KRT39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1virion attachment to host cell (GO:0019062)9.08927382
2adhesion of symbiont to host cell (GO:0044650)9.08927382
3citrulline biosynthetic process (GO:0019240)7.61876863
4peptide cross-linking (GO:0018149)7.56763044
5adhesion of symbiont to host (GO:0044406)7.50320413
6hair follicle morphogenesis (GO:0031069)6.30083373
7bundle of His cell to Purkinje myocyte communication (GO:0086069)6.27318873
8establishment of skin barrier (GO:0061436)6.10709320
9keratinocyte differentiation (GO:0030216)5.93673465
10intermediate filament cytoskeleton organization (GO:0045104)5.85367510
11intermediate filament-based process (GO:0045103)5.68215111
12hemidesmosome assembly (GO:0031581)5.66392226
13regulation of water loss via skin (GO:0033561)5.38007829
14epidermis development (GO:0008544)5.36523383
15cell wall macromolecule catabolic process (GO:0016998)5.05847238
16cell wall macromolecule metabolic process (GO:0044036)5.05847238
17citrulline metabolic process (GO:0000052)5.01917416
18molting cycle process (GO:0022404)4.53569566
19hair cycle process (GO:0022405)4.53569566
20epidermal cell differentiation (GO:0009913)4.49953412
21regulation of apoptotic process involved in morphogenesis (GO:1902337)4.42062687
22skin morphogenesis (GO:0043589)4.31851971
23regulation of mesenchymal cell apoptotic process (GO:2001053)4.30082325
24negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.24435218
25nephron tubule formation (GO:0072079)3.94707774
26ventricular cardiac muscle cell action potential (GO:0086005)3.74157949
27peptidyl-arginine modification (GO:0018195)3.68790536
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66839877
29nephron tubule development (GO:0072080)3.54989774
30multicellular organismal water homeostasis (GO:0050891)3.53694049
31outflow tract septum morphogenesis (GO:0003148)3.49038543
32embryonic retina morphogenesis in camera-type eye (GO:0060059)3.48329329
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47245866
34ATP synthesis coupled proton transport (GO:0015986)3.47245866
35negative regulation of metanephros development (GO:0072217)3.44004013
36regulation of cell fate specification (GO:0042659)3.41837655
37cardiac right ventricle morphogenesis (GO:0003215)3.39884153
38phosphatidylinositol acyl-chain remodeling (GO:0036149)3.30222590
39phosphatidylserine acyl-chain remodeling (GO:0036150)3.13145578
40respiratory electron transport chain (GO:0022904)3.12654999
41hair follicle development (GO:0001942)3.12618229
42renal tubule development (GO:0061326)3.11653154
43otic vesicle formation (GO:0030916)3.06214363
44auditory receptor cell differentiation (GO:0042491)3.04768996
45gap junction assembly (GO:0016264)3.04463029
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02201815
47cell surface receptor signaling pathway involved in heart development (GO:0061311)3.02020937
48electron transport chain (GO:0022900)3.01848025
49molting cycle (GO:0042303)27.3984585
50hair cycle (GO:0042633)27.3984585
51epithelium development (GO:0060429)2.91419562
52negative regulation of cell fate specification (GO:0009996)2.87834244
53regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.83479649
54keratinocyte development (GO:0003334)2.82818986
55atrioventricular valve morphogenesis (GO:0003181)2.81198181
56tooth mineralization (GO:0034505)2.79299128
57water homeostasis (GO:0030104)2.77120165
58nephron epithelium development (GO:0072009)2.75490731
59negative regulation of keratinocyte proliferation (GO:0010839)2.73200218
