KRT33B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)9.95165821
2virion attachment to host cell (GO:0019062)9.95165821
3peptide cross-linking (GO:0018149)8.99966897
4citrulline biosynthetic process (GO:0019240)8.93832592
5hair follicle morphogenesis (GO:0031069)8.55812780
6adhesion of symbiont to host (GO:0044406)8.38232825
7establishment of skin barrier (GO:0061436)7.29533065
8intermediate filament cytoskeleton organization (GO:0045104)6.91552532
9intermediate filament-based process (GO:0045103)6.69366774
10cell wall macromolecule catabolic process (GO:0016998)6.65477495
11cell wall macromolecule metabolic process (GO:0044036)6.65477495
12epidermis development (GO:0008544)6.61531034
13regulation of water loss via skin (GO:0033561)6.41999057
14keratinocyte differentiation (GO:0030216)6.29595701
15linoleic acid metabolic process (GO:0043651)5.97688876
16citrulline metabolic process (GO:0000052)5.90209474
17hair cycle process (GO:0022405)5.56261466
18molting cycle process (GO:0022404)5.56261466
19long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.42079817
20bundle of His cell to Purkinje myocyte communication (GO:0086069)5.28715037
21skin morphogenesis (GO:0043589)5.21493861
22fatty-acyl-CoA biosynthetic process (GO:0046949)5.16075797
23hemidesmosome assembly (GO:0031581)5.14555340
24peptidyl-arginine modification (GO:0018195)4.93680579
25epidermal cell differentiation (GO:0009913)4.90764122
26retinol metabolic process (GO:0042572)4.86233779
27multicellular organismal water homeostasis (GO:0050891)4.29140926
28fatty-acyl-CoA metabolic process (GO:0035337)4.27285117
29thioester biosynthetic process (GO:0035384)4.17919492
30acyl-CoA biosynthetic process (GO:0071616)4.17919492
31tooth mineralization (GO:0034505)4.13362382
32keratinocyte development (GO:0003334)4.10230134
33* hair cycle (GO:0042633)32.2370318
34* molting cycle (GO:0042303)32.2370318
35regulation of keratinocyte differentiation (GO:0045616)3.54096011
36water homeostasis (GO:0030104)3.52450337
37phosphatidylinositol acyl-chain remodeling (GO:0036149)3.51682670
38negative regulation of keratinocyte proliferation (GO:0010839)3.50004168
39primary alcohol metabolic process (GO:0034308)3.40929112
40positive regulation of hair cycle (GO:0042635)3.40393983
41positive regulation of hair follicle development (GO:0051798)3.40393983
42alpha-linolenic acid metabolic process (GO:0036109)3.38556349
43positive regulation of keratinocyte differentiation (GO:0045618)3.36011239
44hair follicle development (GO:0001942)3.35144427
45long-chain fatty acid biosynthetic process (GO:0042759)3.29600389
46phosphatidylserine acyl-chain remodeling (GO:0036150)3.21489108
47regulation of hair follicle development (GO:0051797)3.18026607
48negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.16936502
49bone trabecula formation (GO:0060346)3.16684371
50epithelium development (GO:0060429)3.13398755
51regulation of sequestering of triglyceride (GO:0010889)3.10695227
52triglyceride biosynthetic process (GO:0019432)3.00970891
53defense response to fungus (GO:0050832)3.00376648
54positive regulation of chemokine secretion (GO:0090197)2.98795104
55positive regulation of meiotic cell cycle (GO:0051446)2.98503234
56phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.93688421
57fatty acid elongation (GO:0030497)2.92807488
58gap junction assembly (GO:0016264)2.90681919
59regulation of hair cycle (GO:0042634)2.86439511
60positive regulation of epidermis development (GO:0045684)2.85377125
61acylglycerol biosynthetic process (GO:0046463)2.83575178
62neutral lipid biosynthetic process (GO:0046460)2.83575178
63ectoderm development (GO:0007398)2.82315417
64disruption of cells of other organism (GO:0044364)2.76789140
65killing of cells of other organism (GO:0031640)2.76789140
66regulation of chemokine secretion (GO:0090196)2.74722374
67regulation of epidermal cell differentiation (GO:0045604)2.73576698
68atrioventricular valve morphogenesis (GO:0003181)2.71891078
69regulation of epidermis development (GO:0045682)2.63374081
70negative regulation of protein localization to plasma membrane (GO:1903077)2.62473117
71lipoxygenase pathway (GO:0019372)2.60388069
72epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.57506909
73thioester metabolic process (GO:0035383)2.47757806
74acyl-CoA metabolic process (GO:0006637)2.47757806
75ventricular cardiac muscle cell action potential (GO:0086005)2.45002355
76phosphatidylserine metabolic process (GO:0006658)2.42772529
77negative regulation of cell fate specification (GO:0009996)2.42729604
78regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.41392633
79skin development (GO:0043588)2.39383941
80wound healing, spreading of epidermal cells (GO:0035313)2.37558448
81cell surface receptor signaling pathway involved in heart development (GO:0061311)2.36780562
82positive regulation of monocyte chemotaxis (GO:0090026)2.36537408
83phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.35544413
84regulation of mesenchymal cell apoptotic process (GO:2001053)2.35522454
85positive regulation of epidermal cell differentiation (GO:0045606)2.33045960
86lymph vessel development (GO:0001945)2.29686124
87cranial suture morphogenesis (GO:0060363)2.29385511
88carnitine metabolic process (GO:0009437)2.28658877
89regulation of ruffle assembly (GO:1900027)2.21540247
90fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.19807518
91myotube differentiation (GO:0014902)2.17945507
92regulation of cardioblast differentiation (GO:0051890)2.12973773
93epithelial cell-cell adhesion (GO:0090136)2.12446273
94negative regulation of epidermis development (GO:0045683)2.08998319
95planar cell polarity pathway involved in neural tube closure (GO:0090179)2.08207567
96outflow tract septum morphogenesis (GO:0003148)2.07798796
97phosphatidylcholine acyl-chain remodeling (GO:0036151)2.07734501
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.05711420
99response to phenylpropanoid (GO:0080184)2.04763651
100regulation of heart rate by cardiac conduction (GO:0086091)2.04200229
101regulation of defense response to virus by host (GO:0050691)2.01227610
102keratinization (GO:0031424)13.3946648
103intermediate filament organization (GO:0045109)12.5004945
104desmosome organization (GO:0002934)10.7073663
105ephrin receptor signaling pathway (GO:0048013)1.99725155
106regulation of keratinocyte proliferation (GO:0010837)1.97742693
107keratinocyte proliferation (GO:0043616)1.97041719
108phosphatidic acid metabolic process (GO:0046473)1.96069159
109phosphatidic acid biosynthetic process (GO:0006654)1.96069159
110non-canonical Wnt signaling pathway (GO:0035567)1.95644358
111regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.94899183
112cell communication involved in cardiac conduction (GO:0086065)1.93164175
113negative regulation of fatty acid transport (GO:2000192)1.92157649
114fatty acid biosynthetic process (GO:0006633)1.92048060
115regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.91515362
116one-carbon compound transport (GO:0019755)1.90652763
117cell-substrate junction assembly (GO:0007044)1.89080593
118response to fungus (GO:0009620)1.85144361
119primary alcohol catabolic process (GO:0034310)1.82409159
120regulation of phospholipase A2 activity (GO:0032429)1.81036241
121very long-chain fatty acid metabolic process (GO:0000038)1.80075101
122negative regulation of execution phase of apoptosis (GO:1900118)1.79721202
123alditol phosphate metabolic process (GO:0052646)1.78747273
124coronary vasculature morphogenesis (GO:0060977)1.77983004
125regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.77275171
126regulation of secondary heart field cardioblast proliferation (GO:0003266)1.76388300
127regulation of cardioblast proliferation (GO:0003264)1.76388300
128ethanol metabolic process (GO:0006067)1.75815002
129unsaturated fatty acid biosynthetic process (GO:0006636)1.75448373
130establishment of planar polarity (GO:0001736)1.75218489
131establishment of tissue polarity (GO:0007164)1.75218489
132long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.71263897
133* aging (GO:0007568)1.70691867
134cardiac right ventricle morphogenesis (GO:0003215)1.70611609
135regulation of monocyte chemotaxis (GO:0090025)1.69955182
136sphingoid metabolic process (GO:0046519)1.69233765
137negative regulation of cell fate commitment (GO:0010454)1.67980837
138wound healing, spreading of cells (GO:0044319)1.66781351
139negative regulation of epidermal cell differentiation (GO:0045605)1.66388144
140regulation of apoptotic process involved in morphogenesis (GO:1902337)1.63254292
141retinoid metabolic process (GO:0001523)1.60680004
142lateral sprouting from an epithelium (GO:0060601)1.58851118
143amino-acid betaine metabolic process (GO:0006577)1.56941640

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.56375548
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.87992545
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.48457258
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.73766346
5CTCF_20526341_ChIP-Seq_ESCs_Human2.37500108
6BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.06262574
7NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.05690848
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.5877879
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.83543573
10TAF2_19829295_ChIP-Seq_ESCs_Human1.82759333
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.77271053
12SOX9_24532713_ChIP-Seq_HFSC_Mouse1.74898408
13ERG_20517297_ChIP-Seq_VCAP_Human1.71955347
14EGR1_19032775_ChIP-ChIP_M12_Human1.71293899
15NANOG_20526341_ChIP-Seq_ESCs_Human1.70510761
16* E2F1_20622854_ChIP-Seq_HELA_Human1.68178729
17CTCF_27219007_Chip-Seq_Bcells_Human1.63516095
18* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.61587143
19P53_21459846_ChIP-Seq_SAOS-2_Human1.60578515
