KRT32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)8.51000274
2adhesion of symbiont to host cell (GO:0044650)8.18476261
3virion attachment to host cell (GO:0019062)8.18476261
4hair follicle morphogenesis (GO:0031069)7.73835703
5citrulline biosynthetic process (GO:0019240)7.23512591
6establishment of skin barrier (GO:0061436)7.19039135
7adhesion of symbiont to host (GO:0044406)6.87770060
8cell wall macromolecule metabolic process (GO:0044036)6.49933081
9cell wall macromolecule catabolic process (GO:0016998)6.49933081
10regulation of water loss via skin (GO:0033561)6.36190588
11keratinocyte differentiation (GO:0030216)6.12816439
12intermediate filament cytoskeleton organization (GO:0045104)5.89784642
13* epidermis development (GO:0008544)5.86520875
14intermediate filament-based process (GO:0045103)5.71555451
15hemidesmosome assembly (GO:0031581)5.48616620
16bundle of His cell to Purkinje myocyte communication (GO:0086069)5.44291446
17hair cycle process (GO:0022405)5.26333437
18molting cycle process (GO:0022404)5.26333437
19skin morphogenesis (GO:0043589)5.07537742
20negative regulation of keratinocyte proliferation (GO:0010839)5.04255941
21epidermal cell differentiation (GO:0009913)4.92944700
22tooth mineralization (GO:0034505)4.87307021
23lymph vessel development (GO:0001945)4.70777773
24positive regulation of hair follicle development (GO:0051798)4.62629997
25positive regulation of hair cycle (GO:0042635)4.62629997
26citrulline metabolic process (GO:0000052)4.60854030
27multicellular organismal water homeostasis (GO:0050891)4.34255290
28keratinocyte development (GO:0003334)4.34006291
29regulation of hair follicle development (GO:0051797)4.05085433
30regulation of keratinocyte differentiation (GO:0045616)3.89425210
31peptidyl-arginine modification (GO:0018195)3.69776467
32positive regulation of epidermis development (GO:0045684)3.67401735
33water homeostasis (GO:0030104)3.55860495
34keratinocyte proliferation (GO:0043616)3.47254111
35regulation of hair cycle (GO:0042634)3.44851257
36hair follicle development (GO:0001942)3.43512028
37atrioventricular valve morphogenesis (GO:0003181)3.36518115
38regulation of mesenchymal cell apoptotic process (GO:2001053)3.31582238
39regulation of epidermis development (GO:0045682)3.11203042
40G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.04400251
41molting cycle (GO:0042303)28.9647597
42hair cycle (GO:0042633)28.9647597
43regulation of epidermal cell differentiation (GO:0045604)2.96615352
44* epithelium development (GO:0060429)2.91104391
45negative regulation of cell fate specification (GO:0009996)2.90912873
46positive regulation of epidermal cell differentiation (GO:0045606)2.86377405
47regulation of cardioblast proliferation (GO:0003264)2.85286280
48regulation of secondary heart field cardioblast proliferation (GO:0003266)2.85286280
49fatty acid elongation (GO:0030497)2.84504734
50bone trabecula formation (GO:0060346)2.84448010
51epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.83761576
52ectoderm development (GO:0007398)2.80594884
53phosphatidylinositol acyl-chain remodeling (GO:0036149)2.79414644
54positive regulation of meiotic cell cycle (GO:0051446)2.77711875
55regulation of phospholipase A2 activity (GO:0032429)2.77219443
56regulation of keratinocyte proliferation (GO:0010837)2.76935240
57regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.71191681
58outer ear morphogenesis (GO:0042473)2.68991575
59negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.68721677
60regulation of ruffle assembly (GO:1900027)2.61821713
61planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61039777
