KRT25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)9.44011057
2* intermediate filament organization (GO:0045109)9.19180268
3adhesion of symbiont to host (GO:0044406)9.04622710
4peptide cross-linking (GO:0018149)8.79330537
5linoleic acid metabolic process (GO:0043651)7.58170752
6cell wall macromolecule metabolic process (GO:0044036)6.62361423
7cell wall macromolecule catabolic process (GO:0016998)6.62361423
8* hair follicle morphogenesis (GO:0031069)6.56810316
9epidermis development (GO:0008544)6.54219855
10long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.47093878
11citrulline metabolic process (GO:0000052)6.25575731
12long-chain fatty-acyl-CoA metabolic process (GO:0035336)6.13533236
13keratinocyte differentiation (GO:0030216)6.10733508
14very long-chain fatty acid metabolic process (GO:0000038)6.03830754
15fatty-acyl-CoA biosynthetic process (GO:0046949)5.76914502
16establishment of skin barrier (GO:0061436)5.57225445
17bundle of His cell to Purkinje myocyte communication (GO:0086069)5.56864951
18retinol metabolic process (GO:0042572)5.26049228
19peptidyl-arginine modification (GO:0018195)5.26008553
20* intermediate filament cytoskeleton organization (GO:0045104)5.15903887
21hemidesmosome assembly (GO:0031581)5.06456753
22* intermediate filament-based process (GO:0045103)4.98106094
23regulation of water loss via skin (GO:0033561)4.96734977
24* molting cycle process (GO:0022404)4.93422821
25* hair cycle process (GO:0022405)4.93422821
26skin morphogenesis (GO:0043589)4.93084055
27fatty-acyl-CoA metabolic process (GO:0035337)4.83677530
28epidermal cell differentiation (GO:0009913)4.82483297
29thioester biosynthetic process (GO:0035384)4.73717958
30acyl-CoA biosynthetic process (GO:0071616)4.73717958
31long-chain fatty acid biosynthetic process (GO:0042759)4.67432003
32tooth mineralization (GO:0034505)4.33386731
33alpha-linolenic acid metabolic process (GO:0036109)4.21492459
34positive regulation of keratinocyte differentiation (GO:0045618)4.15650777
35keratinocyte development (GO:0003334)4.06138082
36* molting cycle (GO:0042303)33.6178805
37* hair cycle (GO:0042633)33.6178805
38positive regulation of chemokine secretion (GO:0090197)3.92057993
39primary alcohol metabolic process (GO:0034308)3.87436042
40lipoxygenase pathway (GO:0019372)3.79153626
41hair follicle development (GO:0001942)3.71983422
42positive regulation of hair follicle development (GO:0051798)3.69930947
43positive regulation of hair cycle (GO:0042635)3.69930947
44negative regulation of keratinocyte proliferation (GO:0010839)3.62500837
45defense response to fungus (GO:0050832)3.55363039
46regulation of chemokine secretion (GO:0090196)3.54918435
47regulation of hair follicle development (GO:0051797)3.51810035
48regulation of keratinocyte differentiation (GO:0045616)3.47646629
49negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.46848312
50bone trabecula formation (GO:0060346)3.42693907
51phosphatidylinositol acyl-chain remodeling (GO:0036149)3.40191228
52triglyceride biosynthetic process (GO:0019432)3.38444260
53multicellular organismal water homeostasis (GO:0050891)3.36690939
54killing of cells of other organism (GO:0031640)3.21849418
55disruption of cells of other organism (GO:0044364)3.21849418
56neutral lipid biosynthetic process (GO:0046460)3.19561282
57acylglycerol biosynthetic process (GO:0046463)3.19561282
58epithelium development (GO:0060429)3.12437560
59phosphatidylserine acyl-chain remodeling (GO:0036150)3.10565140
60regulation of hair cycle (GO:0042634)3.10124437
61regulation of sequestering of triglyceride (GO:0010889)3.08513451
62positive regulation of meiotic cell cycle (GO:0051446)3.03026844
63gap junction assembly (GO:0016264)3.01383423
64positive regulation of epidermis development (GO:0045684)2.99536098
65ectoderm development (GO:0007398)2.93876457
66epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.93711906
67atrioventricular valve morphogenesis (GO:0003181)2.87367474
68thioester metabolic process (GO:0035383)2.87097995
69acyl-CoA metabolic process (GO:0006637)2.87097995
70negative regulation of protein localization to plasma membrane (GO:1903077)2.86641868
71phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.85577091
72primary alcohol catabolic process (GO:0034310)2.79079047
73regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.77249775
74water homeostasis (GO:0030104)2.74009594
75response to phenylpropanoid (GO:0080184)2.72615899
76carnitine metabolic process (GO:0009437)2.72120234
77fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.70503082
78regulation of epidermal cell differentiation (GO:0045604)2.69686544
79regulation of epidermis development (GO:0045682)2.65704073
80one-carbon compound transport (GO:0019755)2.61514580
81cranial suture morphogenesis (GO:0060363)2.61137968
82cell surface receptor signaling pathway involved in heart development (GO:0061311)2.58859172
83wound healing, spreading of epidermal cells (GO:0035313)2.57024994
