KRT24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.81949214
2desmosome organization (GO:0002934)9.32782644
3establishment of skin barrier (GO:0061436)8.04924846
4regulation of water loss via skin (GO:0033561)7.02495703
5pyrimidine dimer repair (GO:0006290)6.72686401
6response to water (GO:0009415)6.45129784
7extracellular fibril organization (GO:0043206)6.43889173
8keratinocyte proliferation (GO:0043616)6.25507791
9multicellular organismal water homeostasis (GO:0050891)5.74775443
10fibril organization (GO:0097435)5.68689304
11negative regulation of keratinocyte proliferation (GO:0010839)5.63011627
12lymph vessel development (GO:0001945)5.59112531
13sequestering of extracellular ligand from receptor (GO:0035581)5.55125044
14outer ear morphogenesis (GO:0042473)5.49184335
15extracellular matrix assembly (GO:0085029)5.48296898
16peptide cross-linking (GO:0018149)5.48216535
17cranial nerve morphogenesis (GO:0021602)5.29011225
18response to UV-B (GO:0010224)4.98904289
19planar cell polarity pathway involved in neural tube closure (GO:0090179)4.83030530
20water homeostasis (GO:0030104)4.78264636
21G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.76498927
22gland morphogenesis (GO:0022612)4.66030520
23limb bud formation (GO:0060174)4.62420365
24positive regulation of protein kinase C signaling (GO:0090037)4.62368740
25monocyte differentiation (GO:0030224)4.59519589
26regulation of secondary heart field cardioblast proliferation (GO:0003266)4.59023434
27regulation of cardioblast proliferation (GO:0003264)4.59023434
28hair cycle (GO:0042633)4.58441352
29molting cycle (GO:0042303)4.58441352
30embryonic viscerocranium morphogenesis (GO:0048703)4.54836866
31cytoskeletal anchoring at plasma membrane (GO:0007016)4.49084560
32ventricular cardiac muscle cell action potential (GO:0086005)4.41692879
33positive regulation of transforming growth factor beta production (GO:0071636)4.40625186
34striated muscle atrophy (GO:0014891)4.40407777
35keratinocyte differentiation (GO:0030216)4.38200791
36epidermis development (GO:0008544)4.37015883
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.32027122
38regulation of transforming growth factor beta1 production (GO:0032908)4.28074043
39O-glycan processing (GO:0016266)4.26750792
40natural killer cell mediated cytotoxicity (GO:0042267)4.13130106
41natural killer cell mediated immunity (GO:0002228)4.13130106
42regulation of female receptivity (GO:0045924)4.12961044
43regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.11968720
44cellular response to vitamin D (GO:0071305)4.04890014
45positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.04745145
46macrophage differentiation (GO:0030225)4.01278231
47bundle of His cell to Purkinje myocyte communication (GO:0086069)3.98793043
48face development (GO:0060324)3.95549853
49regulation of skeletal muscle cell differentiation (GO:2001014)3.91249239
50negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.89697990
51lateral sprouting from an epithelium (GO:0060601)3.84221188
52muscle atrophy (GO:0014889)3.83661803
534-hydroxyproline metabolic process (GO:0019471)3.82694638
54T cell mediated immunity (GO:0002456)3.82481936
55positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.77599693
56activation of JUN kinase activity (GO:0007257)3.77142148
57positive regulation of glomerulus development (GO:0090193)3.75516432
58epidermal cell differentiation (GO:0009913)3.74815509
59peptidyl-proline hydroxylation (GO:0019511)3.74804080
60regulation of transmission of nerve impulse (GO:0051969)3.71699481
61cell proliferation involved in metanephros development (GO:0072203)3.71304147
62negative regulation of cell fate commitment (GO:0010454)3.70732370
63negative regulation of sodium ion transport (GO:0010766)3.66538090
64muscle organ morphogenesis (GO:0048644)3.65844422
65regulation of ruffle assembly (GO:1900027)3.65801011
66cell-substrate junction assembly (GO:0007044)3.64663637
67regulation of heart rate by cardiac conduction (GO:0086091)3.62964607
68myotube differentiation (GO:0014902)3.62819025
69negative regulation of leukocyte chemotaxis (GO:0002689)3.61139771
70regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.60170266
71regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.60170266
72tooth mineralization (GO:0034505)3.59077701
73skeletal muscle adaptation (GO:0043501)3.58817435
74regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.58674652
75negative regulation of oligodendrocyte differentiation (GO:0048715)3.57898521
76prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.55937370
77regulation of ARF GTPase activity (GO:0032312)3.55475445
78negative regulation of osteoblast proliferation (GO:0033689)3.54285344
79thyroid gland development (GO:0030878)3.53009605
80cell communication involved in cardiac conduction (GO:0086065)3.49382680
81pharyngeal system development (GO:0060037)3.48660584
82ribosomal small subunit biogenesis (GO:0042274)3.47507252
83regulation of cell proliferation involved in kidney development (GO:1901722)3.47340022
84female mating behavior (GO:0060180)3.47146128
85membrane tubulation (GO:0097320)3.46989635
86coronary vasculature morphogenesis (GO:0060977)3.45840797
87citrulline biosynthetic process (GO:0019240)3.44925157
88negative regulation of stem cell proliferation (GO:2000647)3.44497321
89lung lobe morphogenesis (GO:0060463)3.44153018
90maternal behavior (GO:0042711)3.42942842
91positive regulation of odontogenesis (GO:0042482)3.42168372
92positive regulation of fatty acid biosynthetic process (GO:0045723)3.41765009
93regulation of heart morphogenesis (GO:2000826)3.40308527
94regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.36859273
95response to histamine (GO:0034776)3.36546749
96cochlea morphogenesis (GO:0090103)3.36068591
97regulation of phospholipase A2 activity (GO:0032429)3.35704178
98aorta morphogenesis (GO:0035909)3.33761494
