KRT35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)8.10347301
2virion attachment to host cell (GO:0019062)8.10347301
3peptide cross-linking (GO:0018149)7.97003737
4citrulline biosynthetic process (GO:0019240)7.41019435
5hair follicle morphogenesis (GO:0031069)7.28710013
6adhesion of symbiont to host (GO:0044406)6.85511822
7establishment of skin barrier (GO:0061436)6.55164151
8epidermis development (GO:0008544)6.24302596
9cell wall macromolecule metabolic process (GO:0044036)6.15658184
10cell wall macromolecule catabolic process (GO:0016998)6.15658184
11intermediate filament cytoskeleton organization (GO:0045104)5.96860506
12keratinocyte differentiation (GO:0030216)5.94936791
13linoleic acid metabolic process (GO:0043651)5.83436305
14intermediate filament-based process (GO:0045103)5.79321669
15regulation of water loss via skin (GO:0033561)5.57932596
16hemidesmosome assembly (GO:0031581)5.53756685
17long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.41478209
18hair cycle process (GO:0022405)5.24752037
19molting cycle process (GO:0022404)5.24752037
20bundle of His cell to Purkinje myocyte communication (GO:0086069)5.16269618
21long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.99515466
22very long-chain fatty acid metabolic process (GO:0000038)4.99044111
23fatty-acyl-CoA biosynthetic process (GO:0046949)4.83778683
24citrulline metabolic process (GO:0000052)4.80728318
25epidermal cell differentiation (GO:0009913)4.65528520
26keratinocyte development (GO:0003334)4.40128099
27skin morphogenesis (GO:0043589)4.34955153
28tooth mineralization (GO:0034505)4.25719039
29negative regulation of keratinocyte proliferation (GO:0010839)4.25403747
30retinol metabolic process (GO:0042572)4.19145563
31bone trabecula formation (GO:0060346)4.06335030
32peptidyl-arginine modification (GO:0018195)4.04778614
33hair cycle (GO:0042633)30.4481426
34molting cycle (GO:0042303)30.4481426
35acyl-CoA biosynthetic process (GO:0071616)3.91490915
36thioester biosynthetic process (GO:0035384)3.91490915
37fatty-acyl-CoA metabolic process (GO:0035337)3.89984101
38keratinocyte proliferation (GO:0043616)3.84291488
39positive regulation of hair follicle development (GO:0051798)3.74454771
40positive regulation of hair cycle (GO:0042635)3.74454771
41multicellular organismal water homeostasis (GO:0050891)3.73441599
42hair follicle development (GO:0001942)3.71589733
43regulation of hair follicle development (GO:0051797)3.54348903
44long-chain fatty acid biosynthetic process (GO:0042759)3.42904608
45regulation of keratinocyte differentiation (GO:0045616)3.40384361
46epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.40066712
47positive regulation of keratinocyte differentiation (GO:0045618)3.33561608
48positive regulation of meiotic cell cycle (GO:0051446)3.28562543
49positive regulation of chemokine secretion (GO:0090197)3.22836748
50regulation of sequestering of triglyceride (GO:0010889)3.21513344
51regulation of hair cycle (GO:0042634)3.20934053
52defense response to fungus (GO:0050832)3.17988557
53atrioventricular valve morphogenesis (GO:0003181)3.17054220
54epithelium development (GO:0060429)3.17000706
55regulation of mesenchymal cell apoptotic process (GO:2001053)3.10726189
56primary alcohol metabolic process (GO:0034308)3.09215632
57alpha-linolenic acid metabolic process (GO:0036109)3.06035988
58wound healing, spreading of epidermal cells (GO:0035313)3.03826439
59water homeostasis (GO:0030104)3.02841046
60positive regulation of epidermis development (GO:0045684)2.96452657
61disruption of cells of other organism (GO:0044364)2.93176080
62killing of cells of other organism (GO:0031640)2.93176080
63gap junction assembly (GO:0016264)2.90395540
64negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.89917897
65ectoderm development (GO:0007398)2.89076315
66regulation of chemokine secretion (GO:0090196)2.88902287
67negative regulation of cell fate specification (GO:0009996)2.85906669
68triglyceride biosynthetic process (GO:0019432)2.83694279
69phosphatidylinositol acyl-chain remodeling (GO:0036149)2.81234979
70outflow tract septum morphogenesis (GO:0003148)2.79730227
71lipoxygenase pathway (GO:0019372)2.73418856
72cell surface receptor signaling pathway involved in heart development (GO:0061311)2.70894516
73neutral lipid biosynthetic process (GO:0046460)2.70857566
74acylglycerol biosynthetic process (GO:0046463)2.70857566
75skeletal muscle adaptation (GO:0043501)2.70304626
76regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.65185139
77cranial suture morphogenesis (GO:0060363)2.62285303
78lymph vessel development (GO:0001945)2.62195336
79regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.61500011
80fatty acid elongation (GO:0030497)2.59731823
81regulation of keratinocyte proliferation (GO:0010837)2.58686308
82regulation of epidermis development (GO:0045682)2.57885160
83regulation of epidermal cell differentiation (GO:0045604)2.56130603
84phosphatidylserine acyl-chain remodeling (GO:0036150)2.55318302
85daunorubicin metabolic process (GO:0044597)2.46883222
86polyketide metabolic process (GO:0030638)2.46883222
87doxorubicin metabolic process (GO:0044598)2.46883222
88planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45975850
