KRT20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)9.61119785
2angiotensin maturation (GO:0002003)9.36249116
3regulation of guanylate cyclase activity (GO:0031282)6.99792626
4vitamin A metabolic process (GO:0006776)6.73664319
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.30625583
6maintenance of gastrointestinal epithelium (GO:0030277)6.28967404
7actin filament depolymerization (GO:0030042)6.16433353
8bundle of His cell to Purkinje myocyte communication (GO:0086069)6.03497107
9UDP-N-acetylglucosamine metabolic process (GO:0006047)5.87404050
10cellular glucuronidation (GO:0052695)5.67369692
11adhesion of symbiont to host cell (GO:0044650)5.60642997
12virion attachment to host cell (GO:0019062)5.60642997
13NADH metabolic process (GO:0006734)5.54390341
14digestive system process (GO:0022600)5.53564262
15glucuronate metabolic process (GO:0019585)5.50265864
16uronic acid metabolic process (GO:0006063)5.50265864
17purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.38060802
183-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.38060802
19positive regulation of respiratory burst (GO:0060267)5.34505545
20flavonoid metabolic process (GO:0009812)5.32371085
21regulation of cellular extravasation (GO:0002691)5.18336094
22drug catabolic process (GO:0042737)5.10214908
23epoxygenase P450 pathway (GO:0019373)5.08773989
24positive regulation of guanylate cyclase activity (GO:0031284)5.02540062
25fat-soluble vitamin biosynthetic process (GO:0042362)4.85079306
26epithelial structure maintenance (GO:0010669)4.82486463
27phospholipid efflux (GO:0033700)4.82293941
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.79225655
29renal system process involved in regulation of blood volume (GO:0001977)4.76750612
30receptor guanylyl cyclase signaling pathway (GO:0007168)4.69238624
31regulation of cholesterol esterification (GO:0010872)4.55767753
32adhesion of symbiont to host (GO:0044406)4.53047786
33positive regulation of triglyceride lipase activity (GO:0061365)4.52113727
34positive regulation of lipoprotein lipase activity (GO:0051006)4.52113727
35regulation of vitamin metabolic process (GO:0030656)4.49097757
36intestinal epithelial cell development (GO:0060576)4.47659217
37sulfate transmembrane transport (GO:1902358)4.46723601
38positive regulation of pseudopodium assembly (GO:0031274)4.46242641
39regulation of bile acid biosynthetic process (GO:0070857)4.43853724
40digestion (GO:0007586)4.42943540
41lipoprotein metabolic process (GO:0042157)4.40594564
42bile acid and bile salt transport (GO:0015721)4.37347688
43plasma lipoprotein particle assembly (GO:0034377)4.36611644
44O-glycan processing (GO:0016266)4.34603337
45glomerular filtration (GO:0003094)4.31521765
46regulation of triglyceride catabolic process (GO:0010896)4.25912733
47regulation of cGMP biosynthetic process (GO:0030826)4.22098312
48response to hepatocyte growth factor (GO:0035728)4.21787872
49cellular response to hepatocyte growth factor stimulus (GO:0035729)4.21787872
50hormone catabolic process (GO:0042447)4.20013042
51protein-lipid complex assembly (GO:0065005)4.19521578
52modified amino acid transport (GO:0072337)4.12884318
53urea cycle (GO:0000050)3.99696618
54regulation of pseudopodium assembly (GO:0031272)3.99553083
55sulfation (GO:0051923)3.99502983
56renal filtration (GO:0097205)3.97070511
57sulfur compound transport (GO:0072348)3.96393759
58hemidesmosome assembly (GO:0031581)3.91071578
59drug metabolic process (GO:0017144)3.90183622
60oligosaccharide biosynthetic process (GO:0009312)3.90173128
61regulation of respiratory burst (GO:0060263)3.86031053
62ethanol oxidation (GO:0006069)3.85866023
63glucose 6-phosphate metabolic process (GO:0051156)3.84821245
64desmosome organization (GO:0002934)3.83913320
65urea metabolic process (GO:0019627)3.75993637
66thyroid hormone metabolic process (GO:0042403)3.75464646
67cholesterol efflux (GO:0033344)3.72292201
68regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.70989706
69positive regulation of fatty acid beta-oxidation (GO:0032000)3.66376102
70regulation of cholesterol homeostasis (GO:2000188)3.66026497
71fructose metabolic process (GO:0006000)3.63940468
72sulfate transport (GO:0008272)3.63030858
73cholesterol homeostasis (GO:0042632)3.59938409
74very-low-density lipoprotein particle assembly (GO:0034379)3.59250450
75peptide hormone processing (GO:0016486)3.58970998
76sterol homeostasis (GO:0055092)3.58886630
77negative regulation of sterol transport (GO:0032372)3.58884884
78negative regulation of cholesterol transport (GO:0032375)3.58884884
79diacylglycerol metabolic process (GO:0046339)3.58094400
80cGMP-mediated signaling (GO:0019934)3.56753048
81drinking behavior (GO:0042756)3.56578395
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56292563
83hepatocyte apoptotic process (GO:0097284)3.53881151
84glycosphingolipid catabolic process (GO:0046479)3.50474413
85peptide catabolic process (GO:0043171)3.47382781
86regulation of cGMP metabolic process (GO:0030823)3.46615369
