KRT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule metabolic process (GO:0044036)9.58591037
2cell wall macromolecule catabolic process (GO:0016998)9.58591037
3peptide cross-linking (GO:0018149)8.43274592
4epidermis development (GO:0008544)7.00343628
5response to phenylpropanoid (GO:0080184)6.91959212
6apical protein localization (GO:0045176)6.80037899
7hair follicle morphogenesis (GO:0031069)6.54655117
8regulation of toll-like receptor 4 signaling pathway (GO:0034143)6.54056717
9establishment of tissue polarity (GO:0007164)6.30208375
10establishment of planar polarity (GO:0001736)6.30208375
11response to vitamin A (GO:0033189)6.17718710
12citrulline biosynthetic process (GO:0019240)6.10084054
13regulation of keratinocyte differentiation (GO:0045616)6.00595305
14sarcoplasmic reticulum calcium ion transport (GO:0070296)5.97668068
15surfactant homeostasis (GO:0043129)5.86809675
16regulation of skeletal muscle contraction (GO:0014819)5.82516903
17eyelid development in camera-type eye (GO:0061029)5.69315344
18planar cell polarity pathway involved in neural tube closure (GO:0090179)5.57532143
19ectoderm development (GO:0007398)5.53898246
20regulation of ruffle assembly (GO:1900027)5.53272402
21keratinocyte proliferation (GO:0043616)5.50403727
22keratinocyte differentiation (GO:0030216)5.44352680
23gap junction assembly (GO:0016264)5.40078710
24asymmetric protein localization (GO:0008105)5.23989563
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.22050016
26coronary vasculature morphogenesis (GO:0060977)4.90290669
27lymph vessel development (GO:0001945)4.89169372
28hair cell differentiation (GO:0035315)4.88779689
29localization within membrane (GO:0051668)4.84511593
30membrane raft organization (GO:0031579)4.78092337
31chemical homeostasis within a tissue (GO:0048875)4.68925348
32regulation of secondary heart field cardioblast proliferation (GO:0003266)4.61761590
33regulation of cardioblast proliferation (GO:0003264)4.61761590
34regulation of relaxation of muscle (GO:1901077)4.60579555
35innate immune response in mucosa (GO:0002227)4.48181594
36skeletal muscle contraction (GO:0003009)4.41449285
37muscle organ morphogenesis (GO:0048644)4.28600809
38O-glycan processing (GO:0016266)4.28338678
39positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.25999017
40* epithelial cell differentiation (GO:0030855)4.10308774
41actin-myosin filament sliding (GO:0033275)4.08442103
42muscle filament sliding (GO:0030049)4.08442103
43keratinocyte development (GO:0003334)4.06411212
44citrulline metabolic process (GO:0000052)4.05439581
45purine nucleotide salvage (GO:0032261)3.95992669
46positive regulation of endothelial cell differentiation (GO:0045603)3.95773558
47linoleic acid metabolic process (GO:0043651)3.95388190
48negative regulation of bone mineralization (GO:0030502)3.88263862
49hemidesmosome assembly (GO:0031581)3.86023543
50cellular response to retinoic acid (GO:0071300)3.83698510
51positive regulation of vesicle fusion (GO:0031340)3.78981783
52long-chain fatty acid biosynthetic process (GO:0042759)3.78345088
53hypotonic response (GO:0006971)3.77885800
54sequestering of metal ion (GO:0051238)3.76671863
55regulation of skeletal muscle cell differentiation (GO:2001014)3.76391458
56epidermal cell differentiation (GO:0009913)3.75902680
57leukocyte aggregation (GO:0070486)3.71250072
58negative regulation of cell-cell adhesion (GO:0022408)3.71041982
59bundle of His cell to Purkinje myocyte communication (GO:0086069)3.70843002
60epithelial cell-cell adhesion (GO:0090136)3.66463245
61gas transport (GO:0015669)3.61203905
62regulation of epidermal cell differentiation (GO:0045604)3.59448151
63regulation of endothelial cell differentiation (GO:0045601)3.58690829
64retinoic acid metabolic process (GO:0042573)3.58677782
65chronic inflammatory response (GO:0002544)3.58660344
66negative regulation of biomineral tissue development (GO:0070168)3.57394769
67mucosal immune response (GO:0002385)3.57215598
68cellular response to epidermal growth factor stimulus (GO:0071364)3.54558289
69negative regulation of cell-substrate adhesion (GO:0010812)3.53599421
70positive regulation of epidermal cell differentiation (GO:0045606)3.52980753
71one-carbon compound transport (GO:0019755)3.49674326
72negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.46152327
73negative regulation of calcium ion transmembrane transport (GO:1903170)3.46152327
74ethanol oxidation (GO:0006069)3.44474043
75actin-mediated cell contraction (GO:0070252)3.44327019
76peptidyl-arginine modification (GO:0018195)3.42527325
77negative regulation of toll-like receptor signaling pathway (GO:0034122)3.41786460
78positive regulation of epidermis development (GO:0045684)3.40671849
79desmosome organization (GO:0002934)3.39931132
80molting cycle process (GO:0022404)3.37986141
81hair cycle process (GO:0022405)3.37986141
82Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.37211543
83organ or tissue specific immune response (GO:0002251)3.35961250
84epithelium development (GO:0060429)3.29912668
85embryonic viscerocranium morphogenesis (GO:0048703)3.29504276
86lipoxygenase pathway (GO:0019372)3.27483380
87multicellular organismal water homeostasis (GO:0050891)3.27412127
88cellular response to glucocorticoid stimulus (GO:0071385)3.25252261
89regulation of establishment of planar polarity (GO:0090175)3.25192882
90outer ear morphogenesis (GO:0042473)3.22397022
91tooth mineralization (GO:0034505)3.22103702
92endothelial tube morphogenesis (GO:0061154)3.21266359
93morphogenesis of an endothelium (GO:0003159)3.21266359
94detection of bacterium (GO:0016045)3.20763598
95leukocyte migration involved in inflammatory response (GO:0002523)3.18955739
96establishment of skin barrier (GO:0061436)3.17662447
97positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.15774034
98regulation of axon regeneration (GO:0048679)3.14725700
99regulation of neuron projection regeneration (GO:0070570)3.14725700
100cellular response to corticosteroid stimulus (GO:0071384)3.12665448
101ethanol metabolic process (GO:0006067)3.12273602
102regulation of pH (GO:0006885)3.10332878
103regulation of water loss via skin (GO:0033561)3.09394409
104retinol metabolic process (GO:0042572)3.08761360
105cellular response to nitric oxide (GO:0071732)3.04244000
106actin filament-based movement (GO:0030048)3.00804847
107mucosal-associated lymphoid tissue development (GO:0048537)3.00094814
108Peyers patch development (GO:0048541)3.00094814
109negative regulation of acute inflammatory response (GO:0002674)2.99813955
110blood vessel maturation (GO:0001955)2.99178988
111cochlea morphogenesis (GO:0090103)2.98804207
112regulation of vasculogenesis (GO:2001212)2.97499565
113negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.95982729
114renal absorption (GO:0070293)2.95747768
115intestinal epithelial cell development (GO:0060576)2.94576664
116embryonic camera-type eye development (GO:0031076)2.93760960
117positive regulation of Cdc42 GTPase activity (GO:0043089)2.93307770
118plasma membrane repair (GO:0001778)2.92763567
119response to epidermal growth factor (GO:0070849)2.90225759
120wound healing (GO:0042060)2.89483958
121artery development (GO:0060840)2.88822625
122negative regulation of keratinocyte proliferation (GO:0010839)2.88724360
123skeletal muscle adaptation (GO:0043501)2.86534438
124negative regulation of thymocyte apoptotic process (GO:0070244)2.86223990
125protein localization to endosome (GO:0036010)2.85289320
126myotube differentiation (GO:0014902)2.84478230
127phenylpropanoid metabolic process (GO:0009698)2.84394388
128positive regulation of monocyte chemotaxis (GO:0090026)2.84016799
129detection of other organism (GO:0098543)2.83403506
130polyol transport (GO:0015791)2.81238424
131histamine secretion (GO:0001821)2.79043777
132response to vitamin E (GO:0033197)2.78093657
133lymphangiogenesis (GO:0001946)2.76813445
134regulation of germinal center formation (GO:0002634)2.76530166
135non-canonical Wnt signaling pathway (GO:0035567)2.76517071
136vascular endothelial growth factor signaling pathway (GO:0038084)2.72778032
137extracellular negative regulation of signal transduction (GO:1900116)2.71207139
138extracellular regulation of signal transduction (GO:1900115)2.71207139
139water homeostasis (GO:0030104)2.71044117
140muscle cell fate commitment (GO:0042693)2.70152877
141negative regulation of interferon-gamma production (GO:0032689)2.69735397
142endosome organization (GO:0007032)2.68436962
143protein O-linked glycosylation (GO:0006493)2.67985812
144positive regulation of protein depolymerization (GO:1901881)2.66431466
145regulation of penile erection (GO:0060405)2.65793755
146response to nitric oxide (GO:0071731)2.65041710
147blood vessel remodeling (GO:0001974)2.64302030
148creatine metabolic process (GO:0006600)2.63305310
149primary alcohol metabolic process (GO:0034308)2.62530726
150primary alcohol catabolic process (GO:0034310)2.61494554
1514-hydroxyproline metabolic process (GO:0019471)2.60404602
152exogenous drug catabolic process (GO:0042738)2.60138961
153monovalent inorganic cation homeostasis (GO:0055067)2.58073669
154fucosylation (GO:0036065)2.57448903
155positive regulation of myotube differentiation (GO:0010831)2.56006651
156hormone catabolic process (GO:0042447)2.55496623
157regulation of epidermis development (GO:0045682)2.54645270
158regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.54278718
159negative regulation of peptidase activity (GO:0010466)2.53236408
160phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.52584950
161negative regulation of response to cytokine stimulus (GO:0060761)2.50284455
162L-fucose catabolic process (GO:0042355)2.49182791
163fucose catabolic process (GO:0019317)2.49182791
164L-fucose metabolic process (GO:0042354)2.49182791
165toxin metabolic process (GO:0009404)2.48958976
166positive regulation of keratinocyte differentiation (GO:0045618)2.48472586
167response to UV-B (GO:0010224)2.47207241
168ventricular cardiac muscle cell action potential (GO:0086005)2.47136634
169molting cycle (GO:0042303)2.46623428
170epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45493190
171negative regulation of response to reactive oxygen species (GO:1901032)2.44776393
172response to retinoic acid (GO:0032526)2.44447964
173lung alveolus development (GO:0048286)2.44077319
174striated muscle contraction (GO:0006941)2.43635340
175cytoskeletal anchoring at plasma membrane (GO:0007016)2.43002597
176lung lobe morphogenesis (GO:0060463)2.42672147
177sarcomere organization (GO:0045214)2.39901260
178keratinization (GO:0031424)16.3147653
179transepithelial transport (GO:0070633)12.0457514
180negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)10.8940487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.57542560
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human5.28259595
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.07875139
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.75933794
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.58459914
6VDR_22108803_ChIP-Seq_LS180_Human3.35128308
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.33688931
8GATA1_22025678_ChIP-Seq_K562_Human3.18124129
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.03919789
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.62392865
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44114210
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.32386515
13CLOCK_20551151_ChIP-Seq_293T_Human2.21496128
