KRT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intermediate filament organization (GO:0045109)8.17043200
2keratinocyte differentiation (GO:0030216)7.01150945
3peptide cross-linking (GO:0018149)6.96001479
4multicellular organismal water homeostasis (GO:0050891)6.89779719
5bundle of His cell to Purkinje myocyte communication (GO:0086069)6.83465150
6* epidermis development (GO:0008544)6.16171016
7surfactant homeostasis (GO:0043129)6.10879971
8keratinocyte development (GO:0003334)5.95242108
9skin morphogenesis (GO:0043589)5.71979484
10water homeostasis (GO:0030104)5.71911342
11epidermal cell differentiation (GO:0009913)5.50526438
12* cell-substrate junction assembly (GO:0007044)5.41766915
13negative regulation of keratinocyte proliferation (GO:0010839)5.30732877
14keratinocyte proliferation (GO:0043616)5.26919899
15gap junction assembly (GO:0016264)5.25666526
16regulation of hair follicle development (GO:0051797)5.08628170
17chemical homeostasis within a tissue (GO:0048875)5.04755306
18intermediate filament cytoskeleton organization (GO:0045104)4.98386442
19polarized epithelial cell differentiation (GO:0030859)4.87525544
20intermediate filament-based process (GO:0045103)4.80906346
21positive regulation of hair follicle development (GO:0051798)4.67176880
22positive regulation of hair cycle (GO:0042635)4.67176880
23adhesion of symbiont to host cell (GO:0044650)4.63739383
24virion attachment to host cell (GO:0019062)4.63739383
25ectoderm development (GO:0007398)4.36786953
26negative regulation of chondrocyte differentiation (GO:0032331)4.27733339
27positive regulation of keratinocyte differentiation (GO:0045618)4.17843133
28regulation of hair cycle (GO:0042634)4.10113464
29positive regulation of epidermis development (GO:0045684)4.09134396
30atrioventricular valve morphogenesis (GO:0003181)4.02223155
31protein localization to endosome (GO:0036010)4.01878503
32cell adhesion mediated by integrin (GO:0033627)3.98088847
33skin development (GO:0043588)3.95668336
34planar cell polarity pathway involved in neural tube closure (GO:0090179)3.87721545
35adhesion of symbiont to host (GO:0044406)3.78534648
36negative regulation of cell fate specification (GO:0009996)3.74014205
37lateral sprouting from an epithelium (GO:0060601)3.71238077
38hair follicle morphogenesis (GO:0031069)3.63944710
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.60114675
40regulation of keratinocyte proliferation (GO:0010837)3.59378042
41hypotonic response (GO:0006971)3.54201734
42epithelial cell-cell adhesion (GO:0090136)3.44516865
43regulation of epidermis development (GO:0045682)3.44281524
44regulation of ruffle assembly (GO:1900027)3.43992537
45positive regulation of epidermal cell differentiation (GO:0045606)3.42967603
46molting cycle process (GO:0022404)3.34964488
47hair cycle process (GO:0022405)3.34964488
48establishment of tissue polarity (GO:0007164)3.32063078
49establishment of planar polarity (GO:0001736)3.32063078
50L-serine transport (GO:0015825)3.28469907
51regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.26321372
52eyelid development in camera-type eye (GO:0061029)3.25234241
53morphogenesis of embryonic epithelium (GO:0016331)3.16529323
54bone trabecula formation (GO:0060346)3.14328611
55focal adhesion assembly (GO:0048041)3.13098859
56cell-substrate adherens junction assembly (GO:0007045)3.13098859
57negative regulation of axon extension involved in axon guidance (GO:0048843)3.09991830
58* epithelium development (GO:0060429)3.08390047
59regulation of phospholipase A2 activity (GO:0032429)3.06886244
60renal system development (GO:0072001)3.02210456
61non-canonical Wnt signaling pathway (GO:0035567)3.01161312
62odontogenesis (GO:0042476)2.98803583
63odontogenesis of dentin-containing tooth (GO:0042475)2.97555217
64endodermal cell differentiation (GO:0035987)2.95039861
65hair follicle development (GO:0001942)2.94675769
66mesodermal cell differentiation (GO:0048333)2.93522414
67regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.92652124
68negative regulation of cartilage development (GO:0061037)2.92289888
69regulation of cardioblast differentiation (GO:0051890)2.89874282
70serine transport (GO:0032329)2.80930907
71negative regulation of cell fate commitment (GO:0010454)2.77460050
72adherens junction organization (GO:0034332)2.76998469
73regulation of endothelial cell chemotaxis (GO:2001026)2.75944408
74G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.75223537
75cell communication involved in cardiac conduction (GO:0086065)2.74534255
76regulation of heart rate by cardiac conduction (GO:0086091)2.74450826
77ventricular cardiac muscle cell action potential (GO:0086005)2.74367354
78regulation of transforming growth factor beta2 production (GO:0032909)2.74227991
79renal filtration (GO:0097205)2.72786124
