KRT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of gene silencing (GO:0060969)8.54749894
2establishment of skin barrier (GO:0061436)8.11989173
3keratinocyte development (GO:0003334)7.90293796
4regulation of water loss via skin (GO:0033561)7.81168706
5desmosome organization (GO:0002934)7.22026273
6keratinocyte proliferation (GO:0043616)6.80286602
7mesenchymal cell differentiation involved in renal system development (GO:2001012)6.62670000
8mesenchymal cell differentiation involved in kidney development (GO:0072161)6.62670000
9bundle of His cell to Purkinje myocyte communication (GO:0086069)6.59683947
10mechanoreceptor differentiation (GO:0042490)6.57216532
11peptide cross-linking (GO:0018149)6.38975874
12cell differentiation involved in metanephros development (GO:0072202)6.33445007
13hair cell differentiation (GO:0035315)6.14610946
14innervation (GO:0060384)6.11792278
15gap junction assembly (GO:0016264)6.10344045
16keratinocyte differentiation (GO:0030216)6.07999628
17negative regulation of keratinocyte proliferation (GO:0010839)6.01344511
18positive regulation of epidermal cell differentiation (GO:0045606)5.64732436
19epidermal cell differentiation (GO:0009913)5.48610119
20hemidesmosome assembly (GO:0031581)5.33202390
21positive regulation of gastrulation (GO:2000543)5.25917167
22positive regulation of epidermis development (GO:0045684)5.16319633
23multicellular organismal water homeostasis (GO:0050891)5.06779010
24epidermis development (GO:0008544)4.99029465
25cell proliferation involved in metanephros development (GO:0072203)4.96565908
26pattern specification involved in kidney development (GO:0061004)4.87696605
27opioid receptor signaling pathway (GO:0038003)4.66425009
28ribosomal small subunit biogenesis (GO:0042274)4.65945893
29apical protein localization (GO:0045176)4.55833576
30metanephric mesenchyme development (GO:0072075)4.51815468
31establishment of protein localization to mitochondrial membrane (GO:0090151)4.41842832
32galactose catabolic process (GO:0019388)4.35484685
33positive regulation of keratinocyte differentiation (GO:0045618)4.24572371
34regulation of apoptotic process involved in morphogenesis (GO:1902337)4.19395029
35kidney mesenchyme development (GO:0072074)4.15767415
36molting cycle (GO:0042303)4.09067356
37hair cycle (GO:0042633)4.09067356
38water homeostasis (GO:0030104)4.08205827
39interleukin-6-mediated signaling pathway (GO:0070102)4.02520459
40regulation of neuron projection regeneration (GO:0070570)4.01139941
41regulation of axon regeneration (GO:0048679)4.01139941
42regulation of hypersensitivity (GO:0002883)3.97900613
43mesonephros development (GO:0001823)3.85122544
44long-chain fatty acid biosynthetic process (GO:0042759)3.83225861
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.79771385
46localization within membrane (GO:0051668)3.75249031
47ribosomal large subunit biogenesis (GO:0042273)3.75213106
48negative regulation of kidney development (GO:0090185)3.57835706
49urogenital system development (GO:0001655)3.55502998
50negative regulation of glial cell proliferation (GO:0060253)3.53764147
51lipoxygenase pathway (GO:0019372)3.52048242
52respiratory electron transport chain (GO:0022904)3.49294860
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.45678727
54cell proliferation involved in kidney development (GO:0072111)3.43605847
55electron transport chain (GO:0022900)3.42213597
56nephron tubule morphogenesis (GO:0072078)3.39684832
57nephron epithelium morphogenesis (GO:0072088)3.39684832
58negative regulation of acute inflammatory response (GO:0002674)3.38160626
59oligosaccharide catabolic process (GO:0009313)3.36153667
60maturation of SSU-rRNA (GO:0030490)3.29006823
61positive regulation of chemokine secretion (GO:0090197)3.27723152
62skin morphogenesis (GO:0043589)3.27693820
63thalamus development (GO:0021794)3.19505804
64ATP synthesis coupled proton transport (GO:0015986)3.16777230
65energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16777230
66forebrain neuron development (GO:0021884)3.15827483
67urea cycle (GO:0000050)3.14703685