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07437424
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94754787
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91187795
17TP63_22573176_ChIP-Seq_HFKS_Human1.84279332
18ATF3_27146783_Chip-Seq_COLON_Human1.77565442
19ZNF263_19887448_ChIP-Seq_K562_Human1.77005896
20SOX2_20726797_ChIP-Seq_SW620_Human1.75297994
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.72438919
22CJUN_26792858_Chip-Seq_BT549_Human1.65065379
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.64803153
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.64803153
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62846195
26FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.62804691
27UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.60816229
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57129360
29PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.51328572
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50566664
31RACK7_27058665_Chip-Seq_MCF-7_Human1.46318979
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44701216
33P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40565451
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35976609
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.34316174
36CTCF_27219007_Chip-Seq_Bcells_Human1.33093948
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32905745
38TBX20_22328084_ChIP-Seq_HEART_Mouse1.31626729
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.31626729
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30081910
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.29680316
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26705105
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.25902780
44GATA3_24758297_ChIP-Seq_MCF-7_Human1.25030512
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23974860
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23974860
47AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23462416
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.23429419
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22827087
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21790928
51CEBPB_22108803_ChIP-Seq_LS180_Human1.19876191
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17285681
53AHR_22903824_ChIP-Seq_MCF-7_Human1.17117463
54E2F1_20622854_ChIP-Seq_HELA_Human1.16054952
55SA1_27219007_Chip-Seq_Bcells_Human1.16016702
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.15729450
57P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.14903319
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13654846
59* RXR_22158963_ChIP-Seq_LIVER_Mouse1.12920759
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12097834
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.11946748
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10981119
63ERG_20517297_ChIP-Seq_VCAP_Human1.10863026
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09384763
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07593314
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.05946980
67GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.04632146
68GATA6_25053715_ChIP-Seq_YYC3_Human1.03999066
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.03659356
70GATA6_21074721_ChIP-Seq_CACO-2_Human1.03446651
71RXR_22108803_ChIP-Seq_LS180_Human1.03226617
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00945753
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00837159
74GATA1_19941826_ChIP-Seq_K562_Human1.00291614
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00054378
76CREB1_26743006_Chip-Seq_LNCaP_Human0.99670332
77FOXH1_21741376_ChIP-Seq_ESCs_Human0.98518508
78* CTCF_20526341_ChIP-Seq_ESCs_Human0.97740005
79TP63_23658742_ChIP-Seq_EP156T_Human0.97715669
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97692992
81KLF5_25053715_ChIP-Seq_YYC3_Human0.97138600
82YY1_22570637_ChIP-Seq_MALME-3M_Human0.96443513
83ELK3_25401928_ChIP-Seq_HUVEC_Human0.96032189
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95917433
85SOX3_22085726_ChIP-Seq_NPCs_Mouse0.94892727
86EGR1_19032775_ChIP-ChIP_M12_Human0.94307604
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94183745
88* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94092607
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92774963
90BCAT_22108803_ChIP-Seq_LS180_Human0.92065314
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91995526
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91446464
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90532655
94ERG_21242973_ChIP-ChIP_JURKAT_Human0.90521929
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90510466
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90469467
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90210268
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.89770755
99TP53_16413492_ChIP-PET_HCT116_Human0.89642996
100HTT_18923047_ChIP-ChIP_STHdh_Human0.89524162
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89477784
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88922988
103TCF4_18268006_ChIP-ChIP_LS174T_Human0.88577229
104IRF8_21731497_ChIP-ChIP_J774_Mouse0.87994265
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86862539
106GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.86523214
107SPI1_20517297_ChIP-Seq_HL60_Human0.86441765
108FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85909417
109GATA2_19941826_ChIP-Seq_K562_Human0.85834009
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85782123
111OCT1_27270436_Chip-Seq_PROSTATE_Human0.85326066
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84660380
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83804508
114RBPJ_21746931_ChIP-Seq_IB4_Human0.82978663