84ventricular cardiac muscle cell action potential (GO:0086005)2.55885403
85regulation of mesenchymal cell apoptotic process (GO:2001053)2.50152126
86negative regulation of cell fate specification (GO:0009996)2.49312513
87fatty acid elongation (GO:0030497)2.49253253
88positive regulation of epidermal cell differentiation (GO:0045606)2.38951440
89epithelial cell differentiation involved in prostate gland development (GO:0060742)2.36734922
90negative regulation of epidermis development (GO:0045683)2.33712685
91phosphatidylserine metabolic process (GO:0006658)2.33605813
92unsaturated fatty acid biosynthetic process (GO:0006636)2.33551096
93planar cell polarity pathway involved in neural tube closure (GO:0090179)2.27990201
94outflow tract septum morphogenesis (GO:0003148)2.27852697
95phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.27027125
96detection of bacterium (GO:0016045)2.26101702
97lymph vessel development (GO:0001945)2.25939550
98skin development (GO:0043588)2.25846553
99fatty acid biosynthetic process (GO:0006633)2.25148734
100regulation of defense response to virus by host (GO:0050691)2.24228959
101response to fungus (GO:0009620)2.20725182
102ethanol metabolic process (GO:0006067)2.19110400
103negative regulation of execution phase of apoptosis (GO:1900118)2.17305518
104regulation of heart rate by cardiac conduction (GO:0086091)2.16156846
105regulation of cardioblast differentiation (GO:0051890)2.14079445
106positive regulation of monocyte chemotaxis (GO:0090026)2.13316983
107regulation of keratinocyte proliferation (GO:0010837)2.11453466
108epithelial cell-cell adhesion (GO:0090136)2.10861574
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.10800958
110regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.10755264
111myotube differentiation (GO:0014902)2.08217916
112phosphatidic acid biosynthetic process (GO:0006654)2.06670848
113phosphatidic acid metabolic process (GO:0046473)2.06670848
114non-canonical Wnt signaling pathway (GO:0035567)2.06288390
115regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.05341556
116cell communication involved in cardiac conduction (GO:0086065)2.02512263
117regulation of phospholipase A2 activity (GO:0032429)2.00262339
118detection of other organism (GO:0098543)2.00077385
119keratinization (GO:0031424)11.3950455
120desmosome organization (GO:0002934)10.9582141
121virion attachment to host cell (GO:0019062)10.7127402
122adhesion of symbiont to host cell (GO:0044650)10.7127402
123phosphatidylcholine acyl-chain remodeling (GO:0036151)1.99128818
124regulation of ruffle assembly (GO:1900027)1.98756958
125regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.95370582
126ephrin receptor signaling pathway (GO:0048013)1.93563520
127craniofacial suture morphogenesis (GO:0097094)1.88320727
128regulation of natural killer cell differentiation (GO:0032823)1.88234827
129cell-substrate junction assembly (GO:0007044)1.86907061
130G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.86481225
131lateral sprouting from an epithelium (GO:0060601)1.84831250
132regulation of transforming growth factor beta2 production (GO:0032909)1.83512486
133coronary vasculature morphogenesis (GO:0060977)1.83356184
134amino-acid betaine metabolic process (GO:0006577)1.83245617
135negative regulation of epidermal cell differentiation (GO:0045605)1.82770600
136establishment of planar polarity (GO:0001736)1.82600236
137establishment of tissue polarity (GO:0007164)1.82600236
138positive regulation of macrophage derived foam cell differentiation (GO:0010744)1.81411650
139wound healing, spreading of cells (GO:0044319)1.78435733
140* aging (GO:0007568)1.77139097
141eyelid development in camera-type eye (GO:0061029)1.76668837
142keratinocyte proliferation (GO:0043616)1.75977386
143regulation of cardioblast proliferation (GO:0003264)1.72203080
144regulation of secondary heart field cardioblast proliferation (GO:0003266)1.72203080
145odontogenesis of dentin-containing tooth (GO:0042475)1.72096709
146alditol phosphate metabolic process (GO:0052646)1.70656459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.19921387
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.05178193
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.57069828
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.84119340
5CTCF_20526341_ChIP-Seq_ESCs_Human2.26922693
6NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.15362434
7BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.14165682
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.8305681
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.87121050
10TAF2_19829295_ChIP-Seq_ESCs_Human1.78304755
11SOX9_24532713_ChIP-Seq_HFSC_Mouse1.77154920
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.72386221
13EGR1_19032775_ChIP-ChIP_M12_Human1.71805617
14CSB_26484114_Chip-Seq_FIBROBLAST_Human1.69433280
15NANOG_20526341_ChIP-Seq_ESCs_Human1.66821464