89myotube differentiation (GO:0014902)2.45170323
90positive regulation of epidermal cell differentiation (GO:0045606)2.44386450
91phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.44314087
92negative regulation of protein localization to plasma membrane (GO:1903077)2.43616219
93lateral sprouting from an epithelium (GO:0060601)2.36578733
94striated muscle atrophy (GO:0014891)2.34523838
95embryonic camera-type eye development (GO:0031076)2.34466854
96regulation of skeletal muscle contraction (GO:0014819)2.32908520
97non-canonical Wnt signaling pathway (GO:0035567)2.32715778
98negative regulation of epidermis development (GO:0045683)2.31919231
99primary alcohol catabolic process (GO:0034310)2.30791771
100acyl-CoA metabolic process (GO:0006637)2.28945084
101thioester metabolic process (GO:0035383)2.28945084
102establishment of planar polarity (GO:0001736)2.28701247
103establishment of tissue polarity (GO:0007164)2.28701247
104positive regulation of monocyte chemotaxis (GO:0090026)2.28427778
105skin development (GO:0043588)2.27702667
106regulation of somitogenesis (GO:0014807)2.27062738
107response to phenylpropanoid (GO:0080184)2.26228399
108phosphatidylcholine acyl-chain remodeling (GO:0036151)2.25492508
109regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.24790145
110regulation of cardioblast differentiation (GO:0051890)2.24545026
111muscle atrophy (GO:0014889)2.21232471
112regulation of heart rate by cardiac conduction (GO:0086091)2.20385859
113negative regulation of execution phase of apoptosis (GO:1900118)2.18165051
114one-carbon compound transport (GO:0019755)2.17592875
115response to fungus (GO:0009620)2.16502967
116ventricular cardiac muscle cell action potential (GO:0086005)2.16105407
117outer ear morphogenesis (GO:0042473)2.16006669
118ephrin receptor signaling pathway (GO:0048013)2.15075067
119carnitine metabolic process (GO:0009437)2.14786939
120craniofacial suture morphogenesis (GO:0097094)2.14345646
121phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.12645306
122regulation of defense response to virus by host (GO:0050691)2.10554181
123axon extension involved in axon guidance (GO:0048846)2.10431434
124neuron projection extension involved in neuron projection guidance (GO:1902284)2.10431434
125wound healing, spreading of cells (GO:0044319)2.10236948
126negative regulation of stem cell proliferation (GO:2000647)2.09444755
127eyelid development in camera-type eye (GO:0061029)2.05168054
128negative regulation of skeletal muscle tissue development (GO:0048642)2.05081796
129regulation of cardioblast proliferation (GO:0003264)2.04893505
130regulation of secondary heart field cardioblast proliferation (GO:0003266)2.04893505
131aging (GO:0007568)2.04856650
132positive regulation of meiosis (GO:0045836)2.01963279
133phosphatidylserine metabolic process (GO:0006658)2.00367323
134keratinization (GO:0031424)11.4584782
135intermediate filament organization (GO:0045109)10.9238886
136desmosome organization (GO:0002934)10.7570729
137negative regulation of mesenchymal cell apoptotic process (GO:2001054)1.99851828
138fatty acid biosynthetic process (GO:0006633)1.97595812
139negative regulation of axon extension involved in axon guidance (GO:0048843)1.94405564
140regulation of phospholipase A2 activity (GO:0032429)1.93102639
141fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)1.85181615
142ethanol metabolic process (GO:0006067)1.80359619
143unsaturated fatty acid biosynthetic process (GO:0006636)1.78824158
144regulation of protein polyubiquitination (GO:1902914)1.69714623
145alditol phosphate metabolic process (GO:0052646)1.69268782
146phosphatidic acid metabolic process (GO:0046473)1.68827807
147phosphatidic acid biosynthetic process (GO:0006654)1.68827807
148detection of bacterium (GO:0016045)1.63429978
149positive regulation of macrophage derived foam cell differentiation (GO:0010744)1.56996387
150epithelial cell differentiation involved in prostate gland development (GO:0060742)1.56940400
151negative regulation of glial cell proliferation (GO:0060253)1.56064169
152positive regulation of lipid storage (GO:0010884)1.55877379
153amino-acid betaine metabolic process (GO:0006577)1.52646806
154fat-soluble vitamin biosynthetic process (GO:0042362)1.51100943
155regulation of natural killer cell differentiation (GO:0032823)1.49608777
156lipid storage (GO:0019915)1.48276693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.36761152
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.14244110
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.11198413
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25944698
5TP63_17297297_ChIP-ChIP_HaCaT_Human11.8086087
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.87291598
7JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84238434
8CTCF_20526341_ChIP-Seq_ESCs_Human1.77577977
9SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75693205
10EZH2_27304074_Chip-Seq_ESCs_Mouse1.71020247
11NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.70872634
12SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67951692
13BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.67219454
14BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66075007