115GATA4_25053715_ChIP-Seq_YYC3_Human0.82897880
116PHF8_20622854_ChIP-Seq_HELA_Human0.82885622
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81790161
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81717814
119SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80965254
120TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80269483
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79871713
122SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.79771584
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79754467
124MTF2_20144788_ChIP-Seq_MESCs_Mouse0.79465790
125SMC4_20622854_ChIP-Seq_HELA_Human0.78555917
126LXR_22292898_ChIP-Seq_THP-1_Human0.77916585
127ZNF274_21170338_ChIP-Seq_K562_Hela0.77897768
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77347788
129KDM2B_26808549_Chip-Seq_K562_Human0.77325392
130* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76740703
131MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.76681024
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.76666968
133BCOR_27268052_Chip-Seq_Bcells_Human0.76171491
134STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76004345
135KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75891537
136* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.75791570
137BCL6_27268052_Chip-Seq_Bcells_Human0.74867482
138E2F1_17053090_ChIP-ChIP_MCF-7_Human0.74730833
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.72262449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation8.41443329
2MP0002234_abnormal_pharynx_morphology4.51599565
3MP0002796_impaired_skin_barrier4.45584071
4MP0005275_abnormal_skin_tensile4.37911083
5MP0010234_abnormal_vibrissa_follicle4.03553272
6MP0001958_emphysema3.52687506
7MP0000751_myopathy3.37351000
8MP0002138_abnormal_hepatobiliary_system3.16002042
9MP0004782_abnormal_surfactant_physiolog3.13023563
10MP0001879_abnormal_lymphatic_vessel2.67167028
11MP0000749_muscle_degeneration2.53952716
12MP0003646_muscle_fatigue2.52442068
13MP0005501_abnormal_skin_physiology2.43267951
14MP0003878_abnormal_ear_physiology2.37080866
15MP0005377_hearing/vestibular/ear_phenot2.37080866
16MP0003705_abnormal_hypodermis_morpholog2.33150465
17MP0004885_abnormal_endolymph2.31474817
18MP0005167_abnormal_blood-brain_barrier2.09224874
19MP0003566_abnormal_cell_adhesion2.03418876
20MP0004264_abnormal_extraembryonic_tissu2.01357657
21MP0004130_abnormal_muscle_cell1.98723611
22MP0002837_dystrophic_cardiac_calcinosis1.98473854
23MP0004185_abnormal_adipocyte_glucose1.88377446
24MP0010368_abnormal_lymphatic_system1.86243081
25MP0009053_abnormal_anal_canal1.84072745
26MP0000747_muscle_weakness1.83353223
27MP0004272_abnormal_basement_membrane1.76796805
28MP0000566_synostosis1.76230670
29MP0000465_gastrointestinal_hemorrhage1.75464620
30MP0003252_abnormal_bile_duct1.72443702
31MP0004036_abnormal_muscle_relaxation1.69518521
32MP0009697_abnormal_copulation1.68527386
33MP0003950_abnormal_plasma_membrane1.67409965
34MP0002106_abnormal_muscle_physiology1.66259915
35MP0000759_abnormal_skeletal_muscle1.65808546
36MP0002332_abnormal_exercise_endurance1.62492141
37MP0003806_abnormal_nucleotide_metabolis1.62269490
38MP0000678_abnormal_parathyroid_gland1.61135056
39MP0004087_abnormal_muscle_fiber1.60844572
40MP0003191_abnormal_cellular_cholesterol1.57611848
41MP0004145_abnormal_muscle_electrophysio1.56181105
42MP0000537_abnormal_urethra_morphology1.54496840
43MP0000733_abnormal_muscle_development1.54269532
44MP0010030_abnormal_orbit_morphology1.48744729
45MP0000377_abnormal_hair_follicle1.44485870
46MP0010678_abnormal_skin_adnexa1.39469920
47MP0004084_abnormal_cardiac_muscle1.37148795
48MP0002139_abnormal_hepatobiliary_system1.36330722
49MP0001765_abnormal_ion_homeostasis1.32924772
50MP0005620_abnormal_muscle_contractility1.31505102
51MP0000343_altered_response_to1.30140676
52MP0005369_muscle_phenotype1.29674195
53* MP0000762_abnormal_tongue_morphology1.29470831
54MP0001177_atelectasis1.27898597
55MP0003453_abnormal_keratinocyte_physiol1.27839815
56MP0001216_abnormal_epidermal_layer1.27644012
57MP0000750_abnormal_muscle_regeneration1.26649406
58MP0005388_respiratory_system_phenotype1.25423354
59MP0002133_abnormal_respiratory_system1.25423354
60MP0002909_abnormal_adrenal_gland1.25278971
61MP0002972_abnormal_cardiac_muscle1.17890936
62MP0008875_abnormal_xenobiotic_pharmacok1.17299415
63MP0005503_abnormal_tendon_morphology1.16711513
64MP0010771_integument_phenotype1.15354208
65MP0006054_spinal_hemorrhage1.11932006
66MP0006138_congestive_heart_failure1.09351019
67MP0008995_early_reproductive_senescence1.09193287
68MP0005385_cardiovascular_system_phenoty1.07013586
69MP0001544_abnormal_cardiovascular_syste1.07013586
70MP0004947_skin_inflammation1.01936225
71MP0009780_abnormal_chondrocyte_physiolo1.01791975
72MP0008438_abnormal_cutaneous_collagen1.01298595
73MP0002269_muscular_atrophy1.00047133
74MP0005330_cardiomyopathy0.99317736
75MP0010352_gastrointestinal_tract_polyps0.98953017
76MP0005666_abnormal_adipose_tissue0.98873938
77MP0002254_reproductive_system_inflammat0.95834245
78MP0005266_abnormal_metabolism0.95050028
79MP0005083_abnormal_biliary_tract0.92569972
80MP0000647_abnormal_sebaceous_gland0.91959125
81MP0000579_abnormal_nail_morphology0.91475252
82MP0004484_altered_response_of0.88614216
83MP0002295_abnormal_pulmonary_circulatio0.87795216
84MP0002098_abnormal_vibrissa_morphology0.87052225
85MP0000383_abnormal_hair_follicle0.86402107
86MP0003221_abnormal_cardiomyocyte_apopto0.86117536
87MP0002249_abnormal_larynx_morphology0.85608729
88MP0010630_abnormal_cardiac_muscle0.84660885
89MP0002060_abnormal_skin_morphology0.84419961
90MP0001191_abnormal_skin_condition0.82623224
91MP0005248_abnormal_Harderian_gland0.81169850
92MP0003075_altered_response_to0.79935968
