KRT36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)9.40017595
2desmosome organization (GO:0002934)7.59895361
3hemidesmosome assembly (GO:0031581)7.56837701
4bundle of His cell to Purkinje myocyte communication (GO:0086069)7.35887294
5keratinocyte differentiation (GO:0030216)6.83906689
6sarcoplasmic reticulum calcium ion transport (GO:0070296)5.83760869
7establishment of skin barrier (GO:0061436)5.79167442
8intermediate filament organization (GO:0045109)5.67766296
9regulation of water loss via skin (GO:0033561)5.67231907
10regulation of toll-like receptor 4 signaling pathway (GO:0034143)5.09694495
11epidermal cell differentiation (GO:0009913)5.00483735
12regulation of cardioblast proliferation (GO:0003264)4.77595795
13regulation of secondary heart field cardioblast proliferation (GO:0003266)4.77595795
14response to vitamin A (GO:0033189)4.72466219
15epidermis development (GO:0008544)4.71763950
16tooth mineralization (GO:0034505)4.65907406
17regulation of skeletal muscle contraction (GO:0014819)4.51345006
18skeletal muscle contraction (GO:0003009)4.49115937
19muscle organ morphogenesis (GO:0048644)4.41732026
20regulation of relaxation of muscle (GO:1901077)4.36212271
21long-chain fatty acid biosynthetic process (GO:0042759)4.31425708
22actin-myosin filament sliding (GO:0033275)4.21458216
23muscle filament sliding (GO:0030049)4.21458216
24hair follicle morphogenesis (GO:0031069)4.21006655
25purine nucleotide salvage (GO:0032261)4.16783877
26virion attachment to host cell (GO:0019062)4.11908115
27adhesion of symbiont to host cell (GO:0044650)4.11908115
28linoleic acid metabolic process (GO:0043651)4.06951771
29coronary vasculature morphogenesis (GO:0060977)4.06373118
30regulation of skeletal muscle cell differentiation (GO:2001014)4.02159373
31* regulation of keratinocyte differentiation (GO:0045616)3.93312239
32multicellular organismal water homeostasis (GO:0050891)3.88227600
33outer ear morphogenesis (GO:0042473)3.85448561
34lymph vessel development (GO:0001945)3.79018485
35cellular response to epidermal growth factor stimulus (GO:0071364)3.75720659
36ventricular cardiac muscle cell action potential (GO:0086005)3.73708265
37actin-mediated cell contraction (GO:0070252)3.55012701
38hair cycle process (GO:0022405)3.40439130
39molting cycle process (GO:0022404)3.40439130
40innate immune response in mucosa (GO:0002227)3.40209645
41embryonic viscerocranium morphogenesis (GO:0048703)3.38694126
42adhesion of symbiont to host (GO:0044406)3.38185087
43intermediate filament cytoskeleton organization (GO:0045104)3.37110581
44cellular response to retinoic acid (GO:0071300)3.28127126
45intermediate filament-based process (GO:0045103)3.27719225
46water homeostasis (GO:0030104)3.27053996
47skeletal muscle adaptation (GO:0043501)3.24552374
48skin morphogenesis (GO:0043589)3.19386043
49negative regulation of toll-like receptor signaling pathway (GO:0034122)3.18556008
50muscle cell fate commitment (GO:0042693)3.13896258
51intestinal epithelial cell development (GO:0060576)3.12701473
52response to epidermal growth factor (GO:0070849)3.11659146
53regulation of heart rate by cardiac conduction (GO:0086091)3.10379216
54sarcomere organization (GO:0045214)3.08916248
55myotube differentiation (GO:0014902)3.06929376
56citrulline biosynthetic process (GO:0019240)3.05533720
57creatine metabolic process (GO:0006600)3.04971044
58actin filament-based movement (GO:0030048)2.99842242
59O-glycan processing (GO:0016266)2.98675322
60cell communication involved in cardiac conduction (GO:0086065)2.97748588
61hair follicle development (GO:0001942)2.94867337
