KRT222

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.98072687
2glutamate secretion (GO:0014047)5.44784416
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.39241596
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.38501012
5vocalization behavior (GO:0071625)5.29304172
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.24802459
7regulation of synaptic vesicle exocytosis (GO:2000300)5.10114616
8neuronal action potential propagation (GO:0019227)5.03775092
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.97582041
10synaptic vesicle maturation (GO:0016188)4.83103045
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.65987829
12locomotory exploration behavior (GO:0035641)4.61721340
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.61471707
14regulation of glutamate receptor signaling pathway (GO:1900449)4.57461597
15regulation of synaptic vesicle transport (GO:1902803)4.55418727
16protein localization to synapse (GO:0035418)4.54786566
17neurotransmitter secretion (GO:0007269)4.52858029
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.49550575
19neurotransmitter-gated ion channel clustering (GO:0072578)4.40668337
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.38946900
21neuron cell-cell adhesion (GO:0007158)4.38224177
22negative regulation of synaptic transmission, GABAergic (GO:0032229)4.35956663
23neuron-neuron synaptic transmission (GO:0007270)4.24148418
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.13452161
25synaptic transmission, glutamatergic (GO:0035249)4.12753862
26glutamate receptor signaling pathway (GO:0007215)4.06976401
27presynaptic membrane assembly (GO:0097105)3.97321534
28serotonin metabolic process (GO:0042428)3.84396057
29presynaptic membrane organization (GO:0097090)3.82109123
30long-term synaptic potentiation (GO:0060291)3.79922376
31regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.79811147
32cerebellar Purkinje cell layer development (GO:0021680)3.78323973
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71290380
34cerebellar Purkinje cell differentiation (GO:0021702)3.71100686
35neurotransmitter transport (GO:0006836)3.64834737
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.63803419
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.62443391
38positive regulation of synapse maturation (GO:0090129)3.61815696
39positive regulation of membrane potential (GO:0045838)3.58928607
40regulation of neuronal synaptic plasticity (GO:0048168)3.58378994
41exploration behavior (GO:0035640)3.57846964
42detection of calcium ion (GO:0005513)3.55686175
43gamma-aminobutyric acid transport (GO:0015812)3.54370427
44regulation of postsynaptic membrane potential (GO:0060078)3.53878935
45cellular potassium ion homeostasis (GO:0030007)3.53036586
46synaptic vesicle endocytosis (GO:0048488)3.52170844
47regulation of neurotransmitter secretion (GO:0046928)3.51485851
48potassium ion homeostasis (GO:0055075)3.49883718
49response to histamine (GO:0034776)3.49814657
50postsynaptic membrane organization (GO:0001941)3.49333511
51regulation of synapse structural plasticity (GO:0051823)3.49041679
52membrane depolarization during action potential (GO:0086010)3.48642448
53G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.47199193
54long-term memory (GO:0007616)3.45026113
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44029790
56energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.42452180
57ATP hydrolysis coupled proton transport (GO:0015991)3.42452180
58primary amino compound metabolic process (GO:1901160)3.42193683
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38430598
60neuromuscular process controlling posture (GO:0050884)3.38116562
61behavioral response to cocaine (GO:0048148)3.37404108
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.36876159
63regulation of neurotransmitter levels (GO:0001505)3.36105630
64regulation of voltage-gated calcium channel activity (GO:1901385)3.36045320
65sodium ion export (GO:0071436)3.35855509
66transferrin transport (GO:0033572)3.34476995
67regulation of synaptic plasticity (GO:0048167)3.34246668
68positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.32760851
69positive regulation of neurotransmitter transport (GO:0051590)3.32184118
70regulation of neurotransmitter transport (GO:0051588)3.32100824
71neurofilament cytoskeleton organization (GO:0060052)3.31911118
72startle response (GO:0001964)3.29633875
73regulation of vesicle fusion (GO:0031338)3.29615238
74membrane depolarization (GO:0051899)3.24327724
75long term synaptic depression (GO:0060292)3.23186577
76striatum development (GO:0021756)3.23179358