87positive regulation of glycoprotein biosynthetic process (GO:0010560)3.46566448
88glycolipid catabolic process (GO:0019377)3.44757866
89bicarbonate transport (GO:0015701)3.44754514
90nitrogen cycle metabolic process (GO:0071941)3.44419166
91nucleoside diphosphate biosynthetic process (GO:0009133)3.43013689
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.42289283
93renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.40140041
94lipoprotein transport (GO:0042953)3.39454328
95fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.35280114
96sterol transport (GO:0015918)3.33618074
97cholesterol transport (GO:0030301)3.33618074
98transcytosis (GO:0045056)3.33509886
99phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.31508668
100reverse cholesterol transport (GO:0043691)3.28735883
101auditory receptor cell differentiation (GO:0042491)3.28289367
102positive regulation of fatty acid biosynthetic process (GO:0045723)3.28209640
103drug transmembrane transport (GO:0006855)3.26843189
104glucocorticoid biosynthetic process (GO:0006704)3.26054775
105nucleotide-sugar biosynthetic process (GO:0009226)3.24088537
106positive regulation of glycoprotein metabolic process (GO:1903020)3.23738134
107sperm capacitation (GO:0048240)3.21012125
108vitamin transmembrane transport (GO:0035461)3.20249275
109drug transport (GO:0015893)3.18921948
110antigen processing and presentation of endogenous antigen (GO:0019883)3.18917810
111thrombin receptor signaling pathway (GO:0070493)3.17688557
112arginine metabolic process (GO:0006525)3.17264652
113positive regulation of Cdc42 GTPase activity (GO:0043089)3.16913174
114hydrogen peroxide catabolic process (GO:0042744)3.14662720
115purine nucleotide salvage (GO:0032261)3.13647880
116exogenous drug catabolic process (GO:0042738)3.13606619
117regulation of actin nucleation (GO:0051125)3.11664815
118regulation of systemic arterial blood pressure by hormone (GO:0001990)3.09142582
119regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.09142582
120endocrine process (GO:0050886)3.09142582
121positive regulation of lipid catabolic process (GO:0050996)3.08882901
122cytidine metabolic process (GO:0046087)3.08082754
123cytidine catabolic process (GO:0006216)3.08082754
124cytidine deamination (GO:0009972)3.08082754
125calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.06634349
126response to hydroperoxide (GO:0033194)3.01597093
127ethanol metabolic process (GO:0006067)3.01445630
128eosinophil chemotaxis (GO:0048245)2.96778962
129alkaloid metabolic process (GO:0009820)2.96756161
130GDP-mannose metabolic process (GO:0019673)2.96629839
131sodium ion homeostasis (GO:0055078)2.96019531
132glycosylceramide metabolic process (GO:0006677)2.94424662
133glycerol metabolic process (GO:0006071)2.93900143
134bile acid metabolic process (GO:0008206)2.92687949
135nucleotide-sugar metabolic process (GO:0009225)2.90905306
136high-density lipoprotein particle remodeling (GO:0034375)2.90728801
137protein-lipid complex remodeling (GO:0034368)2.89354916
138macromolecular complex remodeling (GO:0034367)2.89354916
139plasma lipoprotein particle remodeling (GO:0034369)2.89354916
140ventricular cardiac muscle cell action potential (GO:0086005)2.89299125
141citrulline biosynthetic process (GO:0019240)2.89088780
142striated muscle atrophy (GO:0014891)2.87998174
143sphingomyelin metabolic process (GO:0006684)2.86933077
144positive regulation of triglyceride metabolic process (GO:0090208)2.86287715
145positive regulation of cGMP biosynthetic process (GO:0030828)2.86127616
146glutamine family amino acid biosynthetic process (GO:0009084)2.85748935
147antimicrobial humoral response (GO:0019730)2.84872563
148regulation of viral release from host cell (GO:1902186)2.84681511
149antibacterial humoral response (GO:0019731)2.83921703
150pyrimidine-containing compound transmembrane transport (GO:0072531)2.83381715
151transepithelial transport (GO:0070633)2.81788566
152negative regulation of digestive system process (GO:0060457)2.77470566
153protein-lipid complex subunit organization (GO:0071825)2.77012015
154plasma lipoprotein particle organization (GO:0071827)2.76612772
155positive regulation of T cell differentiation in thymus (GO:0033089)2.76087271
156oligosaccharide catabolic process (GO:0009313)2.75505111
157regulation of systemic arterial blood pressure (GO:0003073)2.75056624
158intestinal absorption (GO:0050892)10.8266976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.21529193
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.24497164
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.83958206
4GATA4_25053715_ChIP-Seq_YYC3_Human3.07158928
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.02447396
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.97473561
7* SOX2_20726797_ChIP-Seq_SW620_Human2.84937707
8GATA6_25053715_ChIP-Seq_YYC3_Human2.81072962
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.72661507
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.64003071
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.54250467