62coronary vasculature morphogenesis (GO:0060977)2.60197567
63cell surface receptor signaling pathway involved in heart development (GO:0061311)2.59727906
64negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.58375258
65phosphatidylserine acyl-chain remodeling (GO:0036150)2.57082825
66regulation of skeletal muscle cell differentiation (GO:2001014)2.53070292
67gap junction assembly (GO:0016264)2.51945030
68non-canonical Wnt signaling pathway (GO:0035567)2.51635936
69outflow tract septum morphogenesis (GO:0003148)2.51134127
70chondrocyte development (GO:0002063)2.48876473
71ephrin receptor signaling pathway (GO:0048013)2.41578147
72ventricular cardiac muscle cell action potential (GO:0086005)2.41574203
73muscle organ morphogenesis (GO:0048644)2.39961825
74negative regulation of epidermis development (GO:0045683)2.39619157
75regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.37374527
76skin development (GO:0043588)2.33983431
77odontogenesis of dentin-containing tooth (GO:0042475)2.31133029
78negative regulation of cell fate commitment (GO:0010454)2.28236139
79wound healing, spreading of epidermal cells (GO:0035313)2.26261819
80positive regulation of monocyte chemotaxis (GO:0090026)2.24013140
81phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.22081181
82negative regulation of protein localization to plasma membrane (GO:1903077)2.20916255
83regulation of cardioblast differentiation (GO:0051890)2.17125138
84regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.15682631
85regulation of transforming growth factor beta2 production (GO:0032909)2.15083595
86lateral sprouting from an epithelium (GO:0060601)2.14063484
87establishment of planar polarity (GO:0001736)2.12691283
88establishment of tissue polarity (GO:0007164)2.12691283
89odontogenesis (GO:0042476)2.11467514
90muscle cell fate commitment (GO:0042693)2.10832739
91cell communication involved in cardiac conduction (GO:0086065)2.09841778
92embryonic viscerocranium morphogenesis (GO:0048703)2.04404690
93myotube differentiation (GO:0014902)2.03167282
94cranial suture morphogenesis (GO:0060363)2.02948205
95regulation of heart morphogenesis (GO:2000826)2.02624532
96cytoskeletal anchoring at plasma membrane (GO:0007016)2.01298996
97sphingosine metabolic process (GO:0006670)2.00155165
98desmosome organization (GO:0002934)11.9003342
99keratinization (GO:0031424)11.7013040
100intermediate filament organization (GO:0045109)10.7118874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.30977196
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.31217075
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.16375810
4* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.27103313
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.22066397
6* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.16714651
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.09710701
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.07531116
9TP63_17297297_ChIP-ChIP_HaCaT_Human12.8195427
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83490289
11AR_21572438_ChIP-Seq_LNCaP_Human1.83367830
12CTCF_20526341_ChIP-Seq_ESCs_Human1.78901704
13BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.78058092
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66758301
15TP53_20018659_ChIP-ChIP_R1E_Mouse1.63345944
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.57031185
17EGR1_19032775_ChIP-ChIP_M12_Human1.52458398
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51097215
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51097215
