008877_abnormal_DNA_methylation1.44635925
23MP0005646_abnormal_pituitary_gland1.43384397
24MP0002064_seizures1.42517338
25MP0002168_other_aberrant_phenotype1.38864729
26MP0002272_abnormal_nervous_system1.32761745
27MP0000631_abnormal_neuroendocrine_gland1.32379973
28MP0005670_abnormal_white_adipose1.30683303
29MP0004742_abnormal_vestibular_system1.30130017
30MP0005451_abnormal_body_composition1.28228470
31MP0008872_abnormal_physiological_respon1.27815248
32MP0005386_behavior/neurological_phenoty1.27397885
33MP0004924_abnormal_behavior1.27397885
34MP0002751_abnormal_autonomic_nervous1.25505028
35MP0003787_abnormal_imprinting1.22822490
36MP0003045_fibrosis1.22791987
37MP0000013_abnormal_adipose_tissue1.22295031
38MP0001486_abnormal_startle_reflex1.19353233
39MP0003942_abnormal_urinary_system1.18762597
40MP0004270_analgesia1.14804939
41MP0001968_abnormal_touch/_nociception1.12407753
42MP0002909_abnormal_adrenal_gland1.11460398
43MP0005187_abnormal_penis_morphology1.08462859
44MP0002572_abnormal_emotion/affect_behav1.05253998
45MP0001756_abnormal_urination1.04367836
46MP0000647_abnormal_sebaceous_gland1.04251701
47MP0001986_abnormal_taste_sensitivity1.02967390
48MP0004145_abnormal_muscle_electrophysio1.00432840
49MP0002693_abnormal_pancreas_physiology0.98685545
50MP0005397_hematopoietic_system_phenotyp0.97324839
51MP0001545_abnormal_hematopoietic_system0.97324839
52MP0002735_abnormal_chemical_nociception0.94284794
53MP0003890_abnormal_embryonic-extraembry0.93391253
54MP0002067_abnormal_sensory_capabilities0.92890124
55MP0009278_abnormal_bone_marrow0.92343002
56MP0003137_abnormal_impulse_conducting0.92037133
57MP0002876_abnormal_thyroid_physiology0.90862164
58MP0008875_abnormal_xenobiotic_pharmacok0.90737535
59MP0000372_irregular_coat_pigmentation0.88697274
60MP0000639_abnormal_adrenal_gland0.87238388
61MP0003635_abnormal_synaptic_transmissio0.82884958
62MP0003866_abnormal_defecation0.81800484
63MP0002184_abnormal_innervation0.77890078
64MP0003937_abnormal_limbs/digits/tail_de0.76158005
65MP0005551_abnormal_eye_electrophysiolog0.73261334
66MP0010329_abnormal_lipoprotein_level0.72748006
67MP0001879_abnormal_lymphatic_vessel0.72364277
68MP0001944_abnormal_pancreas_morphology0.67783270
69MP0000015_abnormal_ear_pigmentation0.67531749
70MP0000516_abnormal_urinary_system0.67134954
71MP0005367_renal/urinary_system_phenotyp0.67134954
72MP0001970_abnormal_pain_threshold0.67063740
73MP0003191_abnormal_cellular_cholesterol0.66002526
74MP0004142_abnormal_muscle_tone0.65758251
75MP0002736_abnormal_nociception_after0.65474218
76MP0002734_abnormal_mechanical_nocicepti0.63917191
77MP0002063_abnormal_learning/memory/cond0.62034755
78MP0005395_other_phenotype0.61702671
79MP0002229_neurodegeneration0.60772572
80MP0000003_abnormal_adipose_tissue0.57332497
81MP0001286_abnormal_eye_development0.56015381
82MP0009703_decreased_birth_body0.55942106
83MP0006035_abnormal_mitochondrial_morpho0.55683530
84MP0004215_abnormal_myocardial_fiber0.54715789
85MP0004811_abnormal_neuron_physiology0.52681501
86MP0002078_abnormal_glucose_homeostasis0.52379490
87MP0001790_abnormal_immune_system0.52275207
88MP0005387_immune_system_phenotype0.52275207
89MP0002557_abnormal_social/conspecific_i0.50366864
90MP0002882_abnormal_neuron_morphology0.49594848
91MP0001765_abnormal_ion_homeostasis0.49075292
92MP0002009_preneoplasia0.48415993
93MP0000778_abnormal_nervous_system0.48322207
94MP0004885_abnormal_endolymph0.48026812
95MP0006036_abnormal_mitochondrial_physio0.47472216
96MP0005410_abnormal_fertilization0.47056008
97MP0005248_abnormal_Harderian_gland0.45515081
98MP0002177_abnormal_outer_ear0.44152645
99MP0004043_abnormal_pH_regulation0.43782482
100MP0003698_abnormal_male_reproductive0.42966538

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)9.93787806
2Limb dystonia (HP:0002451)9.46431821
3Abnormal pupillary function (HP:0007686)9.11915946
4Limb hypertonia (HP:0002509)8.23819119
5Pheochromocytoma (HP:0002666)5.85923561
6Neuroendocrine neoplasm (HP:0100634)5.34658602
7Gout (HP:0001997)4.48056581
8Medial flaring of the eyebrow (HP:0010747)4.43462493
