KRT23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)8.29556786
2desmosome organization (GO:0002934)8.13771519
3positive regulation of cellular amide metabolic process (GO:0034250)8.00916763
4regulation of water loss via skin (GO:0033561)7.64052209
5keratinization (GO:0031424)6.42546100
6molting cycle (GO:0042303)5.81970691
7hair cycle (GO:0042633)5.81970691
8bundle of His cell to Purkinje myocyte communication (GO:0086069)5.70036852
9positive regulation of interleukin-8 secretion (GO:2000484)5.67256610
10xenobiotic catabolic process (GO:0042178)5.54035145
11multicellular organismal water homeostasis (GO:0050891)5.40260213
12response to nitrosative stress (GO:0051409)5.39296861
13hemidesmosome assembly (GO:0031581)5.28286496
14cellular glucuronidation (GO:0052695)5.14828030
15hormone catabolic process (GO:0042447)4.98302836
16uronic acid metabolic process (GO:0006063)4.91830149
17glucuronate metabolic process (GO:0019585)4.91830149
18positive regulation of humoral immune response (GO:0002922)4.74701537
19water homeostasis (GO:0030104)4.70453780
20phospholipid efflux (GO:0033700)4.64873758
21regulation of cellular amide metabolic process (GO:0034248)4.63180057
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.25939058
23linoleic acid metabolic process (GO:0043651)4.23827976
24defense response to Gram-negative bacterium (GO:0050829)4.21874693
25keratinocyte differentiation (GO:0030216)4.14945135
26glutathione derivative metabolic process (GO:1901685)4.10961991
27glutathione derivative biosynthetic process (GO:1901687)4.10961991
28dendritic cell migration (GO:0036336)4.08949100
29surfactant homeostasis (GO:0043129)4.00823420
30regulation of interleukin-8 secretion (GO:2000482)3.99742519
31detection of bacterium (GO:0016045)3.98647520
32sulfur amino acid catabolic process (GO:0000098)3.94819337
33high-density lipoprotein particle remodeling (GO:0034375)3.92733232
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.86748644
35chemical homeostasis within a tissue (GO:0048875)3.85437378
36detection of external biotic stimulus (GO:0098581)3.84405136
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.80666499
38L-phenylalanine catabolic process (GO:0006559)3.80666499
39peptide cross-linking (GO:0018149)3.78272783
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.73824810
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.73824810
42modulation by symbiont of host immune response (GO:0052553)3.73824810
43positive regulation by symbiont of host defense response (GO:0052509)3.73824810
44modulation by symbiont of host defense response (GO:0052031)3.73824810
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.73824810
46intestinal cholesterol absorption (GO:0030299)3.70274492
47peptide catabolic process (GO:0043171)3.60248592
48positive regulation of transforming growth factor beta production (GO:0071636)3.59924895
49L-phenylalanine metabolic process (GO:0006558)3.57930176
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.57930176
51negative regulation of lipase activity (GO:0060192)3.56514048
52regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.53781707
53positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.53781707
54reverse cholesterol transport (GO:0043691)3.53751884
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.52425876
56regulation of cholesterol esterification (GO:0010872)3.49628791
57benzene-containing compound metabolic process (GO:0042537)3.47990900
58fatty acid elongation (GO:0030497)3.46231180
59detection of other organism (GO:0098543)3.46134486
60protein-lipid complex remodeling (GO:0034368)3.42942147
61macromolecular complex remodeling (GO:0034367)3.42942147
62plasma lipoprotein particle remodeling (GO:0034369)3.42942147
63regulation of phospholipase A2 activity (GO:0032429)3.42777826
64regulation of cholesterol homeostasis (GO:2000188)3.41480842
65defense response to fungus (GO:0050832)3.38765176
66detection of molecule of bacterial origin (GO:0032490)3.36781813
67epidermal cell differentiation (GO:0009913)3.35568361
68intermediate filament organization (GO:0045109)3.34858337
69macrophage activation involved in immune response (GO:0002281)3.34016349
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.33899385
71negative regulation of cell killing (GO:0031342)3.33899385
72epidermis development (GO:0008544)3.33855600
73neutrophil activation involved in immune response (GO:0002283)3.32527401
74regulation of transforming growth factor beta1 production (GO:0032908)3.26049045
75detection of biotic stimulus (GO:0009595)3.24402402
76cysteine metabolic process (GO:0006534)3.23539512
77aromatic amino acid family catabolic process (GO:0009074)3.23480527
78regulation of cell proliferation involved in kidney development (GO:1901722)3.23381990
79positive regulation of T-helper 1 type immune response (GO:0002827)3.22536123
80alpha-linolenic acid metabolic process (GO:0036109)3.21884985
81positive regulation of p38MAPK cascade (GO:1900745)3.21143830
82negative regulation of interleukin-17 production (GO:0032700)3.20351216
83response to peptidoglycan (GO:0032494)3.18442592
84antigen processing and presentation of endogenous antigen (GO:0019883)3.18159305
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.15695887
86low-density lipoprotein particle remodeling (GO:0034374)3.14704356
87one-carbon compound transport (GO:0019755)3.12290253
88hypotonic response (GO:0006971)3.11975677
89glutathione metabolic process (GO:0006749)3.10491876
90bile acid biosynthetic process (GO:0006699)3.09185382
91regulation of cholesterol biosynthetic process (GO:0045540)3.08729159
92bile acid metabolic process (GO:0008206)3.08398546
93bile acid and bile salt transport (GO:0015721)3.08295467
94very long-chain fatty acid metabolic process (GO:0000038)3.05568231
95natural killer cell activation involved in immune response (GO:0002323)3.04146810