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.50846699
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.46594923
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.24749025
15* LXR_22158963_ChIP-Seq_LIVER_Mouse2.24173208
16* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03940685
17* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.03430104
18SRY_22984422_ChIP-ChIP_TESTIS_Rat2.01287814
19* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.89922332
20KLF5_25053715_ChIP-Seq_YYC3_Human1.89827773
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85878603
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.84775673
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.80051614
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.79658701
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73360837
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.72520793
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.69788773
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.69014832
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.66632020
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64704278
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.64323525
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.62351445
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61378753
34RACK7_27058665_Chip-Seq_MCF-7_Human1.60814091
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60629976
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57230003
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.56109195
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55036782
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48446682
40ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46456760
41ATF3_27146783_Chip-Seq_COLON_Human1.45688151
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43118604
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41139234
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37948633
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37517867
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35643063
47CLOCK_20551151_ChIP-Seq_293T_Human1.35600928
48GATA2_19941826_ChIP-Seq_K562_Human1.35187321
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34313494
50FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32669218
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32087945
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29967531
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29281174
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26272485
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26217812
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25986382
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25986382
58JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25688493
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23623466
60HNF4A_19822575_ChIP-Seq_HepG2_Human1.21554021
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13336940
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.10971456
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10105392
64JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.08348782
65ZNF263_19887448_ChIP-Seq_K562_Human1.08055330
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07843334
67CREB1_26743006_Chip-Seq_LNCaP_Human1.06807015
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06348279
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05346445
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.04227908
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03996313
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02364941
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01750204
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.01268039
75GATA1_22025678_ChIP-Seq_K562_Human1.00595828
76IRF8_21731497_ChIP-ChIP_J774_Mouse0.99357831
77EGR1_19032775_ChIP-ChIP_M12_Human0.98476847
78VDR_22108803_ChIP-Seq_LS180_Human0.97716542
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97259209
80* CEBPB_22108803_ChIP-Seq_LS180_Human0.96068921
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95487586
82SA1_27219007_Chip-Seq_Bcells_Human0.95369559
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95312672
84BCL6_27268052_Chip-Seq_Bcells_Human0.94126071
85GATA1_26923725_Chip-Seq_HPCs_Mouse0.92797248
86LXR_22292898_ChIP-Seq_THP-1_Human0.92508589
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91982755
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90917245
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90870861
90BCOR_27268052_Chip-Seq_Bcells_Human0.90538118
91TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90265828
92GATA1_19941826_ChIP-Seq_K562_Human0.90080640
93GATA3_24758297_ChIP-Seq_MCF-7_Human0.90014697
94GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89379307
95FOXA1_25552417_ChIP-Seq_VCAP_Human0.88270729
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87716899