68protein localization to endosome (GO:0036010)3.11349647
69ER overload response (GO:0006983)3.11038096
70regulation of gene silencing (GO:0060968)3.10478350
71metanephric tubule development (GO:0072170)3.09781345
72metanephric nephron tubule development (GO:0072234)3.09781345
73embryonic skeletal joint morphogenesis (GO:0060272)3.07823528
74G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.03692225
75skeletal muscle tissue regeneration (GO:0043403)3.03583080
76asymmetric protein localization (GO:0008105)3.02127251
77single strand break repair (GO:0000012)2.99094002
78protein complex biogenesis (GO:0070271)2.97964238
79regulation of keratinocyte proliferation (GO:0010837)2.97469147
80endothelial cell chemotaxis (GO:0035767)2.96680639
81cerebellar Purkinje cell layer development (GO:0021680)2.96615054
82negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.93601101
83arginine metabolic process (GO:0006525)2.93185587
84galactose metabolic process (GO:0006012)2.89929077
85chemosensory behavior (GO:0007635)2.88783161
86GDP-mannose metabolic process (GO:0019673)2.88677900
87retrograde transport, vesicle recycling within Golgi (GO:0000301)2.86294168
88membrane raft organization (GO:0031579)2.82821824
89membrane tubulation (GO:0097320)2.82343966
90urea metabolic process (GO:0019627)2.79361080
91regulation of epidermis development (GO:0045682)2.78692250
92protein targeting to Golgi (GO:0000042)2.78601108
93metanephric nephron epithelium development (GO:0072243)2.77866471
94regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.77670766
95mesenchyme morphogenesis (GO:0072132)2.77577329
96NADH dehydrogenase complex assembly (GO:0010257)2.77120935
97keratinization (GO:0031424)11.5228918
98regulation of posttranscriptional gene silencing (GO:0060147)10.1893496
99regulation of gene silencing by miRNA (GO:0060964)10.1893496
100regulation of gene silencing by RNA (GO:0060966)10.1893496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.01313330
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.24966850
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.95313967
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.46729478
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.36474531
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30178175
7IKZF1_21737484_ChIP-ChIP_HCT116_Human3.24026538
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.23937983
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37004192
10GATA3_20176728_ChIP-ChIP_TSCs_Mouse2.17955799
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16897696
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.01335327
13TP63_17297297_ChIP-ChIP_HaCaT_Human13.0726422
14TP63_22573176_ChIP-Seq_HFKS_Human1.93652601
15SOX9_24532713_ChIP-Seq_HFSC_Mouse1.77835476
16ZNF263_19887448_ChIP-Seq_K562_Human1.73639987
17EGR1_19032775_ChIP-ChIP_M12_Human1.66977701
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.58057825
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.58057825
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54586380
21ATF3_27146783_Chip-Seq_COLON_Human1.54547390
22CTCF_27219007_Chip-Seq_Bcells_Human1.53132689
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49617555
24LXR_22292898_ChIP-Seq_THP-1_Human1.48301979
25EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47059362
26CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45978314
27RACK7_27058665_Chip-Seq_MCF-7_Human1.35285747
28ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.31731441
29KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29504400
30TP63_23658742_ChIP-Seq_EP156T_Human1.27628214
31SOX2_20726797_ChIP-Seq_SW620_Human1.27624593
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27010647
33SA1_27219007_Chip-Seq_ERYTHROID_Human1.24024952
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21441722
35BCOR_27268052_Chip-Seq_Bcells_Human1.21295051
36STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.20546496
37BCL6_27268052_Chip-Seq_Bcells_Human1.20155244
38ELF5_23300383_ChIP-Seq_T47D_Human1.17136466
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.16907226