99regulation of keratinocyte proliferation (GO:0010837)3.33325835
100cell differentiation involved in metanephros development (GO:0072202)3.31939931
101keratinocyte development (GO:0003334)3.31231824
102atrioventricular valve morphogenesis (GO:0003181)3.30226247
103establishment of tissue polarity (GO:0007164)3.28502232
104establishment of planar polarity (GO:0001736)3.28502232
105regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.26782336
106interleukin-1-mediated signaling pathway (GO:0070498)3.25436053
107positive regulation of endothelial cell apoptotic process (GO:2000353)3.25090416
108viral transcription (GO:0019083)3.24993090
109prepulse inhibition (GO:0060134)3.23961951
110arachidonic acid secretion (GO:0050482)3.21395971
111icosanoid secretion (GO:0032309)3.21395971
112hair follicle morphogenesis (GO:0031069)3.19819746
113parental behavior (GO:0060746)3.19478608
114collecting duct development (GO:0072044)3.19217438
115retinoic acid receptor signaling pathway (GO:0048384)3.18327973
116muscle cell fate commitment (GO:0042693)3.17131562
117extracellular regulation of signal transduction (GO:1900115)3.16645086
118extracellular negative regulation of signal transduction (GO:1900116)3.16645086
119adenosine metabolic process (GO:0046085)3.10911332
120response to superoxide (GO:0000303)3.10822683
121aggressive behavior (GO:0002118)3.10262956
122icosanoid transport (GO:0071715)3.09900856
123fatty acid derivative transport (GO:1901571)3.09900856
124neural crest cell development (GO:0014032)3.09590569
125translational termination (GO:0006415)3.08894324
126regulation of apoptotic process involved in morphogenesis (GO:1902337)3.08805727
127endosome organization (GO:0007032)3.08059596
128membrane raft organization (GO:0031579)3.07725032
129regulation of hair follicle development (GO:0051797)3.04781395
130response to oxygen radical (GO:0000305)3.04047269
131intermediate filament organization (GO:0045109)3.03729845
132negative regulation of cell fate specification (GO:0009996)3.03046458
133regulation of mesenchymal cell apoptotic process (GO:2001053)3.02970256
134regulation of hair cycle (GO:0042634)3.02804288
135response to manganese ion (GO:0010042)2.99951096
136cardiac conduction (GO:0061337)2.99495861
137regulation of membrane protein ectodomain proteolysis (GO:0051043)2.99082387
138regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.98094059
139positive regulation of hair cycle (GO:0042635)2.97712449
140positive regulation of hair follicle development (GO:0051798)2.97712449
141embryonic cranial skeleton morphogenesis (GO:0048701)2.97084259
142positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.96514873
143positive regulation of skeletal muscle tissue development (GO:0048643)2.96093003
144pancreas development (GO:0031016)2.94772944
145cardiac muscle cell action potential involved in contraction (GO:0086002)2.94313692
146ectoderm development (GO:0007398)2.92493942
147mesenchymal cell differentiation involved in renal system development (GO:2001012)2.92392568
148mesenchymal cell differentiation involved in kidney development (GO:0072161)2.92392568
149negative regulation of bone remodeling (GO:0046851)2.91595347
150dorsal/ventral axis specification (GO:0009950)2.89824005
151regulation of glucocorticoid metabolic process (GO:0031943)2.89744066
152otic vesicle formation (GO:0030916)2.89560835
153protein hydroxylation (GO:0018126)2.89329298
154regulation of keratinocyte differentiation (GO:0045616)2.89204382
155regulation of macrophage activation (GO:0043030)2.89116937
156outflow tract septum morphogenesis (GO:0003148)2.89055712
157cellular response to vitamin (GO:0071295)2.88938591
158positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)2.88869419
159pattern specification involved in kidney development (GO:0061004)2.88130405
160adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.87054989
161negative regulation of chondrocyte differentiation (GO:0032331)2.86828713
162regulation of hippo signaling (GO:0035330)2.86481812
163hypotonic response (GO:0006971)2.86187665
164apical protein localization (GO:0045176)2.85536951
165lung-associated mesenchyme development (GO:0060484)2.85441140
166regulation of glomerulus development (GO:0090192)2.85421889
167skin morphogenesis (GO:0043589)2.84676423
168regulation of transforming growth factor beta production (GO:0071634)2.84652583
169response to corticosterone (GO:0051412)2.84333408
170cellular response to nicotine (GO:0071316)2.84311609
171negative regulation of protein localization to cell surface (GO:2000009)2.83771084
172cardiac muscle cell action potential (GO:0086001)2.83443304
173alkaloid metabolic process (GO:0009820)2.78498111
174positive regulation of amino acid transport (GO:0051957)2.76448910
175UDP-N-acetylglucosamine metabolic process (GO:0006047)2.75945483
176positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.75297552
177epithelial cell-cell adhesion (GO:0090136)2.74481519
178protein O-linked glycosylation (GO:0006493)2.73985354
179hemidesmosome assembly (GO:0031581)11.7516642
180plasma membrane repair (GO:0001778)11.2102201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* SOX9_24532713_ChIP-Seq_HFSC_Mouse4.25846548
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.94695449
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.22538110
4AR_21572438_ChIP-Seq_LNCaP_Human2.85926304
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.57867099
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28904215
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14048706
8P63_26484246_Chip-Seq_KERATINOCYTES_Human2.12523445
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07278797
10TP63_17297297_ChIP-ChIP_HaCaT_Human10.8092971
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93819449
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92355900
13EED_16625203_ChIP-ChIP_MESCs_Mouse1.90353133