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.55996587
21* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.55427438
22BCL6_27268052_Chip-Seq_Bcells_Human1.54500636
23YY1_22570637_ChIP-Seq_MALME-3M_Human1.53543667
24TP53_20018659_ChIP-ChIP_R1E_Mouse1.53492597
25RACK7_27058665_Chip-Seq_MCF-7_Human1.51923578
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.49255596
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.49255596
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47869306
29LXR_22292898_ChIP-Seq_THP-1_Human1.47352895
30BCOR_27268052_Chip-Seq_Bcells_Human1.46772263
31* TP63_22573176_ChIP-Seq_HFKS_Human1.44517584
32MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.41151798
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40415560
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38853133
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.38767113
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36692376
37ATF3_27146783_Chip-Seq_COLON_Human1.36253863
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34842326
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34343974
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26926117
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.26693699
42PHF8_20622854_ChIP-Seq_HELA_Human1.26105503
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.24842358
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.24716052
45AHR_22903824_ChIP-Seq_MCF-7_Human1.22952982
46CEBPB_22108803_ChIP-Seq_LS180_Human1.21164429
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21158329
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20469526
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.18591023
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17465602
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17268418
52TP63_23658742_ChIP-Seq_EP156T_Human1.14959074
53ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13533603
54* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12668576
55E2F1_17053090_ChIP-ChIP_MCF-7_Human1.12250476
56GATA3_24758297_ChIP-Seq_MCF-7_Human1.11968618
57RAC3_21632823_ChIP-Seq_H3396_Human1.11374184
58* P68_20966046_ChIP-Seq_HELA_Human1.08545957
59SMC4_20622854_ChIP-Seq_HELA_Human1.08022398
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.06834792
61TP53_16413492_ChIP-PET_HCT116_Human1.06469748
62GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06430770
63JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05884108
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05676769
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.05618716
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05454324
67SOX2_21211035_ChIP-Seq_LN229_Human1.04982279
68GATA4_25053715_ChIP-Seq_YYC3_Human1.04819652
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03865970
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03738573
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03568295
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.01103669
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00050910
74SPI1_20517297_ChIP-Seq_HL60_Human0.99760379
75TP53_18474530_ChIP-ChIP_U2OS_Human0.99134091
76GATA6_21074721_ChIP-Seq_CACO-2_Human0.97273187
77KLF5_25053715_ChIP-Seq_YYC3_Human0.97209132
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96799004
79ZNF263_19887448_ChIP-Seq_K562_Human0.96693942
80FOXH1_21741376_ChIP-Seq_ESCs_Human0.95642131
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95541527
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92352366
83ERG_21242973_ChIP-ChIP_JURKAT_Human0.91401227
84RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90702157
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90387759
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89967750
87RXR_22108803_ChIP-Seq_LS180_Human0.89929821
88RUNX1_27514584_Chip-Seq_MCF-7_Human0.89554008
89RING1B_27294783_Chip-Seq_ESCs_Mouse0.89419562
90ESR1_20079471_ChIP-ChIP_T-47D_Human0.89129521
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87056522
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86606721
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83000330
94NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83000330
95SOX2_20726797_ChIP-Seq_SW620_Human0.82314395
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.82291946
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81772225
98RNF2_27304074_Chip-Seq_ESCs_Mouse0.81668549
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81349388
100AR_21572438_ChIP-Seq_LNCaP_Human0.80896638
101EZH2_27294783_Chip-Seq_ESCs_Mouse0.80204361
102BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79774159
103ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79468429
104CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.78324884
105ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77628444
