ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.68624448
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.26021461
3	epithelial cilium movement (GO:0003351)	4.56288750
4	cilium or flagellum-dependent cell motility (GO:0001539)	4.37929342
5	axonemal dynein complex assembly (GO:0070286)	4.28018156
6	cilium movement (GO:0003341)	4.20993812
7	kynurenine metabolic process (GO:0070189)	4.05766527
8	protein polyglutamylation (GO:0018095)	4.05315553
9	axoneme assembly (GO:0035082)	4.01750790
10	tryptophan catabolic process (GO:0006569)	3.95484703
11	indole-containing compound catabolic process (GO:0042436)	3.95484703
12	indolalkylamine catabolic process (GO:0046218)	3.95484703
13	response to pheromone (GO:0019236)	3.86923628
14	L-fucose catabolic process (GO:0042355)	3.84233978
15	fucose catabolic process (GO:0019317)	3.84233978
16	L-fucose metabolic process (GO:0042354)	3.84233978
17	cellular ketone body metabolic process (GO:0046950)	3.77138379
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.75043787
19	negative regulation of telomere maintenance (GO:0032205)	3.70973681
20	indolalkylamine metabolic process (GO:0006586)	3.69662507
21	kidney morphogenesis (GO:0060993)	3.63272171
22	regulation of cilium movement (GO:0003352)	3.58088329
23	gamma-aminobutyric acid transport (GO:0015812)	3.52377906
24	DNA deamination (GO:0045006)	3.51613810
25	somite development (GO:0061053)	3.49106349
26	platelet dense granule organization (GO:0060155)	3.39156102
27	ketone body metabolic process (GO:1902224)	3.38482939
28	tryptophan metabolic process (GO:0006568)	3.35727032
29	pyrimidine nucleobase catabolic process (GO:0006208)	3.29078111
30	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.18248441
31	regulation of mesoderm development (GO:2000380)	3.16888373
32	piRNA metabolic process (GO:0034587)	3.11655297
33	neurotransmitter metabolic process (GO:0042133)	3.11399960
34	synaptic transmission, cholinergic (GO:0007271)	3.09973732
35	rRNA catabolic process (GO:0016075)	3.09786722
36	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.09594143
37	nephron tubule morphogenesis (GO:0072078)	2.96998387
38	nephron epithelium morphogenesis (GO:0072088)	2.96998387
39	regulation of microtubule-based movement (GO:0060632)	2.96265583
40	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.93811029
41	protein localization to cilium (GO:0061512)	2.93737149
42	cellular biogenic amine catabolic process (GO:0042402)	2.93515660
43	amine catabolic process (GO:0009310)	2.93515660
44	parturition (GO:0007567)	2.93446518
45	cornea development in camera-type eye (GO:0061303)	2.91768917
46	indole-containing compound metabolic process (GO:0042430)	2.89024252
47	sperm motility (GO:0030317)	2.88932216
48	nucleobase catabolic process (GO:0046113)	2.88344577
49	nonmotile primary cilium assembly (GO:0035058)	2.86990730
50	respiratory chain complex IV assembly (GO:0008535)	2.86876657
51	retinal cone cell development (GO:0046549)	2.86382748
52	cilium organization (GO:0044782)	2.86148678
53	protein complex biogenesis (GO:0070271)	2.85718889
54	exogenous drug catabolic process (GO:0042738)	2.85508553
55	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.85322993
56	ATP synthesis coupled proton transport (GO:0015986)	2.85322993
57	organic cation transport (GO:0015695)	2.83285275
58	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.81969194
59	neuronal action potential (GO:0019228)	2.81906313
60	detection of light stimulus involved in sensory perception (GO:0050962)	2.81328521
61	detection of light stimulus involved in visual perception (GO:0050908)	2.81328521
62	regulation of hexokinase activity (GO:1903299)	2.80537986
63	regulation of glucokinase activity (GO:0033131)	2.80537986
64	cilium morphogenesis (GO:0060271)	2.79862496
65	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.79246406
66	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.79246406
67	NADH dehydrogenase complex assembly (GO:0010257)	2.79246406
68	glycerophospholipid catabolic process (GO:0046475)	2.77145442
69	cilium assembly (GO:0042384)	2.74233590
70	auditory receptor cell stereocilium organization (GO:0060088)	2.72783643
71	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.72280692
72	regulation of action potential (GO:0098900)	2.71302934
73	cytochrome complex assembly (GO:0017004)	2.66255980