20P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.49377154
21CTCF_27219007_Chip-Seq_Bcells_Human1.49136467
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.47761428
23* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.44534507
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42418628
25NANOG_20526341_ChIP-Seq_ESCs_Human1.38389252
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37304198
27VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.36561335
28TP63_22573176_ChIP-Seq_HFKS_Human1.36228091
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34177651
30CSB_26484114_Chip-Seq_FIBROBLAST_Human1.33830144
31TAF2_19829295_ChIP-Seq_ESCs_Human1.29315599
32* RACK7_27058665_Chip-Seq_MCF-7_Human1.26305666
33TP63_23658742_ChIP-Seq_EP156T_Human1.25950280
34MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.24264708
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.22485955
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21312668
37AHR_22903824_ChIP-Seq_MCF-7_Human1.21043711
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20559338
39LXR_22292898_ChIP-Seq_THP-1_Human1.20103165
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.18975465
41TP53_18474530_ChIP-ChIP_U2OS_Human1.18313629
42YY1_22570637_ChIP-Seq_MALME-3M_Human1.16659625
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15049131
44ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14934281
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.14743214
46* E2F1_20622854_ChIP-Seq_HELA_Human1.14727266
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12706812
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07625822
49* P53_21459846_ChIP-Seq_SAOS-2_Human1.07552432
50SOX2_20726797_ChIP-Seq_SW620_Human1.07303192
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.06998705
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06436398
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06374010
54KLF5_25053715_ChIP-Seq_YYC3_Human1.04368743
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04228898
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.03384020
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03293624
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02066693
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02066693
60* ERG_20517297_ChIP-Seq_VCAP_Human1.01190161
61GATA4_25053715_ChIP-Seq_YYC3_Human1.01148161
62JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00848288
63BCOR_27268052_Chip-Seq_Bcells_Human1.00021026
64SA1_27219007_Chip-Seq_ERYTHROID_Human0.99661157
65GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99448242
66RXR_22108803_ChIP-Seq_LS180_Human0.99175678
67JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99037339
68RING1B_27294783_Chip-Seq_ESCs_Mouse0.98772262
69* GATA3_24758297_ChIP-Seq_MCF-7_Human0.97864915
70EED_16625203_ChIP-ChIP_MESCs_Mouse0.97813459
71* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96147060
72* ATF3_27146783_Chip-Seq_COLON_Human0.95729520
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95489183
74UBF1/2_26484160_Chip-Seq_HMECs_Human0.95265168
75CJUN_26792858_Chip-Seq_BT549_Human0.93648125
76RUNX1_27514584_Chip-Seq_MCF-7_Human0.93561108
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93336925
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93090562
79ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92994104
80* CEBPB_22108803_ChIP-Seq_LS180_Human0.92823562
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92672075
82GATA6_21074721_ChIP-Seq_CACO-2_Human0.90580764
83* BCL6_27268052_Chip-Seq_Bcells_Human0.90090653
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87121168
85IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84858930
86P68_20966046_ChIP-Seq_HELA_Human0.82929141
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82926105
88SMC4_20622854_ChIP-Seq_HELA_Human0.81564967
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81404213
90FOXH1_21741376_ChIP-Seq_ESCs_Human0.80599202
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.80070015
92TCF4_18268006_ChIP-ChIP_LS174T_Human0.79866279
93E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79837394
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.78982331
95BCAT_22108803_ChIP-Seq_LS180_Human0.78339169
96* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78124375
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.77820633
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.75056219
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74223413
100MTF2_20144788_ChIP-Seq_MESCs_Mouse0.74070379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology6.90489336
2MP0002098_abnormal_vibrissa_morphology6.42923776
3MP0002796_impaired_skin_barrier6.01241944
4MP0010234_abnormal_vibrissa_follicle5.87038531
5MP0000647_abnormal_sebaceous_gland5.56999588
6MP0005275_abnormal_skin_tensile5.40415319
7MP0000383_abnormal_hair_follicle4.33286438
8MP0010678_abnormal_skin_adnexa4.05279947
9MP0000377_abnormal_hair_follicle3.86259754
10MP0005501_abnormal_skin_physiology3.78693654
11MP0003705_abnormal_hypodermis_morpholog3.66454907
12MP0000427_abnormal_hair_cycle3.30747509
13MP0002254_reproductive_system_inflammat3.22773684
14MP0001216_abnormal_epidermal_layer2.71630570
15MP0004381_abnormal_hair_follicle2.46984134
16MP0002060_abnormal_skin_morphology2.39279134
17MP0010771_integument_phenotype2.38491833
18MP0002234_abnormal_pharynx_morphology2.32345855
19MP0001243_abnormal_dermal_layer2.10338718
20MP0000367_abnormal_coat/_hair2.09191296
21MP0004947_skin_inflammation2.06165485
22MP0003453_abnormal_keratinocyte_physiol2.02332490
23MP0003941_abnormal_skin_development1.92067236
24MP0000762_abnormal_tongue_morphology1.80969734
25MP0000467_abnormal_esophagus_morphology1.75082050
26MP0009053_abnormal_anal_canal1.53834053
27MP0009931_abnormal_skin_appearance1.48409761
28MP0003566_abnormal_cell_adhesion1.28941469
29MP0001346_abnormal_lacrimal_gland1.10925939
30MP0001191_abnormal_skin_condition1.09262430
31MP0004885_abnormal_endolymph1.08020315
32MP0005409_darkened_coat_color1.05059698
33MP0003315_abnormal_perineum_morphology1.00698122
34MP0002249_abnormal_larynx_morphology0.99651660
35MP0004185_abnormal_adipocyte_glucose0.93628316
36MP0001851_eye_inflammation0.89056419
37MP0009379_abnormal_foot_pigmentation0.86384119
38MP0000566_synostosis0.85110306
39MP0000537_abnormal_urethra_morphology0.82242108
40MP0002095_abnormal_skin_pigmentation0.80294841
41MP0000678_abnormal_parathyroid_gland0.80129560
42MP0001340_abnormal_eyelid_morphology0.79782479
43MP0002282_abnormal_trachea_morphology0.77060919
44MP0003755_abnormal_palate_morphology0.74600327
45MP0010030_abnormal_orbit_morphology0.74533295
46MP0005367_renal/urinary_system_phenotyp0.73093966
47MP0000516_abnormal_urinary_system0.73093966
48MP0005451_abnormal_body_composition0.66586579
49MP0009384_cardiac_valve_regurgitation0.64417311
50MP0001879_abnormal_lymphatic_vessel0.63214439
51MP0001849_ear_inflammation0.60393491
52MP0004264_abnormal_extraembryonic_tissu0.60227454
53MP0008438_abnormal_cutaneous_collagen0.58566538
54MP0004272_abnormal_basement_membrane0.52302987
55MP0000627_abnormal_mammary_gland0.51371920
56MP0002009_preneoplasia0.51061634
57MP0002877_abnormal_melanocyte_morpholog0.50999474
