KRT26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin genes on chromosome 17q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.90957470
2axon ensheathment in central nervous system (GO:0032291)8.90957470
3fatty acid elongation (GO:0030497)7.09213365
4adhesion of symbiont to host cell (GO:0044650)6.74280409
5virion attachment to host cell (GO:0019062)6.74280409
6long-chain fatty acid biosynthetic process (GO:0042759)5.87810757
7myelination (GO:0042552)5.83499698
8ensheathment of neurons (GO:0007272)5.80868751
9axon ensheathment (GO:0008366)5.80868751
10adhesion of symbiont to host (GO:0044406)5.30122846
11glycerophospholipid catabolic process (GO:0046475)5.30039376
12sperm motility (GO:0030317)4.71338513
13negative regulation of neurotransmitter secretion (GO:0046929)4.68749235
14cholesterol biosynthetic process (GO:0006695)4.63877082
15response to pheromone (GO:0019236)4.59419650
16presynaptic membrane assembly (GO:0097105)4.49053711
17oligodendrocyte differentiation (GO:0048709)4.41839706
18regulation of sarcomere organization (GO:0060297)4.35062637
19acrosome reaction (GO:0007340)4.29916859
20presynaptic membrane organization (GO:0097090)4.27139393
21cellular ketone body metabolic process (GO:0046950)4.26332779
22behavioral response to nicotine (GO:0035095)4.18681759
23meiotic chromosome segregation (GO:0045132)4.11119759
24NAD biosynthetic process (GO:0009435)4.09441781
25negative regulation of neurotransmitter transport (GO:0051589)4.07608073
26isoprenoid biosynthetic process (GO:0008299)4.06293255
27protein polyglutamylation (GO:0018095)4.04402312
28multicellular organism reproduction (GO:0032504)4.01161906
29sterol biosynthetic process (GO:0016126)3.97244748
30regulation of female gonad development (GO:2000194)3.96828181
31fusion of sperm to egg plasma membrane (GO:0007342)3.91989148
32regulation of collateral sprouting (GO:0048670)3.87028738
33regulation of hexokinase activity (GO:1903299)3.82358571
34regulation of glucokinase activity (GO:0033131)3.82358571
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.80535078
36regulation of translation, ncRNA-mediated (GO:0045974)3.80535078
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.80535078
38ketone body metabolic process (GO:1902224)3.75219171
39response to redox state (GO:0051775)3.74449676
40positive regulation of action potential (GO:0045760)3.73689146
41neuron cell-cell adhesion (GO:0007158)3.73426426
42oxidative demethylation (GO:0070989)3.73406350
43substantia nigra development (GO:0021762)3.69455926
44kynurenine metabolic process (GO:0070189)3.69423773
45keratinization (GO:0031424)3.68390395
46indole-containing compound catabolic process (GO:0042436)3.67984371
47indolalkylamine catabolic process (GO:0046218)3.67984371
48tryptophan catabolic process (GO:0006569)3.67984371
49cell wall macromolecule metabolic process (GO:0044036)3.66428625
50exogenous drug catabolic process (GO:0042738)3.63248757
51cilium or flagellum-dependent cell motility (GO:0001539)3.62823992
52indolalkylamine metabolic process (GO:0006586)3.52128394
53import into cell (GO:0098657)3.48571948
54piRNA metabolic process (GO:0034587)3.48015036
55nucleotide transmembrane transport (GO:1901679)3.47498615
56apical protein localization (GO:0045176)3.46138011
57intermediate filament organization (GO:0045109)3.45540478
58histone H3-K9 methylation (GO:0051567)3.44464849
59peptidyl-tyrosine autophosphorylation (GO:0038083)3.41874601
60epithelial cilium movement (GO:0003351)3.40220098
61epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.39273590
62alkaloid metabolic process (GO:0009820)3.36424459
63RNA destabilization (GO:0050779)3.34839472
64DNA methylation involved in gamete generation (GO:0043046)3.34425404
65eye photoreceptor cell differentiation (GO:0001754)3.34095265
66photoreceptor cell differentiation (GO:0046530)3.34095265
67detection of light stimulus involved in visual perception (GO:0050908)3.31722073
68detection of light stimulus involved in sensory perception (GO:0050962)3.31722073
69reflex (GO:0060004)3.30946169
70cell wall macromolecule catabolic process (GO:0016998)3.30583935
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29242718
72cerebral cortex radially oriented cell migration (GO:0021799)3.28899115
73astrocyte development (GO:0014002)3.28735668
74calcium ion-dependent exocytosis (GO:0017156)3.28148000
75transmission of nerve impulse (GO:0019226)3.27484627
76asymmetric protein localization (GO:0008105)3.25598254
77negative regulation of protein localization to cell surface (GO:2000009)3.25560091
78drug catabolic process (GO:0042737)3.24487161
79limb bud formation (GO:0060174)3.23202538
80creatine metabolic process (GO:0006600)3.22000344
81regulation of cilium movement (GO:0003352)3.18688269
82amyloid precursor protein metabolic process (GO:0042982)3.17934362
83spermatid development (GO:0007286)3.17315506
84myelin maintenance (GO:0043217)3.17173994
85negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.14800195
86L-amino acid import (GO:0043092)3.13043400
87pyridine nucleotide biosynthetic process (GO:0019363)3.10949256
88nicotinamide nucleotide biosynthetic process (GO:0019359)3.10949256
89plasma membrane fusion (GO:0045026)3.10838969
90dendritic spine morphogenesis (GO:0060997)3.07307257
91cilium movement (GO:0003341)3.06083535
92membrane depolarization during action potential (GO:0086010)3.04483389
93tryptophan metabolic process (GO:0006568)3.04289777
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.03513327
95intermediate filament-based process (GO:0045103)3.02708936
96negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.01272533
97long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.00928804
98lateral sprouting from an epithelium (GO:0060601)3.00846817
99protein palmitoylation (GO:0018345)2.97899712
100GPI anchor biosynthetic process (GO:0006506)2.96781958
101long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.96066937
102response to lipoprotein particle (GO:0055094)2.94167861
103phosphatidylserine acyl-chain remodeling (GO:0036150)2.94128136