80mitotic G1 DNA damage checkpoint (GO:0031571)2.72089030
81interferon-gamma secretion (GO:0072643)2.71190064
82adherens junction assembly (GO:0034333)2.70869959
83mammary gland epithelial cell proliferation (GO:0033598)2.69679468
84gland morphogenesis (GO:0022612)2.67881732
85membrane raft organization (GO:0031579)2.67647152
86epithelial cell differentiation involved in prostate gland development (GO:0060742)2.67353602
87intestinal epithelial cell development (GO:0060576)2.65956990
88membrane tubulation (GO:0097320)2.65800816
89regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.65049276
90epithelial cell fate commitment (GO:0072148)2.61207946
91cytoskeletal anchoring at plasma membrane (GO:0007016)2.60219979
92epithelial cell proliferation (GO:0050673)2.59816455
93regulation of G0 to G1 transition (GO:0070316)2.58824286
94positive regulation of monocyte chemotaxis (GO:0090026)2.58124789
95cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.57070760
96mitotic G1/S transition checkpoint (GO:0044819)2.56995933
97ephrin receptor signaling pathway (GO:0048013)2.53378838
98regulation of epidermal cell differentiation (GO:0045604)2.53163224
99morphogenesis of an epithelial fold (GO:0060571)2.53158003
100negative regulation of stem cell proliferation (GO:2000647)2.52190320
101cardiac right ventricle morphogenesis (GO:0003215)2.52104792
102endosome organization (GO:0007032)2.51761208
103lung-associated mesenchyme development (GO:0060484)2.49684945
104glial cell proliferation (GO:0014009)2.48340755
105negative regulation of epidermis development (GO:0045683)2.48065670
106anatomical structure regression (GO:0060033)2.48009527
107negative regulation of catenin import into nucleus (GO:0035414)2.47334904
108regulation of metalloenzyme activity (GO:0048552)2.46118048
109Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.44706178
110wound healing (GO:0042060)2.44087980
111long-chain fatty acid biosynthetic process (GO:0042759)2.44024756
112* cell junction organization (GO:0034330)2.43062544
113apoptotic process involved in morphogenesis (GO:0060561)2.39991400
114fibrinolysis (GO:0042730)2.39602379
115oocyte development (GO:0048599)2.38710013
116wound healing, spreading of epidermal cells (GO:0035313)2.37727066
117regulation of establishment of planar polarity (GO:0090175)2.34120056
118neuron projection extension involved in neuron projection guidance (GO:1902284)2.33240212
119axon extension involved in axon guidance (GO:0048846)2.33240212
120* cell junction assembly (GO:0034329)2.33132268
121regulation of keratinocyte differentiation (GO:0045616)2.32812541
122negative regulation of axon guidance (GO:1902668)2.32066162
123outer ear morphogenesis (GO:0042473)2.31736154
124skeletal muscle fiber development (GO:0048741)2.31557069
125cell surface receptor signaling pathway involved in heart development (GO:0061311)2.31179068
126regulation of cell fate specification (GO:0042659)2.30956744
127positive regulation of protein export from nucleus (GO:0046827)2.30241889
128positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.30057906
129tooth mineralization (GO:0034505)2.29827406
130dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.29726256
131* hemidesmosome assembly (GO:0031581)16.5115599
132molting cycle (GO:0042303)14.5475610
133hair cycle (GO:0042633)14.5475610
134desmosome organization (GO:0002934)13.9236749
135keratinization (GO:0031424)12.6938179
136establishment of skin barrier (GO:0061436)11.0420215
137regulation of water loss via skin (GO:0033561)10.3372199

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.20860056
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.83946555
3ZNF263_19887448_ChIP-Seq_K562_Human2.83652192
4* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.65059486
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61160625
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.45583396
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.24180481
8TP63_17297297_ChIP-ChIP_HaCaT_Human17.3992367
9TRIM28_21343339_ChIP-Seq_HEK293_Human1.96602630
10* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.91990883
11* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.91990883
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.91217586
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90176654
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.64144024
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63315693
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60697351
17RACK7_27058665_Chip-Seq_MCF-7_Human1.50015283
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48978709
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36573984
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32208433
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30403299
22* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28173379
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24891508
24* TP63_22573176_ChIP-Seq_HFKS_Human1.24842085
25* ATF3_27146783_Chip-Seq_COLON_Human1.22116025
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21087184
27KLF5_25053715_ChIP-Seq_YYC3_Human1.20580241
28ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18749720
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.17652233
30AR_21572438_ChIP-Seq_LNCaP_Human1.17542391
31* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17056389
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16462701
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.15433216
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15329950
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12696845
36CJUN_26792858_Chip-Seq_BT549_Human1.12354563
37CLOCK_20551151_ChIP-Seq_293T_Human1.12324816
38* TP63_23658742_ChIP-Seq_EP156T_Human1.10876564
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10458845
40* UBF1/2_26484160_Chip-Seq_HMECs_Human1.10110320
41LXR_22292898_ChIP-Seq_THP-1_Human1.09785781
42* TP53_20018659_ChIP-ChIP_R1E_Mouse1.09680125
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08637396
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.08482678
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08423003
46HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07436447
47SOX2_20726797_ChIP-Seq_SW620_Human1.06811826
48EGR1_19032775_ChIP-ChIP_M12_Human1.05914296
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05193942
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05087165
51ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03174227
52* CTCF_27219007_Chip-Seq_Bcells_Human0.96074478
53ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94540547
54RXR_22108803_ChIP-Seq_LS180_Human0.94224263
55KDM2B_26808549_Chip-Seq_K562_Human0.93186777
56P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93175891
57RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92773943
58GATA2_21666600_ChIP-Seq_HMVEC_Human0.92368752
59SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91981537
60JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91947561
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90069009
62KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89064041
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88352619
64* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87379966
65* SA1_27219007_Chip-Seq_ERYTHROID_Human0.86582457
66GATA6_25053715_ChIP-Seq_YYC3_Human0.86572926
67GATA3_24758297_ChIP-Seq_MCF-7_Human0.85301220
68EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85085355
69ERG_21242973_ChIP-ChIP_JURKAT_Human0.84273201
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82850248
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82845940
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82596741
73TP53_16413492_ChIP-PET_HCT116_Human0.82500934
74KDM2B_26808549_Chip-Seq_JURKAT_Human0.82177943
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82067504
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81810758
77KDM2B_26808549_Chip-Seq_DND41_Human0.81713638
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80598715
79ESR1_20079471_ChIP-ChIP_T-47D_Human0.80502422
80* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79359152
81JARID2_20075857_ChIP-Seq_MESCs_Mouse0.78336133
82TP53_18474530_ChIP-ChIP_U2OS_Human0.78234799
83TP53_22127205_ChIP-Seq_IMR90_Human0.78220080
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76676356
85RNF2_27304074_Chip-Seq_ESCs_Mouse0.76604051
86* CTCF_20526341_ChIP-Seq_ESCs_Human0.75490679
87* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.75213860
88* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75043927
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74770406
90TBX20_22080862_ChIP-Seq_HEART_Mouse0.73487966
91AR_21909140_ChIP-Seq_LNCAP_Human0.72562840
92* AHR_22903824_ChIP-Seq_MCF-7_Human0.71758388
93NANOG_18555785_ChIP-Seq_MESCs_Mouse0.70844260
94P68_20966046_ChIP-Seq_HELA_Human0.70494073
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.69610081
96TCF7_22412390_ChIP-Seq_EML_Mouse0.69478555
97RNF2_18974828_ChIP-Seq_MESCs_Mouse0.69354186
98EZH2_18974828_ChIP-Seq_MESCs_Mouse0.69354186
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.69130322
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.68769875
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68411748
102EZH2_27294783_Chip-Seq_ESCs_Mouse0.67948891
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.67292765
104EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.67172106
105GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.66562958
106GATA4_25053715_ChIP-Seq_YYC3_Human0.65804496