16* E2F1_20622854_ChIP-Seq_HELA_Human1.66087823
17FOXO3_23340844_ChIP-Seq_DLD1_Human1.59216111
18CTCF_27219007_Chip-Seq_Bcells_Human1.57462013
19ERG_20517297_ChIP-Seq_VCAP_Human1.56153207
20P53_21459846_ChIP-Seq_SAOS-2_Human1.55057807
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55020156
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55020156
23TP53_20018659_ChIP-ChIP_R1E_Mouse1.55010392
24MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.53421740
25* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.52239707
26RACK7_27058665_Chip-Seq_MCF-7_Human1.51474700
27DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45106739
28LXR_22292898_ChIP-Seq_THP-1_Human1.44966406
29BCL6_27268052_Chip-Seq_Bcells_Human1.42983876
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.42280807
31* TP63_22573176_ChIP-Seq_HFKS_Human1.41548216
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.38227253
33ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37999440
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37711162
35ATF3_27146783_Chip-Seq_COLON_Human1.36205947
36BCOR_27268052_Chip-Seq_Bcells_Human1.33998304
37AHR_22903824_ChIP-Seq_MCF-7_Human1.33576446
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33567105
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.33549741
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29115199
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.27377865
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26061863
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18941495
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18432611
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.17746595
46P68_20966046_ChIP-Seq_HELA_Human1.16360859
47CEBPB_22108803_ChIP-Seq_LS180_Human1.15217495
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14657967
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.13872144
50E2F1_17053090_ChIP-ChIP_MCF-7_Human1.13151421
51UBF1/2_26484160_Chip-Seq_HMECs_Human1.11835767
52GATA3_24758297_ChIP-Seq_MCF-7_Human1.11214364
53ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09804307
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08990061
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08622134
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07893669
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07513705
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07188427
59RAC3_21632823_ChIP-Seq_H3396_Human1.06964046
60GATA4_25053715_ChIP-Seq_YYC3_Human1.06454291
61* PHF8_20622854_ChIP-Seq_HELA_Human1.06007682
62SMC4_20622854_ChIP-Seq_HELA_Human1.05848709
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05205787
64JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04976561
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04645396
66* TP63_23658742_ChIP-Seq_EP156T_Human1.04199688
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02466442
68KLF5_25053715_ChIP-Seq_YYC3_Human1.01644846
69SA1_27219007_Chip-Seq_ERYTHROID_Human0.99961523
70TP53_18474530_ChIP-ChIP_U2OS_Human0.99948795
71SOX2_21211035_ChIP-Seq_LN229_Human0.97658010
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96780411
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96199079
74SPI1_20517297_ChIP-Seq_HL60_Human0.96042360
75RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95024155
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93719942
77ERG_21242973_ChIP-ChIP_JURKAT_Human0.93479601
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92903467
79RXR_22108803_ChIP-Seq_LS180_Human0.91481204
80RUNX1_27514584_Chip-Seq_MCF-7_Human0.90222166
81FOXH1_21741376_ChIP-Seq_ESCs_Human0.89759928
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89561276
83RING1B_27294783_Chip-Seq_ESCs_Mouse0.89411343
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89058918
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88483866
86ESR1_20079471_ChIP-ChIP_T-47D_Human0.87997367
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.85490712
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85463055
89RNF2_27304074_Chip-Seq_ESCs_Mouse0.84971818
90AR_21572438_ChIP-Seq_LNCaP_Human0.83590981
91SOX2_20726797_ChIP-Seq_SW620_Human0.83423312
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.82823950
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82624918
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81288713
95ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80892346
96ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79777184
97CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.79156129
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.77838450
99ZNF263_19887448_ChIP-Seq_K562_Human0.77777471
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.76207229
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76065977
102FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75923908
103ELK3_25401928_ChIP-Seq_HUVEC_Human0.75483216
104* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.74203355
105* FOXA1_25329375_ChIP-Seq_VCAP_Human0.74203355
106HTT_18923047_ChIP-ChIP_STHdh_Human0.74115789
107TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.73186681
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.72924805
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71586761
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71586761
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.71486460
112KAP1_27257070_Chip-Seq_ESCs_Mouse0.69816904
113SMAD4_21741376_ChIP-Seq_ESCs_Human0.69624072
114HNFA_21074721_ChIP-Seq_CACO-2_Human0.69529550
115EZH2_27304074_Chip-Seq_ESCs_Mouse0.68564250
116STAT1_20625510_ChIP-Seq_HELA_Human0.68464033
117MYC_19829295_ChIP-Seq_ESCs_Human0.66152780
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65260054
119ERA_21632823_ChIP-Seq_H3396_Human0.63555788
120FOXH1_21741376_ChIP-Seq_EPCs_Human0.63475106
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.63360345
122PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.63172461
123SA1_27219007_Chip-Seq_Bcells_Human0.62962181
124PHF8_20622853_ChIP-Seq_HELA_Human0.61679115
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.60966864
126RBPJ_21746931_ChIP-Seq_IB4_Human0.60841509
127JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.60110773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology8.16030728
2* MP0002098_abnormal_vibrissa_morphology6.52179522
3MP0002796_impaired_skin_barrier5.72176314
4* MP0000647_abnormal_sebaceous_gland5.44251022
5MP0005275_abnormal_skin_tensile5.24062159
6MP0010234_abnormal_vibrissa_follicle5.12922638
7MP0000383_abnormal_hair_follicle5.10920556
8MP0010678_abnormal_skin_adnexa4.48122757
9MP0000427_abnormal_hair_cycle3.84954522
10* MP0000377_abnormal_hair_follicle3.76983055
11MP0003705_abnormal_hypodermis_morpholog3.73238156
12MP0005501_abnormal_skin_physiology3.56944379
13MP0002254_reproductive_system_inflammat3.17510518
14MP0001216_abnormal_epidermal_layer2.71910245
15MP0004381_abnormal_hair_follicle2.55846064
16MP0003878_abnormal_ear_physiology2.42312899
17MP0005377_hearing/vestibular/ear_phenot2.42312899
18MP0001243_abnormal_dermal_layer2.33771609
19MP0010771_integument_phenotype2.32006914
20MP0004947_skin_inflammation2.30782924
21* MP0000367_abnormal_coat/_hair2.24147998
22MP0003453_abnormal_keratinocyte_physiol2.20215534
23MP0002060_abnormal_skin_morphology2.17694765
24MP0002234_abnormal_pharynx_morphology1.96138006
25MP0001188_hyperpigmentation1.89364415
26MP0003011_delayed_dark_adaptation1.78391222
27MP0000467_abnormal_esophagus_morphology1.71407777
28MP0009053_abnormal_anal_canal1.58316678
29MP0000762_abnormal_tongue_morphology1.55164955
30MP0005409_darkened_coat_color1.54324542
31MP0009931_abnormal_skin_appearance1.51318751
32MP0003566_abnormal_cell_adhesion1.44371273
33MP0003941_abnormal_skin_development1.25003053
34MP0005647_abnormal_sex_gland1.10044043
35MP0005174_abnormal_tail_pigmentation1.03154799
36MP0000015_abnormal_ear_pigmentation1.02046720
37MP0001661_extended_life_span1.00728540
38MP0001191_abnormal_skin_condition1.00470590
39MP0002095_abnormal_skin_pigmentation0.98006316
40MP0004885_abnormal_endolymph0.97602698
41MP0004264_abnormal_extraembryonic_tissu0.90510389
42MP0004185_abnormal_adipocyte_glucose0.86047018
43MP0006035_abnormal_mitochondrial_morpho0.84871377
44MP0008438_abnormal_cutaneous_collagen0.80340012
45MP0000566_synostosis0.79779765
46MP0001851_eye_inflammation0.78691627
47MP0001346_abnormal_lacrimal_gland0.77080093
48MP0001340_abnormal_eyelid_morphology0.72569664
49MP0010030_abnormal_orbit_morphology0.70453116
50MP0002877_abnormal_melanocyte_morpholog0.66017443
51MP0003315_abnormal_perineum_morphology0.65548743
52MP0001849_ear_inflammation0.64337559
53MP0000627_abnormal_mammary_gland0.61424489
54MP0001485_abnormal_pinna_reflex0.55437258
55MP0003755_abnormal_palate_morphology0.55187027
56MP0002282_abnormal_trachea_morphology0.53360686
57MP0002970_abnormal_white_adipose0.50251847
58MP0005023_abnormal_wound_healing0.48238338
59MP0001784_abnormal_fluid_regulation0.45834831
60MP0003191_abnormal_cellular_cholesterol0.45788762
61MP0002111_abnormal_tail_morphology0.42673893
62MP0001984_abnormal_olfaction0.41939508
63MP0005075_abnormal_melanosome_morpholog0.41738213
64MP0002249_abnormal_larynx_morphology0.41400198
65MP0004782_abnormal_surfactant_physiolog0.39404930
66MP0000537_abnormal_urethra_morphology0.38161378
67MP0010352_gastrointestinal_tract_polyps0.36104067
68MP0003385_abnormal_body_wall0.36005475
69MP0004272_abnormal_basement_membrane0.35710385
70MP0005451_abnormal_body_composition0.35151086
71MP0009379_abnormal_foot_pigmentation0.35044523
72MP0002177_abnormal_outer_ear0.32286720
73MP0000678_abnormal_parathyroid_gland0.31753392
74MP0002697_abnormal_eye_size0.30348602
75MP0005503_abnormal_tendon_morphology0.30266680
76MP0005248_abnormal_Harderian_gland0.30186995
77MP0005535_abnormal_body_temperature0.29052603