60ectoderm development (GO:0007398)2.66356595
61neural crest cell development (GO:0014032)2.63077602
62regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.59555435
63Notch signaling involved in heart development (GO:0061314)2.57874140
64regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.55716147
65regulation of keratinocyte differentiation (GO:0045616)2.53663932
66regulation of heart rate by cardiac conduction (GO:0086091)2.47113378
67neuronal stem cell maintenance (GO:0097150)2.42348520
68epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.42136561
69phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.41622225
70regulation of cardioblast differentiation (GO:0051890)2.40684024
71head development (GO:0060322)2.39403962
72negative regulation of kidney development (GO:0090185)2.39357134
73negative regulation of stem cell differentiation (GO:2000737)2.37872806
74negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.37060480
75cell communication involved in cardiac conduction (GO:0086065)2.36581350
76urogenital system development (GO:0001655)2.36080880
77nephron tubule morphogenesis (GO:0072078)2.34293594
78nephron epithelium morphogenesis (GO:0072088)2.34293594
79heart valve morphogenesis (GO:0003179)2.33261149
80negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.32228273
81negative regulation of epidermis development (GO:0045683)2.31708142
82embryonic viscerocranium morphogenesis (GO:0048703)2.29522236
83cardiac muscle cell action potential involved in contraction (GO:0086002)2.27808600
84positive regulation of gastrulation (GO:2000543)2.26779141
85regulation of hair follicle development (GO:0051797)2.26314761
86cardiac conduction (GO:0061337)2.25758977
87positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.25280743
88regulation of mesonephros development (GO:0061217)2.23431479
89keratinocyte proliferation (GO:0043616)2.22056700
90regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.21626054
91morphogenesis of an epithelial sheet (GO:0002011)2.21334323
92regulation of stem cell maintenance (GO:2000036)2.19811297
93bone trabecula formation (GO:0060346)2.19476512
94regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.18342921
95planar cell polarity pathway involved in neural tube closure (GO:0090179)2.18244101
96cardiac muscle cell action potential (GO:0086001)2.18202910
97non-canonical Wnt signaling pathway (GO:0035567)2.15986437
98keratinization (GO:0031424)11.0235920
99intermediate filament organization (GO:0045109)10.4249183
100desmosome organization (GO:0002934)10.0760104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.93234039
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.90916501
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.21366799
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70434954
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.50064683
6TP63_17297297_ChIP-ChIP_HaCaT_Human14.4010659
7BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.98093697
8FOXO3_23340844_ChIP-Seq_DLD1_Human1.94665953
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83684800
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.78929925
11CTCF_20526341_ChIP-Seq_ESCs_Human1.73241692
12RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70214768
13EGR1_19032775_ChIP-ChIP_M12_Human1.62962583
14SOX9_24532713_ChIP-Seq_HFSC_Mouse1.61394316
15NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.59731899
16SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56734359
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56734359