107PPAR_26484153_Chip-Seq_NCI-H1993_Human0.65710410
108EZH2_27304074_Chip-Seq_ESCs_Mouse0.65656585
109BCOR_27268052_Chip-Seq_Bcells_Human0.65318564
110E2F1_20622854_ChIP-Seq_HELA_Human0.64725779
111KLF4_18555785_ChIP-Seq_MESCs_Mouse0.64725168
112RING1B_27294783_Chip-Seq_ESCs_Mouse0.64337428
113EGR1_19374776_ChIP-ChIP_THP-1_Human0.63760842
114SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.62762900
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.62376981
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.60893425
117MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.60660666
118CEBPB_22108803_ChIP-Seq_LS180_Human0.59339602
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.59330067
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.58333345
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.58265097
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57520294
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.57464688
124TBX20_22328084_ChIP-Seq_HEART_Mouse0.57353503
125ELK4_26923725_Chip-Seq_MESODERM_Mouse0.56956590
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.55531281
127SMC4_20622854_ChIP-Seq_HELA_Human0.52923309
128* TP53_23651856_ChIP-Seq_MEFs_Mouse0.52560450
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.51799689
130NANOG_18692474_ChIP-Seq_MEFs_Mouse0.51526762
131CHD1_26751641_Chip-Seq_LNCaP_Human0.50977927
132KAP1_27257070_Chip-Seq_ESCs_Mouse0.50350789
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.46761720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology5.84956401
2MP0005275_abnormal_skin_tensile5.82100756
3MP0002796_impaired_skin_barrier5.78826421
4MP0002254_reproductive_system_inflammat4.62793735
5MP0000383_abnormal_hair_follicle4.33277805
6MP0010234_abnormal_vibrissa_follicle4.28924681
7MP0005501_abnormal_skin_physiology3.67606528
8MP0010678_abnormal_skin_adnexa3.64545616
9MP0002060_abnormal_skin_morphology3.58518970
10MP0003705_abnormal_hypodermis_morpholog3.53831094
11MP0002098_abnormal_vibrissa_morphology3.33494612
12* MP0001216_abnormal_epidermal_layer3.27173660
13MP0004381_abnormal_hair_follicle3.02542093
14MP0002234_abnormal_pharynx_morphology3.00108085
15MP0003941_abnormal_skin_development2.99874829
16MP0003453_abnormal_keratinocyte_physiol2.97013746
17MP0000647_abnormal_sebaceous_gland2.87485268
18MP0010771_integument_phenotype2.78579871
19MP0000377_abnormal_hair_follicle2.66479828
20MP0000427_abnormal_hair_cycle2.64528805
21* MP0000467_abnormal_esophagus_morphology2.64015350
22* MP0000762_abnormal_tongue_morphology2.42404275
23MP0003566_abnormal_cell_adhesion2.25685977
24MP0001849_ear_inflammation2.19763930
25MP0004947_skin_inflammation2.15552872
26MP0005409_darkened_coat_color1.86553824
27MP0001346_abnormal_lacrimal_gland1.84234739
28MP0008260_abnormal_autophagy1.84111238
29MP0009053_abnormal_anal_canal1.83630002
30MP0009931_abnormal_skin_appearance1.76924649
31MP0000566_synostosis1.76137621
32MP0001243_abnormal_dermal_layer1.74738927
33MP0010030_abnormal_orbit_morphology1.59843179
34MP0001191_abnormal_skin_condition1.51220597
35MP0000367_abnormal_coat/_hair1.44932286
36MP0001851_eye_inflammation1.36082991
37MP0008789_abnormal_olfactory_epithelium1.32339647
38MP0004272_abnormal_basement_membrane1.22864969
39MP0004185_abnormal_adipocyte_glucose1.17872190
40MP0001340_abnormal_eyelid_morphology1.09705804
41MP0005360_urolithiasis1.08222511
42MP0005023_abnormal_wound_healing1.04021427
43MP0000537_abnormal_urethra_morphology0.99212180
44MP0000538_abnormal_urinary_bladder0.96967238
45MP0010352_gastrointestinal_tract_polyps0.96143450
46MP0005394_taste/olfaction_phenotype0.95519034
47MP0005499_abnormal_olfactory_system0.95519034
48MP0002282_abnormal_trachea_morphology0.92905968
49MP0004885_abnormal_endolymph0.91687133
50MP0004782_abnormal_surfactant_physiolog0.90209678
51MP0005075_abnormal_melanosome_morpholog0.88142298
52MP0008438_abnormal_cutaneous_collagen0.86786019
53MP0000462_abnormal_digestive_system0.83373660
54MP0005257_abnormal_intraocular_pressure0.82889083
55MP0003315_abnormal_perineum_morphology0.81859964
56MP0002233_abnormal_nose_morphology0.81212966
57MP0000858_altered_metastatic_potential0.79956277
58* MP0003755_abnormal_palate_morphology0.79446004
59MP0002177_abnormal_outer_ear0.79427092
60MP0002877_abnormal_melanocyte_morpholog0.79119408
61MP0004019_abnormal_vitamin_homeostasis0.76378361
62MP0000627_abnormal_mammary_gland0.75066924
63MP0005076_abnormal_cell_differentiation0.67140859
64MP0005451_abnormal_body_composition0.62544975
65MP0002095_abnormal_skin_pigmentation0.62211698
66MP0009780_abnormal_chondrocyte_physiolo0.60499117
67* MP0002111_abnormal_tail_morphology0.59766143
68MP0003191_abnormal_cellular_cholesterol0.59657412
69MP0006054_spinal_hemorrhage0.59376655