93MP0005636_abnormal_mineral_homeostasis0.78146777
94MP0002127_abnormal_cardiovascular_syste0.77189800
95MP0003828_pulmonary_edema0.75891660
96MP0008789_abnormal_olfactory_epithelium0.74008636
97MP0000427_abnormal_hair_cycle0.73781512
98MP0003091_abnormal_cell_migration0.73577062
99MP0000249_abnormal_blood_vessel0.72650926
100MP0003329_amyloid_beta_deposits0.71830919
101MP0003724_increased_susceptibility_to0.71692178
102MP0005165_increased_susceptibility_to0.71475611
103MP0003300_gastrointestinal_ulcer0.71405985
104MP0000613_abnormal_salivary_gland0.69027621
105MP0005023_abnormal_wound_healing0.68876753
106MP0001851_eye_inflammation0.68120034
107MP0003045_fibrosis0.68104066
108MP0003567_abnormal_fetal_cardiomyocyte0.67711616
109MP0000049_abnormal_middle_ear0.67336302
110MP0005166_decreased_susceptibility_to0.66510583
111MP0005409_darkened_coat_color0.65950331
112MP0009931_abnormal_skin_appearance0.65697361
113MP0000767_abnormal_smooth_muscle0.64920004
114* MP0000467_abnormal_esophagus_morphology0.64386747
115MP0004019_abnormal_vitamin_homeostasis0.63362016
116MP0005595_abnormal_vascular_smooth0.62882815
117MP0003941_abnormal_skin_development0.62877948
118MP0003011_delayed_dark_adaptation0.62404956
119* MP0000367_abnormal_coat/_hair0.62315195
120MP0003315_abnormal_perineum_morphology0.56915250
121MP0003638_abnormal_response/metabolism_0.56630553
122MP0001784_abnormal_fluid_regulation0.52372835
123MP0002111_abnormal_tail_morphology0.52253185
124MP0009643_abnormal_urine_homeostasis0.51901084
125MP0005499_abnormal_olfactory_system0.49670291
126MP0005394_taste/olfaction_phenotype0.49670291
127MP0001485_abnormal_pinna_reflex0.48645593
128MP0005375_adipose_tissue_phenotype0.47166405
129MP0001340_abnormal_eyelid_morphology0.46250812
130MP0001270_distended_abdomen0.45390060
131MP0003937_abnormal_limbs/digits/tail_de0.43787450
132MP0000462_abnormal_digestive_system0.40679682
133MP0002136_abnormal_kidney_physiology0.39893374
134MP0003755_abnormal_palate_morphology0.37036998
135MP0002108_abnormal_muscle_morphology0.33812172
136MP0000681_abnormal_thyroid_gland0.33205017
137MP0002233_abnormal_nose_morphology0.32009971
138MP0000477_abnormal_intestine_morphology0.30678573
139MP0005451_abnormal_body_composition0.28052448
140* MP0000470_abnormal_stomach_morphology0.26636079
141MP0002009_preneoplasia0.25214419
142* MP0002095_abnormal_skin_pigmentation0.24878524
143MP0004197_abnormal_fetal_growth/weight/0.24416684
144MP0005670_abnormal_white_adipose0.22640162
145MP0008569_lethality_at_weaning0.21413906
146MP0005164_abnormal_response_to0.19037385
147MP0005508_abnormal_skeleton_morphology0.16279565
148MP0000627_abnormal_mammary_gland0.15754648
149MP0004381_abnormal_hair_follicle0.15328725
150MP0000858_altered_metastatic_potential0.14879595
151MP0002089_abnormal_postnatal_growth/wei0.14382142
152MP0002282_abnormal_trachea_morphology0.13380843
153MP0002653_abnormal_ependyma_morphology0.12978423

Predicted human phenotypes

RankGene SetZ-score
1Erythroderma (HP:0001019)9.46227907
2Abnormality of nail color (HP:0100643)7.84299356
3Palmoplantar hyperkeratosis (HP:0000972)7.83310889
4Palmar hyperkeratosis (HP:0010765)7.42149281
5Lip pit (HP:0100267)6.73575487
6Distal arthrogryposis (HP:0005684)6.35874628
7Plantar hyperkeratosis (HP:0007556)6.32935937
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.54856284
9Muscle fiber inclusion bodies (HP:0100299)5.52749539
10Alopecia of scalp (HP:0002293)5.46454642
11Hypotrichosis (HP:0001006)5.40198139
12Exercise-induced myalgia (HP:0003738)5.36541879
13* Oral leukoplakia (HP:0002745)5.13789374
14Round ear (HP:0100830)5.11530837
15Nemaline bodies (HP:0003798)5.06728403
16Abnormality of the salivary glands (HP:0010286)4.76941678
17Erythema (HP:0010783)4.68245849
18Type 1 muscle fiber predominance (HP:0003803)4.63935592
19Right ventricular cardiomyopathy (HP:0011663)4.59415203
20Pustule (HP:0200039)4.58998980
21Increased connective tissue (HP:0009025)4.49309687
22Exercise-induced muscle cramps (HP:0003710)4.49096853
23Absent eyelashes (HP:0000561)4.47560095
24Ulnar deviation of the wrist (HP:0003049)4.42450150
25Nail dystrophy (HP:0008404)4.35366338
26Difficulty running (HP:0009046)4.28552772
27Abnormality of secondary sexual hair (HP:0009888)4.16828596
28Abnormality of the axillary hair (HP:0100134)4.16828596
29Muscle hypertrophy of the lower extremities (HP:0008968)4.08852006
30Nasal polyposis (HP:0100582)4.08243823
31Hyporeflexia of lower limbs (HP:0002600)4.06288008
32Calf muscle hypertrophy (HP:0008981)4.02730904
33Absent phalangeal crease (HP:0006109)3.95956812
34Myopathic facies (HP:0002058)3.93354860
35Interstitial pulmonary disease (HP:0006530)3.87631979
36Brittle hair (HP:0002299)3.83980404
37Absent hair (HP:0002298)3.83811198
38Muscle fiber splitting (HP:0003555)3.81255451
39Increased IgE level (HP:0003212)3.78354391
40Myoglobinuria (HP:0002913)3.74023575
41Calcaneovalgus deformity (HP:0001848)3.70208424
42Villous atrophy (HP:0011473)3.68345189
43Abnormality of small intestinal villus morphology (HP:0011472)3.68345189
44Autoimmune thrombocytopenia (HP:0001973)3.66461672
45Mesangial abnormality (HP:0001966)3.63459994
46Popliteal pterygium (HP:0009756)3.63035727
47Sparse scalp hair (HP:0002209)3.59046641
48Hypohidrosis (HP:0000966)3.53953489
49Unilateral renal agenesis (HP:0000122)3.50673029
50Rimmed vacuoles (HP:0003805)3.50252134
51Acanthosis nigricans (HP:0000956)3.47445607
52Increased variability in muscle fiber diameter (HP:0003557)3.39071322
53Autoimmune hemolytic anemia (HP:0001890)3.34039577
54Sparse eyelashes (HP:0000653)3.30492403
55Abnormal finger flexion creases (HP:0006143)3.28103373
56Abnormality of skeletal muscle fiber size (HP:0012084)3.27096371
57Chronic bronchitis (HP:0004469)3.24736410