77short-term memory (GO:0007614)3.20647667
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17685339
79regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.17578907
80proline transport (GO:0015824)3.16508733
81activation of protein kinase A activity (GO:0034199)3.13676610
82potassium ion import (GO:0010107)3.13094878
83synaptic transmission (GO:0007268)3.13090520
84dendritic spine morphogenesis (GO:0060997)3.12359582
85negative regulation of dendrite morphogenesis (GO:0050774)3.11877504
86trivalent inorganic cation transport (GO:0072512)3.11464557
87ferric iron transport (GO:0015682)3.11464557
88prepulse inhibition (GO:0060134)3.09880627
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.08799549
90dopamine biosynthetic process (GO:0042416)3.07756686
91positive regulation of synaptic transmission (GO:0050806)3.07333943
92membrane hyperpolarization (GO:0060081)3.07119731
93positive regulation of dendritic spine morphogenesis (GO:0061003)3.06576113
94cerebellar granule cell differentiation (GO:0021707)3.04995717
95C4-dicarboxylate transport (GO:0015740)3.04989840
96regulation of cell communication by electrical coupling (GO:0010649)3.04948002
97positive regulation of dendritic spine development (GO:0060999)3.04748231
98positive regulation of neurotransmitter secretion (GO:0001956)3.04697241
99regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.03562796
100cellular ketone body metabolic process (GO:0046950)3.02438570
101positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02178548
102regulation of synapse maturation (GO:0090128)3.01728999
103transmission of nerve impulse (GO:0019226)3.01270239
104regulation of dendritic spine development (GO:0060998)3.00971821
105negative regulation of cytosolic calcium ion concentration (GO:0051481)3.00252692
106alanine transport (GO:0032328)2.99023743
107righting reflex (GO:0060013)2.98195425
108regulation of calcium ion-dependent exocytosis (GO:0017158)2.96120156
109cell communication by electrical coupling (GO:0010644)2.94003146
110establishment of synaptic vesicle localization (GO:0097480)2.93473548
111synaptic vesicle transport (GO:0048489)2.93473548
112regulation of synaptic transmission (GO:0050804)2.92994196
113cell differentiation in hindbrain (GO:0021533)2.92992978
114regulation of synaptic transmission, GABAergic (GO:0032228)2.92125526
115cellular sodium ion homeostasis (GO:0006883)2.92119350
116mechanosensory behavior (GO:0007638)2.91130581
117positive regulation of potassium ion transmembrane transport (GO:1901381)2.90188904
118response to amphetamine (GO:0001975)2.90032514
119learning (GO:0007612)2.89853993
120layer formation in cerebral cortex (GO:0021819)2.87570394
121regulation of dendritic spine morphogenesis (GO:0061001)2.87098869
122positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.86671516
123chemosensory behavior (GO:0007635)2.84048207
124innervation (GO:0060384)2.83733857
125positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.81011037
126insulin secretion (GO:0030073)2.80369266
127calcium ion-dependent exocytosis (GO:0017156)2.79947188
128signal release (GO:0023061)2.75716798
129neuronal action potential (GO:0019228)2.75146865
130regulation of dopamine metabolic process (GO:0042053)2.74484644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.70833339
2GBX2_23144817_ChIP-Seq_PC3_Human4.45202641
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14307149
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02713975
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88772026
6REST_21632747_ChIP-Seq_MESCs_Mouse2.74849606
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51970553
8TAF15_26573619_Chip-Seq_HEK293_Human2.51667456
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47507373
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47507373
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44409490
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39097199
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36694305
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.34788219
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34469062
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33312404
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.28098932
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.26635306
19DROSHA_22980978_ChIP-Seq_HELA_Human2.23641338
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14833456
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.14326675
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06293327
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06105007