70MP0000465_gastrointestinal_hemorrhage0.58548661
71MP0000733_abnormal_muscle_development0.57471509
72MP0009379_abnormal_foot_pigmentation0.57105924
73MP0003045_fibrosis0.55879401
74MP0002249_abnormal_larynx_morphology0.54796273
75MP0001188_hyperpigmentation0.51949124
76MP0000432_abnormal_head_morphology0.51756703
77MP0003806_abnormal_nucleotide_metabolis0.51255495
78MP0003385_abnormal_body_wall0.50435170
79MP0002089_abnormal_postnatal_growth/wei0.48800955
80MP0003091_abnormal_cell_migration0.48745231
81MP0001784_abnormal_fluid_regulation0.48608677
82MP0003329_amyloid_beta_deposits0.47435282
83MP0003937_abnormal_limbs/digits/tail_de0.46499583
84MP0005197_abnormal_uvea_morphology0.46422270
85MP0004264_abnormal_extraembryonic_tissu0.45634422
86MP0003935_abnormal_craniofacial_develop0.43935336
87MP0000003_abnormal_adipose_tissue0.43422463
88MP0003786_premature_aging0.43112816
89MP0005508_abnormal_skeleton_morphology0.42928314
90MP0000428_abnormal_craniofacial_morphol0.42123798
91MP0005367_renal/urinary_system_phenotyp0.41996546
92MP0000516_abnormal_urinary_system0.41996546
93MP0009840_abnormal_foam_cell0.41513522
94MP0004134_abnormal_chest_morphology0.41193976
95MP0000750_abnormal_muscle_regeneration0.41075672
96MP0009250_abnormal_appendicular_skeleto0.40690267
97MP0000613_abnormal_salivary_gland0.39285493
98MP0002697_abnormal_eye_size0.38980433
99MP0005193_abnormal_anterior_eye0.38597032
100MP0001348_abnormal_lacrimal_gland0.38480491
101MP0002896_abnormal_bone_mineralization0.37471040
102MP0009384_cardiac_valve_regurgitation0.36781181
103MP0004858_abnormal_nervous_system0.36056918
104MP0010368_abnormal_lymphatic_system0.35905726
105MP0003828_pulmonary_edema0.35805609
106MP0005621_abnormal_cell_physiology0.35279893
107MP0004197_abnormal_fetal_growth/weight/0.33340360
108MP0001661_extended_life_span0.32924060
109* MP0002109_abnormal_limb_morphology0.31573389
110MP0008961_abnormal_basal_metabolism0.30154993
111MP0005164_abnormal_response_to0.30144263
112MP0001765_abnormal_ion_homeostasis0.30143608
113MP0003638_abnormal_response/metabolism_0.29450039
114MP0001299_abnormal_eye_distance/0.29352397
115MP0003448_altered_tumor_morphology0.29292420
116MP0005666_abnormal_adipose_tissue0.29212042
117MP0005375_adipose_tissue_phenotype0.29036781
118MP0003950_abnormal_plasma_membrane0.27728158
119MP0004883_abnormal_blood_vessel0.26818353
120MP0002006_tumorigenesis0.25431978
121MP0000678_abnormal_parathyroid_gland0.25190290
122MP0003300_gastrointestinal_ulcer0.24991813
123MP0002009_preneoplasia0.24985543
124MP0003763_abnormal_thymus_physiology0.24877359
125MP0005248_abnormal_Harderian_gland0.21717842
126MP0001958_emphysema0.20374242
127MP0002115_abnormal_skeleton_extremities0.20353596
128MP0002909_abnormal_adrenal_gland0.19829437

Predicted human phenotypes

RankGene SetZ-score
1* Milia (HP:0001056)9.73242982
2Fragile nails (HP:0001808)9.21640803
3Onycholysis (HP:0001806)9.09435212
4* Plantar hyperkeratosis (HP:0007556)8.07875678
5Hypotrichosis (HP:0001006)7.35198591
6Atrophic scars (HP:0001075)7.22103535
7Pili torti (HP:0003777)6.32047936
8Woolly hair (HP:0002224)6.20028301
9Abnormality of nail color (HP:0100643)6.14268619
10* Palmoplantar hyperkeratosis (HP:0000972)5.99095376
11* Palmar hyperkeratosis (HP:0010765)5.62978434
12* Nail dystrophy (HP:0008404)5.57461647
13* Thick nail (HP:0001805)5.47888073
14Alopecia of scalp (HP:0002293)5.41106348
15Increased IgE level (HP:0003212)5.16877220
16Right ventricular cardiomyopathy (HP:0011663)5.02949127
17* Abnormal blistering of the skin (HP:0008066)4.72074891
18Conjunctival hamartoma (HP:0100780)4.60378591
19Abnormal hair laboratory examination (HP:0003328)3.94317344
20Fragile skin (HP:0001030)3.67549260
21Follicular hyperkeratosis (HP:0007502)3.55631712
22Erythroderma (HP:0001019)3.54810407
23Erythema (HP:0010783)3.47778505
24Abnormality of the axillary hair (HP:0100134)3.44963849
25Abnormality of secondary sexual hair (HP:0009888)3.44963849
26Popliteal pterygium (HP:0009756)3.39488281
27Aplasia cutis congenita (HP:0001057)3.33206006
28Abnormality of placental membranes (HP:0011409)3.26170944
29Amniotic constriction ring (HP:0009775)3.26170944
30Lip pit (HP:0100267)3.06452016
31Oligodontia (HP:0000677)3.04914735
32Hypoplasia of dental enamel (HP:0006297)3.03909007
33Natal tooth (HP:0000695)2.98369676
34Abnormality of the labia majora (HP:0012881)2.96665100
35Hamartoma of the eye (HP:0010568)2.96182719
36Advanced eruption of teeth (HP:0006288)2.83958599
37* Ridged nail (HP:0001807)2.83797245
38Sparse eyelashes (HP:0000653)2.81856578
39Congenital ichthyosiform erythroderma (HP:0007431)2.78628034
40Amelogenesis imperfecta (HP:0000705)2.76870266
41Ectropion (HP:0000656)2.73043141
42Epidermoid cyst (HP:0200040)2.70037999
43Increased connective tissue (HP:0009025)2.68390578