78MP0002163_abnormal_gland_morphology0.28007948
79MP0009780_abnormal_chondrocyte_physiolo0.27533708
80MP0009840_abnormal_foam_cell0.26467376
81MP0000432_abnormal_head_morphology0.26100426
82MP0003950_abnormal_plasma_membrane0.25918227
83MP0006054_spinal_hemorrhage0.23752623
84MP0003763_abnormal_thymus_physiology0.23186594
85MP0003935_abnormal_craniofacial_develop0.21857874
86MP0003300_gastrointestinal_ulcer0.21382344
87MP0000465_gastrointestinal_hemorrhage0.20159123
88MP0001919_abnormal_reproductive_system0.19045645
89MP0002006_tumorigenesis0.18706167
90MP0002166_altered_tumor_susceptibility0.18594201
91MP0009384_cardiac_valve_regurgitation0.18408338
92MP0000516_abnormal_urinary_system0.17004709
93MP0005367_renal/urinary_system_phenotyp0.17004709
94MP0005076_abnormal_cell_differentiation0.16960904
95MP0003329_amyloid_beta_deposits0.16753289
96MP0002009_preneoplasia0.16313358
97MP0001879_abnormal_lymphatic_vessel0.15415473
98MP0005452_abnormal_adipose_tissue0.14772117
99MP0003646_muscle_fatigue0.14252098
100MP0005375_adipose_tissue_phenotype0.13983976
101MP0000462_abnormal_digestive_system0.13785317
102MP0005666_abnormal_adipose_tissue0.13446515
103MP0004019_abnormal_vitamin_homeostasis0.13083112
104MP0004858_abnormal_nervous_system0.12948064
105MP0004742_abnormal_vestibular_system0.12784450
106MP0002233_abnormal_nose_morphology0.12114290
107MP0005379_endocrine/exocrine_gland_phen0.11505650
108MP0005193_abnormal_anterior_eye0.11439440
109MP0001905_abnormal_dopamine_level0.10892610
110MP0003448_altered_tumor_morphology0.10739304
111MP0003638_abnormal_response/metabolism_0.10531000
112MP0000013_abnormal_adipose_tissue0.10034447
113MP0005508_abnormal_skeleton_morphology0.09896301
114MP0000428_abnormal_craniofacial_morphol0.09813883
115MP0000685_abnormal_immune_system0.09789140
116MP0000733_abnormal_muscle_development0.09421956
117MP0001730_embryonic_growth_arrest0.08855245
118MP0001186_pigmentation_phenotype0.08484621
119MP0001958_emphysema0.08215130
120MP0002971_abnormal_brown_adipose0.07843521
121MP0003045_fibrosis0.07726644
122MP0000604_amyloidosis0.06728577
123MP0006138_congestive_heart_failure0.06614617
124MP0009703_decreased_birth_body0.06465171
125MP0005646_abnormal_pituitary_gland0.05804265
126MP0000358_abnormal_cell_content/0.04358350
127MP0002118_abnormal_lipid_homeostasis0.01154683
128MP0001881_abnormal_mammary_gland0.00032586
129MP0001756_abnormal_urination-0.0449126
130MP0000751_myopathy-0.0379082
131MP0002109_abnormal_limb_morphology-0.0337282
132MP0004043_abnormal_pH_regulation-0.0255265
133MP0001666_abnormal_nutrient_absorption-0.0167977

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.68518016
2Nail dystrophy (HP:0008404)7.22266252
3Abnormal hair laboratory examination (HP:0003328)6.12319431
4Abnormality of nail color (HP:0100643)5.98322628
5Absent eyebrow (HP:0002223)5.73955143
6Fragile nails (HP:0001808)5.55382408
7Fine hair (HP:0002213)5.33620032
8Absent hair (HP:0002298)5.10694802
9Follicular hyperkeratosis (HP:0007502)4.92366959
10Alopecia of scalp (HP:0002293)4.79180135
11Palmoplantar hyperkeratosis (HP:0000972)4.58008127
12Onycholysis (HP:0001806)4.50492226
13Palmar hyperkeratosis (HP:0010765)4.31150605
14Thick nail (HP:0001805)4.22520582
15Abnormality of secondary sexual hair (HP:0009888)4.21999123
16Abnormality of the axillary hair (HP:0100134)4.21999123
17Plantar hyperkeratosis (HP:0007556)4.18139803
18Right ventricular cardiomyopathy (HP:0011663)4.12177223
19Increased IgE level (HP:0003212)3.98402784
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.85483810
21Sparse eyelashes (HP:0000653)3.78146014
22Erythema (HP:0010783)3.38768814
23Milia (HP:0001056)3.32559177
24Abnormality of the frontal sinuses (HP:0002687)3.27005807
25Oral leukoplakia (HP:0002745)3.22286727
26Amelogenesis imperfecta (HP:0000705)3.22276345
27Congenital, generalized hypertrichosis (HP:0004540)3.14037818
28Parakeratosis (HP:0001036)2.97694979
29Curly hair (HP:0002212)2.71635371
30Erythroderma (HP:0001019)2.62998611
31Aplasia cutis congenita (HP:0001057)2.62309861
32Ridged nail (HP:0001807)2.60918219
33Intention tremor (HP:0002080)2.58607423
34Natal tooth (HP:0000695)2.46544318
35Neck muscle weakness (HP:0000467)2.38234041
36Torticollis (HP:0000473)2.37914596
37Hamartoma of the eye (HP:0010568)2.37166674
38Dry hair (HP:0011359)2.36022547
39Advanced eruption of teeth (HP:0006288)2.33414392
40Congenital ichthyosiform erythroderma (HP:0007431)2.29086337
41Abnormal blistering of the skin (HP:0008066)2.24807307
42Abnormality of the parietal bone (HP:0002696)2.20052727
43Craniofacial dystonia (HP:0012179)2.00499773
44Hypotrichosis (HP:0001006)14.5206041
45Woolly hair (HP:0002224)11.3842235
46Abnormality of hair growth rate (HP:0011363)11.2124851
47Slow-growing hair (HP:0002217)11.2124851
48Brittle hair (HP:0002299)10.3801657
49Corneal erosion (HP:0200020)1.97970766
50Hypohidrosis (HP:0000966)1.96292168
51Ventricular tachycardia (HP:0004756)1.92995037