58Deformed tarsal bones (HP:0008119)3.24293812
59Hematochezia (HP:0002573)3.22705271
60Onycholysis (HP:0001806)3.22356158
61Polycythemia (HP:0001901)3.22143145
62Abnormality of placental membranes (HP:0011409)3.22130972
63Amniotic constriction ring (HP:0009775)3.22130972
64Dehydration (HP:0001944)3.21493788
65Congenital malformation of the right heart (HP:0011723)3.16872568
66Double outlet right ventricle (HP:0001719)3.16872568
67Gangrene (HP:0100758)3.10238224
68Distal lower limb muscle weakness (HP:0009053)3.03890724
69Urticaria (HP:0001025)3.01264992
70Hyperkalemia (HP:0002153)2.93486120
71Congenital ichthyosiform erythroderma (HP:0007431)2.91023533
72Furrowed tongue (HP:0000221)2.84737147
73Abnormality of the parathyroid morphology (HP:0011766)2.82020844
74Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.81566427
75Frequent falls (HP:0002359)2.81049548
76EMG: myopathic abnormalities (HP:0003458)2.75489945
77Abnormality of the calf musculature (HP:0001430)2.74030135
78Autoamputation (HP:0001218)2.69664872
79Thick nail (HP:0001805)2.64030616
80Trismus (HP:0000211)2.63554179
81Cholelithiasis (HP:0001081)2.62991165
82Cupped ribs (HP:0000887)2.62742313
83Hypoplastic labia majora (HP:0000059)2.61627354
84Myotonia (HP:0002486)2.58932730
85Muscle stiffness (HP:0003552)2.57702710
86Difficulty climbing stairs (HP:0003551)2.53745753
87Recurrent corneal erosions (HP:0000495)2.51725169
88Paralysis (HP:0003470)2.49409606
89Abnormality of the distal phalanges of the toes (HP:0010182)2.48959555
90Abnormality of the calcaneus (HP:0008364)2.47725805
91Neck muscle weakness (HP:0000467)2.46939250
92Cystic hygroma (HP:0000476)2.46179310
93Blepharitis (HP:0000498)2.42453692
94Abnormality of the nasal mucosa (HP:0000433)2.41657880
95Abnormality of the labia majora (HP:0012881)2.41243816
96Areflexia of lower limbs (HP:0002522)2.39876944
97Lack of skin elasticity (HP:0100679)2.39752297
98Abnormality of the aortic arch (HP:0012303)2.39674964
99Distal lower limb amyotrophy (HP:0008944)2.39259001
100Facial diplegia (HP:0001349)2.38224117
101Woolly hair (HP:0002224)2.37459710
102Abnormal gallbladder morphology (HP:0012437)2.37308885
103Multifactorial inheritance (HP:0001426)2.37261942
104Long clavicles (HP:0000890)2.34815550
105Hyperthyroidism (HP:0000836)2.34314268
106Spontaneous hematomas (HP:0007420)2.33184495
107Hypoplastic left heart (HP:0004383)2.32371312
108Rhabdomyolysis (HP:0003201)2.26716997
109Parakeratosis (HP:0001036)2.24405003
110Decreased circulating renin level (HP:0003351)2.24221815
111Elbow flexion contracture (HP:0002987)2.23314274
112Scapular winging (HP:0003691)2.21511709
113Tetany (HP:0001281)2.20342999
114Corneal erosion (HP:0200020)2.18651046
115Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.14329386
116Oligodontia (HP:0000677)2.13630819
117Hyperactive renin-angiotensin system (HP:0000841)2.12729310
118Abnormality of B cell number (HP:0010975)2.12637537
119B lymphocytopenia (HP:0010976)2.12637537
120Cerebral hemorrhage (HP:0001342)2.12047698
121Pili torti (HP:0003777)2.09476163
122Visceral angiomatosis (HP:0100761)2.09063767
123Gout (HP:0001997)2.08276340
124Malnutrition (HP:0004395)2.08066261
125Fine hair (HP:0002213)2.05525213
126Cerebral aneurysm (HP:0004944)2.04081036
127Renal salt wasting (HP:0000127)2.03910126
128Exotropia (HP:0000577)2.01693820
129Hypoplastic toenails (HP:0001800)2.01252722
130Mildly elevated creatine phosphokinase (HP:0008180)1.97875942
131Seborrheic dermatitis (HP:0001051)1.97716577
132Neoplasm of the heart (HP:0100544)1.97286222
133Abnormality of chloride homeostasis (HP:0011422)1.94642544
134Abnormal blistering of the skin (HP:0008066)1.94318062
135Milia (HP:0001056)1.94051503
136Pruritus (HP:0000989)1.92076974
137Deep venous thrombosis (HP:0002625)1.92058008
138Tubulointerstitial fibrosis (HP:0005576)1.91717038
139Hypoplastic ischia (HP:0003175)1.91596492
140Coarse hair (HP:0002208)1.90437992
141Abnormal hair laboratory examination (HP:0003328)1.89364568
142Hemangiomatosis (HP:0007461)1.87250001
143Ulnar bowing (HP:0003031)1.85463534
144Esophageal varix (HP:0002040)1.84932098
145Fragile nails (HP:0001808)1.84860602
146Wrist flexion contracture (HP:0001239)1.84445025
147Skin pits (HP:0100276)1.83772434
148Melanocytic nevus (HP:0000995)1.82852976
149Lower limb amyotrophy (HP:0007210)1.82661798
150Ectropion (HP:0000656)1.82345966
151Palmoplantar keratoderma (HP:0000982)1.81013929
152Foot dorsiflexor weakness (HP:0009027)1.80631660
153Vascular calcification (HP:0004934)1.80103617
154Bronchomalacia (HP:0002780)1.78111908
155Muscular dystrophy (HP:0003560)1.76853926
156Dry skin (HP:0000958)1.76368651
157Keratoconjunctivitis sicca (HP:0001097)1.75222359
158Hyperaldosteronism (HP:0000859)1.74715152
159Atrophic scars (HP:0001075)1.74185624
160Abnormality of the ischium (HP:0003174)1.74154216
161Labial hypoplasia (HP:0000066)1.74025709
162Tarsal synostosis (HP:0008368)1.73399277
163Achilles tendon contracture (HP:0001771)1.72668423
164Cardiovascular calcification (HP:0011915)1.72456763
165Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71771791
166Spinal rigidity (HP:0003306)1.71639768
167Thickened nuchal skin fold (HP:0000474)1.68895287
168Hypergammaglobulinemia (HP:0010702)1.67779414
169Hoarse voice (HP:0001609)1.67181702
170Curly hair (HP:0002212)1.66135462
171Ulnar claw (HP:0001178)1.63635501
172Sepsis (HP:0100806)1.63101026
173Abnormality of renin-angiotensin system (HP:0000847)1.60392416
174Hypoplastic female external genitalia (HP:0012815)1.59578407
175Synostosis of carpal bones (HP:0005048)1.58871635
176Slow-growing hair (HP:0002217)1.58807745
177Abnormality of hair growth rate (HP:0011363)1.58807745
178Delusions (HP:0000746)1.55609149
179Knee flexion contracture (HP:0006380)1.55363261