62regulation of mesenchymal cell apoptotic process (GO:2001053)2.89315606
63cytoskeletal anchoring at plasma membrane (GO:0007016)2.81078060
64lipoxygenase pathway (GO:0019372)2.80894722
65plasma membrane repair (GO:0001778)2.80298979
66cell-substrate junction assembly (GO:0007044)2.76185547
67outflow tract septum morphogenesis (GO:0003148)2.75933605
68positive regulation of protein depolymerization (GO:1901881)2.72496920
69negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.72401421
70positive regulation of myotube differentiation (GO:0010831)2.72348193
71mucosal immune response (GO:0002385)2.69434192
72* regulation of epidermal cell differentiation (GO:0045604)2.68149691
73negative regulation of thymocyte apoptotic process (GO:0070244)2.66209507
74cardiac conduction (GO:0061337)2.66170828
75mucosal-associated lymphoid tissue development (GO:0048537)2.63079967
76Peyers patch development (GO:0048541)2.63079967
77positive regulation of monocyte chemotaxis (GO:0090026)2.62517291
78phosphatidylserine acyl-chain remodeling (GO:0036150)2.58869373
79striated muscle contraction (GO:0006941)2.58330253
80regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.58076154
81prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.56270840
82skin development (GO:0043588)2.53806401
83organ or tissue specific immune response (GO:0002251)2.53129778
84transcytosis (GO:0045056)2.50722827
85cranial nerve morphogenesis (GO:0021602)2.50671504
86cardiac muscle cell action potential involved in contraction (GO:0086002)2.49515163
87cellular response to glucocorticoid stimulus (GO:0071385)2.49453505
88tricarboxylic acid cycle (GO:0006099)2.44854631
89maintenance of gastrointestinal epithelium (GO:0030277)2.44417173
90response to muscle activity (GO:0014850)2.42832174
91cardiac muscle cell action potential (GO:0086001)2.40867580
92wound healing (GO:0042060)2.39804483
93ectoderm development (GO:0007398)2.39681425
94phosphatidylinositol acyl-chain remodeling (GO:0036149)2.39186761
95keratinization (GO:0031424)19.0414557
96hair cycle (GO:0042633)12.8842230
97molting cycle (GO:0042303)12.8842230
98cell wall macromolecule catabolic process (GO:0016998)11.9526766
99cell wall macromolecule metabolic process (GO:0044036)11.9526766
100peptide cross-linking (GO:0018149)10.1633467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF652_21678463_ChIP-ChIP_ZR75-1_Human4.59843708
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.34190697
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.04858016
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.74951905
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.73935926
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.63455959
7P63_26484246_Chip-Seq_KERATINOCYTES_Human2.34546526
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.33336611
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23407573
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.18817707
11ZNF263_19887448_ChIP-Seq_K562_Human2.08640036
12TP63_17297297_ChIP-ChIP_HaCaT_Human11.6886502
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97065139
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96040021
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.75349727
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72286360
17* CTCF_20526341_ChIP-Seq_ESCs_Human1.71224597
18CDX2_20551321_ChIP-Seq_CACO-2_Human1.70883841
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69181632
20SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69181632
21CTCF_27219007_Chip-Seq_Bcells_Human1.65559001