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04780900
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01869306
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.99587322
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98688658
28SMAD4_21799915_ChIP-Seq_A2780_Human1.97060138
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.95489430
30* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89250364
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88179858
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88078799
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83327251
34AR_21572438_ChIP-Seq_LNCaP_Human1.80370591
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79602972
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79019160
37P300_19829295_ChIP-Seq_ESCs_Human1.71854107
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67470868
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.65507676
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63767427
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63521200
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58389650
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58241837
44VDR_22108803_ChIP-Seq_LS180_Human1.55180894
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48478704
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47847320
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.46886827
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46884364
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43969896
50* AR_25329375_ChIP-Seq_VCAP_Human1.43865377
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.43002437
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42624842
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42529987
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42373949
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.41805671
56STAT3_23295773_ChIP-Seq_U87_Human1.37883297
57FUS_26573619_Chip-Seq_HEK293_Human1.33372008
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32009081
59TCF4_23295773_ChIP-Seq_U87_Human1.30626499
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.26318023
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25109349
62ZNF274_21170338_ChIP-Seq_K562_Hela1.23754164
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22087233
64* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21498818
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18465059
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18057272
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17862127
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17559731
69RNF2_27304074_Chip-Seq_NSC_Mouse1.16258443
70AR_19668381_ChIP-Seq_PC3_Human1.16071209
71HTT_18923047_ChIP-ChIP_STHdh_Human1.15674477
72* ER_23166858_ChIP-Seq_MCF-7_Human1.14116412
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12996567
74IGF1R_20145208_ChIP-Seq_DFB_Human1.12614826
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12405967
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.10697038
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10143394
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.09155330
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08946129
80RUNX2_22187159_ChIP-Seq_PCA_Human1.07877631
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.07832077
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.07645433
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.07432069
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06006573
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05940111
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05653816
87* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05495619
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05372675
89BCAT_22108803_ChIP-Seq_LS180_Human1.04573792
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.03897052
91JUN_21703547_ChIP-Seq_K562_Human1.03535202
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03415913
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.02995537
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.01731181
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01607432
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01351679
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00139584
98KDM2B_26808549_Chip-Seq_REH_Human0.99915327
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.99902512
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99668389
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99380722
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98563640