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.48751561
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46560378
20P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.46103176
21GATA4_25053715_ChIP-Seq_YYC3_Human1.44516732
22ATF3_27146783_Chip-Seq_COLON_Human1.43905921
23E2F1_20622854_ChIP-Seq_HELA_Human1.43586334
24NANOG_20526341_ChIP-Seq_ESCs_Human1.39603877
25* TAF2_19829295_ChIP-Seq_ESCs_Human1.34456985
26ZNF263_19887448_ChIP-Seq_K562_Human1.31889620
27UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30162549
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.29718380
29ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29131149
30CSB_26484114_Chip-Seq_FIBROBLAST_Human1.28900099
31GATA3_24758297_ChIP-Seq_MCF-7_Human1.28629852
32CTCF_27219007_Chip-Seq_Bcells_Human1.28543017
33RACK7_27058665_Chip-Seq_MCF-7_Human1.26387707
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25590699
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.25038676
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.22171000
37TP63_22573176_ChIP-Seq_HFKS_Human1.21208841
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.19176278
39SOX2_20726797_ChIP-Seq_SW620_Human1.18219349
40P53_21459846_ChIP-Seq_SAOS-2_Human1.18048011
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17075779
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16757932
43YY1_22570637_ChIP-Seq_MALME-3M_Human1.16401665
44* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.15200135
45ERG_20517297_ChIP-Seq_VCAP_Human1.15156280
46TP63_23658742_ChIP-Seq_EP156T_Human1.13413640
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10398910
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.07237238
49UBF1/2_26484160_Chip-Seq_HMECs_Human1.06014352
50* BCL6_27268052_Chip-Seq_Bcells_Human1.04768541
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04432969
52KLF5_25053715_ChIP-Seq_YYC3_Human1.04183649
53* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03981283
54BCOR_27268052_Chip-Seq_Bcells_Human1.03341603
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03230226
56RXR_22108803_ChIP-Seq_LS180_Human1.02763259
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02047040
58SPI1_20517297_ChIP-Seq_HL60_Human1.01236673
59CEBPB_22108803_ChIP-Seq_LS180_Human1.00285536
60AR_21572438_ChIP-Seq_LNCaP_Human0.98078398
61AHR_22903824_ChIP-Seq_MCF-7_Human0.97412235
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97366838
63GATA6_25053715_ChIP-Seq_YYC3_Human0.96972091
64ESR1_20079471_ChIP-ChIP_T-47D_Human0.96635561
65RING1B_27294783_Chip-Seq_ESCs_Mouse0.96492069
66ARNT_22903824_ChIP-Seq_MCF-7_Human0.96119504
67CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95759622
68TP53_18474530_ChIP-ChIP_U2OS_Human0.95175352
69TBX20_22328084_ChIP-Seq_HEART_Mouse0.93306932
70TBX20_22080862_ChIP-Seq_HEART_Mouse0.93306932
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93157243
72BCAT_22108803_ChIP-Seq_LS180_Human0.91441846
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87813028
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87795230
75ERG_21242973_ChIP-ChIP_JURKAT_Human0.86911353
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85129366
77CLOCK_20551151_ChIP-Seq_293T_Human0.84570522
78RAC3_21632823_ChIP-Seq_H3396_Human0.84301866
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84052905
80JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83802507
81RUNX1_27514584_Chip-Seq_MCF-7_Human0.83647515
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80884457
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80710992