106EZH2_27304074_Chip-Seq_ESCs_Mouse0.77578673
107CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77101310
108SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.74614073
109PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.74338444
110GATA3_21878914_ChIP-Seq_MCF-7_Human0.74202618
111HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74052535
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.73514323
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73075754
114FOXA1_25329375_ChIP-Seq_VCAP_Human0.72887431
115FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72887431
116CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.72584813
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71876721
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71876721
119SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.71015000
120HNFA_21074721_ChIP-Seq_CACO-2_Human0.68799028
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.68326892
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.68326892
123PHF8_20622853_ChIP-Seq_HELA_Human0.68261628
124EZH2_18974828_ChIP-Seq_MESCs_Mouse0.67864421
125RNF2_18974828_ChIP-Seq_MESCs_Mouse0.67864421
126CJUN_26792858_Chip-Seq_BT549_Human0.67617223
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.64554412

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.38658813
2MP0002098_abnormal_vibrissa_morphology7.00990064
3MP0000647_abnormal_sebaceous_gland6.32910875
4MP0002796_impaired_skin_barrier6.25239779
5MP0005275_abnormal_skin_tensile5.39045155
6MP0010234_abnormal_vibrissa_follicle5.07514920
7MP0000383_abnormal_hair_follicle4.42085327
8MP0000377_abnormal_hair_follicle4.00773019
9MP0010678_abnormal_skin_adnexa3.92524271
10MP0005501_abnormal_skin_physiology3.88856203
11MP0003705_abnormal_hypodermis_morpholog3.74719345
12MP0000427_abnormal_hair_cycle3.44903603
13MP0002254_reproductive_system_inflammat3.11682278
14MP0001216_abnormal_epidermal_layer2.73648661
15MP0004381_abnormal_hair_follicle2.47783396
16MP0010771_integument_phenotype2.40056352
17MP0004947_skin_inflammation2.36777459
18MP0000367_abnormal_coat/_hair2.34883910
19MP0002060_abnormal_skin_morphology2.29337831
20MP0005377_hearing/vestibular/ear_phenot2.19617881
21MP0003878_abnormal_ear_physiology2.19617881
22MP0001243_abnormal_dermal_layer2.16292357
23MP0003453_abnormal_keratinocyte_physiol2.14101448
24MP0002234_abnormal_pharynx_morphology2.01978307
25MP0000467_abnormal_esophagus_morphology1.69891882
26MP0009931_abnormal_skin_appearance1.55057407
27MP0009053_abnormal_anal_canal1.50074060
28MP0000762_abnormal_tongue_morphology1.47911639
29MP0003566_abnormal_cell_adhesion1.42667788
30MP0003941_abnormal_skin_development1.34601954
31MP0005409_darkened_coat_color1.16336759
32MP0001191_abnormal_skin_condition1.03844966
33MP0004185_abnormal_adipocyte_glucose0.97894558
34MP0004885_abnormal_endolymph0.92546138
35MP0002095_abnormal_skin_pigmentation0.90505611
36MP0005503_abnormal_tendon_morphology0.87613798
37MP0008438_abnormal_cutaneous_collagen0.86085208
38MP0004264_abnormal_extraembryonic_tissu0.85588083
39MP0005647_abnormal_sex_gland0.78681202
40MP0006035_abnormal_mitochondrial_morpho0.78162340
41MP0001851_eye_inflammation0.76669801
42MP0010030_abnormal_orbit_morphology0.70404700
43MP0000015_abnormal_ear_pigmentation0.69916078
44MP0001346_abnormal_lacrimal_gland0.69599377
45MP0003315_abnormal_perineum_morphology0.68917331
46MP0001340_abnormal_eyelid_morphology0.65876001
47MP0001849_ear_inflammation0.64974906
48MP0005174_abnormal_tail_pigmentation0.64888333
49MP0002877_abnormal_melanocyte_morpholog0.62868897
50MP0000566_synostosis0.62364931
51MP0005451_abnormal_body_composition0.61475956
52MP0003191_abnormal_cellular_cholesterol0.59379134
53MP0000627_abnormal_mammary_gland0.56229955
54MP0009780_abnormal_chondrocyte_physiolo0.54117222
55MP0001661_extended_life_span0.50192625
56MP0002282_abnormal_trachea_morphology0.49974176
57MP0003755_abnormal_palate_morphology0.49015036
58MP0010386_abnormal_urinary_bladder0.48968667
59MP0001784_abnormal_fluid_regulation0.48734960
60MP0001485_abnormal_pinna_reflex0.48717067
61MP0009379_abnormal_foot_pigmentation0.47915801
62MP0005023_abnormal_wound_healing0.46791269
63MP0002970_abnormal_white_adipose0.42953075
64MP0002111_abnormal_tail_morphology0.41914323
65MP0003279_aneurysm0.39685293
66MP0002249_abnormal_larynx_morphology0.39322370
67MP0002177_abnormal_outer_ear0.37408376
68MP0005083_abnormal_biliary_tract0.36839610
69MP0010352_gastrointestinal_tract_polyps0.34262555
70MP0005075_abnormal_melanosome_morpholog0.33622858
71MP0003385_abnormal_body_wall0.33539834
72MP0000537_abnormal_urethra_morphology0.32589151
73MP0000678_abnormal_parathyroid_gland0.31065775
74MP0004272_abnormal_basement_membrane0.30827596
75MP0005508_abnormal_skeleton_morphology0.30057891
76MP0001542_abnormal_bone_strength0.28114365
77MP0009840_abnormal_foam_cell0.26657881