103SMAD4_21741376_ChIP-Seq_EPCs_Human0.98441265
104KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98419137
105* RING1B_27294783_Chip-Seq_ESCs_Mouse0.98413093
106EWS_26573619_Chip-Seq_HEK293_Human0.96282316
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96224342
108AHR_22903824_ChIP-Seq_MCF-7_Human0.95230292
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95063106
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95063106
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94206449
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94190821
113SOX9_26525672_Chip-Seq_HEART_Mouse0.92943387
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92475657
115P53_22387025_ChIP-Seq_ESCs_Mouse0.92440239
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91184218
117PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90610108
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90273350
119CBP_20019798_ChIP-Seq_JUKART_Human0.90174435

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.49028692
2MP0003880_abnormal_central_pattern5.01850954
3MP0003635_abnormal_synaptic_transmissio3.87121378
4MP0009046_muscle_twitch3.68295985
5MP0009745_abnormal_behavioral_response3.39863751
6MP0004270_analgesia3.31594841
7MP0002064_seizures3.21531521
8MP0001968_abnormal_touch/_nociception3.16812487
9MP0002063_abnormal_learning/memory/cond3.05616329
10MP0002272_abnormal_nervous_system2.79679210
11MP0002572_abnormal_emotion/affect_behav2.74858899
12MP0002822_catalepsy2.72297910
13MP0002736_abnormal_nociception_after2.67955933
14MP0002734_abnormal_mechanical_nocicepti2.63102163
15MP0002735_abnormal_chemical_nociception2.48219496
16MP0001486_abnormal_startle_reflex2.44775116
17MP0001501_abnormal_sleep_pattern2.41428461
18MP0002067_abnormal_sensory_capabilities2.21511195
19MP0002837_dystrophic_cardiac_calcinosis2.20210102
20MP0001440_abnormal_grooming_behavior2.04571134
21MP0008569_lethality_at_weaning1.96729771
22MP0005646_abnormal_pituitary_gland1.93048593
23MP0001970_abnormal_pain_threshold1.91539406
24MP0006276_abnormal_autonomic_nervous1.90437730
25MP0003879_abnormal_hair_cell1.88979454
26MP0002909_abnormal_adrenal_gland1.88844782
27MP0003787_abnormal_imprinting1.88593471
28MP0004924_abnormal_behavior1.86776964
29MP0005386_behavior/neurological_phenoty1.86776964
30MP0001529_abnormal_vocalization1.85148262
31MP0002733_abnormal_thermal_nociception1.85118102
32MP0001984_abnormal_olfaction1.82841041
33MP0005423_abnormal_somatic_nervous1.81041774
34MP0001188_hyperpigmentation1.76492904
35MP0000751_myopathy1.73881809
36MP0003646_muscle_fatigue1.72895569
37MP0004215_abnormal_myocardial_fiber1.68535782
38MP0002557_abnormal_social/conspecific_i1.65382722
39MP0002184_abnormal_innervation1.64253369
40MP0001905_abnormal_dopamine_level1.55098710
41MP0004142_abnormal_muscle_tone1.54400235
42MP0003123_paternal_imprinting1.49474266
43MP0009780_abnormal_chondrocyte_physiolo1.49169785
44MP0004811_abnormal_neuron_physiology1.48177305
45MP0003283_abnormal_digestive_organ1.47398917
46MP0002066_abnormal_motor_capabilities/c1.34616964
47MP0003121_genomic_imprinting1.33462452
48MP0003122_maternal_imprinting1.33310967
49MP0004145_abnormal_muscle_electrophysio1.29983120
50MP0005645_abnormal_hypothalamus_physiol1.25950501
51MP0010386_abnormal_urinary_bladder1.25641703
52MP0004484_altered_response_of1.23117507
53MP0000955_abnormal_spinal_cord1.22833573
54MP0001502_abnormal_circadian_rhythm1.22507798
55MP0002882_abnormal_neuron_morphology1.21844341
56MP0000778_abnormal_nervous_system1.19851219
57MP0004036_abnormal_muscle_relaxation1.19436116
58MP0003633_abnormal_nervous_system1.18714218
59MP0002876_abnormal_thyroid_physiology1.18269405
60MP0004085_abnormal_heartbeat1.15522749
61MP0005551_abnormal_eye_electrophysiolog1.11876938
62MP0000569_abnormal_digit_pigmentation1.11058948
63MP0004147_increased_porphyrin_level1.08815780
64MP0003329_amyloid_beta_deposits1.07039945
65MP0000013_abnormal_adipose_tissue1.06334152
66MP0004858_abnormal_nervous_system1.04671620
67MP0008872_abnormal_physiological_respon1.03689379
68MP0002229_neurodegeneration1.02559407
69MP0006072_abnormal_retinal_apoptosis0.98996422
70MP0004084_abnormal_cardiac_muscle0.98869130
71MP0008875_abnormal_xenobiotic_pharmacok0.98571199
72MP0003631_nervous_system_phenotype0.97539394
73MP0003137_abnormal_impulse_conducting0.96491952
74MP0005379_endocrine/exocrine_gland_phen0.96427966
75MP0005535_abnormal_body_temperature0.94648303
76MP0003690_abnormal_glial_cell0.94000773
77MP0008874_decreased_physiological_sensi0.93717325
78MP0002693_abnormal_pancreas_physiology0.93595177
79MP0003195_calcinosis0.89838265