52Coarse hair (HP:0002208)1.91621826
53Abnormality of the dental root (HP:0006486)1.89503689
54Taurodontia (HP:0000679)1.89503689
55Abnormality of permanent molar morphology (HP:0011071)1.89503689
56Palmoplantar keratoderma (HP:0000982)1.88314127
57Absent eyelashes (HP:0000561)1.88157238
58Pruritus (HP:0000989)1.87115560
59Concave nail (HP:0001598)1.85981631
60Abnormality of molar (HP:0011077)1.85918749
61Abnormality of molar morphology (HP:0011070)1.85918749
62Focal dystonia (HP:0004373)1.83109284
63Difficulty walking (HP:0002355)1.82851948
64Abnormality of dental color (HP:0011073)1.81829429
65Abnormality of the pupil (HP:0000615)1.80561785
66Ventricular fibrillation (HP:0001663)1.79731101
67Widely patent fontanelles and sutures (HP:0004492)1.78023858
68Abnormality of the dental pulp (HP:0006479)1.65483210
69Recurrent corneal erosions (HP:0000495)1.63665146
70Blepharitis (HP:0000498)1.63460392
71Furrowed tongue (HP:0000221)1.53344834
72Abnormality of the aortic arch (HP:0012303)1.53048240
73Lip pit (HP:0100267)1.52264251
74Hyporeflexia of lower limbs (HP:0002600)1.50639090
75Abnormality of placental membranes (HP:0011409)1.50233761
76Amniotic constriction ring (HP:0009775)1.50233761
77Abnormality of the neuromuscular junction (HP:0003398)1.49990400
78Fatigable weakness (HP:0003473)1.49990400
79Acanthosis nigricans (HP:0000956)1.47221231
80Urticaria (HP:0001025)1.45654332
81Unilateral renal agenesis (HP:0000122)1.44537702
82Carious teeth (HP:0000670)1.41759146
83Craniofacial hyperostosis (HP:0004493)1.41327796
84Heterogeneous (HP:0001425)1.39227219
85Sudden death (HP:0001699)1.37483772
86Abnormality of the salivary glands (HP:0010286)1.35458820
87Anonychia (HP:0001798)1.33751847
88Keratoconjunctivitis sicca (HP:0001097)1.33024711
89Sparse scalp hair (HP:0002209)1.32606442
90Atrophic scars (HP:0001075)1.30721904
91Selective tooth agenesis (HP:0001592)1.30146117
92Widely spaced teeth (HP:0000687)1.29725612
93Achilles tendon contracture (HP:0001771)1.28851206
94Autoamputation (HP:0001218)1.27232506
95Abnormality of the fingernails (HP:0001231)1.26278993
96Multifactorial inheritance (HP:0001426)1.24730866
97Conjunctival hamartoma (HP:0100780)1.23540848
98Ectropion (HP:0000656)1.21228360
99Distal lower limb muscle weakness (HP:0009053)1.20700521
100Abnormality of the Achilles tendon (HP:0005109)1.20579177
101Keratoconjunctivitis (HP:0001096)1.16449374
102Variable expressivity (HP:0003828)1.16065234
103Laryngomalacia (HP:0001601)1.15585197
104Hamartoma (HP:0010566)1.14506825
105Type 1 muscle fiber predominance (HP:0003803)1.14498205
106Increased connective tissue (HP:0009025)1.14094108
107Neonatal onset (HP:0003623)1.13117481
108Abnormality of the gastric mucosa (HP:0004295)1.13106324
109Hypergammaglobulinemia (HP:0010702)1.12987666
110Wide cranial sutures (HP:0010537)1.12112305
111Gangrene (HP:0100758)1.11865450
112Round ear (HP:0100830)1.10793468
113Hyperhidrosis (HP:0000975)1.10379922
114Skin ulcer (HP:0200042)1.10331195
115Aplasia involving bones of the upper limbs (HP:0009823)1.10242776
116Aplasia of the phalanges of the hand (HP:0009802)1.10242776
117Aplasia involving bones of the extremities (HP:0009825)1.10242776
118Melanocytic nevus (HP:0000995)1.09700223
119Septate vagina (HP:0001153)1.03624372
120Conical tooth (HP:0000698)1.00520529
121Split foot (HP:0001839)0.99371195
122Neonatal short-limb short stature (HP:0008921)0.93250585
123Generalized hyperpigmentation (HP:0007440)0.92283694
124Nasolacrimal duct obstruction (HP:0000579)0.92210389
125Dry skin (HP:0000958)0.91844775
126Seborrheic dermatitis (HP:0001051)0.87695024
127Dehydration (HP:0001944)0.86844105
128Papilloma (HP:0012740)0.86523032
129Verrucae (HP:0200043)0.86523032
130Neonatal death (HP:0003811)0.84516999
131Xerostomia (HP:0000217)0.84280663
132Acanthocytosis (HP:0001927)0.84093863
133Cranial hyperostosis (HP:0004437)0.83710308
134Hypoplastic toenails (HP:0001800)0.82019368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.32365433
2FER4.12159582
3MAPKAPK33.85062868
4MAP3K63.83673740
5ERN13.70970549
6EPHB23.37120018
7TAOK13.08326905
8STK242.91121183
9LATS12.85943219
10MAP3K32.77067965
11TRIB32.66038894
12MAP3K22.53121089
13MAP3K112.05775355
14STK392.04570088
15FGFR21.95250235
16RPS6KB21.93382179
17EEF2K1.83118003
18MYLK1.82667524
19MAPKAPK51.80468738
20PRPF4B1.77364019
21LATS21.66196678
22PIK3CG1.64035720
23MAPK71.59934830
24TTN1.57469132
25EPHB11.57326651
26BCR1.57317336
27MAP2K61.55956824
28LMTK21.43685527
29RIPK11.35876077
30FGFR31.30460116
31FGFR11.29482398
32CDK61.28669047
33MAP3K11.25868941
34NME11.24088757
35FGFR41.21317958
36SMG11.20650716
37BMX1.18039578
38MAP3K121.14890420
39PKN21.13295499
40KSR21.11138455
41PDGFRA1.10891581
42MAP3K71.08025266
43PTK61.07283311
44MAPKAPK21.06348274
45MST1R1.04920414
46MAP2K31.02777537
47RPS6KB10.99564135
48SIK10.97695206
49BLK0.94486345
50RPS6KA40.93803727
51PBK0.88895945
52LRRK20.88837081
53OXSR10.87650994
54MAP3K90.84838102
55MAP3K100.84296734