22SOX2_20726797_ChIP-Seq_SW620_Human1.65245332
23* RACK7_27058665_Chip-Seq_MCF-7_Human1.59332839
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58070369
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.55181006
26ERG_20517297_ChIP-Seq_VCAP_Human1.53663037
27CLOCK_20551151_ChIP-Seq_293T_Human1.51902916
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48746921
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48509430
30* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44657837
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35907719
32KLF5_25053715_ChIP-Seq_YYC3_Human1.32559674
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.30464615
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27723121
35SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27373847
36CJUN_26792858_Chip-Seq_BT549_Human1.26212553
37ATF3_27146783_Chip-Seq_COLON_Human1.25437886
38EGR1_19032775_ChIP-ChIP_M12_Human1.24063722
39GATA3_24758297_ChIP-Seq_MCF-7_Human1.22620537
40TP63_22573176_ChIP-Seq_HFKS_Human1.17835370
41GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.16786104
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15523760
43GATA4_25053715_ChIP-Seq_YYC3_Human1.14313903
44* NANOG_20526341_ChIP-Seq_ESCs_Human1.14304876
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13706037
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12420082
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11652064
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10292354
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09738038
50LXR_22292898_ChIP-Seq_THP-1_Human1.09627003
51GATA6_25053715_ChIP-Seq_YYC3_Human1.08407157
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08291780
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07350407
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.02310964
55GATA6_21074721_ChIP-Seq_CACO-2_Human1.01424233
56RXR_22108803_ChIP-Seq_LS180_Human1.01261483
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01186871
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01067861
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00460853
60* BCOR_27268052_Chip-Seq_Bcells_Human0.99882776
61ELK3_25401928_ChIP-Seq_HUVEC_Human0.99731406
62JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99272153
63TP63_23658742_ChIP-Seq_EP156T_Human0.97998282
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97794648
65BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96654648
66PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96644707
67CSB_26484114_Chip-Seq_FIBROBLAST_Human0.96441484
68* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96252711
69CEBPB_22108803_ChIP-Seq_LS180_Human0.96071033
70TBX20_22080862_ChIP-Seq_HEART_Mouse0.92999259
71TBX20_22328084_ChIP-Seq_HEART_Mouse0.92999259
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92897853
73FOXH1_21741376_ChIP-Seq_ESCs_Human0.92633488
74STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91884610
75E2F1_20622854_ChIP-Seq_HELA_Human0.91680995
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91301431
77ERG_21242973_ChIP-ChIP_JURKAT_Human0.90136961
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89936586
79SMC4_20622854_ChIP-Seq_HELA_Human0.89306673
80P53_21459846_ChIP-Seq_SAOS-2_Human0.89176124
81SA1_27219007_Chip-Seq_ERYTHROID_Human0.88635060
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87922849
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87696121
84* P68_20966046_ChIP-Seq_HELA_Human0.86840190
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86511056