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88050702
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86256406
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86256406
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77980425
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.77909033
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77412185
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74703193
21ZNF263_19887448_ChIP-Seq_K562_Human1.71559556
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71401708
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.65493223
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.64890233
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62656873
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61885932
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61365750
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.60277639
29KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.59014557
30IGF1R_20145208_ChIP-Seq_DFB_Human1.58496360
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.58415582
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.58415582
33TP53_16413492_ChIP-PET_HCT116_Human1.58403211
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.58161242
35FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.57192024
36* GATA3_24758297_ChIP-Seq_MCF-7_Human1.54893072
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48161216
38AHR_22903824_ChIP-Seq_MCF-7_Human1.45788475
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44643669
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43398541
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.43141765
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.42769736
43JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42704265
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38264399
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37215224
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36014893
47* CJUN_26792858_Chip-Seq_BT549_Human1.35515764
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35367676
49DROSHA_22980978_ChIP-Seq_HELA_Human1.35209993
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34479010
51FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33187917
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.30688384
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30384117
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29440992
55JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27594043
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.26643370
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26405833
58TAF15_26573619_Chip-Seq_HEK293_Human1.24437782
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23786841
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22576767
61TP53_18474530_ChIP-ChIP_U2OS_Human1.20131372
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.20042287
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.19945672
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19404842
65EGR1_19032775_ChIP-ChIP_M12_Human1.18856900
66TP63_23658742_ChIP-Seq_EP156T_Human1.18492004
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.15947582
68BRD4_25478319_ChIP-Seq_HGPS_Human1.15059935
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.13977868
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13754440
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.13290576
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12415116
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11446210
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09937696
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.09317637
76* GATA4_25053715_ChIP-Seq_YYC3_Human1.09016963
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07340618
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07071576
79RXR_22108803_ChIP-Seq_LS180_Human1.06331629
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05950548
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05058211
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03938029
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03931287
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03931287
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03652495
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01777137
87SCL_19346495_ChIP-Seq_HPC-7_Human1.01000522
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00803720
89* GATA6_25053715_ChIP-Seq_YYC3_Human1.00358095
90CTCF_27219007_Chip-Seq_Bcells_Human1.00311749
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.00278542
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99608564
93BCAT_22108803_ChIP-Seq_LS180_Human0.99468454
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99179183
95TRIM28_21343339_ChIP-Seq_HEK293_Human0.96933426
96KLF5_25053715_ChIP-Seq_YYC3_Human0.94869588
97GATA2_19941826_ChIP-Seq_K562_Human0.94652526
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94015769
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93636732
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92965670
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92640652
102ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92314930
103TP63_22573176_ChIP-Seq_HFKS_Human0.92302851
104HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91411830
105EP300_21415370_ChIP-Seq_HL-1_Mouse0.91148587
106GATA1_19941826_ChIP-Seq_K562_Human0.90769618
107ATF3_27146783_Chip-Seq_COLON_Human0.90701961
108SOX2_20726797_ChIP-Seq_SW620_Human0.89534622
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89502238
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89374686
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88423361
112CDX2_20551321_ChIP-Seq_CACO-2_Human0.87877375
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.87110754
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86350804