15RNF2_27304074_Chip-Seq_ESCs_Mouse1.59420573
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59319049
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56398901
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54555271
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54555271
20* TP53_20018659_ChIP-ChIP_R1E_Mouse1.53423700
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51285891
22EGR1_19032775_ChIP-ChIP_M12_Human1.50317477
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49211486
24AHR_22903824_ChIP-Seq_MCF-7_Human1.48010154
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.47995064
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.47028468
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.46730799
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46484057
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.43460828
30CTCF_27219007_Chip-Seq_Bcells_Human1.43277388
31TAF2_19829295_ChIP-Seq_ESCs_Human1.43208331
32RXR_22108803_ChIP-Seq_LS180_Human1.43055305
33MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.39030843
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37623122
35AR_21572438_ChIP-Seq_LNCaP_Human1.36297335
36NANOG_20526341_ChIP-Seq_ESCs_Human1.35308371
37TP53_18474530_ChIP-ChIP_U2OS_Human1.33867023
38E2F1_20622854_ChIP-Seq_HELA_Human1.33279992
39CSB_26484114_Chip-Seq_FIBROBLAST_Human1.31936222
40P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.30738240
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28369317
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.28286217
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27362586
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27342207
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26139421
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26139421
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24757817
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23968034
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22711804
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.21423233
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.20377050
52TP63_22573176_ChIP-Seq_HFKS_Human1.19746556
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.16561160
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15356453
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15175913
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15132781
57* P68_20966046_ChIP-Seq_HELA_Human1.14692591
58ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13882791
59TP63_23658742_ChIP-Seq_EP156T_Human1.13311485
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11162744
61P53_21459846_ChIP-Seq_SAOS-2_Human1.08769243
62* ERG_20517297_ChIP-Seq_VCAP_Human1.07357293
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07262564
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06455567
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05226060
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04673547
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04512182
68RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03970089
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03762148
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02624398
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02001941
72ERG_21242973_ChIP-ChIP_JURKAT_Human0.99685707
73CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96614936
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96283760
75FOXO3_23340844_ChIP-Seq_DLD1_Human0.96130325
76RACK7_27058665_Chip-Seq_MCF-7_Human0.94499402
77HTT_18923047_ChIP-ChIP_STHdh_Human0.92937790
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92894034
79LXR_22292898_ChIP-Seq_THP-1_Human0.91665696
80TRIM28_21343339_ChIP-Seq_HEK293_Human0.91508028
81KLF5_25053715_ChIP-Seq_YYC3_Human0.91314534
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90727756
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90714539
84TCF4_18268006_ChIP-ChIP_LS174T_Human0.90600348
85GATA6_21074721_ChIP-Seq_CACO-2_Human0.90164579
86MYC_19829295_ChIP-Seq_ESCs_Human0.89339632
87* CEBPB_22108803_ChIP-Seq_LS180_Human0.89165689
88P300_27268052_Chip-Seq_Bcells_Human0.88130702
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86974302
90* GATA4_25053715_ChIP-Seq_YYC3_Human0.86361522
91CJUN_26792858_Chip-Seq_BT549_Human0.86051275
92ESR2_21235772_ChIP-Seq_MCF-7_Human0.85797337
93* BCL6_27268052_Chip-Seq_Bcells_Human0.85710050
94UBF1/2_26484160_Chip-Seq_HMECs_Human0.85135162
95CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.82727704
96E2F1_17053090_ChIP-ChIP_MCF-7_Human0.82388230
97* PHF8_20622854_ChIP-Seq_HELA_Human0.82076122
98* YY1_22570637_ChIP-Seq_MALME-3M_Human0.81516297
99RING1B_27294783_Chip-Seq_NPCs_Mouse0.80632605
100SA1_27219007_Chip-Seq_ERYTHROID_Human0.79332327
101SMC4_20622854_ChIP-Seq_HELA_Human0.78987942
102RAC3_21632823_ChIP-Seq_H3396_Human0.78854888
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77459321
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.77459321
105FOXH1_21741376_ChIP-Seq_EPCs_Human0.77353037
106OCT4_20526341_ChIP-Seq_ESCs_Human0.77111094
107KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76818571