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87091578
98CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86740764
99VDR_24763502_ChIP-Seq_THP-1_Human0.86177473
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85687755
101P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85305731
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85266430
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85245835
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85223032
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85029338
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84308457
107CDX2_22108803_ChIP-Seq_LS180_Human0.83224584
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.82379370
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.82296866
110AR_21909140_ChIP-Seq_LNCAP_Human0.82213587
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82140440
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81633337
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81355341
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81222614
115DROSHA_22980978_ChIP-Seq_HELA_Human0.80322932
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79860446
117SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79739881
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79056222
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78539674
120NANOG_20526341_ChIP-Seq_ESCs_Human0.78332619
121* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78210482
122RXR_22108803_ChIP-Seq_LS180_Human0.78083294
123TP63_22573176_ChIP-Seq_HFKS_Human0.77169872
124BCAT_22108803_ChIP-Seq_LS180_Human0.77084329
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75838523
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75394624
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.74839587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.55207308
2MP0010234_abnormal_vibrissa_follicle6.31909152
3MP0001666_abnormal_nutrient_absorption5.47087767
4MP0004264_abnormal_extraembryonic_tissu3.97524974
5MP0003866_abnormal_defecation3.48640738
6MP0000462_abnormal_digestive_system3.35477621
7MP0009840_abnormal_foam_cell3.31144848
8MP0005085_abnormal_gallbladder_physiolo3.10916866
9MP0003183_abnormal_peptide_metabolism2.94558783
10MP0002139_abnormal_hepatobiliary_system2.86983811
11MP0003252_abnormal_bile_duct2.76241470
12MP0008875_abnormal_xenobiotic_pharmacok2.70717648
13MP0001873_stomach_inflammation2.65717404
14MP0002822_catalepsy2.46062585
15MP0001663_abnormal_digestive_system2.43464510
16MP0005381_digestive/alimentary_phenotyp2.34413613
17MP0001664_abnormal_digestion2.31016523
18MP0010329_abnormal_lipoprotein_level2.25051032
19MP0010155_abnormal_intestine_physiology2.24129804
20MP0000537_abnormal_urethra_morphology2.19106435
21MP0005377_hearing/vestibular/ear_phenot2.17871026
22MP0003878_abnormal_ear_physiology2.17871026
23MP0005409_darkened_coat_color2.00904750
24MP0003705_abnormal_hypodermis_morpholog1.96523364
25MP0005365_abnormal_bile_salt1.93336952
26MP0000477_abnormal_intestine_morphology1.92326110
27MP0010352_gastrointestinal_tract_polyps1.84405080
28MP0004147_increased_porphyrin_level1.82867851
29MP0000490_abnormal_crypts_of1.82323703
30MP0004019_abnormal_vitamin_homeostasis1.74455686
31MP0006054_spinal_hemorrhage1.68723167
32MP0000538_abnormal_urinary_bladder1.61224701
33MP0005670_abnormal_white_adipose1.58699736
34MP0003300_gastrointestinal_ulcer1.56401203
35MP0004043_abnormal_pH_regulation1.56173560
36MP0002796_impaired_skin_barrier1.53819142
37MP0005084_abnormal_gallbladder_morpholo1.49472348
38MP0008004_abnormal_stomach_pH1.44973221
39MP0010678_abnormal_skin_adnexa1.44360240
40MP0003191_abnormal_cellular_cholesterol1.42277517
41MP0004858_abnormal_nervous_system1.40508173
42MP0005167_abnormal_blood-brain_barrier1.37921131
43MP0000465_gastrointestinal_hemorrhage1.30371425
44MP0002138_abnormal_hepatobiliary_system1.29556170
45MP0003806_abnormal_nucleotide_metabolis1.25390388
46MP0001764_abnormal_homeostasis1.24860600
47MP0003283_abnormal_digestive_organ1.23738205
48MP0001849_ear_inflammation1.22718166
49MP0001188_hyperpigmentation1.22592113
50MP0009643_abnormal_urine_homeostasis1.15660103
51MP0003724_increased_susceptibility_to1.15440785
52MP0005448_abnormal_energy_balance1.12917061
53MP0002254_reproductive_system_inflammat1.12165605
54MP0004947_skin_inflammation1.09062555
55MP0002876_abnormal_thyroid_physiology1.08995034
56MP0002166_altered_tumor_susceptibility1.08620048
57MP0000467_abnormal_esophagus_morphology1.04006091
58MP0003453_abnormal_keratinocyte_physiol1.03465029
59MP0001765_abnormal_ion_homeostasis1.02454012
60MP0005166_decreased_susceptibility_to1.00044479
61MP0005501_abnormal_skin_physiology0.98703421
62MP0003303_peritoneal_inflammation0.97962894
63MP0000230_abnormal_systemic_arterial0.96038430
64MP0009379_abnormal_foot_pigmentation0.95916028
65MP0002089_abnormal_postnatal_growth/wei0.94924224
66MP0002118_abnormal_lipid_homeostasis0.94388959
67MP0009053_abnormal_anal_canal0.93426054