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85819680
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84121215
117FOXA2_19822575_ChIP-Seq_HepG2_Human0.84025521
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83939637
119HTT_18923047_ChIP-ChIP_STHdh_Human0.82634170
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82062010
121RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81253817
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.80045919
123TBX20_22080862_ChIP-Seq_HEART_Mouse0.80045919
124SMAD4_21799915_ChIP-Seq_A2780_Human0.79188324
125P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.78384068
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78341776
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78341776
128KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78341776
129RARG_19884340_ChIP-ChIP_MEFs_Mouse0.76688717
130EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.75896288
131CTBP2_25329375_ChIP-Seq_LNCAP_Human0.75413933
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.75358587
133* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.75209206
134GATA1_22025678_ChIP-Seq_K562_Human0.75202024
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74831303
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74395783
137RNF2_27304074_Chip-Seq_NSC_Mouse0.73953303
138FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73061851
139TCF4_22108803_ChIP-Seq_LS180_Human0.72606463
140GATA6_21074721_ChIP-Seq_CACO-2_Human0.71830543
141KDM2B_26808549_Chip-Seq_K562_Human0.71202498
142ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.70949448
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.69377249
144CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68711395
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.68280800
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.68042528
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67767543
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.67208351
149CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.67018332
150* SMAD3_21741376_ChIP-Seq_EPCs_Human0.66253373
151UBF1/2_26484160_Chip-Seq_HMECs_Human0.66003734
152ISL1_27105846_Chip-Seq_CPCs_Mouse0.65051382
153RUNX1_27514584_Chip-Seq_MCF-7_Human0.64895703
154STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.64631570
155RACK7_27058665_Chip-Seq_MCF-7_Human0.64311568
156PCGF2_27294783_Chip-Seq_NPCs_Mouse0.64193277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.05421744
2MP0002796_impaired_skin_barrier5.27098166
3MP0002254_reproductive_system_inflammat4.63929830
4MP0005451_abnormal_body_composition4.45281714
5MP0000579_abnormal_nail_morphology3.80798834
6MP0001346_abnormal_lacrimal_gland3.53272186
7MP0000762_abnormal_tongue_morphology3.52658551
8MP0003705_abnormal_hypodermis_morpholog3.40996375
9MP0002060_abnormal_skin_morphology3.29567828
10MP0004381_abnormal_hair_follicle3.28736773
11MP0010234_abnormal_vibrissa_follicle3.19793549
12MP0000427_abnormal_hair_cycle3.18634675
13MP0005501_abnormal_skin_physiology3.17916791
14MP0000678_abnormal_parathyroid_gland3.15029063
15MP0000383_abnormal_hair_follicle3.06628063
16MP0005275_abnormal_skin_tensile2.97995657
17MP0002009_preneoplasia2.97452002
18MP0001958_emphysema2.89564510
19MP0002249_abnormal_larynx_morphology2.86931343
20MP0000647_abnormal_sebaceous_gland2.80347451
21MP0004264_abnormal_extraembryonic_tissu2.77537589
22MP0002234_abnormal_pharynx_morphology2.77320622
23MP0001216_abnormal_epidermal_layer2.70536617
24MP0002098_abnormal_vibrissa_morphology2.67858252
25MP0010678_abnormal_skin_adnexa2.61694577
26MP0002132_abnormal_respiratory_system2.39186304
27MP0010771_integument_phenotype2.26122313
28MP0003950_abnormal_plasma_membrane2.16006565
29MP0000467_abnormal_esophagus_morphology2.15645079
30MP0001849_ear_inflammation2.14663618
31MP0003941_abnormal_skin_development2.12818442
32MP0005409_darkened_coat_color2.12154704
33MP0000003_abnormal_adipose_tissue2.11054349
34MP0003136_yellow_coat_color2.10470484
35MP0004947_skin_inflammation2.02000042
36MP0003453_abnormal_keratinocyte_physiol2.00840544
37MP0000377_abnormal_hair_follicle1.88664633
38MP0001851_eye_inflammation1.87297445
39MP0003566_abnormal_cell_adhesion1.76081402
40MP0003011_delayed_dark_adaptation1.69209494
41MP0005171_absent_coat_pigmentation1.63165852
42MP0002282_abnormal_trachea_morphology1.62756710
43MP0010030_abnormal_orbit_morphology1.61830292
44MP0009780_abnormal_chondrocyte_physiolo1.51724011
45MP0002332_abnormal_exercise_endurance1.51145019
46MP0009379_abnormal_foot_pigmentation1.48222054
47MP0009053_abnormal_anal_canal1.44344237
48MP0005375_adipose_tissue_phenotype1.43163608
49MP0005503_abnormal_tendon_morphology1.41271097
50MP0004142_abnormal_muscle_tone1.39977936
51MP0001191_abnormal_skin_condition1.35232075
52MP0010386_abnormal_urinary_bladder1.35187340
53MP0001243_abnormal_dermal_layer1.32090723
54MP0008789_abnormal_olfactory_epithelium1.22383736
55MP0000537_abnormal_urethra_morphology1.21620865
56MP0009931_abnormal_skin_appearance1.20307528
57MP0000566_synostosis1.19655986
58MP0002233_abnormal_nose_morphology1.17154855
59MP0000639_abnormal_adrenal_gland1.14472740
60MP0009250_abnormal_appendicular_skeleto1.12802957
61MP0003755_abnormal_palate_morphology1.11804267
62MP0001270_distended_abdomen1.11326243
63MP0001340_abnormal_eyelid_morphology1.10029776
64MP0004019_abnormal_vitamin_homeostasis1.09450086
65MP0000681_abnormal_thyroid_gland1.06974241
66MP0000569_abnormal_digit_pigmentation1.06304814
67MP0005187_abnormal_penis_morphology1.06173094
68MP0001299_abnormal_eye_distance/1.06061924
69MP0001188_hyperpigmentation1.02592504
70MP0000049_abnormal_middle_ear0.96701841
71MP0000367_abnormal_coat/_hair0.93588129
72MP0009384_cardiac_valve_regurgitation0.93216040
73MP0003786_premature_aging0.88050623
74MP0005499_abnormal_olfactory_system0.86638719
75MP0005394_taste/olfaction_phenotype0.86638719