74	mitochondrial respiratory chain complex assembly (GO:0033108)	2.65779140
75	photoreceptor cell maintenance (GO:0045494)	2.65467384
76	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.63513285
77	cAMP catabolic process (GO:0006198)	2.62638138
78	negative regulation of mast cell activation (GO:0033004)	2.62311929
79	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.61352396
80	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.60725457
81	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.60379429
82	preassembly of GPI anchor in ER membrane (GO:0016254)	2.60329757
83	photoreceptor cell development (GO:0042461)	2.59821442
84	transmission of nerve impulse (GO:0019226)	2.59681559
85	neurotransmitter biosynthetic process (GO:0042136)	2.59471774
86	behavioral response to ethanol (GO:0048149)	2.59402629
87	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.58153462
88	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.58112517
89	sulfation (GO:0051923)	2.57250095
90	regulation of neurotransmitter uptake (GO:0051580)	2.54328022
91	primary amino compound metabolic process (GO:1901160)	2.53289193
92	dopamine transport (GO:0015872)	2.52560957
93	motile cilium assembly (GO:0044458)	2.52070100
94	multicellular organism reproduction (GO:0032504)	2.49602251
95	cell proliferation in forebrain (GO:0021846)	2.49509627
96	drug catabolic process (GO:0042737)	2.49080433
97	negative regulation of T cell differentiation in thymus (GO:0033085)	2.48614069
98	rhodopsin mediated signaling pathway (GO:0016056)	2.48069531
99	DNA methylation involved in gamete generation (GO:0043046)	2.47346159
100	positive regulation of mitochondrial fission (GO:0090141)	2.46626132

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.15191510
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.94439335
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.22084559
4	VDR_22108803_ChIP-Seq_LS180_Human	3.04737602
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.69390428
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40520918
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30129697
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.29968079
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10211456
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04341978
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.95525661
12	IGF1R_20145208_ChIP-Seq_DFB_Human	1.94294318
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.92810110
14	FUS_26573619_Chip-Seq_HEK293_Human	1.90232113
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.90107932
16	IRF1_19129219_ChIP-ChIP_H3396_Human	1.88678637
17	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.87577425
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.84508581
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.79974929
20	P300_19829295_ChIP-Seq_ESCs_Human	1.78084693
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.78044031
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.73451645
23	EWS_26573619_Chip-Seq_HEK293_Human	1.71490558
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.70054060
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.65432422
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.61143208
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.56735428
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.52200005
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.50187889
30	AR_25329375_ChIP-Seq_VCAP_Human	1.47500713
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.46801994
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.46801994
33	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.46738580
34	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.46315371
35	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.44260975
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43649281
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43341242
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.41775063
39	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.39904042
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39131049
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39131049
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37948791
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37668918
44	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.37135094