108* BCOR_27268052_Chip-Seq_Bcells_Human0.75067259
109RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74080844
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74053406
111GATA3_24758297_ChIP-Seq_MCF-7_Human0.73733879
112NCOR_22424771_ChIP-Seq_293T_Human0.73370594
113GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73163830
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.72174399
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.71502432
116BCAT_22108803_ChIP-Seq_LS180_Human0.71468316
117RNF2_27304074_Chip-Seq_NSC_Mouse0.71031754
118SOX2_19829295_ChIP-Seq_ESCs_Human0.70982617
119NANOG_19829295_ChIP-Seq_ESCs_Human0.70982617
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70814295
121SOX2_20726797_ChIP-Seq_SW620_Human0.70604640
122FOXA1_25329375_ChIP-Seq_VCAP_Human0.70432738
123FOXA1_27270436_Chip-Seq_PROSTATE_Human0.70432738
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70415322
125FOXH1_21741376_ChIP-Seq_ESCs_Human0.70120145
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69721790
127PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.69233062
128PHF8_20622853_ChIP-Seq_HELA_Human0.69134110
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.69107799
130CBP_20019798_ChIP-Seq_JUKART_Human0.69107799
131HNFA_21074721_ChIP-Seq_CACO-2_Human0.68815872
132AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68544934
133GATA3_21867929_ChIP-Seq_TH1_Mouse0.66781728
134AR_20517297_ChIP-Seq_VCAP_Human0.64768070
135GATA3_21878914_ChIP-Seq_MCF-7_Human0.64669248
136KAP1_27257070_Chip-Seq_ESCs_Mouse0.64665337
137SRY_22984422_ChIP-ChIP_TESTIS_Rat0.63716476
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.63124748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.77214477
2MP0002098_abnormal_vibrissa_morphology6.71474855
3MP0000647_abnormal_sebaceous_gland5.97154123
4MP0002796_impaired_skin_barrier5.72402507
5MP0005275_abnormal_skin_tensile5.13552204
6MP0000383_abnormal_hair_follicle4.78346069
7MP0010234_abnormal_vibrissa_follicle4.22319824
8MP0010678_abnormal_skin_adnexa3.97752545
9MP0000377_abnormal_hair_follicle3.89139821
10MP0009379_abnormal_foot_pigmentation3.62951446
11MP0000427_abnormal_hair_cycle3.62373381
12MP0005501_abnormal_skin_physiology3.59158505
13MP0002254_reproductive_system_inflammat3.20474963
14MP0003705_abnormal_hypodermis_morpholog3.02058186
15MP0004381_abnormal_hair_follicle2.88737914
16MP0001216_abnormal_epidermal_layer2.74833554
17MP0002060_abnormal_skin_morphology2.45407131
18MP0010771_integument_phenotype2.42963735
19MP0001243_abnormal_dermal_layer2.41259994
20MP0000367_abnormal_coat/_hair2.22034249
21MP0003453_abnormal_keratinocyte_physiol2.04751747
22MP0004947_skin_inflammation2.04484382
23MP0002234_abnormal_pharynx_morphology2.02821613
24MP0000467_abnormal_esophagus_morphology1.90366319
25MP0005409_darkened_coat_color1.87959772
26MP0000762_abnormal_tongue_morphology1.85318526
27MP0003941_abnormal_skin_development1.75213214
28MP0000566_synostosis1.73711458
29MP0003011_delayed_dark_adaptation1.63395543
30MP0009931_abnormal_skin_appearance1.47882138
31MP0009053_abnormal_anal_canal1.44317774
32MP0001346_abnormal_lacrimal_gland1.31444306
33MP0003566_abnormal_cell_adhesion1.20210067
34MP0001191_abnormal_skin_condition1.14387727
35MP0005647_abnormal_sex_gland1.11364166
36MP0002095_abnormal_skin_pigmentation1.07676155
37MP0003300_gastrointestinal_ulcer1.04814083
38MP0000678_abnormal_parathyroid_gland1.02581476
39MP0001485_abnormal_pinna_reflex0.87499636
40MP0002249_abnormal_larynx_morphology0.86106902
41MP0010030_abnormal_orbit_morphology0.83173806
42MP0008438_abnormal_cutaneous_collagen0.79929642
43MP0006035_abnormal_mitochondrial_morpho0.78674608
44MP0003755_abnormal_palate_morphology0.75478560
45MP0004885_abnormal_endolymph0.74067745
46MP0001340_abnormal_eyelid_morphology0.73599537
47MP0001851_eye_inflammation0.72859608
48MP0005174_abnormal_tail_pigmentation0.70022925
49MP0004185_abnormal_adipocyte_glucose0.67537705
50MP0005075_abnormal_melanosome_morpholog0.66241982
51MP0000627_abnormal_mammary_gland0.65455679
52MP0005248_abnormal_Harderian_gland0.64812972
53MP0000015_abnormal_ear_pigmentation0.63904451
54MP0002282_abnormal_trachea_morphology0.62870467
55MP0004742_abnormal_vestibular_system0.61663791
56MP0001188_hyperpigmentation0.60489289
57MP0002009_preneoplasia0.57633366
58MP0003878_abnormal_ear_physiology0.56743138
59MP0005377_hearing/vestibular/ear_phenot0.56743138
60MP0003385_abnormal_body_wall0.54935059
61MP0004264_abnormal_extraembryonic_tissu0.52218243
62MP0002177_abnormal_outer_ear0.51524104
63MP0002163_abnormal_gland_morphology0.51456851
64MP0000516_abnormal_urinary_system0.50721613
65MP0005367_renal/urinary_system_phenotyp0.50721613
66MP0000751_myopathy0.49949236
67MP0005451_abnormal_body_composition0.49740282
68MP0001849_ear_inflammation0.49695925
69MP0002111_abnormal_tail_morphology0.46243721
70MP0003315_abnormal_perineum_morphology0.45390557
71MP0005503_abnormal_tendon_morphology0.44876686
72MP0001784_abnormal_fluid_regulation0.40620358
73MP0003638_abnormal_response/metabolism_0.36869135
74MP0001661_extended_life_span0.36494128
75MP0005645_abnormal_hypothalamus_physiol0.35846823
76MP0005257_abnormal_intraocular_pressure0.34811644