56PTK20.82748433
57MAP2K40.81437748
58PRKD20.78069675
59STK380.76222707
60DYRK1B0.75994041
61ILK0.73629540
62STK38L0.73302515
63PAK40.71823935
64ERBB40.71533276
65MAP2K10.70810712
66PRKD10.67105635
67MET0.66439294
68PIM20.65356378
69PINK10.65210629
70EPHA40.61858441
71PRKCI0.60946520
72ABL20.60086783
73MINK10.59797191
74ERBB20.58609324
75TRPM70.56468934
76DDR20.56370933
77TESK10.55828972
78CDK190.55618338
79PAK30.55282913
80MAP3K50.53883466
81SGK4940.52811818
82SGK2230.52811818
83PRKCH0.52254052
84TGFBR10.50987205
85PRKAA20.49086512
86NEK10.47684699
87RET0.47370710
88RPS6KA10.47309423
89JAK10.46662578
90NTRK20.46653291
91CASK0.46579298
92MAPK40.46447700
93TYRO30.46446695
94CSNK1E0.45232893
95PAK20.45107406
96IRAK10.44883979
97OBSCN0.44435189
98PDK20.42678544
99IKBKB0.42396921
100GSK3A0.42062822
101MAPK120.41533095
102PAK60.39698078
103ALK0.38064783
104NME20.37869089
105TYK20.36940365
106CDK70.36448454
107NLK0.35942692
108CDC42BPA0.35913458
109PIK3CA0.35789038
110ADRBK10.35699648
111EPHA30.35014814
112MTOR0.34280764
113NEK60.33498555
114CLK10.31955432
115STK30.31701848
116PDPK10.31492369
117MAP2K20.30947386
118JAK20.30869104
119HIPK20.30384321
120MST40.29814308
121SGK20.29421310
122FYN0.28798152
123ERBB30.28556342
124RPS6KA20.28397295
125SGK30.27496526
126STK110.27327709
127MAP3K80.26955981
128ICK0.25762771
129SGK10.25708989
130MAPK80.25291811
131KIT0.25055095
132CSNK1A10.24653439
133MARK20.24387189
134PRKACG0.24169344
135MAPK90.23748731
136SRC0.23717700
137CSNK1D0.23339859
138CSNK1A1L0.22711869
139PRKACA0.22597666
140CSNK1G10.22465229
141GRK60.20880577
142ROCK10.18279943
143PRKCE0.16968233
144CSK0.16822011

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.69991454
2Linoleic acid metabolism_Homo sapiens_hsa005914.67370457
3Vitamin digestion and absorption_Homo sapiens_hsa049774.18983306
4Fat digestion and absorption_Homo sapiens_hsa049753.05972274
5Fatty acid biosynthesis_Homo sapiens_hsa000612.96986040
6Basal cell carcinoma_Homo sapiens_hsa052172.85174099
7Fatty acid elongation_Homo sapiens_hsa000622.53405251
8Ether lipid metabolism_Homo sapiens_hsa005652.47079029
9Retinol metabolism_Homo sapiens_hsa008301.96936465
10Sphingolipid metabolism_Homo sapiens_hsa006001.92637719
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.88634255
12Hedgehog signaling pathway_Homo sapiens_hsa043401.86084537
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83443901
14Melanogenesis_Homo sapiens_hsa049161.76621768
15Arachidonic acid metabolism_Homo sapiens_hsa005901.70728436
16Phenylalanine metabolism_Homo sapiens_hsa003601.69416401
17VEGF signaling pathway_Homo sapiens_hsa043701.64581883
18Axon guidance_Homo sapiens_hsa043601.62325301
19Thyroid cancer_Homo sapiens_hsa052161.56067705
20Hippo signaling pathway_Homo sapiens_hsa043901.52936125
21Glycerolipid metabolism_Homo sapiens_hsa005611.47907580
22Bladder cancer_Homo sapiens_hsa052191.47381719
23Glioma_Homo sapiens_hsa052141.43586948
24Proteoglycans in cancer_Homo sapiens_hsa052051.42558906
25Acute myeloid leukemia_Homo sapiens_hsa052211.28833742
26Caffeine metabolism_Homo sapiens_hsa002321.28472922
27Dorso-ventral axis formation_Homo sapiens_hsa043201.26029302
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.26000346
29Histidine metabolism_Homo sapiens_hsa003401.22937113
30Mineral absorption_Homo sapiens_hsa049781.22116837
31Tight junction_Homo sapiens_hsa045301.17507518
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17461834
33Adherens junction_Homo sapiens_hsa045201.16275839
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14621240
35GnRH signaling pathway_Homo sapiens_hsa049121.14331519
36Endometrial cancer_Homo sapiens_hsa052131.10680635
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10472169
38ECM-receptor interaction_Homo sapiens_hsa045121.06570660
39Pancreatic secretion_Homo sapiens_hsa049721.04635416
40Long-term potentiation_Homo sapiens_hsa047201.03106056
41Non-small cell lung cancer_Homo sapiens_hsa052231.01243821
42Collecting duct acid secretion_Homo sapiens_hsa049661.00457124
43Wnt signaling pathway_Homo sapiens_hsa043101.00252816
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98848526
45PPAR signaling pathway_Homo sapiens_hsa033200.97364034
46Ovarian steroidogenesis_Homo sapiens_hsa049130.97077445
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95958979
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95358259
49Nitrogen metabolism_Homo sapiens_hsa009100.93849351
50Steroid biosynthesis_Homo sapiens_hsa001000.90169898
51Tyrosine metabolism_Homo sapiens_hsa003500.89431590
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.84126915
53Ras signaling pathway_Homo sapiens_hsa040140.82399386
54Long-term depression_Homo sapiens_hsa047300.82355307
55Estrogen signaling pathway_Homo sapiens_hsa049150.80906189
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.80018952
57Amoebiasis_Homo sapiens_hsa051460.79796525
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77925443