104cAMP catabolic process (GO:0006198)2.93588801
105establishment of protein localization to Golgi (GO:0072600)2.92842357
106sperm-egg recognition (GO:0035036)2.91963969
107amyloid precursor protein catabolic process (GO:0042987)2.91805548
108myelination in peripheral nervous system (GO:0022011)2.91430255
109peripheral nervous system axon ensheathment (GO:0032292)2.91430255
110regulation of action potential (GO:0098900)2.90933315
111DNA deamination (GO:0045006)2.88142430
112primary amino compound metabolic process (GO:1901160)2.87652654
113monoubiquitinated protein deubiquitination (GO:0035520)2.87202780
114positive regulation of actin filament depolymerization (GO:0030836)2.86584661
115cellular response to epinephrine stimulus (GO:0071872)2.84606721
116negative regulation of JUN kinase activity (GO:0043508)2.83508447
117protein localization to cilium (GO:0061512)2.83011961
118leukocyte migration involved in inflammatory response (GO:0002523)2.82480456
119regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80689862
120organic cation transport (GO:0015695)2.80626091
121reproduction (GO:0000003)2.80375043
122GPI anchor metabolic process (GO:0006505)2.80036590
123opioid receptor signaling pathway (GO:0038003)2.79994482
124histone H2A monoubiquitination (GO:0035518)2.79185308
125membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.79075110
126indole-containing compound metabolic process (GO:0042430)2.79034421
127intermediate filament cytoskeleton organization (GO:0045104)2.78401804
128negative regulation of axonogenesis (GO:0050771)2.76740230
129citrulline biosynthetic process (GO:0019240)2.76181500
130neural tube formation (GO:0001841)2.76052997
131peptidyl-threonine dephosphorylation (GO:0035970)2.75627582
132ear development (GO:0043583)2.74333767
133hair follicle morphogenesis (GO:0031069)2.73773499
134negative regulation of myoblast differentiation (GO:0045662)2.73753924
135positive regulation of oligodendrocyte differentiation (GO:0048714)2.73557581
136histone H3-K9 modification (GO:0061647)2.72831535
137activated T cell proliferation (GO:0050798)2.71485744
138L-fucose catabolic process (GO:0042355)2.70775388
139fucose catabolic process (GO:0019317)2.70775388
140L-fucose metabolic process (GO:0042354)2.70775388
141magnesium ion transport (GO:0015693)2.70344385
142hydrogen peroxide biosynthetic process (GO:0050665)2.69020258
143negative regulation of axon extension (GO:0030517)2.68922166
144neuronal ion channel clustering (GO:0045161)2.68853008
145behavioral response to ethanol (GO:0048149)2.68838306
146neuronal action potential (GO:0019228)2.67839852
147centriole replication (GO:0007099)2.66964401
148membrane assembly (GO:0071709)2.66468308
149omega-hydroxylase P450 pathway (GO:0097267)2.65582907
150negative regulation of systemic arterial blood pressure (GO:0003085)2.65217635
151cellular biogenic amine catabolic process (GO:0042402)2.64059614
152amine catabolic process (GO:0009310)2.64059614
153neural nucleus development (GO:0048857)2.63223878
154positive regulation of Rab GTPase activity (GO:0032851)2.63110346
155regulation of Rab GTPase activity (GO:0032313)2.63110346
156response to epinephrine (GO:0071871)2.62237834
157positive regulation of meiotic cell cycle (GO:0051446)2.59271230
158cell proliferation in forebrain (GO:0021846)2.58979371
159axonemal dynein complex assembly (GO:0070286)2.58765140
160establishment of mitochondrion localization (GO:0051654)2.58356184
161gamma-aminobutyric acid transport (GO:0015812)2.58067621
162left/right axis specification (GO:0070986)2.56765068
163detection of mechanical stimulus involved in sensory perception (GO:0050974)2.56452238
164histone H2A ubiquitination (GO:0033522)2.56337907
165phosphatidylserine metabolic process (GO:0006658)2.56311591
166single strand break repair (GO:0000012)2.54024334
167preassembly of GPI anchor in ER membrane (GO:0016254)2.53987214
168serotonin metabolic process (GO:0042428)2.53779571
169synaptic transmission, cholinergic (GO:0007271)2.53033064
170microtubule severing (GO:0051013)2.52991606
171phosphatidylethanolamine biosynthetic process (GO:0006646)2.52089754
172glial cell development (GO:0021782)2.51913163
173adult walking behavior (GO:0007628)2.51495226
174positive regulation of cellular amine metabolic process (GO:0033240)2.51476963
175cyclic nucleotide catabolic process (GO:0009214)2.51002537
176protein neddylation (GO:0045116)2.50998717
177protein K63-linked deubiquitination (GO:0070536)2.50889903
178signal peptide processing (GO:0006465)2.50886574
179very long-chain fatty acid metabolic process (GO:0000038)2.49274482
180peripheral nervous system development (GO:0007422)2.48861172
181neuron remodeling (GO:0016322)2.46729401
182positive regulation of interleukin-17 production (GO:0032740)2.45747130
183fatty-acyl-CoA biosynthetic process (GO:0046949)2.44718118
184mannosylation (GO:0097502)2.41944355
185cerebellar granule cell differentiation (GO:0021707)2.40629462
186neurotransmitter catabolic process (GO:0042135)2.38057219
187keratinocyte development (GO:0003334)2.37872407
188fatty-acyl-CoA metabolic process (GO:0035337)2.37055897
189organ growth (GO:0035265)2.36884861
190regulation of feeding behavior (GO:0060259)2.36328042
191amino acid import (GO:0043090)2.35100913
192peptide cross-linking (GO:0018149)2.33501065
193Rap protein signal transduction (GO:0032486)2.33474091
194mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.33064443
195gamma-aminobutyric acid signaling pathway (GO:0007214)2.32868685
196hair cycle (GO:0042633)10.1706509
197molting cycle (GO:0042303)10.1706509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.51474877
2ZNF274_21170338_ChIP-Seq_K562_Hela2.54569329
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30818237
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.27336931
5TAF15_26573619_Chip-Seq_HEK293_Human2.25376641
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23831539
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20387882
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18971946
9SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.13083240
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05179863
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.04657526
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02990740
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96497656
14POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.95937063
15TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95937063
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94266622
17VDR_22108803_ChIP-Seq_LS180_Human1.93950554
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92816704
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88520855
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88520855
21* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87275426
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.85963148
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85154165
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84519660
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83247205
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.82314150
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81253874
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80833900
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80824271
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77404168
31ER_23166858_ChIP-Seq_MCF-7_Human1.74543092
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74519052
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73023291
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72080330
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71253446
36EZH2_22144423_ChIP-Seq_EOC_Human1.70738796
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69430203
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69301903
39AR_21572438_ChIP-Seq_LNCaP_Human1.67962276
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.67647296
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67263274
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65749276
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62098616
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.58980104
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.58962657
46P300_19829295_ChIP-Seq_ESCs_Human1.56918635
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56703042
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54352138
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51762897
50CBP_20019798_ChIP-Seq_JUKART_Human1.51762897
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49315854
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48929819
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.48264683
54TCF4_23295773_ChIP-Seq_U87_Human1.45258047
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44410603
56RNF2_27304074_Chip-Seq_NSC_Mouse1.43334912
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42156065
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41623566
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39458674
60AR_25329375_ChIP-Seq_VCAP_Human1.39248378
61IGF1R_20145208_ChIP-Seq_DFB_Human1.36278941
62FUS_26573619_Chip-Seq_HEK293_Human1.36131507
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35040960
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34128550
65DROSHA_22980978_ChIP-Seq_HELA_Human1.33289639
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32170863
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.31553147
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.30808371
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.29869378
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29340633
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.29103754
72SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27964921
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26091312
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.26070196
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24710462
76BCAT_22108803_ChIP-Seq_LS180_Human1.24159846
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22751963
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22397883
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21841212
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21767337
81P300_18555785_Chip-Seq_ESCs_Mouse1.20809087
82TP53_18474530_ChIP-ChIP_U2OS_Human1.20055014
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19749424
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19504287
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18457813
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.18165815
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17770020
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17549049
89RUNX2_22187159_ChIP-Seq_PCA_Human1.16725768
90SMAD4_21799915_ChIP-Seq_A2780_Human1.15274353
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14745952
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14685264
93P53_22387025_ChIP-Seq_ESCs_Mouse1.14417354
94OCT4_20526341_ChIP-Seq_ESCs_Human1.12552734
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.11790791
96TAF2_19829295_ChIP-Seq_ESCs_Human1.11448841
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10960872
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.10960872
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10875963
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.10869207
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.10863867
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10832961
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10323338
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09416253
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.08567340
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08424578
107LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07709610
108TCF4_22108803_ChIP-Seq_LS180_Human1.07360704
109TP63_17297297_ChIP-ChIP_HaCaT_Human1.06866602
110SOX2_18555785_Chip-Seq_ESCs_Mouse1.06374206