77MP0005508_abnormal_skeleton_morphology0.32765204
78MP0005535_abnormal_body_temperature0.32311646
79MP0000681_abnormal_thyroid_gland0.31918306
80MP0002233_abnormal_nose_morphology0.31322706
81MP0003935_abnormal_craniofacial_develop0.30708809
82MP0000733_abnormal_muscle_development0.30044245
83MP0004782_abnormal_surfactant_physiolog0.29991518
84MP0000432_abnormal_head_morphology0.29650042
85MP0002697_abnormal_eye_size0.29337716
86MP0002109_abnormal_limb_morphology0.28737309
87MP0005379_endocrine/exocrine_gland_phen0.26629783
88MP0002877_abnormal_melanocyte_morpholog0.26027662
89MP0003763_abnormal_thymus_physiology0.25630801
90MP0000049_abnormal_middle_ear0.25058976
91MP0009384_cardiac_valve_regurgitation0.24444946
92MP0000613_abnormal_salivary_gland0.22678272
93MP0005646_abnormal_pituitary_gland0.20830484
94MP0009250_abnormal_appendicular_skeleto0.20750216
95MP0001879_abnormal_lymphatic_vessel0.20744572
96MP0008004_abnormal_stomach_pH0.20514636
97MP0002970_abnormal_white_adipose0.20348082
98MP0006138_congestive_heart_failure0.20330687
99MP0005671_abnormal_response_to0.19887776
100MP0004272_abnormal_basement_membrane0.19842755
101MP0003646_muscle_fatigue0.19203366
102MP0001905_abnormal_dopamine_level0.18978901
103MP0001881_abnormal_mammary_gland0.18919411
104MP0002116_abnormal_craniofacial_bone0.18749751
105MP0000749_muscle_degeneration0.18473091
106MP0004019_abnormal_vitamin_homeostasis0.18280583
107MP0001919_abnormal_reproductive_system0.17056260
108MP0002932_abnormal_joint_morphology0.16831879
109MP0002115_abnormal_skeleton_extremities0.16309334
110MP0003937_abnormal_limbs/digits/tail_de0.16020478
111MP0003950_abnormal_plasma_membrane0.15945461
112MP0005023_abnormal_wound_healing0.15750424
113MP0000538_abnormal_urinary_bladder0.15567363
114MP0002896_abnormal_bone_mineralization0.14780639
115MP0001984_abnormal_olfaction0.14624225
116MP0005452_abnormal_adipose_tissue0.14539202
117MP0001286_abnormal_eye_development0.14380706
118MP0000465_gastrointestinal_hemorrhage0.13613138
119MP0000470_abnormal_stomach_morphology0.13486403
120MP0005171_absent_coat_pigmentation0.13296921
121MP0003045_fibrosis0.13098308
122MP0004858_abnormal_nervous_system0.11176307
123MP0003936_abnormal_reproductive_system0.11169199
124MP0000026_abnormal_inner_ear0.11036168
125MP0000685_abnormal_immune_system0.10780587
126MP0002166_altered_tumor_susceptibility0.10533573
127MP0002933_joint_inflammation0.09582867
128MP0010386_abnormal_urinary_bladder0.08339477
129MP0002006_tumorigenesis0.06599068
130MP0002653_abnormal_ependyma_morphology0.06301618
131MP0009333_abnormal_splenocyte_physiolog0.04763826
132MP0003191_abnormal_cellular_cholesterol0.03994797
133MP0005551_abnormal_eye_electrophysiolog0.03809473
134MP0003123_paternal_imprinting0.03487043
135MP0010368_abnormal_lymphatic_system0.03445775
136MP0002090_abnormal_vision0.03282497
137MP0000462_abnormal_digestive_system0.01668083
138MP0005332_abnormal_amino_acid0.01501680
139MP0002971_abnormal_brown_adipose0.00789335

Predicted human phenotypes

RankGene SetZ-score
1Woolly hair (HP:0002224)9.91950127
2Abnormality of hair growth rate (HP:0011363)9.33108342
3Slow-growing hair (HP:0002217)9.33108342
4Pili torti (HP:0003777)8.72026374
5Brittle hair (HP:0002299)8.06436597
6Nail dystrophy (HP:0008404)6.72236705
7Absent eyebrow (HP:0002223)6.17821153
8Alopecia of scalp (HP:0002293)6.08712919
9Abnormality of nail color (HP:0100643)5.97426830
10Follicular hyperkeratosis (HP:0007502)5.77302498
11Fragile nails (HP:0001808)5.74324352
12Abnormal hair laboratory examination (HP:0003328)5.33271047
13Palmoplantar hyperkeratosis (HP:0000972)5.03904539
14Onycholysis (HP:0001806)4.81004600
15Plantar hyperkeratosis (HP:0007556)4.79653653
16Palmar hyperkeratosis (HP:0010765)4.76818138
17Thick nail (HP:0001805)4.43297851
18Increased IgE level (HP:0003212)4.34306263
19Fine hair (HP:0002213)4.33671935
20Milia (HP:0001056)4.31807758
21Parakeratosis (HP:0001036)4.06108636
22Right ventricular cardiomyopathy (HP:0011663)3.95100161
23Abnormality of the axillary hair (HP:0100134)3.93150631
24Abnormality of secondary sexual hair (HP:0009888)3.93150631
25Erythema (HP:0010783)3.70997145
26Sparse eyelashes (HP:0000653)3.66435138
27Abnormality of the frontal sinuses (HP:0002687)3.51463522
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.45991707
29Amelogenesis imperfecta (HP:0000705)3.43503523
30Aplasia cutis congenita (HP:0001057)3.29549887
31Erythroderma (HP:0001019)3.23124513
32Abnormality of the parietal bone (HP:0002696)3.00138404
33Oral leukoplakia (HP:0002745)2.95448190
34Absent eyelashes (HP:0000561)2.88198885
35Curly hair (HP:0002212)2.86933135
36Abnormality of dental color (HP:0011073)2.81172014
37Unilateral renal agenesis (HP:0000122)2.66348244
38Ridged nail (HP:0001807)2.64396430
39Type 1 muscle fiber predominance (HP:0003803)2.59013178
40Congenital, generalized hypertrichosis (HP:0004540)2.50560729
41Neck muscle weakness (HP:0000467)2.49750888
42Dry hair (HP:0011359)2.46102454
43Natal tooth (HP:0000695)2.41642826
44Abnormal blistering of the skin (HP:0008066)2.41530275
45Corneal erosion (HP:0200020)2.34434588
46Hypohidrosis (HP:0000966)2.32429279
47Advanced eruption of teeth (HP:0006288)2.31706871
48Round ear (HP:0100830)2.19280766