59MicroRNAs in cancer_Homo sapiens_hsa052060.76525709
60Pertussis_Homo sapiens_hsa051330.75360881
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70825832
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70584822
63Peroxisome_Homo sapiens_hsa041460.68535399
64TGF-beta signaling pathway_Homo sapiens_hsa043500.67054881
65beta-Alanine metabolism_Homo sapiens_hsa004100.66834620
66Protein digestion and absorption_Homo sapiens_hsa049740.65035609
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64799748
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63741335
69Insulin resistance_Homo sapiens_hsa049310.63293710
70Hepatitis C_Homo sapiens_hsa051600.61908374
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.61588060
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.61383314
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60733999
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.60490200
75Lysosome_Homo sapiens_hsa041420.60107554
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59997794
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59938325
78Focal adhesion_Homo sapiens_hsa045100.59689764
79Rap1 signaling pathway_Homo sapiens_hsa040150.59058440
80Gastric acid secretion_Homo sapiens_hsa049710.58332440
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57377671
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.55797007
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55617669
84Pyruvate metabolism_Homo sapiens_hsa006200.55600263
85Gap junction_Homo sapiens_hsa045400.55480464
86Renin secretion_Homo sapiens_hsa049240.55450057
87Renal cell carcinoma_Homo sapiens_hsa052110.54429789
88ErbB signaling pathway_Homo sapiens_hsa040120.53992244
89Serotonergic synapse_Homo sapiens_hsa047260.51735501
90Olfactory transduction_Homo sapiens_hsa047400.51685798
91Staphylococcus aureus infection_Homo sapiens_hsa051500.51267268
92Amphetamine addiction_Homo sapiens_hsa050310.50361010
93Salmonella infection_Homo sapiens_hsa051320.50002422
94Fatty acid metabolism_Homo sapiens_hsa012120.49400306
95Chronic myeloid leukemia_Homo sapiens_hsa052200.48605973
96Platelet activation_Homo sapiens_hsa046110.48325163
97Notch signaling pathway_Homo sapiens_hsa043300.47752905
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47512038
99Melanoma_Homo sapiens_hsa052180.47424414
100Oxytocin signaling pathway_Homo sapiens_hsa049210.45979086
101Phototransduction_Homo sapiens_hsa047440.45038137
102Pathways in cancer_Homo sapiens_hsa052000.43810250
103p53 signaling pathway_Homo sapiens_hsa041150.43759705
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43596156
105Butanoate metabolism_Homo sapiens_hsa006500.42708258
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41803630
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39343827
108Prolactin signaling pathway_Homo sapiens_hsa049170.38971474
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38967303
110Toxoplasmosis_Homo sapiens_hsa051450.38454569
111Prostate cancer_Homo sapiens_hsa052150.38325312
112Salivary secretion_Homo sapiens_hsa049700.38181725
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37558584
114Insulin signaling pathway_Homo sapiens_hsa049100.37227272
115Prion diseases_Homo sapiens_hsa050200.37044537
116Circadian entrainment_Homo sapiens_hsa047130.35326495
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34742956
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.33912629
119Tuberculosis_Homo sapiens_hsa051520.33240152
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33022693
121Glucagon signaling pathway_Homo sapiens_hsa049220.32864166
122HTLV-I infection_Homo sapiens_hsa051660.32833694
123Fatty acid degradation_Homo sapiens_hsa000710.32363681
124Endocytosis_Homo sapiens_hsa041440.32251107
125Malaria_Homo sapiens_hsa051440.29202105
126Arginine and proline metabolism_Homo sapiens_hsa003300.28410871
127Choline metabolism in cancer_Homo sapiens_hsa052310.27149008
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.26930060
129Vibrio cholerae infection_Homo sapiens_hsa051100.25041933
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.24750202
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22473018
132Arginine biosynthesis_Homo sapiens_hsa002200.21736336
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19222553
134Synaptic vesicle cycle_Homo sapiens_hsa047210.17915155
135Renin-angiotensin system_Homo sapiens_hsa046140.17859272
136Dopaminergic synapse_Homo sapiens_hsa047280.15190837
137Chemical carcinogenesis_Homo sapiens_hsa052040.15002766
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14363770
139Calcium signaling pathway_Homo sapiens_hsa040200.12350518
140Inositol phosphate metabolism_Homo sapiens_hsa005620.11205110
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.10764958
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.09872971

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