96amino-acid betaine metabolic process (GO:0006577)3.02642459
97negative regulation of sterol transport (GO:0032372)3.02570195
98negative regulation of cholesterol transport (GO:0032375)3.02570195
99flavonoid metabolic process (GO:0009812)3.01938528
100cholesterol efflux (GO:0033344)3.00083972
101glyoxylate metabolic process (GO:0046487)2.96954055
102L-ascorbic acid metabolic process (GO:0019852)2.95942489
103atrioventricular valve morphogenesis (GO:0003181)2.95849160
104skin morphogenesis (GO:0043589)2.92897630
105protein carboxylation (GO:0018214)2.92099036
106peptidyl-glutamic acid carboxylation (GO:0017187)2.92099036
107regulation of MHC class I biosynthetic process (GO:0045343)2.89991899
108regulation of triglyceride catabolic process (GO:0010896)2.89530278
109positive regulation of glomerulus development (GO:0090193)2.85775830
110kynurenine metabolic process (GO:0070189)2.84192889
111keratinocyte proliferation (GO:0043616)2.84125888
112ectoderm development (GO:0007398)2.83702922
113tryptophan catabolic process (GO:0006569)2.83677704
114indole-containing compound catabolic process (GO:0042436)2.83677704
115indolalkylamine catabolic process (GO:0046218)2.83677704
116fibrinolysis (GO:0042730)2.83227560
117positive regulation of keratinocyte differentiation (GO:0045618)2.83056124
118renal absorption (GO:0070293)2.82733409
119positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.82626247
120triglyceride homeostasis (GO:0070328)2.82380549
121acylglycerol homeostasis (GO:0055090)2.82380549
122lipoxygenase pathway (GO:0019372)2.80902538
123regulation of transforming growth factor beta production (GO:0071634)2.80533141
124neutrophil activation (GO:0042119)2.79681302
125positive regulation of sterol transport (GO:0032373)2.79423550
126positive regulation of cholesterol transport (GO:0032376)2.79423550
127purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.78791147
1283-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.78791147
129urea metabolic process (GO:0019627)2.78144759
130urea cycle (GO:0000050)2.78144759
131regulation of bile acid biosynthetic process (GO:0070857)2.77742584
132positive regulation of epidermis development (GO:0045684)2.77265930
133response to fungus (GO:0009620)2.76847837
134regulation of interferon-beta biosynthetic process (GO:0045357)2.76139377
135iron ion import (GO:0097286)2.72372795
136negative regulation of fibrinolysis (GO:0051918)2.72313029
137positive regulation of cholesterol efflux (GO:0010875)2.71564702
138primary alcohol catabolic process (GO:0034310)2.71144211
139positive regulation of gamma-delta T cell activation (GO:0046645)2.69526764
140leukocyte migration involved in inflammatory response (GO:0002523)2.68971367
141keratinocyte development (GO:0003334)2.68543225
142ethanol metabolic process (GO:0006067)2.67498190
143regulation of fibrinolysis (GO:0051917)2.67359740
144pyrimidine-containing compound transmembrane transport (GO:0072531)2.67165975
145diterpenoid biosynthetic process (GO:0016102)2.66181327
146tryptophan metabolic process (GO:0006568)2.66148202
147macrophage activation (GO:0042116)2.64638236
148antimicrobial humoral response (GO:0019730)2.64466280
149positive regulation of interleukin-6 production (GO:0032755)2.64337855
150intestinal epithelial cell development (GO:0060576)2.62924040
151regulation of cholesterol metabolic process (GO:0090181)2.62444969
152regulation of T-helper 1 type immune response (GO:0002825)2.61821848
153granulocyte activation (GO:0036230)2.58679190
154regulation of interleukin-6 production (GO:0032675)2.58389600
155negative regulation of lymphocyte mediated immunity (GO:0002707)2.57661996
156regulation of ruffle assembly (GO:1900027)2.57544739
157activation of MAPKKK activity (GO:0000185)2.56220855
158positive regulation of Cdc42 GTPase activity (GO:0043089)2.55365423
159regulation of mast cell degranulation (GO:0043304)2.54205890
160response to host (GO:0075136)2.51866895
161response to host defenses (GO:0052200)2.51866895
162response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.51866895
163microglial cell activation (GO:0001774)2.51465303
164regulation of myeloid leukocyte mediated immunity (GO:0002886)2.50006009
165neutrophil mediated immunity (GO:0002446)2.47941228
166production of molecular mediator involved in inflammatory response (GO:0002532)2.46065815
167mammary gland epithelial cell proliferation (GO:0033598)2.45821228
168positive regulation of epidermal cell differentiation (GO:0045606)2.45754331
169regulation of leukocyte degranulation (GO:0043300)2.45415356
170positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.44988898
171leukocyte aggregation (GO:0070486)2.43743798
172positive regulation of response to biotic stimulus (GO:0002833)2.43654022
173regulation of hair cycle (GO:0042634)2.41503264
174branching involved in labyrinthine layer morphogenesis (GO:0060670)2.40687776
175response to host immune response (GO:0052572)2.39958496
176response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.39958496
177negative regulation of toll-like receptor signaling pathway (GO:0034122)2.39009777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.08709060
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.06898615
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.05486103
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.76807752
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.50798170
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.18319859
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.16675267
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.95878032
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.73196565
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.70451817
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.59463747