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36986191
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34936386
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.34094034
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.32472731
49	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.30821730
50	STAT3_23295773_ChIP-Seq_U87_Human	1.30260513
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28758708
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.28758708
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28460473
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28224760
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27440981
56	TCF4_23295773_ChIP-Seq_U87_Human	1.26552133
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26291619
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26291619
59	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26004836
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24962868
61	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.24652581
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.24420663
63	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.24314822
64	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.23988683
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23398066
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23264072
67	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.22259824
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.20844100
69	MYC_18940864_ChIP-ChIP_HL60_Human	1.19854818
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19095838
71	AR_21572438_ChIP-Seq_LNCaP_Human	1.18310451
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17738017
73	NCOR_22424771_ChIP-Seq_293T_Human	1.16331588
74	DROSHA_22980978_ChIP-Seq_HELA_Human	1.15510555
75	ERA_21632823_ChIP-Seq_H3396_Human	1.14739030
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13988974
77	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.13566277
78	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.13391149
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13287949
80	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.12903873
81	MYC_19829295_ChIP-Seq_ESCs_Human	1.12547491
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.12088212
83	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11289167
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11219366
85	AR_20517297_ChIP-Seq_VCAP_Human	1.09241418
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07835704
87	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.05542183
88	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.04780768
89	TAF2_19829295_ChIP-Seq_ESCs_Human	1.04029377
90	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.04024069
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02991140
92	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.02017929
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01749016
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01515380
95	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.01057368
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00928129
97	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.00328642
98	JUN_21703547_ChIP-Seq_K562_Human	0.99847042
99	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.99774110
100	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.99132792

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.00704996
2	MP0003646_muscle_fatigue	2.70398206
3	MP0002102_abnormal_ear_morphology	2.69453014
4	MP0002653_abnormal_ependyma_morphology	2.60657346
5	MP0002837_dystrophic_cardiac_calcinosis	2.49738094
6	MP0005551_abnormal_eye_electrophysiolog	2.35942309
7	MP0003136_yellow_coat_color	2.33698640
8	MP0005646_abnormal_pituitary_gland	2.26921762
9	MP0003195_calcinosis	2.23959994
10	MP0001986_abnormal_taste_sensitivity	2.18722113
11	MP0001968_abnormal_touch/_nociception	2.14746933
12	MP0004885_abnormal_endolymph	2.12917009
13	MP0002876_abnormal_thyroid_physiology	2.12695185
14	MP0009745_abnormal_behavioral_response	2.02401965
15	MP0008875_abnormal_xenobiotic_pharmacok	2.01464136
16	MP0006292_abnormal_olfactory_placode	1.92577120
17	MP0004142_abnormal_muscle_tone	1.90055035
18	MP0002272_abnormal_nervous_system	1.85491522
19	MP0005645_abnormal_hypothalamus_physiol	1.84892300