58MP0002111_abnormal_tail_morphology0.50510231
59MP0001784_abnormal_fluid_regulation0.49444780
60MP0003385_abnormal_body_wall0.48632622
61MP0002177_abnormal_outer_ear0.46334843
62MP0004134_abnormal_chest_morphology0.45689440
63MP0009250_abnormal_appendicular_skeleto0.44940248
64MP0005023_abnormal_wound_healing0.44443430
65MP0010352_gastrointestinal_tract_polyps0.43436026
66MP0000465_gastrointestinal_hemorrhage0.41073988
67MP0005508_abnormal_skeleton_morphology0.40074568
68MP0003935_abnormal_craniofacial_develop0.38686117
69MP0002233_abnormal_nose_morphology0.38310923
70MP0003191_abnormal_cellular_cholesterol0.38028242
71MP0010368_abnormal_lymphatic_system0.38023914
72MP0005187_abnormal_penis_morphology0.36881866
73MP0000751_myopathy0.35577171
74MP0000432_abnormal_head_morphology0.35048204
75MP0000049_abnormal_middle_ear0.33357560
76MP0008789_abnormal_olfactory_epithelium0.32968924
77MP0000163_abnormal_cartilage_morphology0.32136041
78MP0002896_abnormal_bone_mineralization0.30124177
79MP0003763_abnormal_thymus_physiology0.27704572
80MP0005623_abnormal_meninges_morphology0.26907224
81MP0005394_taste/olfaction_phenotype0.26045446
82MP0005499_abnormal_olfactory_system0.26045446
83MP0001661_extended_life_span0.25996714
84MP0002115_abnormal_skeleton_extremities0.25986239
85MP0003950_abnormal_plasma_membrane0.24708400
86MP0003638_abnormal_response/metabolism_0.23777144
87MP0002970_abnormal_white_adipose0.20263159
88MP0002109_abnormal_limb_morphology0.20163601
89MP0003937_abnormal_limbs/digits/tail_de0.19564548
90MP0000428_abnormal_craniofacial_morphol0.18950153
91MP0000750_abnormal_muscle_regeneration0.17237366
92MP0006054_spinal_hemorrhage0.16711361
93MP0002697_abnormal_eye_size0.16331030
94MP0005503_abnormal_tendon_morphology0.16102840
95MP0003045_fibrosis0.14528491
96MP0004019_abnormal_vitamin_homeostasis0.13798823
97MP0006138_congestive_heart_failure0.13668911
98MP0001958_emphysema0.13439800
99MP0000733_abnormal_muscle_development0.13161425
100MP0002933_joint_inflammation0.12435628

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of hair growth rate (HP:0011363)8.85949261
2Slow-growing hair (HP:0002217)8.85949261
3Brittle hair (HP:0002299)8.81771286
4Pili torti (HP:0003777)8.29248747
5Nail dystrophy (HP:0008404)6.38151250
6Increased IgE level (HP:0003212)6.15897935
7Fragile nails (HP:0001808)5.59873422
8Abnormality of nail color (HP:0100643)5.54543413
9Onycholysis (HP:0001806)5.33196497
10Abnormal hair laboratory examination (HP:0003328)5.21053442
11Palmoplantar hyperkeratosis (HP:0000972)4.74029462
12Plantar hyperkeratosis (HP:0007556)4.56250299
13Palmar hyperkeratosis (HP:0010765)4.43479818
14Fine hair (HP:0002213)4.41218796
15Right ventricular cardiomyopathy (HP:0011663)4.34234563
16Alopecia of scalp (HP:0002293)4.25135503
17Thick nail (HP:0001805)3.81536090
18Erythema (HP:0010783)3.76865986
19Follicular hyperkeratosis (HP:0007502)3.71092232
20Sparse eyelashes (HP:0000653)3.66561025
21Erythroderma (HP:0001019)3.56656533
22Milia (HP:0001056)3.53075470
23Parakeratosis (HP:0001036)3.23928518
24Amelogenesis imperfecta (HP:0000705)3.18632633
25Congenital ichthyosiform erythroderma (HP:0007431)3.17342405
26Abnormality of the frontal sinuses (HP:0002687)3.07851432
27Congenital, generalized hypertrichosis (HP:0004540)3.06171960
28Oral leukoplakia (HP:0002745)2.81532451
29Ridged nail (HP:0001807)2.67941002
30Natal tooth (HP:0000695)2.64106103
31Curly hair (HP:0002212)2.51738464
32Aplasia cutis congenita (HP:0001057)2.50763411
33Concave nail (HP:0001598)2.48592159
34Advanced eruption of teeth (HP:0006288)2.46830032