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.46404011
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.42714063
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.33512967
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.24845577
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20522132
17P63_26484246_Chip-Seq_KERATINOCYTES_Human2.17901064
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11852433
19* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.07979937
20ZNF263_19887448_ChIP-Seq_K562_Human2.03649052
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01592111
22SOX9_24532713_ChIP-Seq_HFSC_Mouse1.99375275
23GATA4_25053715_ChIP-Seq_YYC3_Human1.90330435
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.86160830
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80865009
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78040164
27SOX2_20726797_ChIP-Seq_SW620_Human1.77606401
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74876407
29CLOCK_20551151_ChIP-Seq_293T_Human1.73062014
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.71817766
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71486021
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71486021
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66086368
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63724088
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.61821762
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60622951
37* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60501330
38TCF7_22412390_ChIP-Seq_EML_Mouse1.60380950
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56503482
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56462938
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55423205
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54403085
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51577315
44* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51533008
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.47983980
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.47229363
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.43202060
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42058086
49VDR_24763502_ChIP-Seq_THP-1_Human1.41286907
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39835204
51GATA6_25053715_ChIP-Seq_YYC3_Human1.38412711
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34943073
53GATA3_24758297_ChIP-Seq_MCF-7_Human1.34413396
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34273845
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34010775
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.32808466
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31908633
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.27808106
59* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25269593
60VDR_21846776_ChIP-Seq_THP-1_Human1.24405622
61BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.23604248
62TP63_23658742_ChIP-Seq_EP156T_Human1.21145879
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.20354585
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19065313
65RACK7_27058665_Chip-Seq_MCF-7_Human1.18338433
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18259936
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18106035
68KLF5_25053715_ChIP-Seq_YYC3_Human1.17250151
69TP53_18474530_ChIP-ChIP_U2OS_Human1.16740024
70CJUN_26792858_Chip-Seq_BT549_Human1.16655970
71AHR_22903824_ChIP-Seq_MCF-7_Human1.16172109
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15266768
73RUNX_20019798_ChIP-Seq_JUKART_Human1.15126213
74MAF_26560356_Chip-Seq_TH1_Human1.14549517
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14361319
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13827941
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12175462
78SPI1_23127762_ChIP-Seq_K562_Human1.12131737
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11776295
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11262425
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.10981101
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09396187
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.09374190
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07874354
85KDM2B_26808549_Chip-Seq_DND41_Human1.06776662
86SCL_19346495_ChIP-Seq_HPC-7_Human1.06413100
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06022997
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05292331
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04412478
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04057523
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03308575
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02440885
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01832513
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01367120
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00840061
96KDM2B_26808549_Chip-Seq_K562_Human1.00357840
97* ESR1_20079471_ChIP-ChIP_T-47D_Human0.99822272
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97358626
99FOXA2_19822575_ChIP-Seq_HepG2_Human0.96525602
100TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95272899
101UTX_26944678_Chip-Seq_JUKART_Human0.94702451
102* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93351257
103VDR_24787735_ChIP-Seq_THP-1_Human0.93200735
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92842853
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92842853
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91940598
107ATF3_27146783_Chip-Seq_COLON_Human0.91922078
108RXR_22108803_ChIP-Seq_LS180_Human0.91761358
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90647668
110P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90559898
111STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90527130