20	MP0003011_delayed_dark_adaptation	1.83562105
21	MP0006072_abnormal_retinal_apoptosis	1.79014208
22	MP0003122_maternal_imprinting	1.73773862
23	MP0003787_abnormal_imprinting	1.73177135
24	MP0004145_abnormal_muscle_electrophysio	1.70110178
25	MP0008872_abnormal_physiological_respon	1.67626077
26	MP0009046_muscle_twitch	1.67024009
27	MP0002736_abnormal_nociception_after	1.65691256
28	MP0004133_heterotaxia	1.65624079
29	MP0001486_abnormal_startle_reflex	1.64252310
30	MP0005423_abnormal_somatic_nervous	1.63545887
31	MP0004742_abnormal_vestibular_system	1.62770408
32	MP0006276_abnormal_autonomic_nervous	1.59946031
33	MP0004043_abnormal_pH_regulation	1.58871105
34	MP0002733_abnormal_thermal_nociception	1.55640725
35	MP0001485_abnormal_pinna_reflex	1.55047865
36	MP0003880_abnormal_central_pattern	1.53515979
37	MP0005253_abnormal_eye_physiology	1.53377059
38	MP0003283_abnormal_digestive_organ	1.53091489
39	MP0002572_abnormal_emotion/affect_behav	1.53042361
40	MP0000631_abnormal_neuroendocrine_gland	1.48745894
41	MP0001529_abnormal_vocalization	1.45468205
42	MP0002735_abnormal_chemical_nociception	1.44658894
43	MP0002557_abnormal_social/conspecific_i	1.43336149
44	MP0002160_abnormal_reproductive_system	1.43031439
45	MP0000372_irregular_coat_pigmentation	1.42987570
46	MP0001984_abnormal_olfaction	1.42718347
47	MP0005389_reproductive_system_phenotype	1.39398501
48	MP0001501_abnormal_sleep_pattern	1.39058409
49	MP0005084_abnormal_gallbladder_morpholo	1.37882832
50	MP0004130_abnormal_muscle_cell	1.37537262
51	MP0002928_abnormal_bile_duct	1.37494702
52	MP0001970_abnormal_pain_threshold	1.36495856
53	MP0000569_abnormal_digit_pigmentation	1.35223500
54	MP0001919_abnormal_reproductive_system	1.34358038
55	MP0002064_seizures	1.31640505
56	MP0002063_abnormal_learning/memory/cond	1.31477698
57	MP0003119_abnormal_digestive_system	1.30509330
58	MP0005410_abnormal_fertilization	1.29852614
59	MP0003635_abnormal_synaptic_transmissio	1.29711572
60	MP0000026_abnormal_inner_ear	1.24492355
61	MP0002938_white_spotting	1.22419460
62	MP0002734_abnormal_mechanical_nocicepti	1.21060997
63	MP0000049_abnormal_middle_ear	1.20653321
64	MP0001905_abnormal_dopamine_level	1.18422870
65	MP0004147_increased_porphyrin_level	1.13315827
66	MP0000778_abnormal_nervous_system	1.13089440
67	MP0002638_abnormal_pupillary_reflex	1.12231073
68	MP0000427_abnormal_hair_cycle	1.11993159
69	MP0003121_genomic_imprinting	1.11626417
70	MP0002138_abnormal_hepatobiliary_system	1.10378749
71	MP0001502_abnormal_circadian_rhythm	1.09106574
72	MP0002234_abnormal_pharynx_morphology	1.08484386
73	MP0002067_abnormal_sensory_capabilities	1.08399056
74	MP0005195_abnormal_posterior_eye	1.06553496
75	MP0001963_abnormal_hearing_physiology	1.05493023
76	MP0002752_abnormal_somatic_nervous	1.04356004
77	MP0008789_abnormal_olfactory_epithelium	1.03876909
78	MP0002184_abnormal_innervation	0.98946520
79	MP0005187_abnormal_penis_morphology	0.98696185
80	MP0005174_abnormal_tail_pigmentation	0.98470700
81	MP0008775_abnormal_heart_ventricle	0.96719589
82	MP0003698_abnormal_male_reproductive	0.96621314
83	MP0003878_abnormal_ear_physiology	0.93154468
84	MP0005377_hearing/vestibular/ear_phenot	0.93154468
85	MP0004924_abnormal_behavior	0.93061835
86	MP0005386_behavior/neurological_phenoty	0.93061835
87	MP0001440_abnormal_grooming_behavior	0.92991332
88	MP0009379_abnormal_foot_pigmentation	0.92238962
89	MP0003938_abnormal_ear_development	0.91297000
90	MP0002277_abnormal_respiratory_mucosa	0.89453750
91	MP0000230_abnormal_systemic_arterial	0.87711149
92	MP0002909_abnormal_adrenal_gland	0.85103123
93	MP0004215_abnormal_myocardial_fiber	0.84357121
94	MP0004859_abnormal_synaptic_plasticity	0.84038878
95	MP0000955_abnormal_spinal_cord	0.82095109
96	MP0002229_neurodegeneration	0.81656048
97	MP0005167_abnormal_blood-brain_barrier	0.81637677
98	MP0003137_abnormal_impulse_conducting	0.80242712
99	MP0002751_abnormal_autonomic_nervous	0.80082742
100	MP0008995_early_reproductive_senescence	0.79812306

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.40701562
2	Pancreatic fibrosis (HP:0100732)	4.28096758
3	Abnormality of midbrain morphology (HP:0002418)	4.08263248
4	Molar tooth sign on MRI (HP:0002419)	4.08263248
5	Nephronophthisis (HP:0000090)	4.00632227
6	Type II lissencephaly (HP:0007260)	3.98520905
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.93964612