111STAT3_18555785_Chip-Seq_ESCs_Mouse1.05546808
112SMAD3_21741376_ChIP-Seq_ESCs_Human1.05308192
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05232398
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05193464
115RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05026203
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.04867864
117SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04644586
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.04316637
119TP53_22573176_ChIP-Seq_HFKS_Human1.03416582
120SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03099139
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.02150801
122REST_18959480_ChIP-ChIP_MESCs_Mouse1.01985444
123ERA_21632823_ChIP-Seq_H3396_Human1.01730264
124REST_21632747_ChIP-Seq_MESCs_Mouse1.00916630
125AHR_22903824_ChIP-Seq_MCF-7_Human0.99827865
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99593952
127NANOG_20526341_ChIP-Seq_ESCs_Human0.99459691
128NMYC_18555785_Chip-Seq_ESCs_Mouse0.99329473
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98871498
130TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98658868
131SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98529839
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98158189
133ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98122217
134STAT3_23295773_ChIP-Seq_U87_Human0.98122117
135KDM2B_26808549_Chip-Seq_REH_Human0.97459639
136SOX2_19829295_ChIP-Seq_ESCs_Human0.97459577
137NANOG_19829295_ChIP-Seq_ESCs_Human0.97459577
138OCT4_18555785_Chip-Seq_ESCs_Mouse0.96250652
139OCT1_27270436_Chip-Seq_PROSTATE_Human0.96238853
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.95282079
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94971390
142FOXH1_21741376_ChIP-Seq_EPCs_Human0.94963128
143MYC_19829295_ChIP-Seq_ESCs_Human0.94746976
144FLI1_21867929_ChIP-Seq_TH2_Mouse0.94633954
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94351445
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94135157
147EWS_26573619_Chip-Seq_HEK293_Human0.94040976
148FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93778273
149P53_21459846_ChIP-Seq_SAOS-2_Human0.93426987
150HTT_18923047_ChIP-ChIP_STHdh_Human0.93071915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.13201759
2MP0003880_abnormal_central_pattern4.07332585
3MP0000579_abnormal_nail_morphology4.03079226
4MP0000383_abnormal_hair_follicle3.73870546
5MP0000647_abnormal_sebaceous_gland3.55988291
6MP0002098_abnormal_vibrissa_morphology3.31053027
7MP0000569_abnormal_digit_pigmentation3.26926888
8MP0005409_darkened_coat_color3.22711340
9MP0003787_abnormal_imprinting3.07686126
10MP0010678_abnormal_skin_adnexa3.06594966
11MP0004381_abnormal_hair_follicle2.95979104
12MP0005171_absent_coat_pigmentation2.89592691
13MP0000566_synostosis2.81455491
14MP0003136_yellow_coat_color2.80667490
15MP0001501_abnormal_sleep_pattern2.71813821
16MP0005377_hearing/vestibular/ear_phenot2.69009259
17MP0003878_abnormal_ear_physiology2.69009259
18MP0003646_muscle_fatigue2.67868641
19MP0004742_abnormal_vestibular_system2.67141964
20MP0008877_abnormal_DNA_methylation2.61106645
21MP0006292_abnormal_olfactory_placode2.60364655
22MP0003950_abnormal_plasma_membrane2.46294467
23MP0004270_analgesia2.41481245
24MP0003690_abnormal_glial_cell2.35814114
25MP0001529_abnormal_vocalization2.33175562
26MP0002796_impaired_skin_barrier2.26611157
27MP0001346_abnormal_lacrimal_gland2.14911747
28MP0008872_abnormal_physiological_respon2.14563268
29MP0001486_abnormal_startle_reflex2.11515340
30MP0001905_abnormal_dopamine_level2.05231217
31MP0004885_abnormal_endolymph2.05090861
32MP0000427_abnormal_hair_cycle1.99835413
33MP0005670_abnormal_white_adipose1.95020808
34MP0003195_calcinosis1.93228529
35MP0005646_abnormal_pituitary_gland1.91278271
36MP0002272_abnormal_nervous_system1.88053971
37MP0004133_heterotaxia1.87636507
38MP0000778_abnormal_nervous_system1.85737495
39MP0001485_abnormal_pinna_reflex1.83694195
40MP0003698_abnormal_male_reproductive1.78533661
41MP0000377_abnormal_hair_follicle1.76334916
42MP0002064_seizures1.69345717
43MP0005451_abnormal_body_composition1.63796409
44MP0008875_abnormal_xenobiotic_pharmacok1.62873118
45MP0004147_increased_porphyrin_level1.59517158
46MP0002557_abnormal_social/conspecific_i1.57216379
47MP0002822_catalepsy1.55838892
48MP0003634_abnormal_glial_cell1.53727736
49MP0002928_abnormal_bile_duct1.51375467
50MP0009745_abnormal_behavioral_response1.44184250
51MP0001929_abnormal_gametogenesis1.43930925
52MP0004142_abnormal_muscle_tone1.42991713
53MP0001661_extended_life_span1.41625711
54MP0005275_abnormal_skin_tensile1.35957544
55MP0002734_abnormal_mechanical_nocicepti1.35821874
56MP0000762_abnormal_tongue_morphology1.35443559
57MP0009046_muscle_twitch1.33012330
58MP0001188_hyperpigmentation1.30572770
59MP0000462_abnormal_digestive_system1.30068861
60MP0000631_abnormal_neuroendocrine_gland1.29393303
61MP0005423_abnormal_somatic_nervous1.28291365
62MP0001348_abnormal_lacrimal_gland1.28274515
63MP0003329_amyloid_beta_deposits1.25927665
64MP0004859_abnormal_synaptic_plasticity1.25024532
65MP0003632_abnormal_nervous_system1.24752308
66MP0005551_abnormal_eye_electrophysiolog1.24077828
67MP0002229_neurodegeneration1.22722488
68MP0005501_abnormal_skin_physiology1.21961751
69MP0002210_abnormal_sex_determination1.20142872
70MP0003121_genomic_imprinting1.18379460
71MP0001963_abnormal_hearing_physiology1.16013140
72MP0003011_delayed_dark_adaptation1.15707396
73MP0004134_abnormal_chest_morphology1.15429907
74MP0003635_abnormal_synaptic_transmissio1.13929570
75MP0004145_abnormal_muscle_electrophysio1.12777150
76MP0005174_abnormal_tail_pigmentation1.12547913
77MP0003879_abnormal_hair_cell1.12332173
78MP0002876_abnormal_thyroid_physiology1.12048089
79MP0001440_abnormal_grooming_behavior1.09916148
80MP0000467_abnormal_esophagus_morphology1.08773810
81MP0009053_abnormal_anal_canal1.08726095
82MP0003938_abnormal_ear_development1.07655544
83MP0002572_abnormal_emotion/affect_behav1.07572284
84MP0002653_abnormal_ependyma_morphology1.07133711