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.89132596
113GATA2_21666600_ChIP-Seq_HMVEC_Human0.88911203
114SPI1_23547873_ChIP-Seq_NB4_Human0.88747991
115BCAT_22108803_ChIP-Seq_LS180_Human0.87620564
116CEBPB_22108803_ChIP-Seq_LS180_Human0.83705356
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.83145981
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79754591
119TP63_22573176_ChIP-Seq_HFKS_Human0.79243935
120FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79229370
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78909661
122JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78416067
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78038161
124UBF1/2_26484160_Chip-Seq_HMECs_Human0.77023847
125* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76167524
126LXR_22292898_ChIP-Seq_THP-1_Human0.75955912
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72666326
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.72294297
129EGR1_19032775_ChIP-ChIP_M12_Human0.70300577
130GATA1_22025678_ChIP-Seq_K562_Human0.69410746
131GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.69028193
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.68343230
133DNAJC2_21179169_ChIP-ChIP_NT2_Human0.67907944
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.65795710
135KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.65795710
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.65795710
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.65530906
138TP53_20018659_ChIP-ChIP_R1E_Mouse0.65374036
139TBX20_22328084_ChIP-Seq_HEART_Mouse0.63271721
140TBX20_22080862_ChIP-Seq_HEART_Mouse0.63271721
141CTCF_27219007_Chip-Seq_Bcells_Human0.63037751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.86561937
2MP0010234_abnormal_vibrissa_follicle5.01729368
3MP0005275_abnormal_skin_tensile3.89501732
4MP0002139_abnormal_hepatobiliary_system3.82033506
5MP0008875_abnormal_xenobiotic_pharmacok3.46608078
6MP0005501_abnormal_skin_physiology3.35240282
7MP0002254_reproductive_system_inflammat3.29950084
8MP0005085_abnormal_gallbladder_physiolo3.16147034
9MP0003941_abnormal_skin_development3.15237839
10MP0005451_abnormal_body_composition3.14770054
11MP0005365_abnormal_bile_salt2.82993183
12MP0002098_abnormal_vibrissa_morphology2.81872645
13MP0005360_urolithiasis2.73799474
14MP0003724_increased_susceptibility_to2.64833736
15MP0000579_abnormal_nail_morphology2.62735391
16MP0002060_abnormal_skin_morphology2.53536378
17MP0001216_abnormal_epidermal_layer2.43642514
18MP0010678_abnormal_skin_adnexa2.25410180
19MP0003436_decreased_susceptibility_to2.24522163
20MP0003191_abnormal_cellular_cholesterol2.21556024
21MP0004947_skin_inflammation2.19794840
22MP0000647_abnormal_sebaceous_gland2.19589606
23MP0001666_abnormal_nutrient_absorption2.13466133
24MP0003705_abnormal_hypodermis_morpholog2.13406189
25MP0004381_abnormal_hair_follicle2.13284606
26MP0008789_abnormal_olfactory_epithelium2.06973250
27MP0005083_abnormal_biliary_tract2.03756038
28MP0010771_integument_phenotype2.01635885
29MP0003453_abnormal_keratinocyte_physiol1.89218750
30MP0001346_abnormal_lacrimal_gland1.88207710
31MP0000383_abnormal_hair_follicle1.84958001
32MP0008260_abnormal_autophagy1.84905149
33MP0000377_abnormal_hair_follicle1.82374993
34MP0000762_abnormal_tongue_morphology1.80014248
35MP0010329_abnormal_lipoprotein_level1.79619341
36MP0000566_synostosis1.77578088
37MP0005394_taste/olfaction_phenotype1.74242096
38MP0005499_abnormal_olfactory_system1.74242096
39MP0003252_abnormal_bile_duct1.68456777
40MP0000467_abnormal_esophagus_morphology1.68405546
41MP0003806_abnormal_nucleotide_metabolis1.66294678
42MP0004782_abnormal_surfactant_physiolog1.66050676
43MP0009840_abnormal_foam_cell1.54796281
44MP0009053_abnormal_anal_canal1.54698790
45MP0002877_abnormal_melanocyte_morpholog1.48906889
46MP0003303_peritoneal_inflammation1.48887800
47MP0000427_abnormal_hair_cycle1.46398569
48MP0002419_abnormal_innate_immunity1.44583296
49MP0009785_altered_susceptibility_to1.44117459
50MP0005025_abnormal_response_to1.43084663
51MP0004264_abnormal_extraembryonic_tissu1.42888690
52MP0004019_abnormal_vitamin_homeostasis1.37567220
53MP0010030_abnormal_orbit_morphology1.35548658
54MP0003828_pulmonary_edema1.32256834
55MP0008004_abnormal_stomach_pH1.32243344
56MP0000858_altered_metastatic_potential1.32056172
57MP0010352_gastrointestinal_tract_polyps1.29410446
58MP0000537_abnormal_urethra_morphology1.26045369
59MP0009931_abnormal_skin_appearance1.25837017
60MP0001191_abnormal_skin_condition1.24873347
61MP0000685_abnormal_immune_system1.24853618
62MP0005076_abnormal_cell_differentiation1.22972035
63MP0003656_abnormal_erythrocyte_physiolo1.22384383
64MP0001800_abnormal_humoral_immune1.21382801
65MP0002138_abnormal_hepatobiliary_system1.20897968
66MP0005000_abnormal_immune_tolerance1.17313969
67MP0010368_abnormal_lymphatic_system1.15567051
68MP0004883_abnormal_blood_vessel1.14367601
69MP0004185_abnormal_adipocyte_glucose1.13773307
70MP0005409_darkened_coat_color1.13467703
71MP0005164_abnormal_response_to1.12835669
72MP0001851_eye_inflammation1.12131528
73MP0002723_abnormal_immune_serum1.10140450
74MP0003878_abnormal_ear_physiology1.07112790
75MP0005377_hearing/vestibular/ear_phenot1.07112790
76MP0002452_abnormal_antigen_presenting1.06858609
77MP0001533_abnormal_skeleton_physiology1.05525360
78MP0004510_myositis1.02944897
79MP0003566_abnormal_cell_adhesion1.00726174
80MP0000367_abnormal_coat/_hair1.00215336
81MP0002420_abnormal_adaptive_immunity1.00094833
82MP0001835_abnormal_antigen_presentation0.99706631
83MP0001819_abnormal_immune_cell0.98962198
84MP0003763_abnormal_thymus_physiology0.97563839
85MP0001243_abnormal_dermal_layer0.96678604
86MP0002118_abnormal_lipid_homeostasis0.95590632
87MP0005023_abnormal_wound_healing0.95358251
88MP0002009_preneoplasia0.92709799