80MP0004742_abnormal_vestibular_system0.89210965
81MP0002102_abnormal_ear_morphology0.88274395
82MP0001963_abnormal_hearing_physiology0.85918801
83MP0004233_abnormal_muscle_weight0.84718763
84MP0001944_abnormal_pancreas_morphology0.84670811
85MP0003011_delayed_dark_adaptation0.84191035
86MP0008877_abnormal_DNA_methylation0.84095073
87MP0004043_abnormal_pH_regulation0.83841506
88MP0002152_abnormal_brain_morphology0.83325486
89MP0002069_abnormal_eating/drinking_beha0.82043072
90MP0010234_abnormal_vibrissa_follicle0.81302139
91MP0000749_muscle_degeneration0.80612347
92MP0005448_abnormal_energy_balance0.79840411
93MP0002139_abnormal_hepatobiliary_system0.78481741
94MP0005620_abnormal_muscle_contractility0.77700995
95MP0000920_abnormal_myelination0.77291044
96MP0002972_abnormal_cardiac_muscle0.74128053
97MP0004885_abnormal_endolymph0.73954286
98MP0002090_abnormal_vision0.73710508
99MP0006035_abnormal_mitochondrial_morpho0.72316871
100MP0002078_abnormal_glucose_homeostasis0.71697665
101MP0000639_abnormal_adrenal_gland0.71148628
102MP0002638_abnormal_pupillary_reflex0.70364041
103MP0010329_abnormal_lipoprotein_level0.69042801
104MP0005332_abnormal_amino_acid0.68977536
105MP0005499_abnormal_olfactory_system0.68240351
106MP0005394_taste/olfaction_phenotype0.68240351
107MP0001664_abnormal_digestion0.67461191
108MP0001986_abnormal_taste_sensitivity0.67321293
109MP0005171_absent_coat_pigmentation0.67031249
110MP0004130_abnormal_muscle_cell0.66922154
111MP0002752_abnormal_somatic_nervous0.66544801
112MP0005253_abnormal_eye_physiology0.66188508
113MP0004510_myositis0.65249123
114MP0002332_abnormal_exercise_endurance0.63689633
115MP0006036_abnormal_mitochondrial_physio0.63663475
116MP0005409_darkened_coat_color0.62496301
117MP0001485_abnormal_pinna_reflex0.61972655
118MP0005636_abnormal_mineral_homeostasis0.60713912
119MP0001177_atelectasis0.59862247
120MP0000631_abnormal_neuroendocrine_gland0.58293529
121MP0005330_cardiomyopathy0.54875320
122MP0003634_abnormal_glial_cell0.54300377
123MP0003632_abnormal_nervous_system0.52923208
124MP0001943_abnormal_respiration0.52508626
125MP0008775_abnormal_heart_ventricle0.50515823

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.46626811
2Myokymia (HP:0002411)5.81323339
3Atonic seizures (HP:0010819)5.71061216
4Epileptic encephalopathy (HP:0200134)5.62267452
5Febrile seizures (HP:0002373)5.61650580
6Focal seizures (HP:0007359)5.39120865
7Absence seizures (HP:0002121)4.71568521
8Progressive cerebellar ataxia (HP:0002073)4.45617886
9Visual hallucinations (HP:0002367)4.41808152
10Dialeptic seizures (HP:0011146)4.19669048
11Generalized tonic-clonic seizures (HP:0002069)4.05201126
12Hyperventilation (HP:0002883)3.82650983
13Gaze-evoked nystagmus (HP:0000640)3.66204654
14Pheochromocytoma (HP:0002666)3.50638561
15Hypothermia (HP:0002045)3.30977240
16Broad-based gait (HP:0002136)3.29873187
17Action tremor (HP:0002345)3.16855312
18Dysmetric saccades (HP:0000641)3.14286278
19Intention tremor (HP:0002080)3.13686385
20Dysdiadochokinesis (HP:0002075)3.13563780
21Abnormal mitochondria in muscle tissue (HP:0008316)3.12274545
22Neuroendocrine neoplasm (HP:0100634)3.11812840
23Acute necrotizing encephalopathy (HP:0006965)3.11575291
24Impaired vibration sensation in the lower limbs (HP:0002166)3.04172121
25Ketoacidosis (HP:0001993)2.99807037
26Truncal ataxia (HP:0002078)2.99408673
27Poor eye contact (HP:0000817)2.93894164
28Progressive inability to walk (HP:0002505)2.93208096
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.88430425
30Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.88430425
31Progressive macrocephaly (HP:0004481)2.85413092
32Amblyopia (HP:0000646)2.84601912
33Anxiety (HP:0000739)2.81220642
34Abnormality of the corticospinal tract (HP:0002492)2.80252214
35Abnormal eating behavior (HP:0100738)2.78747675
36Scanning speech (HP:0002168)2.77999640
37Depression (HP:0000716)2.77219853
38Hyperinsulinemic hypoglycemia (HP:0000825)2.74063292
39Dysmetria (HP:0001310)2.72291671
40Epileptiform EEG discharges (HP:0011182)2.71335449
41Papilledema (HP:0001085)2.70543169
42Impaired social interactions (HP:0000735)2.69068638
43Abnormal social behavior (HP:0012433)2.69068638
44Abnormal hair whorl (HP:0010721)2.59905860
45Urinary bladder sphincter dysfunction (HP:0002839)2.59116005
46Impaired smooth pursuit (HP:0007772)2.55761796
47Hypoglycemic seizures (HP:0002173)2.51558509
48Ventricular fibrillation (HP:0001663)2.51228478
49Inability to walk (HP:0002540)2.50558316
50Postural instability (HP:0002172)2.48697278
51Postural tremor (HP:0002174)2.47315146
52EEG with generalized epileptiform discharges (HP:0011198)2.45275518
53Poor suck (HP:0002033)2.44733117