49Blepharitis (HP:0000498)2.17974232
50Recurrent corneal erosions (HP:0000495)2.16654811
51Abnormality of molar morphology (HP:0011070)2.14695340
52Abnormality of molar (HP:0011077)2.14695340
53Congenital ichthyosiform erythroderma (HP:0007431)2.12287893
54Abnormality of the dental root (HP:0006486)2.11236065
55Taurodontia (HP:0000679)2.11236065
56Abnormality of permanent molar morphology (HP:0011071)2.11236065
57Abnormality of the neuromuscular junction (HP:0003398)2.09110745
58Fatigable weakness (HP:0003473)2.09110745
59Atrophic scars (HP:0001075)2.08604493
60Ventricular tachycardia (HP:0004756)2.04715890
61Palmoplantar keratoderma (HP:0000982)2.03714679
62Hypotrichosis (HP:0001006)12.9649940
63Distal arthrogryposis (HP:0005684)1.98818804
64Ectropion (HP:0000656)1.97963664
65Nemaline bodies (HP:0003798)1.97666784
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93323998
67Pruritus (HP:0000989)1.92454105
68Muscle fiber inclusion bodies (HP:0100299)1.88505887
69Lip pit (HP:0100267)1.83616136
70Torticollis (HP:0000473)1.83261612
71Coarse hair (HP:0002208)1.82808500
72Furrowed tongue (HP:0000221)1.81843007
73Abnormality of the dental pulp (HP:0006479)1.81436224
74Increased connective tissue (HP:0009025)1.80049960
75Distal lower limb muscle weakness (HP:0009053)1.78308197
76Widely patent fontanelles and sutures (HP:0004492)1.78252474
77Concave nail (HP:0001598)1.72274965
78Abnormality of the aortic arch (HP:0012303)1.70770758
79Carious teeth (HP:0000670)1.70315037
80Hamartoma of the eye (HP:0010568)1.69595455
81Down-sloping shoulders (HP:0200021)1.61818979
82Abnormality of the pupil (HP:0000615)1.61098150
83Intention tremor (HP:0002080)1.58412042
84Calcaneovalgus deformity (HP:0001848)1.57950331
85Corneal dystrophy (HP:0001131)1.56459093
86Hypergammaglobulinemia (HP:0010702)1.53723786
87Difficulty walking (HP:0002355)1.53566209
88Hyporeflexia of lower limbs (HP:0002600)1.53266742
89Ulnar deviation of the wrist (HP:0003049)1.53205671
90Exercise-induced myalgia (HP:0003738)1.52997443
91Keratoconjunctivitis sicca (HP:0001097)1.52272398
92Fragile skin (HP:0001030)1.52012082
93Craniofacial hyperostosis (HP:0004493)1.49890589
94Absent hair (HP:0002298)1.49498961
95Abnormality of the fingernails (HP:0001231)1.48086623
96Urticaria (HP:0001025)1.46750498
97Craniofacial dystonia (HP:0012179)1.44806898
98Sparse scalp hair (HP:0002209)1.42815259
99Gangrene (HP:0100758)1.41880056
100Heterogeneous (HP:0001425)1.40793087
101Conjunctival hamartoma (HP:0100780)1.40696889
102Deformed tarsal bones (HP:0008119)1.38948957
103Anonychia (HP:0001798)1.38010986
104Distal lower limb amyotrophy (HP:0008944)1.37541235
105Keratoconjunctivitis (HP:0001096)1.36324403
106Myopathic facies (HP:0002058)1.36159631
107Tetany (HP:0001281)1.34225632
108Abnormality of placental membranes (HP:0011409)1.31918194
109Amniotic constriction ring (HP:0009775)1.31918194
110Multifactorial inheritance (HP:0001426)1.24730751
111Acanthosis nigricans (HP:0000956)1.15746120
112Hyperhidrosis (HP:0000975)1.06511208
113Laryngomalacia (HP:0001601)1.03134243
114Abnormality of the salivary glands (HP:0010286)0.98129966
115Neonatal onset (HP:0003623)0.93889467
116Skin ulcer (HP:0200042)0.89110069
117Seborrheic dermatitis (HP:0001051)0.86765417
118Acanthocytosis (HP:0001927)0.85472031
119Conical tooth (HP:0000698)0.84599951
120Aplasia involving bones of the extremities (HP:0009825)0.83941870
121Aplasia involving bones of the upper limbs (HP:0009823)0.83941870
122Aplasia of the phalanges of the hand (HP:0009802)0.83941870
123Dehydration (HP:0001944)0.83782238
124Hamartoma (HP:0010566)0.83731034
125Nasolacrimal duct obstruction (HP:0000579)0.83307170
126Melanocytic nevus (HP:0000995)0.83138030
127Cranial hyperostosis (HP:0004437)0.80784243
128Eczematoid dermatitis (HP:0000976)0.79367773
129Hypoplastic toenails (HP:0001800)0.79065232
130Split foot (HP:0001839)0.77852020
131Dry skin (HP:0000958)0.77069865
132Cerebellar dysplasia (HP:0007033)0.75756397
133Neonatal short-limb short stature (HP:0008921)0.72331242
134Generalized hyperpigmentation (HP:0007440)0.71509315
135Septate vagina (HP:0001153)0.71041348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.19640603
2TGFBR14.02507757
3SIK33.63878603
4FER3.57012099
5EPHB23.33919501
6KDR3.23682060
7CASK3.14312458
8LATS13.04978421
9STK392.95691738
10PIK3CG2.88384004
11MAP3K32.81131689
12MAPKAPK32.74983015
13MAP3K62.54071865
14EEF2K2.47594996
15TAOK32.32455719
16SMG12.26348758
17TIE12.25296265
18TESK22.15438204
19SIK12.13582613
20NME12.11976826
21STK38L2.07290027
22MYLK2.04926849
23INSRR1.96298771
24ERN11.92167512
25TESK11.87655165
26TAOK11.84881101
27MAP3K111.83211839
28MAPKAPK51.74327604
29OBSCN1.72022214
30OXSR11.69303759
31LMTK21.59692619
32TTN1.49575375
33EPHA41.44648891
34MAP3K71.43233889
35WNK41.41111301
36MARK31.30113326
37BCR1.29549588
38PRPF4B1.26915031
39SIK21.25212413
40MAP2K61.24396362
41MAP3K21.22925788
42TRPM71.21156820
43TNIK1.17178685
44STK241.16747987
45MAP3K121.16391101
46LATS21.15679610
47ZAK1.12974709
48FGFR11.10051718
49TNK21.07835317
50LIMK11.07444216
51BMX1.06740312
52EIF2AK31.04602309
53ERBB31.01132270
54PRKCI0.99687152
55MST1R0.98478784
56EPHB10.96719003
57ZAP700.94254135
58LRRK20.93709897