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13833378
41CTCF_20526341_ChIP-Seq_ESCs_Human1.13241512
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12715603
43P53_21459846_ChIP-Seq_SAOS-2_Human1.09063031
44SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08490198
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.08368119
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.08307380
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05892848
48JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04913808
49AR_21572438_ChIP-Seq_LNCaP_Human1.04643441
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.03750385
51TP53_16413492_ChIP-PET_HCT116_Human1.03339485
52E2F1_20622854_ChIP-Seq_HELA_Human1.02953739
53P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.00889811
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96969415
55DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96943739
56UBF1/2_26484160_Chip-Seq_HMECs_Human0.96686911
57ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96152576
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95741078
59ELK1_22589737_ChIP-Seq_MCF10A_Human0.95288862
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95100625
61ELK3_25401928_ChIP-Seq_HUVEC_Human0.94210997
62GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93751471
63TP53_20018659_ChIP-ChIP_R1E_Mouse0.93312640
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92595908
65ERG_20517297_ChIP-Seq_VCAP_Human0.92262134
66* GATA6_25053715_ChIP-Seq_YYC3_Human0.90836446
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90142083
68CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87773167
69TP53_22127205_ChIP-Seq_IMR90_Human0.87343260
70SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86157218
71CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84393697
72FOXH1_21741376_ChIP-Seq_EPCs_Human0.82944149
73NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81345430
74SMC4_20622854_ChIP-Seq_HELA_Human0.81006706
75KLF5_25053715_ChIP-Seq_YYC3_Human0.80726310
76* GATA3_24758297_ChIP-Seq_MCF-7_Human0.80443971
77ETS1_20019798_ChIP-Seq_JURKAT_Human0.79969665
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.79902590
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79779021
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79735550
81SA1_27219007_Chip-Seq_Bcells_Human0.78966625
82PHF8_20622854_ChIP-Seq_HELA_Human0.76148131
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75379102
84TP53_18474530_ChIP-ChIP_U2OS_Human0.75304189
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.73773442
86DCP1A_22483619_ChIP-Seq_HELA_Human0.73187800
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.72483480
88* CREB1_26743006_Chip-Seq_LNCaP_Human0.71554023
89SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71086098
90RARA_24833708_ChIP-Seq_LIVER_Mouse0.70836819
91SUZ12_27294783_Chip-Seq_ESCs_Mouse0.70429989
92EZH2_27294783_Chip-Seq_ESCs_Mouse0.69994228
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.69609181
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68871367
95CTCF_21964334_Chip-Seq_Bcells_Human0.68830346
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.68643563
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.67836403
98CJUN_26792858_Chip-Seq_BT549_Human0.66068301
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.65929515
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.65902477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.86470420
2MP0000579_abnormal_nail_morphology5.26619225
3MP0005275_abnormal_skin_tensile5.25833499
4MP0004043_abnormal_pH_regulation4.98662558
5MP0005501_abnormal_skin_physiology4.31522559
6MP0004885_abnormal_endolymph3.50635356
7MP0010678_abnormal_skin_adnexa3.37450812
8MP0002098_abnormal_vibrissa_morphology2.92789757
9MP0002234_abnormal_pharynx_morphology2.89013002
10MP0009053_abnormal_anal_canal2.77585888
11MP0004264_abnormal_extraembryonic_tissu2.74336036
12MP0003453_abnormal_keratinocyte_physiol2.61255291
13MP0001216_abnormal_epidermal_layer2.50648408
14MP0003787_abnormal_imprinting2.39203637