54Mitochondrial inheritance (HP:0001427)2.43972408
55Akinesia (HP:0002304)2.43735288
56Ankle clonus (HP:0011448)2.41444086
57Abnormality of aromatic amino acid family metabolism (HP:0004338)2.38518935
58Abnormality of binocular vision (HP:0011514)2.36636229
59Diplopia (HP:0000651)2.36636229
60Gait imbalance (HP:0002141)2.31204715
61Acute encephalopathy (HP:0006846)2.28374913
62Status epilepticus (HP:0002133)2.27959824
63Genetic anticipation (HP:0003743)2.27916884
64Hypoglycemic coma (HP:0001325)2.27820079
65Bundle branch block (HP:0011710)2.27332642
66Supranuclear gaze palsy (HP:0000605)2.24164153
67Fetal akinesia sequence (HP:0001989)2.23095190
68Impaired vibratory sensation (HP:0002495)2.23061893
69Bradykinesia (HP:0002067)2.22729858
70Sudden death (HP:0001699)2.22342008
71Syncope (HP:0001279)2.22190468
72Muscular hypotonia of the trunk (HP:0008936)2.22069110
73Increased CSF lactate (HP:0002490)2.21346804
74Drooling (HP:0002307)2.21344047
75Excessive salivation (HP:0003781)2.21344047
76Hypsarrhythmia (HP:0002521)2.20421996
77Polyphagia (HP:0002591)2.17983735
78Absent speech (HP:0001344)2.17454076
79Abnormality of ocular smooth pursuit (HP:0000617)2.17452874
80Exercise-induced myalgia (HP:0003738)2.16389341
81Failure to thrive in infancy (HP:0001531)2.16056147
82Congenital primary aphakia (HP:0007707)2.13075172
83Limb dystonia (HP:0002451)2.12787819
84Cerebral hypomyelination (HP:0006808)2.11752793
85Hepatocellular necrosis (HP:0001404)2.10269691
86Medial flaring of the eyebrow (HP:0010747)2.09136848
87Hemiparesis (HP:0001269)2.07262212
88Agitation (HP:0000713)2.06815520
89Hyperglycemia (HP:0003074)2.06680517
90Prolonged QT interval (HP:0001657)2.04847068
91Resting tremor (HP:0002322)2.04653682
92Nephrogenic diabetes insipidus (HP:0009806)2.03835975
93Atrial fibrillation (HP:0005110)2.02099314
94Abnormal EKG (HP:0003115)2.00808489
95Central scotoma (HP:0000603)2.00638228
96Oligomenorrhea (HP:0000876)2.00375023
97Morphological abnormality of the pyramidal tract (HP:0002062)1.99571282
98Urinary urgency (HP:0000012)1.98597866
99Primary atrial arrhythmia (HP:0001692)1.97843142
100Generalized myoclonic seizures (HP:0002123)1.96592811
101Large for gestational age (HP:0001520)1.96325954
102Optic disc pallor (HP:0000543)1.94986370
103Incomplete penetrance (HP:0003829)1.94672635
104Sleep apnea (HP:0010535)1.93322072
105Hemiplegia (HP:0002301)1.93193034
106Horizontal nystagmus (HP:0000666)1.92542137
107Spastic gait (HP:0002064)1.91034606
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90903620
109Abnormality of alanine metabolism (HP:0010916)1.90903620
110Hyperalaninemia (HP:0003348)1.90903620
111Diminished movement (HP:0002374)1.89195562
112Torticollis (HP:0000473)1.87666198
113Supraventricular tachycardia (HP:0004755)1.87646965
114Craniofacial dystonia (HP:0012179)1.87508968
115Left ventricular hypertrophy (HP:0001712)1.87414190
116Neoplasm of the peripheral nervous system (HP:0100007)1.86214612
117Spastic tetraplegia (HP:0002510)1.86182677
118Blue irides (HP:0000635)1.85380503
119Abnormality of saccadic eye movements (HP:0000570)1.84804167
120Insulin-resistant diabetes mellitus (HP:0000831)1.84515378
121Focal dystonia (HP:0004373)1.84479535
122Calf muscle hypertrophy (HP:0008981)1.83447494
123Muscle hypertrophy of the lower extremities (HP:0008968)1.82810340
124Gait ataxia (HP:0002066)1.81594365
125Mutism (HP:0002300)1.81461588
126Termporal pattern (HP:0011008)1.81339098
127Delusions (HP:0000746)1.77968495
128Type II lissencephaly (HP:0007260)1.75398601
129Ketosis (HP:0001946)1.74502382
130Methylmalonic acidemia (HP:0002912)1.68840006
131Choreoathetosis (HP:0001266)1.67441708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.22047527
2CASK3.93364494
3MAP3K43.70012340
4MAP2K73.55761408
5EPHA43.50651782
6FRK3.49904690
7MAP3K123.26027754
8MAP3K92.70454397
9CDK192.44495921
10MINK12.34366153
11DAPK22.32178570
12MAP2K42.16977666
13RIPK42.08506145
14PLK21.99008992
15BMPR1B1.95160970
16DAPK11.90765787
17PRPF4B1.86250354
18CSNK1G21.80526647
19PAK61.68765790
20AKT31.64740952
21CSNK1G31.63505621
22MARK11.61518458
23CSNK1G11.59171819
24GRK51.53065776
25FGFR21.52905736
26NME11.38990803
27OXSR11.32334901
28CCNB11.30297768
29CDK51.29799614
30PDK41.29145525
31PDK31.29145525
32NTRK21.28629705
33PRKCG1.28168542
34CAMKK21.25370687
35SIK31.23666974
36BMPR21.23253669
37ARAF1.20982659
38CAMKK11.18424323
39CAMK2A1.16812677
40SGK21.16544777
41STK381.16512416
42FES1.16232409
43PNCK1.14916148
44TNIK1.14800156
45PINK11.14479707
46MAP3K21.13762268
47CSNK1A1L1.12940027
48MAPK131.10279052
49LMTK21.09775583
50SGK2231.08755049
51SGK4941.08755049