89MP0001790_abnormal_immune_system0.92402365
90MP0005387_immune_system_phenotype0.92402365
91MP0003866_abnormal_defecation0.90108028
92MP0009333_abnormal_splenocyte_physiolog0.88836928
93MP0000678_abnormal_parathyroid_gland0.88760172
94MP0003195_calcinosis0.88696242
95MP0001845_abnormal_inflammatory_respons0.88610003
96MP0005332_abnormal_amino_acid0.88279262
97MP0002405_respiratory_system_inflammati0.88273730
98MP0002148_abnormal_hypersensitivity_rea0.88210594
99MP0002132_abnormal_respiratory_system0.87996823
100MP0003011_delayed_dark_adaptation0.87799184
101MP0001984_abnormal_olfaction0.87388058
102MP0002998_abnormal_bone_remodeling0.87065533
103MP0005248_abnormal_Harderian_gland0.86345015
104MP0003448_altered_tumor_morphology0.86266995
105MP0000609_abnormal_liver_physiology0.81869882
106MP0001873_stomach_inflammation0.80392762
107MP0002233_abnormal_nose_morphology0.78803687
108MP0002166_altered_tumor_susceptibility0.77858793
109MP0003221_abnormal_cardiomyocyte_apopto0.77562897
110MP0000613_abnormal_salivary_gland0.77209157
111MP0002249_abnormal_larynx_morphology0.77007489
112MP0006082_CNS_inflammation0.76316065
113MP0005464_abnormal_platelet_physiology0.72053119
114MP0003186_abnormal_redox_activity0.70823213
115MP0003183_abnormal_peptide_metabolism0.70414504
116MP0003045_fibrosis0.70134755
117MP0002234_abnormal_pharynx_morphology0.68677276
118MP0002090_abnormal_vision0.66617676
119MP0003300_gastrointestinal_ulcer0.65588930
120MP0003091_abnormal_cell_migration0.65560195
121MP0000716_abnormal_immune_system0.65376084
122MP0000465_gastrointestinal_hemorrhage0.64732319
123MP0005408_hypopigmentation0.64575541
124MP0005375_adipose_tissue_phenotype0.63017155
125MP0005166_decreased_susceptibility_to0.62840114
126MP0001340_abnormal_eyelid_morphology0.61805178
127MP0005647_abnormal_sex_gland0.61802134
128MP0000470_abnormal_stomach_morphology0.60694381
129MP0009379_abnormal_foot_pigmentation0.59711296
130MP0002282_abnormal_trachea_morphology0.59605096
131MP0003868_abnormal_feces_composition0.59508895
132MP0002398_abnormal_bone_marrow0.57763598
133MP0002277_abnormal_respiratory_mucosa0.57698661
134MP0009764_decreased_sensitivity_to0.57565874
135MP0004858_abnormal_nervous_system0.57415306
136MP0005220_abnormal_exocrine_pancreas0.53974444
137MP0001849_ear_inflammation0.52991980
138MP0005319_abnormal_enzyme/_coenzyme0.52572726
139MP0009384_cardiac_valve_regurgitation0.51479156
140MP0000627_abnormal_mammary_gland0.51136232
141MP0005666_abnormal_adipose_tissue0.49487279
142MP0000538_abnormal_urinary_bladder0.48429857
143MP0009643_abnormal_urine_homeostasis0.47492544
144MP0002295_abnormal_pulmonary_circulatio0.45367338
145MP0003950_abnormal_plasma_membrane0.44903588
146MP0004272_abnormal_basement_membrane0.42227354
147MP0005084_abnormal_gallbladder_morpholo0.42103530
148MP0003075_altered_response_to0.41924207
149MP0010155_abnormal_intestine_physiology0.40910038
150MP0001177_atelectasis0.39852236
151MP0005367_renal/urinary_system_phenotyp0.39288295
152MP0000516_abnormal_urinary_system0.39288295

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.72036622
2Hypotrichosis (HP:0001006)5.43220886
3Woolly hair (HP:0002224)5.41483870
4Onycholysis (HP:0001806)5.33593450
5Plantar hyperkeratosis (HP:0007556)5.04425697
6Congenital ichthyosiform erythroderma (HP:0007431)4.92392241
7Fragile nails (HP:0001808)4.87593559
8Lip pit (HP:0100267)4.56170754
9Increased IgE level (HP:0003212)4.47536686
10Palmoplantar hyperkeratosis (HP:0000972)4.37817219
11Abnormality of nail color (HP:0100643)4.31139974
12Palmar hyperkeratosis (HP:0010765)4.16153712
13Intrahepatic cholestasis (HP:0001406)4.04645171
14Milia (HP:0001056)3.85826266
15Deep venous thrombosis (HP:0002625)3.79026424
16Alopecia of scalp (HP:0002293)3.77382207
17Nail dystrophy (HP:0008404)3.69334260
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.67306312
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.57830390
20Xanthomatosis (HP:0000991)3.55053537
21Curly hair (HP:0002212)3.47575393
22Erythroderma (HP:0001019)3.37381994
23Erythema (HP:0010783)3.36587940
24Follicular hyperkeratosis (HP:0007502)3.26239207
25Oral leukoplakia (HP:0002745)3.25587968
26Pili torti (HP:0003777)3.19946623
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.15755475
28Orchitis (HP:0100796)3.15353337
29Myositis (HP:0100614)3.09702408
30Thick nail (HP:0001805)3.09332474
31Hypobetalipoproteinemia (HP:0003563)3.00110858
32Recurrent bacterial skin infections (HP:0005406)2.99696008
33Corneal erosion (HP:0200020)2.95951803
34Abnormality of macrophages (HP:0004311)2.95112269
35Abnormal blistering of the skin (HP:0008066)2.91600561
36Distal lower limb muscle weakness (HP:0009053)2.90759211
37Pruritus (HP:0000989)2.87805360
38Retrobulbar optic neuritis (HP:0100654)2.86329755
39Optic neuritis (HP:0100653)2.86329755
40Gangrene (HP:0100758)2.84183753
41Epidermoid cyst (HP:0200040)2.83045712
42Prolonged partial thromboplastin time (HP:0003645)2.80728457
43Ectropion (HP:0000656)2.71389165
44Fat malabsorption (HP:0002630)2.68280238
45Bifid scrotum (HP:0000048)2.67058324
46Hyperlipoproteinemia (HP:0010980)2.66644833
47Recurrent abscess formation (HP:0002722)2.64721820
48Urticaria (HP:0001025)2.64624969
49Atrophic scars (HP:0001075)2.64128695
50Ventricular tachycardia (HP:0004756)2.62599806
51Hypolipoproteinemia (HP:0010981)2.56741539
52Natal tooth (HP:0000695)2.56434115
53Hypoalphalipoproteinemia (HP:0003233)2.54320191
54Recurrent gram-negative bacterial infections (HP:0005420)2.52882204
55Keratoconjunctivitis sicca (HP:0001097)2.52568623
56Advanced eruption of teeth (HP:0006288)2.48416595
57Hyporeflexia of lower limbs (HP:0002600)2.46142682
58Brittle hair (HP:0002299)2.42046337
59Hypergammaglobulinemia (HP:0010702)2.39968728
60Parakeratosis (HP:0001036)2.39156403
61Acanthosis nigricans (HP:0000956)2.37997230
62Humeroradial synostosis (HP:0003041)2.37701289