78MP0001984_abnormal_olfaction0.25372369
79MP0003950_abnormal_plasma_membrane0.25027994
80MP0001905_abnormal_dopamine_level0.24622450
81MP0000465_gastrointestinal_hemorrhage0.24603668
82MP0003763_abnormal_thymus_physiology0.24550596
83MP0002697_abnormal_eye_size0.24425351
84MP0005248_abnormal_Harderian_gland0.24193497
85MP0003329_amyloid_beta_deposits0.23608314
86MP0005535_abnormal_body_temperature0.22502333
87MP0010368_abnormal_lymphatic_system0.22013239
88MP0006054_spinal_hemorrhage0.20728203
89MP0005452_abnormal_adipose_tissue0.20005837
90MP0000432_abnormal_head_morphology0.19430260
91MP0005257_abnormal_intraocular_pressure0.18932489
92MP0005666_abnormal_adipose_tissue0.18519965
93MP0001188_hyperpigmentation0.17772941
94MP0004019_abnormal_vitamin_homeostasis0.17428345
95MP0000751_myopathy0.17269149
96MP0001879_abnormal_lymphatic_vessel0.17066491
97MP0003300_gastrointestinal_ulcer0.15958194
98MP0005197_abnormal_uvea_morphology0.15856977
99MP0003935_abnormal_craniofacial_develop0.15610195
100MP0005375_adipose_tissue_phenotype0.14712128
101MP0004742_abnormal_vestibular_system0.14655434
102MP0000358_abnormal_cell_content/0.14634064
103MP0003448_altered_tumor_morphology0.13735123
104MP0004782_abnormal_surfactant_physiolog0.13516052
105MP0003638_abnormal_response/metabolism_0.13325792
106MP0004858_abnormal_nervous_system0.12900737
107MP0005076_abnormal_cell_differentiation0.12559751
108MP0005367_renal/urinary_system_phenotyp0.12169751
109MP0000516_abnormal_urinary_system0.12169751
110MP0002163_abnormal_gland_morphology0.12122655
111MP0001881_abnormal_mammary_gland0.11871151
112MP0002896_abnormal_bone_mineralization0.11820832
113MP0003091_abnormal_cell_migration0.11685672
114MP0003011_delayed_dark_adaptation0.11507047
115MP0000604_amyloidosis0.11385476
116MP0002233_abnormal_nose_morphology0.11347747
117MP0000733_abnormal_muscle_development0.11204411
118MP0002166_altered_tumor_susceptibility0.11161865
119MP0002006_tumorigenesis0.10399766
120MP0001958_emphysema0.09803059
121MP0003045_fibrosis0.08449921
122MP0000538_abnormal_urinary_bladder0.08426502
123MP0009384_cardiac_valve_regurgitation0.08343766
124MP0005193_abnormal_anterior_eye0.08294213
125MP0003075_altered_response_to0.08113482
126MP0000013_abnormal_adipose_tissue0.07012770
127MP0000462_abnormal_digestive_system0.06910502
128MP0000428_abnormal_craniofacial_morphol0.06809216
129MP0005085_abnormal_gallbladder_physiolo0.05505174
130MP0005379_endocrine/exocrine_gland_phen0.05348136
131MP0005595_abnormal_vascular_smooth0.04770892
132MP0002971_abnormal_brown_adipose0.03936278
133MP0006072_abnormal_retinal_apoptosis0.03697244
134MP0002108_abnormal_muscle_morphology0.02169643

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)8.67567391
2Nail dystrophy (HP:0008404)7.41925474
3Absent eyebrow (HP:0002223)6.25224211
4Abnormality of nail color (HP:0100643)6.01582017
5Fragile nails (HP:0001808)5.48520840
6Abnormal hair laboratory examination (HP:0003328)5.46905040
7Absent hair (HP:0002298)5.33444325
8Fine hair (HP:0002213)5.25233187
9Increased IgE level (HP:0003212)4.94481607
10Palmoplantar hyperkeratosis (HP:0000972)4.92394483
11Alopecia of scalp (HP:0002293)4.77927234
12Onycholysis (HP:0001806)4.72338723
13Palmar hyperkeratosis (HP:0010765)4.63331392
14Plantar hyperkeratosis (HP:0007556)4.47815079
15Thick nail (HP:0001805)4.27632482
16Right ventricular cardiomyopathy (HP:0011663)4.11116358
17Follicular hyperkeratosis (HP:0007502)4.04534882
18Abnormality of secondary sexual hair (HP:0009888)3.75432999
19Abnormality of the axillary hair (HP:0100134)3.75432999
20Erythema (HP:0010783)3.69797157
21Sparse eyelashes (HP:0000653)3.42586192
22Erythroderma (HP:0001019)3.29250767
23Oral leukoplakia (HP:0002745)3.19659852
24Milia (HP:0001056)3.14113042
25Abnormality of the frontal sinuses (HP:0002687)3.09026770
26Amelogenesis imperfecta (HP:0000705)3.01429062
27Parakeratosis (HP:0001036)2.94457418
28Congenital ichthyosiform erythroderma (HP:0007431)2.82003574
29Curly hair (HP:0002212)2.69500011
30Ridged nail (HP:0001807)2.58867502
31Congenital, generalized hypertrichosis (HP:0004540)2.48024829
32Intention tremor (HP:0002080)2.44728342
33Aplasia cutis congenita (HP:0001057)2.44420634
34Abnormal blistering of the skin (HP:0008066)2.43832219
35Neck muscle weakness (HP:0000467)2.41499576
36Dry hair (HP:0011359)2.35361023
37Conjunctival hamartoma (HP:0100780)2.32364223
38Natal tooth (HP:0000695)2.30817397
39Advanced eruption of teeth (HP:0006288)2.25036977
40Corneal erosion (HP:0200020)2.19604271
41Torticollis (HP:0000473)2.18591534
42Hypohidrosis (HP:0000966)2.13318537
43Palmoplantar keratoderma (HP:0000982)2.09643327
44Coarse hair (HP:0002208)2.05005738
45Hypotrichosis (HP:0001006)15.0410181
46Slow-growing hair (HP:0002217)11.1310078
47Abnormality of hair growth rate (HP:0011363)11.1310078
48Woolly hair (HP:0002224)10.7485344
49Brittle hair (HP:0002299)10.4614094