15MP0010771_integument_phenotype2.19092964
16MP0003123_paternal_imprinting2.08705814
17MP0000377_abnormal_hair_follicle2.01598617
18MP0010234_abnormal_vibrissa_follicle10.6529712
19MP0000427_abnormal_hair_cycle1.97304490
20MP0004185_abnormal_adipocyte_glucose1.96366376
21MP0003315_abnormal_perineum_morphology1.91642852
22MP0005409_darkened_coat_color1.76420078
23MP0000467_abnormal_esophagus_morphology1.65316529
24MP0004381_abnormal_hair_follicle1.61794191
25MP0002060_abnormal_skin_morphology1.58129411
26MP0005377_hearing/vestibular/ear_phenot1.48485981
27MP0003878_abnormal_ear_physiology1.48485981
28MP0001984_abnormal_olfaction1.44893206
29MP0009379_abnormal_foot_pigmentation1.38920885
30MP0000013_abnormal_adipose_tissue1.34532704
31MP0002254_reproductive_system_inflammat1.32675841
32MP0000383_abnormal_hair_follicle1.30634644
33MP0000647_abnormal_sebaceous_gland1.19136910
34MP0003566_abnormal_cell_adhesion1.13930260
35MP0001764_abnormal_homeostasis1.11503981
36MP0009931_abnormal_skin_appearance1.08806397
37MP0002095_abnormal_skin_pigmentation1.08099119
38MP0000367_abnormal_coat/_hair1.07831205
39MP0000762_abnormal_tongue_morphology1.05284875
40MP0000566_synostosis1.03952301
41MP0002009_preneoplasia1.01904640
42MP0005193_abnormal_anterior_eye1.00228586
43MP0001191_abnormal_skin_condition0.98870168
44MP0003950_abnormal_plasma_membrane0.97629464
45MP0003638_abnormal_response/metabolism_0.91258444
46MP0002837_dystrophic_cardiac_calcinosis0.87962029
47MP0005670_abnormal_white_adipose0.82521426
48MP0009780_abnormal_chondrocyte_physiolo0.75681766
49MP0003941_abnormal_skin_development0.75600965
50MP0002736_abnormal_nociception_after0.74515433
51MP0001243_abnormal_dermal_layer0.72154115
52MP0000490_abnormal_crypts_of0.70960710
53MP0004782_abnormal_surfactant_physiolog0.68804586
54MP0002877_abnormal_melanocyte_morpholog0.60264577
55MP0004947_skin_inflammation0.60191729
56MP0005666_abnormal_adipose_tissue0.60073437
57MP0000750_abnormal_muscle_regeneration0.59957944
58MP0001905_abnormal_dopamine_level0.56426190
59MP0009115_abnormal_fat_cell0.54427531
60MP0008873_increased_physiological_sensi0.54039134
61MP0000627_abnormal_mammary_gland0.53997137
62MP0005375_adipose_tissue_phenotype0.53535989
63MP0006036_abnormal_mitochondrial_physio0.53498221
64MP0001346_abnormal_lacrimal_gland0.50232070
65MP0002970_abnormal_white_adipose0.48151867
66MP0004019_abnormal_vitamin_homeostasis0.44033232
67MP0002233_abnormal_nose_morphology0.42232582
68MP0004270_analgesia0.41139123
69MP0004233_abnormal_muscle_weight0.39586488
70MP0001784_abnormal_fluid_regulation0.38566807
71MP0005023_abnormal_wound_healing0.37662922
72MP0001661_extended_life_span0.36723417
73MP0003329_amyloid_beta_deposits0.35834717
74MP0003011_delayed_dark_adaptation0.34462439
75MP0001851_eye_inflammation0.34326302
76MP0003806_abnormal_nucleotide_metabolis0.32698632
77MP0004272_abnormal_basement_membrane0.31934896
78MP0001958_emphysema0.30762167
79MP0001340_abnormal_eyelid_morphology0.30450898
80MP0000372_irregular_coat_pigmentation0.30440619
81MP0009765_abnormal_xenobiotic_induced0.29687220
82MP0000003_abnormal_adipose_tissue0.29671643
83MP0008260_abnormal_autophagy0.28827064
84MP0003937_abnormal_limbs/digits/tail_de0.28819721
85MP0005376_homeostasis/metabolism_phenot0.27535800
86MP0003755_abnormal_palate_morphology0.24503966
87MP0008569_lethality_at_weaning0.22616767
88MP0002019_abnormal_tumor_incidence0.21230735
89MP0001853_heart_inflammation0.21221223
90MP0000477_abnormal_intestine_morphology0.20962735
91MP0005332_abnormal_amino_acid0.19231840
92MP0002295_abnormal_pulmonary_circulatio0.18296815
93MP0001919_abnormal_reproductive_system0.17993761
94MP0002135_abnormal_kidney_morphology0.17406648
95MP0001727_abnormal_embryo_implantation0.17163423
96MP0003121_genomic_imprinting0.17010855
97MP0002111_abnormal_tail_morphology0.16202763
98MP0003705_abnormal_hypodermis_morpholog0.15452457
99MP0003186_abnormal_redox_activity0.13403749
100MP0005671_abnormal_response_to0.12086348

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.79374527
2Fragile nails (HP:0001808)8.35332810