76MP0000465_gastrointestinal_hemorrhage0.85781279
77MP0005623_abnormal_meninges_morphology0.85744251
78MP0000428_abnormal_craniofacial_morphol0.85012095
79MP0000538_abnormal_urinary_bladder0.81727963
80MP0001919_abnormal_reproductive_system0.81721933
81MP0005367_renal/urinary_system_phenotyp0.79243464
82MP0000516_abnormal_urinary_system0.79243464
83MP0002095_abnormal_skin_pigmentation0.78817448
84MP0002177_abnormal_outer_ear0.78365701
85MP0005666_abnormal_adipose_tissue0.76918809
86MP0000013_abnormal_adipose_tissue0.75131768
87MP0005508_abnormal_skeleton_morphology0.74619505
88MP0002166_altered_tumor_susceptibility0.74261371
89MP0002896_abnormal_bone_mineralization0.73328127
90MP0002168_other_aberrant_phenotype0.73309692
91MP0002133_abnormal_respiratory_system0.69363763
92MP0005388_respiratory_system_phenotype0.69363763
93MP0000627_abnormal_mammary_gland0.68919440
94MP0001348_abnormal_lacrimal_gland0.67225638
95MP0003279_aneurysm0.65859801
96MP0002108_abnormal_muscle_morphology0.65796347
97MP0000470_abnormal_stomach_morphology0.63907334
98MP0003300_gastrointestinal_ulcer0.63523283
99MP0004185_abnormal_adipocyte_glucose0.62987556
100MP0002909_abnormal_adrenal_gland0.62036028
101MP0003091_abnormal_cell_migration0.61960005
102MP0005076_abnormal_cell_differentiation0.61834552
103MP0000372_irregular_coat_pigmentation0.61526478
104MP0003123_paternal_imprinting0.61278522
105MP0010352_gastrointestinal_tract_polyps0.59815587
106MP0005023_abnormal_wound_healing0.59475813
107MP0005257_abnormal_intraocular_pressure0.59449633
108MP0008961_abnormal_basal_metabolism0.58207853
109MP0003191_abnormal_cellular_cholesterol0.57955478
110MP0000613_abnormal_salivary_gland0.57888805
111MP0000767_abnormal_smooth_muscle0.56889447
112MP0003935_abnormal_craniofacial_develop0.56850415
113MP0000751_myopathy0.56240915
114MP0003638_abnormal_response/metabolism_0.55943030
115MP0000371_diluted_coat_color0.55623817
116MP0004043_abnormal_pH_regulation0.55564315
117MP0002102_abnormal_ear_morphology0.53753719
118MP0006276_abnormal_autonomic_nervous0.53585365
119MP0002163_abnormal_gland_morphology0.53468867
120MP0003045_fibrosis0.52926505
121MP0002295_abnormal_pulmonary_circulatio0.52373021
122MP0005379_endocrine/exocrine_gland_phen0.51459319
123MP0001177_atelectasis0.51391974
124MP0005083_abnormal_biliary_tract0.51199997
125MP0006138_congestive_heart_failure0.51064119
126MP0001784_abnormal_fluid_regulation0.51034680
127MP0005166_decreased_susceptibility_to0.49931769
128MP0003075_altered_response_to0.48515755
129MP0004134_abnormal_chest_morphology0.48315968
130MP0005248_abnormal_Harderian_gland0.48267325
131MP0003122_maternal_imprinting0.47283171
132MP0005389_reproductive_system_phenotype0.46450772
133MP0003787_abnormal_imprinting0.45906183
134MP0002116_abnormal_craniofacial_bone0.45642025
135MP0003195_calcinosis0.45382920
136MP0002127_abnormal_cardiovascular_syste0.44894169
137MP0001666_abnormal_nutrient_absorption0.44714894
138MP0004272_abnormal_basement_membrane0.44444938
139MP0008872_abnormal_physiological_respon0.42775252
140MP0002006_tumorigenesis0.42014794
141MP0000163_abnormal_cartilage_morphology0.41190728
142MP0002277_abnormal_respiratory_mucosa0.41103983
143MP0001764_abnormal_homeostasis0.40350057
144MP0008057_abnormal_DNA_replication0.39122845
145MP0008004_abnormal_stomach_pH0.38977426
146MP0008770_decreased_survivor_rate0.36981573
147MP0002733_abnormal_thermal_nociception0.36458647
148MP0001175_abnormal_lung_morphology0.35541089
149MP0005395_other_phenotype0.35528462
150MP0005595_abnormal_vascular_smooth0.32353247
151MP0002136_abnormal_kidney_physiology0.31218895
152MP0003942_abnormal_urinary_system0.30593561
153MP0002160_abnormal_reproductive_system0.27950665
154MP0008260_abnormal_autophagy0.27019230

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)7.86816344
2Amyloidosis (HP:0011034)7.34122227
3Plantar hyperkeratosis (HP:0007556)7.21842546
4Duplicated collecting system (HP:0000081)6.04616361
5Onycholysis (HP:0001806)5.82172806
6Muscle fiber splitting (HP:0003555)5.79516487
7Hypotrichosis (HP:0001006)5.52414442
8Milia (HP:0001056)5.47888624
9Abnormal auditory evoked potentials (HP:0006958)5.41103668
10Abnormality of the renal collecting system (HP:0004742)5.28560159
11Entropion (HP:0000621)5.23083063
12Hypoplastic pelvis (HP:0008839)5.22988448
13Increased IgE level (HP:0003212)5.02026168
14Double outlet right ventricle (HP:0001719)4.93455896
15Congenital malformation of the right heart (HP:0011723)4.93455896
16Palmoplantar hyperkeratosis (HP:0000972)4.77815937
17Right ventricular cardiomyopathy (HP:0011663)4.64575848
18Palmar hyperkeratosis (HP:0010765)4.54811170
19Dry hair (HP:0011359)4.52680240
20Hypoplasia of the iris (HP:0007676)4.47562304
21Parakeratosis (HP:0001036)4.43557030
22Unilateral renal agenesis (HP:0000122)4.23269500
23Pili torti (HP:0003777)4.20732334
24Striae distensae (HP:0001065)4.18386494
25Atrophic scars (HP:0001075)4.13153976
26Erythema (HP:0010783)4.09766739
27Decreased lacrimation (HP:0000633)4.02051056
28Abnormal blistering of the skin (HP:0008066)3.95024710
29Woolly hair (HP:0002224)3.81639677
30Distal lower limb muscle weakness (HP:0009053)3.77074887
31Poikiloderma (HP:0001029)3.76896917
32Abnormality of DNA repair (HP:0003254)3.73637597
33Reduced subcutaneous adipose tissue (HP:0003758)3.73129238
34Down-sloping shoulders (HP:0200021)3.67667281
35Neoplasm of the heart (HP:0100544)3.49692498
36Soft skin (HP:0000977)3.49029435
37Nail dystrophy (HP:0008404)3.47314084
38Ureteral duplication (HP:0000073)3.45261312
39Abnormality of the aortic arch (HP:0012303)3.42266909
40Concave nail (HP:0001598)3.41642996
41Keratoconjunctivitis sicca (HP:0001097)3.32416115
42Abnormality of the distal phalanx of the thumb (HP:0009617)3.25093367
43Dilatation of the ascending aorta (HP:0005111)3.23546201
44Severe short stature (HP:0003510)3.13456202
45Abnormality of the parathyroid morphology (HP:0011766)3.13198852