84EZH2_27304074_Chip-Seq_ESCs_Mouse0.80069470
85LXR_22292898_ChIP-Seq_THP-1_Human0.80056579
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79758687
87RNF2_27304074_Chip-Seq_ESCs_Mouse0.78601607
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78399025
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.77564479
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77564479
91PHF8_20622854_ChIP-Seq_HELA_Human0.77055237
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.77010193
93SMC4_20622854_ChIP-Seq_HELA_Human0.76751261
94E2F1_17053090_ChIP-ChIP_MCF-7_Human0.76572141
95SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76365322
96PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76321883
97RNF2_18974828_ChIP-Seq_MESCs_Mouse0.76159171
98EZH2_18974828_ChIP-Seq_MESCs_Mouse0.76159171
99EZH2_27294783_Chip-Seq_ESCs_Mouse0.73955760
100P68_20966046_ChIP-Seq_HELA_Human0.73583462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.67668512
2MP0002098_abnormal_vibrissa_morphology5.81952074
3MP0002796_impaired_skin_barrier5.45174633
4MP0005275_abnormal_skin_tensile5.28102549
5MP0000647_abnormal_sebaceous_gland5.19224640
6MP0000383_abnormal_hair_follicle4.77156625
7MP0010678_abnormal_skin_adnexa4.17676063
8MP0010234_abnormal_vibrissa_follicle3.98923611
9MP0000377_abnormal_hair_follicle3.43750954
10MP0005501_abnormal_skin_physiology3.28310157
11MP0005083_abnormal_biliary_tract3.18314380
12MP0000427_abnormal_hair_cycle3.11071107
13MP0002139_abnormal_hepatobiliary_system2.76583043
14MP0003705_abnormal_hypodermis_morpholog2.74921828
15MP0002254_reproductive_system_inflammat2.51362739
16MP0001216_abnormal_epidermal_layer2.32557509
17MP0005084_abnormal_gallbladder_morpholo2.30576285
18MP0002138_abnormal_hepatobiliary_system2.15833188
19MP0010771_integument_phenotype2.11465703
20MP0004947_skin_inflammation2.02671659
21MP0005085_abnormal_gallbladder_physiolo2.02037255
22MP0004381_abnormal_hair_follicle1.99688998
23MP0002928_abnormal_bile_duct1.91717451
24MP0003941_abnormal_skin_development1.89401527
25MP0002060_abnormal_skin_morphology1.85645576
26MP0000367_abnormal_coat/_hair1.83830945
27MP0001243_abnormal_dermal_layer1.71580673
28MP0003453_abnormal_keratinocyte_physiol1.67736920
29MP0000467_abnormal_esophagus_morphology1.62629883
30MP0005409_darkened_coat_color1.62316760
31MP0000762_abnormal_tongue_morphology1.49466006
32MP0010030_abnormal_orbit_morphology1.37325375
33MP0001849_ear_inflammation1.31425055
34MP0009379_abnormal_foot_pigmentation1.29309364
35MP0002234_abnormal_pharynx_morphology1.27733601
36MP0009931_abnormal_skin_appearance1.21118193
37MP0003566_abnormal_cell_adhesion1.19651100
38MP0009053_abnormal_anal_canal1.14875373
39MP0004215_abnormal_myocardial_fiber1.02951970
40MP0000566_synostosis0.96670742
41MP0003252_abnormal_bile_duct0.93658540
42MP0003950_abnormal_plasma_membrane0.93360925
43MP0002095_abnormal_skin_pigmentation0.93000615
44MP0003943_abnormal_hepatobiliary_system0.86082067
45MP0005248_abnormal_Harderian_gland0.84359763
46MP0001191_abnormal_skin_condition0.84002370
47MP0005365_abnormal_bile_salt0.79348781
48MP0002282_abnormal_trachea_morphology0.77964300
49MP0005330_cardiomyopathy0.75054769
50MP0001340_abnormal_eyelid_morphology0.73747117
51MP0000534_abnormal_ureter_morphology0.73688811
52MP0000751_myopathy0.73490632
53MP0002972_abnormal_cardiac_muscle0.72597497
54MP0001661_extended_life_span0.72327852
55MP0004484_altered_response_of0.66579813
56MP0008438_abnormal_cutaneous_collagen0.60752236
57MP0004084_abnormal_cardiac_muscle0.60647763