9Type II lissencephaly (HP:0007260)4.15114565
10Hypoplasia of the uterus (HP:0000013)3.91186425
11Conjunctival hamartoma (HP:0100780)3.90054912
12Abnormal pancreas size (HP:0012094)3.89351841
13Abnormality of urine glucose concentration (HP:0011016)3.77794826
14Glycosuria (HP:0003076)3.77794826
15Retinal dysplasia (HP:0007973)3.66415459
16Late onset (HP:0003584)3.58485847
17Cerebral hemorrhage (HP:0001342)3.58417806
18Unilateral renal agenesis (HP:0000122)3.31229324
193-Methylglutaconic aciduria (HP:0003535)3.15616784
20Hamartoma of the eye (HP:0010568)3.11238472
21Fetal akinesia sequence (HP:0001989)3.10801759
22Hypophosphatemic rickets (HP:0004912)3.04901818
23Abnormal number of erythroid precursors (HP:0012131)3.04693467
24Renal cortical cysts (HP:0000803)2.90642559
25Proximal tubulopathy (HP:0000114)2.87740861
26Cerebellar dysplasia (HP:0007033)2.74371272
27Bicornuate uterus (HP:0000813)2.69181002
28Aplasia/hypoplasia of the uterus (HP:0008684)2.68613659
29Neoplasm of the peripheral nervous system (HP:0100007)2.66931912
30Abnormality of the pupil (HP:0000615)2.58110604
31Meningioma (HP:0002858)2.54261643
32Progressive macrocephaly (HP:0004481)2.50209960
33Akinesia (HP:0002304)2.49912177
34Decreased muscle mass (HP:0003199)2.48781467
35Renal hypoplasia (HP:0000089)2.47892684
36Hypotension (HP:0002615)2.45791106
37Decreased central vision (HP:0007663)2.42898782
38Focal motor seizures (HP:0011153)2.39939495
39Shawl scrotum (HP:0000049)2.39097409
40Increased purine levels (HP:0004368)2.31537481
41Hyperuricemia (HP:0002149)2.31537481
42Abnormality of cells of the erythroid lineage (HP:0012130)2.29665702
43Chronic sinusitis (HP:0011109)2.28714680
44Glucose intolerance (HP:0000833)2.24697679
45Tinnitus (HP:0000360)2.21706581
46Abnormal respiratory epithelium morphology (HP:0012253)2.18925822
47Abnormal respiratory motile cilium morphology (HP:0005938)2.18925822
48Protruding tongue (HP:0010808)2.18631192
49Lissencephaly (HP:0001339)2.18402730
50Gastrointestinal stroma tumor (HP:0100723)2.12974756
51Osteomalacia (HP:0002749)2.08047169
52Emotional lability (HP:0000712)2.05281678
53Severe muscular hypotonia (HP:0006829)2.03204884
54Large for gestational age (HP:0001520)2.02415305
55Increased hepatocellular lipid droplets (HP:0006565)2.00682765
56Enlarged epiphyses (HP:0010580)1.99316118
57Choreoathetosis (HP:0001266)1.97120750
58Mutism (HP:0002300)1.94180951
59Tubulointerstitial fibrosis (HP:0005576)1.94050889
60Abolished electroretinogram (ERG) (HP:0000550)1.92651989
61Delayed epiphyseal ossification (HP:0002663)1.89609163
62Thin bony cortex (HP:0002753)1.88932742
63Bony spicule pigmentary retinopathy (HP:0007737)1.88511589
64Lipid accumulation in hepatocytes (HP:0006561)1.85858678
65Mitochondrial inheritance (HP:0001427)1.85376304
66Morphological abnormality of the middle ear (HP:0008609)1.85330985
67Anterior segment dysgenesis (HP:0007700)1.84768989
68Gaze-evoked nystagmus (HP:0000640)1.83595793
69Increased CSF lactate (HP:0002490)1.83557994
70Acute necrotizing encephalopathy (HP:0006965)1.81910453
71Tubular atrophy (HP:0000092)1.80763997
72Ureteral stenosis (HP:0000071)1.74333942
73Diminished movement (HP:0002374)1.73573081
74Vascular calcification (HP:0004934)1.72817573
75Exertional dyspnea (HP:0002875)1.71234196
76Abnormal ciliary motility (HP:0012262)1.71206179
77Abnormality of incisor morphology (HP:0011063)1.69756910
78Abnormality of the renal cortex (HP:0011035)1.68782400
79Chronic hepatic failure (HP:0100626)1.68571245
80Gastroesophageal reflux (HP:0002020)1.68569884
81Abnormality of male internal genitalia (HP:0000022)1.67605404
82Abnormal glucose tolerance (HP:0001952)1.67069493
83Hypoplasia of the brainstem (HP:0002365)1.65857210
84Aplasia/Hypoplasia of the brainstem (HP:0007362)1.65857210
85Aqueductal stenosis (HP:0002410)1.64629999
86Inability to walk (HP:0002540)1.63711339
87Hyperphosphaturia (HP:0003109)1.61333435
88Acute lymphatic leukemia (HP:0006721)1.60701111
89Hyperventilation (HP:0002883)1.60211280
90Prominent supraorbital ridges (HP:0000336)1.58973525