8	Absent/shortened dynein arms (HP:0200106)	3.93964612
9	Congenital stationary night blindness (HP:0007642)	3.84930816
10	Abnormal respiratory motile cilium morphology (HP:0005938)	3.82951954
11	Abnormal respiratory epithelium morphology (HP:0012253)	3.82951954
12	True hermaphroditism (HP:0010459)	3.80436547
13	Abnormality of the renal medulla (HP:0100957)	3.42886810
14	Abnormal ciliary motility (HP:0012262)	3.25977182
15	Abnormality of the renal cortex (HP:0011035)	3.12145264
16	Tubular atrophy (HP:0000092)	2.97615590
17	Abnormal respiratory motile cilium physiology (HP:0012261)	2.91612968
18	Cystic liver disease (HP:0006706)	2.87490348
19	Abnormal rod and cone electroretinograms (HP:0008323)	2.83816480
20	Lissencephaly (HP:0001339)	2.83080758
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.82373887
22	Abnormal drinking behavior (HP:0030082)	2.82149198
23	Polydipsia (HP:0001959)	2.82149198
24	Attenuation of retinal blood vessels (HP:0007843)	2.71418827
25	Medial flaring of the eyebrow (HP:0010747)	2.71341179
26	Decreased central vision (HP:0007663)	2.59629349
27	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.57085050
28	Chronic hepatic failure (HP:0100626)	2.52025235
29	Cerebellar dysplasia (HP:0007033)	2.49480530
30	Pendular nystagmus (HP:0012043)	2.49390807
31	Inability to walk (HP:0002540)	2.47639078
32	Sclerocornea (HP:0000647)	2.47507398
33	Abnormality of alanine metabolism (HP:0010916)	2.45637115
34	Hyperalaninemia (HP:0003348)	2.45637115
35	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.45637115
36	Abolished electroretinogram (ERG) (HP:0000550)	2.44846588
37	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.39372668
38	Bile duct proliferation (HP:0001408)	2.39029144
39	Abnormal biliary tract physiology (HP:0012439)	2.39029144
40	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.38173758
41	Retinal dysplasia (HP:0007973)	2.37414109
42	Keratoconus (HP:0000563)	2.32079714
43	Increased corneal curvature (HP:0100692)	2.32079714
44	Gait imbalance (HP:0002141)	2.30906924
45	Congenital hepatic fibrosis (HP:0002612)	2.30503856
46	Asplenia (HP:0001746)	2.29657851
47	Nephrogenic diabetes insipidus (HP:0009806)	2.25812161
48	Concave nail (HP:0001598)	2.24411234
49	Furrowed tongue (HP:0000221)	2.23130774
50	Optic nerve hypoplasia (HP:0000609)	2.22201218
51	Large for gestational age (HP:0001520)	2.22171579
52	Rhinitis (HP:0012384)	2.21179185
53	Decreased circulating renin level (HP:0003351)	2.21021126
54	Supernumerary spleens (HP:0009799)	2.20009795
55	Hyperventilation (HP:0002883)	2.16859137
56	Congenital primary aphakia (HP:0007707)	2.15566930
57	Pachygyria (HP:0001302)	2.15275875
58	Polyuria (HP:0000103)	2.14466997
59	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.13247177
60	Congenital, generalized hypertrichosis (HP:0004540)	2.12587055
61	Renal cortical cysts (HP:0000803)	2.12204335
62	Bilateral microphthalmos (HP:0007633)	2.10960517
63	Anencephaly (HP:0002323)	2.09800703
64	Bony spicule pigmentary retinopathy (HP:0007737)	2.08385042
65	Severe muscular hypotonia (HP:0006829)	2.07659203
66	Acute necrotizing encephalopathy (HP:0006965)	2.05272417
67	Male pseudohermaphroditism (HP:0000037)	2.02889121
68	Chorioretinal atrophy (HP:0000533)	2.02178893
69	Methylmalonic acidemia (HP:0002912)	2.00786356
70	3-Methylglutaconic aciduria (HP:0003535)	1.98569813
71	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.97497124
72	Polyphagia (HP:0002591)	1.97101441
73	Optic disc pallor (HP:0000543)	1.94824134
74	Mitochondrial inheritance (HP:0001427)	1.94763891
75	Postaxial foot polydactyly (HP:0001830)	1.94179954
76	Progressive inability to walk (HP:0002505)	1.87438551
77	Progressive cerebellar ataxia (HP:0002073)	1.86924058
78	Confusion (HP:0001289)	1.86855587
79	Hemiparesis (HP:0001269)	1.86706251
80	Aplasia/Hypoplasia of the patella (HP:0006498)	1.86398330
81	Genital tract atresia (HP:0001827)	1.85506534
82	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84730745
83	Progressive macrocephaly (HP:0004481)	1.83202501
84	Patellar aplasia (HP:0006443)	1.82911165
85	Occipital encephalocele (HP:0002085)	1.82034008
86	Lipid accumulation in hepatocytes (HP:0006561)	1.81600443
87	Abnormal number of erythroid precursors (HP:0012131)	1.81467956
88	Methylmalonic aciduria (HP:0012120)	1.80161623
89	Abnormality of the labia minora (HP:0012880)	1.80105529