58MP0006138_congestive_heart_failure0.58474950
59MP0003315_abnormal_perineum_morphology0.57713389
60MP0001879_abnormal_lymphatic_vessel0.55869939
61MP0000462_abnormal_digestive_system0.55850432
62MP0002249_abnormal_larynx_morphology0.55738487
63MP0003191_abnormal_cellular_cholesterol0.55397327
64MP0001784_abnormal_fluid_regulation0.54171429
65MP0005451_abnormal_body_composition0.53317459
66MP0004885_abnormal_endolymph0.52805322
67MP0000749_muscle_degeneration0.51697222
68MP0004272_abnormal_basement_membrane0.50936547
69MP0003385_abnormal_body_wall0.47813675
70MP0001346_abnormal_lacrimal_gland0.46849636
71MP0003942_abnormal_urinary_system0.46465189
72MP0003937_abnormal_limbs/digits/tail_de0.45363188
73MP0004185_abnormal_adipocyte_glucose0.44891943
74MP0000538_abnormal_urinary_bladder0.42725417
75MP0004264_abnormal_extraembryonic_tissu0.40283655
76MP0002111_abnormal_tail_morphology0.38366630
77MP0003123_paternal_imprinting0.37488335
78MP0000627_abnormal_mammary_gland0.36339035
79MP0009278_abnormal_bone_marrow0.35538394
80MP0001851_eye_inflammation0.35510203
81MP0003755_abnormal_palate_morphology0.35152459
82MP0010630_abnormal_cardiac_muscle0.34934954
83MP0009840_abnormal_foam_cell0.34613977
84MP0001544_abnormal_cardiovascular_syste0.34285506
85MP0005385_cardiovascular_system_phenoty0.34285506
86MP0000613_abnormal_salivary_gland0.33878250
87MP0002697_abnormal_eye_size0.33274902
88MP0003137_abnormal_impulse_conducting0.31640837
89MP0005023_abnormal_wound_healing0.31531215
90MP0005620_abnormal_muscle_contractility0.31295130
91MP0001286_abnormal_eye_development0.29991112
92MP0002177_abnormal_outer_ear0.29802042
93MP0002233_abnormal_nose_morphology0.29798948
94MP0004087_abnormal_muscle_fiber0.28791521
95MP0005165_increased_susceptibility_to0.28179146
96MP0004036_abnormal_muscle_relaxation0.27559904
97MP0003011_delayed_dark_adaptation0.26822751
98MP0000432_abnormal_head_morphology0.25949056
99MP0002970_abnormal_white_adipose0.25469181
100MP0006292_abnormal_olfactory_placode0.25459491

Predicted human phenotypes

RankGene SetZ-score
1Woolly hair (HP:0002224)9.67344652
2Pili torti (HP:0003777)9.31519836
3Slow-growing hair (HP:0002217)8.65967227
4Abnormality of hair growth rate (HP:0011363)8.65967227
5Brittle hair (HP:0002299)7.50496579
6Abnormality of nail color (HP:0100643)6.15622585
7Abnormal pancreas size (HP:0012094)5.93961243
8Nail dystrophy (HP:0008404)5.70152943
9Abnormal hair laboratory examination (HP:0003328)5.49229023
10Fragile nails (HP:0001808)5.07056211
11Follicular hyperkeratosis (HP:0007502)5.02681491
12Onycholysis (HP:0001806)4.76327386
13Alopecia of scalp (HP:0002293)4.44871599
14Palmoplantar hyperkeratosis (HP:0000972)4.43533694
15Right ventricular cardiomyopathy (HP:0011663)4.40134979
16Thick nail (HP:0001805)4.26359770
17Plantar hyperkeratosis (HP:0007556)4.20121422
18Palmar hyperkeratosis (HP:0010765)4.15361409
19Fine hair (HP:0002213)4.04474558
20Conjunctival hamartoma (HP:0100780)4.00069328
21Increased IgE level (HP:0003212)3.80928812
22Unilateral renal agenesis (HP:0000122)3.45173074
23Erythema (HP:0010783)3.26932049
24Milia (HP:0001056)3.25891676
25Sparse eyelashes (HP:0000653)3.25058750
26Ventricular tachycardia (HP:0004756)3.09406642
27Oral leukoplakia (HP:0002745)3.08539964
28Congenital, generalized hypertrichosis (HP:0004540)3.07708048
29Hamartoma of the eye (HP:0010568)2.81702602
30Hypoplasia of the uterus (HP:0000013)2.79590984
31Ventricular fibrillation (HP:0001663)2.79516774
32Gout (HP:0001997)2.79109706
33Ridged nail (HP:0001807)2.78605990