91Ureteral obstruction (HP:0006000)1.58253242
92Pachygyria (HP:0001302)1.57768191
93Fatigue (HP:0012378)1.57381208
94Polymicrogyria (HP:0002126)1.57213646
95Macroglossia (HP:0000158)1.57163503
96Bone cyst (HP:0012062)1.57054407
97Abnormality of midbrain morphology (HP:0002418)1.56122533
98Molar tooth sign on MRI (HP:0002419)1.56122533
99Multicystic kidney dysplasia (HP:0000003)1.55278455
100Absent phalangeal crease (HP:0006109)1.50532184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK9.22961235
2CAMK1G4.81820407
3FRK4.41240262
4ADRBK23.20945149
5BRD43.09597575
6MAP3K92.86089606
7STK242.85227034
8CDK192.32724132
9MAP2K62.07820412
10OXSR11.98989478
11PHKG11.89782337
12PHKG21.89782337
13GRK11.74273757
14MAPK131.72522568
15EIF2AK31.59970847
16CAMK11.48960968
17FGFR21.47340738
18PTK2B1.32256677
19TLK11.31651160
20NUAK11.21709246
21BLK1.11224842
22MAP3K41.09214613
23NEK21.07772016
24EIF2AK11.05769995
25ERBB20.99933902
26PINK10.99626209
27MAP3K70.99310335
28TGFBR20.92209096
29MAPK120.91550968
30BRAF0.91349396
31MAPKAPK50.90138697
32CAMK1D0.89835854
33STK390.88809937
34WNK30.87303316
35TAOK30.85777425
36SYK0.80512060
37STK110.78709931
38MAP2K20.76797222
39MARK10.73688612
40TEC0.72742791
41VRK20.72468132
42PRKCE0.69306994
43SIK20.69153093
44FGFR30.69044935
45DAPK20.68719218
46FGFR10.68003790
47PDK10.67891566
48BUB10.64781492
49ITK0.64756337
50MAPK70.63941419
51ILK0.61856947
52OBSCN0.61372529
53RIPK40.58241364
54CHUK0.58078835
55RPS6KA40.56720314
56INSRR0.52482779
57IKBKB0.52438030
58BCR0.49214693
59MAP4K10.49069970
60CSNK1G20.46283002
61PRKAA20.45470902
62PDPK10.42531718
63BMPR1B0.42002562
64PRKACB0.41096128
65CAMK40.40077843
66MAP4K20.39638602
67NTRK20.38939412
68ATR0.35938079
69IRAK10.35567314
70CAMK2D0.34897202
71PKN10.34560642
72RPS6KB10.34491161
73RPS6KB20.32709940
74TRPM70.31583929
75SGK30.30805889
76DAPK30.30159500
77PLK20.29684817
78PRKD10.28744128
79PRKCG0.28490770
80SGK20.27860583
81CDK50.27286896
82MKNK20.27054616
83PRKCH0.25493850
84MAPK80.24495128
85TYK20.24103710
86NME10.24093727
87FER0.23949476
88CAMK2A0.23945964
89CDC42BPA0.22591320
90CSNK1A10.22587239
91WNK10.22076958
92MINK10.21027147
93PAK30.21008072
94CDK60.20362686
95MAPKAPK30.19880472
96PRKACA0.16958820
97PRKAA10.16953839
98MAPK40.16810981
99MYLK0.16713948
100TRIB30.16178037

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003605.30824425
2Histidine metabolism_Homo sapiens_hsa003404.61668624
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.33198673
4Protein export_Homo sapiens_hsa030603.85715093
5Tryptophan metabolism_Homo sapiens_hsa003803.05003859
6Amphetamine addiction_Homo sapiens_hsa050312.56520385
7Tyrosine metabolism_Homo sapiens_hsa003502.55169894
8Cocaine addiction_Homo sapiens_hsa050302.52186613
9Dorso-ventral axis formation_Homo sapiens_hsa043202.35859438
10Oxidative phosphorylation_Homo sapiens_hsa001902.06704958
11Phototransduction_Homo sapiens_hsa047442.05363351
12Ether lipid metabolism_Homo sapiens_hsa005652.03502420
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.99543281
14Nicotine addiction_Homo sapiens_hsa050331.93661728
15Fatty acid elongation_Homo sapiens_hsa000621.80083596
16Serotonergic synapse_Homo sapiens_hsa047261.70546885
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.52434987
18Linoleic acid metabolism_Homo sapiens_hsa005911.46862395
19Caffeine metabolism_Homo sapiens_hsa002321.38934951
20Parkinsons disease_Homo sapiens_hsa050121.38895733
21Collecting duct acid secretion_Homo sapiens_hsa049661.38552618
22Dopaminergic synapse_Homo sapiens_hsa047281.32908832
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29330448
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14396321
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13135238
26Selenocompound metabolism_Homo sapiens_hsa004501.12592204
27Sphingolipid metabolism_Homo sapiens_hsa006001.12013825
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08099639
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05933712
30Retinol metabolism_Homo sapiens_hsa008301.00080681
31Morphine addiction_Homo sapiens_hsa050320.99614585