68MP0000470_abnormal_stomach_morphology0.93046389
69MP0005332_abnormal_amino_acid0.92884136
70MP0002009_preneoplasia0.91784941
71MP0003868_abnormal_feces_composition0.90080668
72MP0001501_abnormal_sleep_pattern0.89215622
73MP0000609_abnormal_liver_physiology0.89156039
74MP0002098_abnormal_vibrissa_morphology0.86494087
75MP0005367_renal/urinary_system_phenotyp0.83798462
76MP0000516_abnormal_urinary_system0.83798462
77MP0005636_abnormal_mineral_homeostasis0.83538451
78MP0000566_synostosis0.82535223
79MP0009384_cardiac_valve_regurgitation0.82475359
80MP0002971_abnormal_brown_adipose0.82076590
81MP0005025_abnormal_response_to0.81649816
82MP0002006_tumorigenesis0.80756601
83MP0008872_abnormal_physiological_respon0.77674760
84MP0001216_abnormal_epidermal_layer0.75487290
85MP0005666_abnormal_adipose_tissue0.75006224
86MP0006082_CNS_inflammation0.74458892
87MP0002896_abnormal_bone_mineralization0.74345881
88MP0005165_increased_susceptibility_to0.71562412
89MP0005387_immune_system_phenotype0.70626740
90MP0001790_abnormal_immune_system0.70626740
91MP0009115_abnormal_fat_cell0.70160237
92MP0003329_amyloid_beta_deposits0.68526231
93MP0002136_abnormal_kidney_physiology0.68088794
94MP0009697_abnormal_copulation0.67729747
95MP0005310_abnormal_salivary_gland0.67554731
96MP0003436_decreased_susceptibility_to0.67032662
97MP0001485_abnormal_pinna_reflex0.64920168
98MP0009333_abnormal_splenocyte_physiolog0.64035168
99MP0003315_abnormal_perineum_morphology0.62773641
100MP0008469_abnormal_protein_level0.62536269
101MP0001835_abnormal_antigen_presentation0.62473599
102MP0005535_abnormal_body_temperature0.62428423
103MP0004270_analgesia0.62406632
104MP0003879_abnormal_hair_cell0.61368624
105MP0005319_abnormal_enzyme/_coenzyme0.61140334
106MP0005266_abnormal_metabolism0.58649802
107MP0002277_abnormal_respiratory_mucosa0.58479024
108MP0005058_abnormal_lysosome_morphology0.57062073
109MP0005023_abnormal_wound_healing0.56795904
110MP0009780_abnormal_chondrocyte_physiolo0.55562443
111MP0000249_abnormal_blood_vessel0.55237795
112MP0005451_abnormal_body_composition0.54349993
113MP0003718_maternal_effect0.51930725
114MP0001533_abnormal_skeleton_physiology0.51842916
115MP0004782_abnormal_surfactant_physiolog0.51831843
116MP0002060_abnormal_skin_morphology0.50153467
117MP0000678_abnormal_parathyroid_gland0.49607265
118MP0000383_abnormal_hair_follicle0.49552093
119MP0009785_altered_susceptibility_to0.48949698
120MP0009642_abnormal_blood_homeostasis0.48098910
121MP0000604_amyloidosis0.47506141
122MP0000377_abnormal_hair_follicle0.44962323
123MP0001845_abnormal_inflammatory_respons0.44343816
124MP0003638_abnormal_response/metabolism_0.44172846
125MP0000613_abnormal_salivary_gland0.43829889
126MP0008873_increased_physiological_sensi0.43479101
127MP0010771_integument_phenotype0.43294102
128MP0005584_abnormal_enzyme/coenzyme_acti0.42850689
129MP0003950_abnormal_plasma_membrane0.42028759
130MP0003045_fibrosis0.41636520
131MP0002234_abnormal_pharynx_morphology0.40350331
132MP0001756_abnormal_urination0.40326470
133MP0001191_abnormal_skin_condition0.39710769
134MP0001881_abnormal_mammary_gland0.38448820

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.18064624
2Right ventricular cardiomyopathy (HP:0011663)6.69810283
3Abnormality of glutamine family amino acid metabolism (HP:0010902)6.10184152
4Decreased circulating renin level (HP:0003351)5.68488034
5Malnutrition (HP:0004395)5.51004176
6Acanthocytosis (HP:0001927)5.30759132
7Hydroxyprolinuria (HP:0003080)5.14630396
8Abnormality of proline metabolism (HP:0010907)5.14630396
9Hypobetalipoproteinemia (HP:0003563)5.13108560
10Cupped ribs (HP:0000887)4.58213565
11Conjugated hyperbilirubinemia (HP:0002908)4.51533226
12Alkalosis (HP:0001948)4.51428515
13Abdominal distention (HP:0003270)4.46664731
14Autoimmune thrombocytopenia (HP:0001973)4.42957556
15Flat acetabular roof (HP:0003180)4.29150413
16Chronic diarrhea (HP:0002028)4.06997784
17Hyperaldosteronism (HP:0000859)3.66847565
18Fat malabsorption (HP:0002630)3.62422296
19Systemic lupus erythematosus (HP:0002725)3.62090909
20Hyperactive renin-angiotensin system (HP:0000841)3.52295971
21Milia (HP:0001056)3.37569145
22Gastrointestinal dysmotility (HP:0002579)3.32931937
23Autoimmune hemolytic anemia (HP:0001890)3.32517595
24Abnormal tarsal ossification (HP:0008369)3.27033644
25Abnormality of small intestinal villus morphology (HP:0011472)3.26146777
26Villous atrophy (HP:0011473)3.26146777
27Pigmentary retinal degeneration (HP:0001146)3.25628950
28Hypolipoproteinemia (HP:0010981)3.24150780
29Fragile nails (HP:0001808)3.24094521
30Hemorrhage of the eye (HP:0011885)3.23690870
31Woolly hair (HP:0002224)3.20152690
32Dehydration (HP:0001944)3.15377837
33Poikilocytosis (HP:0004447)3.11904484
34Widely patent fontanelles and sutures (HP:0004492)3.08852525
35Mildly elevated creatine phosphokinase (HP:0008180)3.04945670
36Abnormality of the 1st metacarpal (HP:0010009)2.98685721
37Confusion (HP:0001289)2.95251970
38Palpitations (HP:0001962)2.92250537
39Hyponatremia (HP:0002902)2.91290320