86P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.86215174
87SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85311765
88AHR_22903824_ChIP-Seq_MCF-7_Human0.84607764
89* BCL6_27268052_Chip-Seq_Bcells_Human0.83325456
90LXR_22158963_ChIP-Seq_LIVER_Mouse0.83037401
91TP53_20018659_ChIP-ChIP_R1E_Mouse0.81308325
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80080513
93OCT1_27270436_Chip-Seq_PROSTATE_Human0.79913880
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.79296150
95TAF2_19829295_ChIP-Seq_ESCs_Human0.78261812
96BCAT_22108803_ChIP-Seq_LS180_Human0.78018758
97SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77866567
98KDM2B_26808549_Chip-Seq_K562_Human0.76060151
99KDM2B_26808549_Chip-Seq_DND41_Human0.75352955
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.75030479

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.99281861
2MP0010234_abnormal_vibrissa_follicle5.72237092
3MP0005275_abnormal_skin_tensile5.50846770
4MP0002234_abnormal_pharynx_morphology4.57640664
5MP0000579_abnormal_nail_morphology3.99072968
6MP0005501_abnormal_skin_physiology3.69873390
7MP0002098_abnormal_vibrissa_morphology3.43623942
8MP0000647_abnormal_sebaceous_gland3.30832424
9MP0003705_abnormal_hypodermis_morpholog3.29076185
10MP0000467_abnormal_esophagus_morphology3.13899566
11MP0000751_myopathy2.95165079
12MP0000762_abnormal_tongue_morphology2.85814567
13MP0010678_abnormal_skin_adnexa2.82901722
14MP0003646_muscle_fatigue2.56346173
15MP0000383_abnormal_hair_follicle2.54658882
16MP0004185_abnormal_adipocyte_glucose2.33867724
17MP0001216_abnormal_epidermal_layer2.28998975
18MP0001243_abnormal_dermal_layer2.18042417
19MP0002254_reproductive_system_inflammat2.17949781
20MP0000377_abnormal_hair_follicle2.14798913
21MP0010771_integument_phenotype2.11680898
22MP0000749_muscle_degeneration2.10862670
23MP0000427_abnormal_hair_cycle2.08688893
24MP0003453_abnormal_keratinocyte_physiol2.07097722
25MP0002060_abnormal_skin_morphology2.05968891
26MP0004264_abnormal_extraembryonic_tissu1.86579105
27MP0004947_skin_inflammation1.86159438
28MP0004130_abnormal_muscle_cell1.75958417
29MP0002837_dystrophic_cardiac_calcinosis1.71221261
30MP0000747_muscle_weakness1.64982458
31MP0003566_abnormal_cell_adhesion1.53665204
32MP0001849_ear_inflammation1.51778247
33MP0002106_abnormal_muscle_physiology1.37765737
34MP0005666_abnormal_adipose_tissue1.36551307
35MP0000759_abnormal_skeletal_muscle1.36170153
36MP0000367_abnormal_coat/_hair1.34978037
37MP0002095_abnormal_skin_pigmentation1.32471643
38MP0004087_abnormal_muscle_fiber1.29624086
39MP0000733_abnormal_muscle_development1.26523079
40MP0009931_abnormal_skin_appearance1.24953250
41MP0004145_abnormal_muscle_electrophysio1.24812437
42MP0000678_abnormal_parathyroid_gland1.24483908
43MP0002249_abnormal_larynx_morphology1.22777366
44MP0003252_abnormal_bile_duct1.18922175
45MP0000537_abnormal_urethra_morphology1.18666235
46MP0000750_abnormal_muscle_regeneration1.11143556
47MP0006054_spinal_hemorrhage1.05416463
48MP0005369_muscle_phenotype1.02292873
49MP0005248_abnormal_Harderian_gland1.02014102
50MP0010030_abnormal_orbit_morphology1.01989576
51MP0009053_abnormal_anal_canal1.00285588
52MP0004036_abnormal_muscle_relaxation0.97709188
53MP0002269_muscular_atrophy0.94262383
54MP0005620_abnormal_muscle_contractility0.93884342
55MP0000470_abnormal_stomach_morphology0.92933488
56MP0000462_abnormal_digestive_system0.91824179
57MP0001191_abnormal_skin_condition0.91404605
58MP0005451_abnormal_body_composition0.89536771
59MP0005187_abnormal_penis_morphology0.87898823
60MP0005375_adipose_tissue_phenotype0.85634874