85MP0010771_integument_phenotype1.07130906
86MP0000026_abnormal_inner_ear1.06650532
87MP0002234_abnormal_pharynx_morphology1.05381218
88MP0008789_abnormal_olfactory_epithelium1.04422223
89MP0001851_eye_inflammation1.04003541
90MP0003718_maternal_effect1.03477025
91MP0002882_abnormal_neuron_morphology1.02752266
92MP0003283_abnormal_digestive_organ1.02600818
93MP0000653_abnormal_sex_gland1.02545195
94MP0000372_irregular_coat_pigmentation1.00951032
95MP0000955_abnormal_spinal_cord0.97086549
96MP0002735_abnormal_chemical_nociception0.96966989
97MP0002752_abnormal_somatic_nervous0.96662099
98MP0002938_white_spotting0.96261780
99MP0005647_abnormal_sex_gland0.94722979
100MP0002102_abnormal_ear_morphology0.93774296
101MP0001145_abnormal_male_reproductive0.92800994
102MP0005645_abnormal_hypothalamus_physiol0.90645132
103MP0005410_abnormal_fertilization0.90474382
104MP0005379_endocrine/exocrine_gland_phen0.90220140
105MP0001984_abnormal_olfaction0.90155265
106MP0005671_abnormal_response_to0.89825818
107MP0001243_abnormal_dermal_layer0.89802210
108MP0002067_abnormal_sensory_capabilities0.89439384
109MP0003937_abnormal_limbs/digits/tail_de0.88980493
110MP0005167_abnormal_blood-brain_barrier0.88835001
111MP0004782_abnormal_surfactant_physiolog0.88757139
112MP0001299_abnormal_eye_distance/0.86808030
113MP0001216_abnormal_epidermal_layer0.86497657
114MP0006072_abnormal_retinal_apoptosis0.85327248
115MP0004043_abnormal_pH_regulation0.85077521
116MP0000470_abnormal_stomach_morphology0.84718187
117MP0002638_abnormal_pupillary_reflex0.83528801
118MP0002066_abnormal_motor_capabilities/c0.83333116
119MP0001970_abnormal_pain_threshold0.83107437
120MP0008961_abnormal_basal_metabolism0.80521440
121MP0008569_lethality_at_weaning0.80455584
122MP0002736_abnormal_nociception_after0.79901680
123MP0004130_abnormal_muscle_cell0.79394550
124MP0003453_abnormal_keratinocyte_physiol0.79109693
125MP0005195_abnormal_posterior_eye0.78174874
126MP0001968_abnormal_touch/_nociception0.76952967
127MP0000230_abnormal_systemic_arterial0.76617393
128MP0005394_taste/olfaction_phenotype0.75803284
129MP0005499_abnormal_olfactory_system0.75803284
130MP0008260_abnormal_autophagy0.75694536
131MP0002063_abnormal_learning/memory/cond0.75019268
132MP0001765_abnormal_ion_homeostasis0.74868540
133MP0002733_abnormal_thermal_nociception0.74182281
134MP0005448_abnormal_energy_balance0.73869569
135MP0006276_abnormal_autonomic_nervous0.72341942
136MP0009250_abnormal_appendicular_skeleto0.71856280
137MP0002161_abnormal_fertility/fecundity0.71361719
138MP0004924_abnormal_behavior0.70778911
139MP0005386_behavior/neurological_phenoty0.70778911
140MP0000367_abnormal_coat/_hair0.69709874
141MP0001986_abnormal_taste_sensitivity0.68309878
142MP0009764_decreased_sensitivity_to0.68288895
143MP0002277_abnormal_respiratory_mucosa0.68115579
144MP0002184_abnormal_innervation0.68000047
145MP0005408_hypopigmentation0.66365499
146MP0000534_abnormal_ureter_morphology0.65719324
147MP0003631_nervous_system_phenotype0.64940675
148MP0001340_abnormal_eyelid_morphology0.64840371
149MP0004085_abnormal_heartbeat0.64794677
150MP0005075_abnormal_melanosome_morpholog0.63501853
151MP0005253_abnormal_eye_physiology0.63391096
152MP0005310_abnormal_salivary_gland0.61940834
153MP0002295_abnormal_pulmonary_circulatio0.61762346
154MP0001727_abnormal_embryo_implantation0.61040013
155MP0000015_abnormal_ear_pigmentation0.60378915
156MP0005623_abnormal_meninges_morphology0.60163586

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)6.92304740
2Hypotrichosis (HP:0001006)5.58015830
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.72996551
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.72996551
5Sensory axonal neuropathy (HP:0003390)4.53818197
6Genetic anticipation (HP:0003743)4.41405214
7Brittle hair (HP:0002299)4.28999765
8Neurofibrillary tangles (HP:0002185)4.25109182
9Abnormality of hair growth rate (HP:0011363)4.22313242
10Slow-growing hair (HP:0002217)4.22313242
11Pancreatic cysts (HP:0001737)4.04553204
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.01984072
13Pancreatic fibrosis (HP:0100732)3.97274654
14Woolly hair (HP:0002224)3.74861947
15Progressive cerebellar ataxia (HP:0002073)3.71429238
16Congenital ichthyosiform erythroderma (HP:0007431)3.61423232
17Abnormality of macular pigmentation (HP:0008002)3.53791527
18Congenital stationary night blindness (HP:0007642)3.51706784
19Type II lissencephaly (HP:0007260)3.49672216
20Intention tremor (HP:0002080)3.41487485
21Decreased central vision (HP:0007663)3.38911211
22Attenuation of retinal blood vessels (HP:0007843)3.37414620
23Severe visual impairment (HP:0001141)3.35041034
24Pili torti (HP:0003777)3.34721703
25Chronic hepatic failure (HP:0100626)3.34593488
26Abnormality of the corticospinal tract (HP:0002492)3.28512516
27True hermaphroditism (HP:0010459)3.28136318
28Thick nail (HP:0001805)3.26848210
29Erythroderma (HP:0001019)3.24759912
30Central scotoma (HP:0000603)3.24438765
31Abnormal rod and cone electroretinograms (HP:0008323)3.23561814
32Hypoplastic ischia (HP:0003175)3.19593660
33Nephronophthisis (HP:0000090)3.16503907
34Abnormality of the renal cortex (HP:0011035)3.15940228
35Febrile seizures (HP:0002373)3.14670641
36Follicular hyperkeratosis (HP:0007502)3.12540893
37Abnormality of the renal medulla (HP:0100957)3.04050296
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.01658527
39Retinal dysplasia (HP:0007973)3.01040996
40Hyperventilation (HP:0002883)2.99898917
41Peripheral hypomyelination (HP:0007182)2.99206836
42Polydipsia (HP:0001959)2.98886198
43Abnormal drinking behavior (HP:0030082)2.98886198
44Sclerocornea (HP:0000647)2.94838933
45Dyschromatopsia (HP:0007641)2.93533108
46Cystic liver disease (HP:0006706)2.93386507
47White forelock (HP:0002211)2.88655138
48Molar tooth sign on MRI (HP:0002419)2.85787766
49Abnormality of midbrain morphology (HP:0002418)2.85787766
50Gaze-evoked nystagmus (HP:0000640)2.83435206
51Akinesia (HP:0002304)2.79422472
52Patchy hypopigmentation of hair (HP:0011365)2.76737294
53Cerebral hypomyelination (HP:0006808)2.75723509