35Abnormal blistering of the skin (HP:0008066)2.46231440
36Unilateral renal agenesis (HP:0000122)2.37810621
37Neck muscle weakness (HP:0000467)2.29372342
38Corneal erosion (HP:0200020)2.21068541
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.18102049
40Congenital malformation of the right heart (HP:0011723)2.17847408
41Double outlet right ventricle (HP:0001719)2.17847408
42Distal lower limb muscle weakness (HP:0009053)2.13332780
43Abnormality of the parietal bone (HP:0002696)2.12286705
44Conjunctival hamartoma (HP:0100780)2.12174509
45Hypohidrosis (HP:0000966)2.09218915
46Widely patent fontanelles and sutures (HP:0004492)2.08916769
47Pruritus (HP:0000989)2.06902123
48Dry hair (HP:0011359)2.06823151
49Abnormality of the aortic arch (HP:0012303)2.06630851
50Hyporeflexia of lower limbs (HP:0002600)2.05331764
51Ventricular tachycardia (HP:0004756)2.02233298
52Palmoplantar keratoderma (HP:0000982)2.01272590
53Hypotrichosis (HP:0001006)13.3477835
54Woolly hair (HP:0002224)10.3177692
55Acanthosis nigricans (HP:0000956)1.99097913
56Intention tremor (HP:0002080)1.96545393
57Lip pit (HP:0100267)1.94601269
58Increased connective tissue (HP:0009025)1.83065649
59Abnormality of molar (HP:0011077)1.82298318
60Abnormality of molar morphology (HP:0011070)1.82298318
61Type 1 muscle fiber predominance (HP:0003803)1.81486655
62Round ear (HP:0100830)1.80297126
63Abnormality of permanent molar morphology (HP:0011071)1.79729538
64Abnormality of the dental root (HP:0006486)1.79729538
65Taurodontia (HP:0000679)1.79729538
66Sparse scalp hair (HP:0002209)1.79443272
67Abnormality of dental color (HP:0011073)1.75245112
68Autoamputation (HP:0001218)1.71403432
69Torticollis (HP:0000473)1.69155572
70Hypergammaglobulinemia (HP:0010702)1.68120714
71Difficulty walking (HP:0002355)1.66015261
72Abnormality of the pupil (HP:0000615)1.65094845
73Blepharitis (HP:0000498)1.64971765
74Ventricular fibrillation (HP:0001663)1.61411609
75Down-sloping shoulders (HP:0200021)1.60495482
76Abnormality of the parathyroid morphology (HP:0011766)1.59891935
77Absent eyelashes (HP:0000561)1.58757637
78Abnormality of the neuromuscular junction (HP:0003398)1.58174313
79Fatigable weakness (HP:0003473)1.58174313
80Abnormality of the dental pulp (HP:0006479)1.56459447
81Gangrene (HP:0100758)1.55546968
82Abnormality of secondary sexual hair (HP:0009888)1.55069085
83Abnormality of the axillary hair (HP:0100134)1.55069085
84Hyperthyroidism (HP:0000836)1.51726163
85Atrophic scars (HP:0001075)1.51330680
86Ulnar deviation of the wrist (HP:0003049)1.46876101
87Distal arthrogryposis (HP:0005684)1.46858236
88Ectropion (HP:0000656)1.46275951
89Sudden death (HP:0001699)1.45364905
90Recurrent corneal erosions (HP:0000495)1.44301337
91Carious teeth (HP:0000670)1.43310586
92Bronchomalacia (HP:0002780)1.42197286
93Wide cranial sutures (HP:0010537)1.41158097
94Achilles tendon contracture (HP:0001771)1.39301417
95Craniofacial hyperostosis (HP:0004493)1.37224572
96Craniofacial dystonia (HP:0012179)1.35656757
97Neonatal short-limb short stature (HP:0008921)1.30947563
98Premature rupture of membranes (HP:0001788)1.30418900
99Abnormality of the Achilles tendon (HP:0005109)1.28227419
100Calcaneovalgus deformity (HP:0001848)1.27910073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB25.96144414
2MAP3K33.91977892
3MAPKAPK33.78565948
4EPHA23.45684531
5FER3.37609703
6MAP3K22.78515222
7MST42.75138661
8MAP3K62.64002909
9PIK3CG2.39872055
10ERN12.38778966
11ERBB32.38678014
12TTN2.32181146
13TAOK12.29104593
14TRPM72.11729822
15BCR2.05422206
16LATS11.89999997
17STK241.63560811
18RPS6KB21.62683584
19FGFR21.59733467
20OBSCN1.49918926