52KSR21.06285949
53GRK71.05537437
54NTRK11.03167539
55PHKG11.02868563
56PHKG21.02868563
57NEK11.00029406
58SIK20.99814703
59TSSK60.99240898
60KSR10.97580000
61MAP3K130.92228514
62MAP3K110.91775557
63PRKD30.90892170
64CAMK2B0.90726074
65TRIM280.90308347
66WNK30.88141590
67MAP4K20.85447362
68CAMK10.84171678
69SGK30.82680277
70MYLK0.81138829
71WNK10.79193952
72PTK2B0.76997938
73CAMK2D0.76967675
74CDK180.76364173
75TNK20.75674142
76ALK0.74983143
77PRKCE0.74376737
78PRKCH0.73808203
79STK110.73129034
80PRKCZ0.70774607
81CDK150.70443042
82CDK140.68780498
83PDK20.68044851
84PDK10.67694384
85UHMK10.66498085
86BRAF0.66421273
87SGK10.64432395
88LIMK10.61187185
89ACVR1B0.60344398
90CDK11A0.59153582
91CAMK2G0.57944146
92ERBB30.57782238
93DYRK1A0.57532393
94PDPK10.57089831
95CSNK1D0.55663836
96MUSK0.55031137
97GRK10.54753373
98CSNK1A10.53914315
99CDC42BPA0.53913598
100DAPK30.50941704
101PAK30.49900526
102PRKG10.49795415
103STK240.49255154
104NEK60.49183525
105TESK10.47903795
106CSNK1E0.45394241
107STK390.45202933
108CAMK40.44773926
109MAP3K10.44180742
110FER0.43983069
111MAPKAPK50.42700269
112PRKACA0.42489587
113CDK30.40977165
114RPS6KA30.39958446
115WNK40.39395803
116PKN10.38453044
117MAP2K60.38203255
118RET0.37118284
119ADRBK10.37049468
120PRKCB0.36748311
121RAF10.36670791
122INSRR0.36063633
123ROCK20.35928506
124MAPK70.35827118
125BCR0.35214034
126PRKG20.34894981
127LATS20.34085840
128ADRBK20.34026778
129MAP2K10.33740123
130DYRK20.33607944
131PRKCA0.32196977
132MAPK120.31934803

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.15281831
2Synaptic vesicle cycle_Homo sapiens_hsa047214.01019686
3Collecting duct acid secretion_Homo sapiens_hsa049662.87516547
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82638009
5GABAergic synapse_Homo sapiens_hsa047272.70403261
6Circadian entrainment_Homo sapiens_hsa047132.60265254
7Morphine addiction_Homo sapiens_hsa050322.59958315
8Olfactory transduction_Homo sapiens_hsa047402.53259377
9Amphetamine addiction_Homo sapiens_hsa050312.45104104
10Long-term potentiation_Homo sapiens_hsa047202.45025478
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.36763341
12Glutamatergic synapse_Homo sapiens_hsa047242.35099083
13Dopaminergic synapse_Homo sapiens_hsa047282.11918736
14Insulin secretion_Homo sapiens_hsa049112.08517327
15Oxidative phosphorylation_Homo sapiens_hsa001902.01280935
16Taste transduction_Homo sapiens_hsa047422.00742671
17Salivary secretion_Homo sapiens_hsa049702.00126946
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80819746
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77245111
20Vibrio cholerae infection_Homo sapiens_hsa051101.73421686
21Cardiac muscle contraction_Homo sapiens_hsa042601.70648179
22Serotonergic synapse_Homo sapiens_hsa047261.69707661
23Cholinergic synapse_Homo sapiens_hsa047251.68320758
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68256079
25Calcium signaling pathway_Homo sapiens_hsa040201.67967388
26Renin secretion_Homo sapiens_hsa049241.62611994
27Gastric acid secretion_Homo sapiens_hsa049711.61072387
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55323522
29Vitamin B6 metabolism_Homo sapiens_hsa007501.55093059
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55012809
31Long-term depression_Homo sapiens_hsa047301.54868003
32Butanoate metabolism_Homo sapiens_hsa006501.52975685
33Parkinsons disease_Homo sapiens_hsa050121.51822029
34Oxytocin signaling pathway_Homo sapiens_hsa049211.48900459
35Cocaine addiction_Homo sapiens_hsa050301.47989778
36Alzheimers disease_Homo sapiens_hsa050101.39454455
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34359383
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30544798
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.27974528
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23142699
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15945870
42cAMP signaling pathway_Homo sapiens_hsa040241.15494327
43Protein export_Homo sapiens_hsa030601.13929613
44GnRH signaling pathway_Homo sapiens_hsa049121.10381947
45Nitrogen metabolism_Homo sapiens_hsa009101.10370184
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09753694
47Type II diabetes mellitus_Homo sapiens_hsa049301.04719632
48Gap junction_Homo sapiens_hsa045401.03816176
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02078042
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00475711
51Huntingtons disease_Homo sapiens_hsa050160.96999062
52Dilated cardiomyopathy_Homo sapiens_hsa054140.96460333
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92806398
54Phototransduction_Homo sapiens_hsa047440.88457272
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87782516