40Pustule (HP:0200039)2.87440781
41Potter facies (HP:0002009)2.84068706
42Facial shape deformation (HP:0011334)2.84068706
43Hypokalemia (HP:0002900)2.83680444
44Eczematoid dermatitis (HP:0000976)2.80874669
45Atrophic scars (HP:0001075)2.75576146
46Abnormality of chloride homeostasis (HP:0011422)2.74469653
47Micronodular cirrhosis (HP:0001413)2.69445710
48Mesangial abnormality (HP:0001966)2.69404016
49Progressive sensorineural hearing impairment (HP:0000408)2.66965039
50Onycholysis (HP:0001806)2.64629652
51Intrahepatic cholestasis (HP:0001406)2.63960371
52Abnormality of potassium homeostasis (HP:0011042)2.61489036
53Pili torti (HP:0003777)2.61104852
54Xanthomatosis (HP:0000991)2.58721883
55Abnormal biliary tract morphology (HP:0012440)2.58135137
56Metabolic alkalosis (HP:0200114)2.58116126
57Increased IgE level (HP:0003212)2.53354896
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.52750662
59Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52294300
60Syncope (HP:0001279)2.49727425
61Hyperglycinuria (HP:0003108)2.49412926
62Hyperammonemia (HP:0001987)2.48250582
63Abnormality of the gastric mucosa (HP:0004295)2.47586987
64Abnormal foot bone ossification (HP:0010675)2.46671282
65Abnormality of the distal phalanx of the thumb (HP:0009617)2.46649708
66Abnormality of the vitamin B12 metabolism (HP:0004341)2.45754557
67Goiter (HP:0000853)2.40725990
68Alopecia of scalp (HP:0002293)2.40331664
69Abnormality of carpal bone ossification (HP:0006257)2.35601901
70Hypotension (HP:0002615)2.34662651
71Nausea (HP:0002018)2.33845205
72Rectal prolapse (HP:0002035)2.32680179
73Plantar hyperkeratosis (HP:0007556)2.31808401
74Glycosuria (HP:0003076)2.31453580
75Abnormality of urine glucose concentration (HP:0011016)2.31453580
76Neonatal short-limb short stature (HP:0008921)2.28955106
77Progressive hearing impairment (HP:0001730)2.28570862
78Proximal tubulopathy (HP:0000114)2.28000867
79Abnormality of vitamin B metabolism (HP:0004340)2.27931169
80Renal tubular acidosis (HP:0001947)2.23567709
81Nephrolithiasis (HP:0000787)2.20993971
82Abnormality of purine metabolism (HP:0004352)2.19880688
83Biliary tract neoplasm (HP:0100574)2.16190903
84Abnormality of sodium homeostasis (HP:0010931)2.15740243
85Visceral angiomatosis (HP:0100761)2.13657816
86Hypophosphatemia (HP:0002148)2.10077354
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09879241
88Dicarboxylic aciduria (HP:0003215)2.09879241
89Abnormal glucose tolerance (HP:0001952)2.09117714
90Congenital sensorineural hearing impairment (HP:0008527)2.09024583
91Increased mean platelet volume (HP:0011877)2.08860063
92Fragile skin (HP:0001030)2.08334207
93Adrenal overactivity (HP:0002717)2.08246025
94Curly hair (HP:0002212)2.07506422
95Enlarged epiphyses (HP:0010580)2.07160213
96Hypercholesterolemia (HP:0003124)2.07089089
97Ureteral stenosis (HP:0000071)2.06534944
98Abnormality of serine family amino acid metabolism (HP:0010894)2.06417475
99Abnormality of glycine metabolism (HP:0010895)2.06417475
100Cerebral palsy (HP:0100021)2.05528737
101Hyperphosphatemia (HP:0002905)2.04221550
102Glomerulonephritis (HP:0000099)2.03317909
103Increased purine levels (HP:0004368)2.03215134
104Hyperuricemia (HP:0002149)2.03215134
105Reticulocytosis (HP:0001923)2.03005546
106Abnormality of complement system (HP:0005339)2.01408761
107Abnormal hair laboratory examination (HP:0003328)2.00556032
108Focal segmental glomerulosclerosis (HP:0000097)2.00360984
109Hyperparathyroidism (HP:0000843)2.00262049
110Hyperkalemia (HP:0002153)1.99875014
111Abnormality of vitamin metabolism (HP:0100508)1.99728799
112Posterior subcapsular cataract (HP:0007787)1.99377997
113Myopathic facies (HP:0002058)1.98982652
114Protuberant abdomen (HP:0001538)1.98822631
115Steatorrhea (HP:0002570)1.98120374
116Hoarse voice (HP:0001609)1.97299733
117Delayed epiphyseal ossification (HP:0002663)1.95976836
118Abnormality of B cell number (HP:0010975)1.95198843
119B lymphocytopenia (HP:0010976)1.95198843
120Short phalanx of the thumb (HP:0009660)1.94562608
121Glomerulosclerosis (HP:0000096)1.92855572
122Ureteral obstruction (HP:0006000)1.92723978
123Cone-rod dystrophy (HP:0000548)1.92481639
124Flat capital femoral epiphysis (HP:0003370)1.92479608
125Severe combined immunodeficiency (HP:0004430)1.91952790
126Polycythemia (HP:0001901)1.91459409
127Nephritis (HP:0000123)1.91332355
128Flattened epiphyses (HP:0003071)1.91260196
129Growth hormone excess (HP:0000845)1.91249689
130Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90714312
131Abnormality of the costochondral junction (HP:0000919)1.90682972
132Abnormal albumin level (HP:0012116)1.87713899
133Hypoalbuminemia (HP:0003073)1.87713899
134Wide cranial sutures (HP:0010537)1.87382661
135Esophageal varix (HP:0002040)1.86925905
136Combined immunodeficiency (HP:0005387)1.86225472
137Ventricular tachycardia (HP:0004756)1.86220261
138Thin bony cortex (HP:0002753)1.86056360
139Hemangiomatosis (HP:0007461)1.85125318
140Pancreatitis (HP:0001733)1.84712755
141Complement deficiency (HP:0004431)1.84144297