50Ventricular tachycardia (HP:0004756)1.98234079
51Pruritus (HP:0000989)1.92276555
52Craniofacial dystonia (HP:0012179)1.84367999
53Concave nail (HP:0001598)1.84098088
54Difficulty walking (HP:0002355)1.79997707
55Abnormality of the parietal bone (HP:0002696)1.76274672
56Abnormality of the pupil (HP:0000615)1.75766226
57Hyporeflexia of lower limbs (HP:0002600)1.72513145
58Abnormality of the dental root (HP:0006486)1.71772053
59Taurodontia (HP:0000679)1.71772053
60Abnormality of permanent molar morphology (HP:0011071)1.71772053
61Abnormality of dental color (HP:0011073)1.71449695
62Abnormality of molar (HP:0011077)1.69771034
63Abnormality of molar morphology (HP:0011070)1.69771034
64Ventricular fibrillation (HP:0001663)1.69428269
65Focal dystonia (HP:0004373)1.68371917
66Widely patent fontanelles and sutures (HP:0004492)1.65890904
67Absent eyelashes (HP:0000561)1.61621533
68Gangrene (HP:0100758)1.59672428
69Recurrent corneal erosions (HP:0000495)1.57095288
70Abnormality of the neuromuscular junction (HP:0003398)1.56945483
71Fatigable weakness (HP:0003473)1.56945483
72Blepharitis (HP:0000498)1.54610920
73Unilateral renal agenesis (HP:0000122)1.50900306
74Abnormality of the dental pulp (HP:0006479)1.49753225
75Sudden death (HP:0001699)1.49301896
76Round ear (HP:0100830)1.49112261
77Furrowed tongue (HP:0000221)1.46849461
78Abnormality of the aortic arch (HP:0012303)1.46773253
79Hamartoma of the eye (HP:0010568)1.46690522
80Acanthosis nigricans (HP:0000956)1.46662684
81Lip pit (HP:0100267)1.46626340
82Ectropion (HP:0000656)1.46267320
83Distal lower limb muscle weakness (HP:0009053)1.44861426
84Abnormality of placental membranes (HP:0011409)1.44639214
85Amniotic constriction ring (HP:0009775)1.44639214
86Hypergammaglobulinemia (HP:0010702)1.43079318
87Heterogeneous (HP:0001425)1.43069027
88Type 1 muscle fiber predominance (HP:0003803)1.41345593
89Achilles tendon contracture (HP:0001771)1.40301349
90Keratoconjunctivitis sicca (HP:0001097)1.36580875
91Carious teeth (HP:0000670)1.34923098
92Neonatal short-limb short stature (HP:0008921)1.33077877
93Increased connective tissue (HP:0009025)1.32618463
94Abnormality of the Achilles tendon (HP:0005109)1.31655963
95Atrophic scars (HP:0001075)1.30177895
96Craniofacial hyperostosis (HP:0004493)1.28501760
97Anonychia (HP:0001798)1.28189151
98Multifactorial inheritance (HP:0001426)1.26976531
99Autoamputation (HP:0001218)1.26809301
100Abnormality of the fingernails (HP:0001231)1.26044903
101Lack of skin elasticity (HP:0100679)1.24835591
102Variable expressivity (HP:0003828)1.22396113
103Urticaria (HP:0001025)1.22212860
104Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.22080680
105Keratoconjunctivitis (HP:0001096)1.20050270
106Neonatal onset (HP:0003623)1.18405802
107Distal arthrogryposis (HP:0005684)1.16729920
108Premature rupture of membranes (HP:0001788)1.16531351
109Sparse scalp hair (HP:0002209)1.16165099
110Selective tooth agenesis (HP:0001592)1.14492645
111Protrusio acetabuli (HP:0003179)1.05256694
112Cranial hyperostosis (HP:0004437)1.03480108
113Hypoplastic toenails (HP:0001800)1.00742539
114Laryngomalacia (HP:0001601)0.94930921
115Hyperhidrosis (HP:0000975)0.94297523
116Abnormality of the salivary glands (HP:0010286)0.88985367
117Aplasia involving bones of the upper limbs (HP:0009823)0.87278423
118Aplasia of the phalanges of the hand (HP:0009802)0.87278423
119Aplasia involving bones of the extremities (HP:0009825)0.87278423
120Generalized hyperpigmentation (HP:0007440)0.85022577
121Xerostomia (HP:0000217)0.83192735
122Bladder diverticulum (HP:0000015)0.82142437
123Conical tooth (HP:0000698)0.82090400
124Corneal dystrophy (HP:0001131)0.79898154
125Skin ulcer (HP:0200042)0.79819591
126Melanocytic nevus (HP:0000995)0.78305695
127Nasolacrimal duct obstruction (HP:0000579)0.76166481
128Aortic aneurysm (HP:0004942)0.76112329
129Septate vagina (HP:0001153)0.74777982
130Dry skin (HP:0000958)0.74435343
131Coronal craniosynostosis (HP:0004440)0.73738658
132Breast hypoplasia (HP:0003187)0.71880017
133Bilateral sensorineural hearing impairment (HP:0008619)0.71168333
134Acanthocytosis (HP:0001927)0.70078113

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.53738359
2EPHA24.26160594
3MAPKAPK34.21464448
4FER4.00066405
5ERN13.73996715
6MAP3K63.32585069
7EPHB23.16380059
8TAOK13.05020957
9MAP3K32.90457436
10STK242.82035485
11TRIB32.64961500
12LATS12.50807836
13MAP3K22.44558344
14PIK3CG2.17998740
15TTN2.10052245
16MAP3K112.08090634
17RPS6KB22.02688964
18MAP3K122.01782395
19MAP2K61.78723028
20STK391.78445706
21EEF2K1.69283167
22LATS21.65453157
23ARAF1.62406116
24EPHB11.57332339
25FGFR11.53576119
26NME11.50904023
27INSRR1.48913569
28MAPK71.44705276
29LMTK21.43638782
30BCR1.40561025
31FGFR21.39110769
32MST1R1.34318750
33MAP3K11.28657395
34ADRBK11.26304715
35MAP2K31.24534415
36RIPK11.23870912
37STK31.19004338
38FGFR41.18891095
39KSR21.18232071
40PKN21.16933585
41CDK61.14355805
42BMX1.14339140