180Keratoconjunctivitis (HP:0001096)1.55267510
181Abnormality of the dental root (HP:0006486)1.54689883
182Taurodontia (HP:0000679)1.54689883
183Abnormality of permanent molar morphology (HP:0011071)1.54689883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN8.51184638
2TIE14.76308194
3MAP3K63.30549101
4PIK3CG3.25663444
5TRIB32.89748173
6EPHA22.79239385
7OBSCN2.62629173
8GRK62.33547881
9PHKG12.15183215
10PHKG22.15183215
11FER2.12643219
12LRRK22.11727800
13MAP2K32.01491673
14STK241.87613991
15RIPK11.80152944
16TGFBR21.76915404
17PBK1.74078839
18PDK41.70765668
19PDK31.70765668
20PKN21.66210329
21MAP3K31.63742602
22DMPK1.54813202
23TRPM71.48597788
24FGFR21.45461454
25MST41.39792631
26PTK61.39641909
27NEK11.36406123
28PINK11.34296516
29PDK21.32013220
30MST1R1.31294307
31MAP3K21.30219202
32MAPKAPK31.27728326
33ERBB31.25452850
34EPHB11.20472922
35MARK21.20302862
36PAK41.15845412
37EPHB21.09602909
38MAP3K121.07295422
39PDGFRA1.06936532
40MAP3K91.03083590
41CDK120.94006702
42DDR20.91657017
43WNK10.90104237
44KSR20.89272309
45SIK10.87279839
46PRKD10.86225506
47MAP3K70.83854581
48STK100.83298652
49LATS10.83079912
50SMG10.82435765
51MAPK150.80811889
52STK390.77899646
53BCKDK0.74436534
54FRK0.74365454
55MET0.74141215
56MAP3K130.71908307
57DAPK20.70166200
58FGFR40.70144798
59MYLK0.69965247
60MAPKAPK20.67930054
61PIK3CA0.66878604
62MAP2K40.66609355
63PRKD20.66044979
64BLK0.64664550
65PRKCH0.64160003
66LMTK20.63718642
67IRAK10.63528990
68LIMK10.62130740
69ILK0.61379065
70WNK40.59852490
71KDR0.59619339
72CSK0.58496499
73PDPK10.58376311
74RPS6KB20.56753677
75BCR0.55484482
76FGFR30.55469278
77PDGFRB0.53335740
78MAPK120.52466404
79BMX0.50042287
80PRKCI0.49944931
81TESK10.49523381
82GRK10.48110171
83PTK20.46777526
84CDC42BPA0.46566268
85ROCK20.45958092
86TAOK10.45804599
87RET0.44742270
88MAP2K10.44224174
89NME10.44133303
90ERN10.43473085
91PAK30.42249135
92ICK0.41616122
93EPHA30.41482021
94EGFR0.41452909
95FGR0.40849791
96PRKAA20.40544523
97IRAK30.40130028
98EEF2K0.38594986
99PDK10.38587198
100IRAK20.38243574
101SCYL20.37724852
102NTRK10.37503687
103FGFR10.37475473
104MAP2K60.37334337
105MAP3K10.37298895
106MAPK110.35962176
107JAK30.35260259
108MATK0.33727463
109CAMK2A0.33632211
110TYK20.32540841
111FYN0.32277038
112JAK10.31841946
113ZAP700.31786658
114OXSR10.31612080
115MAPK70.31511845
116GSK3A0.30938579
117MAP2K20.30069865
118CDK60.28146815
119TYRO30.27836134
120NEK90.27417941
121SRC0.27368425
122PRKCD0.27333035
123ROCK10.27244477
124MAP3K110.26806913
125ERBB20.25628393
126NEK60.25171852
127ADRBK10.24401793
128ARAF0.24325699
129CDK70.24164080
130CAMK2G0.24045574
131SGK30.23254521
132TBK10.22011395
133LATS20.21933200
134HCK0.21669358
135JAK20.21272227
136TGFBR10.21002042
137IRAK40.20418998
138ABL20.19962010
139NME20.18750379
140MTOR0.16340573
141PAK20.15565314
142AURKB0.14907064
143STK30.13171474

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.06783527
2Salivary secretion_Homo sapiens_hsa049703.77267266
3Phenylalanine metabolism_Homo sapiens_hsa003603.75065796
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.15054086
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.09422258
6Fat digestion and absorption_Homo sapiens_hsa049752.70558437
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.60875160
8Histidine metabolism_Homo sapiens_hsa003402.53419060
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36553899
10Chemical carcinogenesis_Homo sapiens_hsa052042.23301501
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.20997792
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.19773220
13Tyrosine metabolism_Homo sapiens_hsa003502.18554710
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.00550411
15beta-Alanine metabolism_Homo sapiens_hsa004101.98870100
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.94398131
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90404859
18Glycerolipid metabolism_Homo sapiens_hsa005611.84588405
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81002042
20Fatty acid degradation_Homo sapiens_hsa000711.79288123
21ECM-receptor interaction_Homo sapiens_hsa045121.44989989
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41784469
23Tight junction_Homo sapiens_hsa045301.39321752
24Dilated cardiomyopathy_Homo sapiens_hsa054141.38461654
25Caffeine metabolism_Homo sapiens_hsa002321.35840113
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35433366
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34566269
28Nitrogen metabolism_Homo sapiens_hsa009101.33775870
29Renin secretion_Homo sapiens_hsa049241.30969939
30Circadian rhythm_Homo sapiens_hsa047101.27861440
31Sphingolipid metabolism_Homo sapiens_hsa006001.27469488
32Arginine biosynthesis_Homo sapiens_hsa002201.21353095
33Adherens junction_Homo sapiens_hsa045201.19087278
34Focal adhesion_Homo sapiens_hsa045101.18990515
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17661810
36Propanoate metabolism_Homo sapiens_hsa006401.14281973
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10682021
38Carbon metabolism_Homo sapiens_hsa012001.09558816
39Acute myeloid leukemia_Homo sapiens_hsa052211.08281359
40Fatty acid metabolism_Homo sapiens_hsa012121.08143350
41Gastric acid secretion_Homo sapiens_hsa049711.04409479
42Notch signaling pathway_Homo sapiens_hsa043301.03831642
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.01949983
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.00403715
45Endocytosis_Homo sapiens_hsa041440.99864266
46Fatty acid biosynthesis_Homo sapiens_hsa000610.95038705
47Pentose phosphate pathway_Homo sapiens_hsa000300.93554357
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.93068031
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88429217
50Glucagon signaling pathway_Homo sapiens_hsa049220.86833309