44Parakeratosis (HP:0001036)2.64480149
45Corneal erosion (HP:0200020)2.62134358
46Esophageal atresia (HP:0002032)2.57431730
47Blepharitis (HP:0000498)2.56771201
48* Palmoplantar keratoderma (HP:0000982)2.55664398
49Curly hair (HP:0002212)2.55066564
50Oral leukoplakia (HP:0002745)2.52099610
51Anonychia (HP:0001798)2.43504260
52Ventricular tachycardia (HP:0004756)2.37198520
53Hypohidrosis (HP:0000966)2.34866927
54Type 1 muscle fiber predominance (HP:0003803)2.31046600
55Pterygium (HP:0001059)2.30032656
56* Hyperhidrosis (HP:0000975)2.27874596
57Sparse scalp hair (HP:0002209)2.27803034
58Gangrene (HP:0100758)2.26015526
59Xerostomia (HP:0000217)2.25328364
60Split foot (HP:0001839)2.24741664
61Breast hypoplasia (HP:0003187)2.24575469
62Acanthosis nigricans (HP:0000956)2.20436476
63Absent hair (HP:0002298)2.19425095
64Distal lower limb muscle weakness (HP:0009053)2.17768284
65Down-sloping shoulders (HP:0200021)2.17156634
66Carious teeth (HP:0000670)2.16371167
67Absent eyelashes (HP:0000561)2.11804521
68Multifactorial inheritance (HP:0001426)2.08885926
69Septate vagina (HP:0001153)2.06261916
70Labial hypoplasia (HP:0000066)2.06174269
71Hyporeflexia of lower limbs (HP:0002600)2.05458328
72Selective tooth agenesis (HP:0001592)2.03793645
73Pruritus (HP:0000989)2.01351062
74Round ear (HP:0100830)1.99741667
75* Skin ulcer (HP:0200042)1.99225763
76Nasolacrimal duct obstruction (HP:0000579)1.97617647
77Ankyloglossia (HP:0010296)1.96949708
78* Abnormality of the fingernails (HP:0001231)1.94236759
79Aplasia involving bones of the upper limbs (HP:0009823)1.94168066
80Aplasia of the phalanges of the hand (HP:0009802)1.94168066
81Aplasia involving bones of the extremities (HP:0009825)1.94168066
82Abnormality of hair growth rate (HP:0011363)1.94130977
83Slow-growing hair (HP:0002217)1.94130977
84Hypoplastic female external genitalia (HP:0012815)1.92636677
85Hypodontia (HP:0000668)1.89832444
86Premature rupture of membranes (HP:0001788)1.89266513
87* Abnormality of the neuromuscular junction (HP:0003398)1.86964373
88* Fatigable weakness (HP:0003473)1.86964373
89Laryngomalacia (HP:0001601)1.86732416
90Cheilitis (HP:0100825)1.86695408
91Corneal dystrophy (HP:0001131)1.85691180
92Achilles tendon contracture (HP:0001771)1.82302554
93Abnormality of the dental root (HP:0006486)1.81039449
94Taurodontia (HP:0000679)1.81039449
95Abnormality of permanent molar morphology (HP:0011071)1.81039449
96Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.80526177
97Abnormality of the parietal bone (HP:0002696)1.79330703
98Brittle hair (HP:0002299)1.77328085
99Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76938621
100Ureteral stenosis (HP:0000071)1.76603283
101Hamartoma (HP:0010566)1.76404094
102Squamous cell carcinoma (HP:0002860)1.75533379
103Hypoplasia of the uterus (HP:0000013)1.70203331
104Trismus (HP:0000211)1.69970224
105Melanocytic nevus (HP:0000995)1.68728371
106Abnormality of the gastric mucosa (HP:0004295)1.68716293
107Conical tooth (HP:0000698)1.66577656
108Abnormality of molar morphology (HP:0011070)1.66418518
109Abnormality of molar (HP:0011077)1.66418518
110Abnormality of the Achilles tendon (HP:0005109)1.65545969
111Bronchomalacia (HP:0002780)1.63899055
112Duplicated collecting system (HP:0000081)1.63589870
113Autoamputation (HP:0001218)1.61600511
114Ureteral obstruction (HP:0006000)1.57839589
115Hoarse voice (HP:0001609)1.57711095
116Hypoplastic labia majora (HP:0000059)1.55796501
117Dehydration (HP:0001944)1.55541991
118Abnormality of the dental pulp (HP:0006479)1.55325334
119Ureteral duplication (HP:0000073)1.53604966
120Abnormality of the lacrimal duct (HP:0011481)1.53363037
121Neurofibrillary tangles (HP:0002185)1.52287229
122Skin pits (HP:0100276)1.52149904
123Shallow orbits (HP:0000586)1.51631837
124Abnormality of the salivary glands (HP:0010286)1.48780816
125Hypergammaglobulinemia (HP:0010702)1.48047908
126Distal arthrogryposis (HP:0005684)1.47260360
127Lack of skin elasticity (HP:0100679)1.46691094
128Morphological abnormality of the middle ear (HP:0008609)1.46249278
129Abnormality of oral frenula (HP:0000190)1.45607269
130Congenital, generalized hypertrichosis (HP:0004540)1.45475478
131Ventricular fibrillation (HP:0001663)1.45463946
132Mildly elevated creatine phosphokinase (HP:0008180)1.44494454
133Spinal rigidity (HP:0003306)1.43252528
134Unilateral renal agenesis (HP:0000122)1.42035754
135Dry hair (HP:0011359)1.42032244
136Verrucae (HP:0200043)1.41862259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.56735193
2MAP3K34.23125922
3MST1R3.88415315
4MAPKAPK33.43509931
5FER3.40167242
6TGFBR13.17759141
7ARAF3.11513728
8ERN13.02892109
9NTRK12.86966581
10LATS12.83822972
11TRIB32.79067191
12MAP3K22.42799822
13EPHB12.25615779
14EPHB22.21642051
15NME12.15111674
16FLT32.06763141
17TAOK12.02060895
18RIPK11.99514129