61MP0001879_abnormal_lymphatic_vessel0.83775053
62MP0010352_gastrointestinal_tract_polyps0.82676617
63MP0003941_abnormal_skin_development0.82432969
64MP0003950_abnormal_plasma_membrane0.79260703
65MP0004272_abnormal_basement_membrane0.78133067
66MP0002971_abnormal_brown_adipose0.76245176
67MP0000465_gastrointestinal_hemorrhage0.75993196
68MP0002909_abnormal_adrenal_gland0.75881957
69MP0005330_cardiomyopathy0.74516560
70MP0002332_abnormal_exercise_endurance0.74101793
71MP0004484_altered_response_of0.73755214
72MP0002972_abnormal_cardiac_muscle0.70563116
73MP0009697_abnormal_copulation0.69764932
74MP0000371_diluted_coat_color0.68207713
75MP0006036_abnormal_mitochondrial_physio0.66524596
76MP0004270_analgesia0.55999625
77MP0003045_fibrosis0.55900130
78MP0001346_abnormal_lacrimal_gland0.54217992
79MP0005023_abnormal_wound_healing0.48985219
80MP0004381_abnormal_hair_follicle0.47537704
81MP0000613_abnormal_salivary_gland0.46569552
82MP0002877_abnormal_melanocyte_morpholog0.46155762
83MP0005381_digestive/alimentary_phenotyp0.45934644
84MP0008438_abnormal_cutaneous_collagen0.45904272
85MP0001666_abnormal_nutrient_absorption0.44724923
86MP0000566_synostosis0.42589632
87MP0004084_abnormal_cardiac_muscle0.42473231
88MP0003315_abnormal_perineum_morphology0.42469346
89MP0001784_abnormal_fluid_regulation0.42146465
90MP0010630_abnormal_cardiac_muscle0.41352349
91MP0003755_abnormal_palate_morphology0.41230672
92MP0000538_abnormal_urinary_bladder0.39536371
93MP0005266_abnormal_metabolism0.38957748
94MP0001663_abnormal_digestive_system0.38320361
95MP0002282_abnormal_trachea_morphology0.37093994
96MP0001544_abnormal_cardiovascular_syste0.37057217
97MP0005385_cardiovascular_system_phenoty0.37057217
98MP0003191_abnormal_cellular_cholesterol0.36987745
99MP0003075_altered_response_to0.36980453
100MP0003329_amyloid_beta_deposits0.36194115

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)8.79376208
2Hypotrichosis (HP:0001006)6.45188051
3Woolly hair (HP:0002224)6.28976084
4Right ventricular cardiomyopathy (HP:0011663)6.24124202
5Onycholysis (HP:0001806)5.86527245
6Distal arthrogryposis (HP:0005684)5.07972926
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.95503049
8Muscle fiber inclusion bodies (HP:0100299)4.94144310
9Fragile nails (HP:0001808)4.79186536
10Exercise-induced myalgia (HP:0003738)4.69578486
11Increased IgE level (HP:0003212)4.61272601
12Nemaline bodies (HP:0003798)4.54854187
13Round ear (HP:0100830)4.50431399
14Pili torti (HP:0003777)4.46681839
15Increased connective tissue (HP:0009025)4.32461039
16Milia (HP:0001056)4.27068365
17Absent phalangeal crease (HP:0006109)4.23783430
18Type 1 muscle fiber predominance (HP:0003803)4.18635489
19Ulnar deviation of the wrist (HP:0003049)4.10405583
20Nail dystrophy (HP:0008404)4.08188410
21Exercise-induced muscle cramps (HP:0003710)3.96587110
22Myopathic facies (HP:0002058)3.84782038
23Calcaneovalgus deformity (HP:0001848)3.71070366
24Plantar hyperkeratosis (HP:0007556)3.68247184
25Difficulty running (HP:0009046)3.57805354
26Hyporeflexia of lower limbs (HP:0002600)3.53843670
27Facial diplegia (HP:0001349)3.50151270
28Abnormal finger flexion creases (HP:0006143)3.47943440
29Unilateral renal agenesis (HP:0000122)3.39949046
30Atrophic scars (HP:0001075)3.39607787
31Slow-growing hair (HP:0002217)3.36656761
32Abnormality of hair growth rate (HP:0011363)3.36656761
33Myoglobinuria (HP:0002913)3.35981323
34Deformed tarsal bones (HP:0008119)3.28173827
35Congenital ichthyosiform erythroderma (HP:0007431)3.27886382
36Rimmed vacuoles (HP:0003805)3.22976101
37Muscle fiber splitting (HP:0003555)3.22323457