142Bone pain (HP:0002653)1.84055694
143Abnormality of renin-angiotensin system (HP:0000847)1.83094837
144Abnormality of sulfur amino acid metabolism (HP:0004339)1.81781466
145Metabolic acidosis (HP:0001942)1.81113099
146Hypoplasia of dental enamel (HP:0006297)1.80288908
147Symptomatic seizures (HP:0011145)1.80096482
148Epidermoid cyst (HP:0200040)1.79732144
149Petechiae (HP:0000967)1.78524588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.27610172
2FRK5.84705808
3MST45.44075162
4MST1R4.70024168
5LMTK24.55432220
6PRKG23.23387517
7EPHA22.96938297
8MAP2K22.86358116
9NME12.72388917
10GRK62.69214611
11STK392.68419490
12EPHB22.64935806
13PIK3CA2.51492817
14RIPK12.50912286
15TESK12.31839355
16MAP3K22.18503557
17PTK62.15981797
18MYLK1.95786326
19MAP3K101.86521415
20OXSR11.82912669
21FGFR41.74813787
22MET1.67984436
23AKT31.55506166
24TAOK31.50073772
25ERN11.47317877
26TESK21.38835905
27KSR21.36731791
28NUAK11.35611472
29STK101.34671067
30ERBB41.32728691
31EPHA31.29212242
32TAOK11.28286898
33PRPF4B1.23254254
34PTK21.17821308
35MAP2K11.15498496
36PRKCI1.15336902
37FER1.12534242
38DDR21.04856130
39LIMK11.03926918
40RIPK40.99353210
41TNIK0.94071050
42PAK40.93868383
43TTK0.92783949
44EPHB10.92717089
45MATK0.92563159
46MAP3K80.91118815
47FGFR30.90195060
48MAP4K10.89237587
49MAP3K90.84545746
50ERBB20.81093023
51MAP2K60.80181144
52BMX0.80053327
53MAP3K70.78288621
54PBK0.76621017
55DMPK0.75683001
56LATS10.75158208
57CAMK2D0.73920389
58PRKAA20.71635941
59LRRK20.66211550
60MAP3K10.65640117
61NLK0.62501264
62IRAK10.61731270
63PKN20.61691187
64MAP3K110.57345330
65PDPK10.56158450
66ABL20.54195018
67MAP3K120.54144060
68EPHA40.52396120
69IRAK30.52280804
70ICK0.51597271
71CASK0.49219349
72TBK10.48834838
73PAK30.47535497
74SIK10.47372999
75CAMK2G0.47165561
76MAPK110.47124948
77PAK20.45386848
78MAP3K30.44542472
79BMPR20.44284780
80CAMK2B0.43866233
81PAK10.43287484
82RET0.40729508
83SRC0.40453648
84JAK10.40009552
85SMG10.39907093
86SCYL20.39743841
87CSK0.37175541
88PIM20.36239283
89YES10.34975475
90PRKAA10.34874879
91IRAK40.33213273
92TRIB30.33054304
93ZAP700.32648194
94PDK10.32481383
95AURKB0.32459901
96ROCK10.32261721
97JAK20.32141445
98IKBKE0.29608484
99STK30.29299143
100PRKCZ0.28772852
101ARAF0.27725867
102DYRK1B0.27077553
103PDK20.24807430
104* PRKCA0.24508260
105WNK40.23561731
106FYN0.23151067
107CDK190.22639763
108GRK10.21444148
109CSNK1A10.20807449
110GSK3A0.20772554
111MAP3K130.20568097
112LYN0.20321579
113ITK0.19069201
114CDK60.19035194
115PIM10.18874371
116MAP3K140.18052627
117RPS6KA20.18024796
118STK240.17934703
119CSF1R0.17196394
120PRKCD0.17133536
121PRKACG0.17001902
122EEF2K0.16519433
123RPS6KB20.15851527
124TYK20.15835854
125AKT20.15724610
126IGF1R0.15560430
127PRKCQ0.15106924
128CDC42BPA0.15098481
129NEK60.14661102
130PDGFRA0.14172294
131FGFR10.13717799
132JAK30.12587593
133DAPK30.12415388
134MELK0.11185811

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.51607714
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.39496817
3Mineral absorption_Homo sapiens_hsa049784.21437071
4Renin-angiotensin system_Homo sapiens_hsa046143.98187068
5Sulfur metabolism_Homo sapiens_hsa009203.75116161
6Vitamin digestion and absorption_Homo sapiens_hsa049773.46285851
7Caffeine metabolism_Homo sapiens_hsa002322.61947643
8Galactose metabolism_Homo sapiens_hsa000522.61746084
9Bile secretion_Homo sapiens_hsa049762.30617136
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.25355290
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.23336940
12Starch and sucrose metabolism_Homo sapiens_hsa005002.19700106
13Protein digestion and absorption_Homo sapiens_hsa049742.05889847
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.02941549
15Histidine metabolism_Homo sapiens_hsa003401.93168973
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.87771965
17Fructose and mannose metabolism_Homo sapiens_hsa000511.87173533
18Folate biosynthesis_Homo sapiens_hsa007901.80020071
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.79674092
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68728727
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.55346643
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.48224689
23PPAR signaling pathway_Homo sapiens_hsa033201.43336877
24Glutathione metabolism_Homo sapiens_hsa004801.42797844
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25655249
26Tryptophan metabolism_Homo sapiens_hsa003801.22400589
27Glycerolipid metabolism_Homo sapiens_hsa005611.21796379
28Sphingolipid metabolism_Homo sapiens_hsa006001.08029276
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.06319515
30Fatty acid degradation_Homo sapiens_hsa000711.05675707
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03747149
32Asthma_Homo sapiens_hsa053101.02990673
33Arginine biosynthesis_Homo sapiens_hsa002200.96782829
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96604018
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95606122
36Tight junction_Homo sapiens_hsa045300.92273511