19EPHA31.99349420
20RPS6KB21.97934002
21TTN1.93720335
22MAPK151.91327943
23FGFR21.89923284
24DMPK1.87185380
25RPS6KA41.86803566
26EEF2K1.84720596
27MAP3K111.84342561
28PKN21.71248100
29SMG11.64749140
30LMTK21.60045688
31FGFR41.57910962
32MET1.52014999
33PIK3CG1.49186905
34TRPM71.41160519
35MAP3K11.36702684
36PTK61.35660505
37MST41.34437395
38LRRK21.24074931
39PTK21.18998539
40MAP3K131.17895555
41SIK11.16878162
42FGFR11.15387242
43LATS21.15076399
44TYK21.14410768
45MAPKAPK51.13812515
46MAP2K61.13418399
47NME21.11012009
48MOS1.08973017
49CDK121.05664819
50MAP3K121.05610258
51FGFR31.04917431
52ERBB31.04620387
53MAPKAPK21.01210249
54STK240.96799884
55MAP3K70.96421341
56PRPF4B0.95421718
57MAP3K100.93220763
58TGFBR20.91036674
59IRAK30.89350744
60BMX0.82788171
61BRAF0.80817468
62PRKCI0.78551767
63ERBB20.78471808
64DYRK1B0.78429674
65RAF10.76145426
66CDK60.75586317
67MAP3K90.73276101
68MAP2K30.70224227
69TESK10.69296511
70ILK0.68278623
71RPS6KA10.68164848
72MAP3K60.67574775
73PRKD10.61482533
74PDGFRB0.60336913
75STK380.58554692
76BCR0.57011299
77RPS6KA20.54677851
78JAK30.53833999
79MAP3K80.53035075
80DDR20.52497431
81MAP2K10.52142494
82PAK20.50985481
83RET0.49875000
84STK100.49589775
85TBK10.47953410
86PIM20.46599923
87PBK0.46372008
88CDC42BPA0.46341995
89CSF1R0.45318863
90SIK30.44470799
91OBSCN0.44221141
92KSR10.43770278
93PDGFRA0.42932835
94GSK3A0.42099341
95IKBKE0.42050967
96MAP3K140.41919449
97NTRK20.41801459
98MAP2K20.41670464
99NLK0.40665905
100NEK60.39668340
101STK30.38849505
102CHUK0.37578730
103STK38L0.36234930
104RPS6KA60.35515364
105KSR20.34728999
106RPS6KB10.34003289
107FGR0.33192112
108PRKD20.32902369
109MAPK120.32751924
110HIPK20.32682916
111MAP2K40.32313361
112RPS6KC10.30730317
113RPS6KL10.30730317
114JAK20.30031891
115ABL20.27071688
116JAK10.27014034
117TSSK60.25709036
118ADRBK10.25644490
119PAK40.25388139
120MTOR0.23541744
121TAOK20.23106160
122ROCK20.22203975
123ALK0.22114407
124MAPK110.21975506
125SGK30.21646569
126ROCK10.21103662
127ERBB40.20743761
128SRC0.20670374
129EIF2AK20.20504019
130BLK0.19780153
131IGF1R0.19647260
132IKBKB0.19559756
133IRAK10.19384088
134GRK70.18922428
135PRKCD0.18880500

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.84694791
2ECM-receptor interaction_Homo sapiens_hsa045123.43440337
3Hedgehog signaling pathway_Homo sapiens_hsa043403.26625213
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.63949121
5Amoebiasis_Homo sapiens_hsa051462.42008814
6Hippo signaling pathway_Homo sapiens_hsa043902.16645808
7Steroid biosynthesis_Homo sapiens_hsa001002.11084937
8Toxoplasmosis_Homo sapiens_hsa051452.08650039
9Small cell lung cancer_Homo sapiens_hsa052222.05584302
10Proteoglycans in cancer_Homo sapiens_hsa052051.98463734
11Focal adhesion_Homo sapiens_hsa045101.81903140
12Linoleic acid metabolism_Homo sapiens_hsa005911.76191198
13Adherens junction_Homo sapiens_hsa045201.75766777
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70870098
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69145736
16Bladder cancer_Homo sapiens_hsa052191.67478329
17Melanogenesis_Homo sapiens_hsa049161.65826474
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64183741
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.61576188
20VEGF signaling pathway_Homo sapiens_hsa043701.53832511
21Axon guidance_Homo sapiens_hsa043601.52012113
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47069007
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45331843
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.40329956
25Acute myeloid leukemia_Homo sapiens_hsa052211.38960123
26Protein digestion and absorption_Homo sapiens_hsa049741.37409137
27Notch signaling pathway_Homo sapiens_hsa043301.37249218
28Tight junction_Homo sapiens_hsa045301.34367734
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31345017
30Wnt signaling pathway_Homo sapiens_hsa043101.28872053
31Prion diseases_Homo sapiens_hsa050201.25596140
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22570269
33Pathways in cancer_Homo sapiens_hsa052001.17587528
34Thyroid cancer_Homo sapiens_hsa052161.15413463
35GnRH signaling pathway_Homo sapiens_hsa049121.13326410
36Arachidonic acid metabolism_Homo sapiens_hsa005901.12977625
37p53 signaling pathway_Homo sapiens_hsa041151.12788470
38Phenylalanine metabolism_Homo sapiens_hsa003601.12757544
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09577995
40MicroRNAs in cancer_Homo sapiens_hsa052061.07435233
41TGF-beta signaling pathway_Homo sapiens_hsa043501.07137377
42Inositol phosphate metabolism_Homo sapiens_hsa005621.04292440
43Insulin signaling pathway_Homo sapiens_hsa049101.02441691
44Staphylococcus aureus infection_Homo sapiens_hsa051501.01222152
45Dilated cardiomyopathy_Homo sapiens_hsa054140.99818885
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.98448021