59MAPKAPK20.93553380
60RPS6KB20.93067641
61MAP3K10.91592505
62EPHA30.90887697
63ADRBK10.89095754
64PIM20.88459646
65FGFR20.87591059
66NTRK30.84758787
67TAF10.84543388
68IRAK10.79566622
69PHKG20.76934035
70PHKG10.76934035
71MAP3K140.75604763
72SCYL20.74301141
73MAP2K40.73767900
74GRK60.73362694
75DAPK20.70456998
76TAOK20.69647611
77MAPK70.69167225
78RIPK10.68527123
79AKT20.64712367
80RPS6KA40.63694972
81FGFR30.62977857
82NLK0.62561322
83ITK0.61695138
84MAPK150.59537308
85CCNB10.59167355
86TXK0.58941432
87MAPK110.57857589
88SGK20.56677012
89MKNK20.56577579
90SGK10.55277698
91PBK0.53495603
92CAMK40.53482618
93ADRBK20.53442492
94MARK20.52622962
95PAK20.52498048
96PIK3CA0.51507904
97MAP3K50.50683563
98AKT30.48719439
99SGK30.47040448
100CSK0.46911493
101PAK40.46659531
102ILK0.46543939
103CDK60.46408667
104MAPK120.46037294
105MUSK0.45736022
106DYRK1B0.45155305
107FGFR40.44984124
108JAK10.44427300
109PDK20.44287268
110PLK40.43442330
111RPS6KB10.42779585
112MAPK130.42382562
113STK380.41393612
114DDR20.40284732
115IKBKB0.40280555
116MINK10.40254628
117KIT0.40145088
118ROCK10.40107683
119ERBB40.40083727
120RPS6KA10.38194892
121STK30.37743514
122PRKCE0.37582179
123IKBKE0.37201537
124PDGFRA0.37161920
125CDK30.37004416
126NTRK20.36991064
127RIPK40.36445247
128MAP2K10.36434143
129CSNK1A10.35254432
130CDC42BPA0.35046240
131PTK60.34897600
132CLK10.34779039
133PRKACA0.34563437
134HCK0.34444914
135IRAK20.33637800
136ABL10.33370316
137MAPK80.32537239
138MAP4K20.32423049
139ABL20.30969900
140PTK20.29872820
141BLK0.29298573
142MAP2K30.28709060
143CDK70.27822943
144TRIB30.27443042
145IGF1R0.27265508
146MAP2K70.27129827
147SRC0.26974192
148PRKD20.26556904
149PRKD10.26511428
150DMPK0.25148992
151MAPK40.24600479
152PRKAA20.24180175
153GSK3A0.23693805
154IRAK40.23022320
155MET0.22183244
156ERBB20.21854550
157MAPK30.20670274
158INSR0.20442193

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049773.94494012
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.81695029
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.61706977
4Linoleic acid metabolism_Homo sapiens_hsa005913.55005967
5Basal cell carcinoma_Homo sapiens_hsa052173.52218337
6Fatty acid biosynthesis_Homo sapiens_hsa000613.26405106
7Hedgehog signaling pathway_Homo sapiens_hsa043402.42476765
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.40747175
9Fatty acid metabolism_Homo sapiens_hsa012122.33900244
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12728782
11Fatty acid elongation_Homo sapiens_hsa000622.05837291
12beta-Alanine metabolism_Homo sapiens_hsa004102.04715226
13Axon guidance_Homo sapiens_hsa043601.98311263
14Retinol metabolism_Homo sapiens_hsa008301.97770384
15Steroid biosynthesis_Homo sapiens_hsa001001.96258166
16Ether lipid metabolism_Homo sapiens_hsa005651.86360433
17Melanogenesis_Homo sapiens_hsa049161.71686437
18Arachidonic acid metabolism_Homo sapiens_hsa005901.67713581
19Nitrogen metabolism_Homo sapiens_hsa009101.61538166
20Hippo signaling pathway_Homo sapiens_hsa043901.53538716
21PPAR signaling pathway_Homo sapiens_hsa033201.51262419
22Glycerolipid metabolism_Homo sapiens_hsa005611.45103286
23Phenylalanine metabolism_Homo sapiens_hsa003601.43276848
24Wnt signaling pathway_Homo sapiens_hsa043101.41173362
25ECM-receptor interaction_Homo sapiens_hsa045121.35324835
26Fat digestion and absorption_Homo sapiens_hsa049751.34358292
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32856095
28Acute myeloid leukemia_Homo sapiens_hsa052211.30671609
29Mineral absorption_Homo sapiens_hsa049781.27541399
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.24966196
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.21569911
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20854718
33Long-term depression_Homo sapiens_hsa047301.19611474
34Adherens junction_Homo sapiens_hsa045201.19271997
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19147971
36Fatty acid degradation_Homo sapiens_hsa000711.18796177
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17975561
38Proteoglycans in cancer_Homo sapiens_hsa052051.17722191
39Butanoate metabolism_Homo sapiens_hsa006501.17468849
40Glioma_Homo sapiens_hsa052141.16822479
41Phototransduction_Homo sapiens_hsa047441.15818690
42Olfactory transduction_Homo sapiens_hsa047401.14266342
43Collecting duct acid secretion_Homo sapiens_hsa049661.12937330
44GnRH signaling pathway_Homo sapiens_hsa049121.12307376
45Notch signaling pathway_Homo sapiens_hsa043301.10010781
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08936517
47Ras signaling pathway_Homo sapiens_hsa040141.03812478
48Sphingolipid metabolism_Homo sapiens_hsa006001.03382094
49Pertussis_Homo sapiens_hsa051331.01305807
50Calcium signaling pathway_Homo sapiens_hsa040201.00461085
51Circadian entrainment_Homo sapiens_hsa047130.99122940
52Synaptic vesicle cycle_Homo sapiens_hsa047210.98895797
53Tight junction_Homo sapiens_hsa045300.97922844
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97623706
55Bladder cancer_Homo sapiens_hsa052190.96819444
56Long-term potentiation_Homo sapiens_hsa047200.95331920
57Nicotine addiction_Homo sapiens_hsa050330.95301878
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94885749
59Melanoma_Homo sapiens_hsa052180.90941214