21NME11.44745680
22MST1R1.41579410
23MAP2K61.38180716
24LRRK21.34504856
25MAP3K111.33448179
26MAP3K11.26192670
27PTK61.20392834
28TRIB31.19473786
29PBK1.16833617
30TGFBR11.16672406
31LATS21.12666398
32DDR21.12053831
33BMPR1B1.03495825
34EPHB11.02340017
35CDK61.01851852
36FGFR11.01514808
37MAP2K30.98352887
38MAP3K70.97004756
39PIM20.96254423
40KSR20.92009149
41PRKD10.90047940
42MAPKAPK20.89358217
43DYRK1B0.88564554
44STK38L0.81753169
45TNK20.79823397
46EEF2K0.79070081
47FGFR30.76870039
48ERBB40.76656951
49MAP2K10.75785423
50FGFR40.74931312
51BMX0.72894317
52BLK0.70401906
53MET0.70091642
54MAPKAPK50.64354229
55PTK20.63247118
56NTRK20.62143254
57PRKCI0.61671908
58PHKG20.60128999
59PHKG10.60128999
60MAP3K90.57590903
61PDGFRA0.55915796
62MAP2K20.55513443
63GSK3A0.53830974
64RPS6KA40.50688198
65PAK30.49274463
66STK100.47111966
67PIK3CA0.44603470
68HIPK20.44306024
69CLK10.40398282
70MAPK120.39122557
71RIPK10.38442330
72RET0.37969869
73TGFBR20.36612055
74ROCK10.35578973
75MAP3K50.35573788
76RPS6KA10.35386391
77ERBB20.35030867
78CDK190.34170741
79PRKACA0.32803612
80MAP2K40.32452321
81PKN10.32426468
82PRKCH0.32404742
83PKN20.32008574
84PRKACG0.31524800
85EPHA30.31402602
86JAK20.30186166
87EPHA40.28168517
88CSNK1E0.25369249
89ROCK20.24810595
90HCK0.24159073
91ADRBK10.24087606
92CSNK1D0.23822194
93PAK20.23442637
94STK380.22947028
95STK110.22521015
96SRC0.22056722
97CSNK1G20.21844823
98TESK10.20340669
99PRKCA0.19616901
100SGK10.19199120

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.51469064
2Linoleic acid metabolism_Homo sapiens_hsa005913.51424437
3Basal cell carcinoma_Homo sapiens_hsa052173.34881347
4Fatty acid elongation_Homo sapiens_hsa000622.86031965
5Fat digestion and absorption_Homo sapiens_hsa049752.39265783
6Hedgehog signaling pathway_Homo sapiens_hsa043402.29686914
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.13746211
8Melanogenesis_Homo sapiens_hsa049162.10898995
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.10071253
10Ether lipid metabolism_Homo sapiens_hsa005651.95519578
11ECM-receptor interaction_Homo sapiens_hsa045121.91208918
12Axon guidance_Homo sapiens_hsa043601.81903836
13Phenylalanine metabolism_Homo sapiens_hsa003601.80206312
14Arachidonic acid metabolism_Homo sapiens_hsa005901.72484278
15Hippo signaling pathway_Homo sapiens_hsa043901.72110023
16Proteoglycans in cancer_Homo sapiens_hsa052051.52649157
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46729446
18TGF-beta signaling pathway_Homo sapiens_hsa043501.40650319
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.38827871
20VEGF signaling pathway_Homo sapiens_hsa043701.34871196
21Histidine metabolism_Homo sapiens_hsa003401.34810633
22Ribosome_Homo sapiens_hsa030101.33329717
23Adherens junction_Homo sapiens_hsa045201.33229750
24Bladder cancer_Homo sapiens_hsa052191.32960989
25Phototransduction_Homo sapiens_hsa047441.30328321
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.29024498
27Protein digestion and absorption_Homo sapiens_hsa049741.26740429
28Sphingolipid metabolism_Homo sapiens_hsa006001.26729308
29Tight junction_Homo sapiens_hsa045301.23967920
30Wnt signaling pathway_Homo sapiens_hsa043101.18629172
31GnRH signaling pathway_Homo sapiens_hsa049121.16250404
32Renin secretion_Homo sapiens_hsa049241.14935149
33Salivary secretion_Homo sapiens_hsa049701.13960684
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07912481
35Mineral absorption_Homo sapiens_hsa049781.07187446
36Thyroid cancer_Homo sapiens_hsa052161.06358009
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05013185
38Glioma_Homo sapiens_hsa052141.04408730