90	Vaginal atresia (HP:0000148)	1.78860563
91	Abnormal urine output (HP:0012590)	1.78112335
92	Agitation (HP:0000713)	1.77908211
93	Clumsiness (HP:0002312)	1.77127606
94	Tachypnea (HP:0002789)	1.74780775
95	Increased CSF lactate (HP:0002490)	1.73334973
96	Hyperglycinuria (HP:0003108)	1.72990072
97	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.72600563
98	Hypoplasia of the fovea (HP:0007750)	1.72600563
99	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.72475824
100	Broad-based gait (HP:0002136)	1.71016070

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.85611550
2	ADRBK2	3.44927836
3	PINK1	3.41234616
4	TLK1	3.10043402
5	WNK3	2.63625691
6	CASK	2.54330368
7	WNK4	2.51879603
8	ZAK	2.48001566
9	GRK1	2.43141543
10	BMPR1B	2.29730779
11	MAP4K2	2.16564664
12	MAPK13	2.13083492
13	TAOK3	1.98919445
14	MAP3K4	1.96535911
15	DYRK2	1.95588659
16	MAPK15	1.95368906
17	INSRR	1.89697381
18	DAPK2	1.81798151
19	MARK1	1.79290768
20	ACVR1B	1.71811841
21	MAP2K7	1.65373818
22	NUAK1	1.53199360
23	OXSR1	1.49968438
24	ADRBK1	1.35796867
25	PHKG2	1.28147736
26	PHKG1	1.28147736
27	TIE1	1.26381789
28	STK39	1.24456690
29	TXK	1.21721251
30	TNIK	1.16331084
31	NME1	1.08574761
32	NTRK2	1.07991346
33	STK16	1.06485426
34	STK11	1.03970675
35	PLK4	1.03390383
36	PRKCG	1.02033059
37	PAK3	1.01304823
38	PRKCE	0.99893357
39	BCR	0.98741166
40	TGFBR1	0.98180474
41	TRIM28	0.95229858
42	SIK2	0.93915913
43	CSNK1G2	0.88628427
44	BCKDK	0.82046801
45	GRK7	0.81889611
46	PIK3CA	0.81513129
47	NTRK3	0.79546189
48	BRSK2	0.74448075
49	PLK2	0.74371214
50	VRK1	0.73862922
51	MAPKAPK5	0.73330633
52	CSNK1G3	0.70464643
53	NEK2	0.67995818
54	RPS6KA5	0.67813714
55	CAMKK2	0.66258263
56	PRKCZ	0.65489212
57	OBSCN	0.65135693
58	CSNK1G1	0.64412749
59	CAMK2A	0.62251973
60	STK38L	0.61407937
61	MAP2K4	0.58850784
62	PRKCI	0.58567649
63	KIT	0.58032051
64	PKN1	0.57573683
65	CSNK1A1L	0.56687870
66	RPS6KA6	0.56680968
67	PRKACA	0.56138168
68	CAMK1	0.55836509
69	PRKCQ	0.55808589
70	PTK2B	0.55749772
71	MST4	0.55469987
72	MKNK2	0.55320449
73	CSNK1A1	0.54099341
74	MAP2K6	0.52937279
75	EPHA3	0.52682084
76	MAPKAPK3	0.52635007
77	PAK6	0.50424437
78	DYRK3	0.44803262
79	ERBB2	0.43365475
80	PRKG1	0.43162166
81	MUSK	0.40905661
82	CAMK4	0.39467407
83	PRKCA	0.39046032
84	PRKAA1	0.38084895
85	FLT3	0.37796219
86	SGK494	0.37092215
87	SGK223	0.37092215
88	WEE1	0.34792407
89	IRAK1	0.34604261
90	PLK1	0.34310028
91	DYRK1A	0.34215270
92	PRKAA2	0.34172185
93	CHUK	0.33146450
94	CDK19	0.32726297
95	EPHA4	0.32532695
96	MAP3K11	0.31919809
97	GRK5	0.31183450
98	IKBKB	0.30553275
99	MAP2K2	0.29756127
100	PRKACB	0.29319497

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	3.10913686
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.08294540
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.78128158
4	Phototransduction_Homo sapiens_hsa04744	2.76020737
5	Nicotine addiction_Homo sapiens_hsa05033	2.40994954
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.32809823
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.31231335
8	Parkinsons disease_Homo sapiens_hsa05012	2.20564643
9	Caffeine metabolism_Homo sapiens_hsa00232	2.19561132
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18615026
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.15217579
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.09355305
13	Butanoate metabolism_Homo sapiens_hsa00650	2.08743564
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.98834613
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.95675217
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.95505013
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.94112508
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.92995618
19	Olfactory transduction_Homo sapiens_hsa04740	1.79717443
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.77920822
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.67126621
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.65362554
23	Huntingtons disease_Homo sapiens_hsa05016	1.60829754
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.58429788
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56159060
26	Protein export_Homo sapiens_hsa03060	1.54761319
27	Morphine addiction_Homo sapiens_hsa05032	1.52560358
28	Alzheimers disease_Homo sapiens_hsa05010	1.48189159
29	Taste transduction_Homo sapiens_hsa04742	1.44129346