43MAPKAPK51.14092053
44PRKD21.13767893
45MAP3K91.09282204
46PBK1.07492217
47MAPKAPK21.07334562
48ABL21.05320453
49BLK1.03398602
50LRRK21.02975933
51PDGFRA1.00373854
52FGFR30.99105942
53PTK60.98902121
54MAP3K70.98538824
55NEK90.88170483
56MOS0.88027412
57MAP2K40.86344406
58SIK10.83151768
59MARK10.82687752
60ROCK10.80962798
61RPS6KA40.80346226
62MAP2K10.79467824
63PTK20.79006023
64OBSCN0.77841635
65PIK3CA0.77254095
66DYRK1B0.75454373
67STK38L0.75420850
68STK380.73805467
69PIM20.72059340
70TESK10.72036330
71SMG10.71672807
72PRKD10.70453177
73MET0.69697211
74DAPK30.68325670
75PAK40.67151373
76DDR20.66757930
77PAK30.65332039
78CDK190.65063590
79NTRK20.63411534
80PRPF4B0.62513812
81NEK10.59515456
82PRKCI0.56573836
83PDGFRB0.56113047
84ADRBK20.56005542
85TYRO30.55305601
86TRPM70.55142382
87PINK10.54848405
88OXSR10.54555759
89MAP3K130.54077202
90ERBB40.53888830
91MAP3K50.53215757
92TGFBR10.52882835
93MAP3K100.52360514
94PKN10.52335176
95PRKCH0.52010331
96RET0.50222751
97MINK10.50118834
98ERBB20.46299220
99CASK0.45443747
100MAPK120.45438832
101ERBB30.44902201
102ALK0.44297664
103TAF10.44225895
104PAK60.43647918
105LIMK10.43139827
106PRKG20.42745838
107RPS6KB10.42728976
108EPHA30.42674691
109RPS6KA10.42550632
110PAK20.41915882
111PHKG20.41619016
112PHKG10.41619016
113GSK3A0.40730493
114MST40.40174974
115PRKCE0.40086508
116CSNK1E0.39146113
117JAK10.39145235
118CDC42BPA0.38587373
119MAP2K20.38220270
120MARK20.36893070
121ILK0.36438332
122TYK20.33312502
123NME20.32727697
124MAPK40.31588706
125NTRK10.31297931
126JAK20.31118536
127KIT0.30384721
128SIK30.29054332
129CDK70.29002845
130RPS6KA20.27239696
131FYN0.26804304
132MAP3K80.25783510
133PDPK10.23474722
134CSNK1A10.23456637
135SRC0.23295407
136GRK60.23090707
137FLT30.22255119
138ROCK20.21924821
139STK110.21625712
140CLK10.21216796
141AKT30.21203922
142PRKACA0.21188624
143CSNK1D0.20967935
144HCK0.20383375
145TGFBR20.20212290

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.79647042
2Linoleic acid metabolism_Homo sapiens_hsa005914.76897132
3Vitamin digestion and absorption_Homo sapiens_hsa049773.73497638
4Fat digestion and absorption_Homo sapiens_hsa049753.09196720
5Fatty acid elongation_Homo sapiens_hsa000622.90090204
6Fatty acid biosynthesis_Homo sapiens_hsa000612.69827595
7Ether lipid metabolism_Homo sapiens_hsa005652.51374514
8Basal cell carcinoma_Homo sapiens_hsa052172.23997182
9Retinol metabolism_Homo sapiens_hsa008301.91500072
10Arachidonic acid metabolism_Homo sapiens_hsa005901.89256131
11Phenylalanine metabolism_Homo sapiens_hsa003601.86907075
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.78813414
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.74327265
14VEGF signaling pathway_Homo sapiens_hsa043701.74055914
15Melanogenesis_Homo sapiens_hsa049161.62780637
16Glycerolipid metabolism_Homo sapiens_hsa005611.53131696
17Axon guidance_Homo sapiens_hsa043601.52836553
18Hedgehog signaling pathway_Homo sapiens_hsa043401.42939517
19Histidine metabolism_Homo sapiens_hsa003401.38828040
20Glioma_Homo sapiens_hsa052141.38290600
21Bladder cancer_Homo sapiens_hsa052191.34502346
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.32561010
23GnRH signaling pathway_Homo sapiens_hsa049121.31412880
24Thyroid cancer_Homo sapiens_hsa052161.30362246
25Proteoglycans in cancer_Homo sapiens_hsa052051.29653831
26Hippo signaling pathway_Homo sapiens_hsa043901.26000395
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21140134
28Caffeine metabolism_Homo sapiens_hsa002321.16083020
29Tight junction_Homo sapiens_hsa045301.15851710
30Acute myeloid leukemia_Homo sapiens_hsa052211.12709510
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10738502
32Pancreatic secretion_Homo sapiens_hsa049721.08611237
33Long-term potentiation_Homo sapiens_hsa047201.07538679
34Dorso-ventral axis formation_Homo sapiens_hsa043201.05395215
35Steroid biosynthesis_Homo sapiens_hsa001001.01741333
36PPAR signaling pathway_Homo sapiens_hsa033201.01697451
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00787739
38Mineral absorption_Homo sapiens_hsa049780.99882040
39ECM-receptor interaction_Homo sapiens_hsa045120.98810409
40Adherens junction_Homo sapiens_hsa045200.97151517
41Tyrosine metabolism_Homo sapiens_hsa003500.96288860
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96041678
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95013794
44Collecting duct acid secretion_Homo sapiens_hsa049660.94878312
45Nitrogen metabolism_Homo sapiens_hsa009100.93305152
46Pertussis_Homo sapiens_hsa051330.90762230
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.89729805
48Non-small cell lung cancer_Homo sapiens_hsa052230.86516580
49Long-term depression_Homo sapiens_hsa047300.85095776
50Estrogen signaling pathway_Homo sapiens_hsa049150.85008793
51Endometrial cancer_Homo sapiens_hsa052130.85007531
52Staphylococcus aureus infection_Homo sapiens_hsa051500.82949397