34Bicornuate uterus (HP:0000813)2.69422833
35Curly hair (HP:0002212)2.60388735
36Palmoplantar keratoderma (HP:0000982)2.48507306
37Erythroderma (HP:0001019)2.47491135
38Shawl scrotum (HP:0000049)2.45134601
39Parakeratosis (HP:0001036)2.39057023
40Aplasia cutis congenita (HP:0001057)2.38327661
41Abnormal blistering of the skin (HP:0008066)2.37914487
42Chorioretinal atrophy (HP:0000533)2.35731351
43Abnormality of the frontal sinuses (HP:0002687)2.29408480
44Sudden death (HP:0001699)2.28791596
45Exocrine pancreatic insufficiency (HP:0001738)2.24885288
46Annular pancreas (HP:0001734)2.22585575
47Aplasia/hypoplasia of the uterus (HP:0008684)2.17243484
48Neck muscle weakness (HP:0000467)2.15371985
49Hyporeflexia of lower limbs (HP:0002600)2.14703479
50Advanced eruption of teeth (HP:0006288)2.13894318
51Congenital ichthyosiform erythroderma (HP:0007431)2.13648044
52Torticollis (HP:0000473)2.02277555
53Hypotrichosis (HP:0001006)11.2426844
54Amelogenesis imperfecta (HP:0000705)1.99358691
55Acute necrotizing encephalopathy (HP:0006965)1.98887146
56Natal tooth (HP:0000695)1.98869071
57Absent eyelashes (HP:0000561)1.97395054
58Rectal prolapse (HP:0002035)1.97322912
59Vertebral arch anomaly (HP:0008438)1.97152584
60Pruritus (HP:0000989)1.92014232
61Late onset (HP:0003584)1.89694642
62Preauricular pit (HP:0004467)1.88495085
63Periauricular skin pits (HP:0100277)1.88495085
64Intention tremor (HP:0002080)1.86956357
65Progressive macrocephaly (HP:0004481)1.86410226
66Abnormal mitochondria in muscle tissue (HP:0008316)1.86272816
67Renal dysplasia (HP:0000110)1.80175403
68Skin pits (HP:0100276)1.80082217
69Hypohidrosis (HP:0000966)1.73864913
70Acute encephalopathy (HP:0006846)1.72525583
71Corneal erosion (HP:0200020)1.67697024
72Prolonged neonatal jaundice (HP:0006579)1.66617987
73Ureteral stenosis (HP:0000071)1.66423661
74Dry hair (HP:0011359)1.63802864
75Adenoma sebaceum (HP:0009720)1.62724019
76Angiofibromas (HP:0010615)1.62724019
77Syncope (HP:0001279)1.62443704
78Distal lower limb muscle weakness (HP:0009053)1.58226177
79Concave nail (HP:0001598)1.57867762
80Craniofacial dystonia (HP:0012179)1.57858369
81Difficulty walking (HP:0002355)1.54159000
82Blepharitis (HP:0000498)1.51887945
83Ureteral obstruction (HP:0006000)1.47149070
84Recurrent corneal erosions (HP:0000495)1.45924864
85Hamartoma (HP:0010566)1.45816441
86Ventricular arrhythmia (HP:0004308)1.41865133
87Abnormal biliary tract morphology (HP:0012440)1.40928451
88Autoamputation (HP:0001218)1.40600165
89Focal dystonia (HP:0004373)1.40567538
90Bundle branch block (HP:0011710)1.40557429
91Renal hypoplasia (HP:0000089)1.39464996
92Atrophic scars (HP:0001075)1.39373301
93Abnormality of the parietal bone (HP:0002696)1.38752461
94Neonatal death (HP:0003811)1.38475448
95Anonychia (HP:0001798)1.36661090
96Pheochromocytoma (HP:0002666)1.36210183
97Exercise-induced muscle cramps (HP:0003710)1.34588602
98Melanocytic nevus (HP:0000995)1.32914808
99Muscle fiber splitting (HP:0003555)1.32892773
100Widely patent fontanelles and sutures (HP:0004492)1.32751393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK23.99306171
2MAP3K33.92161855
3MAP2K63.04228588
4EPHA23.03038937
5TTN2.74256239
6CLK12.65005042
7MAP2K32.54709581
8FER2.41753075
9EPHB22.30434919
10ERN12.21653464
11MET2.13478499
12STK38L2.11258885
13FGFR12.08055207
14BCR2.08047303
15MST1R2.01902968
16MST41.96080770
17MAPKAPK31.93105298
18MAP3K71.82555362
19MAP3K131.74457942
20RIPK11.69382051
21TRPM71.67301198
22MAP3K61.51834158
23TRIB31.50743900
24PKN21.50348079
25FRK1.48724179
26STK381.48319205