38Muscle hypertrophy of the lower extremities (HP:0008968)3.21220964
39Calf muscle hypertrophy (HP:0008981)3.12680481
40Brittle hair (HP:0002299)3.01673838
41Abnormality of the aortic arch (HP:0012303)3.01152417
42Neck muscle weakness (HP:0000467)2.97869889
43EMG: myopathic abnormalities (HP:0003458)2.91887460
44Increased variability in muscle fiber diameter (HP:0003557)2.90653957
45Distal lower limb muscle weakness (HP:0009053)2.90318408
46Autoimmune thrombocytopenia (HP:0001973)2.89966500
47Abnormality of skeletal muscle fiber size (HP:0012084)2.89117031
48Abnormality of nail color (HP:0100643)2.83836646
49Distal lower limb amyotrophy (HP:0008944)2.69564545
50Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.62379392
51Abnormal hair laboratory examination (HP:0003328)2.61320358
52Congenital malformation of the right heart (HP:0011723)2.52482134
53Double outlet right ventricle (HP:0001719)2.52482134
54Abnormality of the calcaneus (HP:0008364)2.49739774
55Ectropion (HP:0000656)2.49157693
56Palmoplantar hyperkeratosis (HP:0000972)2.46006335
57Ventricular tachycardia (HP:0004756)2.42377922
58Alopecia of scalp (HP:0002293)2.37401600
59Cholelithiasis (HP:0001081)2.35578138
60Mesangial abnormality (HP:0001966)2.34207218
61Rhabdomyolysis (HP:0003201)2.33456275
62Muscle stiffness (HP:0003552)2.33036814
63Difficulty climbing stairs (HP:0003551)2.27785491
64Palmar hyperkeratosis (HP:0010765)2.25303231
65Palmoplantar keratoderma (HP:0000982)2.18955508
66Myotonia (HP:0002486)2.18140677
67Abnormality of the calf musculature (HP:0001430)2.17833623
68Autoimmune hemolytic anemia (HP:0001890)2.15385274
69Abnormality of the parathyroid morphology (HP:0011766)2.15169241
70Areflexia of lower limbs (HP:0002522)2.14218309
71Mildly elevated creatine phosphokinase (HP:0008180)2.12744929
72Abnormal gallbladder morphology (HP:0012437)2.11810879
73Frequent falls (HP:0002359)2.08364218
74Hyperthyroidism (HP:0000836)2.08245646
75Conjunctival hamartoma (HP:0100780)2.04675846
76Cupped ribs (HP:0000887)2.03269464
77Corneal erosion (HP:0200020)2.02591479
78Lower limb amyotrophy (HP:0007210)2.01404376
79Palpitations (HP:0001962)1.97712804
80Ulnar deviation of finger (HP:0009465)1.97034505
81Paralysis (HP:0003470)1.95931988
82Thick nail (HP:0001805)1.93126145
83Abnormal blistering of the skin (HP:0008066)1.90524584
84Pruritus (HP:0000989)1.83483467
85Congenital, generalized hypertrichosis (HP:0004540)1.82513596
86Curly hair (HP:0002212)1.76310984
87Follicular hyperkeratosis (HP:0007502)1.76297006
88Ventricular fibrillation (HP:0001663)1.75887006
89Achilles tendon contracture (HP:0001771)1.75042923
90Aplasia cutis congenita (HP:0001057)1.74771529
91Scapular winging (HP:0003691)1.73071207
92Fragile skin (HP:0001030)1.67556143
93Limb-girdle muscle atrophy (HP:0003797)1.67101648
94Tetany (HP:0001281)1.65889934
95Abnormality of the Achilles tendon (HP:0005109)1.63200164
96Gangrene (HP:0100758)1.59899866
97Advanced eruption of teeth (HP:0006288)1.59815334
98Sudden death (HP:0001699)1.59470795
99Exotropia (HP:0000577)1.59181834
100Amelogenesis imperfecta (HP:0000705)1.58626817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN7.75388022
2PIK3CG3.73241227
3EPHA23.50242275
4TRIB33.46344519
5MST1R2.66234843
6OBSCN2.51577217
7FER2.40373265
8PKN22.18911288
9NEK12.12494719
10MAPKAPK32.10600039
11NME12.04715206
12PHKG22.01441133
13PHKG12.01441133
14TAOK11.96591619
15LATS11.82192550
16MST41.81936888
17MAP2K31.75720208
18KSR21.68769527
19PDK41.68191648
20PDK31.68191648
21PIK3CA1.55765680
22EPHB21.53542483
23RIPK11.50594531
24PTK61.42559271