3Alopecia of scalp (HP:0002293)7.84000367
4Abnormality of nail color (HP:0100643)7.49053423
5Oral leukoplakia (HP:0002745)7.07613877
6Erythroderma (HP:0001019)6.90986014
7Increased IgE level (HP:0003212)6.85902795
8Congenital ichthyosiform erythroderma (HP:0007431)6.46275937
9Palmoplantar hyperkeratosis (HP:0000972)6.07243133
10Plantar hyperkeratosis (HP:0007556)5.77872647
11Palmar hyperkeratosis (HP:0010765)5.68882308
12Abnormality of placental membranes (HP:0011409)5.55429776
13Amniotic constriction ring (HP:0009775)5.55429776
14Woolly hair (HP:0002224)4.74320060
15Abnormality of small intestinal villus morphology (HP:0011472)4.63026008
16Villous atrophy (HP:0011473)4.63026008
17Brittle hair (HP:0002299)4.48407502
18Onycholysis (HP:0001806)4.19496600
19Sparse scalp hair (HP:0002209)4.11715673
20Recurrent corneal erosions (HP:0000495)4.01274884
21* Corneal dystrophy (HP:0001131)3.94890058
22Parakeratosis (HP:0001036)3.93657739
23Sparse eyelashes (HP:0000653)3.75805128
24Erythema (HP:0010783)3.73903376
25Autoamputation (HP:0001218)3.68670247
26Acanthosis nigricans (HP:0000956)3.63115559
27Corneal erosion (HP:0200020)3.29547401
28Absent eyelashes (HP:0000561)3.27046186
29Pustule (HP:0200039)3.17001246
30Nail dystrophy (HP:0008404)3.14877309
31Hypotrichosis (HP:0001006)3.10248605
32Milia (HP:0001056)3.09792019
33Right ventricular cardiomyopathy (HP:0011663)2.96228830
34Urticaria (HP:0001025)2.85119922
35Squamous cell carcinoma (HP:0002860)2.84916632
36Chronic hepatic failure (HP:0100626)2.74201307
37Thick nail (HP:0001805)2.72779020
38Pili torti (HP:0003777)2.66696105
39Hypokinesia (HP:0002375)2.66006712
40Ridged nail (HP:0001807)2.62910923
41Amelogenesis imperfecta (HP:0000705)2.45307249
42Furrowed tongue (HP:0000221)2.38638005
43Abnormality of liposaccharide metabolism (HP:0010968)2.38056192
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.38056192
45Abnormality of glycolipid metabolism (HP:0010969)2.38056192
46Dry hair (HP:0011359)2.34459661
47Absent hair (HP:0002298)2.27030077
48Entropion (HP:0000621)2.25219524
49Fine hair (HP:0002213)2.21187932
50Abnormality of dental color (HP:0011073)2.20973363
51Premature ovarian failure (HP:0008209)2.19051926
52Hypergammaglobulinemia (HP:0010702)2.17625782
53Hypohidrosis (HP:0000966)2.16642683
54Palmoplantar keratoderma (HP:0000982)2.16607459
55Follicular hyperkeratosis (HP:0007502)2.15600167
56Acute necrotizing encephalopathy (HP:0006965)2.11047363
57Recurrent bacterial skin infections (HP:0005406)2.07445602
58Trismus (HP:0000211)2.05107218
59Abnormal blistering of the skin (HP:0008066)2.03960893
60* Nonprogressive disorder (HP:0003680)10.3918632
61Poikiloderma (HP:0001029)1.99999468
62Abnormality of the neuromuscular junction (HP:0003398)1.99313717
63Fatigable weakness (HP:0003473)1.99313717
64Abnormal hair laboratory examination (HP:0003328)1.97269650
65Keratoconjunctivitis sicca (HP:0001097)1.94787338
66Redundant skin (HP:0001582)1.93495332
67Abnormal mitochondria in muscle tissue (HP:0008316)1.92927387
68Ectropion (HP:0000656)1.89567519
69Reticulocytopenia (HP:0001896)1.89475000
70Spastic paraparesis (HP:0002313)1.86520196
71Abnormality of DNA repair (HP:0003254)1.85825062
72Oligodontia (HP:0000677)1.84773991
73Acute encephalopathy (HP:0006846)1.83772304
74Knee flexion contracture (HP:0006380)1.82777848
75Elbow flexion contracture (HP:0002987)1.82537464
76Atrophic scars (HP:0001075)1.79203029
77Microvesicular hepatic steatosis (HP:0001414)1.76785927
78Hypoplastic toenails (HP:0001800)1.76533854
79Keratoconjunctivitis (HP:0001096)1.75447753
80* Opacification of the corneal stroma (HP:0007759)1.75046248
81Multifactorial inheritance (HP:0001426)1.73581541
82Keratitis (HP:0000491)1.68322265
83Progressive macrocephaly (HP:0004481)1.66115720
84Cerebral edema (HP:0002181)1.65993686
85Lip pit (HP:0100267)1.64779291
86Congenital, generalized hypertrichosis (HP:0004540)1.62769400
87Distal lower limb muscle weakness (HP:0009053)1.61002076
88Akinesia (HP:0002304)1.57423186
89Diminished movement (HP:0002374)1.56262975
90Decreased subcutaneous fat (HP:0001002)1.49437335