63Synostosis involving the elbow (HP:0003938)2.37701289
64Sparse eyelashes (HP:0000653)2.36453460
65Palmoplantar keratoderma (HP:0000982)2.36336094
66Dehydration (HP:0001944)2.32011147
67Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.30201746
68Abnormality of the salivary glands (HP:0010286)2.29037872
69Skin ulcer (HP:0200042)2.28603890
70Recurrent skin infections (HP:0001581)2.27269496
71Gingivitis (HP:0000230)2.26436122
72Subacute progressive viral hepatitis (HP:0006572)2.26156187
73Keratoconjunctivitis (HP:0001096)2.24306375
74Gout (HP:0001997)2.24059429
75Hypohidrosis (HP:0000966)2.22673893
76Gastrointestinal infarctions (HP:0005244)2.22562561
77Abnormal hair laboratory examination (HP:0003328)2.21068376
78Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20041637
79Conjunctival hamartoma (HP:0100780)2.20026202
80Steatorrhea (HP:0002570)2.19450236
81Abnormality of the phalanges of the 2nd finger (HP:0009541)2.15242280
82Stenosis of the external auditory canal (HP:0000402)2.14886982
83Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.14321075
84Hypophosphatemic rickets (HP:0004912)2.13192097
85Hyperhidrosis (HP:0000975)2.12182186
86Abnormality of the gastric mucosa (HP:0004295)2.11324194
87Elevated erythrocyte sedimentation rate (HP:0003565)2.10146893
88Vascular calcification (HP:0004934)2.09820391
89Malnutrition (HP:0004395)2.09394528
90Hypercholesterolemia (HP:0003124)2.06736186
91Ridged nail (HP:0001807)2.05307386
92Sparse scalp hair (HP:0002209)2.04057459
93Congenital, generalized hypertrichosis (HP:0004540)2.02426942
94Eczematoid dermatitis (HP:0000976)2.02192413
95Sepsis (HP:0100806)2.01720135
96Abnormality of the axillary hair (HP:0100134)2.01631281
97Abnormality of secondary sexual hair (HP:0009888)2.01631281
98Interstitial pulmonary disease (HP:0006530)2.01096584
99Esophageal varix (HP:0002040)2.00828302
100Arterial tortuosity (HP:0005116)1.98328583
101Hyperglycinuria (HP:0003108)1.97058767
102Villous atrophy (HP:0011473)1.95925338
103Abnormality of small intestinal villus morphology (HP:0011472)1.95925338
104Corneal dystrophy (HP:0001131)1.95251201
105Stomatitis (HP:0010280)1.93861043
106Gingival bleeding (HP:0000225)1.89458375
107Increased serum ferritin (HP:0003281)1.89198335
108Pustule (HP:0200039)1.87959117
109Rickets (HP:0002748)1.87801518
110Mediastinal lymphadenopathy (HP:0100721)1.87773384
111Complement deficiency (HP:0004431)1.87621493
112Cardiovascular calcification (HP:0011915)1.86514130
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84466668
114Abnormality of the middle phalanges of the toes (HP:0010183)1.84013698
115Abnormality of the 2nd finger (HP:0004100)1.82625663
116Hypoglycemic coma (HP:0001325)1.82483262
117Abnormality of purine metabolism (HP:0004352)1.82399632
118Laryngomalacia (HP:0001601)1.81872453
119Abnormal hemoglobin (HP:0011902)1.81507476
120Ketosis (HP:0001946)1.80542851
121Abnormality of the common coagulation pathway (HP:0010990)1.80401370
122Popliteal pterygium (HP:0009756)1.80367224
123Hyperammonemia (HP:0001987)1.80005299
124Abnormal tarsal ossification (HP:0008369)1.79374648
125Joint hemorrhage (HP:0005261)1.78874964
126Alveolar cell carcinoma (HP:0006519)1.77209320
127Lack of skin elasticity (HP:0100679)1.76132241
128Hypoplastic labia majora (HP:0000059)1.76012070
129Conjugated hyperbilirubinemia (HP:0002908)1.74732862
130Recurrent fungal infections (HP:0002841)1.74191631
131Amyloidosis (HP:0011034)1.73947043
132Papilloma (HP:0012740)1.72441135
133Verrucae (HP:0200043)1.72441135
134Blepharitis (HP:0000498)1.71989836
135Glomerulosclerosis (HP:0000096)1.71655440
136Abnormality of sulfur amino acid metabolism (HP:0004339)1.71503100
137Abnormality of glycine metabolism (HP:0010895)1.71079339
138Prolonged bleeding time (HP:0003010)1.70469020
139Hypochromic anemia (HP:0001931)1.68719967
140Hypochromic microcytic anemia (HP:0004840)1.67071350
141Premature loss of primary teeth (HP:0006323)1.66564214
142Abnormality of iron homeostasis (HP:0011031)1.64826769
143Nasal polyposis (HP:0100582)1.62209479
144Oligodontia (HP:0000677)1.61618962
145Peritonitis (HP:0002586)1.61585849
146Vascular tortuosity (HP:0004948)1.60104793
147Cellulitis (HP:0100658)1.59205771
148Menorrhagia (HP:0000132)1.58482736
149Cheilitis (HP:0100825)1.57876479
150Micronodular cirrhosis (HP:0001413)1.57552784
151Chronic obstructive pulmonary disease (HP:0006510)1.55793257
152Obstructive lung disease (HP:0006536)1.55793257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.11864206
2EPHA23.95419922
3MST1R3.74630530
4MAPKAPK33.42141182
5MAP3K33.20292526
6ERN12.97926605
7EPHB22.78911572
8MAP3K22.71628942
9LATS12.69228419
10IRAK42.67184223
11BCKDK2.51373059
12RPS6KB22.47857876
13FRK2.47773225
14FER2.38911903
15SIK11.87215691
16RIPK41.86065851
17MAP2K21.83419257
18CSK1.78036412
19RIPK11.75890133
20CDK61.69307175
21FGFR41.58869814
22MET1.56309102
23IRAK11.48238202
24GRK61.42393275
25STK101.40918065
26ZAP701.39451143
27MAPK151.37197879
28PTK61.37159429
29IRAK21.35039020
30BLK1.34745138
31STK38L1.31870822
32MAP3K61.31746611
33PIK3CG1.31083177
34STK381.29099458
35MAP2K11.27086056
36ERBB41.25031601
37LRRK21.24766823
38TRPM71.22909205
39INSRR1.22606454
40TAOK11.20502799
41MAP2K61.16181543
42FGR1.13539331
43GRK11.13498629
44TESK11.13338017
45HCK1.09227582
46MAP3K71.04920087
47PTK21.04593350
48STK241.04589247
49TAOK31.03012226
50MAP3K121.01723368
51TRIB31.01669813
52MAP4K11.01276371
53SIK31.01169550
54TNK20.99753722
55EPHB10.99159578
56MARK20.98682266
57FGFR10.98038315
58MAP2K30.97945019
59DYRK30.97614466
60LMTK20.96139547
61PAK30.89502435
62BTK0.87994299
63EPHA30.86237529
64TTN0.85673826
65YES10.82750778
66ERBB20.82437291
67ERBB30.81157927
68JAK20.81026543
69HIPK20.80995592
70PRPF4B0.80639663
71IKBKB0.80624573
72DYRK1B0.78658733
73JAK30.78569645
74SGK30.77206586
75MAP3K110.75374036