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96070388
33Alzheimers disease_Homo sapiens_hsa050100.94762409
34GABAergic synapse_Homo sapiens_hsa047270.91713441
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91575298
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89891366
37Primary bile acid biosynthesis_Homo sapiens_hsa001200.87727680
38Long-term depression_Homo sapiens_hsa047300.83969151
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83563879
40Taste transduction_Homo sapiens_hsa047420.83161459
41Steroid hormone biosynthesis_Homo sapiens_hsa001400.82108416
42Oxytocin signaling pathway_Homo sapiens_hsa049210.81325109
43Olfactory transduction_Homo sapiens_hsa047400.77951312
44Nitrogen metabolism_Homo sapiens_hsa009100.76832692
45Peroxisome_Homo sapiens_hsa041460.76238824
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76144010
47Synaptic vesicle cycle_Homo sapiens_hsa047210.75096763
48Huntingtons disease_Homo sapiens_hsa050160.73882050
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70723996
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68481833
51Ovarian steroidogenesis_Homo sapiens_hsa049130.66950584
52Chemical carcinogenesis_Homo sapiens_hsa052040.66690635
53Circadian entrainment_Homo sapiens_hsa047130.66592291
54Alcoholism_Homo sapiens_hsa050340.66498152
55Renal cell carcinoma_Homo sapiens_hsa052110.65142705
56Cholinergic synapse_Homo sapiens_hsa047250.64308104
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62534084
58Type I diabetes mellitus_Homo sapiens_hsa049400.58361809
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58327121
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57922646
61Butanoate metabolism_Homo sapiens_hsa006500.57013424
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.56751326
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54965075
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54082884
65Glutamatergic synapse_Homo sapiens_hsa047240.53789276
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49687421
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49126305
68Cardiac muscle contraction_Homo sapiens_hsa042600.47932757
69beta-Alanine metabolism_Homo sapiens_hsa004100.47203517
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44573891
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43320379
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43273116
73ABC transporters_Homo sapiens_hsa020100.42707087
74Vitamin digestion and absorption_Homo sapiens_hsa049770.42011524
75MAPK signaling pathway_Homo sapiens_hsa040100.40685924
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38151150
77Inositol phosphate metabolism_Homo sapiens_hsa005620.37403093
78Steroid biosynthesis_Homo sapiens_hsa001000.34679112
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.33860241
80GnRH signaling pathway_Homo sapiens_hsa049120.31977188
81Metabolic pathways_Homo sapiens_hsa011000.31206147
82Renin secretion_Homo sapiens_hsa049240.30605136
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30584526
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30358188
85Renin-angiotensin system_Homo sapiens_hsa046140.27858703
86T cell receptor signaling pathway_Homo sapiens_hsa046600.27614504
87cAMP signaling pathway_Homo sapiens_hsa040240.27019350
88Prostate cancer_Homo sapiens_hsa052150.25726839
89Melanoma_Homo sapiens_hsa052180.25654701
90B cell receptor signaling pathway_Homo sapiens_hsa046620.24351457
91Vibrio cholerae infection_Homo sapiens_hsa051100.24331346
92Glioma_Homo sapiens_hsa052140.21599999
93Hedgehog signaling pathway_Homo sapiens_hsa043400.21488839
94mRNA surveillance pathway_Homo sapiens_hsa030150.21370681
95Basal transcription factors_Homo sapiens_hsa030220.18622620
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16695839
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15849532
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.15042785
99RNA transport_Homo sapiens_hsa030130.14990035
100Oocyte meiosis_Homo sapiens_hsa041140.14298599

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