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91175150
38Thyroid hormone synthesis_Homo sapiens_hsa049180.89877021
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88389262
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83935612
41Pancreatic secretion_Homo sapiens_hsa049720.80438562
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80418491
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79702886
44Allograft rejection_Homo sapiens_hsa053300.77743444
45Arginine and proline metabolism_Homo sapiens_hsa003300.74803006
46Other glycan degradation_Homo sapiens_hsa005110.74288185
47ABC transporters_Homo sapiens_hsa020100.72965849
48Chemical carcinogenesis_Homo sapiens_hsa052040.72258029
49Autoimmune thyroid disease_Homo sapiens_hsa053200.72133464
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.71656887
51Graft-versus-host disease_Homo sapiens_hsa053320.67876854
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66751300
53Nitrogen metabolism_Homo sapiens_hsa009100.66699158
54Linoleic acid metabolism_Homo sapiens_hsa005910.65774978
55Pyruvate metabolism_Homo sapiens_hsa006200.62531960
56Staphylococcus aureus infection_Homo sapiens_hsa051500.62437947
57Gastric acid secretion_Homo sapiens_hsa049710.58749430
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.58214304
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.56428818
60Carbon metabolism_Homo sapiens_hsa012000.56044650
61Pentose phosphate pathway_Homo sapiens_hsa000300.56025170
62beta-Alanine metabolism_Homo sapiens_hsa004100.54707768
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53320142
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52895616
65Salmonella infection_Homo sapiens_hsa051320.52616405
66Bladder cancer_Homo sapiens_hsa052190.49990813
67Type I diabetes mellitus_Homo sapiens_hsa049400.49504785
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46794650
69Arachidonic acid metabolism_Homo sapiens_hsa005900.46672068
70Adherens junction_Homo sapiens_hsa045200.46204301
71Thyroid cancer_Homo sapiens_hsa052160.45408861
72African trypanosomiasis_Homo sapiens_hsa051430.45314914
73Butanoate metabolism_Homo sapiens_hsa006500.43472207
74Phenylalanine metabolism_Homo sapiens_hsa003600.42820239
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.41905658
76Tyrosine metabolism_Homo sapiens_hsa003500.41027233
77Retinol metabolism_Homo sapiens_hsa008300.40649723
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39328863
79Hepatitis C_Homo sapiens_hsa051600.38653790
80Salivary secretion_Homo sapiens_hsa049700.37554096
81Antigen processing and presentation_Homo sapiens_hsa046120.34468184
82Fatty acid metabolism_Homo sapiens_hsa012120.34151631
83Ether lipid metabolism_Homo sapiens_hsa005650.33552572
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.33471097
85Leishmaniasis_Homo sapiens_hsa051400.33189210
86Type II diabetes mellitus_Homo sapiens_hsa049300.31710843
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29755558
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28952074
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.25742353
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25015613
91Metabolic pathways_Homo sapiens_hsa011000.24891270
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22777960
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21824093
94Steroid biosynthesis_Homo sapiens_hsa001000.21122354
95Vibrio cholerae infection_Homo sapiens_hsa051100.20342713
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.19567391
97Sulfur relay system_Homo sapiens_hsa041220.19322235
98Fatty acid biosynthesis_Homo sapiens_hsa000610.17786377
99GnRH signaling pathway_Homo sapiens_hsa049120.17614892
100Renin secretion_Homo sapiens_hsa049240.17480231
101Peroxisome_Homo sapiens_hsa041460.17467049
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17060290
103Propanoate metabolism_Homo sapiens_hsa006400.16900262
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15898386
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15638287
106Amoebiasis_Homo sapiens_hsa051460.14966278
107Viral myocarditis_Homo sapiens_hsa054160.14632247
108Biosynthesis of amino acids_Homo sapiens_hsa012300.13127215
109Insulin secretion_Homo sapiens_hsa049110.10110408
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.09520304
111Selenocompound metabolism_Homo sapiens_hsa004500.08583592
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.08509609
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.08341203
114Toxoplasmosis_Homo sapiens_hsa051450.06952689
115Influenza A_Homo sapiens_hsa051640.06917833
116Pertussis_Homo sapiens_hsa051330.06822373
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.05184639
118Insulin resistance_Homo sapiens_hsa049310.04328073
119Inositol phosphate metabolism_Homo sapiens_hsa005620.04148150
120Tuberculosis_Homo sapiens_hsa051520.04010040
121Glucagon signaling pathway_Homo sapiens_hsa049220.03019076
122Cocaine addiction_Homo sapiens_hsa050300.02738252

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