91Down-sloping shoulders (HP:0200021)1.48413166
923-Methylglutaconic aciduria (HP:0003535)1.46878301
93Abnormalities of placenta or umbilical cord (HP:0001194)1.45383937
94Mitral stenosis (HP:0001718)1.44020977
95Dehydration (HP:0001944)1.40310371
96Poor head control (HP:0002421)1.39807135
97Abnormality of the axillary hair (HP:0100134)1.39747461
98Abnormality of secondary sexual hair (HP:0009888)1.39747461
99Carious teeth (HP:0000670)1.39095205
100Concave nail (HP:0001598)1.37608661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.18309047
2STK164.46059166
3WNK14.33346242
4GRK74.09261025
5MST43.47049635
6CDK193.17539313
7TESK12.97454999
8EPHB22.76090059
9STK242.52764165
10PHKG12.49121892
11PHKG22.49121892
12ABL22.42482144
13MAPKAPK32.35035272
14PRKD22.22260157
15GRK52.20370510
16TGFBR22.19594631
17STK102.06836575
18MOS2.03115757
19DMPK1.87481420
20MAP3K21.69018447
21GRK61.66804823
22MAP3K31.63978338
23IRAK21.63162058
24MST1R1.58829599
25RPS6KB21.50684782
26MATK1.48411867
27LIMK11.48045089
28MARK11.46492343
29MAP3K61.39258698
30CDK121.33050054
31ADRBK11.32247717
32NTRK11.19192977
33PINK11.14407054
34PTK21.00727630
35MAPK70.91391473
36EPHA20.90963909
37IRAK30.87720257
38MAP3K110.76018611
39CHEK20.75906772
40MAPKAPK20.71653351
41ILK0.71392195
42MAP3K120.68537391
43TBK10.65256204
44SCYL20.62035039
45PRKCI0.61304010
46HIPK20.60537340
47CDK11A0.59753600
48PBK0.59740052
49DAPK30.58328814
50PIM20.57371055
51PRKD10.57332082
52AURKA0.56276238
53GRK10.56001536
54CSNK1G10.55561299
55TESK20.53075498
56TAOK10.51610626
57EIF2AK20.49093966
58CSK0.46830988
59PRKG10.44890570
60MYLK0.43840818
61DDR20.41541109
62CSNK1G30.41309810
63CDC42BPA0.36987525
64PDGFRB0.35932201
65PAK20.32504505
66CDK140.31863047
67MET0.30720715
68FGR0.29182488
69FGFR30.28604795
70BLK0.28441700
71PTK60.28317010
72CSNK2A10.28281124
73NME10.27952793
74PTK2B0.27664337
75CSNK1E0.27583296
76PRKCH0.26952870
77CSNK1A10.26439093
78PDPK10.25670458
79CSNK1A1L0.25616516
80IGF1R0.25052490
81NME20.23748902
82CDK90.23345735
83MAP3K50.22709083
84PAK30.22450912
85MARK30.22082643
86ABL10.21327162
87PRKACA0.20021836
88PRKCD0.19171409
89PLK20.17903752
90PRKACB0.17838057
91CDK150.17644566
92CSNK2A20.16841248
93MAPK140.16677602
94MAPK40.16389132
95INSR0.15650648
96CSNK1G20.15593889
97CDK180.15491909
98PRKCA0.14350291
99CSNK1D0.13823011
100PKN10.11197982

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.71640587
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.17609205
3Ribosome_Homo sapiens_hsa030103.79145786
4Arginine biosynthesis_Homo sapiens_hsa002203.72434506
5Parkinsons disease_Homo sapiens_hsa050123.37561356
6RNA polymerase_Homo sapiens_hsa030203.08490907
7Alzheimers disease_Homo sapiens_hsa050102.90230066
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.55019598
9Huntingtons disease_Homo sapiens_hsa050162.51567673
10Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.27636484
11Collecting duct acid secretion_Homo sapiens_hsa049661.99486587
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92709928
13Phototransduction_Homo sapiens_hsa047441.90133186
14Proteasome_Homo sapiens_hsa030501.85049367
15Arginine and proline metabolism_Homo sapiens_hsa003301.79490730
16Cardiac muscle contraction_Homo sapiens_hsa042601.78409996
17p53 signaling pathway_Homo sapiens_hsa041151.74358655
18Sulfur relay system_Homo sapiens_hsa041221.67507363
19Other glycan degradation_Homo sapiens_hsa005111.58048247
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54493500
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51803898
22Sphingolipid metabolism_Homo sapiens_hsa006001.43894500
23Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.39265605
24Galactose metabolism_Homo sapiens_hsa000521.39253143
25Arachidonic acid metabolism_Homo sapiens_hsa005901.36881952
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33479551
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.32081026
28Histidine metabolism_Homo sapiens_hsa003401.28928625
29Hedgehog signaling pathway_Homo sapiens_hsa043401.26731779
30Nucleotide excision repair_Homo sapiens_hsa034201.23693746