46Malnutrition (HP:0004395)3.06632864
47Keratitis (HP:0000491)3.06539052
48Keratoconjunctivitis (HP:0001096)3.02730273
49Anhidrosis (HP:0000970)3.02688578
50Premature skin wrinkling (HP:0100678)3.01868847
51Sparse eyelashes (HP:0000653)3.01748454
52Conical tooth (HP:0000698)3.00876866
53Mitral valve prolapse (HP:0001634)3.00035298
54Bronchomalacia (HP:0002780)2.96362810
55Short nail (HP:0001799)2.87773365
56Erythroderma (HP:0001019)2.87493922
57Conjunctival hamartoma (HP:0100780)2.87120500
58Ridged nail (HP:0001807)2.86239967
59Cystic hygroma (HP:0000476)2.85022562
60Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.84238611
61Palpitations (HP:0001962)2.77613693
62Oligodontia (HP:0000677)2.73739640
63Natal tooth (HP:0000695)2.71857872
64Broad face (HP:0000283)2.67775044
65Alopecia of scalp (HP:0002293)2.66561249
66Abnormality of secondary sexual hair (HP:0009888)2.66309274
67Abnormality of the axillary hair (HP:0100134)2.66309274
68Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.59272980
69Seborrheic dermatitis (HP:0001051)2.58132309
70Short 4th metacarpal (HP:0010044)2.56023246
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.56023246
72Hypodontia (HP:0000668)2.55883812
73Hypercortisolism (HP:0001578)2.52924117
74Advanced eruption of teeth (HP:0006288)2.52448627
75Flat acetabular roof (HP:0003180)2.52431381
76Aplasia cutis congenita (HP:0001057)2.51506976
77Abnormality of the nasal septum (HP:0000419)2.51496746
78Pruritus (HP:0000989)2.50998532
79Abnormal hair laboratory examination (HP:0003328)2.49889464
80Hyperthyroidism (HP:0000836)2.43593050
81Xerostomia (HP:0000217)2.43082778
82Abnormality of the proximal phalanges of the hand (HP:0009834)2.42966225
83Esophageal atresia (HP:0002032)2.41691701
8411 pairs of ribs (HP:0000878)2.40932510
85Hoarse voice (HP:0001609)2.40517388
86Fragile skin (HP:0001030)2.37457823
87Cervical subluxation (HP:0003308)2.35558108
88Abnormality of the phalanges of the 5th finger (HP:0004213)2.35305225
89Hypoplastic labia majora (HP:0000059)2.30709034
90Abnormality of cells of the erythroid lineage (HP:0012130)2.30057761
91Ectropion (HP:0000656)2.28784744
92Medulloblastoma (HP:0002885)2.28513859
93Ankyloglossia (HP:0010296)2.27462740
94Lack of skin elasticity (HP:0100679)2.27344622
95Hypohidrosis (HP:0000966)2.26006311
96Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.25479970
97Alacrima (HP:0000522)2.24458506
98Proximal amyotrophy (HP:0007126)2.24071126
99Abnormal hand bone ossification (HP:0010660)2.22247618
100Distal lower limb amyotrophy (HP:0008944)2.22141534
101Overgrowth (HP:0001548)2.19424874
102Thin bony cortex (HP:0002753)2.18443954
103Short phalanx of the thumb (HP:0009660)2.17613130
104Fibular aplasia (HP:0002990)2.17496504
105Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.17406396
106Gingivitis (HP:0000230)2.17370818
107Skin pits (HP:0100276)2.16520600
108Hypoplasia of dental enamel (HP:0006297)2.15344273
109Thick nail (HP:0001805)2.15220165
110Mixed hearing impairment (HP:0000410)2.13584237
111Deformed sella turcica (HP:0002681)2.13040463
112Absent eyebrow (HP:0002223)2.12114138
113Abnormal ossification of hand bones (HP:0005921)2.11999947
114Lip pit (HP:0100267)2.10877423
115Corneal erosion (HP:0200020)2.10586381
116Bicornuate uterus (HP:0000813)2.09521122
117Basal ganglia calcification (HP:0002135)2.08167357
118Premature loss of primary teeth (HP:0006323)2.08063844
119Recurrent corneal erosions (HP:0000495)2.07548796
120Abnormality of the labia majora (HP:0012881)2.06629860
121Hypoplastic ilia (HP:0000946)2.05912692
122Preauricular pit (HP:0004467)2.04888277
123Periauricular skin pits (HP:0100277)2.04888277
124Hyporeflexia of lower limbs (HP:0002600)2.02421088
125Overfolded helix (HP:0000396)2.02293570
126Carious teeth (HP:0000670)2.02027354
127Exotropia (HP:0000577)2.00857213
128Abnormality of the parietal bone (HP:0002696)2.00671173
129Aortic dissection (HP:0002647)2.00669262
130Gangrene (HP:0100758)1.98211265
131Spinal cord compression (HP:0002176)1.98122437
132Neonatal short-limb short stature (HP:0008921)1.98096170
133Abnormality of nail color (HP:0100643)1.97939113
134Stenosis of the external auditory canal (HP:0000402)1.97825014
135Ventricular tachycardia (HP:0004756)1.96947664
136Supernumerary ribs (HP:0005815)1.95530153
137Aplasia involving bones of the extremities (HP:0009825)1.94752667
138Aplasia involving bones of the upper limbs (HP:0009823)1.94752667
139Aplasia of the phalanges of the hand (HP:0009802)1.94752667
140Neonatal death (HP:0003811)1.91334331
141Short chin (HP:0000331)1.91302446
142Hypoplastic iliac wings (HP:0002866)1.90893490
143Symphalangism affecting the phalanges of the hand (HP:0009773)1.90628039
144Hyperhidrosis (HP:0000975)1.89897036
145Increased connective tissue (HP:0009025)1.89023130
146Wormian bones (HP:0002645)1.88788288
147Shallow orbits (HP:0000586)1.88679107
148Neoplasm of the oral cavity (HP:0100649)1.88636883
149Pustule (HP:0200039)1.88610716
150Epiphyseal dysplasia (HP:0002656)1.88548768
151Intrahepatic cholestasis (HP:0001406)1.86876449
152Abnormally folded helix (HP:0008544)1.85879763
153Acanthosis nigricans (HP:0000956)1.85241198
154Congenital sensorineural hearing impairment (HP:0008527)1.84684324
155Tibial bowing (HP:0002982)1.84576490
156Sparse scalp hair (HP:0002209)1.83524131
157Aplasia/Hypoplasia of the earlobes (HP:0009906)1.80983819
158Short palpebral fissure (HP:0012745)1.80175514
159Truncus arteriosus (HP:0001660)1.78169161
160Tetany (HP:0001281)1.77857250
161Renal agenesis (HP:0000104)1.77793820
162Upper limb muscle weakness (HP:0003484)1.75472941
163Palmoplantar keratoderma (HP:0000982)1.75391575
164Widely patent fontanelles and sutures (HP:0004492)1.74613481
165Synostosis involving the elbow (HP:0003938)1.73181320
166Humeroradial synostosis (HP:0003041)1.73181320
167Chin dimple (HP:0010751)1.71531910
168Hypertensive crisis (HP:0100735)1.71015602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR25.14549497