27NME11.47750587
28PIK3CA1.44597344
29PTK2B1.40802904
30EPHB11.36313009
31FGFR31.31526250
32TAOK11.31073129
33LMTK21.28426267
34FGFR21.18485893
35PTK61.15454833
36PDK41.14683021
37PDK31.14683021
38LATS11.13713535
39MAP3K51.12971645
40BMX1.07333528
41MYLK1.05045728
42MAP3K101.04238063
43PTK21.02348909
44MAP3K111.02083542
45STK390.95616462
46PDGFRA0.94449756
47MAP3K20.93994750
48MAP3K80.89187568
49PBK0.88896490
50PIK3CG0.88196456
51EIF2AK30.84548118
52SIK10.78647772
53RPS6KB20.78240673
54SGK30.76714707
55SCYL20.76323730
56SGK20.75030470
57PRKG20.70447221
58MAPKAPK20.70212251
59PRKCH0.69955129
60ERBB40.68486623
61PAK30.66678558
62PRKD10.65844112
63MAP3K90.64293736
64PASK0.62213739
65TGFBR10.58681442
66ROCK20.58137898
67SIK30.58045601
68CDC42BPA0.57735160
69FGFR40.56875509
70MAPK120.56739174
71SGK2230.56447676
72SGK4940.56447676
73ERBB30.56170544
74WNK40.51855863
75LRRK20.51405508
76RPS6KA40.51218146
77LATS20.50286987
78NME20.50269367
79RPS6KA10.48283803
80ERBB20.47350366
81PDK20.47245014
82TYK20.43511123
83TIE10.42883120
84PRKD30.42085324
85TESK10.41842047
86PRKAA20.41497892
87CSNK1E0.40847366
88TTK0.40626252
89NEK10.39543962
90ROCK10.39271602
91PAK40.38688999
92CAMK2D0.37476586
93CSNK1G20.35804230
94MAP3K10.34808238
95AKT30.34449808
96EPHA40.33642688
97GSK3A0.31281863
98DAPK30.31064015
99CDK60.30497133
100DYRK1B0.30284643

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.16535235
2Parkinsons disease_Homo sapiens_hsa050123.68000767
3Alzheimers disease_Homo sapiens_hsa050103.31842684
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.27526489
5Linoleic acid metabolism_Homo sapiens_hsa005913.26076417
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.69806263
7Cardiac muscle contraction_Homo sapiens_hsa042602.64066811
8Huntingtons disease_Homo sapiens_hsa050162.36653682
9Fat digestion and absorption_Homo sapiens_hsa049752.27426756
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27029149
11Fatty acid elongation_Homo sapiens_hsa000622.22205158
12Sulfur metabolism_Homo sapiens_hsa009202.02631302
13Nitrogen metabolism_Homo sapiens_hsa009101.95592292
14Basal cell carcinoma_Homo sapiens_hsa052171.94985798
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77542194
16Phenylalanine metabolism_Homo sapiens_hsa003601.68171298
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58089789
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55728763
19Ether lipid metabolism_Homo sapiens_hsa005651.38920503
20Butanoate metabolism_Homo sapiens_hsa006501.38757043
21Ribosome_Homo sapiens_hsa030101.32874064
22VEGF signaling pathway_Homo sapiens_hsa043701.26675950
23Non-small cell lung cancer_Homo sapiens_hsa052231.23765271
24Arachidonic acid metabolism_Homo sapiens_hsa005901.23746796
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23537348
26Melanogenesis_Homo sapiens_hsa049161.16162875
27Propanoate metabolism_Homo sapiens_hsa006401.16012613
28Dilated cardiomyopathy_Homo sapiens_hsa054141.16006758
29Thyroid cancer_Homo sapiens_hsa052161.15717992
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13746404
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12894308
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.11733898
33Axon guidance_Homo sapiens_hsa043601.10556344
34Proteoglycans in cancer_Homo sapiens_hsa052051.05369583
35Hippo signaling pathway_Homo sapiens_hsa043901.04861381
36GnRH signaling pathway_Homo sapiens_hsa049121.03209930
37Fatty acid degradation_Homo sapiens_hsa000711.02189413
38Bladder cancer_Homo sapiens_hsa052191.02116664
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01989366