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23473034
32Shigellosis_Homo sapiens_hsa051311.16213204
33Tight junction_Homo sapiens_hsa045301.15470160
34Mineral absorption_Homo sapiens_hsa049781.13021635
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11547577
36Base excision repair_Homo sapiens_hsa034101.04524529
37Steroid biosynthesis_Homo sapiens_hsa001001.01906421
38Synaptic vesicle cycle_Homo sapiens_hsa047211.00682542
39Salmonella infection_Homo sapiens_hsa051320.98340395
40beta-Alanine metabolism_Homo sapiens_hsa004100.96232508
41Vibrio cholerae infection_Homo sapiens_hsa051100.93536695
42Linoleic acid metabolism_Homo sapiens_hsa005910.92737883
43Endocytosis_Homo sapiens_hsa041440.89863798
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.88328528
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84173599
46Pyrimidine metabolism_Homo sapiens_hsa002400.83012439
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82391827
48Amoebiasis_Homo sapiens_hsa051460.80532739
49Basal cell carcinoma_Homo sapiens_hsa052170.74586695
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73989595
51Basal transcription factors_Homo sapiens_hsa030220.73859096
52Metabolic pathways_Homo sapiens_hsa011000.73671751
53Homologous recombination_Homo sapiens_hsa034400.67037328
54VEGF signaling pathway_Homo sapiens_hsa043700.66862995
55Retinol metabolism_Homo sapiens_hsa008300.66858223
56Ether lipid metabolism_Homo sapiens_hsa005650.66096936
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65531392
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64972310
59Lysosome_Homo sapiens_hsa041420.63019854
60Glycerolipid metabolism_Homo sapiens_hsa005610.62706834
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61047536
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60471099
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59501948
64Renal cell carcinoma_Homo sapiens_hsa052110.58445262
65Serotonergic synapse_Homo sapiens_hsa047260.58004505
66ECM-receptor interaction_Homo sapiens_hsa045120.57443421
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55667893
68Glutathione metabolism_Homo sapiens_hsa004800.54891129
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54052280
70Tyrosine metabolism_Homo sapiens_hsa003500.53038497
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50521015
72GnRH signaling pathway_Homo sapiens_hsa049120.47798905
73MAPK signaling pathway_Homo sapiens_hsa040100.46770163
74Calcium signaling pathway_Homo sapiens_hsa040200.46514802
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45410905
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.45289568
77Fructose and mannose metabolism_Homo sapiens_hsa000510.44053048
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42070603
79Phagosome_Homo sapiens_hsa041450.41996638
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39475281
81Regulation of autophagy_Homo sapiens_hsa041400.39394798
82PPAR signaling pathway_Homo sapiens_hsa033200.39072249
83Renin secretion_Homo sapiens_hsa049240.38613544
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34869471
85Salivary secretion_Homo sapiens_hsa049700.34578847
86Chemical carcinogenesis_Homo sapiens_hsa052040.34561745
87Pancreatic secretion_Homo sapiens_hsa049720.32744927
88Olfactory transduction_Homo sapiens_hsa047400.30831785
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30751378
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30626401
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.28368848
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28363785
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28304972
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25926964
95Fatty acid elongation_Homo sapiens_hsa000620.24376045
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23891050
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23677531
98Purine metabolism_Homo sapiens_hsa002300.23401611
99Hippo signaling pathway_Homo sapiens_hsa043900.22996337
100Epstein-Barr virus infection_Homo sapiens_hsa051690.22193096

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