53Ras signaling pathway_Homo sapiens_hsa040140.82630169
54Lysosome_Homo sapiens_hsa041420.81312600
55beta-Alanine metabolism_Homo sapiens_hsa004100.79688138
56Wnt signaling pathway_Homo sapiens_hsa043100.78463053
57Amoebiasis_Homo sapiens_hsa051460.77886489
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.77691918
59Phototransduction_Homo sapiens_hsa047440.77648082
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76154595
61Renin secretion_Homo sapiens_hsa049240.73783020
62Gastric acid secretion_Homo sapiens_hsa049710.73762784
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72236293
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72160532
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.69368334
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67275892
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67011168
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.66632474
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64959509
70Ovarian steroidogenesis_Homo sapiens_hsa049130.64088173
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63299398
72MicroRNAs in cancer_Homo sapiens_hsa052060.62913021
73Fatty acid metabolism_Homo sapiens_hsa012120.61096662
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60438618
75Insulin resistance_Homo sapiens_hsa049310.59381111
76Amphetamine addiction_Homo sapiens_hsa050310.57251030
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.56901320
78Rap1 signaling pathway_Homo sapiens_hsa040150.55293124
79Protein digestion and absorption_Homo sapiens_hsa049740.55103684
80Vibrio cholerae infection_Homo sapiens_hsa051100.54765515
81Gap junction_Homo sapiens_hsa045400.54394270
82Hepatitis C_Homo sapiens_hsa051600.54364087
83Oxytocin signaling pathway_Homo sapiens_hsa049210.54229210
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54065737
85Salivary secretion_Homo sapiens_hsa049700.53512660
86Salmonella infection_Homo sapiens_hsa051320.52446268
87Focal adhesion_Homo sapiens_hsa045100.52044139
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51845613
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.50663797
90Platelet activation_Homo sapiens_hsa046110.49723860
91Serotonergic synapse_Homo sapiens_hsa047260.49460134
92Peroxisome_Homo sapiens_hsa041460.49107968
93Renal cell carcinoma_Homo sapiens_hsa052110.48147616
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47888609
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47858600
96Fatty acid degradation_Homo sapiens_hsa000710.47780836
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47192395
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47123338
99Circadian entrainment_Homo sapiens_hsa047130.46359897
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45763568
101Pyruvate metabolism_Homo sapiens_hsa006200.45002774
102Chemical carcinogenesis_Homo sapiens_hsa052040.44751861
103Olfactory transduction_Homo sapiens_hsa047400.44526962
104Butanoate metabolism_Homo sapiens_hsa006500.44425878
105ErbB signaling pathway_Homo sapiens_hsa040120.44123079
106TGF-beta signaling pathway_Homo sapiens_hsa043500.43616149
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43191848
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41881502
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41657363
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40909767
111Tuberculosis_Homo sapiens_hsa051520.39515724
112p53 signaling pathway_Homo sapiens_hsa041150.39375315
113Renin-angiotensin system_Homo sapiens_hsa046140.38435893
114Insulin signaling pathway_Homo sapiens_hsa049100.38165887
115Toxoplasmosis_Homo sapiens_hsa051450.37967472
116Sphingolipid metabolism_Homo sapiens_hsa006000.37505730
117Chronic myeloid leukemia_Homo sapiens_hsa052200.36708790
118Prion diseases_Homo sapiens_hsa050200.36339795
119Malaria_Homo sapiens_hsa051440.36276097
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35499152
121Notch signaling pathway_Homo sapiens_hsa043300.35304326
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33685884
123Prolactin signaling pathway_Homo sapiens_hsa049170.32497559
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31522513
125Circadian rhythm_Homo sapiens_hsa047100.30652141
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30047103
127Dopaminergic synapse_Homo sapiens_hsa047280.29265170
128Calcium signaling pathway_Homo sapiens_hsa040200.29204086
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.28107460
130Glutathione metabolism_Homo sapiens_hsa004800.27886672
131Glucagon signaling pathway_Homo sapiens_hsa049220.27394862
132Synaptic vesicle cycle_Homo sapiens_hsa047210.24537966
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23675673
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18756337
135Sulfur metabolism_Homo sapiens_hsa009200.18294112
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15634545

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