30	Basal transcription factors_Homo sapiens_hsa03022	1.35067159
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.32284495
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.31899824
33	RNA polymerase_Homo sapiens_hsa03020	1.19817611
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.19447598
35	GABAergic synapse_Homo sapiens_hsa04727	1.19131177
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.17273409
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.17066114
38	Serotonergic synapse_Homo sapiens_hsa04726	1.09105432
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08299022
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.08015494
41	Sulfur relay system_Homo sapiens_hsa04122	1.06782754
42	Peroxisome_Homo sapiens_hsa04146	1.04978002
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.04942467
44	Glutamatergic synapse_Homo sapiens_hsa04724	1.02233738
45	Circadian entrainment_Homo sapiens_hsa04713	0.98569447
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.98431000
47	Insulin secretion_Homo sapiens_hsa04911	0.97322051
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.95612203
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.95563069
50	Homologous recombination_Homo sapiens_hsa03440	0.95293897
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.94252992
52	RNA degradation_Homo sapiens_hsa03018	0.92801305
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92739737
54	Retinol metabolism_Homo sapiens_hsa00830	0.89524440
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86320500
56	Histidine metabolism_Homo sapiens_hsa00340	0.85633383
57	ABC transporters_Homo sapiens_hsa02010	0.84866451
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.84849920
59	Ribosome_Homo sapiens_hsa03010	0.81785433
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80455059
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.75021196
62	Salivary secretion_Homo sapiens_hsa04970	0.73117092
63	Cocaine addiction_Homo sapiens_hsa05030	0.72172064
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.71764677
65	Regulation of autophagy_Homo sapiens_hsa04140	0.70621315
66	Propanoate metabolism_Homo sapiens_hsa00640	0.69367314
67	Long-term depression_Homo sapiens_hsa04730	0.68753538
68	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62987600
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.62777416
70	Metabolic pathways_Homo sapiens_hsa01100	0.60822964
71	Mineral absorption_Homo sapiens_hsa04978	0.59578141
72	Purine metabolism_Homo sapiens_hsa00230	0.59031699
73	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.58615268
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54503546
75	Dopaminergic synapse_Homo sapiens_hsa04728	0.54494206
76	Circadian rhythm_Homo sapiens_hsa04710	0.54181644
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53065965
78	Gastric acid secretion_Homo sapiens_hsa04971	0.50458165
79	One carbon pool by folate_Homo sapiens_hsa00670	0.49736342
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.48526968
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.47459497
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.46672418
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.46630925
84	Sulfur metabolism_Homo sapiens_hsa00920	0.46048258
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.45480726
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43248500
87	Amphetamine addiction_Homo sapiens_hsa05031	0.42488350
88	Steroid biosynthesis_Homo sapiens_hsa00100	0.40973619
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.40194781
90	Asthma_Homo sapiens_hsa05310	0.39259591
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.38506402
92	Pyrimidine metabolism_Homo sapiens_hsa00240	0.36404095
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35995019
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.35823497
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35090239
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34933051
97	Cholinergic synapse_Homo sapiens_hsa04725	0.33527420
98	Fatty acid degradation_Homo sapiens_hsa00071	0.33438627
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.32835485
100	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.26843109

KRT42P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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