54Abnormal ciliary motility (HP:0012262)2.68051829
55Alacrima (HP:0000522)2.68024242
56Autoamputation (HP:0001218)2.66572293
57Cerebral inclusion bodies (HP:0100314)2.63344012
58Facial shape deformation (HP:0011334)2.62433646
59Potter facies (HP:0002009)2.62433646
60Tubular atrophy (HP:0000092)2.60949700
61Abnormality of the ischium (HP:0003174)2.60811778
62Abnormal respiratory motile cilium morphology (HP:0005938)2.59054636
63Abnormal respiratory epithelium morphology (HP:0012253)2.59054636
64Congenital, generalized hypertrichosis (HP:0004540)2.57253048
65Cerebellar dysplasia (HP:0007033)2.56578531
66Hypoplastic pelvis (HP:0008839)2.55140224
67Cupped ear (HP:0000378)2.52577291
68Absent septum pellucidum (HP:0001331)2.51940323
69Increased corneal curvature (HP:0100692)2.51361117
70Keratoconus (HP:0000563)2.51361117
71Nail dystrophy (HP:0008404)2.48317759
72Bony spicule pigmentary retinopathy (HP:0007737)2.42983595
73Recurrent corneal erosions (HP:0000495)2.41318260
74Diplopia (HP:0000651)2.40706819
75Abnormality of binocular vision (HP:0011514)2.40706819
76Onion bulb formation (HP:0003383)2.38512419
77Decreased circulating renin level (HP:0003351)2.37554833
78Scotoma (HP:0000575)2.36601792
79Split foot (HP:0001839)2.35907170
80Thickened helices (HP:0000391)2.35222045
81Conical tooth (HP:0000698)2.30922564
82Renal dysplasia (HP:0000110)2.30867174
83Polyuria (HP:0000103)2.30498415
84Bile duct proliferation (HP:0001408)2.30396440
85Abnormal biliary tract physiology (HP:0012439)2.30396440
86Bulbous nose (HP:0000414)2.29745031
87Abnormality of the pubic bones (HP:0003172)2.29460044
88Decreased lacrimation (HP:0000633)2.28296015
89Abnormality of incisor morphology (HP:0011063)2.27575213
90Renal Fanconi syndrome (HP:0001994)2.24508496
91Congenital hepatic fibrosis (HP:0002612)2.22656673
92Abnormality of the septum pellucidum (HP:0007375)2.21564877
93Septo-optic dysplasia (HP:0100842)2.20771898
94Epileptic encephalopathy (HP:0200134)2.19728226
95Abnormal auditory evoked potentials (HP:0006958)2.17208640
96Supernumerary spleens (HP:0009799)2.16589121
97Slow saccadic eye movements (HP:0000514)2.16573166
98Postural instability (HP:0002172)2.16452643
99Hyperkalemia (HP:0002153)2.16280050
100Optic nerve hypoplasia (HP:0000609)2.15048443
101Adrenal hypoplasia (HP:0000835)2.14955967
102Fine hair (HP:0002213)2.14506309
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13811013
104Abnormality of the phalanges of the 2nd finger (HP:0009541)2.13454376
105Anteriorly placed anus (HP:0001545)2.12914568
106Pendular nystagmus (HP:0012043)2.12633425
107Dysmetria (HP:0001310)2.12503132
108Synostosis involving the elbow (HP:0003938)2.12203651
109Humeroradial synostosis (HP:0003041)2.12203651
110Leukodystrophy (HP:0002415)2.11518119
111Aplasia involving bones of the upper limbs (HP:0009823)2.11454278
112Aplasia of the phalanges of the hand (HP:0009802)2.11454278
113Aplasia involving bones of the extremities (HP:0009825)2.11454278
114Abnormality of nail color (HP:0100643)2.11097930
115Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10947105
116Corneal erosion (HP:0200020)2.09656077
117Constricted visual fields (HP:0001133)2.09330412
118Widely spaced teeth (HP:0000687)2.08950369
119Abnormal respiratory motile cilium physiology (HP:0012261)2.08014872
120Spastic gait (HP:0002064)2.06969389
121Erythema (HP:0010783)2.05600706
122Supranuclear gaze palsy (HP:0000605)2.05372149
123Abnormal hair laboratory examination (HP:0003328)2.05124332
124Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04618002
125Abnormality of molar morphology (HP:0011070)2.03674231
126Abnormality of molar (HP:0011077)2.03674231
127Abnormal urine output (HP:0012590)2.03411486
128Aplasia/Hypoplasia of the spleen (HP:0010451)2.02808039
129Agitation (HP:0000713)2.02721482
130Protruding tongue (HP:0010808)2.02221485
131Macular degeneration (HP:0000608)2.01665546
132Lissencephaly (HP:0001339)2.00193395
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.99519793
134Chorioretinal atrophy (HP:0000533)1.99479307
135Asplenia (HP:0001746)1.98427162
136Focal motor seizures (HP:0011153)1.97682460
137Abnormality of the dental root (HP:0006486)1.97010774
138Taurodontia (HP:0000679)1.97010774
139Abnormality of permanent molar morphology (HP:0011071)1.97010774
140Enlarged kidneys (HP:0000105)1.96857698
141Anomalous pulmonary venous return (HP:0010772)1.95904299
142Hepatosplenomegaly (HP:0001433)1.93865020
143Coronal craniosynostosis (HP:0004440)1.93734213
144Anencephaly (HP:0002323)1.93524113
145Aplasia cutis congenita (HP:0001057)1.93189382
146Nasolacrimal duct obstruction (HP:0000579)1.93021014
147Renal cortical cysts (HP:0000803)1.93019841
148Atonic seizures (HP:0010819)1.92886712
149Prolonged neonatal jaundice (HP:0006579)1.92177607
150Autoimmune thrombocytopenia (HP:0001973)1.91603388
151Small epiphyses (HP:0010585)1.91551455
152Fragile nails (HP:0001808)1.91075378
153Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90998100
154Increased serum pyruvate (HP:0003542)1.89986765
155Abnormality of glycolysis (HP:0004366)1.89986765
156Amelogenesis imperfecta (HP:0000705)1.87635693
157Oligodactyly (hands) (HP:0001180)1.86911922
158Dialeptic seizures (HP:0011146)1.86367045
159Vaginal atresia (HP:0000148)1.86152451
160Absent/shortened dynein arms (HP:0200106)1.85612749
161Dynein arm defect of respiratory motile cilia (HP:0012255)1.85612749
162Occipital encephalocele (HP:0002085)1.85232342
163Alopecia of scalp (HP:0002293)1.84521506
164Abnormality of the parietal bone (HP:0002696)1.84104376
165Clumsiness (HP:0002312)1.83285051
166Impulsivity (HP:0100710)1.82181775
167Enlarged epiphyses (HP:0010580)1.81955705
168Abnormality of the pons (HP:0007361)1.81003428
169Azoospermia (HP:0000027)1.80120744
170Furrowed tongue (HP:0000221)1.79950022
171Abnormality of renal excretion (HP:0011036)1.79328573
172Onycholysis (HP:0001806)1.79214490
173Increased neuronal autofluorescent lipopigment (HP:0002074)1.78660213
174Barrel-shaped chest (HP:0001552)1.78222364
175Amniotic constriction ring (HP:0009775)1.77925722