47Endometrial cancer_Homo sapiens_hsa052130.98087758
48TNF signaling pathway_Homo sapiens_hsa046680.97124085
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94063199
50Sulfur metabolism_Homo sapiens_hsa009200.92648701
51Insulin resistance_Homo sapiens_hsa049310.92049593
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91487863
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87536514
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85122573
55Estrogen signaling pathway_Homo sapiens_hsa049150.84712622
56HTLV-I infection_Homo sapiens_hsa051660.84578650
57Renal cell carcinoma_Homo sapiens_hsa052110.84510967
58Galactose metabolism_Homo sapiens_hsa000520.83691356
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83673274
60Histidine metabolism_Homo sapiens_hsa003400.83046242
61Hepatitis C_Homo sapiens_hsa051600.83042016
62Dorso-ventral axis formation_Homo sapiens_hsa043200.82364985
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81848610
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81798617
65Rap1 signaling pathway_Homo sapiens_hsa040150.80489138
66Caffeine metabolism_Homo sapiens_hsa002320.79860411
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78477460
68Pertussis_Homo sapiens_hsa051330.77991133
69Fatty acid elongation_Homo sapiens_hsa000620.77689963
70Chronic myeloid leukemia_Homo sapiens_hsa052200.77511956
71Apoptosis_Homo sapiens_hsa042100.75411993
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.75040883
73Osteoclast differentiation_Homo sapiens_hsa043800.73175812
74Ribosome_Homo sapiens_hsa030100.72296840
75Ether lipid metabolism_Homo sapiens_hsa005650.71939782
76Ras signaling pathway_Homo sapiens_hsa040140.71508666
77ErbB signaling pathway_Homo sapiens_hsa040120.70915967
78Prolactin signaling pathway_Homo sapiens_hsa049170.69383388
79Pancreatic cancer_Homo sapiens_hsa052120.68836072
80Glioma_Homo sapiens_hsa052140.67710695
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67465532
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.66963689
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.66904132
84Fat digestion and absorption_Homo sapiens_hsa049750.66768102
85Platelet activation_Homo sapiens_hsa046110.65419138
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.64607834
87Non-small cell lung cancer_Homo sapiens_hsa052230.64331324
88Shigellosis_Homo sapiens_hsa051310.61689269
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60502977
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60043719
91MAPK signaling pathway_Homo sapiens_hsa040100.58872049
92Fructose and mannose metabolism_Homo sapiens_hsa000510.57715699
93Prostate cancer_Homo sapiens_hsa052150.56705898
94Salmonella infection_Homo sapiens_hsa051320.56547884
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.56214718
96Leishmaniasis_Homo sapiens_hsa051400.56097496
97Pancreatic secretion_Homo sapiens_hsa049720.55072672
98Gastric acid secretion_Homo sapiens_hsa049710.54849586
99Arginine biosynthesis_Homo sapiens_hsa002200.54614121
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52975076
101Malaria_Homo sapiens_hsa051440.52972605
102Renin secretion_Homo sapiens_hsa049240.52963182
103Influenza A_Homo sapiens_hsa051640.51807862
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51606930
105Sphingolipid metabolism_Homo sapiens_hsa006000.50192780
106Melanoma_Homo sapiens_hsa052180.50108695
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50051660
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48572888
109Long-term depression_Homo sapiens_hsa047300.47953822
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47855419
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47674719
112Glucagon signaling pathway_Homo sapiens_hsa049220.46641086
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45776595
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.45714929
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45279963
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45257789
117Pentose phosphate pathway_Homo sapiens_hsa000300.45184202
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44550565
119Oxytocin signaling pathway_Homo sapiens_hsa049210.44173525
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44006798
121Endocytosis_Homo sapiens_hsa041440.43141353
122Glycerolipid metabolism_Homo sapiens_hsa005610.40477705
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.40361887
124Choline metabolism in cancer_Homo sapiens_hsa052310.39003818
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.38279131
126Arginine and proline metabolism_Homo sapiens_hsa003300.32587597
127Viral carcinogenesis_Homo sapiens_hsa052030.31856249
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31582461

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