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02696812
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01986507
41Gastric acid secretion_Homo sapiens_hsa049710.99378408
42Pancreatic secretion_Homo sapiens_hsa049720.99283817
43Tyrosine metabolism_Homo sapiens_hsa003500.96497402
44Ras signaling pathway_Homo sapiens_hsa040140.92170504
45Chemical carcinogenesis_Homo sapiens_hsa052040.91992300
46Long-term potentiation_Homo sapiens_hsa047200.91879758
47Dorso-ventral axis formation_Homo sapiens_hsa043200.88393509
48Amoebiasis_Homo sapiens_hsa051460.87685973
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87146336
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.86838964
51Pertussis_Homo sapiens_hsa051330.86241717
52Steroid biosynthesis_Homo sapiens_hsa001000.82622755
53PPAR signaling pathway_Homo sapiens_hsa033200.81079924
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80490972
55Long-term depression_Homo sapiens_hsa047300.78556334
56Focal adhesion_Homo sapiens_hsa045100.77706960
57Estrogen signaling pathway_Homo sapiens_hsa049150.74574338
58Olfactory transduction_Homo sapiens_hsa047400.73446657
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.69630528
60Rap1 signaling pathway_Homo sapiens_hsa040150.68898264
61Oxytocin signaling pathway_Homo sapiens_hsa049210.68095024
62Acute myeloid leukemia_Homo sapiens_hsa052210.64868741
63MicroRNAs in cancer_Homo sapiens_hsa052060.63083439
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62641378
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61062848
66Staphylococcus aureus infection_Homo sapiens_hsa051500.60080844
67Melanoma_Homo sapiens_hsa052180.59358841
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59029496
69beta-Alanine metabolism_Homo sapiens_hsa004100.58961088
70Endometrial cancer_Homo sapiens_hsa052130.58277250
71Caffeine metabolism_Homo sapiens_hsa002320.55110425
72Dilated cardiomyopathy_Homo sapiens_hsa054140.54432458
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54290574
74Platelet activation_Homo sapiens_hsa046110.54165828
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54089673
76Fatty acid biosynthesis_Homo sapiens_hsa000610.53092616
77Retinol metabolism_Homo sapiens_hsa008300.51767378
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50925300
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49606203
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49068579
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.48373624
82Fatty acid metabolism_Homo sapiens_hsa012120.46975589
83Gap junction_Homo sapiens_hsa045400.46509868
84Pathways in cancer_Homo sapiens_hsa052000.45809402
85Non-small cell lung cancer_Homo sapiens_hsa052230.45322687
86Circadian entrainment_Homo sapiens_hsa047130.44171088
87Calcium signaling pathway_Homo sapiens_hsa040200.40119139
88Notch signaling pathway_Homo sapiens_hsa043300.40019728
89Hepatitis C_Homo sapiens_hsa051600.37769756
90Salmonella infection_Homo sapiens_hsa051320.36810632
91p53 signaling pathway_Homo sapiens_hsa041150.36192362
92Glutathione metabolism_Homo sapiens_hsa004800.35521413
93Insulin resistance_Homo sapiens_hsa049310.34954732
94Fatty acid degradation_Homo sapiens_hsa000710.34910380
95Nitrogen metabolism_Homo sapiens_hsa009100.34567861
96Amphetamine addiction_Homo sapiens_hsa050310.34355560
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33973767
98Dopaminergic synapse_Homo sapiens_hsa047280.33695549
99Complement and coagulation cascades_Homo sapiens_hsa046100.31599918
100cAMP signaling pathway_Homo sapiens_hsa040240.31495314

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