25MAP2K21.41291264
26ERN11.35093087
27DMPK1.33795345
28MAP3K71.31868870
29MAP3K21.31023459
30MAP3K31.30865801
31MAP2K11.24916359
32RPS6KB21.20380180
33EPHB11.16336921
34MAP3K91.12755202
35MAP3K11.09387090
36MAP2K61.08339958
37MAP3K61.07632372
38LRRK21.07052968
39EEF2K1.04640428
40MET1.03233940
41PDK21.02569140
42TESK10.98314987
43MAP3K110.93186433
44LATS20.91836204
45LIMK10.90230360
46FRK0.86796739
47PAK40.85126289
48TRPM70.78100766
49BCKDK0.78094627
50SIK10.75743787
51MAP2K40.75430032
52CDK60.70654825
53PRKD10.70498320
54PINK10.69920199
55PTK20.65959744
56FGFR30.64028578
57LMTK20.63085943
58BMX0.62292368
59MAPK110.62079838
60PDGFRA0.61695171
61FGFR40.58168233
62PAK30.57707959
63MAPK120.56126083
64FGFR10.54866914
65PRKAA20.54678840
66DDR20.54235372
67DYRK1B0.52714339
68PRKG20.50291858
69MAP3K80.48959977
70ERBB30.47425927
71STK100.45091212
72RET0.43659339
73ALK0.41400800
74ERBB20.41224254
75MAP3K100.40805835
76MAP3K120.38278607
77KSR10.36887775
78PDPK10.36181733
79CAMK2A0.35966308
80EPHA30.34783225
81ERBB40.34015333
82MAPKAPK20.33761966
83ILK0.33071041
84CAMK2G0.32107107
85PRKCI0.28789817
86STK30.28551820
87PAK60.27951779
88PDK10.25405837
89SGK10.24884949
90AKT20.23713982
91ROCK20.23211704
92MAP3K130.22414133
93MOS0.22066987
94ICK0.21229258
95RPS6KA10.20527936
96TGFBR20.20128972
97PRKG10.16998719
98CAMKK10.16484886
99SRC0.16088122
100PRKAA10.14788970

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.91623958
2Salivary secretion_Homo sapiens_hsa049703.73500894
3Phenylalanine metabolism_Homo sapiens_hsa003603.65505361
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.85963844
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30340317
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.23806961
7Glycerolipid metabolism_Homo sapiens_hsa005612.18980017
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.18829475
9Histidine metabolism_Homo sapiens_hsa003402.17185003
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.00416260
11beta-Alanine metabolism_Homo sapiens_hsa004101.93522168
12Tyrosine metabolism_Homo sapiens_hsa003501.79736475
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79655941
14Linoleic acid metabolism_Homo sapiens_hsa005911.64560739
15Fatty acid degradation_Homo sapiens_hsa000711.57519212
16Propanoate metabolism_Homo sapiens_hsa006401.52531964
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49641058
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30444676
19Carbon metabolism_Homo sapiens_hsa012001.27317623
20Arachidonic acid metabolism_Homo sapiens_hsa005901.22269808
21GnRH signaling pathway_Homo sapiens_hsa049121.16860742
22Fatty acid metabolism_Homo sapiens_hsa012121.16196632
23Tight junction_Homo sapiens_hsa045301.14685047
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13241725
25Nitrogen metabolism_Homo sapiens_hsa009101.12882920
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11969402
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08648043
28Dilated cardiomyopathy_Homo sapiens_hsa054141.07160612
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06156652
30Sulfur metabolism_Homo sapiens_hsa009201.04537622
31ECM-receptor interaction_Homo sapiens_hsa045121.00317505
32PPAR signaling pathway_Homo sapiens_hsa033200.99932146
33Chemical carcinogenesis_Homo sapiens_hsa052040.98692563
34VEGF signaling pathway_Homo sapiens_hsa043700.98378657
35Gastric acid secretion_Homo sapiens_hsa049710.96246237
36Glucagon signaling pathway_Homo sapiens_hsa049220.95347348
37Alzheimers disease_Homo sapiens_hsa050100.93701098
38Arginine biosynthesis_Homo sapiens_hsa002200.93628649