176Abnormality of placental membranes (HP:0011409)1.77925722
177Congenital sensorineural hearing impairment (HP:0008527)1.77885527
178Abnormality of the diencephalon (HP:0010662)1.77877978
179Inability to walk (HP:0002540)1.76106218
180Hypoplasia of the iris (HP:0007676)1.75792781
1813-Methylglutaconic aciduria (HP:0003535)1.74683479
182Medial flaring of the eyebrow (HP:0010747)1.74621427
183Abnormality of the dental pulp (HP:0006479)1.74447389
184Stridor (HP:0010307)1.74341632
185Genital tract atresia (HP:0001827)1.74293254
186Male pseudohermaphroditism (HP:0000037)1.74161548
187Corneal dystrophy (HP:0001131)1.73139134
188Hypomagnesemia (HP:0002917)1.72330211
189Increased hepatocellular lipid droplets (HP:0006565)1.71304280
190Abolished electroretinogram (ERG) (HP:0000550)1.71212935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.75101840
2STK395.82205279
3OXSR14.25142277
4TNIK3.75551738
5BCR3.47205472
6TAOK32.95827663
7CASK2.77645480
8EPHB12.62006132
9MAP4K22.58155155
10PINK12.55268231
11PBK2.53159791
12PKN12.32276832
13ACVR1B2.29429062
14CDK192.28937996
15WNK42.18019304
16NEK62.13230442
17SIK22.01088194
18DAPK21.89085519
19FGFR21.86215169
20CSNK1A1L1.80483928
21CSNK1G31.79548704
22WNK11.71208991
23MET1.68210960
24MST41.63107076
25STK38L1.62682121
26EPHA41.58053032
27STK381.57712828
28CLK11.54558439
29MAPKAPK51.51083509
30LIMK11.50808316
31UHMK11.50636246
32ADRBK11.50237006
33ZAK1.48206227
34IRAK21.45921333
35CSNK1G11.39095095
36PRPF4B1.38247947
37WNK31.35481730
38FGR1.31081207
39CSNK1G21.26754095
40TNK21.24867503
41TIE11.21454981
42CAMK2B1.20472705
43PLK41.18578876
44ROCK21.14356898
45MUSK1.12981219
46LATS11.09246614
47ERBB41.06567549
48CAMK2D1.05246404
49BMPR1B1.03788633
50CAMK1G0.99725336
51MAP2K20.98690782
52MAPK130.96395679
53MARK10.95416538
54ICK0.95113892
55DDR20.94483650
56KIT0.94482460
57IRAK40.90472147
58BRSK20.88716664
59ADRBK20.88485563
60MAP3K40.87723501
61MAPK150.87577053
62MAP2K60.87076084
63PRKCG0.86924359
64DYRK20.86883842
65SGK4940.86547948
66SGK2230.86547948
67CHUK0.83823750
68PRKCH0.83688351
69TRPM70.83627769
70SIK30.82008966
71STK160.81523203
72PRKCQ0.81269968
73PNCK0.80875819
74IRAK10.78236126
75BMPR20.78143443
76PRKCE0.77800279
77CAMK2A0.74623219
78ABL20.74503744
79MATK0.73853873
80CAMK2G0.73313096
81GRK70.69499895
82NTRK10.67610939
83GRK10.67595561
84NME10.66696878
85MAP3K110.66509217
86PRKAA20.65713700
87PTK2B0.63691450
88MAP2K70.62563410
89PAK30.62454685
90EPHA20.61150915
91STK110.59422128
92RPS6KA60.57486439
93CDK50.57391217
94CDK140.57079364
95ARAF0.56723971
96TGFBR10.56343677
97RPS6KA50.54223934
98CAMK10.53993806
99CDK30.53859188
100MARK20.53509232
101TEC0.52888192
102PRKG10.52569184
103FYN0.50384289
104PRKD20.49424669
105CSNK1A10.48896075
106EPHB20.48461930
107ERBB20.47979688
108CSNK1D0.46563968
109PAK60.46123851
110SGK20.45989868
111FES0.45955051
112CAMK1D0.44629071
113CDK150.44580007
114MKNK10.44468718
115CDK180.44285794
116TLK10.43682122
117PRKCZ0.43550530
118MAP3K60.43006318
119NUAK10.42863279
120VRK10.42843155
121NTRK30.42234816
122TRIM280.41314248
123YES10.40908492
124PRKCA0.40811421
125TYRO30.40617696
126MAPKAPK30.39524621
127MAP3K140.39329443
128CDK11A0.38722817
129PRKAA10.37833170
130PRKACB0.37714693
131CAMKK20.37275401
132SYK0.36957333
133MAPK70.36886529
134PRKACA0.36761050
135INSRR0.36436404
136OBSCN0.35822296
137PIK3CA0.35503623
138DYRK1A0.34551877
139MKNK20.33711800
140PRKCB0.33548148
141TXK0.31354883
142ITK0.30229331
143NTRK20.30153523
144PRKD10.29979212
145IKBKB0.28014615
146PHKG20.27575692
147PHKG10.27575692
148PIK3CG0.27453600
149PDPK10.26851317
150SGK10.23141139
151MAP3K130.22953501
152LCK0.22642802
153AKT30.22588228
154PLK20.22404460

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.32745605
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.20697628
3Steroid biosynthesis_Homo sapiens_hsa001004.28285792
4Fatty acid elongation_Homo sapiens_hsa000623.97959140
5Ether lipid metabolism_Homo sapiens_hsa005653.41460588
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93552014
7Linoleic acid metabolism_Homo sapiens_hsa005912.51807909
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.50528751
9Oxidative phosphorylation_Homo sapiens_hsa001902.42624637
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40056112
11Protein export_Homo sapiens_hsa030602.17005950
12Axon guidance_Homo sapiens_hsa043602.10591010
13Selenocompound metabolism_Homo sapiens_hsa004502.03604669
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.00481374
15Sphingolipid metabolism_Homo sapiens_hsa006001.90524520
16Tryptophan metabolism_Homo sapiens_hsa003801.87542976
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85997991
18Olfactory transduction_Homo sapiens_hsa047401.81630025
19Sulfur metabolism_Homo sapiens_hsa009201.77803459
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.76650087
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.62086657
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60819749
23Serotonergic synapse_Homo sapiens_hsa047261.58472589
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.57464118
25Alzheimers disease_Homo sapiens_hsa050101.56669234
26Arachidonic acid metabolism_Homo sapiens_hsa005901.54261686
27Collecting duct acid secretion_Homo sapiens_hsa049661.52211902
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51140642
29Parkinsons disease_Homo sapiens_hsa050121.47985805
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.47583387
31Fatty acid biosynthesis_Homo sapiens_hsa000611.46485466
32Rheumatoid arthritis_Homo sapiens_hsa053231.44153014
33Nitrogen metabolism_Homo sapiens_hsa009101.32305881
34Insulin secretion_Homo sapiens_hsa049111.29485367
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28610167
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26591846
37Long-term depression_Homo sapiens_hsa047301.24222245
38Histidine metabolism_Homo sapiens_hsa003401.23665646
39Nicotine addiction_Homo sapiens_hsa050331.23252252
40Non-homologous end-joining_Homo sapiens_hsa034501.19866216
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19862313