76FGFR20.74905960
77FES0.74895594
78PRKCI0.74627919
79TYK20.74298126
80CDK120.73810002
81PKN20.71577890
82PIK3CA0.71043242
83TAOK20.69202013
84MAPKAPK20.68397467
85KSR20.67670788
86WNK10.67536922
87MAP3K90.65894339
88PDK20.64916419
89SMG10.64860825
90EEF2K0.64413345
91JAK10.63940939
92NEK90.63613910
93NME10.61885926
94PAK40.61339695
95MAP3K140.59464671
96MAP3K130.59447932
97PRKD20.58999840
98BMPR20.57365594
99AKT30.55427727
100ZAK0.54210076
101MARK30.52329821
102MAP3K10.51836008
103CDC42BPA0.50347576
104ABL20.50063062
105TGFBR20.49835396
106RET0.49637196
107BMPR1B0.48966772
108GSK3A0.48056187
109IRAK30.47210702
110BMX0.47014066
111PRKD10.46769313
112BCR0.46673159
113PDPK10.45777497
114LATS20.44527439
115STK30.44235895
116MTOR0.44102076
117MAP3K50.42514750
118SGK20.41883178
119RPS6KA10.41400456
120SGK2230.40067149
121SGK4940.40067149
122FGFR30.39629840
123MATK0.39171848
124LCK0.38888479
125PRKG20.37929810
126PDK10.36467595
127ROCK10.35345227
128CHUK0.31450019
129NUAK10.30525392
130CSNK1D0.28595012
131EGFR0.28041612
132PRKCE0.27648382
133MAPK40.27561875
134NEK60.26172385
135RPS6KA40.26089349
136MAPKAPK50.25800781
137PDGFRB0.24871510
138ROCK20.24435712
139PRKAA20.24317176
140CSNK1A10.24246503
141NLK0.23849764
142PRKCA0.23795518
143IKBKE0.23531437
144CAMK2G0.23146893
145TBK10.22531627
146MAPK30.21180705
147TGFBR10.20731343
148RPS6KA20.19926659

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.00474663
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.74621486
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.59829081
4Chemical carcinogenesis_Homo sapiens_hsa052043.28275116
5Pentose and glucuronate interconversions_Homo sapiens_hsa000403.05776442
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.94491060
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.48336012
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.41973493
9Sulfur metabolism_Homo sapiens_hsa009202.30888989
10Fat digestion and absorption_Homo sapiens_hsa049752.30618071
11Retinol metabolism_Homo sapiens_hsa008302.25456012
12Histidine metabolism_Homo sapiens_hsa003402.23066303
13Glutathione metabolism_Homo sapiens_hsa004802.01895501
14Osteoclast differentiation_Homo sapiens_hsa043802.01132689
15Fatty acid degradation_Homo sapiens_hsa000711.93768046
16Leishmaniasis_Homo sapiens_hsa051401.91446835
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87366259
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82849730
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.79465014
20Tryptophan metabolism_Homo sapiens_hsa003801.78679823
21Fatty acid elongation_Homo sapiens_hsa000621.77333129
22Nitrogen metabolism_Homo sapiens_hsa009101.75461060
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.75351712
24Acute myeloid leukemia_Homo sapiens_hsa052211.73865811
25Starch and sucrose metabolism_Homo sapiens_hsa005001.68806181
26Caffeine metabolism_Homo sapiens_hsa002321.68297287
27Complement and coagulation cascades_Homo sapiens_hsa046101.64804348
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62559763
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62364778
30beta-Alanine metabolism_Homo sapiens_hsa004101.62302452
31B cell receptor signaling pathway_Homo sapiens_hsa046621.60961349
32PPAR signaling pathway_Homo sapiens_hsa033201.60553776
33Arginine biosynthesis_Homo sapiens_hsa002201.60001934
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.58767643
35Phenylalanine metabolism_Homo sapiens_hsa003601.58113831
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56203060
37ABC transporters_Homo sapiens_hsa020101.53840579
38Peroxisome_Homo sapiens_hsa041461.53685148
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.53507123
40Linoleic acid metabolism_Homo sapiens_hsa005911.51501223
41Tuberculosis_Homo sapiens_hsa051521.50325605
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48857239
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48387085
44Butanoate metabolism_Homo sapiens_hsa006501.47611534
45Toxoplasmosis_Homo sapiens_hsa051451.41044316
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.40642756
47VEGF signaling pathway_Homo sapiens_hsa043701.39590936
48Measles_Homo sapiens_hsa051621.38598323
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37123886
50TNF signaling pathway_Homo sapiens_hsa046681.37044144
51Malaria_Homo sapiens_hsa051441.33597725
52Chronic myeloid leukemia_Homo sapiens_hsa052201.30976870
53Influenza A_Homo sapiens_hsa051641.27776743
54Renal cell carcinoma_Homo sapiens_hsa052111.27341150
55Fatty acid metabolism_Homo sapiens_hsa012121.26856806
56Legionellosis_Homo sapiens_hsa051341.26047515
57Endocytosis_Homo sapiens_hsa041441.23944024
58Bile secretion_Homo sapiens_hsa049761.23862036
59NF-kappa B signaling pathway_Homo sapiens_hsa040641.23727702
60Pancreatic cancer_Homo sapiens_hsa052121.23292065
61T cell receptor signaling pathway_Homo sapiens_hsa046601.23288053
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22643706
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22213060
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18714456
65Propanoate metabolism_Homo sapiens_hsa006401.18370781
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17199780
67Chemokine signaling pathway_Homo sapiens_hsa040621.14527931
68Staphylococcus aureus infection_Homo sapiens_hsa051501.13640504
69Endometrial cancer_Homo sapiens_hsa052131.13469744
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12817325
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12751167
72Non-small cell lung cancer_Homo sapiens_hsa052231.10500762
73Tyrosine metabolism_Homo sapiens_hsa003501.10430113
74Choline metabolism in cancer_Homo sapiens_hsa052311.08448546
75Steroid biosynthesis_Homo sapiens_hsa001001.07516066
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06503280
77FoxO signaling pathway_Homo sapiens_hsa040681.05791687