2MST44.65502418
3EPHA24.36740437
4WNK13.54007847
5MAP3K133.16141667
6MST1R3.06755949
7EPHB22.91587297
8BCR2.90299555
9MAP3K62.87541510
10FER2.70724038
11LATS12.60804664
12PKN22.51863206
13ERN12.41092853
14FGFR12.28278476
15PBK2.24683575
16TTN2.03634730
17MAPKAPK31.99365229
18MAP3K141.83904354
19FGFR41.79998664
20EPHA31.74897970
21NEK91.60152887
22MAP3K71.52157647
23LRRK21.51213820
24MAP2K21.50526186
25RPS6KB21.45087831
26DAPK11.39447277
27DAPK21.38583045
28FLT31.38323259
29NME11.38261770
30SIK11.35810865
31STK38L1.35586933
32PDGFRB1.34340378
33MAP3K31.33710798
34HIPK21.30184785
35STK241.29706962
36EPHB11.28107737
37MAP2K11.24684173
38STK111.23578626
39NTRK21.21875798
40STK381.18552328
41RPS6KA21.18529730
42LATS21.18026195
43TYRO31.17832187
44SGK2231.09754455
45SGK4941.09754455
46PIK3CG1.05569222
47CDC42BPA1.03784721
48FGFR31.03063761
49PRKD11.02909653
50NTRK11.02638464
51MAPK111.01472856
52MAP3K20.99457633
53BMPR1B0.99356316
54MAP3K120.98003714
55CDK60.95698478
56STK100.92099073
57MAPKAPK50.91667948
58MAP2K40.89929855
59EEF2K0.89210196
60DAPK30.89074294
61STK30.83503932
62TYK20.81192471
63EPHA40.80492234
64PTK60.80207422
65MAPKAPK20.80080172
66PIK3CA0.79709444
67ROCK10.79396566
68CDK30.79250469
69BLK0.79207268
70CSK0.77695146
71AKT20.77376135
72PKN10.75808957
73RPS6KL10.73707838
74RPS6KC10.73707838
75GRK10.73336903
76MTOR0.73181695
77MAP3K10.72401377
78DYRK1B0.69713173
79TGFBR10.69681140
80RIPK10.69606423
81SGK20.68972413
82SGK30.68874364
83RPS6KA60.68291761
84MAP3K90.68261253
85TGFBR20.66605617
86MAPK120.66297807
87NME20.64552130
88ERBB30.64362461
89PRKCI0.64285591
90PAK60.62850905
91PDGFRA0.62214516
92IKBKB0.62199029
93PRKAA20.60794025
94CAMK1D0.60641673
95MAPK40.59921530
96CSNK1D0.59640782
97CHUK0.58879125
98TRPM70.58858484
99BMX0.57869943
100PDK20.57541647
101PHKG20.56427380
102PHKG10.56427380
103ITK0.56099199
104PLK40.53579232
105PAK30.52889921
106OBSCN0.52016794
107KSR20.50255261
108MINK10.49960605
109ZAK0.49111926
110FRK0.48357668
111TIE10.48204763
112RIPK40.47147908
113PRKACA0.46727410
114ROCK20.46513905
115RET0.46366056
116PRKCE0.45432386
117RPS6KA50.45123529
118ERBB20.44915798
119RPS6KA10.43527201
120MAP3K110.42974217
121MET0.42418856
122MAPK70.42396955
123ABL10.42089222
124PRKCA0.40116323
125CAMK2A0.38704260
126MAPK30.36921470
127FYN0.36711084
128PTK20.36169783
129SGK10.35541678
130MKNK10.35277604
131CSNK1G20.34585107
132HCK0.34003122
133JAK10.33892936
134IRAK20.33794076
135NLK0.33682303
136EIF2AK20.33560194
137CLK10.32446482
138CAMK1G0.31912149
139BRSK20.31375453
140PRKD20.29398086
141PRKACB0.28666810
142CAMK2G0.28157078
143MARK20.26560465
144IGF1R0.26246323
145EGFR0.23724469
146CSNK1E0.21963037
147MAPK10.21638604
148CAMK2B0.21587573
149ADRBK10.20746252
150AURKB0.19641626
151FGR0.19123365
152PTK2B0.18364947
153IKBKE0.17964954
154BTK0.16065307
155EIF2AK30.16016333
156PRKG10.14693379
157SRC0.14221193

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.43915189
2Ribosome_Homo sapiens_hsa030103.00560479
3Basal cell carcinoma_Homo sapiens_hsa052172.56624776
4Salivary secretion_Homo sapiens_hsa049702.36247840
5Retinol metabolism_Homo sapiens_hsa008302.35286836
6Gastric acid secretion_Homo sapiens_hsa049712.23742774
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.15953136
8Phototransduction_Homo sapiens_hsa047442.10933292
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01055402
10Bladder cancer_Homo sapiens_hsa052192.00195869
11ECM-receptor interaction_Homo sapiens_hsa045121.85517966
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.83301120
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77520277
14Renin secretion_Homo sapiens_hsa049241.71353566
15Renal cell carcinoma_Homo sapiens_hsa052111.66541945
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.65386483
17Hippo signaling pathway_Homo sapiens_hsa043901.59885310
18Circadian rhythm_Homo sapiens_hsa047101.59472575
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59069254
20Protein digestion and absorption_Homo sapiens_hsa049741.58800654
21Phenylalanine metabolism_Homo sapiens_hsa003601.55462527
22Axon guidance_Homo sapiens_hsa043601.54234218
23Melanogenesis_Homo sapiens_hsa049161.49563412
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43336984
25Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40433600
26MicroRNAs in cancer_Homo sapiens_hsa052061.38643371
27Amoebiasis_Homo sapiens_hsa051461.37692432
28Hedgehog signaling pathway_Homo sapiens_hsa043401.36229432
29Fatty acid degradation_Homo sapiens_hsa000711.35628191
30Endocytosis_Homo sapiens_hsa041441.35377560
31PPAR signaling pathway_Homo sapiens_hsa033201.35284647
32Nucleotide excision repair_Homo sapiens_hsa034201.35235765
33TGF-beta signaling pathway_Homo sapiens_hsa043501.33977604
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23843150
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23157732
36Dilated cardiomyopathy_Homo sapiens_hsa054141.20217046
37Histidine metabolism_Homo sapiens_hsa003401.19836938
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18301012
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18233755
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13677050
41Choline metabolism in cancer_Homo sapiens_hsa052311.13321191
42Tyrosine metabolism_Homo sapiens_hsa003501.13208236
43Olfactory transduction_Homo sapiens_hsa047401.13026943
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12891702
45Fatty acid elongation_Homo sapiens_hsa000621.12768886
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12243299
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11878671
48Proteoglycans in cancer_Homo sapiens_hsa052051.11748663
49Calcium signaling pathway_Homo sapiens_hsa040201.08580373
50Prolactin signaling pathway_Homo sapiens_hsa049171.08143276
51Rap1 signaling pathway_Homo sapiens_hsa040151.07639384
52Wnt signaling pathway_Homo sapiens_hsa043101.05523827