42Vibrio cholerae infection_Homo sapiens_hsa051101.17001132
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.14458253
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14242870
45Autoimmune thyroid disease_Homo sapiens_hsa053201.13717589
46Glutamatergic synapse_Homo sapiens_hsa047241.13366715
47Chemical carcinogenesis_Homo sapiens_hsa052041.08131160
48GABAergic synapse_Homo sapiens_hsa047271.06635763
49Phototransduction_Homo sapiens_hsa047441.01779699
50Morphine addiction_Homo sapiens_hsa050321.00927799
51ABC transporters_Homo sapiens_hsa020101.00513896
52Vitamin B6 metabolism_Homo sapiens_hsa007500.96085071
53Gastric acid secretion_Homo sapiens_hsa049710.95842834
54Oxytocin signaling pathway_Homo sapiens_hsa049210.92437504
55Ovarian steroidogenesis_Homo sapiens_hsa049130.91886529
56Phagosome_Homo sapiens_hsa041450.90530834
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88587991
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.86759724
59Homologous recombination_Homo sapiens_hsa034400.86512194
60Huntingtons disease_Homo sapiens_hsa050160.85052610
61Arginine and proline metabolism_Homo sapiens_hsa003300.81668357
62Type I diabetes mellitus_Homo sapiens_hsa049400.78897027
63Ras signaling pathway_Homo sapiens_hsa040140.78404684
64Butanoate metabolism_Homo sapiens_hsa006500.77657453
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76208474
66Graft-versus-host disease_Homo sapiens_hsa053320.76082474
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75083323
68Taste transduction_Homo sapiens_hsa047420.73469906
69Mineral absorption_Homo sapiens_hsa049780.73158008
70Malaria_Homo sapiens_hsa051440.71665982
71Allograft rejection_Homo sapiens_hsa053300.71496787
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.69462334
73Glycerolipid metabolism_Homo sapiens_hsa005610.68166962
74Propanoate metabolism_Homo sapiens_hsa006400.68149415
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66794256
76Proteasome_Homo sapiens_hsa030500.66552675
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.66219429
78cAMP signaling pathway_Homo sapiens_hsa040240.65757016
79Tight junction_Homo sapiens_hsa045300.64785963
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64457060
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.62052815
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61876250
83Cardiac muscle contraction_Homo sapiens_hsa042600.61188033
84Synaptic vesicle cycle_Homo sapiens_hsa047210.60496665
85Glutathione metabolism_Homo sapiens_hsa004800.58528405
86Renal cell carcinoma_Homo sapiens_hsa052110.57943547
87Circadian entrainment_Homo sapiens_hsa047130.56448434
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55707195
89Basal transcription factors_Homo sapiens_hsa030220.53534715
90Asthma_Homo sapiens_hsa053100.52884237
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52237242
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51205139
93Lysine degradation_Homo sapiens_hsa003100.50885770
94Salivary secretion_Homo sapiens_hsa049700.50496037
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.49011920
96Regulation of autophagy_Homo sapiens_hsa041400.48945502
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48743472
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48499373
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47926602
100Fatty acid degradation_Homo sapiens_hsa000710.46927563
101Type II diabetes mellitus_Homo sapiens_hsa049300.46583865
102Circadian rhythm_Homo sapiens_hsa047100.45731986
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44411964
104Peroxisome_Homo sapiens_hsa041460.42958315
105Hedgehog signaling pathway_Homo sapiens_hsa043400.42603088
106RNA polymerase_Homo sapiens_hsa030200.42323639
107ErbB signaling pathway_Homo sapiens_hsa040120.42260354
108Amphetamine addiction_Homo sapiens_hsa050310.41959019
109ECM-receptor interaction_Homo sapiens_hsa045120.40590526
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40544728
111Cholinergic synapse_Homo sapiens_hsa047250.39640951
112Lysosome_Homo sapiens_hsa041420.39422325
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39228186
114Pancreatic secretion_Homo sapiens_hsa049720.38109667
115Cocaine addiction_Homo sapiens_hsa050300.37990640
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37921649
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37686171
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37262995
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36759147
120Metabolic pathways_Homo sapiens_hsa011000.36333727
121Vitamin digestion and absorption_Homo sapiens_hsa049770.36234463
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35412793
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35320369
124Dorso-ventral axis formation_Homo sapiens_hsa043200.35316429
125Fat digestion and absorption_Homo sapiens_hsa049750.34117031
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34040564
127Salmonella infection_Homo sapiens_hsa051320.33955598
128beta-Alanine metabolism_Homo sapiens_hsa004100.33920070
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33293891
130One carbon pool by folate_Homo sapiens_hsa006700.33156070
131Retinol metabolism_Homo sapiens_hsa008300.33062898
132Basal cell carcinoma_Homo sapiens_hsa052170.32841023
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32830278
134Dopaminergic synapse_Homo sapiens_hsa047280.32567325
135Calcium signaling pathway_Homo sapiens_hsa040200.32537297
136MAPK signaling pathway_Homo sapiens_hsa040100.32407356
137Endocytosis_Homo sapiens_hsa041440.30602293
138Purine metabolism_Homo sapiens_hsa002300.30503230
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29582821
140Thyroid hormone synthesis_Homo sapiens_hsa049180.28633938
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26851919
142Renin secretion_Homo sapiens_hsa049240.25700259
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25137650
144Wnt signaling pathway_Homo sapiens_hsa043100.23129066

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