40beta-Alanine metabolism_Homo sapiens_hsa004100.93726382
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93474764
42Mineral absorption_Homo sapiens_hsa049780.91435510
43Dorso-ventral axis formation_Homo sapiens_hsa043200.88605169
44Glioma_Homo sapiens_hsa052140.87308850
45Tyrosine metabolism_Homo sapiens_hsa003500.85893608
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84417360
47Tight junction_Homo sapiens_hsa045300.84255316
48Arginine biosynthesis_Homo sapiens_hsa002200.83697892
49ECM-receptor interaction_Homo sapiens_hsa045120.83671588
50PPAR signaling pathway_Homo sapiens_hsa033200.81732304
51Hedgehog signaling pathway_Homo sapiens_hsa043400.81016554
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78810722
53Carbon metabolism_Homo sapiens_hsa012000.77308894
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76075197
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75997127
56Endometrial cancer_Homo sapiens_hsa052130.75652683
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.74142927
58Notch signaling pathway_Homo sapiens_hsa043300.72882399
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71832097
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.71422428
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.70931748
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69685927
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68335120
64Wnt signaling pathway_Homo sapiens_hsa043100.65975729
65Fatty acid metabolism_Homo sapiens_hsa012120.65045637
66Small cell lung cancer_Homo sapiens_hsa052220.64962554
67Chronic myeloid leukemia_Homo sapiens_hsa052200.64524551
68Pancreatic secretion_Homo sapiens_hsa049720.62282016
69Rap1 signaling pathway_Homo sapiens_hsa040150.61775038
70Estrogen signaling pathway_Homo sapiens_hsa049150.60369093
71Histidine metabolism_Homo sapiens_hsa003400.56975373
72Peroxisome_Homo sapiens_hsa041460.55247914
73Acute myeloid leukemia_Homo sapiens_hsa052210.52650858
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49755831
75Ras signaling pathway_Homo sapiens_hsa040140.48815013
76Insulin resistance_Homo sapiens_hsa049310.46765367
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43940891
78Arginine and proline metabolism_Homo sapiens_hsa003300.43631347
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.43380086
80Focal adhesion_Homo sapiens_hsa045100.41317964
81Toxoplasmosis_Homo sapiens_hsa051450.40212197
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39391906
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.38968966
84Salivary secretion_Homo sapiens_hsa049700.37920206
85Amoebiasis_Homo sapiens_hsa051460.37225870
86Hepatitis C_Homo sapiens_hsa051600.36681490
87Pathways in cancer_Homo sapiens_hsa052000.33512859
88Viral myocarditis_Homo sapiens_hsa054160.32290587
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31338668
90Renal cell carcinoma_Homo sapiens_hsa052110.31147106
91Melanoma_Homo sapiens_hsa052180.30795148
92Long-term potentiation_Homo sapiens_hsa047200.30124941
93Prolactin signaling pathway_Homo sapiens_hsa049170.29803207
94Gastric acid secretion_Homo sapiens_hsa049710.27755231
95Platelet activation_Homo sapiens_hsa046110.27207370
96MAPK signaling pathway_Homo sapiens_hsa040100.25880964
97MicroRNAs in cancer_Homo sapiens_hsa052060.25439893
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25173777
99TNF signaling pathway_Homo sapiens_hsa046680.25155626
100Caffeine metabolism_Homo sapiens_hsa002320.25105479

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