78Vitamin digestion and absorption_Homo sapiens_hsa049771.03231336
79Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02929392
80Inositol phosphate metabolism_Homo sapiens_hsa005621.02620964
81GnRH signaling pathway_Homo sapiens_hsa049121.02144221
82Apoptosis_Homo sapiens_hsa042101.01988451
83Dorso-ventral axis formation_Homo sapiens_hsa043201.01865152
84ErbB signaling pathway_Homo sapiens_hsa040121.01419662
85Arachidonic acid metabolism_Homo sapiens_hsa005900.98042261
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.97165435
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96934244
88Shigellosis_Homo sapiens_hsa051310.96895837
89Notch signaling pathway_Homo sapiens_hsa043300.96844290
90Platelet activation_Homo sapiens_hsa046110.96104361
91Salmonella infection_Homo sapiens_hsa051320.95571524
92Folate biosynthesis_Homo sapiens_hsa007900.93461293
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.92920857
94Phagosome_Homo sapiens_hsa041450.92288100
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.92159005
96Sulfur relay system_Homo sapiens_hsa041220.92108333
97Glycerolipid metabolism_Homo sapiens_hsa005610.90264334
98Prolactin signaling pathway_Homo sapiens_hsa049170.90220567
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88389376
100Hematopoietic cell lineage_Homo sapiens_hsa046400.86306466
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84551964
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83593385
103Hepatitis B_Homo sapiens_hsa051610.81137009
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80845568
105Herpes simplex infection_Homo sapiens_hsa051680.80377751
106Galactose metabolism_Homo sapiens_hsa000520.79907639
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78038265
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.77960160
109Selenocompound metabolism_Homo sapiens_hsa004500.77081569
110Proteoglycans in cancer_Homo sapiens_hsa052050.75426795
111Tight junction_Homo sapiens_hsa045300.74126515
112Other glycan degradation_Homo sapiens_hsa005110.73990488
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72100042
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71546353
115Graft-versus-host disease_Homo sapiens_hsa053320.71426340
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69065526
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66906841
118MAPK signaling pathway_Homo sapiens_hsa040100.65726450
119Rap1 signaling pathway_Homo sapiens_hsa040150.63214135
120Prostate cancer_Homo sapiens_hsa052150.62440203
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62140670
122Arginine and proline metabolism_Homo sapiens_hsa003300.61792037
123Focal adhesion_Homo sapiens_hsa045100.60808667
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60387367
125Viral myocarditis_Homo sapiens_hsa054160.60303793
126Colorectal cancer_Homo sapiens_hsa052100.59996502
127Mineral absorption_Homo sapiens_hsa049780.59932915
128Ras signaling pathway_Homo sapiens_hsa040140.59470775
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59465972
130mTOR signaling pathway_Homo sapiens_hsa041500.59352887
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59170508
132Insulin signaling pathway_Homo sapiens_hsa049100.58701933
133Ether lipid metabolism_Homo sapiens_hsa005650.58622855
134Estrogen signaling pathway_Homo sapiens_hsa049150.58518283
135Ovarian steroidogenesis_Homo sapiens_hsa049130.57967725
136HIF-1 signaling pathway_Homo sapiens_hsa040660.57257870
137Pancreatic secretion_Homo sapiens_hsa049720.56725976
138Sphingolipid metabolism_Homo sapiens_hsa006000.55882867
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53635837
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51111086
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51030890
142Fatty acid biosynthesis_Homo sapiens_hsa000610.49206162
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45674100
144Thyroid cancer_Homo sapiens_hsa052160.44809587
145Adherens junction_Homo sapiens_hsa045200.44089682
146Pyruvate metabolism_Homo sapiens_hsa006200.43810427
147Bladder cancer_Homo sapiens_hsa052190.40296237
148ECM-receptor interaction_Homo sapiens_hsa045120.38689309
149Protein digestion and absorption_Homo sapiens_hsa049740.38501732
150Cysteine and methionine metabolism_Homo sapiens_hsa002700.36402742
151Hepatitis C_Homo sapiens_hsa051600.35548047
152Carbon metabolism_Homo sapiens_hsa012000.35075004
153Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34513356
154Circadian rhythm_Homo sapiens_hsa047100.30863626
155Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29038523
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.27642434
157Biosynthesis of amino acids_Homo sapiens_hsa012300.26972182
158Small cell lung cancer_Homo sapiens_hsa052220.26401774
159Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25832514
160Leukocyte transendothelial migration_Homo sapiens_hsa046700.25645543
161Insulin resistance_Homo sapiens_hsa049310.25588309
162Hippo signaling pathway_Homo sapiens_hsa043900.22699508
163Lysine degradation_Homo sapiens_hsa003100.22119217
164Amoebiasis_Homo sapiens_hsa051460.20189856
165Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18732795
166TGF-beta signaling pathway_Homo sapiens_hsa043500.17748682
167Metabolic pathways_Homo sapiens_hsa011000.17471106
168Fructose and mannose metabolism_Homo sapiens_hsa000510.17448932
169Pentose phosphate pathway_Homo sapiens_hsa000300.14313469
170Axon guidance_Homo sapiens_hsa043600.13885490
171African trypanosomiasis_Homo sapiens_hsa051430.11876072
172Pertussis_Homo sapiens_hsa051330.11167115
173Gastric acid secretion_Homo sapiens_hsa049710.10687511
174Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10069753
175Adipocytokine signaling pathway_Homo sapiens_hsa049200.08977928

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