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.03017002
54Salmonella infection_Homo sapiens_hsa051321.02346949
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02290424
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01882501
57Dopaminergic synapse_Homo sapiens_hsa047281.01029297
58Chemical carcinogenesis_Homo sapiens_hsa052040.99300286
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.98627276
60Galactose metabolism_Homo sapiens_hsa000520.98167758
61GnRH signaling pathway_Homo sapiens_hsa049120.96333695
62Ether lipid metabolism_Homo sapiens_hsa005650.95279817
63Long-term depression_Homo sapiens_hsa047300.92560792
64Nitrogen metabolism_Homo sapiens_hsa009100.92458180
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.90829770
66Mineral absorption_Homo sapiens_hsa049780.90284625
67Oxytocin signaling pathway_Homo sapiens_hsa049210.89046865
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88528178
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88194196
70HIF-1 signaling pathway_Homo sapiens_hsa040660.87221812
71Ovarian steroidogenesis_Homo sapiens_hsa049130.86496531
72Circadian entrainment_Homo sapiens_hsa047130.86450229
73Taste transduction_Homo sapiens_hsa047420.85499371
74Linoleic acid metabolism_Homo sapiens_hsa005910.85467236
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84582507
76Inositol phosphate metabolism_Homo sapiens_hsa005620.82318221
77Glucagon signaling pathway_Homo sapiens_hsa049220.81182221
78Long-term potentiation_Homo sapiens_hsa047200.79836713
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.79683255
80Pathways in cancer_Homo sapiens_hsa052000.79459650
81cAMP signaling pathway_Homo sapiens_hsa040240.79341487
82Tight junction_Homo sapiens_hsa045300.79190530
83Fructose and mannose metabolism_Homo sapiens_hsa000510.78434355
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.76943155
85Amphetamine addiction_Homo sapiens_hsa050310.76918950
86Ras signaling pathway_Homo sapiens_hsa040140.74844872
87Serotonergic synapse_Homo sapiens_hsa047260.74496021
88Malaria_Homo sapiens_hsa051440.73829040
89Notch signaling pathway_Homo sapiens_hsa043300.73066734
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72453952
91Arachidonic acid metabolism_Homo sapiens_hsa005900.72066643
92Dorso-ventral axis formation_Homo sapiens_hsa043200.70857597
93Sphingolipid metabolism_Homo sapiens_hsa006000.70736971
94Pancreatic cancer_Homo sapiens_hsa052120.70363706
95Small cell lung cancer_Homo sapiens_hsa052220.69414567
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68013792
97Glioma_Homo sapiens_hsa052140.67618587
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67452592
99Adherens junction_Homo sapiens_hsa045200.67246672
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67192726
101p53 signaling pathway_Homo sapiens_hsa041150.64447327
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63834692
103Caffeine metabolism_Homo sapiens_hsa002320.63635059
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.62827701
105MAPK signaling pathway_Homo sapiens_hsa040100.62167392
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.62128325
107Toxoplasmosis_Homo sapiens_hsa051450.59450727
108Pancreatic secretion_Homo sapiens_hsa049720.58980090
109ABC transporters_Homo sapiens_hsa020100.58858046
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58259068
111HTLV-I infection_Homo sapiens_hsa051660.57725802
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56699423
113Focal adhesion_Homo sapiens_hsa045100.55256643
114Bile secretion_Homo sapiens_hsa049760.55039926
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54614384
116Nicotine addiction_Homo sapiens_hsa050330.54170180
117Regulation of autophagy_Homo sapiens_hsa041400.54114438
118Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52951301
119Insulin resistance_Homo sapiens_hsa049310.52608607
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52137870
121Thyroid cancer_Homo sapiens_hsa052160.51239644
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51150184
123Fatty acid biosynthesis_Homo sapiens_hsa000610.50852876
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50405716
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.50120418
126VEGF signaling pathway_Homo sapiens_hsa043700.49789289
127Glutamatergic synapse_Homo sapiens_hsa047240.49765230
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49206684
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48403178
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.48156626
131Platelet activation_Homo sapiens_hsa046110.47686310
132Hepatitis C_Homo sapiens_hsa051600.47186456
133Gap junction_Homo sapiens_hsa045400.46826529
134TNF signaling pathway_Homo sapiens_hsa046680.46770618
135Estrogen signaling pathway_Homo sapiens_hsa049150.46617765
136Graft-versus-host disease_Homo sapiens_hsa053320.46471912
137Staphylococcus aureus infection_Homo sapiens_hsa051500.46278981
138ErbB signaling pathway_Homo sapiens_hsa040120.46254178
139Fat digestion and absorption_Homo sapiens_hsa049750.46091525
140Starch and sucrose metabolism_Homo sapiens_hsa005000.45485365
141Insulin signaling pathway_Homo sapiens_hsa049100.44544104
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44340118
143Tuberculosis_Homo sapiens_hsa051520.44281133
144Vitamin digestion and absorption_Homo sapiens_hsa049770.43886730
145Melanoma_Homo sapiens_hsa052180.42717955
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40958747
147Lysine degradation_Homo sapiens_hsa003100.40769950
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39520324
149mTOR signaling pathway_Homo sapiens_hsa041500.38075117
150AMPK signaling pathway_Homo sapiens_hsa041520.37376567
151Shigellosis_Homo sapiens_hsa051310.37251070
152Endometrial cancer_Homo sapiens_hsa052130.36712371
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33239918

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