39Cardiac muscle contraction_Homo sapiens_hsa042600.90582103
40Thyroid cancer_Homo sapiens_hsa052160.90076945
41Renin secretion_Homo sapiens_hsa049240.89414422
42Amoebiasis_Homo sapiens_hsa051460.88937314
43Adherens junction_Homo sapiens_hsa045200.87125620
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.86813937
45Starch and sucrose metabolism_Homo sapiens_hsa005000.83446715
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81464484
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81118654
48Insulin signaling pathway_Homo sapiens_hsa049100.80494943
49Insulin resistance_Homo sapiens_hsa049310.80234863
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79161658
51Butanoate metabolism_Homo sapiens_hsa006500.76095836
52Ether lipid metabolism_Homo sapiens_hsa005650.75454514
53Focal adhesion_Homo sapiens_hsa045100.73803919
54Fatty acid elongation_Homo sapiens_hsa000620.73544403
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72382827
56Melanogenesis_Homo sapiens_hsa049160.71947631
57Pyruvate metabolism_Homo sapiens_hsa006200.71823415
58Biosynthesis of amino acids_Homo sapiens_hsa012300.71213303
59Oxytocin signaling pathway_Homo sapiens_hsa049210.71098576
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.70890718
61Bladder cancer_Homo sapiens_hsa052190.69880707
62Long-term potentiation_Homo sapiens_hsa047200.69477270
63Glioma_Homo sapiens_hsa052140.69075290
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68831160
65Proteoglycans in cancer_Homo sapiens_hsa052050.68611349
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67356118
67Pertussis_Homo sapiens_hsa051330.64472275
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63096770
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.59705777
70Pancreatic secretion_Homo sapiens_hsa049720.59076856
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.58812575
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58198537
73Dorso-ventral axis formation_Homo sapiens_hsa043200.57771181
74Toxoplasmosis_Homo sapiens_hsa051450.55285630
75Caffeine metabolism_Homo sapiens_hsa002320.54394857
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52937369
77Estrogen signaling pathway_Homo sapiens_hsa049150.52234528
78Long-term depression_Homo sapiens_hsa047300.52074075
79Endometrial cancer_Homo sapiens_hsa052130.51736770
80Hippo signaling pathway_Homo sapiens_hsa043900.50484953
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50412862
82Salmonella infection_Homo sapiens_hsa051320.50410883
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47432459
84AMPK signaling pathway_Homo sapiens_hsa041520.47049106
85Fatty acid biosynthesis_Homo sapiens_hsa000610.46863420
86Phototransduction_Homo sapiens_hsa047440.45968289
87Basal cell carcinoma_Homo sapiens_hsa052170.44791339
88Olfactory transduction_Homo sapiens_hsa047400.44491454
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42264511
90Parkinsons disease_Homo sapiens_hsa050120.41930519
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40719555
92Small cell lung cancer_Homo sapiens_hsa052220.40679907
93Platelet activation_Homo sapiens_hsa046110.40491506
94Calcium signaling pathway_Homo sapiens_hsa040200.40025220
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39659145
96Bile secretion_Homo sapiens_hsa049760.37122178
97Circadian entrainment_Homo sapiens_hsa047130.37034964
98Oxidative phosphorylation_Homo sapiens_hsa001900.35388518
99Mineral absorption_Homo sapiens_hsa049780.35005467
100Tryptophan metabolism_Homo sapiens_hsa003800.33300429

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