51Pertussis_Homo sapiens_hsa051330.86287339
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.84996479
53Bladder cancer_Homo sapiens_hsa052190.84088495
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83820871
55VEGF signaling pathway_Homo sapiens_hsa043700.82990479
56Amoebiasis_Homo sapiens_hsa051460.82807778
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82435578
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82074816
59Olfactory transduction_Homo sapiens_hsa047400.81789335
60GnRH signaling pathway_Homo sapiens_hsa049120.81353630
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78146530
62Glutathione metabolism_Homo sapiens_hsa004800.77149730
63Fructose and mannose metabolism_Homo sapiens_hsa000510.77001822
64Proteoglycans in cancer_Homo sapiens_hsa052050.76139566
65Platelet activation_Homo sapiens_hsa046110.73899949
66Oxytocin signaling pathway_Homo sapiens_hsa049210.73403101
67Tryptophan metabolism_Homo sapiens_hsa003800.72000899
68Insulin signaling pathway_Homo sapiens_hsa049100.71925474
69Cardiac muscle contraction_Homo sapiens_hsa042600.71558566
70Pyruvate metabolism_Homo sapiens_hsa006200.70956990
71Phototransduction_Homo sapiens_hsa047440.69384709
72Pancreatic secretion_Homo sapiens_hsa049720.69018687
73Insulin resistance_Homo sapiens_hsa049310.67278816
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66879867
75Linoleic acid metabolism_Homo sapiens_hsa005910.66426800
76Starch and sucrose metabolism_Homo sapiens_hsa005000.66256749
77Biosynthesis of amino acids_Homo sapiens_hsa012300.65935512
78Glioma_Homo sapiens_hsa052140.65354119
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.64410441
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63821624
81Rap1 signaling pathway_Homo sapiens_hsa040150.63549142
82PPAR signaling pathway_Homo sapiens_hsa033200.62415767
83Sulfur metabolism_Homo sapiens_hsa009200.62353669
84Bile secretion_Homo sapiens_hsa049760.61364043
85Melanogenesis_Homo sapiens_hsa049160.60545483
86Alzheimers disease_Homo sapiens_hsa050100.60534986
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.60471910
88Hepatitis C_Homo sapiens_hsa051600.60116991
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59653166
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59264375
91Renal cell carcinoma_Homo sapiens_hsa052110.59039449
92Pancreatic cancer_Homo sapiens_hsa052120.58549873
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58178807
94Long-term potentiation_Homo sapiens_hsa047200.57634773
95Ether lipid metabolism_Homo sapiens_hsa005650.54811504
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54412425
97p53 signaling pathway_Homo sapiens_hsa041150.53352058
98Inositol phosphate metabolism_Homo sapiens_hsa005620.53153431
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52995666
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52449480
101Shigellosis_Homo sapiens_hsa051310.51259736
102Circadian entrainment_Homo sapiens_hsa047130.51149544
103Thyroid cancer_Homo sapiens_hsa052160.51005850
104Complement and coagulation cascades_Homo sapiens_hsa046100.50091722
105Sulfur relay system_Homo sapiens_hsa041220.49933341
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48941338
107Ras signaling pathway_Homo sapiens_hsa040140.48845789
108Choline metabolism in cancer_Homo sapiens_hsa052310.48432866
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48151232
110Estrogen signaling pathway_Homo sapiens_hsa049150.47468430
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47330285
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45656841
113Small cell lung cancer_Homo sapiens_hsa052220.44765910
114Arginine and proline metabolism_Homo sapiens_hsa003300.44723363
115Calcium signaling pathway_Homo sapiens_hsa040200.44370294
116Retinol metabolism_Homo sapiens_hsa008300.43985915
117Hippo signaling pathway_Homo sapiens_hsa043900.43714911
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43072673
119Viral myocarditis_Homo sapiens_hsa054160.42550040
120Axon guidance_Homo sapiens_hsa043600.41248958
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40533902
122AMPK signaling pathway_Homo sapiens_hsa041520.38147157
123ErbB signaling pathway_Homo sapiens_hsa040120.37281989
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.36636301
125Mineral absorption_Homo sapiens_hsa049780.36304235
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36180516
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35930959
128Phagosome_Homo sapiens_hsa041450.35865476
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.35767883
130Arachidonic acid metabolism_Homo sapiens_hsa005900.35360334
131HIF-1 signaling pathway_Homo sapiens_hsa040660.34854247
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.34169355
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33466219
134Fatty acid elongation_Homo sapiens_hsa000620.33286429
135Butanoate metabolism_Homo sapiens_hsa006500.31656001
136Selenocompound metabolism_Homo sapiens_hsa004500.31205859
137Long-term depression_Homo sapiens_hsa047300.30179983
138Chronic myeloid leukemia_Homo sapiens_hsa052200.30145950
139Toxoplasmosis_Homo sapiens_hsa051450.30138511
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29183914
141Salmonella infection_Homo sapiens_hsa051320.28153997
142MicroRNAs in cancer_Homo sapiens_hsa052060.27458487
143Endometrial cancer_Homo sapiens_hsa052130.26159135
144Influenza A_Homo sapiens_hsa051640.25796748
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25412968
146Galactose metabolism_Homo sapiens_hsa000520.23834010
147Malaria_Homo sapiens_hsa051440.22542310
148TNF signaling pathway_Homo sapiens_hsa046680.22339020
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21556665

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