60Sulfur metabolism_Homo sapiens_hsa009200.89237645
61Primary immunodeficiency_Homo sapiens_hsa053400.87506025
62Protein digestion and absorption_Homo sapiens_hsa049740.86048615
63Amoebiasis_Homo sapiens_hsa051460.85866929
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85852212
65Oxytocin signaling pathway_Homo sapiens_hsa049210.85833873
66Thyroid cancer_Homo sapiens_hsa052160.84720771
67MicroRNAs in cancer_Homo sapiens_hsa052060.84167472
68VEGF signaling pathway_Homo sapiens_hsa043700.83269618
69Endometrial cancer_Homo sapiens_hsa052130.81492751
70Tuberculosis_Homo sapiens_hsa051520.80765087
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79967409
72ErbB signaling pathway_Homo sapiens_hsa040120.79959718
73Rheumatoid arthritis_Homo sapiens_hsa053230.79202106
74Dilated cardiomyopathy_Homo sapiens_hsa054140.79183182
75Renin secretion_Homo sapiens_hsa049240.77741749
76Rap1 signaling pathway_Homo sapiens_hsa040150.72604009
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71828058
78Pathways in cancer_Homo sapiens_hsa052000.70572145
79Serotonergic synapse_Homo sapiens_hsa047260.70143939
80Propanoate metabolism_Homo sapiens_hsa006400.69875065
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68871116
82TNF signaling pathway_Homo sapiens_hsa046680.68804738
83Histidine metabolism_Homo sapiens_hsa003400.68571574
84Salivary secretion_Homo sapiens_hsa049700.68347111
85MAPK signaling pathway_Homo sapiens_hsa040100.67316705
86Pyruvate metabolism_Homo sapiens_hsa006200.66777551
87HTLV-I infection_Homo sapiens_hsa051660.65778401
88Gastric acid secretion_Homo sapiens_hsa049710.65172495
89Hepatitis C_Homo sapiens_hsa051600.65156704
90Peroxisome_Homo sapiens_hsa041460.64673331
91Pancreatic secretion_Homo sapiens_hsa049720.64282468
92Focal adhesion_Homo sapiens_hsa045100.64180617
93TGF-beta signaling pathway_Homo sapiens_hsa043500.61905206
94Toxoplasmosis_Homo sapiens_hsa051450.61298781
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.59833359
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59227542
97Phagosome_Homo sapiens_hsa041450.58473459
98Tryptophan metabolism_Homo sapiens_hsa003800.57310647
99Non-small cell lung cancer_Homo sapiens_hsa052230.56662404
100Lysosome_Homo sapiens_hsa041420.55352108
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55087012
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54501428
103Estrogen signaling pathway_Homo sapiens_hsa049150.52631738
104Glutamatergic synapse_Homo sapiens_hsa047240.52242569
105Dorso-ventral axis formation_Homo sapiens_hsa043200.52099079
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.50974684
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50223179
108Leishmaniasis_Homo sapiens_hsa051400.50096373
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49051668
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.48529767
111Insulin resistance_Homo sapiens_hsa049310.48454314
112Prolactin signaling pathway_Homo sapiens_hsa049170.46606266
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46259856
114Ovarian steroidogenesis_Homo sapiens_hsa049130.44916740
115Amphetamine addiction_Homo sapiens_hsa050310.44903818
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.44489438
117Morphine addiction_Homo sapiens_hsa050320.44095052
118Taste transduction_Homo sapiens_hsa047420.43800255
119Salmonella infection_Homo sapiens_hsa051320.43165962
120Tyrosine metabolism_Homo sapiens_hsa003500.42644321
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.42228822
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41940247
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41115084
124Ribosome_Homo sapiens_hsa030100.40746413
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39742295
126Staphylococcus aureus infection_Homo sapiens_hsa051500.39637532
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39263872
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.35914919
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33645187
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33189787
131Malaria_Homo sapiens_hsa051440.31910434
132Glucagon signaling pathway_Homo sapiens_hsa049220.30230562
133Oxidative phosphorylation_Homo sapiens_hsa001900.29661958
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26794384
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25683422
136Alzheimers disease_Homo sapiens_hsa050100.24961751
137Chemical carcinogenesis_Homo sapiens_hsa052040.23708718
138NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22944485
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20169750
140ABC transporters_Homo sapiens_hsa020100.19112126
141Sulfur relay system_Homo sapiens_hsa041220.17181327
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16403814
143Insulin signaling pathway_Homo sapiens_hsa049100.16069876
144Circadian rhythm_Homo sapiens_hsa047100.15763018
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15170215
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.09414565
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08365304
148Metabolic pathways_Homo sapiens_hsa011000.07064580
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.06515102

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