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.87383578
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82253572
58Estrogen signaling pathway_Homo sapiens_hsa049150.81566233
59Rheumatoid arthritis_Homo sapiens_hsa053230.80743724
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.76081193
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75606693
62ErbB signaling pathway_Homo sapiens_hsa040120.73850549
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73387532
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72717152
65Pancreatic secretion_Homo sapiens_hsa049720.72055872
66Bile secretion_Homo sapiens_hsa049760.68896744
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66623079
68Type I diabetes mellitus_Homo sapiens_hsa049400.66265072
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66076758
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65377879
71Glioma_Homo sapiens_hsa052140.65319077
72Melanogenesis_Homo sapiens_hsa049160.65185439
73Arginine biosynthesis_Homo sapiens_hsa002200.64275706
74Folate biosynthesis_Homo sapiens_hsa007900.63993354
75Glucagon signaling pathway_Homo sapiens_hsa049220.63557530
76MAPK signaling pathway_Homo sapiens_hsa040100.63107004
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61477073
78Peroxisome_Homo sapiens_hsa041460.60206239
79Mineral absorption_Homo sapiens_hsa049780.59537262
80Inositol phosphate metabolism_Homo sapiens_hsa005620.59386162
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58454684
82Fatty acid elongation_Homo sapiens_hsa000620.58274121
83Circadian rhythm_Homo sapiens_hsa047100.57241930
84Thyroid hormone synthesis_Homo sapiens_hsa049180.56803280
85Axon guidance_Homo sapiens_hsa043600.56019470
86Oocyte meiosis_Homo sapiens_hsa041140.55250780
87Propanoate metabolism_Homo sapiens_hsa006400.54609578
88Tryptophan metabolism_Homo sapiens_hsa003800.54397215
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54039590
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53477663
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52298541
92Pyruvate metabolism_Homo sapiens_hsa006200.51241103
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49967283
94Sphingolipid metabolism_Homo sapiens_hsa006000.49782473
95beta-Alanine metabolism_Homo sapiens_hsa004100.49475534
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49009627
97Sulfur metabolism_Homo sapiens_hsa009200.48458494
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46424798
99Phagosome_Homo sapiens_hsa041450.43708931
100Ras signaling pathway_Homo sapiens_hsa040140.43429727
101Phenylalanine metabolism_Homo sapiens_hsa003600.42543176
102Dorso-ventral axis formation_Homo sapiens_hsa043200.42542348
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42490769
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42236724
105Arginine and proline metabolism_Homo sapiens_hsa003300.41604534
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.41154698
107African trypanosomiasis_Homo sapiens_hsa051430.38994252
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37714365
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36726140
110Fatty acid metabolism_Homo sapiens_hsa012120.34492969
111Choline metabolism in cancer_Homo sapiens_hsa052310.33333101
112Fatty acid biosynthesis_Homo sapiens_hsa000610.32960967
113Alcoholism_Homo sapiens_hsa050340.32014383
114Histidine metabolism_Homo sapiens_hsa003400.31585288
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31418301
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.29806652
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29475273
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29125929
119Rap1 signaling pathway_Homo sapiens_hsa040150.29058720
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28876702
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.25973166
122Insulin signaling pathway_Homo sapiens_hsa049100.25668909
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24408170
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22079610
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21809315
126Endocytosis_Homo sapiens_hsa041440.20800572
127Regulation of autophagy_Homo sapiens_hsa041400.20366966
128Melanoma_Homo sapiens_hsa052180.19819616
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17749472
130Chemokine signaling pathway_Homo sapiens_hsa040620.17424926
131Ovarian steroidogenesis_Homo sapiens_hsa049130.16422327
132Wnt signaling pathway_Homo sapiens_hsa043100.16028502
133VEGF signaling pathway_Homo sapiens_hsa043700.15741333

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